Page last updated: 2024-08-22

angiotensin ii and aliskiren

angiotensin ii has been researched along with aliskiren in 71 studies

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	16 (22.54)	29.6817
2010's	52 (73.24)	24.3611
2020's	3 (4.23)	2.80

Authors

Authors	Studies
Brunner, HR; Jensen, C; Nussberger, J; Wuerzner, G	1
Hollenberg, NK	1
Azizi, M; Bissery, A; Bura-Rivière, A; Camisasca, RP; Guyenne, TT; Ménard, J; Vaidyanathan, S	1
Athyros, VG; Kakafika, AI; Karagiannis, A; Mikhailidis, DP; Tziomalos, K	1
Bobillier, A; Gardner, R; Hillier, C; MacFadyen, R; Mann, J; McDonagh, T; McMurray, J; Murdoch, D; Seed, A	1
Bader, M; Batenburg, WW; Burckle, C; Contrepas, A; Dechend, R; Feldt, S; Fiebeler, A; Jan Danser, AH; Kvakan, H; Luft, FC; Maschke, U; Mazak, I; Muller, DN; Nguyen, G; Wellner, M	1
Dechend, R; Feldt, S; Luft, FC; Maschke, U; Muller, DN	1
Baker, KM; Kumar, R; Singh, VP	1
Dole, WP; Fisher, ND; Hollenberg, NK; Jan Danser, AH; Nussberger, J	1
Baker, KM; Khode, R; Kumar, R; Le, B; Singh, VP	1
Santamaría Olmo, R	1
Boschmann, M; Contrepas, A; Dechend, R; Engeli, S; Graeske, S; Gratze, P; Janke, J; Klaus, S; Luft, FC; Malchow, J; Muller, DN; Nguyen, G; Plehm, R; Qadri, F; Springer, J	1
Ferrario, C; Habibi, J; Hayden, MR; Lastra, G; Manrique, C; Patel, K; Rehmer, J; Sowers, JR; Whaley-Connell, AT	1
Dong, YF; Fukuda, M; Kaneko, T; Kataoka, K; Kim-Mitsuyama, S; Matsuba, S; Nakagata, N; Nakamura, T; Nako, H; Ogawa, H; Tokutomi, Y; Yamamoto, E	1
Ram, CV	1
Danser, AH	1
Ferrario, CM; Habibi, J; Hayden, MR; Johnson, MS; Nistala, R; Rehmer, N; Schneider, RI; Sowers, JR; Tilmon, R; Whaley-Connell, A	1
Savvatis, K; Schultheiss, HP; Tschöpe, C; Westermann, D	1
Ichihara, A; Itoh, H; Kinouchi, K; Kurauchi-Mito, A; Murohashi-Bokuda, K; Narita, T; Nishiyama, A; Sakoda, M; Saleem, MA; Suzuki, F	1
Angeli, F; Garofoli, M; Gentile, G; Martire, P; Mazzotta, G; Reboldi, G; Verdecchia, P	1
Loriga, G	1
Cervenka, L; Husková, Z; Kramer, HJ; Vaněčková, I; Vaňourková, Z	1
Alhenc-Gelas, F; Bouby, N; Bruneval, P; Colucci, J; Griol-Charhbili, V; Krege, JH; Mandet, C; Messadi, E; Richer, C; Smithies, O; Vincent, MP	1
Cervenka, L; Husková, Z; Kramer, HJ; Kujal, P; Mrázová, I; Rakusan, D; Thumová, M; Vanecková, I; Vanourková, Z; Vernerová, Z	1
Azizi, M	1
Howard, CG; Mitchell, KD; Mullins, JJ	1
Campbell, DJ; Gilbert, RE; Kelly, DJ; McCarthy, DJ; Shi, W; Smyth, GK; Zhang, Y	1
Baumann, M; Heemann, U; Hermans, JJ; Lutz, J; Rusai, K; Schmaderer, C	1
Balakrishnan, A; Cassis, LA; Charnigo, R; Daugherty, A; Howatt, DA; Liau, G; Lu, H; Wu, C	1
Janka, R; Ott, C; Raff, U; Ritt, M; Schmieder, RE; Schneider, MP; Uder, M; Veelken, R; Ziegler, T	1
Howard, CG; Huang, L; Mitchell, KD	1
Bi, L; Huang, BS; Leenen, FH; White, RA	1
He, L; Hua, J; Li, Q; Ma, L; Yu, J; Zhou, J	1
Fan, YY; Hitomi, H; Kitada, K; Kobori, H; Lei, B; Masaki, T; Mori, H; Nakano, D; Nishiyama, A	1
Baucke, J; Danser, AH; Divac, N; Fraune, C; Frenay, AR; Garrelds, IM; Hölzel, A; Jankowski, V; Krebs, C; Lange, S; Nguyen, G; Schwedhelm, E; Stahl, R; Streichert, T; van Goor, H; Velden, J; Wenzel, UO	1
Chan, CC; Hsieh, YC; Huang, YH; Lee, KC; Lin, HC; Yang, YY	2
Ahmad, S; Brosnihan, KB; Ferrario, CM; Gomez, RA; Groban, L; Kato, J; Kitamura, K; Lopez, ML; Moniwa, N; Nagata, S; Simington, SW; Varagic, J; VonCannon, JL; Wang, H	1
Endo, M; Fukuda, N; Kobayashi, N; Matsuda, H; Matsumoto, K; Matsumoto, T; Nishiyama, A; Saito, K; Soma, M; Ueno, T; Wang, X; Zhou, X	1
Hashimoto, A; Ishimitsu, T; Matsuoka, H; Numabe, A; Ohba, S; Ohno, E; Ohta, S; Okamura, A; Takahashi, T	1
Ayuzawa, N; Fujita, T; Ishizawa, K; Kawarazaki, W; Nagase, M; Takeuchi, M; Ueda, K; Yoshida, S	1
Baker, KM; Chandel, N; Kumar, R; Seqqat, R; Thomas, CM; Yong, QC	1
Alreja, G; Guan, J; Joseph, J; Luptak, I; Metes-Kosik, N; Shi, J; Zhi, H	1
Azizi, M; Balcarek, J; Bryson, C; Danser, AH; Garrelds, IM; Gregg, R; Griffith, SG; McGeehan, G; Ménard, J; Reeves, RA; Sevá Pessôa, B	1
Golledge, J; Krishna, SM; Liu, D; Moran, CS; Seto, SW	1
Chen, K; Chen, Y; Cheng, L; Li, G; Li, J; Liu, E; Liu, T; Wang, X; Yang, W; Zhao, Z	1
Dursun, N; Kunduz Kindap, E; Ozdogan, K; Taskin, E	1
Bao, Z; Du, Q; Fu, G; Ge, J; Hong, W; Hu, X; Li, H; Qiu, Z; Wang, M; Yao, J; Ye, Y; Zhang, W; Zhao, G	1
Akpinar, E; Bayir, Y; Cadirci, E; Calik, M; Halici, Z; Karakus, E; Polat, B; Topcu, A	1
Cheng, XW; Hamrah, MS; Hao, CN; Hayashi, M; Hu, L; Kuzuya, M; Murohara, T; Shi, GP; Takeshita, K; Wu, H	1
Adanur, S; Akpinar, E; Alkan, E; Bayir, Y; Cadirci, E; Ferah, I; Halici, Z; Karakus, E; Mercantepe, T; Polat, B; Ziypak, T	1
Albayrak, A; Bayir, Y; Halici, Z; Karakus, E; Karcioglu, SS; Mercantepe, T; Palabiyik, SS	1
Chen, S; Levi, M; Li, C; Lin, Y; Luo, R; Wang, F; Wang, W; Yang, T; Zheng, P	1
