angiotensin ii has been researched along with atorvastatin in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (38.64) | 29.6817 |
| 2010's | 26 (59.09) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Bäumer, AT; Böhm, M; Konkol, C; Laufs, U; Müller, K; Nickenig, G; Sauer, H; Wassmann, S | 1 |
| Böhm, M; Kilter, H; Konkol, C; Laufs, U; Nickenig, G; Wassmann, S | 1 |
| Hatta, T; Irie, H; Kameyama, H; Kusaba, T; Kuwahara, N; Matsubara, H; Narumiya, H; Sasaki, S; Takeda, K; Tamagaki, K | 1 |
| Ahishali, B; Arican, N; Bilgic, B; Elmas, I; Kalayci, R; Kaya, M; Kucuk, M; Kudat, H; Uzun, H | 1 |
| Bailey, M; Denver, R; Krum, H; Martin, J | 1 |
| Boonstra, PW; Buikema, H; Morshuis, WJ; Nickenig, G; Plokker, HW; Six, AJ; van der Harst, P; van Gilst, WH; van Veldhuisen, DJ; Voors, AA; Wagenaar, LJ; Wassmann, S | 1 |
| Liu, YX; Sheng, L; Ye, P | 1 |
| Hirase, T; Inoue, T; Node, K; Wang, D | 1 |
| Hirano, H; Morishita, T; Nakashima, Y; Nakata, S; Ozumi, K; Sabanai, K; Sasaguri, Y; Shimokawa, H; Suda, O; Tanimoto, A; Tasaki, H; Tsutsui, M; Yamashita, T; Yanagihara, N | 1 |
| Bech, JN; Holm, C; Paulsen, L; Pedersen, EB; Starklint, J | 1 |
| Carvajal-González, G; Egido, J; Mezzano, S; Ortiz, A; Rodrigues Díez, R; Rodrigues-Díez, R; Rodríguez-Vita, J; Ruiz-Ortega, M; Sánchez-López, E; Selgas, R | 1 |
| Bech, JN; Holst, LM; Paulsen, L; Pedersen, EB; Starklint, J | 1 |
| Abraldes, JG; Arroyo, V; Bataller, R; Colmenero, J; Dominguez, M; Egido, J; Ginès, P; Moreno, M; Ramalho, F; Ramalho, LN; Ruiz-Ortega, M; Sancho-Bru, P | 1 |
| Fukumoto, Y; Rashid, M; Seto, M; Shimokawa, H; Tawara, S; Yano, K | 1 |
| Alonso, MJ; Briones, AM; Egido, J; García-Redondo, AB; Hernanz, R; Rodrigues-Díez, RR; Rodríguez-Criado, N; Ruiz-Ortega, M; Salaices, M | 1 |
| Cui, W; Ibi, M; Ikami, K; Iwata, K; Kakehi, T; Katsuyama, M; Matsuno, K; Sasaki, M; Yabe-Nishimura, C; Zhu, K | 1 |
| Fan, Y; Lu, JP; Ren, JH; Zhang, XS | 1 |
| Kino, T; Matsuzawa, Y; Nishikawa, T; Omura, M; Saito, J; Suematsu, S | 1 |
| Civantos, E; Egido, J; Lavoz, C; Mezzano, S; Ortiz, A; Rayego-Mateos, S; Rodrigues Díez, R; Rodrigues-Díez, R; Rodríguez-Vita, J; Ruiz-Ortega, M | 1 |
| Bi, H; Chen, WA; Daugherty, A; Hong, B; Luo, Y; Wang, JA; Wang, Y; Xie, X; Zhang, S | 1 |
| Aubin, MC; Carrier, M; Forcillo, J; Maltais, S; Perrault, LP; Shi, YF; Tardif, JC | 1 |
| Chen, SC; Cheng, WP; Hung, HF; Shyu, KG; Wang, BW | 1 |
| Fukumoto, Y; Kudo, S; Liao, JK; Minami, T; Nochioka, K; Shiba, N; Shimokawa, H; Takai, Y; Tanaka, S; Williams, CL | 1 |
