Page last updated: 2024-09-03

angiotensin ii, des-phe(8)- and losartan

angiotensin ii, des-phe(8)- has been researched along with losartan in 86 studies

Compound Research Comparison

Studies (angiotensin ii, des-phe(8)-)	Trials (angiotensin ii, des-phe(8)-)	Recent Studies (post-2010) (angiotensin ii, des-phe(8)-)	Studies (losartan)	Trials (losartan)	Recent Studies (post-2010) (losartan)
1,533	21	995	7,231	1,245	2,118

Protein Interaction Comparison

Protein	Taxonomy	losartan (IC50)
Bile salt export pump	Homo sapiens (human)	9.01
Cytochrome P450 2C9	Homo sapiens (human)	2.882
Angiotensin-converting enzyme	Homo sapiens (human)	0.019
Atrial natriuretic peptide receptor 3	Homo sapiens (human)	0.0018
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	0.019
Type-1A angiotensin II receptor	Rattus norvegicus (Norway rat)	0.0247
Type-1B angiotensin II receptor	Rattus norvegicus (Norway rat)	0.0234
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	0.0032
Type-1 angiotensin II receptor	Homo sapiens (human)	0.047
Type-1 angiotensin II receptor	Oryctolagus cuniculus (rabbit)	0.025
Type-2 angiotensin II receptor	Rattus norvegicus (Norway rat)	0.0118
Type-2 angiotensin II receptor	Homo sapiens (human)	0.019
Platelet glycoprotein VI	Homo sapiens (human)	4
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	1.1481
Type-1 angiotensin II receptor	Cavia porcellus (domestic guinea pig)	0.018
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	0.2884

Research

Studies (86)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	21 (24.42)	18.2507
2000's	32 (37.21)	29.6817
2010's	29 (33.72)	24.3611
2020's	4 (4.65)	2.80