Balakrishnan, A; Cassis, LA; Chen, X; Crooke, RM; Daugherty, A; Feldman, DL; Graham, MJ; Howatt, DA; Lu, H; Moorleghen, JJ; Mullick, AE; Vander Kooi, CW; Wu, C; Zhao, M	1
Chang, YK; Choi, DE; Chung, S; Jeong, JY; Lee, KW; Lim, BJ; Na, KR	1
Bastiani, FT; Comim, FV; da Rosa, PR; da Silva, EP; Dau, AM; Gonçalves, PB; Gutierrez, K; Ilha, GF	1
Adhikari, S; Alpert, L; Bissonnette, M; Chen, L; Deb, DK; Dougherty, U; Hart, J; He, L; Kwon, J; Li, YC; Liu, SQ; Liu, T; Liu, W; Pekow, J; Rubin, DT; Shi, Y; Wang, J; Zhao, Q; Zhou, G	1
Santos, DF; Silva, GA; Simão, S	1
De Mello, W	1
Dursun, N; Guven, C; Kaya, ST; Taskin, E; Tuncer, KA	1
Feng, P; Kong, Y; Levi, M; Li, C; Li, S; Lin, Y; Liu, Q; Qiu, M; Wang, W; Zhang, T; Zheng, P	1
Alenina, N; Bader, M; Danser, AHJ; Domenig, O; Essers, J; Garrelds, IM; Góes Martini, A; Leijten, FPJ; Paulis, L; Poglitsch, M; Qadri, F; Rajkovicova, R; Severs, D; Te Riet, L; Uijl, E; van der Pluijm, I; van Thiel, BS	1
Boschmann, M; Dahlke, M; Danser, AHJ; Dole, WP; Engeli, S; Jordan, J; May, M; Nussberger, J; Pal, P; Prescott, MF; Stitah, S	1
Chen, JS; Chou, CL; Fang, TC; Lin, H	1
Casarini, DE; Ceron, CS; Fernandes, FB; Guimaraes, DA; Martins-Oliveira, A; Oliveira, DMM; Pinheiro, LC; Rizzi, E; Tanus-Santos, JE; Tirapelli, CR	1
Cabrini, DA; Dietrich, M; Fernandes, D; Horinouchi, CDS; Machado, W; Moreira, CG; Olchanheski, LR; Otuki, MF; Paludo, K; Pawloski, PL	1
Crook, T; Del Carmen Fernandez-Carranco, M; Evans, A; Fleming, C; Hajji, N; Harwood, C; Lattanzio, L; Li, S; Matin, R; Merlano, M; Nigro, CL; O'Neill, K; Proby, C; Rao, B; Renziehausen, A; Sim, VR; Stebbing, J; Syed, N; Szlosarek, P; Thompson, A; Tzakos, AG; Vega-Rioja, A; Wang, H; Weir, L	1
Ding, W; Gan, L; Gao, L; He, H; Li, X; Li, Y; Liu, J; Ou, S; Wang, M; Wu, W	1
Guo, D; Liu, H; Zhao, Z	1
Chevassut, TJ; Milne, KM; Sturrock, BR	1
Pathak, AS; Rojas, M; Stouffer, GA	1

Reviews

8 review(s) available for angiotensin ii and aliskiren

Article	Year
Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution? Expert opinion on pharmacotherapy, 2007, Volume: 8, Issue:5 Topics: Administration, Oral; Aldosterone; Amides; Angiotensin II; Animals; Antihypertensive Agents; Enzyme Activation; Enzyme Reactivators; Fumarates; Heart Failure; Humans; Hypertension; Randomized Controlled Trials as Topic; Renin; Renin-Angiotensin System; Vasoconstrictor Agents	2007
[Therapeutic novelties in the management of arterial hypertension]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2008, Volume: 28 Suppl 5 Topics: Adrenergic beta-Antagonists; Amides; Angiotensin II; Antihypertensive Agents; Baroreflex; Carotid Sinus; Electric Stimulation Therapy; Electrodes, Implanted; Fumarates; Humans; Hypertension; Immunotherapy, Active; Oligopeptides; Randomized Controlled Trials as Topic; Renin; Vaccines, Synthetic	2008
Direct inhibition of renin: a physiological approach to treat hypertension and cardiovascular disease. Future cardiology, 2009, Volume: 5, Issue:5 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Cardiovascular Diseases; Drug Therapy, Combination; Fumarates; Humans; Hypertension; Renin; Renin-Angiotensin System	2009
The increase in renin during renin inhibition: does it result in harmful effects by the (pro)renin receptor? Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:1 Topics: Amides; Angiotensin II; Animals; Antihypertensive Agents; Fumarates; Humans; Prorenin Receptor; Receptors, Cell Surface; Renin	2010
Rational of the use of aliskiren in hypertension and beyond. Minerva cardioangiologica, 2009, Volume: 57, Issue:6 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biphenyl Compounds; Cardiovascular Diseases; Diabetic Nephropathies; Diuretics; Drug Therapy, Combination; Europe; Fumarates; Germany; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; Irbesartan; Japan; Prevalence; Prorenin Receptor; Protein Precursors; Randomized Controlled Trials as Topic; Receptors, Cell Surface; Renin; Renin-Angiotensin System; Risk Factors; Tetrazoles; Time Factors; World Health Organization	2009
Aliskiren versus ramipril in hypertension. Therapeutic advances in cardiovascular disease, 2010, Volume: 4, Issue:3 Topics: Aging; Amides; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Diabetic Angiopathies; Fumarates; Half-Life; Humans; Hypertension; Ramipril; Renin-Angiotensin System	2010
Direct Renin inhibition: promising treatment in renoprotection? Recent patents on cardiovascular drug discovery, 2010, Volume: 5, Issue:2 Topics: Amides; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Chronic Disease; Fumarates; Humans; Kidney Diseases; Rats; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Treatment Outcome	2010
