angiotensin ii has been researched along with candesartan cilexetil in 127 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 83 (65.35) | 18.2507 |
| 2000's | 38 (29.92) | 29.6817 |
| 2010's | 4 (3.15) | 24.3611 |
| 2020's | 2 (1.57) | 2.80 |
| Authors | Studies |
|---|---|
| Makino, J; Okamoto, H; Takano, M; Yayama, K | 1 |
| Kawamura, K; Kubota, J; Mori, T; Nishimura, H; Ueyama, M | 1 |
| Ito, K; Kito, G; Shiomi, M | 2 |
| Higashiura, K; Hirata, A; Iimura, O; Masuda, A; Matsuda, K; Miyazaki, Y; Nakagawa, M; Shimamoto, K; Takizawa, H; Ura, N | 1 |
| Düsing, R; Feltkamp, H; Flesch, M; Ko, Y; Sachinidis, A; Seul, C; Vetter, H | 1 |
| Chatani, F; Hamaguchi, A; Inada, Y; Ishimura, Y; Iwao, H; Kim, S; Miura, K; Ohta, K; Omura, T; Yukimura, T | 1 |
| Kanno, M; Kitabatake, A; Kohya, T; Nakaya, H; Saito, H; Tohse, N; Yokoshiki, H | 1 |
| Inada, Y; Ishimura, Y; Kanagawa, R; Nishikawa, K; Wada, T | 1 |
| Hamaguchi, A; Iwao, H; Kawamura, M; Kim, S; Miura, K; Ohta, K; Omura, T; Wanibuchi, H; Yukimura, T | 1 |
| Higaki, J; Kawaguchi, N; Kobayashi, R; Mikami, H; Nagano, M; Nakamura, F; Ogihara, T; Onishi, S | 1 |
| Biollaz, J; Brunner, HR; Delacrétaz, E; Nussberger, J; Waeber, B | 1 |
| Chatani, F; Hamaguchi, A; Inada, Y; Ishimura, Y; Kim, S; Miura, K; Ohta, K; Omura, T; Wada, T; Yukimura, T | 3 |
| Brunner, HR; Burnier, M; Delacrétaz, E; Nussberger, J; Waeber, B | 1 |
| Higaki, J; Mikami, H; Nagano, M; Ogihara, T | 1 |
| Dohi, K; Iwano, M; Kagoshima, T; Konishi, N; Masuda, J; Nakamura, Y; Sakaguchi, Y; Sutani, T; Tsuchihashi, M; Tsuruta, S | 1 |
| Matsumori, A; Sasayama, S; Tanaka, A; Wang, W | 1 |
| Inada, Y; Nishikawa, K; Noda, M; Ojima, M; Sanada, T; Shibouta, Y; Wada, T | 1 |
| Akioka, K; Kim, S; Omura, T; Takeuchi, K; Tani, T; Teragaki, M; Toda, I; Yamagishi, H; Yanagi, S; Yoshiyama, M | 1 |
| Ebihara, A; Fujimura, A; Sudoh, T | 1 |
| Higaki, J; Mikami, H; Morishita, R; Ogihara, T; Rakugi, H; Yu, H | 1 |
| Kadowaki, T; Kojima, M; Komuro, I; Mizuno, T; Shiojima, I; Tobe, K; Ueki, K; Wang, Y; Yamazaki, T; Zou, Z | 1 |
| Fukuchi, S; Katoh, K; Mizuno, K; Niimura, S | 1 |
| Kim, S; Nishikimi, T; Takeda, T; Takeuchi, K; Yamagishi, H | 1 |
| Inada, Y; Kohara, Y; Kubo, K; Naka, T; Nishikawa, K; Noda, M; Ojima, M; Sanada, T; Shibouta, Y; Wada, T | 1 |
| Imura, Y; Kawamura, M; Nakao, M; Nishikawa, K; Okuda, H; Shino, A; Terashita, Z | 1 |
| Fujioka, Y; Higaki, J; Ikegami, H; Kawaguchi, N; Kobayashi, R; Mikami, H; Nagano, M; Nakamura, F; Ogihara, T; Onishi, S | 1 |
| Higaki, J; Kohara, K; Mikami, H; Ogihara, T; Okuda, N | 1 |
| Akioka, K; Hanatani, A; Iwao, H; Kim, S; Omura, T; Takeda, T; Takeuchi, K; Teragaki, M; Toda, I; Yoshiyama, M | 1 |
| Dzerk, A; Johnson, T; Lee, JW; Miyabayashi, T; Motohashi, M; Naidong, W | 1 |
| Furukawa, Y; Hirozane, T; Matsumori, A; Sasayama, S | 1 |
| Higaki, J; Kohara, K; Mikami, H; Nagano, M; Ogihara, T | 1 |
| Demura, H; Hagiwara, H; Hirose, S; Muraki, T; Naruse, K; Naruse, M; Shionoya, K; Tanabe, A; Tanaka, M; Yoshimoto, T | 1 |
| Düsing, R; el-Haschimi, K; Ko, Y; Sachinidis, A; Seul, C; Vetter, H | 1 |
| Matsumori, A; Sasayama, S | 1 |
| Biollaz, J; Brunner, HR; Buclin, T; Burnier, M; Nussberger, J; Waeber, B | 1 |
| Kito, G; Morimoto, S; Shiomi, M | 1 |
| Kondo, T; Motohashi, M; Tanayama, S; Yoshida, K; Yoshimura, Y | 2 |
| Chatani, F; Sato, K; Sato, S | 1 |
| el-Haschimi, K; Epping, P; Ko, Y; Sachinidis, A; Seul, C; Vetter, H | 1 |
| Chikugo, F; Fukuta, Y; Hori, T; Houchi, H; Katoh, I; Kawahito, T; Kitagawa, T; Oka, M; Yoshizumi, M | 1 |
| Izawa, K; Miyabayashi, T; Motohashi, M; Okuda, T; Yashiki, T | 1 |
| Inada, Y; Kanagawa, R; Nishikawa, K; Ojima, M; Sanada, T; Wada, T | 1 |
| Biollaz, J; Brunner, HR; Buclin, T; Csajka, C | 1 |
| Fujita, H; Itoh, H; Nakagawa, M; Nakamura, K; Nakata, T; Sasaki, S; Takeda, K; Takenaka, K; Uchida, A | 1 |
| Hama, J; Horiuchi, M; Kai, T; Kamoi, K; Kino, H; Nagata, S; Shimada, S; Sugimura, K; Takenaka, T; Yamamoto, Y | 1 |
| Arendshorst, WJ; Best, CF; Coffman, TM; Kim, HS; Oliverio, MI; Smithies, O | 1 |
| Fukai, D; Kinoshita, M; Maeda, Y; Tsutamoto, T; Wada, A | 1 |
| Abe, J; Deguchi, J; Kurokawa, K; Makuuchi, M; Matsumoto, T; Noda, M; Ohno, M; Takuwa, N; Takuwa, Y | 1 |
| Azizi, M; Chatellier, G; Ménard, J | 1 |
| Högemann, AM; Hübner, R; Riddell, JG; Sunzel, M | 1 |
| Belz, GG; Fuchs, B; Magin, SG; Malerczyk, C; Mutschler, E; Roll, S | 1 |
| Fukuda, R; Imura, Y; Matsuo, T; Nagano, H; Nishikawa, K; Noda, M; Ohta, M; Shibouta, Y | 1 |
| Akagi, Y; Ando, A; Hori, M; Horio, M; Imai, E; Kawada, N; Moriyama, T; Nagata, K; Yamauchi, A | 1 |
| Goligorsky, MS; Kornfeld, M; Moore, LC; Thorup, C; Winaver, JM | 1 |
| Champion, HC; Garrison, EA; Kadowitz, PJ | 1 |
| Iwao, H; Kim, S | 1 |