Authors

Authors	Studies
Andries, M; Denef, C; Robberecht, W	1
Diz, DI; Ferrario, CM; Jaiswal, N; Khosla, MC; Tallant, EA	1
Dean, RH; Ferrario, CM; Fuller, SB; Nakamoto, H; Robaczewski, DL; Winicov, E	1
Smith, RD	1
Ahima, RS; Kadowitz, PJ; Khosla, MC; Minkes, RK; Osei, SY; Weaver, JP	1
Carr, RD; Henderson, IW; Mahon, JM; Nicol, AK	1
Garcia, NH; Garvin, JL	1
Campagnole-Santos, MJ; Fontes, MA; Guertzenstein, PG; Khosla, MC; Santos, RA; Silva, LC	1
Adler-Graschinsky, E; Enero, MA; Gironacci, MM; Peña, C	1
Cooney, AS; Fitzsimons, JT	1
Campagnole-Santos, MJ; Fontes, MA; Khosla, MC; Lima, DX; Oliveira, RC; Santos, RA	1
Higson, JT; Tallant, EA	1
Campagnole-Santos, MJ; Fontes, MA; Khosla, MC; Lopes, OU; Martins Pinge, MC; Naves, V; Santos, RA	1
Forster, C; le Tran, Y	1
Chappell, MC; Ferrario, CM; Iyer, SN	1
Averill, DB; Chappell, MC; Diz, DI; Ferrario, CM; Iyer, SN	1
Fechter, K; Heyne, N; Khosla, MC; Richter, K; Vallon, V	1
Chappell, MC; Ferrario, CM; Ganten, D; Iyer, SN; Yamada, K	1
Baracho, NC; Khosla, MC; Santos, RA; Simões-e-Silva, AC	1
Brosnihan, KB; Chappell, MC; Ferrario, CM; Fukuhara, M; Iyer, SN; Yamada, K	1
Coba, MP; Gironacci, MM; Peña, C	1
Dixon, B; Rowe, BP	1
Cervenka, L; Heller, J; Horácek, V; Kramer, HJ; Malý, J	1
Chappell, MC; Diz, DI; Ferrario, CM; Iyer, SN; Yamada, K	1
Andrade, SP; Campagnole-Santos, MJ; Santos, RA	1
Coviello, A; Jerez, S; Peral de Bruno, M; Santos, JC	1
Min, L; Sim, MK; Xu, XG	1
Andrade, SP; Machado, RD; Santos, RA	1
DiBona, GF; Jones, SY	1
Bica, RB; Caruso-Neves, C; Correa, JS; Lara, LS; Lopes, AG; Marques-Fernandes, MF; Sena, SL	1
Buczko, W; Chabielska, E; Kucharewicz, I; Matys, T; Pawlak, D; Rólkowski, R	1
Buczko, W; Kucharewicz, I; Matys, T; Pawlak, D; Pawlak, R	1
Dobrucki, LW; Heitsch, H; Louka, FR; Malinski, T; Wiemer, G	1
Bild, W; Boisteanu, CP; Haulica, I; Ionita, T; Mihaila, CN; Neagu, B	1
Collister, JP; Hendel, MD	1
Averill, DB; Brosnihan, KB; Ferrario, CM; Gallagher, PE; Ishiyama, Y; Tallant, EA	1
Carey, RM	1
Abi-Abib, R; Cardozo, FP; Caruso-Neves, C; De Souza, AM; Fernandes, MS; Fossari, RN; Lopes, AG; Miguel, NC; Pizzino, CP; Santos, DP	1
Ecarnot-Laubriet, A; Oudot, A; Rochette, L; Vergely, C	1
Averill, DB; Brosnihan, KB; Chappell, MC; Diz, DI; Ferrario, CM; Gallagher, PE; Jessup, J; Tallant, EA	1
Alenina, N; Almeida, AP; Bader, M; Castro, CH; Ferreira, AJ; Santos, RA	1
Chappell, MC; Ferrario, CM; Gallagher, PE; Tallant, EA	1
Ann Tallant, E; Averill, DB; Brosnihan, KB; Chappell, MC; Ferrario, CM; Gallagher, PE; Jessup, J; Smith, RD	1
Peña, C; Pereyra-Alfonso, S; Rodríguez de Lores Arnaiz, G	1
Campagnole-Santos, MJ; Ferreira, PM; Souza Dos Santos, RA	1
Dominici, FP; Giani, JF; Gironacci, MM; Muñoz, MC; Peña, C; Turyn, D	1
Gironacci, MM; Peña, C; Polizio, AH; Tomaro, ML	1
Anton, L; Brosnihan, KB; Merrill, DC; Neves, LA	1
Campbell, WB; Cui, L; Gauthier, KM; Nithipatikom, K; Zhang, DX	1
Ferrario, CM; Gallagher, PE; Tallant, EA	1
Clarke, D; Medow, MS; Ocon, AJ; Stewart, JM; Taneja, I	1
Anton, L; Brosnihan, KB; Corthorn, J; Diz, DI; Gallagher, PE; Gruver, C; Merrill, DC; Moorefield, C; Neves, LA; Stovall, K; Valdes, G	1