| Bu, L; Cheng, Z; Dong, D; Huang, T; Shen, B; Tu, Y; Wan, L; Zhao, D | 1 |
| Andersson, O; Bergh, N; Grote, L; Hrafnkelsdóttir, TJ; Saluveer, O; Widgren, BR | 1 |
| Do e, Z; Fukumoto, Y; Kanazawa, M; Matsumoto, Y; Sato, A; Satoh, K; Shimizu, T; Shimokawa, H; Takahashi, K | 1 |
| Arévalo, M; Docherty, NG; Eleno, N; Fuentes-Calvo, I; Grande, MT; López-Novoa, JM; Pérez-Barriocanal, F; Rodríguez-Peña, AB | 1 |
| Chen, Z; Ge, J; Ma, Y; Zou, Y | 1 |
| Hui, L; Xiao-Ping, G; Yi, R | 1 |
| Chen, J; Hu, YJ; Peng, DF; Tang, SY | 1 |
| Kong, L; Ma, Y; Qi, S; Wang, D | 1 |
| Pantan, R; Suksamrarn, A; Tocharus, C; Tocharus, J | 1 |
| Han, CG; Liu, YX; Sheng, L; Yang, X; Ye, P | 1 |
| Chang, Y; Guo, X; Li, Y; Li, Z; Sun, G; Sun, Y; Ye, N | 2 |
| Chang, Y; Chen, S; Chen, Y; Li, Y; Sun, G; Sun, Y; Yu, S; Zhang, N | 1 |
| Li, Y; Lu, G; Sun, D; Wang, DW; Yan, J; Zuo, H | 1 |
| Choi, SY; Kim, CR; Kim, MH; Park, JS; Roh, MS; Serebruany, V | 1 |
| Liu, G; Yang, C; Yang, H; Yang, P; Yang, S; Zhao, D; Zheng, H | 1 |
| Liu, D; Nie, W; Shi, K; Xie, D; Yang, P; Yu, B; Zhang, H | 1 |
| Cheng, WP; Chua, SK; Lo, HM; Shyu, KG; Wang, BW | 1 |
| Belin de Chantemele, EJ; Bruder-Nascimento, T; Callera, GE; Montezano, AC; Tostes, RC; Touyz, RM | 1 |
| Cao, Z; Du, X; Li, X; Sun, Z; Wang, D; Wang, K; Zhou, X; Zuo, G | 1 |
5 trial(s) available for angiotensin ii and atorvastatin
| Article | Year |
|---|---|
Effect of intensive versus moderate lipid lowering on endothelial function and vascular responsiveness to angiotensin II in stable coronary artery disease.
Topics: Aged; Angiotensin II; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Bypass; Coronary Artery Disease; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; In Vitro Techniques; Male; Mammary Arteries; Middle Aged; Prospective Studies; Pyrroles; Treatment Outcome; Vasodilation | 2005 |
Effects of statins on renal sodium and water handling: acute and short-term effects of atorvastatin on renal haemodynamics, tubular function, vasoactive hormones, blood pressure and pulse rate in healthy, normocholesterolemic humans.
Topics: Adult; Angiotensin II; Arginine Vasopressin; Atorvastatin; Atrial Natriuretic Factor; Blood Pressure; Cross-Over Studies; Diuresis; Double-Blind Method; Female; Glomerular Filtration Rate; Heart Rate; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Kidney Tubules; Male; Natriuresis; Natriuretic Peptide, Brain; Pyrroles; Renal Plasma Flow | 2008 |
Glomerular filtration rate and blood pressure are unchanged by increased sodium intake in atorvastatin-treated healthy men.
