Compounds > angiotensin ii
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angiotensin ii and simvastatin

angiotensin ii has been researched along with simvastatin in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (8.89)18.2507
2000's25 (55.56)29.6817
2010's12 (26.67)24.3611
2020's4 (8.89)2.80

Authors

AuthorsStudies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Altieri, PI; Castro, M; Escobales, N; Sanabria, P1
Haneda, T; Kashiwagi, Y; Kawabe, J; Kikuchi, K; Nakamura, Y; Oi, S; Osaki, J1
Chen, X; Guan, JX; Luo, JD; Zhang, GP; Zhang, WW1
Ichihara, K; Inagami, T; Landon, EJ; Satoh, K; Tang, H1
Grimm, M; Kitakaze, M; Liao, JK; Liao, Y; Nakagami, H; Node, K; Takemoto, M; Takemoto, Y1
Cristol, JP; Delbosc, S; Jover, B; Mimran, A1
El-Ani, D; Zimlichman, R1
Böhm, M; Kilter, H; Konkol, C; Laufs, U; Nickenig, G; Wassmann, S1
Altieri, PI; Crespo, MJ; Escobales, N; Furilla, RA1
Cristol, JP; Delbosc, S; Descomps, B; Jover, B; Mimran, A1
Arakawa, K; Kugi, M; Matsunaga, A; Ono, J; Sasaki, J1
Fujimura, A; Sugimoto, K1
Li, Q; Liu, L; Xiao, J; Xu, Z; Zhao, S1
Chew, TL; Chisholm, R; Danesh, FR; Kanwar, YS; Sadeghi, MM; Xu, H; Zeng, L1
Daniel, WG; Eskafi, S; Gabler, C; Garlichs, CD; Illmer, T; Lorenz, HM; Roerick, O; Schmeisser, A; Soehnlein, O; Strasser, R1
Wang, YX1
Bayorh, MA; Eatman, D; Feuerstein, GZ; Ganafa, AA; Walton, M1
Banes-Berceli, AK; Brands, M; Caldwell, RW; Eaton, DC; Fulton, D; Ma, G; Marrero, MB; Shaw, S; Stern, DM1
Chen, WP; Chiang, FT; Hsieh, CS; Hsu, KL; Hwang, JJ; Lai, LP; Lin, JL; Tsai, CT; Tseng, CD; Tseng, YZ; Wang, DL1
Bayorh, MA; Eatman, D; Feuerstein, GZ; Layas, MF; Mann, G1
Delbosc, S; Jover, B; Mimran, A; Rugale, C1
Chiang, FT; Hsieh, CS; Hsu, KL; Hwang, JJ; Kuo, KT; Lai, LP; Lin, JL; Tsai, CT; Tseng, CD; Tseng, YZ1
Choi, HG; Choi, MK; Kim, AR; Kim, JA; Ko, YJ; Kwak, MK; Lee, JS; Park, SY; Yong, CS1
Li, M; Li, Z; Sun, X1
Carvajal-González, G; Egido, J; Mezzano, S; Ortiz, A; Rodrigues Díez, R; Rodrigues-Díez, R; Rodríguez-Vita, J; Ruiz-Ortega, M; Sánchez-López, E; Selgas, R1
Aoyama, I; Bomsztyk, K; Komers, R; Koopmeiners, JS; Naito, M; Schnaper, HW; Shenoy, A1
Huang, Y; Li, J; Lü, XW; Xu, J; Zhu, PL1
Guo, WG; Li, RY; Liu, XT; Lu, ZF; Shi, XQ; Shu, Q; Su, FF; Yang, GD; Yuan, LJ; Zheng, QS1
Beasley, D; Galper, JB; Moulton, KS; Naggar, JC; Park, HJ; Welzig, CM; Zhang, Y1
Sikora, M; Szczepanska-Sadowska, E; Ufnal, M; Zera, T1
Cullen, B; Golledge, J; Moran, C; Rush, C1
Civantos, E; Egido, J; Lavoz, C; Mezzano, S; Ortiz, A; Rayego-Mateos, S; Rodrigues Díez, R; Rodrigues-Díez, R; Rodríguez-Vita, J; Ruiz-Ortega, M1
Fukuda, N; Jumabay, M; Matsumoto, K; Matsumoto, T; Saito, K; Shimosawa, T; Soma, M; Ueno, T; Yamamoto, C1
Caldwell, RB; Caldwell, RW; Chandra, S; Iddings, JA; Romero, MJ; Shatanawi, A; Umapathy, NS; Verin, AD1
Liu, DH; Tang, YB; Wang, M; Xue, SJ; Zhang, Z1
Dong, L; Qu, X; Shen, F; Zhang, X; Zhao, X1
Chen, J; Guan, N; Huo, X; Sun, D; Xi, H; Zhang, F1
Aleksandrowicz, M; Drapala, A; Kozniewska, E; Sikora, M; Skrzypecki, J; Ufnal, M; Zera, T1
Carvalho, V; Castro-Faria-Neto, HC; Estato, V; Freitas, F; Lessa, MA; Reis, P; Tibirica, E; Torres, R1
Ding, G; Ma, Y; Yang, J; Yang, Q; Yang, Y1
Grochot-Przęczek, A; Hajduk, K; Józkowicz, A; Klóska, D; Kopacz, A; Neumayer, C; Piechota-Polanczyk, A; Werner, E1
Bae, E; Han, SW; Kim, JE; Kim, YS; Lee, S; Moon, JJ; Park, DJ; Yang, SH; Yu, MY1
Ge, X; Lu, Y; Meng, L; Meng, X; Sui, W; Wang, X; Zhang, Y; Zhong, M1
Cysewski, D; Grochot-Przęczek, A; Józkowicz, A; Klóska, D; Kopacz, A; Kraszewska, I; Lenartowicz, M; Nowak, W; Piechota-Polańczyk, A; Przepiórska, K; Łoboda, A1