Alzamora, AC; Campagnole-Santos, MJ; Cangussu, LM; de Castro, UG; do Pilar Machado, R; dos Santos, RA; Ferreira, PM; Silva, ME	1
Chappell, MC; Diz, DI; Gwathmey, TM; Pendergrass, KD; Reid, SD; Rose, JC	1
Gao, J; Gao, XY; Han, Y; Shi, Z; Yuan, N; Zhou, LM; Zhu, GQ	1
Chudakov, DM; Guo, F; Kasparov, S; Lane, S; Liu, B; Paton, JF; Souslova, EA; Tang, F	1
Burns, KD; Dilauro, M; Genest, D; Robertson, SJ; Zimpelmann, J	1
Durand, MJ; Lombard, JH; Raffai, G; Weinberg, BD	1
Cassis, LA; Daugherty, A; Gurley, SB; Howatt, DA; Lu, H; Thatcher, SE; Zhang, X	1
Cao, K; Chen, XM; Huang, HJ; Huang, J; Lu, XZ; Qin, XY; Yang, XH; Yong, YH; Zheng, HJ; Zong, WN	1
Bos, AP; Florquin, S; Kamilic, J; Lutter, R; Moll, GN; Specht, PA; van der Loos, CM; van Goor, H; van Woensel, JB; Wösten-van Asperen, RM	1
Alenina, N; Bader, M; de Oliveira, ML; Dos Santos, RA; Fontes, WR; Lazaroni, TL; Moraes, MF; Pereira, GS; Raslan, AC	1
Boustany-Kari, CM; Cassis, LA; Gupte, M; Karounos, M; Shoemaker, R; Thatcher, SE; Yiannikouris, F; Zhang, X	1
Huang, Y; Lu, L; Ni, J; Wang, J; Wang, Z; Xue, H; Yao, T; Yu, C; Yuan, P; Zhou, L	1
Akhtar, S; Benter, IF; Dhaunsi, GS; Makki, BM; Qabazard, BA; Yousif, MH	1
Chen, WW; Han, Y; Li, P; Sun, HJ; Xiong, XQ	1
Bader, M; Castro Perez, A; Duarte, ID; Lima, Mde P; Pacheco, CM; Pacheco, Dda F; Pesquero, JL; Souza, Ade L	1
Almeida, JF; Alves, GM; Castro, CH; Colugnati, DB; Ferreira, AJ; Macedo, LM; Mendes, EP; Porto, JE; Santos, RA; Sobrinho, DB; Souza, ÁP; Vêncio, EF	1
Bader, M; Barroso, LC; Coelho, FM; Costa, VV; Oliveira, ML; Queiroz-Junior, CM; Santos, RA; Silva, AC; Silva, TA; Silveira, KD; Sousa, LF; Teixeira, MM; Vieira, AT	1
Arantes, RM; Bader, M; Barroso, LC; Cisalpino, D; Dos Santos, RA; Lima, CX; Silveira, KD; Simões-E-Silva, AC; Teixeira, MM; Vieira, AT	1
Chen, Q; Huang, Y; Liu, L; Pan, C; Qiu, H; Yang, Y	1
Ding, W; Gu, Y; Xu, C; Zhang, M	1
Chen, X; Dong, B; Hao, QQ; Li, SY; Wang, N; Wang, XY; Yu, QT; Zhang, YH; Zhu, L	1
Amorim, MJ; Bento-Leite, A; Brás-Silva, C; Castro-Chaves, P; Cerqueira, R; Leite-Moreira, AF; Mendes-Ferreira, P; Mendonça, L; Pinho, P	1
Dong, M; Guan, J; Meng, X; Niu, R; Sun, Y; Yang, J; Yang, X; Zhang, C; Zhang, Y	1
Han, Y; Li, P; Sun, HJ; Zhang, F	1
Bastos, CP; Lazaroni, TL; Moraes, MF; Pereira, GS; Santos, RS	1
Brzozowski, T; Konturek, SJ; Korbut, R; Kwiecien, S; Madej, J; Olszanecki, R; Pajdo, R; Pawlik, MW; Ptak-Belowska, A; Suski, M; Targosz, A	1
Arnold, MR; Forte, BL; Hay, M; Largent-Milnes, TM; Slosky, LM; Staatz, WD; Vanderah, TW; Zhang, H	1
Alves, PH; Castro, CH; Colugnati, DB; Macedo, LM; Mendes, EP; Nunes, AD; Pedrino, GR; Santos, RA; Souza, AP	1
Abuohashish, HM; Ahmed, MM; Al-Rejaie, SS; Khattab, MM; Sabry, D	1
Healy, V; Johns, EJ; O'Neill, J	1
Campos, GV; Chianca, D; De Menezes, RCA; De Souza, AMA; Ji, H; Linares, A; Sandberg, K; Speth, RC	1
Gao, X; Ge, X; Jin, F; Li, S; Li, Y; Mao, N; Wei, Z; Xu, H; Yang, F; Yang, Y; Zhang, M; Zhang, Y	1
Costa-Ferreira, W; Crestani, CC; Marchi-Coelho, C; Moreno-Santos, B	1
Carletti, R; Castoldi, G; di Gioia, CRT; Ippolito, S; Pelucchi, S; Stella, A; Zatti, G; Zerbini, G	1