| Brilla, CG; Rupp, H; Scheer, C | 1 |
| Andersson, OK; Neldam, S | 1 |
| Cervenka, L; Navar, LG; Wang, CT | 1 |
| Champion, HC; Kadowitz, PJ; Lambert, DG | 1 |
| Belz, GG; Breithaupt-Grögler, K; Butzer, R; Fuchs, B; Herrmann, V; Högemann, A; Magin, SG; Malerczyk, C; Mutschler, E; Roll, S; Voith, B | 1 |
| Okumura, K; Ra, C; Ravetch, JV; Shirato, I; Suzuki, Y; Takai, T; Tomino, Y | 1 |
| Andersson, OK; Friberg, P; Fridman, K; Sunzel, M; Wysocki, M | 1 |
| Andersson, OK | 1 |
| Cook, AK; Deichmann, PC; Imig, JD; Inscho, EW | 1 |
| Chung, O; Csikós, T; Unger, T | 1 |
| Inada, Y; Kanagawa, R; Misumi, Y; Naka, T; Nishikawa, K; Ojima, M | 1 |
| Hamada, M; Hashida, H; Hiwada, K | 1 |
| Buter, H; de Jong, PE; de Zeeuw, D; Navis, GY; Woittiez, AJ | 1 |
| Azizi, M; Chatellier, G; Guyene, TT; Ménard, J | 1 |
| Abe, I; Fujishima, M; Kagiyama, S; Matsumura, K; Tsuchihashi, T | 1 |
| Inada, Y; Kubo, K; Naka, T; Nishikawa, K | 1 |
| Arens, H; Bouzo, H; George, M; Münz, J; Pethig, H; Petr, P; Riegger, GA; Spacek, R; von Behren, V | 1 |
| Dell'Oro, R; Grassi, G; Mancia, G; Turri, C | 1 |
| Hayashi, I; Katada, J; Majima, M; Muramatsu, M | 1 |
| Kaul, AF; McVoy, HJ; Stoukides, CA | 1 |
| Komuro, I; Yamazaki, T; Yazaki, Y | 1 |
| See, S; Stirling, AL | 1 |
| Bonarjee, VV; Dickstein, K | 1 |
| Inada, Y; Naka, T | 1 |
| Inada, Y; Nishikawa, K; Ojima, M; Sanada, T; Shibouta, Y; Wada, T | 1 |
| Kromer, EP | 1 |
| Grassi, G; Mancia, G | 1 |
| Azizi, M; Belz, GG; Unger, T | 1 |
| Badguet, JP; Mallion, JM | 1 |
| Akao, M; Horie, M; Kouchi, I; Murakami, T; Otani, H; Sakurai, T; Sasayama, S; Takano, M | 1 |
| Littmann, L; Stell, LK | 1 |
| Burnier, M | 1 |
| Hara, K; Kobayashi, N; Matsuoka, H; Mori, Y; Nakano, S; Tsubokou, Y | 1 |
| Hayashi, M; Nakaya, H; Saruta, T; Sasamura, H | 1 |
| Imura, Y; Matsuo, T; Nagano-Tsuge, H; Naka, T; Noda, M; Ohta, M; Sekiguchi, M; Shibouta, Y | 1 |
| Ito, H; Kawai, J; Suzuki, T; Takemori, K | 1 |
| Paull, JR; Widdop, RE | 1 |
| Kobayashi, N; Kobayashi, T; Matsuoka, H; Mori, Y; Nakano, S; Shirataki, H; Tsubokou, Y | 1 |
| Nakamura, A; Niimi, R; Yanagawa, Y | 1 |
| Easthope, SE; Jarvis, B | 1 |
| Culman, J; Gohlke, P; Jürgensen, T; Kox, T; Rascher, W; Unger, T; Von Kügelgen, S | 1 |
| Imaki, T; Naruse, M; Sato, A; Takagi, S; Takano, K; Tanabe, A; Tsuchiya, K | 1 |
| Ariff, B; Augst, A; Barratt, D; Glor, F; Hughes, A; Poulter, N; Sever, P; Stanton, A; Thom, SA; Xu, Y | 1 |
| Henrion, D; Levy, BI; Matrougui, K; Widdop, RE | 1 |
| Ikehara, K; Inokuchi, T; Kuboki, K; Tada, H | 1 |
| Alegria, E; Arens, HA; Dabrowski, M; Dukát, A; Kiowski, W; Lenz, K; Marks, DS; Miric, M; Mitrovic, V; Seferovic, P; Spinar, J; Willenbrock, R | 1 |
| Ando, H; Furugori, K; Harata, T; Mizutani, S; Murata, Y; Shibata, D | 1 |
| Matsumori, A; Miyamoto, T; Sasayama, S; Shioi, T; Uchiyama, K; Yamamoto, K | 1 |
| Azizi, M; Bissery, A; Lamarre-Cliche, M; Ménard, J | 1 |
| Cook, AK; Imig, JD; Inscho, EW; Murzynowski, JB | 1 |
| Boer, P; Gaillard, CA; Rabelink, TJ; Willemsen, JM | 1 |
| Black, MJ; Jones, ES; Widdop, RE | 1 |
| Austin, C; Bermann, G; Heagerty, AM; Izzard, A; Malik, RA; Schofield, IJ | 1 |
| Fujita, M; Fukamizu, A; Hayashi, I; Itoman, M; Majima, M; Yamashina, S | 1 |
| Aizawa, Y; Inoue, M; Kashimura, T; Kodama, M; Ma, M; Saito, Y; Shirai, K; Suresh, PS; Tachikawa, H; Wahed, MI; Watanabe, K | 1 |
| Ishiguro, K; Itoh, H; Sakamaki, Y; Saruta, T; Sasamura, H | 1 |
| Hibi, T; Horikawa, H; Ishii, H; Kitamura, K; Kumagai, N; Kurita, S; Nakamoto, N; Saito, H; Tada, S; Toda, K; Tsunematsu, S | 1 |
| Anderson, WP; Bertram, JF; Cullen-McEwen, LA; Denton, KM; Evans, RG; Fitzgerald, SM; Kett, MM; Shweta, A | 1 |
| Fukumoto, M; Hayashi, T; Ikeda, T; Jin, D; Kitaura, Y; Miyazaki, M; Oku, H; Sugiyama, T; Takai, S | 1 |
| Jamous, MA; Kitazato, KT; Nagahiro, S; Tada, Y; Tamura, T; Uno, M; Yagi, K | 1 |
| Fu, H; Hosomi, N; Itano, T; Kohno, M; Liu, G; Masugata, H; Matsumoto, M; Miki, T; Nakano, D; Nishiyama, A; Pelisch, N; Sueda, Y; Ueno, M | 1 |
| Arozal, W; Arumugam, S; Giridharan, VV; Harima, M; Kodama, M; Palaniyandi, SS; Sari, FR; Soetikno, V; Suzuki, K; Thandavarayan, RA; Watanabe, K | 1 |
| Abe, K; Abe, S; Furusu, A; Hayashi, W; Io, K; Kohno, S; Koji, T; Miyazaki, M; Nishino, T; Obata, Y; Sugaya, T | 1 |
| Azegami, T; Hayashi, K; Itoh, H; Nakamura, M; Oguchi, H; Sakamaki, Y; Sasamura, H; Tokuyama, H; Wakino, S | 1 |
| Chen, H; Chen, YX; Deng, TT; Zhao, XY | 1 |
| Belfiore, A; Cammalleri, M; Chiurazzi, M; Colantuoni, A; Dal Monte, M; Damiano, S; De Conno, B; Di Maro, M; Guida, B; Lapi, D; Mondola, P; Nasti, G; Santillo, M; Serao, N; Trio, R | 1 |
21 review(s) available for angiotensin ii and candesartan cilexetil
| Article | Year |
|---|---|
Angiotensin II antagonists DuP 753 and TCV 116.