Reviews

1 review(s) available for angiotensin ii and simvastatin

ArticleYear
Cardiovascular functional phenotypes and pharmacological responses in apolipoprotein E deficient mice.
    Neurobiology of aging, 2005, Volume: 26, Issue:3

    Topics: Angiotensin II; Animals; Aortic Diseases; Apolipoproteins E; Arteriosclerosis; Cardiac Output, High; Cardiomegaly; Cardiovascular System; Enzyme Inhibitors; Estradiol; Hypercholesterolemia; Hyperglycemia; Mice; Mice, Knockout; NG-Nitroarginine Methyl Ester; Phenotype; Simvastatin

2005

Trials

2 trial(s) available for angiotensin ii and simvastatin

ArticleYear
Different effects of simvastatin and pravastatin on adrenal sensitivity to angiotensin II.
    British journal of clinical pharmacology, 2003, Volume: 56, Issue:6

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Cross-Over Studies; Diuretics; Female; Furosemide; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Pravastatin; Simvastatin

2003
Simvastatin reduces interleukin-1beta secretion by peripheral blood mononuclear cells in patients with essential hypertension.
    Clinica chimica acta; international journal of clinical chemistry, 2004, Volume: 344, Issue:1-2

    Topics: Aged; Angiotensin II; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Hypertension; Inflammation; Interleukin-1; Leukocytes, Mononuclear; Lipids; Male; Middle Aged; Simvastatin; Tetrazoles; Valine; Valsartan

2004

Other Studies

42 other study(ies) available for angiotensin ii and simvastatin

ArticleYear
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
Simvastatin releases Ca2+ from a thapsigargin-sensitive pool and inhibits InsP3-dependent Ca2+ mobilization in vascular smooth muscle cells.
    Journal of cardiovascular pharmacology, 1996, Volume: 27, Issue:3

    Topics: Angiotensin II; Animals; Calcium; Calcium-Transporting ATPases; Cells, Cultured; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inositol 1,4,5-Trisphosphate; Lovastatin; Muscle, Smooth, Vascular; Rats; Simvastatin; Thapsigargin

1996
Lovastatin prevents angiotensin II-induced cardiac hypertrophy in cultured neonatal rat heart cells.
    European journal of pharmacology, 1999, Jul-02, Volume: 376, Issue:1-2

    Topics: Angiotensin II; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cell Division; Cell Membrane; Cells, Cultured; DNA; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Myocardium; Naphthalenes; Pravastatin; Proto-Oncogene Proteins p21(ras); Rats; Rats, Sprague-Dawley; RNA; Simvastatin