Reviews

1 review(s) available for angiotensin ii, des-phe(8)- and losartan

Article	Year
Angiotensin-(1-7): an update. Regulatory peptides, 2000, Jul-28, Volume: 91, Issue:1-3 Topics: Angiotensin I; Angiotensin II; Animals; Blood Vessels; Central Nervous System; Humans; Kidney; Losartan; Models, Biological; Myocardium; Peptide Fragments; Peptidyl-Dipeptidase A; Protein Binding; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Signal Transduction; Vasoconstriction	2000

Article

Year

Angiotensin-(1-7): an update.

Regulatory peptides, 2000, Jul-28, Volume: 91, Issue:1-3

Topics: Angiotensin I; Angiotensin II; Animals; Blood Vessels; Central Nervous System; Humans; Kidney; Losartan; Models, Biological; Myocardium; Peptide Fragments; Peptidyl-Dipeptidase A; Protein Binding; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Signal Transduction; Vasoconstriction

2000

Other Studies

85 other study(ies) available for angiotensin ii, des-phe(8)- and losartan

Article	Year
Angiotensin II is retained in gonadotrophs of pituitary cell aggregates cultured in serum-free medium but does not mimic the effects of exogenous angiotensins and luteinizing-hormone-releasing hormone on growth hormone release. Neuroendocrinology, 1992, Volume: 56, Issue:4 Topics: Angiotensin II; Angiotensins; Animals; Biphenyl Compounds; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media, Serum-Free; Female; Gonadotropin-Releasing Hormone; Growth Hormone; Imidazoles; Immunohistochemistry; Losartan; Pituitary Gland, Anterior; Radioimmunoassay; Rats; Rats, Wistar; Saralasin; Tetrazoles	1992
Characterization of angiotensin receptors mediating prostaglandin synthesis in C6 glioma cells. The American journal of physiology, 1991, Volume: 260, Issue:5 Pt 2 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Glioma; Imidazoles; Losartan; Oligopeptides; Peptide Fragments; Prostaglandins; Receptors, Angiotensin; Tetrazoles; Tumor Cells, Cultured	1991
Angiotensin-(1-7) and nitric oxide interaction in renovascular hypertension. Hypertension (Dallas, Tex. : 1979), 1995, Volume: 25, Issue:4 Pt 2 Topics: Amino Acid Oxidoreductases; Angiotensin I; Angiotensin II; Angiotensins; Animals; Arginine; Biphenyl Compounds; Dogs; Hemodynamics; Hypertension, Renovascular; Imidazoles; Lisinopril; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Peptidyl-Dipeptidase A; Tetrazoles	1995
Identification of atypical (non-AT1, non-AT2) angiotensin binding sites with high affinity for angiotensin I on IEC-18 rat intestinal epithelial cells. FEBS letters, 1995, Oct-16, Volume: 373, Issue:3 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Epithelium; Imidazoles; Intestinal Mucosa; Intestine, Small; Losartan; Oligopeptides; Peptide Fragments; Pyridines; Rats; Receptors, Angiotensin; Tetrazoles	1995
Differential responses to angiotensin-(1-7) in the feline mesenteric and hindquarters vascular beds. European journal of pharmacology, 1993, Mar-30, Volume: 234, Issue:1 Topics: Amino Acid Oxidoreductases; Angiotensin I; Angiotensin II; Angiotensin III; Animals; Arginine; Biphenyl Compounds; Cats; Hindlimb; Imidazoles; Losartan; Meclofenamic Acid; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Perfusion; Tetrazoles; Vascular Resistance; Vasoconstriction	1993
Angiotensin(1-7) is an antagonist at the type 1 angiotensin II receptor. Journal of hypertension, 1994, Volume: 12, Issue:12 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Imidazoles; In Vitro Techniques; Losartan; Male; Peptide Fragments; Rabbits; Rats; Rats, Sprague-Dawley; Tetrazoles	1994
Angiotensin 1-7 has a biphasic effect on fluid absorption in the proximal straight tubule. Journal of the American Society of Nephrology : JASN, 1994, Volume: 5, Issue:4 Topics: Adsorption; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bicarbonates; Biphenyl Compounds; Imidazoles; In Vitro Techniques; Ion Transport; Kidney Tubules, Proximal; Kinetics; Losartan; Male; Peptide Fragments; Perfusion; Permeability; Pyridines; Rats; Rats, Sprague-Dawley; Tetrazoles	1994
Evidence that angiotensin-(1-7) plays a role in the central control of blood pressure at the ventro-lateral medulla acting through specific receptors. Brain research, 1994, Nov-28, Volume: 665, Issue:1 Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Imidazoles; Losartan; Male; Medulla Oblongata; Oligopeptides; Peptide Fragments; Rats; Rats, Wistar; Tetrazoles	1994
Effects of angiotensin II and angiotensin-(1-7) on the release of [3H]norepinephrine from rat atria. Hypertension (Dallas, Tex. : 1979), 1994, Volume: 24, Issue:4 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Drug Interactions; Electric Stimulation; Female; Heart; Heart Atria; Imidazoles; Losartan; Myocardium; Norepinephrine; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Saralasin; Tetrazoles	1994