Topics: Administration, Oral; Angiotensin II; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Humans; Hypertension; Imidazoles; Losartan; Renin-Angiotensin System; Tetrazoles | 1994 |
Immunomodulating agents for the management of heart failure with myocarditis and cardiomyopathy--lessons from animal experiments.
Topics: Adjuvants, Immunologic; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Cardiomyopathy, Dilated; Cardiotonic Agents; Cardiovirus Infections; Cytokines; Encephalomyocarditis virus; Heart Failure; Humans; Mice; Myocarditis; Prodrugs; Pyrazines; Quinolines; Tetrazoles; Tumor Necrosis Factor-alpha | 1995 |
Pharmacokinetic-pharmacodynamic relationships of three angiotensin II receptor antagonists in normal volunteers.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Imidazoles; Irbesartan; Losartan; Prodrugs; Reference Values; Tetrazoles | 1996 |
Pharmacokinetic-pharmacodynamic profile of angiotensin II receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Clinical Trials as Topic; Humans; Imidazoles; Losartan; Renin; Tetrazoles; Valine; Valsartan | 1997 |
Do we need angiotensin II antagonists to treat hypertensive patients?
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Humans; Hypertension; Tetrazoles | 1997 |
Involvement of angiotensin II in cardiovascular and renal injury: effects of an AT1-receptor antagonist on gene expression and the cellular phenotype.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cardiomegaly; Fibronectins; Gene Expression; Humans; Hypertension; Nephrosclerosis; Proto-Oncogene Proteins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Tetrazoles | 1997 |
Tolerability of a modern antihypertensive agent: candesartan cilexetil.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Losartan; Prodrugs; Randomized Controlled Trials as Topic; Tetrazoles | 1998 |
Angiotensin II receptor pharmacology and AT1-receptor blockers.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Thiophenes | 1999 |
Pharmacologic properties of candesartan cilexetil--possible mechanisms of long-acting antihypertensive action.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Circadian Rhythm; Humans; Hypertension; Muscle Contraction; Muscle, Smooth, Vascular; Rabbits; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles | 1999 |
A new class of diacidic nonpeptide angiotensin II receptor antagonists: candesartan cilexetil.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Binding, Competitive; Biological Availability; Biphenyl Compounds; Blood Pressure; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Structure-Activity Relationship; Tetrazoles; Time Factors | 1999 |
Candesartan cilexetil: an angiotensin II receptor blocker.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Hypertension; Tetrazoles | 1999 |
Role of the renin-angiotensin system in cardiac hypertrophy.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cardiomegaly; Cell Division; Cells, Cultured; Hydralazine; Hypertension; Mitogen-Activated Protein Kinases; Myocardium; Protein-Tyrosine Kinases; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; Signal Transduction; Sodium-Hydrogen Exchangers; Tetrazoles | 1999 |
Candesartan cilexetil: an angiotensin II-receptor blocker.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Hypertension; Prodrugs; Randomized Controlled Trials as Topic; Tetrazoles | 2000 |
[Use of angiotensin II receptor blockaders in heart failure].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Drug Therapy, Combination; Heart Failure; Humans; Irbesartan; Randomized Controlled Trials as Topic; Tetrazoles; Valine; Valsartan | 2000 |
[Candesartan cilexetil: pharmacological properties and protective effects against organ damage of a novel nonpeptide angiotensin II-receptor antagonist].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Heart Failure; Humans; Kidney Diseases; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles | 2000 |
[Angiotensin-II-receptor antagonists for cardiac insufficiency].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Captopril; Dose-Response Relationship, Drug; Drug Therapy, Combination; Heart Failure; Humans; Losartan; Randomized Controlled Trials as Topic; Tetrazoles | 2000 |
The role of angiotensin II receptor antagonists in hypertension management: focus on candesartan cilexetil.
Topics: Adult; Age Factors; Aged; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cardiovascular Diseases; Clinical Trials as Topic; Female; Follow-Up Studies; Humans; Hypertension; Life Style; Male; Middle Aged; Patient Compliance; Practice Guidelines as Topic; Prevalence; Prodrugs; Prospective Studies; Risk; Risk Factors; Sex Factors; Tetrazoles; Time Factors; World Health Organization | 2000 |
Blocking the tissue renin-angiotensin system: the future cornerstone of therapy.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cardiovascular System; Dogs; Heart; Humans; Hypertension; In Vitro Techniques; Kidney; Prodrugs; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Renin-Angiotensin System; Tetrazoles; Time Factors | 2000 |
Putting the efficacy of candesartan cilexetil into perspective: a review of new comparative data.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cattle; Cerebellum; Circadian Rhythm; Female; Heart; Humans; Hypertension; In Vitro Techniques; Irbesartan; Kinetics; Losartan; Male; Middle Aged; Prodrugs; Rabbits; Randomized Controlled Trials as Topic; Receptors, Angiotensin; Renin; Tetrazoles; Time Factors | 2000 |
Angiotensin II type 1 receptor blockers.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; Blood Pressure; Drug Design; Humans; Irbesartan; Losartan; Peptidyl-Dipeptidase A; Protein Binding; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; Saralasin; Tetrazoles; Valine; Valsartan | 2001 |
Candesartan cilexetil: an update of its use in essential hypertension.
Topics: Adsorption; Age Factors; Aged; Angiotensin II; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Black People; Diabetes Mellitus, Type 2; Drug Interactions; Humans; Hypertension; Hypertrophy, Left Ventricular; Kidney; Renal Insufficiency; Tetrazoles; Treatment Outcome | 2002 |
20 trial(s) available for angiotensin ii and candesartan cilexetil
| Article | Year |
|---|---|
Effects of angiotensin receptor antagonist and angiotensin converting enzyme inhibitor on insulin sensitivity in fructose-fed hypertensive rats and essential hypertensives.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Glucose; Blood Pressure; Diet; Fructose; Glucose Clamp Technique; Humans; Hypertension; Indans; Insulin Resistance; Male; Middle Aged; Rats; Rats, Sprague-Dawley; Tetrazoles | 1995 |
Characterization of the angiotensin II receptor antagonist TCV-116 in healthy volunteers.