The renin-angiotensin system - a therapeutic target in COVID-19? Clinical medicine (London, England), 2020, Volume: 20, Issue:4 Topics: Amides; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Fumarates; Humans; Lung Injury; Mice; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Renin-Angiotensin System; SARS-CoV-2; Virus Internalization	2020

Trials

8 trial(s) available for angiotensin ii and aliskiren

Article	Year
Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril. Hypertension (Dallas, Tex. : 1979), 2002, Volume: 39, Issue:1 Topics: Administration, Oral; Adult; Aldosterone; Amides; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Enalapril; Fumarates; Heart Rate; Humans; Male; Potassium; Renin; Renin-Angiotensin System; Sodium	2002
Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100). Comparison with enalapril. Current hypertension reports, 2002, Volume: 4, Issue:4 Topics: Administration, Oral; Amides; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Cross-Over Studies; Enalapril; Fumarates; Humans; Renin	2002
Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:12 Topics: Administration, Oral; Adolescent; Adult; Aldosterone; Amides; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Cross-Over Studies; Drug Synergism; Feedback, Physiological; Fumarates; Humans; Male; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2004
Neurohumoral effects of the new orally active renin inhibitor, aliskiren, in chronic heart failure. European journal of heart failure, 2007, Volume: 9, Issue:11 Topics: Aged; Aldosterone; Amides; Analysis of Variance; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Chronic Disease; Female; Fumarates; Heart Failure; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Ramipril; Renin; Statistics, Nonparametric; Treatment Outcome	2007
Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans. Circulation, 2008, Jun-24, Volume: 117, Issue:25 Topics: Administration, Oral; Adult; Amides; Angiotensin I; Angiotensin II; Antihypertensive Agents; Blood Pressure; Captopril; Diet; Dose-Response Relationship, Drug; Female; Fumarates; Glomerular Filtration Rate; Humans; Male; Middle Aged; Natriuresis; Predictive Value of Tests; Reference Values; Renal Circulation; Renal Plasma Flow; Renin; Sodium; Sodium, Dietary; Vasodilation	2008
Long-term antihypertensive effects of aliskiren, a direct renin inhibitor, in chronic hemodialysis patients. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2013, Volume: 17, Issue:5 Topics: Aged; Amides; Angiotensin II; Antihypertensive Agents; Blood Pressure; Female; Fumarates; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Renin; Renin-Angiotensin System; Time Factors; Treatment Outcome	2013
Multiple ascending dose study with the new renin inhibitor VTP-27999: nephrocentric consequences of too much renin inhibition. Hypertension (Dallas, Tex. : 1979), 2014, Volume: 63, Issue:5 Topics: Adolescent; Adult; Aldosterone; Amides; Angiotensin II; Blood Pressure; Carbamates; Dose-Response Relationship, Drug; Female; Fumarates; Hemodynamics; Humans; Kidney; Male; Middle Aged; Piperidines; Renin; Young Adult	2014
Systemic and tissue-specific effects of aliskiren on the RAAS and carbohydrate/lipid metabolism in obese patients with hypertension. Journal of the American Society of Hypertension : JASH, 2017, Volume: 11, Issue:8 Topics: Adipose Tissue; Adult; Amides; Amlodipine; Angiotensin II; Antihypertensive Agents; Blood Glucose; Double-Blind Method; Female; Fumarates; Glucose; Humans; Hypertension; Insulin; Lipolysis; Male; Microdialysis; Middle Aged; Muscle, Skeletal; Obesity; Renin; Renin-Angiotensin System	2017

Other Studies

55 other study(ies) available for angiotensin ii and aliskiren

Article	Year
Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Amides; Angiotensin II; Cells, Cultured; Enzyme Activation; Fumarates; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocytes; Oligopeptides; Peptides; Phosphorylation; Protein Binding; Renin; Signal Transduction; U937 Cells	2008
The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling. Journal of the American Society of Nephrology : JASN, 2008, Volume: 19, Issue:4 Topics: Amides; Angiotensin II; Animals; Blood Pressure; Fumarates; Humans; Hypertension; Muscle, Smooth, Vascular; Oligopeptides; Rats; Renin	2008
Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:4 Topics: Adrenergic beta-Agonists; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Benzazepines; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Cells, Cultured; Collagen Type I; Dose-Response Relationship, Drug; Extracellular Matrix; Fibroblasts; Fumarates; Glucose; Heart Ventricles; Isoproterenol; Microscopy, Confocal; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System; Tetrazoles; Time Factors; Transforming Growth Factor beta; Up-Regulation	2008
Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis. Diabetes, 2008, Volume: 57, Issue:12 Topics: Amides; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Apoptosis; Benzazepines; Benzimidazoles; Biphenyl Compounds; Diabetes Mellitus, Experimental; Endomyocardial Fibrosis; Fumarates; Insulin; Myocytes, Cardiac; Oxidative Stress; Rats; Renin; Tetrazoles	2008
Energy metabolism in human renin-gene transgenic rats: does renin contribute to obesity? Hypertension (Dallas, Tex. : 1979), 2009, Volume: 53, Issue:3 Topics: Adipocytes; Amides; Angiotensin II; Animals; Cells, Cultured; Disease Models, Animal; Energy Metabolism; Fumarates; Humans; Leptin; Lipid Metabolism; Male; Obesity; Phenotype; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Thermogenesis	2009
Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression. Endocrinology, 2009, Volume: 150, Issue:6 Topics: Amides; Angiotensin II; Animals; Animals, Genetically Modified; Disease Models, Animal; Fumarates; Gene Expression Regulation; Glucose; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle, Skeletal; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Renin	2009
Aliskiren enhances the protective effects of valsartan against cardiovascular and renal injury in endothelial nitric oxide synthase-deficient mice. Hypertension (Dallas, Tex. : 1979), 2009, Volume: 54, Issue:3 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiomegaly; Cardiovascular Diseases; Cardiovascular System; Drug Synergism; Drug Therapy, Combination; Fumarates; Gene Expression; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Nitric Oxide Synthase Type III; Receptor, Angiotensin, Type 1; Renin; RNA, Messenger; Superoxides; Tetrazoles; Tunica Intima; Valine; Valsartan	2009
Comparative effect of direct renin inhibition and AT1R blockade on glomerular filtration barrier injury in the transgenic Ren2 rat. American journal of physiology. Renal physiology, 2010, Volume: 298, Issue:3 Topics: Albuminuria; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Blood Pressure; Fumarates; Glomerular Filtration Rate; Hypertension; Irbesartan; Kidney; Membrane Glycoproteins; Membrane Proteins; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Podocytes; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Tetrazoles; Tyrosine	2010
Aliskiren inhibits intracellular angiotensin II levels without affecting (pro)renin receptor signals in human podocytes. American journal of hypertension, 2010, Volume: 23, Issue:5 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Fumarates; Humans; Imidazolidines; Phosphorylation; Podocytes; Prorenin Receptor; Receptors, Cell Surface; Renin; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Tetrazoles	2010
Despite similar reduction of blood pressure and renal ANG II and ET-1 levels aliskiren but not losartan normalizes albuminuria in hypertensive Ren-2 rats. Physiological research, 2010, Volume: 59, Issue:3 Topics: Albuminuria; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Down-Regulation; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Fumarates; Hypertension; Kidney; Losartan; Male; Mice; Pilot Projects; Radioimmunoassay; Rats; Rats, Transgenic; Renin; Time Factors	2010
Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, Volume: 24, Issue:12 Topics: Amides; Angiotensin I; Angiotensin II; Animals; Apoptosis; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Fumarates; Heart; Kinins; Lung; Mice; Mice, Mutant Strains; Myocardial Infarction; Myocardial Ischemia; Myocardium; Peptidyl-Dipeptidase A; Renin; Reperfusion Injury	2010
Persistent antihypertensive effect of aliskiren is accompanied by reduced proteinuria and normalization of glomerular area in Ren-2 transgenic rats. American journal of physiology. Renal physiology, 2010, Volume: 299, Issue:4 Topics: Amides; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Disease Models, Animal; Fumarates; Heart Rate; Hypertension; Kidney Glomerulus; Losartan; Male; Proteinuria; Rats; Rats, Transgenic; Renin; Time Factors	2010
[New modalities of renin-angiotensin system inhibition: Renin inhibitors and active immunization against angiotensin II]. La Revue de medecine interne, 2010, Volume: 31, Issue:10 Topics: Amides; Angiotensin II; Fumarates; Humans; Renin; Renin-Angiotensin System; Vaccination	2010
Direct renin inhibition with aliskiren normalizes blood pressure in Cyp1a1-Ren2 transgenic rats with inducible angiotensin ii-dependent malignant hypertension. The American journal of the medical sciences, 2011, Volume: 341, Issue:5 Topics: Amides; Angiotensin II; Animals; Blood Pressure; Cytochrome P-450 CYP1A1; Disease Models, Animal; Fumarates; Glomerular Filtration Rate; Hypertension, Malignant; Kidney; Male; Rats; Rats, Transgenic; Regional Blood Flow; Renin; Vascular Resistance	2011
Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart. Clinical and experimental pharmacology & physiology, 2011, Volume: 38, Issue:9 Topics: Aldosterone; Amides; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Bradykinin; Female; Fumarates; Heart; Kallikreins; Kidney; Lung; Mice; Myocytes, Cardiac; Perindopril; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Tissue Kallikreins	2011
Direct renin inhibition in a rat model of chronic allograft injury. Transplantation, 2011, Nov-15, Volume: 92, Issue:9 Topics: Amides; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Fumarates; Kidney; Kidney Transplantation; Male; Models, Animal; Peptide Fragments; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Tetrazoles; Transplantation, Homologous	2011
Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolaemia-induced atherosclerosis. British journal of pharmacology, 2012, Volume: 165, Issue:6 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Atherosclerosis; Blood Pressure; Cholesterol; Diet, High-Fat; Enalapril; Fumarates; Hypercholesterolemia; Kidney; Losartan; Male; Mice; Mice, Knockout; Receptor, Angiotensin, Type 1; Receptors, LDL; Renin; Renin-Angiotensin System	2012
Reversibility of the effects of aliskiren in the renal versus systemic circulation. Clinical journal of the American Society of Nephrology : CJASN, 2012, Volume: 7, Issue:2 Topics: Adult; Aged; Aldosterone; Amides; Analysis of Variance; Angiotensin II; Antihypertensive Agents; Blood Pressure; Female; Fumarates; Germany; Half-Life; Humans; Hypertension; Magnetic Resonance Imaging; Male; Middle Aged; Perfusion Imaging; Renal Circulation; Renin; Renin-Angiotensin System; Time Factors; Treatment Outcome; Vasodilation; Vasodilator Agents	2012
Chronic direct renin inhibition with aliskiren prevents the development of hypertension in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent hypertension. The American journal of the medical sciences, 2012, Volume: 344, Issue:4 Topics: Amides; Angiotensin II; Animals; Arterial Pressure; Cytochrome P-450 CYP1A1; Fumarates; Hypertension; Kidney; Male; Rats; Rats, Transgenic; Renin	2012
Central infusion of aliskiren prevents sympathetic hyperactivity and hypertension in Dahl salt-sensitive rats on high salt intake. American journal of physiology. Regulatory, integrative and comparative physiology, 2012, Volume: 302, Issue:7 Topics: Amides; Angiotensin II; Animals; Baroreflex; Blood Pressure; Fumarates; Heart Rate; Hyperkinesis; Hypertension; Infusions, Intraventricular; Male; Rats; Rats, Inbred Dahl; Rats, Wistar; Renin; Sodium Chloride, Dietary; Sympathetic Nervous System	2012
Anti-fibrotic effect of Aliskiren in rats with deoxycorticosterone induced myocardial fibrosis and its potential mechanism. Bosnian journal of basic medical sciences, 2012, Volume: 12, Issue:2 Topics: Amides; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Western; Cardiomyopathies; Cardiotonic Agents; Collagen; Desoxycorticosterone; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Fumarates; Heart Ventricles; Indicators and Reagents; Male; Matrix Metalloproteinase 9; Myocardium; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Renin	2012
Add-on aliskiren elicits stronger renoprotection than high-dose valsartan in type 2 diabetic KKAy mice that do not respond to low-dose valsartan. Journal of pharmacological sciences, 2012, Volume: 119, Issue:2 Topics: Albuminuria; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fumarates; Kidney; Male; Mice; Mice, Inbred C57BL; Renin; RNA, Messenger; Tetrazoles; Valine; Valsartan	2012
AT1 antagonism and renin inhibition in mice: pivotal role of targeting angiotensin II in chronic kidney disease. American journal of physiology. Renal physiology, 2012, Volume: 303, Issue:7 Topics: Albuminuria; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Dose-Response Relationship, Drug; Fumarates; Gene Expression; Kidney; Losartan; Male; Mice; Renal Insufficiency, Chronic; Renin; Renin-Angiotensin System; Treatment Outcome	2012
Aliskiren attenuates chronic carbon tetrachloride-induced liver injury in mice. European journal of clinical investigation, 2012, Volume: 42, Issue:12 Topics: Amides; Angiotensin II; Animals; Antihypertensive Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chronic; Drug Interactions; Fumarates; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Random Allocation; Renin	2012
Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension. Hypertension (Dallas, Tex. : 1979), 2013, Volume: 61, Issue:2 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Fumarates; Heart Rate; Hemodynamics; Hypertension; Kidney; Male; Rats; Renin; Renin-Angiotensin System; Telemetry; Tetrazoles; Valine; Valsartan	2013
Complement 3 activates the renal renin-angiotensin system by induction of epithelial-to-mesenchymal transition of the nephrotubulus in mice. American journal of physiology. Renal physiology, 2013, Oct-01, Volume: 305, Issue:7 Topics: Aldosterone; Amides; Angiotensin II; Animals; Antihypertensive Agents; Complement C3; Epithelial-Mesenchymal Transition; Fumarates; Hypertension; Kidney; Kruppel-Like Transcription Factors; Liver X Receptors; Male; Mice; Mice, Inbred C57BL; Nephrosclerosis; Orphan Nuclear Receptors; Renin; Renin-Angiotensin System; Transforming Growth Factor beta1; Ureteral Obstruction	2013
Renin inhibition ameliorates renal damage through prominent suppression of both angiotensin I and II in human renin angiotensinogen transgenic mice with high salt loading. Clinical and experimental nephrology, 2014, Volume: 18, Issue:4 Topics: Albuminuria; Amides; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Antihypertensive Agents; Blood Pressure; Cytoprotection; Disease Models, Animal; Disease Progression; Down-Regulation; Fumarates; Humans; Hydralazine; Hypertension; Kidney; Kidney Diseases; Mice; Mice, Transgenic; Ramipril; Renin; Renin-Angiotensin System; Sodium Chloride, Dietary; Time Factors	2014
Aliskiren attenuates steatohepatitis and increases turnover of hepatic fat in mice fed with a methionine and choline deficient diet. PloS one, 2013, Volume: 8, Issue:10 Topics: Amides; Angiotensin II; Animals; Blotting, Western; Choline; Diet; Fatty Liver; Fumarates; Immunoenzyme Techniques; Inflammation; Insulin; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Oxidative Stress; Real-Time Polymerase Chain Reaction; Renin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiobarbituric Acid Reactive Substances; Triglycerides	2013
Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors. Cardiovascular diabetology, 2013, Nov-12, Volume: 12 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Models, Animal; Down-Regulation; Fumarates; Kallikreins; Kininogens; Kinins; Mice; Mice, Knockout; Myocytes, Cardiac; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Tetrazoles; Ultrasonography; Valine; Valsartan	2013
Effects of direct Renin inhibition on myocardial fibrosis and cardiac fibroblast function. PloS one, 2013, Volume: 8, Issue:12 Topics: Amides; Angiotensin II; Animals; Antihypertensive Agents; Cardiomyopathies; Collagen; Diet; Extracellular Matrix; Fibroblasts; Fibrosis; Fumarates; Homocysteine; Mice; Myocardium; Proto-Oncogene Proteins c-akt; Renin; Renin-Angiotensin System; Signal Transduction	2013
Aliskiren limits abdominal aortic aneurysm, ventricular hypertrophy and atherosclerosis in an apolipoprotein-E-deficient mouse model. Clinical science (London, England : 1979), 2014, Volume: 127, Issue:2 Topics: Amides; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Blood Pressure; Disease Models, Animal; Fumarates; Hypertension; Hypertrophy; Mice; Mice, Inbred C57BL; Mice, Knockout	2014
Protective effects of aliskiren on atrial ionic remodeling in a canine model of rapid atrial pacing. Cardiovascular drugs and therapy, 2014, Volume: 28, Issue:2 Topics: Amides; Angiotensin II; Animals; Atrial Remodeling; Calcium Channels, L-Type; Cardiac Pacing, Artificial; Dogs; Down-Regulation; Fumarates; Gene Expression; Heart Atria; Hemodynamics; NAV1.5 Voltage-Gated Sodium Channel; Renin; Up-Regulation	2014
The restoration of kidney mitochondria function by inhibition of angiotensin-II production in rats with acute adriamycin-induced nephrotoxicity. Renal failure, 2014, Volume: 36, Issue:4 Topics: Adenosine Triphosphate; Amides; Angiotensin II; Animals; Captopril; Creatine Kinase; Doxorubicin; Fumarates; Kidney; Kidney Diseases; Male; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species; Renin; Renin-Angiotensin System	2014
Aliskiren-attenuated myocardium apoptosis via regulation of autophagy and connexin-43 in aged spontaneously hypertensive rats. Journal of cellular and molecular medicine, 2014, Volume: 18, Issue:7 Topics: Aging; Amides; Angiotensin II; Animals; Antihypertensive Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Blood Pressure; Blotting, Western; Cell Proliferation; Cells, Cultured; Connexin 43; Fluorescent Antibody Technique; Fumarates; Immunoenzyme Techniques; Male; Myocytes, Cardiac; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2014