1999
Simvastatin inhibits cardiac hypertrophy and angiotensin-converting enzyme activity in rats with aortic stenosis.
    Clinical and experimental pharmacology & physiology, 1999, Volume: 26, Issue:11

    Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Abdominal; Blood Pressure; Captopril; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxyproline; Hypertrophy, Left Ventricular; Organ Size; Peptidyl-Dipeptidase A; Rats; Simvastatin; Time Factors

1999
3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors block calcium-dependent tyrosine kinase Pyk2 activation by angiotensin II in vascular endothelial cells. involvement of geranylgeranylation of small G protein Rap1.
    The Journal of biological chemistry, 2001, May-11, Volume: 276, Issue:19

    Topics: Angiotensin II; Animals; Calcimycin; Calcium; Calmodulin; Cell Membrane; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Focal Adhesion Kinase 2; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Prenylation; Protein-Tyrosine Kinases; Pulmonary Veins; rap1 GTP-Binding Proteins; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Simvastatin; Tetradecanoylphorbol Acetate

2001
Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy.
    The Journal of clinical investigation, 2001, Volume: 108, Issue:10

    Topics: Angiotensin II; Animals; Antioxidants; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Heart; Mice; Myocardium; Oxidation-Reduction; Promoter Regions, Genetic; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Simvastatin; Superoxides

2001
[Simvastatin attenuates cardiovascular effects and oxidative stress induced by angiotensin II].
    Archives des maladies du coeur et des vaisseaux, 2001, Volume: 94, Issue:11

    Topics: Angiotensin II; Animals; Anticholesteremic Agents; Blood Pressure; Cardiomegaly; Hypertension; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin

2001
Simvastatin induces apoptosis of cultured rat cardiomyocytes.
    Journal of basic and clinical physiology and pharmacology, 2001, Volume: 12, Issue:4

    Topics: Angiotensin II; Animals; Anticholesteremic Agents; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Coloring Agents; Creatine Kinase; DNA; DNA Fragmentation; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Fructose-Bisphosphate Aldolase; L-Lactate Dehydrogenase; Microscopy, Fluorescence; Myocardium; Rats; Simvastatin

2001
Impact of HMG CoA reductase inhibition on small GTPases in the heart.
    Cardiovascular research, 2002, Volume: 53, Issue:4

    Topics: Angiotensin II; Animals; Atorvastatin; Atrial Natriuretic Factor; Cardiac Myosins; Cardiomegaly; Cell Membrane; Cells, Cultured; Gene Expression Regulation; GTP Phosphohydrolases; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Myocardium; Myosin Light Chains; Pyrroles; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; RNA, Messenger; Simvastatin

2002
Inhibition of smooth muscle cell calcium mobilization and aortic ring contraction by lactone vastatins.
    Journal of hypertension, 1996, Volume: 14, Issue:1

    Topics: Angiogenesis Inhibitors; Angiotensin II; Animals; Aorta, Thoracic; Calcium; Collagen Type VIII; Dose-Response Relationship, Drug; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Lovastatin; Male; Models, Cardiovascular; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin; Vasoconstrictor Agents

1996
Simvastatin prevents angiotensin II-induced cardiac alteration and oxidative stress.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:2

    Topics: Angiotensin II; Animals; Aorta, Thoracic; Body Weight; Creatinine; Dose-Response Relationship, Drug; Eating; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Myocardium; Neutrophils; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Simvastatin; Sodium

2002
Antioxidative effects of fluvastatin on superoxide anion activated by angiotensin II in human aortic smooth muscle cells.
    Cardiovascular drugs and therapy, 2002, Volume: 16, Issue:3

    Topics: Adult; Angiotensin II; Antioxidants; Aorta; Cells, Cultured; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Indoles; Male; Muscle, Smooth, Vascular; Simvastatin; Superoxides

2002
Simvastatin modulates angiotensin II signaling pathway by preventing Rac1-mediated upregulation of p27.
    Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:7