Topics: Administration, Oral; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Renin; Tetrazoles | 1995 |
Role of the renin-angiotensin system in hypertension in the elderly.
Topics: Adult; Aged; Aging; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Enalapril; Humans; Hypertension; Middle Aged; Prodrugs; Renin; Renin-Angiotensin System; Tetrazoles | 1994 |
Development and validation of column-switching high-performance liquid chromatographic methods for the determination of a potent AII receptor antagonist, TCV-116, and its metabolites in human serum and urine.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biological Availability; Biphenyl Compounds; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Quality Control; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tetrazoles | 1995 |
Persistent inhibition of the pressor and aldosterone responses to angiotensin-II by TCV-116 in normotensive subjects.
Topics: Administration, Oral; Adult; Aldosterone; Analysis of Variance; Angiotensin II; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Humans; Male; Receptors, Angiotensin; Reference Values; Renin-Angiotensin System; Tetrazoles | 1995 |
Quantitation of a new potent angiotensin II receptor antagonist, TCV-116, and its metabolites in human serum and urine.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Male; Prodrugs; Reproducibility of Results; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tetrazoles | 1996 |
Pharmacokinetics of candesartan after single and repeated doses of candesartan cilexetil in young and elderly healthy volunteers.
Topics: Adult; Age Factors; Aged; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Tetrazoles | 1997 |
The antihypertensive effect and tolerability of candesartan cilexetil, a new generation angiotensin II antagonist, in comparison with losartan.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Losartan; Male; Middle Aged; Tetrazoles; Treatment Outcome | 1998 |
Angiotensin II antagonism and plasma radioreceptor-kinetics of candesartan in man.
Topics: Administration, Oral; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Male; Prodrugs; Rats; Receptors, Angiotensin; Tetrazoles | 1998 |
Acute effects of candesartan cilexetil (the new angiotensin II antagonist) on systemic and renal haemodynamics in hypertensive patients.
Topics: Acute-Phase Reaction; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Female; Hemodynamics; Humans; Hypertension; Kidney; Male; Middle Aged; Prodrugs; Renal Circulation; Renin; Tetrazoles; Vasodilation | 1998 |
Pharmacokinetics and pharmacodynamics of candesartan cilexetil in patients with normal to severely impaired renal function.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Female; Humans; Hypertension; Kidney; Kidney Diseases; Male; Middle Aged; Prodrugs; Renin; Tetrazoles | 1999 |
Pharmacokinetic-pharmacodynamic interactions of candesartan cilexetil and losartan.
Topics: Administration, Oral; Adolescent; Adult; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Humans; Losartan; Male; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Tetrazoles | 1999 |
Improvement in exercise tolerance and symptoms of congestive heart failure during treatment with candesartan cilexetil. Symptom, Tolerability, Response to Exercise Trial of Candesartan Cilexetil in Heart Failure (STRETCH) Investigators.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cardiovascular Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Dyspnea; Exercise Test; Exercise Tolerance; Fatigue; Female; Heart Failure; Humans; Hypotension; Male; Middle Aged; Prospective Studies; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Severity of Illness Index; Tetrazoles | 1999 |
Comparison of angiotensin II receptor blockers: impact of missed doses of candesartan cilexetil and losartan in systemic hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Data Interpretation, Statistical; Drug Administration Schedule; Humans; Hypertension; Hypertrophy, Left Ventricular; Losartan; Middle Aged; Patient Compliance; Randomized Controlled Trials as Topic; Tetrazoles; Treatment Outcome | 1999 |
Use of placebo in heart failure research.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Heart Failure; Helsinki Declaration; Humans; Patient Compliance; Placebos; Tetrazoles | 2000 |
Comparison of the effects of antihypertensive treatment with angiotensin II blockade and beta-blockade on carotid wall structure and haemodynamics: protocol and baseline demographics.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin II; Antihypertensive Agents; Arteriosclerosis; Atenolol; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Carotid Artery, Common; Cerebrovascular Circulation; Double-Blind Method; Female; Humans; Image Processing, Computer-Assisted; Laser-Doppler Flowmetry; Male; Manometry; Middle Aged; Models, Cardiovascular; Tetrazoles; Ultrasonography | 2002 |
Acute and 3-month treatment effects of candesartan cilexetil on hemodynamics, neurohormones, and clinical symptoms in patients with congestive heart failure.
Topics: Adolescent; Adult; Aged; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Atrial Natriuretic Factor; Benzimidazoles; Biphenyl Compounds; Double-Blind Method; Female; Follow-Up Studies; Heart Failure; Hemodynamics; Hormones; Humans; Male; Middle Aged; Placebos; Prodrugs; Regression Analysis; Renin; Tetrazoles; Treatment Outcome | 2003 |
Integrating drug pharmacokinetics for phenotyping individual renin response to angiotensin II blockade in humans.
Topics: Administration, Oral; Adolescent; Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Area Under Curve; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Diet, Sodium-Restricted; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Furosemide; Genetic Variation; Humans; Juxtaglomerular Apparatus; Male; Renin; Renin-Angiotensin System; Reproducibility of Results; Tetrazoles; Valine; Valsartan | 2004 |
Disparate systemic and renal blocking properties of angiotensin II antagonists during exogenous angiotensin II administration: implications for treatment.
Topics: Adult; Aged; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Child; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hemodynamics; Humans; Hypertension; Kidney; Losartan; Middle Aged; Renal Circulation; Renin; Tetrazoles | 2004 |
Effects of angiotensin type-1 receptor antagonism on small artery function in patients with type 2 diabetes mellitus.
Topics: Acetylcholine; Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Arteries; Benzimidazoles; Biphenyl Compounds; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Male; Middle Aged; Nitroprusside; Tetrazoles; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
86 other study(ies) available for angiotensin ii and candesartan cilexetil
| Article | Year |
|---|---|
Role of angiotensin II in the transforming growth factor-beta 1 expression of rat kidney in anti-glomerular basement membrane antiserum-induced glomerulonephritis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Basement Membrane; Benzimidazoles; Biphenyl Compounds; Glomerulonephritis; Kidney; Kidney Cortex; Kidney Glomerulus; Male; Proteinuria; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetrazoles; Transforming Growth Factor beta | 1995 |
Comparable effects of angiotensin II and converting enzyme blockade on hemodynamics and cardiac hypertrophy in spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Cardiac Output; Cardiomegaly; Heart; Hemodynamics; Hypertension; Kidney; Lisinopril; Male; Organ Size; Rats; Rats, Inbred SHR; Rats, Wistar; Renal Circulation; Tetrazoles | 1995 |
Effects of the non-peptide angiotensin II receptor antagonist TCV-116 on systemic and renal hemodynamics in dogs with renal hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Enalapril; Heart Rate; Hemodynamics; Hypertension, Renal; Kidney Function Tests; Male; Renal Circulation; Renin; Tetrazoles | 1995 |
Effects of TCV-116 and CV-11974 on angiotensin II-induced responses in vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; Muscle, Smooth, Vascular; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Tetrazoles | 1995 |
Angiotensin II type I receptor antagonist inhibits the gene expression of transforming growth factor-beta 1 and extracellular matrix in cardiac and vascular tissues of hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Benzimidazoles; Biphenyl Compounds; Cardiomegaly; Enalapril; Extracellular Matrix Proteins; Gene Expression Regulation; Hypertension; Male; Mesenteric Arteries; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Tetrazoles; Transforming Growth Factor beta | 1995 |
Regression of left ventricular hypertrophy prevents ischemia-induced lethal arrhythmias. Beneficial effect of angiotensin II blockade.