What is the role of renin inhibition during rat septic conditions: preventive effect of aliskiren on sepsis-induced lung injury. Naunyn-Schmiedeberg's archives of pharmacology, 2014, Volume: 387, Issue:10 Topics: Amides; Angiotensin II; Animals; Fumarates; Glutathione; Lipid Peroxidation; Lung Injury; Male; Oxidative Stress; Rats; Rats, Wistar; Renin; Sepsis; Treatment Outcome	2014
Renin inhibition reduces atherosclerotic plaque neovessel formation and regresses advanced atherosclerotic plaques. Atherosclerosis, 2014, Volume: 237, Issue:2 Topics: Amides; Angiotensin II; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Blood Pressure; Carrier Proteins; Cathepsins; Chemokine CCL2; Extracellular Matrix; Fumarates; Gene Silencing; Human Umbilical Vein Endothelial Cells; Humans; Hydralazine; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Nuclear Proteins; Plaque, Atherosclerotic; Receptor, Angiotensin, Type 1; Renin; Toll-Like Receptor 2; Treatment Outcome; Vascular Cell Adhesion Molecule-1	2014
Renoprotective effect of aliskiren on renal ischemia/reperfusion injury in rats: electron microscopy and molecular study. Renal failure, 2015, Volume: 37, Issue:2 Topics: Amides; Angiotensin II; Animals; Antihypertensive Agents; Creatinine; Fumarates; Kidney; Kidney Diseases; Male; Malondialdehyde; Microscopy, Electron; Nitric Oxide; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Renin; Reperfusion Injury; Superoxide Dismutase; Treatment Outcome	2015
The Role of RAAS Inhibition by Aliskiren on Paracetamol-Induced Hepatotoxicity Model in Rats. Journal of cellular biochemistry, 2016, Volume: 117, Issue:3 Topics: Acetaminophen; Alanine Transaminase; Amides; Angiotensin II; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Fumarates; Liver; Male; Oxidants; Rats, Wistar; Renin; Renin-Angiotensin System	2016
Intrarenal renin-angiotensin system mediates fatty acid-induced ER stress in the kidney. American journal of physiology. Renal physiology, 2016, Mar-01, Volume: 310, Issue:5 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Blood Glucose; Cell Line; Cell Survival; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Fumarates; Gene Expression Regulation; Heat-Shock Proteins; Humans; Kidney Diseases; Kidney Tubules, Proximal; Male; Mice, Inbred C57BL; Palmitic Acid; Renin-Angiotensin System; RNA, Messenger; Signal Transduction; Transcription Factor CHOP; Tunicamycin; Unfolded Protein Response; Valsartan	2016
Angiotensinogen Exerts Effects Independent of Angiotensin II. Arteriosclerosis, thrombosis, and vascular biology, 2016, Volume: 36, Issue:2 Topics: Amides; Amino Acid Sequence; Angiotensin II; Angiotensinogen; Animals; Atherosclerosis; Blood Pressure; Conserved Sequence; Dependovirus; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Fumarates; Genetic Vectors; Genotype; Hepatocytes; Hypertension; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Models, Molecular; Oligonucleotides, Antisense; Phenotype; Protein Binding; Protein Interaction Domains and Motifs; Receptors, LDL; Renin; Signal Transduction; Time Factors; Transduction, Genetic; Weight Gain	2016
Concomitant inhibition of renin angiotensin system and Toll-like receptor 2 attenuates renal injury in unilateral ureteral obstructed mice. The Korean journal of internal medicine, 2016, Volume: 31, Issue:2 Topics: Amides; Angiotensin II; Animals; Disease Models, Animal; Fibrosis; Fumarates; Kidney; Male; Mice, Inbred C57BL; Mice, Knockout; Nephritis, Interstitial; Renin; Renin-Angiotensin System; RNA, Messenger; Toll-Like Receptor 2; Ureteral Obstruction	2016
Bovine ovarian cells have (pro)renin receptors and prorenin induces resumption of meiosis in vitro. Peptides, 2016, Volume: 81 Topics: Amides; Angiotensin II; Animals; Cattle; Cells, Cultured; Colforsin; Corpus Luteum; Cumulus Cells; Female; Fumarates; Granulosa Cells; Humans; Meiosis; Nucleotides, Cyclic; Oocytes; Ovarian Follicle; Ovary; Prorenin Receptor; Receptors, Cell Surface; Renin; Reproduction; RNA, Messenger; Saralasin; Theca Cells	2016
Activation of the Renin-Angiotensin System Promotes Colitis Development. Scientific reports, 2016, 06-08, Volume: 6 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Colitis; Colon; Epithelial Cells; Fumarates; Humans; Hydralazine; Inflammatory Bowel Diseases; Losartan; Mice; Mice, Transgenic; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Th17 Cells	2016
Aliskiren inhibits the renin-angiotensin system in retinal pigment epithelium cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2016, Sep-20, Volume: 92 Topics: Amides; Angiotensin II; Antihypertensive Agents; Cell Line; Fumarates; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Receptors, Cell Surface; Renin; Renin-Angiotensin System; Retinal Pigment Epithelium; Vacuolar Proton-Translocating ATPases	2016