Topics: Adult; Aldosterone; Angiotensin II; Aquaporin 2; Atorvastatin; Atrial Natriuretic Factor; Blood Pressure; Female; Glomerular Filtration Rate; Heptanoic Acids; Humans; Kidney Function Tests; Lithium; Male; Natriuretic Peptide, Brain; Pyrroles; Renin; Sodium; Vasopressins | 2009 |
Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Angiotensin II; Animals; Atorvastatin; Cells, Cultured; Cross-Over Studies; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Leukocytes; Male; Pravastatin; Pyrroles; Quinolines; rac1 GTP-Binding Protein; ras Proteins; Rats; Rats, Inbred WKY; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2009 |
Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Atorvastatin; Biomarkers; Cardiomegaly; Cells, Cultured; Cholesterol; Cholesterol, LDL; Coronary Vessels; Cross-Over Studies; Cytoskeletal Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Guanine Nucleotide Exchange Factors; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Japan; Male; Mice; Mice, Knockout; Neuropeptides; Oxidative Stress; Phosphatidylinositol 3-Kinase; Pravastatin; Proto-Oncogene Proteins c-akt; Pyrroles; Quinolines; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; RNA Interference; Signal Transduction; Transfection | 2013 |
39 other study(ies) available for angiotensin ii and atorvastatin
| Article | Year |
|---|---|
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase.
Topics: Angiotensin II; Animals; Atorvastatin; Cells, Cultured; Down-Regulation; Free Radicals; Gene Expression; GTP Phosphohydrolases; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Muscle, Smooth, Vascular; Protein Prenylation; Pyrroles; rac1 GTP-Binding Protein; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA Stability; RNA, Messenger | 2001 |
Impact of HMG CoA reductase inhibition on small GTPases in the heart.
Topics: Angiotensin II; Animals; Atorvastatin; Atrial Natriuretic Factor; Cardiac Myosins; Cardiomegaly; Cell Membrane; Cells, Cultured; Gene Expression Regulation; GTP Phosphohydrolases; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Myocardium; Myosin Light Chains; Pyrroles; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; RNA, Messenger; Simvastatin | 2002 |
HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells.
Topics: Amides; Analysis of Variance; Angiotensin II; Atorvastatin; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glucuronidase; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Tubules; Klotho Proteins; Membrane Proteins; Pyridines; Pyrroles; Quinolines; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; RNA, Messenger | 2004 |
Effects of atorvastatin on blood-brain barrier permeability during L-NAME hypertension followed by angiotensin-II in rats.
Topics: Angiotensin II; Animals; Atorvastatin; Blood-Brain Barrier; Heptanoic Acids; Hypertension; Male; NG-Nitroarginine Methyl Ester; Permeability; Pyrroles; Rats; Rats, Wistar | 2005 |
In vitro inhibitory effects of atorvastatin on cardiac fibroblasts: implications for ventricular remodelling.
Topics: Angiotensin II; Animals; Atorvastatin; Cells, Cultured; Collagen; Connective Tissue Growth Factor; Dose-Response Relationship, Drug; Extracellular Matrix; Fibroblasts; Heart; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Myocardium; Procollagen; Pyrroles; Rats; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ventricular Remodeling | 2005 |
[Atorvastatin upregulates the expression of PPAR alpha/gamma and inhibits the hypertrophy of cardiac myocytes in vitro].
Topics: Angiotensin II; Animals; Atorvastatin; Cardiomegaly; Cells, Cultured; Gene Expression Regulation; Heptanoic Acids; Myocytes, Cardiac; PPAR alpha; PPAR-beta; Pyrroles; Rats; Rats, Wistar; Up-Regulation | 2005 |
Atorvastatin inhibits angiotensin II-induced T-type Ca2+ channel expression in endothelial cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Atorvastatin; Benzimidazoles; Biphenyl Compounds; Calcium Channels, T-Type; Cells, Cultured; Endothelial Cells; Flavonoids; Gene Expression; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Microscopy, Fluorescence; Pyrroles; ras Proteins; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tetrazoles; Vasoconstrictor Agents | 2006 |
Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway.