Topics: Angiotensin II; Animals; Arrhythmias, Cardiac; Benzimidazoles; Biphenyl Compounds; Body Weight; Captopril; Dose-Response Relationship, Drug; Hypertrophy, Left Ventricular; Male; Myocardial Ischemia; Organ Size; Rats; Rats, Inbred SHR; Tetrazoles | 1995 |
Role of angiotensin II in cerebrovascular and renal damage in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Brain; Desoxycorticosterone; Disease Models, Animal; Enalapril; Hypertension; Kidney; Male; Rats; Rats, Wistar; Receptors, GABA-A; Renin-Angiotensin System; Sodium Chloride; Tetrazoles | 1995 |
Angiotensin II type 1 receptor blockade inhibits the expression of immediate-early genes and fibronectin in rat injured artery.
Topics: Angioplasty, Balloon; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arteries; Base Sequence; Benzimidazoles; Biphenyl Compounds; Collagen; Fibronectins; Gene Expression Regulation; Genes, Immediate-Early; Immunohistochemistry; Male; Molecular Sequence Data; Ornithine Decarboxylase; Rats; Rats, Sprague-Dawley; Tetrazoles; Transforming Growth Factor beta | 1995 |
Chronic administration of angiotensin II receptor antagonist, TCV-116, in cardiomyopathic hamsters.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Cardiomyopathies; Cricetinae; Guinea Pigs; Hypertrophy; Male; Mesocricetus; Myocardium; Pressure; Renin-Angiotensin System; Tetrazoles; Ventricular Function, Left | 1994 |
Contribution of renal angiotensin II type I receptor to gene expressions in hypertension-induced renal injury.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Enalapril; Extracellular Matrix Proteins; Gene Expression; Hemodynamics; Hypertension; Kidney; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; RNA, Messenger; Tetrazoles; Transforming Growth Factor beta | 1994 |
Angiotensin II Receptor Antagonists: Can they Go Beyond ACE Inhibitors? Proceedings of a satellite symposium to the 15th scientific meeting of the International Society of Hypertension. Melbourne, Australia, March 1994.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Humans; Hypertension; Tetrazoles | 1994 |
Renal protective effect of TCV-116 in stroke-prone spontaneously hypertensive rats.
Topics: Albuminuria; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cerebrovascular Disorders; Extracellular Matrix; Gene Expression; Hypertension, Renal; Kidney; Kidney Glomerulus; Male; Phenotype; Prodrugs; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; RNA, Messenger; Sclerosis; Tetrazoles; Transforming Growth Factor beta | 1994 |
Angiotensin II receptor antagonist, TCV-116, prevents myocardial hypertrophy in spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cardiomegaly; Endomyocardial Fibrosis; Hypertension; Iodine Radioisotopes; Kinetics; Myocardium; Prodrugs; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Tetrazoles | 1994 |
An angiotensin II receptor antagonist reduces myocardial damage in an animal model of myocarditis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Body Weight; Cardiovirus Infections; Disease Models, Animal; Encephalomyocarditis virus; Heart; Male; Mice; Mice, Inbred DBA; Myocarditis; Myocardium; Organ Size; Survival Analysis; Tetrazoles; Virus Replication | 1994 |
Effect of an angiotensin II receptor antagonist, CV-11974, and its prodrug, TCV-116, on production of aldosterone.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Corticosterone; Hypertension; Imidazoles; Infusions, Intravenous; Male; Pyridines; Rabbits; Rats; Rats, Inbred SHR; Rats, Wistar; Tetrazoles; Zona Glomerulosa | 1994 |
Cardioprotective effect of the angiotensin II type 1 receptor antagonist TCV-116 on ischemia-reperfusion injury.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Coronary Circulation; Creatine Kinase; Heart; Heart Rate; Heart Ventricles; Indans; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Tetrazoles; Ventricular Pressure | 1994 |
Role of angiotensin II in renal injury of deoxycorticosterone acetate-salt hypertensive rats.
Topics: Angiotensin II; Animals; Benzimidazoles; Biphenyl Compounds; Collagen; Desoxycorticosterone; Enalapril; Hypertension; Kidney; Kidney Diseases; Male; Organ Size; Rats; Rats, Wistar; Renin; RNA, Messenger; Sodium Chloride; Tetrazoles; Transforming Growth Factor beta | 1994 |
Effect of angiotensin II type 1 receptor antagonist on urinary prostaglandin E2 excretion following furosemide in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Dinoprostone; Furosemide; Imidazoles; Indans; Losartan; Male; Prodrugs; Rats; Rats, Wistar; Tetrazoles | 1994 |
The role of activated vascular angiotensin II generation in vascular hypertrophy in one-kidney, one clip hypertensive rats.
Topics: Actins; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta, Thoracic; Benzimidazoles; Biphenyl Compounds; DNA; Hydralazine; Hypertension, Renovascular; Hypertrophy; Indans; Male; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Tetrazoles | 1993 |
Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Hydralazine; Hypertension; Hypertrophy, Left Ventricular; Male; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin-Angiotensin System; Signal Transduction; Tetrazoles | 1994 |
TCV-116, a newly developed angiotensin II receptor antagonist, induces regression of cardiac hypertrophy through suppression of the tissue renin-angiotensin system in spontaneously hypertensive rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensins; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Heart Atria; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Male; Organ Size; Rats; Rats, Inbred SHR; Renin; Tetrazoles | 1994 |
Contribution of cardiac renin-angiotensin system to ventricular remodelling in myocardial-infarcted rats.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Hemodynamics; Indans; Male; Myocardial Infarction; Myocardium; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles | 1993 |
Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethy
Topics: Adrenal Cortex; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cattle; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prodrugs; Protein Binding; Rabbits; Rats; Rats, Sprague-Dawley; Substrate Specificity; Tetrazoles | 1993 |
TCV-116, a novel angiotensin II receptor antagonist, prevents intimal thickening and impairment of vascular function after carotid injury in rats.
Topics: Acetylcholine; Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Carotid Arteries; Carotid Artery Diseases; Catheterization; Cell Division; Disease Models, Animal; DNA; Endothelium, Vascular; Male; Microscopy, Electron, Scanning; Muscle Relaxation; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Tetrazoles; Tunica Intima | 1993 |
Role of angiotensin II in high fructose-induced left ventricular hypertrophy in rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Fructose; Hypertrophy, Left Ventricular; Male; Rats; Rats, Sprague-Dawley; Tetrazoles | 1993 |
Angiotensin blockade and the progression of renal damage in the spontaneously hypertensive rat.