    Topics: Active Transport, Cell Nucleus; Angiotensin II; Animals; Blotting, Western; Cell Cycle Proteins; Cell Line; Cyclin-Dependent Kinase Inhibitor p27; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leucine; Microscopy, Confocal; Models, Biological; Oxidation-Reduction; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Rats; Signal Transduction; Simvastatin; Transfection; Tumor Suppressor Proteins; Up-Regulation

2004
ACE inhibition lowers angiotensin II-induced chemokine expression by reduction of NF-kappaB activity and AT1 receptor expression.
    Biochemical and biophysical research communications, 2004, Dec-10, Volume: 325, Issue:2

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Cell Line; Chemokine CCL2; Chemokines; Down-Regulation; Drug Interactions; Endothelium, Vascular; Humans; Imidazoles; Interleukin-8; Losartan; Monocytes; NF-kappa B; Peptidyl-Dipeptidase A; Pyridines; Ramipril; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Simvastatin; Umbilical Veins

2004
Simvastatin and losartan enhance nitric oxide and reduce oxidative stress in salt-induced hypertension.
    American journal of hypertension, 2005, Volume: 18, Issue:11

    Topics: Acetylcholine; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Body Weight; Drug Therapy, Combination; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; In Vitro Techniques; Kidney; Losartan; Male; Mesenteric Arteries; Myocardium; Nitric Oxide; Organ Size; Oxidative Stress; Prostaglandins; Rats; Rats, Inbred Dahl; Simvastatin; Sodium Chloride, Dietary; Superoxides; Thromboxane A2; Treatment Outcome; Vasoconstriction; Vasodilator Agents

2005
Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells.
    American journal of physiology. Renal physiology, 2006, Volume: 291, Issue:1

    Topics: Angiotensin II; Animals; Anticholesteremic Agents; Blood Glucose; Cells, Cultured; Collagen Type IV; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Janus Kinase 2; Male; Mesangial Cells; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Signal Transduction; Simvastatin; STAT1 Transcription Factor; STAT3 Transcription Factor; Terpenes

2006
Angiotensin II increases expression of alpha1C subunit of L-type calcium channel through a reactive oxygen species and cAMP response element-binding protein-dependent pathway in HL-1 myocytes.
    Circulation research, 2007, May-25, Volume: 100, Issue:10

    Topics: Angiotensin II; Animals; Calcium; Calcium Channels, L-Type; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; DNA; Losartan; Myocytes, Cardiac; NADPH Oxidases; Protein Kinase C; Rats; Rats, Wistar; Reactive Oxygen Species; Response Elements; Simvastatin; Superoxides; Transcription, Genetic

2007
The effect of diet on simvastatin and losartan enhancement of endothelial function.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2007, Volume: 29, Issue:5

    Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Diet; Diet, Sodium-Restricted; Dietary Fats; Endothelium, Vascular; Epoprostenol; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Kidney; Lipids; Losartan; Male; Nitric Oxide; Rats; Rats, Inbred SHR; Simvastatin; Sodium, Dietary; Superoxides; Thromboxane A2

2007
Simvastatin reverses target organ damage and oxidative stress in Angiotensin II hypertension: comparison with apocynin, tempol, and hydralazine.
    Journal of cardiovascular pharmacology, 2007, Volume: 50, Issue:3

    Topics: Acetophenones; Albuminuria; Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Cardiomegaly; Carotid Arteries; Cyclic N-Oxides; Hydralazine; Hypertension; Hypolipidemic Agents; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin; Spin Labels; Superoxides; Tunica Media

2007
Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling.
    Circulation, 2008, Jan-22, Volume: 117, Issue:3

    Topics: Angiotensin II; Animals; Atrial Fibrillation; Cells, Cultured; Fibroblasts; Heart Atria; Humans; Losartan; Muscle Cells; Phosphorylation; rac1 GTP-Binding Protein; Rats; Rats, Wistar; Signal Transduction; Simvastatin; STAT3 Transcription Factor; Ventricular Remodeling

2008
Inhibitory effect of simvastatin on the TNF-alpha- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation.
    Archives of pharmacal research, 2008, Volume: 31, Issue:2

    Topics: Angiotensin II; Cell Adhesion; Cell Line; Endothelial Cells; Enzyme Activation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Monocytes; NADPH Oxidases; Polyisoprenyl Phosphates; Protein Prenylation; Reactive Oxygen Species; Simvastatin; Tumor Necrosis Factor-alpha; Umbilical Veins