Topics: Angiotensin II; Animals; Atorvastatin; Cells, Cultured; Endothelin-1; Gene Expression Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oncogene Protein v-akt; Pyrroles; Rats; Rats, Sprague-Dawley; Up-Regulation | 2007 |
Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways.
Topics: Angiotensin II; Atorvastatin; Cell Line; Cell Transdifferentiation; Connective Tissue Growth Factor; Epithelial Cells; Fibrosis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinase Kinases; Phenotype; Protein Kinase Inhibitors; Pyrroles; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Time Factors; Transfection | 2008 |
Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Atorvastatin; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Hepatic Stellate Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Infusion Pumps, Implantable; Intercellular Adhesion Molecule-1; Interleukin-6; Liver; Male; Oxidative Stress; Pyrroles; Rats; Rats, Wistar; Transforming Growth Factor beta1 | 2009 |
Atorvastatin prevents angiotensin II-induced vascular remodeling and oxidative stress.
Topics: Angiotensin II; Animals; Atorvastatin; Blood Pressure; Blotting, Western; Cells, Cultured; Collagen; Elasticity; Extracellular Matrix; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Malondialdehyde; Mesenteric Arteries; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type III; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Superoxide Dismutase; Superoxides; Vasoconstrictor Agents | 2009 |
NADPH oxidase isoforms and anti-hypertensive effects of atorvastatin demonstrated in two animal models.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Apolipoproteins E; Atorvastatin; Blood Pressure; Blotting, Western; Dietary Fats; Ethidium; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Nitric Oxide Synthase; Pyrroles; rac1 GTP-Binding Protein; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Atorvastatin protects against angiotensin II-induced injury and dysfunction in human umbilical vein endothelial cells through bradykinin 2 receptors.
Topics: Angiotensin II; Apoptosis; Atorvastatin; Cell Line; Endothelial Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide Synthase Type III; Pyrroles; Receptor, Bradykinin B2; Umbilical Veins | 2010 |
Effect of atorvastatin on aldosterone production induced by glucose, LDL or angiotensin II in human renal mesangial cells.
Topics: Aldosterone; Angiotensin II; Anticholesteremic Agents; Atorvastatin; Cytochrome P-450 CYP11B2; Diabetic Nephropathies; Glucose; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Mesangial Cells; Pyrroles; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process.
Topics: Angiotensin II; Animals; Aorta; Atorvastatin; Blotting, Western; Cells, Cultured; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Simvastatin; Smad Proteins; Transforming Growth Factor beta; Vasoconstrictor Agents | 2010 |
Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms.
Topics: Angiotensin II; Animal Feed; Animals; Anti-Inflammatory Agents; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Atorvastatin; Blood Pressure; Fluorobenzenes; Gene Expression Regulation; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Mice; Mice, Inbred C57BL; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides | 2011 |
Atorvastatin worsens left ventricular diastolic dysfunction and endothelial dysfunction of epicardial coronary arteries in normocholesterolemic porcine with left ventricular hypertrophy.
Topics: Angiotensin II; Animals; Aorta; Atorvastatin; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Echocardiography; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Male; Nitrates; Nitrites; Pyrroles; Random Allocation; Swine; Vasodilation; Ventricular Dysfunction, Left | 2011 |
Mechanism of the inhibitory effect of atorvastatin on leptin expression induced by angiotensin II in cultured human coronary artery smooth muscle cells.
Topics: Angiotensin II; Anticholesteremic Agents; Atorvastatin; Blotting, Western; Cell Movement; Cell Proliferation; Cells, Cultured; Coronary Vessels; Heptanoic Acids; Humans; JNK Mitogen-Activated Protein Kinases; Leptin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Pyrroles; rac1 GTP-Binding Protein; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Vasoconstrictor Agents | 2012 |
MicroRNA-22 downregulation by atorvastatin in a mouse model of cardiac hypertrophy: a new mechanism for antihypertrophic intervention.
