aniline mustard has been researched along with hydroxyaniline mustard in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hansch, C; Leo, A; Panthananickal, A | 2 |
| Arnold, LA; Balakrishnan, K; Chen, W; Fan, H; Fan, Y; Gandhi, V; Peng, X; Sun, H; Wang, Y | 1 |
| Double, JA; Wilman, DE; Workman, P | 1 |
| Chern, JW; Roffler, SR; Tung, E; Wang, SM; Yeh, MY | 1 |
| Ball, CR; Double, JA | 1 |
| Deliconstantinos, G; Ramantanis, G; Todorou, DK | 1 |
| Bauguess, CT; Beamer, RL; Wise, JW; Wynn, JE | 1 |
| Blakey, DC; Burke, PJ; Davies, DH; Dowell, RI; East, SJ; Mauger, AB; Melton, RG; Sharma, SK; Springer, CJ | 1 |
| Blackburn, GM; Blakey, D; Boyle, T; Datta, A; Partridge, LJ; Wentworth, P | 1 |
| Chen, BM; Cheng, TL; Chern, JW; Liu, PW; Roffler, SR; Wei, SL; Wu, MF | 1 |
| Chen, BM; Cheng, TL; Chern, JW; Chou, WC; Roffler, SR | 1 |
| Chen, BM; Cheng, CM; Cheng, TL; Liao, KW; Roffler, SR; Tzou, SC | 1 |
| Begent, RH; Bell, J; Boxer, GM; Chester, KA; Cruickshank, C; Francis, RJ; Green, AJ; Hartley, JA; Martin, J; Mayer, A; Sharma, SK; Springer, CJ; Tolner, B; Wren, J | 1 |
1 trial(s) available for aniline mustard and hydroxyaniline mustard
| Article | Year |
|---|---|
A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug.
Topics: Aged; Aniline Mustard; Antibodies, Monoclonal; Antineoplastic Agents; Carcinoembryonic Antigen; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; gamma-Glutamyl Hydrolase; History, 16th Century; History, 17th Century; Humans; Imaging, Three-Dimensional; Immunoconjugates; Male; Prodrugs; Recombinant Fusion Proteins | 2006 |
13 other study(ies) available for aniline mustard and hydroxyaniline mustard
| Article | Year |
|---|---|
Structure-activity relationship of aniline mustards acting against B-16 melanoma in mice.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Melanoma; Mice; Neoplasms, Experimental; Nitrogen Mustard Compounds; Structure-Activity Relationship | 1979 |
Structure-activity relationships in antitumor aniline mustards.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Hydrolysis; Lethal Dose 50; Leukemia L1210; Leukemia, Experimental; Mice; Models, Biological; Nitrogen Mustard Compounds; Rats; Structure-Activity Relationship | 1978 |
Discovery and Optimization of Novel Hydrogen Peroxide Activated Aromatic Nitrogen Mustard Derivatives as Highly Potent Anticancer Agents.
Topics: Antineoplastic Agents, Alkylating; Boronic Acids; Cell Line, Tumor; Drug Design; Esters; Humans; Hydrogen Peroxide; Nitrogen Mustard Compounds | 2018 |
Enzyme activated anti-tumour agents--III. Hydrolysis of conjugates of p-hydroxyaniline mustard in aqueous solution.
Topics: Alkylating Agents; Aniline Mustard; Chemical Phenomena; Chemistry; Half-Life; Hydrolysis; Kinetics; Nitrogen Mustard Compounds | 1976 |
Anti-neoplastic glucuronide prodrug treatment of human tumor cells targeted with a monoclonal antibody-enzyme conjugate.
Topics: Aniline Mustard; Antibodies, Monoclonal; Antineoplastic Agents; Enzyme Activation; Glucuronidase; Humans; Prodrugs; Tumor Cells, Cultured | 1991 |
Enzyme activated anti-tumour agents. Conjugates of p-hydroxyaniline mustard as substrates for hydrolytic enzymes.
Topics: Aniline Compounds; Aniline Mustard; Animals; Antineoplastic Agents; Cattle; Glucuronates; Glucuronidase; Hydrolases; Intestinal Mucosa; Kinetics; Liver; Lysosomes; Microsomes, Liver; Mollusca; Nitrogen Mustard Compounds; Phosphates; Phosphoric Monoester Hydrolases; Rats; Sulfatases; Sulfates; Triticum | 1974 |
Cytotoxicity of aniline mustard glucuronide alone or in a combination with glucose in Walker cells in culture and sarcoma-180 tumour bearing animals.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cells, Cultured; Drug Evaluation, Preclinical; Drug Therapy, Combination; Glucose; Nitrogen Mustard Compounds; Rats; Sarcoma 180 | 1983 |
Synthesis and bioevaluation of a series of alkyl ethers of p-N,N-bis(2-chloroethyl)aminophenol.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Lethal Dose 50; Leukemia L1210; Mice; Mice, Inbred DBA; Mice, Inbred ICR; Nitrogen Mustard Compounds | 1982 |
Anti-tumour effects of an antibody-carboxypeptidase G2 conjugate in combination with phenol mustard prodrugs.
Topics: Aniline Mustard; Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antineoplastic Agents, Alkylating; Bacterial Proteins; Biotransformation; Carcinoembryonic Antigen; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Female; gamma-Glutamyl Hydrolase; Humans; Immunoconjugates; Immunoglobulin Fab Fragments; Mice; Mice, Nude; Neoplasm Transplantation; Prodrugs; Pseudomonas; Substrate Specificity; Tumor Cells, Cultured | 1995 |
Toward antibody-directed "abzyme" prodrug therapy, ADAPT: carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing.
Topics: Aniline Mustard; Antibodies, Catalytic; Antibody Affinity; Antineoplastic Agents, Alkylating; Carcinoma; Colonic Neoplasms; Haptens; Humans; Hydrolysis; Nitrogen Mustard Compounds; Prodrugs; Tumor Cells, Cultured | 1996 |
Bystander killing of tumour cells by antibody-targeted enzymatic activation of a glucuronide prodrug.
Topics: Aniline Mustard; Animals; Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Diffusion; Drug Screening Assays, Antitumor; Glucuronidase; Immunohistochemistry; Immunotoxins; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Polyethylene Glycols; Prodrugs; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Cells, Cultured | 1999 |
Characterization of an antineoplastic glucuronide prodrug.
Topics: Aniline Mustard; Animals; Antibodies; Antineoplastic Agents, Alkylating; Glucuronates; Glucuronidase; Humans; Prodrugs; Rats; Transfection; Tumor Cells, Cultured | 1999 |
Hapten-directed targeting to single-chain antibody receptors.
Topics: Aniline Mustard; Animals; Antibodies, Monoclonal; Cell Line, Tumor; Drug Delivery Systems; Gene Expression; Haptens; Immunotherapy; Injections, Intravenous; Melanoma; Mice; Neoplasms, Experimental; Oxazoles; Polyethylene Glycols; Prodrugs; Receptors, Cell Surface; Recombinant Proteins | 2004 |