Topics: Albuminuria; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Chromatography, High Pressure Liquid; Hydralazine; Hypertension; Indans; Kidney; Male; Proteinuria; Rats; Rats, Inbred SHR; Survival Analysis; Tetrazoles | 1993 |
Inhibition by angiotensin II type 1 receptor antagonist of cardiac phenotypic modulation after myocardial infarction.
Topics: Actins; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Base Sequence; Benzimidazoles; Biphenyl Compounds; DNA, Complementary; Gene Expression; Male; Molecular Sequence Data; Myocardial Infarction; Myosin Heavy Chains; Rats; Rats, Wistar; Tetrazoles; Transforming Growth Factor beta | 1995 |
Angiotensin II receptor antagonist TCV-116 reduces graft coronary artery disease and preserves graft status in a murine model. A comparative study with captopril.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Coronary Disease; Graft Rejection; Graft Survival; Heart Transplantation; Hyperplasia; Male; Mice; Mice, Inbred DBA; Myocardium; Tetrazoles; Transplantation, Homologous | 1996 |
Angiotensin II-dependent down-regulation of vascular natriuretic peptide type C receptor gene expression in hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Down-Regulation; Guanylate Cyclase; Hypertension; Male; Muscle, Smooth, Vascular; Natriuretic Peptide, C-Type; Nitrobenzenes; Piperazines; Proteins; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Atrial Natriuretic Factor; RNA, Messenger; Tetrazoles | 1996 |
CV-11974, the active metabolite of TCV-116 (Candesarten), inhibits the synergistic or additive effect of different growth factors on angiotensin II-induced proliferation of vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Becaplermin; Benzimidazoles; Biphenyl Compounds; Cell Division; Cells, Cultured; Drug Synergism; Epidermal Growth Factor; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Inbred WKY; Tetrazoles | 1996 |
General pharmacological properties of the new angiotensin II receptor antagonist (+/-)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate. Part I: Effects on central nervous system and
Topics: Analgesics; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autonomic Nervous System; Benzimidazoles; Biphenyl Compounds; Body Temperature; Cats; Central Nervous System; Digestive System; Electroencephalography; Female; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Motor Activity; Muscles; Rabbits; Rats; Rats, Sprague-Dawley; Sleep; Synaptic Transmission; Tetrazoles | 1996 |
Disposition of the new angiotensin II receptor antagonist candesartan cilexetil in rats and dogs.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Bile; Biological Availability; Biphenyl Compounds; Dogs; Feces; Half-Life; Intestinal Absorption; Male; Rats; Rats, Wistar; Tetrazoles; Tissue Distribution | 1996 |
Role of angiotensin II in reflex tachycardia during hypotension caused by a calcium channel blocker.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Dihydropyridines; Enalapril; Hemodynamics; Hypotension; Nitrobenzenes; Piperazines; Propranolol; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reflex; Tachycardia; Tachycardia, Sinus; Telemetry; Tetrazoles; Time Factors | 1996 |
Characterization of conjugated metabolites of a new angiotensin II receptor antagonist, candesartan cilexetil, in rats by liquid chromatography/electrospray tandem mass spectrometry following chemical derivatization.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Bile; Biotransformation; Biphenyl Compounds; Chromatography, Liquid; Glucuronates; Male; Mass Spectrometry; Methylation; Rats; Rats, Wistar; Tetrazoles | 1996 |
Carbocyclic thromboxane A2 enhances the angiotensin II-induced DNA synthesis in smooth muscle cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cell Division; Cells, Cultured; DNA; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred WKY; RNA, Messenger; Tetrazoles; Thromboxane A2; Vasoconstrictor Agents | 1996 |
General pharmacological properties of the new angiotensin II receptor antagonist (+/-)-1-(cyclohexyloxycarbonyloxy) ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl] methyl]-1 H-benzimidazole-7-carboxylate. Part II: Effect on cardiovascular system a
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Diuretics; Dogs; Guinea Pigs; Heart Rate; Hemodynamics; Hydrochlorothiazide; In Vitro Techniques; Kidney; Male; Potassium; Rats; Rats, Inbred Strains; Regional Blood Flow; Respiratory Mechanics; Sodium; Sodium Chloride Symporter Inhibitors; Tetrazoles; Urodynamics | 1996 |
Angiotensin II as a stimulator of Na(+)-dependent Ca2+ efflux from freshly isolated adult rat cardiomyocytes.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Calcium; Calcium Radioisotopes; Dose-Response Relationship, Drug; Imidazoles; Losartan; Male; Muscle Fibers, Skeletal; Myocardium; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium; Tetrazoles | 1996 |
Combined effects of the angiotensin II antagonist candesartan cilexetil (TCV-116) and other classes of antihypertensive drugs in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin II; Animals; Antihypertensive Agents; Atenolol; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Dihydropyridines; Diuretics; Drug Therapy, Combination; Hydrochlorothiazide; Male; Nitrobenzenes; Piperazines; Prazosin; Rats; Rats, Inbred SHR; Renin; Sodium Chloride Symporter Inhibitors; Tetrazoles | 1996 |
Role of nitric oxide in impaired coronary circulation and improvement by angiotensin II receptor antagonist in spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Coronary Circulation; Enzyme Inhibitors; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles | 1995 |
Effect of an angiotensin II receptor antagonist, TCV-116, on neointimal formation following balloon injury in the SHR carotid artery.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Carotid Arteries; Carotid Artery Injuries; Catheterization; Heart Rate; Lisinopril; Male; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles | 1995 |
Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Enalapril; Hexamethonium; Imidazoles; Kidney; Losartan; Mice; Mice, Knockout; Phentolamine; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin; RNA, Messenger; Sympatholytics; Tetrazoles; Time Factors; Transcription, Genetic | 1997 |
Chronic effects of ANG II antagonist in heart failure: improvement of cGMP generation from ANP.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Benzimidazoles; Biphenyl Compounds; Cyclic GMP; Dogs; Female; Glomerular Filtration Rate; Heart Failure; Hemodynamics; Kidney; Male; Norepinephrine; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles; Time Factors; Vascular Resistance | 1997 |
Stimulated activation of platelet-derived growth factor receptor in vivo in balloon-injured arteries: a link between angiotensin II and intimal thickening.