Intracellular renin increases the inward calcium current in smooth muscle cells of mesenteric artery of SHR. Implications for hypertension and vascular remodeling. Peptides, 2016, Volume: 84 Topics: Amides; Angiotensin II; Animals; Calcium; Calcium Signaling; Disease Models, Animal; Fumarates; Humans; Hypertension; Mesenteric Arteries; Myocytes, Smooth Muscle; Rats; Renin; Vascular Remodeling; Verapamil	2016
Inhibition of Angiotensin-II Production Increases Susceptibility to Acute Ischemia/Reperfusion Arrhythmia. Medical science monitor : international medical journal of experimental and clinical research, 2016, Nov-27, Volume: 22 Topics: Amides; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Captopril; Creatine Kinase, MB Form; Fumarates; Heart; Heart Rate; Male; Myocardial Reperfusion Injury; Oxidative Stress; Rats	2016
Aliskiren increases aquaporin-2 expression and attenuates lithium-induced nephrogenic diabetes insipidus. American journal of physiology. Renal physiology, 2017, Oct-01, Volume: 313, Issue:4 Topics: Amides; Angiotensin II; Animals; Antihypertensive Agents; Aquaporin 2; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diabetes Insipidus, Nephrogenic; Drug Evaluation, Preclinical; Fumarates; Kidney Medulla; Kidney Tubules, Collecting; Lithium; Male; Mice, Inbred C57BL; Polyuria; Prorenin Receptor; Receptors, Cell Surface	2017
Brain Renin-Angiotensin System: Does It Exist? Hypertension (Dallas, Tex. : 1979), 2017, Volume: 69, Issue:6 Topics: Amides; Angiotensin II; Angiotensinogen; Animals; Blood Pressure; Blood-Brain Barrier; Brain; Desoxycorticosterone Acetate; Disease Models, Animal; Fumarates; Hypertension; Mice; Mice, Knockout; Random Allocation; Rats; Rats, Inbred SHR; Reference Values; Renin-Angiotensin System	2017
Renin inhibition improves metabolic syndrome, and reduces angiotensin II levels and oxidative stress in visceral fat tissues in fructose-fed rats. PloS one, 2017, Volume: 12, Issue:7 Topics: Adipocytes; Adipokines; Amides; Angiotensin II; Animals; Blood Glucose; Blood Pressure; Cell Size; Cholesterol; Feeding Behavior; Fructose; Fumarates; Insulin; Intra-Abdominal Fat; Male; Metabolic Syndrome; Oxidative Stress; Rats, Inbred WKY; Renin; Superoxide Dismutase; Systole; Thiobarbituric Acid Reactive Substances; Triglycerides	2017
Direct renin inhibition is not enough to prevent reactive oxygen species generation and vascular dysfunction in renovascular hypertension. European journal of pharmacology, 2018, Feb-15, Volume: 821 Topics: Amides; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta; Drug Synergism; Fumarates; Hypertension, Renovascular; Losartan; Male; Nitrites; Oxidative Stress; Rats; Reactive Oxygen Species; Relaxation; Renin	2018
Aliskiren: Preclinical evidence for the treatment of hyperproliferative skin disorders. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 104 Topics: Amides; Angiotensin II; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Cardiovascular System; Disease Models, Animal; Female; Fumarates; Inflammation; Keratinocytes; Mice; Psoriasis; Renin; Renin-Angiotensin System; Skin Diseases	2018
The renin angiotensin system (RAS) mediates bifunctional growth regulation in melanoma and is a novel target for therapeutic intervention. Oncogene, 2019, Volume: 38, Issue:13 Topics: Amides; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; DNA Methylation; Embryo, Nonmammalian; Fumarates; Humans; Imidazoles; Melanoma; Molecular Targeted Therapy; Neoplasm Metastasis; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Xenograft Model Antitumor Assays; Zebrafish	2019
[Aliskiren inhibits angiotensin II/angiotensin 1-7(Ang II/Ang1-7) signal pathway in rats with diabetic nephropathy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2018, Volume: 34, Issue:10 Topics: Amides; Angiotensin I; Angiotensin II; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fumarates; Male; Peptide Fragments; Random Allocation; Rats; Rats, Sprague-Dawley; Signal Transduction	2018
Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2020, Volume: 53, Issue:2 Topics: Amides; Angiotensin II; Animals; Apoptosis; Blotting, Western; Cardiomegaly; Disease Models, Animal; Fibrosis; Flow Cytometry; Fumarates; Isoproterenol; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; TOR Serine-Threonine Kinases	2020
Expression of Cyr61 in ApoE Scientific reports, 2021, 02-11, Volume: 11, Issue:1 Topics: Amides; Amlodipine; Angiotensin II; Animals; Antihypertensive Agents; Apolipoproteins E; Blood Pressure; Cysteine-Rich Protein 61; Fumarates; Gene Expression Regulation; Humans; Hypertension; Irbesartan; Mice; Mice, Knockout; Renal Artery; Renal Artery Obstruction	2021