anhydrovitamin-a and vanillin

anhydrovitamin-a has been researched along with vanillin* in 1 studies

Other Studies

1 other study(ies) available for anhydrovitamin-a and vanillin

Article	Year
A helical lid converts a sulfotransferase to a dehydratase. Nature structural biology, 2001, Volume: 8, Issue:5 We report here the crystal structure of retinol dehydratase, an enzyme that catalyzes the synthesis of anhydroretinol. The enzyme is a member of the sulfotransferase superfamily and its crystal structure reveals the insertion of a helical lid into a canonical sulfotransferase fold. Site-directed mutations demonstrate that this inserted lid is necessary for anhydroretinol production but not for sulfonation; thus, insertion of a helical lid can convert a sulfotransferase into a dehydratase. Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Benzaldehydes; Binding Sites; Crystallography, X-Ray; Hydro-Lyases; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Secondary; Sequence Alignment; Structure-Activity Relationship; Sulfates; Sulfotransferases; Vitamin A	2001

Article

Year

A helical lid converts a sulfotransferase to a dehydratase.

Nature structural biology, 2001, Volume: 8, Issue:5

We report here the crystal structure of retinol dehydratase, an enzyme that catalyzes the synthesis of anhydroretinol. The enzyme is a member of the sulfotransferase superfamily and its crystal structure reveals the insertion of a helical lid into a canonical sulfotransferase fold. Site-directed mutations demonstrate that this inserted lid is necessary for anhydroretinol production but not for sulfonation; thus, insertion of a helical lid can convert a sulfotransferase into a dehydratase.

Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Benzaldehydes; Binding Sites; Crystallography, X-Ray; Hydro-Lyases; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Secondary; Sequence Alignment; Structure-Activity Relationship; Sulfates; Sulfotransferases; Vitamin A

2001