Topics: Amlodipine; Angioplasty, Balloon; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Carotid Artery Injuries; Carotid Artery, Common; ErbB Receptors; Insulin Receptor Substrate Proteins; Male; Phosphoproteins; Phosphorylation; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Receptors, Angiotensin; Receptors, Platelet-Derived Growth Factor; Tetrazoles; Tunica Intima; Tyrosine | 1997 |
Inhibition of angiotensin II pressor response and ex vivo angiotensin II radioligand binding by candesartan cilexetil and losartan in healthy human volunteers.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Double-Blind Method; Humans; Losartan; Male; Tetrazoles | 1997 |
Effects of candesartan cilexetil (TCV-116) and enalapril in 5/6 nephrectomized rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Disease Progression; Enalapril; Fibrosis; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Kidney Failure, Chronic; Male; Nephrectomy; Proteinuria; Rats; Rats, Sprague-Dawley; Tetrazoles; Transforming Growth Factor beta | 1997 |
TCV-116 inhibits interstitial fibrosis and HSP47 mRNA in rat obstructive nephropathy.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Collagen; Fibrosis; Heat-Shock Proteins; Histocytochemistry; HSP47 Heat-Shock Proteins; Male; Prodrugs; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetrazoles; Ureteral Obstruction | 1997 |
Angiotensin-II stimulates nitric oxide release in isolated perfused renal resistance arteries.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Electric Conductivity; Endothelium, Vascular; Losartan; Male; Microelectrodes; Nitric Oxide; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renal Artery; Tetrazoles; Vascular Resistance | 1998 |
[Pro11,D-Ala12]angiotensin I has rapid onset vasoconstrictor activity in the cat.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Cats; Female; Hindlimb; Imidazoles; Male; Norepinephrine; Pyridines; Receptors, Angiotensin; Tetrazoles; Time Factors; Vasoconstrictor Agents | 1997 |
Renin-angiotensin system and myocardial collagen matrix: modulation of cardiac fibroblast function by angiotensin II type 1 receptor antagonism.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Calcium; Cells, Cultured; Collagen; DNA Primers; Dose-Response Relationship, Drug; Fibroblasts; Intracellular Fluid; Myocardium; Polymerase Chain Reaction; Prodrugs; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; RNA, Messenger; Tetrazoles | 1997 |
Effects of acute AT1 receptor blockade by candesartan on arterial pressure and renal function in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Glomerular Filtration Rate; Kidney; Male; Prodrugs; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renal Circulation; Tetrazoles | 1998 |
Inhibitory effects of candesartan on responses to angiotensin peptides in the hindquarters vascular bed of the cat.
Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cats; Dose-Response Relationship, Drug; Female; Hindlimb; Male; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Vasoconstriction | 1998 |
Distinct contribution of Fc receptors and angiotensin II-dependent pathways in anti-GBM glomerulonephritis.
Topics: Actins; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Basement Membrane; Benzimidazoles; Biphenyl Compounds; Disease Models, Animal; Female; Glomerulonephritis; Kidney Glomerulus; Macrophages; Male; Mice; Mice, Knockout; Monocytes; Proteinuria; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, IgG; Tetrazoles | 1998 |
Candesartan cilexetil protects against loss of autoregulatory efficiency in angiotensin II-infused rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Homeostasis; Hypertension; Kidney; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles; Vasoconstriction | 1999 |
Serial changes in sarcoplasmic reticulum gene expression in volume-overloaded cardiac hypertrophy in the rat: effect of an angiotensin II receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blotting, Northern; Calcium-Binding Proteins; Calcium-Transporting ATPases; Calsequestrin; Gene Expression; Hypertrophy, Left Ventricular; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Tetrazoles; Ventricular Function, Left | 1999 |
Effects of chronic oral treatment with imidapril and TCV-116 on the responsiveness to angiotensin II in ventrolateral medulla of SHR.
Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Hypertension; Imidazoles; Imidazolidines; Male; Medulla Oblongata; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Tetrazoles; Vasoconstrictor Agents | 1999 |
[Involvement of chymase in angiogenesis in hamster sponge granulomas].
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Chymases; Chymotrypsin; Cricetinae; Endothelial Growth Factors; Granuloma; Hemoglobins; Humans; Lymphokines; Male; Mesocricetus; Neovascularization, Physiologic; Oligopeptides; Protein Isoforms; Serine Endopeptidases; Serine Proteinase Inhibitors; Tetrazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats.
Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Bradykinin; Enalapril; Enzyme Activation; Hypertension, Renal; Male; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Artery; Surgical Instruments; Tetrazoles; Vasoconstrictor Agents | 1996 |
Angiotensin II type 1 receptor blockade abolishes specific K(ATP)channel gene expression in rats with myocardial ischemia.
Topics: Angiotensin I; Angiotensin II; Animals; Benzimidazoles; Biphenyl Compounds; Blotting, Northern; Blotting, Western; DNA, Complementary; Lisinopril; Male; Myocardial Ischemia; Myocardium; Natriuretic Peptide, Brain; Potassium Channels; Potassium Channels, Inwardly Rectifying; Random Allocation; Rats; Rats, Wistar; Renin-Angiotensin System; RNA; RNA, Messenger; Tetrazoles; Time Factors; Up-Regulation | 2000 |
Effects of TCV-116 on endothelin-1 and PDGF A-chain expression in angiotensin II-induced hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Body Weight; Collagen; Endothelin Receptor Antagonists; Endothelin-1; Heart Ventricles; Hemodynamics; Hypertension; Male; Organ Size; Platelet-Derived Growth Factor; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, Endothelin A; Receptors, Endothelin; Reverse Transcriptase Polymerase Chain Reaction; Tetrazoles; Ventricular Remodeling | 2001 |
Temporary treatment of prepubescent rats with angiotensin inhibitors suppresses the development of hypertensive nephrosclerosis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cardiomegaly; Gene Expression; Genetic Predisposition to Disease; Hydralazine; Hypertension; Indans; Kidney; Male; Nephrosclerosis; Proteinuria; Rats; Rats, Inbred SHR; Renin; Stroke; Tetrazoles; Time Factors; Vasodilator Agents | 2001 |
Involvement of angiotensin II in progression of renal injury in rats with genetic non-insulin-dependent diabetes mellitus (Wistar fatty rats).
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cholesterol; Creatinine; Diabetes Mellitus, Type 2; Disease Progression; Enalapril; Glomerular Mesangium; Male; Proteins; Proteinuria; Rats; Rats, Wistar; Rats, Zucker; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Tetrazoles; Triglycerides | 2001 |
AT1 receptor antagonist prevents brain edema without lowering blood pressure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Brain Edema; Cerebral Cortex; Hypertension; Male; Prodrugs; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrazoles | 2000 |
Persistent cardiovascular effects of chronic renin-angiotensin system inhibition following withdrawal in adult spontaneously hypertensive rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blood Vessels; Cardiomegaly; Cardiovascular System; Drug Administration Schedule; Heart Rate; Hydralazine; Hypertension; Kidney; Male; Motor Activity; Perindopril; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Tetrazoles; Vasodilator Agents | 2001 |
TCV-116 stimulates eNOS and caveolin-1 expression and improves coronary microvascular remodeling in normotensive and angiotensin II-induced hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arterioles; Benzimidazoles; Biphenyl Compounds; Capillaries; Caveolin 1; Caveolins; Collagen Type I; Coronary Vessels; Gene Expression; Hypertension; Male; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Rats; Rats, Inbred WKY; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazoles | 2001 |
Suppression of endotoxin-induced renal tumor necrosis factor-alpha and interleukin-6 mRNA by renin-angiotensin system inhibitors.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Benzimidazoles; Biphenyl Compounds; Blotting, Northern; Cytokines; Enalapril; Endotoxins; Gene Expression Regulation; Interleukin-6; Kidney; Lipopolysaccharides; Male; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; RNA, Messenger; Tetrazoles; Tumor Necrosis Factor-alpha | 2002 |
Effects of orally applied candesartan cilexetil on central responses to angiotensin II in conscious rats.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine Vasopressin; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Brain; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Tetrazoles | 2002 |
Aldosterone breakthrough during angiotensin II receptor antagonist therapy in stroke-prone spontaneously hypertensive rats.