The effect of the putative AT2 agonist, p-aminophenylalanine6 angiotensin II, on thirst and sodium appetite in rats. Experimental physiology, 1993, Volume: 78, Issue:6 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Appetite; Biphenyl Compounds; Drinking; Imidazoles; Injections, Intraventricular; Losartan; Male; Oligopeptides; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Sodium Chloride, Dietary; Tetrazoles; Thirst	1993
Pressor action of angiotensin I at the ventrolateral medulla: effect of selective angiotensin blockade. Immunopharmacology, 1996, Volume: 33, Issue:1-3 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Imidazoles; Losartan; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Ramipril; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles	1996
Angiotensin II activates distinct signal transduction pathways in astrocytes isolated from neonatal rat brain. Glia, 1997, Volume: 19, Issue:4 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Astrocytes; Biphenyl Compounds; Bradykinin; Brain; Cells, Cultured; Cerebellum; Cerebral Cortex; Epoprostenol; Humans; Hypothalamus; Imidazoles; Losartan; Medulla Oblongata; Peptide Fragments; Phosphatidylinositol Diacylglycerol-Lyase; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetrazoles; Type C Phospholipases	1997
Cardiovascular effects produced by microinjection of angiotensins and angiotensin antagonists into the ventrolateral medulla of freely moving rats. Brain research, 1997, Mar-07, Volume: 750, Issue:1-2 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Heart Rate; Imidazoles; Losartan; Male; Medulla Oblongata; Microinjections; Oligopeptides; Peptide Fragments; Rats; Rats, Wistar; Tetrazoles; Time Factors	1997
Angiotensin-(1-7) and the rat aorta: modulation by the endothelium. Journal of cardiovascular pharmacology, 1997, Volume: 30, Issue:5 Topics: Angiotensin I; Angiotensin II; Angiotensin III; Animals; Antihypertensive Agents; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin	1997
Angiotensin-(1-7) contributes to the antihypertensive effects of blockade of the renin-angiotensin system. Hypertension (Dallas, Tex. : 1979), 1998, Volume: 31, Issue:1 Pt 2 Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Dipeptides; Heart Rate; Hypertension; Kinetics; Lisinopril; Losartan; Male; Neprilysin; Organophosphonates; Peptide Fragments; Peptides, Cyclic; Phenylalanine; Protease Inhibitors; Rats; Rats, Inbred SHR; Renin-Angiotensin System	1998
Vasodepressor actions of angiotensin-(1-7) unmasked during combined treatment with lisinopril and losartan. Hypertension (Dallas, Tex. : 1979), 1998, Volume: 31, Issue:2 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antibodies, Monoclonal; Antihypertensive Agents; Blood Pressure; Heart Rate; Imidazoles; Immunoglobulin G; Lisinopril; Losartan; Male; Mice; Mice, Inbred BALB C; Peptide Fragments; Pyridines; Rats; Rats, Inbred SHR; Vasodilation	1998
[7-D-ALA]-angiotensin 1-7 blocks renal actions of angiotensin 1-7 in the anesthetized rat. Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:1 Topics: Anesthesia; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Kidney; Kidney Function Tests; Kidney Tubules, Proximal; Losartan; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Renal Circulation	1998
Converting enzyme determines plasma clearance of angiotensin-(1-7). Hypertension (Dallas, Tex. : 1979), 1998, Volume: 32, Issue:3 Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Blood Pressure; Chromatography, High Pressure Liquid; Drug Combinations; Half-Life; Lisinopril; Losartan; Male; Metabolic Clearance Rate; Peptide Fragments; Radioimmunoassay; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Species Specificity	1998
Effect of selective angiotensin antagonists on the antidiuresis produced by angiotensin-(1-7) in water-loaded rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1998, Volume: 31, Issue:9 Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Diuresis; Drinking; Kidney; Losartan; Male; Peptide Fragments; Rats; Rats, Wistar; Receptors, Angiotensin; Renal Agents	1998
Differential response of angiotensin peptides in the urine of hypertensive animals. Regulatory peptides, 1999, Mar-17, Volume: 80, Issue:1-2 Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Pressure; Body Weight; Drinking; Electrolytes; Hemodynamics; Hypertension; Lisinopril; Losartan; Male; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley	1999
