anisomycin and pyrrolidine

anisomycin has been researched along with pyrrolidine* in 1 studies

Other Studies

1 other study(ies) available for anisomycin and pyrrolidine

ArticleYear
Alpha-rhamnosidase inhibitory activities of polyhydroxylated pyrrolidine.
    Bioorganic & medicinal chemistry letters, 2005, Oct-01, Volume: 15, Issue:19

    We designed and synthesized polyhydroxylated pyrrolidines 1-12 from L-tyrosine, L-phenylalanine, and D-tyrosine through iodine-mediated intramolecular cyclization followed by Woodward-Prevost reaction. The synthetic polyhydroxylated pyrrolidines were identified with structure-based inhibitory activity and selective inhibitory activity against alpha-rhamnosidase. (2S,3S,4R)-deacetyl anisomycin 7 was the best inhibitor among the 12 polyhydroxylated pyrrolidines because it possesses the same stereoconfiguration at C1, C2, C3 as alpha-L-rhamnopyranoside. An investigation into the nature of the inhibition showed that the synthetic pyrrolidines are competitive inhibitors. They also did not have remarkable inhibitory activity against seven glycosidases (alpha-glucosidase, alpha-mannosidase, alpha-amylase, beta-glucosidase, beta-galactosidase, beta-amylase, and invertase).

    Topics: Amino Acids; Anisomycin; Binding, Competitive; Cyclization; Glycoside Hydrolases; Hydroxylation; Inhibitory Concentration 50; Pyrrolidines; Structure-Activity Relationship

2005