angiotensin-iii has been researched along with icatibant* in 1 studies
1 other study(ies) available for angiotensin-iii and icatibant
| Article | Year |
|---|---|
The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors.
The N-terminal sequence of icatibant, a widely used peptide antagonist of the bradykinin B(2) receptors, is analogous to that of other known aminopeptidase N inhibitors. Icatibant competitively inhibited the hydrolysis of L-Ala-p-nitroanilide by recombinant aminopeptidase N (K(i) 9.1 microM). In the rabbit aorta, icatibant (10-30 microM) potentiated angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT(1) receptors), and Lys-des-Arg(9)-bradykinin, but not des-Arg(9)-bradykinin (effects mediated by the bradykinin B(1) receptors), consistent with the known susceptibility of these agonists to aminopeptidase N. At concentrations possibly reached in vivo (e.g., in kidneys), icatibant alters physiological systems different from bradykinin B(2) receptors. Topics: Angiotensin II; Angiotensin III; Aniline Compounds; Animals; Aorta; Bradykinin; Bradykinin B2 Receptor Antagonists; CD13 Antigens; Dose-Response Relationship, Drug; In Vitro Techniques; Kallidin; Kinetics; Protease Inhibitors; Quinolines; Rabbits; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Angiotensin; Recombinant Proteins; Signal Transduction; Vasoconstriction; Vasoconstrictor Agents | 2006 |