Topics: Angiotensin II; Animals; Anticholesteremic Agents; Atorvastatin; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Down-Regulation; Heptanoic Acids; Male; Mice; MicroRNAs; Myocardium; Myocytes, Cardiac; Myosin Heavy Chains; Natriuretic Peptide, Brain; Oligonucleotides, Antisense; Phosphoric Monoester Hydrolases; PTEN Phosphohydrolase; Pyrroles; Rats | 2013 |
Acute vascular effects of atorvastatin in hypertensive men: a pilot study.
Topics: Angiotensin II; Atorvastatin; Endothelium, Vascular; Forearm; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Middle Aged; Pilot Projects; Pyrroles; Regional Blood Flow; Vasoconstriction; Vasodilation | 2013 |
Combination therapy with atorvastatin and amlodipine suppresses angiotensin II-induced aortic aneurysm formation.
Topics: Amlodipine; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apoptosis; Atorvastatin; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Drug Therapy, Combination; Enzyme Activation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lipids; Male; Matrix Metalloproteinases; Mice; Mice, Knockout; Pyrroles; rho-Associated Kinases | 2013 |
Effect of angiotensin II and small GTPase Ras signaling pathway inhibition on early renal changes in a murine model of obstructive nephropathy.
Topics: Angiotensin II; Animals; Atorvastatin; Disease Models, Animal; Fibrosis; Heptanoic Acids; Humans; Kidney; Kidney Diseases; Mice; Monomeric GTP-Binding Proteins; Pyrroles; Receptor, Angiotensin, Type 1; Signal Transduction; Ureteral Obstruction | 2014 |
Atorvastatin represses the angiotensin 2-induced oxidative stress and inflammatory response in dendritic cells via the PI3K/Akt/Nrf 2 pathway.
Topics: Angiotensin II; Animals; Anticholesteremic Agents; Atorvastatin; Bone Marrow Cells; Cell Proliferation; Cells, Cultured; Cytokines; Dendritic Cells; Heptanoic Acids; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2014 |
Atorvastatin prevents angiotensin II-induced high permeability of human arterial endothelial cell monolayers via ROCK signaling pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Arteries; Atorvastatin; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Heptanoic Acids; Humans; Lim Kinases; Permeability; Phosphorylation; Pyrroles; rho-Associated Kinases; Signal Transduction; Zonula Occludens-1 Protein | 2015 |
Protective effects of valsartan and benazepril combined with atorvastatin on cardiorenal syndrome in rats.
Topics: Angiotensin II; Animals; Atorvastatin; Benzazepines; C-Reactive Protein; Cardio-Renal Syndrome; Case-Control Studies; Drug Synergism; Heptanoic Acids; Lipids; Male; Natriuretic Peptide, Brain; Proteinuria; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Tetrazoles; Valine; Valsartan | 2015 |
Atorvastatin blocks increased l-type Ca2+ current and cell injury elicited by angiotensin II via inhibiting oxide stress.
Topics: Angiotensin II; Animals; Animals, Newborn; Atorvastatin; Calcium Channels, L-Type; Cell Line; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2016 |
Synergistic effect of atorvastatin and Cyanidin-3-glucoside on angiotensin II-induced inflammation in vascular smooth muscle cells.
Topics: Angiotensin II; Anthocyanins; Anti-Inflammatory Agents; Atherosclerosis; Atorvastatin; Cell Proliferation; Cells, Cultured; Drug Evaluation, Preclinical; Drug Synergism; Enzyme Induction; Glucosides; Humans; Intercellular Adhesion Molecule-1; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Vascular Cell Adhesion Molecule-1; Vasculitis | 2016 |
Effect of Atorvastatin on Expression of Peroxisome Proliferator-activated Receptor Beta/delta in Angiotensin II-induced Hypertrophic Myocardial Cells In Vitro.