2008
Statins suppress MMP2 secretion via inactivation of RhoA/ROCK pathway in pulmonary vascular smooth muscles cells.
    European journal of pharmacology, 2008, Sep-04, Volume: 591, Issue:1-3

    Topics: Angiotensin II; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Matrix Metalloproteinase 2; Muscle, Smooth, Vascular; Pulmonary Artery; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin

2008
Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways.
    Pharmaceutical research, 2008, Volume: 25, Issue:10

    Topics: Angiotensin II; Atorvastatin; Cell Line; Cell Transdifferentiation; Connective Tissue Growth Factor; Epithelial Cells; Fibrosis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinase Kinases; Phenotype; Protein Kinase Inhibitors; Pyrroles; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Time Factors; Transfection

2008
High ambient glucose augments angiotensin II-induced proinflammatory gene mRNA expression in human mesangial cells: effects of valsartan and simvastatin.
    American journal of nephrology, 2009, Volume: 30, Issue:2

    Topics: Angiotensin II; Gene Expression Regulation; Glucose; Hemodynamics; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Inflammation; Kidney; Mesangial Cells; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Tetrazoles; Valine; Valsartan

2009
Synergism of simvastatin with losartan prevents angiotensin II-induced cardiomyocyte apoptosis in vitro.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:4

    Topics: Angiotensin II; Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Cell Culture Techniques; Cell Survival; Drug Synergism; Losartan; Myocytes, Cardiac; Proto-Oncogene Proteins c-bcl-2; Rats; Simvastatin

2009
Simvastatin inhibits angiotensin II-induced cardiac cell hypertrophy: role of Homer 1a.
    Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:1

    Topics: Angiotensin II; Animals; Animals, Newborn; Anticholesteremic Agents; Cardiomegaly; Carrier Proteins; Cell Line; Drug Interactions; Drug Therapy, Combination; Extracellular Signal-Regulated MAP Kinases; Homer Scaffolding Proteins; Myocytes, Cardiac; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Simvastatin; Transfection; Up-Regulation

2010
Simvastatin inhibits angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice: possible role of ERK.
    Arteriosclerosis, thrombosis, and vascular biology, 2009, Volume: 29, Issue:11

    Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Benzamides; Blood Pressure; Blotting, Western; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; MAP Kinase Kinase Kinase 3; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Random Allocation; Reference Values; Renin-Angiotensin System; Simvastatin

2009
Simvastatin reduces pressor response to centrally administered angiotensin II.
    American journal of hypertension, 2010, Volume: 23, Issue:9

    Topics: Angiotensin II; Animals; Blood Pressure; Brain; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Losartan; Male; Rats; Rats, Sprague-Dawley; Simvastatin

2010
Efficacy of simvastatin in reducing aortic dilatation in mouse models of abdominal aortic aneurysm.
    Cardiovascular drugs and therapy, 2010, Volume: 24, Issue:5-6

    Topics: Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Apolipoproteins E; Lipids; Male; Mice; Mice, Transgenic; Plaque, Atherosclerotic; Receptors, Lipoprotein; Simvastatin

2010
Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process.
    PloS one, 2010, Nov-30, Volume: 5, Issue:11

    Topics: Angiotensin II; Animals; Aorta; Atorvastatin; Blotting, Western; Cells, Cultured; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Simvastatin; Smad Proteins; Transforming Growth Factor beta; Vasoconstrictor Agents

2010
Protective effects of statin on cardiac fibrosis and apoptosis in adrenomedullin-knockout mice treated with angiotensin II and high salt loading.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2011, Volume: 34, Issue:3

    Topics: Actins; Adrenomedullin; Angiotensin II; Animals; Antigens, Ly; Apoptosis; Capillaries; Coronary Vessels; Fibrosis; Glycoproteins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Membrane Proteins; Mice; Mice, Knockout; Myocardium; Proto-Oncogene Proteins c-kit; Simvastatin; Sodium Chloride, Dietary; Treatment Outcome

2011
Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway.
    American journal of physiology. Cell physiology, 2011, Volume: 300, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arginase; Boronic Acids; Cattle; Cell Line; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gq-G11; Imidazoles; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; rho-Associated Kinases; RNA, Small Interfering; Signal Transduction; Simvastatin