Topics: Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; Corticosterone; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation; Hypertension; Imidazoles; Male; Natriuretic Peptide, Brain; Prodrugs; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Spironolactone; Stroke; Tetrazoles; Time Factors | 2002 |
AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Culture Techniques; Dose-Response Relationship, Drug; Kinetics; Male; Mesenteric Arteries; Oligopeptides; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reproducibility of Results; Tetrazoles; Vasoconstrictor Agents; Vasodilation | 2002 |
Role of protein kinase C-angiotensin II pathway for extracellular matrix production in cultured human mesangial cells exposed to high glucose levels.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Collagen Type IV; Culture Media; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix; Glomerular Mesangium; Glucose; Humans; Indoles; Maleimides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Tetrazoles; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vasoconstrictor Agents | 2003 |
Dual renin-angiotensin blockade therapy in patients at high risk of early ovarian hyperstimulation syndrome receiving IVF and elective embryo cryopreservation: a case series.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Captopril; Chorionic Gonadotropin; Cryopreservation; Drug Therapy, Combination; Embryo Transfer; Embryo, Mammalian; Estradiol; Female; Fertilization in Vitro; Humans; Ovarian Hyperstimulation Syndrome; Renin; Renin-Angiotensin System; Risk Factors; Tetrazoles | 2003 |
Attenuation of virus-induced myocardial injury by inhibition of the angiotensin II type 1 receptor signal and decreased nuclear factor-kappa B activation in knockout mice.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Cardiovirus Infections; Encephalomyocarditis virus; Heart; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocarditis; Myocardium; NF-kappa B; Receptor, Angiotensin, Type 1; RNA, Messenger; Tetrazoles; Tumor Necrosis Factor-alpha | 2003 |
Elevated arterial pressure impairs autoregulation independently of AT(1) receptor activation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Drug Therapy, Combination; Homeostasis; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Reserpine; Tetrazoles; Time Factors; Vasoconstriction; Vasoconstrictor Agents | 2004 |
Angiotensin AT2 receptor contributes to cardiovascular remodelling of aged rats during chronic AT1 receptor blockade.
Topics: Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Aorta; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cardiomegaly; Fibrosis; Heart Rate; Hypertrophy; Imidazoles; Myocardium; Pyridines; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 2; Telemetry; Tetrazoles; Ventricular Remodeling | 2004 |
Angiotensin type 1a receptor signaling-dependent induction of vascular endothelial growth factor in stroma is relevant to tumor-associated angiogenesis and tumor growth.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Fibroblasts; Lisinopril; Mice; Mice, Inbred ICR; Mice, Knockout; Neovascularization, Pathologic; NF-kappa B; Peptidyl-Dipeptidase A; Protein Kinase C; Receptor, Angiotensin, Type 1; Sarcoma; Signal Transduction; Tetrazoles; Transcription Factor AP-1; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2005 |
Effects of angiotensin-II receptor blocker candesartan cilexetil in rats with dilated cardiomyopathy.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoimmune Diseases; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cardiomyopathy, Dilated; Cardiotonic Agents; Collagen Type III; Male; Myocarditis; Myocardium; Rats; Rats, Inbred Lew; RNA, Messenger; Tetrazoles; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation | 2005 |
Developmental activity of the renin-angiotensin system during the "critical period" modulates later L-NAME-induced hypertension and renal injury.
Topics: Aging; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biomarkers; Biphenyl Compounds; Blood Pressure; Cardiovascular System; Critical Period, Psychological; Drug Administration Schedule; Enzyme Inhibitors; Hypertension; Kidney; Male; Mortality; NG-Nitroarginine Methyl Ester; Oxidative Stress; Proteinuria; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin-Angiotensin System; Tetrazoles; Vasoconstrictor Agents | 2007 |
Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis.
Topics: Alanine Transaminase; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aspartate Aminotransferases; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Choline Deficiency; Disease Models, Animal; DNA Damage; Fatty Liver; Liver; Liver Cirrhosis; Male; Organ Size; Oxidative Stress; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Signal Transduction; Tetrazoles; Time Factors; Tumor Necrosis Factor-alpha | 2007 |
Glomerular surface area is normalized in mice born with a nephron deficit: no role for AT1 receptors.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; Dose-Response Relationship, Drug; Heart Rate; Heterozygote; Hypertrophy; Kidney Glomerulus; Male; Mice; Mice, Inbred C57BL; Organ Size; Receptor, Angiotensin, Type 1; Tetrazoles | 2009 |
Long-term angiotensin II blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis.
Topics: Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fibrosis; Heart Failure; Hyperglycemia; Male; Myocardium; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Tetrazoles | 2009 |
Endothelial damage due to impaired nitric oxide bioavailability triggers cerebral aneurysm formation in female rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Base Sequence; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Corrosion Casting; DNA Primers; Endothelium, Vascular; Estradiol; Estrogen Replacement Therapy; Female; Humans; Hypertension; Intracranial Aneurysm; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Ovariectomy; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetrazoles | 2009 |
Therapeutic effects of postischemic treatment with hypotensive doses of an angiotensin II receptor blocker on transient focal cerebral ischemia.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Brain; Brain Edema; Brain Ischemia; Hypotension; Ischemia; Rats; Rats, Sprague-Dawley; Tetrazoles; Time Factors | 2011 |
Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autoimmune Diseases; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Cell Survival; Endoplasmic Reticulum Stress; Heart Diseases; Immunohistochemistry; In Situ Nick-End Labeling; Male; Myocarditis; Myosins; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Inbred Lew; Receptors, G-Protein-Coupled; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Tetrazoles | 2012 |
Glomerular repair retardation via blocking of angiotensin II type 1a receptor pathway in a mouse glomerulonephritis model.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Collagen Type IV; Crotalid Venoms; Disease Models, Animal; Glomerulonephritis; Kidney Glomerulus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Signal Transduction; Tetrazoles; Trimeresurus; Vascular Endothelial Growth Factor A | 2012 |
Renin-angiotensin blockade resets podocyte epigenome through Kruppel-like Factor 4 and attenuates proteinuria.
Topics: Albuminuria; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Cell Line; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Doxorubicin; Epigenesis, Genetic; Irbesartan; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Male; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; Podocytes; Promoter Regions, Genetic; Renal Insufficiency, Chronic; Renin-Angiotensin System; Signal Transduction; Tetrazoles; Time Factors; Transfection | 2015 |
Angiotensin II is a crucial factor in retinal aneurysm formation.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blood-Retinal Barrier; Blotting, Western; Coloring Agents; Disease Models, Animal; Fluorescein Angiography; Indocyanine Green; Interleukin-1beta; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, Platelet-Derived Growth Factor beta; Retinal Arterial Macroaneurysm; Retinal Artery; Tetrazoles; Tomography, Optical Coherence; Vasoconstrictor Agents | 2021 |
The Effects of Angiotensin II or Angiotensin 1-7 on Rat Pial Microcirculation during Hypoperfusion and Reperfusion Injury: Role of Redox Stress.
Topics: Angiotensin I; Angiotensin II; Animals; Benzimidazoles; Biphenyl Compounds; Female; Male; Microcirculation; Microscopy, Fluorescence; Peptide Fragments; Pia Mater; Proto-Oncogene Mas; Rats; Reactive Oxygen Species; Reperfusion Injury; Tetrazoles | 2021 |