Topics: Angiotensin II; Animals; Atorvastatin; Cardiomegaly; Cells, Cultured; Hydroxymethylglutaryl-CoA Reductase Inhibitors; PPAR delta; PPAR-beta; Rats; Rats, Wistar | 2015 |
Atorvastatin inhibits the apoptosis of human umbilical vein endothelial cells induced by angiotensin II via the lysosomal-mitochondrial axis.
Topics: Angiotensin II; Apoptosis; Atorvastatin; Cytochromes c; Human Umbilical Vein Endothelial Cells; Humans; Lysosomes; Mitochondria; Reactive Oxygen Species; Signal Transduction | 2016 |
Atorvastatin prevents Angiotensin II induced myocardial hypertrophy in vitro via CCAAT/enhancer-binding protein β.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anticholesteremic Agents; Apoptosis; Atorvastatin; bcl-2-Associated X Protein; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Gene Expression Regulation; Membrane Potential, Mitochondrial; Mitochondria; Myocytes, Cardiac; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction | 2017 |
Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Atorvastatin; Calcium Chloride; Cell Line; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Random Allocation | 2017 |
Inhibition of Angiotensin II-Induced Cardiac Fibrosis by Atorvastatin in Adiponectin Knockout Mice.
Topics: Adiponectin; AMP-Activated Protein Kinases; Angiotensin II; Animals; Atorvastatin; Collagen Type I; Collagen Type III; Fibrosis; Gene Expression Regulation; Gene Knockout Techniques; Heart Diseases; Injections, Subcutaneous; Male; Mice; Phosphorylation; Treatment Outcome | 2017 |
Atorvastatin protects the proliferative ability of human umbilical vein endothelial cells inhibited by angiotensin II by changing mitochondrial energy metabolism.
Topics: Angiotensin II; Apoptosis; Atorvastatin; Cell Proliferation; Electron Transport; Energy Metabolism; Glycolysis; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Phosphorylation; Reactive Oxygen Species; Signal Transduction | 2018 |
Atorvastatin Attenuates Metabolic Remodeling in Ischemic Myocardium through the Downregulation of UCP2 Expression.
Topics: Angiotensin II; Animals; Atorvastatin; Coronary Vessels; Disease Models, Animal; Energy Metabolism; Gene Expression Regulation; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Rats; Uncoupling Protein 2 | 2018 |
Anti-hypertrophy effect of atorvastatin on myocardium depends on AMPK activation-induced miR-143-3p suppression via Foxo1.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Apoptosis; Atorvastatin; Cell Line; Cell Survival; Disease Models, Animal; Hypertrophy, Left Ventricular; Male; MicroRNAs; Myocytes, Cardiac; Nerve Tissue Proteins; Rats, Sprague-Dawley; Signal Transduction; Ventricular Function, Left; Ventricular Remodeling | 2018 |
Effect of atorvastatin on cardiomyocyte hypertrophy through suppressing MURC induced by volume overload and cyclic stretch.
Topics: Angiotensin II; Animals; Anticholesteremic Agents; Arteriovenous Shunt, Surgical; Atorvastatin; Cardiomegaly; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Male; Muscle Proteins; Myocytes, Cardiac; Rats; Rats, Wistar; Signal Transduction; Stress, Mechanical | 2019 |
Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress.
Topics: Aldosterone; Angiotensin II; Animals; Antioxidants; Atorvastatin; Cells, Cultured; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Oxidation-Reduction; Oxidative Stress; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; RAC2 GTP-Binding Protein; Rats; Rats, Inbred WKY; Reactive Oxygen Species; Signal Transduction | 2019 |
Atorvastatin regulates vascular smooth muscle cell phenotypic transformation by epigenetically modulating contractile proteins and mediating Akt/FOXO4 axis.
Topics: Angiotensin II; Animals; Atorvastatin; Becaplermin; Cell Proliferation; Contractile Proteins; Forkhead Transcription Factors; Muscle, Smooth, Vascular; Phenotype; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction | 2022 |