2011
Simvastatin ameliorates angiotensin II-induced endothelial dysfunction through restoration of Rho-BH4-eNOS-NO pathway.
    Cardiovascular drugs and therapy, 2012, Volume: 26, Issue:1

    Topics: Acetylcholine; Angiotensin II; Animals; Biopterins; Blood Pressure; Carotid Arteries; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; GTP Cyclohydrolase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Renal; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Simvastatin; Vasodilation

2012
Influence and pathophysiological mechanisms of simvastatin on prostatic hyperplasia in spontaneously hypertensive rats.
    Urologia internationalis, 2013, Volume: 91, Issue:4

    Topics: Angiotensin II; Animals; Endoplasmic Reticulum; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Inflammation; Insulin-Like Growth Factor I; Interleukin-6; Male; Mitochondria; Nitric Oxide Synthase Type III; Prostatic Hyperplasia; Rats; Rats, Inbred SHR; Simvastatin

2013
Simvastatin attenuates angiotensin II‑induced inflammation and oxidative stress in human mesangial cells.
    Molecular medicine reports, 2015, Volume: 11, Issue:2

    Topics: Angiotensin II; Anticholesteremic Agents; Cell Line; Chemokine CCL2; Cyclooxygenase 2; Dinoprostone; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Mesangial Cells; NADPH Oxidases; Oxidative Stress; PPAR gamma; Protein Kinase C; Reactive Oxygen Species; RNA, Messenger; Simvastatin; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2015
The effect of simvastatin and pravastatin on arterial blood pressure, baroreflex, vasoconstrictor, and hypertensive effects of angiotensin II in Sprague-Dawley rats.
    Journal of the American Society of Hypertension : JASH, 2014, Volume: 8, Issue:12

    Topics: Angiotensin II; Animals; Baroreflex; Blood Pressure; Drug Synergism; Heart Rate; Hypertension; Male; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin; Vasoconstriction

2014
Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II-induced microcirculatory changes in a model of primary hypertension.
    Microcirculation (New York, N.Y. : 1994), 2017, Volume: 24, Issue:8

    Topics: Angiotensin II; Animals; Cerebrovascular Circulation; Disease Models, Animal; Hypertension; Male; Microcirculation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Simvastatin

2017
Angiotensin II induces cholesterol accumulation and injury in podocytes.
    Scientific reports, 2017, 09-06, Volume: 7, Issue:1

    Topics: Angiotensin II; Animals; Apoptosis; Cholesterol; Cytoskeleton; Disease Models, Animal; Gene Expression; Lipid Metabolism; Perilipin-2; Podocytes; Renal Insufficiency, Chronic; Simvastatin

2017
Simvastatin Attenuates Abdominal Aortic Aneurysm Formation Favoured by Lack of Nrf2 Transcriptional Activity.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Blood Pressure; Collagen; Elastin; Humans; Inflammation; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Signal Transduction; Simvastatin; Transcription, Genetic; Vascular Cell Adhesion Molecule-1

2020
Renoprotective Effect of KLF2 on Glomerular Endothelial Dysfunction in Hypertensive Nephropathy.
    Cells, 2022, 02-22, Volume: 11, Issue:5

    Topics: Angiotensin II; Animals; Atherosclerosis; Endothelial Cells; Fibrosis; Humans; Hypertension, Renal; Interleukin-18; Kruppel-Like Transcription Factors; Mice; Nephritis; RNA, Messenger; Simvastatin; Transcription Factors

2022
Statin therapy protects against abdominal aortic aneurysms by inducing the accumulation of regulatory T cells in ApoE
    Journal of molecular medicine (Berlin, Germany), 2022, Volume: 100, Issue:7

    Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Dysbiosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Knockout; Simvastatin; T-Lymphocytes, Regulatory

2022
Co-administration of angiotensin II and simvastatin triggers kidney injury upon heme oxygenase-1 deficiency.
    Free radical biology & medicine, 2023, Aug-20, Volume: 205

    Topics: Angiotensin II; Animals; Glutathione; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypertension; Iron; Kidney; Mice; Mucin-1; Simvastatin

2023