Angiotensin-(1-7) binds at the type 1 angiotensin II receptors in rat renal cortex. Regulatory peptides, 1999, Oct-22, Volume: 84, Issue:1-3 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Imidazoles; Iodine Radioisotopes; Kidney Cortex; Losartan; Male; Peptide Fragments; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Angiotensin	1999
Angiotensin III depressor action in the conscious rabbit is blocked by losartan but not PD 123319. Hypertension (Dallas, Tex. : 1979), 2000, Volume: 35, Issue:1 Pt 1 Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Imidazoles; Losartan; Male; Peptide Fragments; Pyridines; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin	2000
Effect of intrarenal infusion of angiotensin-(1-7) in the dog. Kidney & blood pressure research, 2000, Volume: 23, Issue:2 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Diuresis; Dogs; Female; Glomerular Filtration Rate; Imidazoles; Infusions, Intra-Arterial; Kidney; Losartan; Male; Peptide Fragments; Receptors, Angiotensin; Renal Artery; Renal Circulation; Tetrazoles; Urodynamics; Vasodilator Agents	2000
Evidence that prostaglandins mediate the antihypertensive actions of angiotensin-(1-7) during chronic blockade of the renin-angiotensin system. Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:1 Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Cyclooxygenase Inhibitors; Heart Rate; Lisinopril; Losartan; Male; Peptide Fragments; Prostaglandins; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Renin-Angiotensin System	2000
Angiotensin-(1-7) increases osmotic water permeability in isolated toad skin. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2000, Volume: 33, Issue:9 Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Anura; Humans; Losartan; Oxytocin; Peptide Fragments; Permeability; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Skin; Skin Absorption; Vasoconstrictor Agents; Vasotocin; Water	2000
Effects of des-aspartate-angiotensin I on angiotensin II-induced incorporation of phenylalanine and thymidine in cultured rat cardiomyocytes and aortic smooth muscle cells. Regulatory peptides, 2000, Nov-24, Volume: 95, Issue:1-3 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Aorta, Thoracic; Cells, Cultured; DNA; Imidazoles; Indomethacin; Losartan; Muscle, Smooth, Vascular; Myocardium; Peptide Fragments; Phenylalanine; Protein Biosynthesis; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Thymidine	2000
Mechanisms of angiotensin-(1-7)-induced inhibition of angiogenesis. American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:4 Topics: Analysis of Variance; Angiogenesis Inhibitors; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Imidazoles; Losartan; Male; Mice; Neovascularization, Pathologic; Neovascularization, Physiologic; Peptide Fragments; Prostheses and Implants; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2	2001
Sodium intake influences hemodynamic and neural responses to angiotensin receptor blockade in rostral ventrolateral medulla. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:4 Topics: Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Baroreflex; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Heart Failure; Heart Rate; Hemodynamics; Kidney; Losartan; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Sodium, Dietary; Sympathetic Nervous System; Tetrazoles	2001
Angiotensin-(1-7) reverts the stimulatory effect of angiotensin II on the proximal tubule Na(+)-ATPase activity via a A779-sensitive receptor. Regulatory peptides, 2002, Jan-15, Volume: 103, Issue:1 Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Cell Membrane; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Kidney Tubules, Proximal; Losartan; Peptide Fragments; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Saralasin; Sodium-Potassium-Exchanging ATPase; Swine	2002
The antithrombotic effect of angiotensin-(1-7) closely resembles that of losartan. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2000, Volume: 1, Issue:3 Topics: Angiotensin I; Animals; Antihypertensive Agents; Blood Pressure; Collagen; Fibrinolytic Agents; Hemostasis; Losartan; Male; Peptide Fragments; Platelet Adhesiveness; Rats; Rats, Inbred SHR; Rats, Wistar; Venous Thrombosis	2000
Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7). Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:5 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Epoprostenol; Fibrinolytic Agents; Hypertension, Renal; Imidazoles; Infusions, Intravenous; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Tetrazoles; Venous Thrombosis	2002
AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium. Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:6 Topics: Angiotensin I; Animals; Binding, Competitive; Cattle; Cells, Cultured; Cricetinae; Electrochemistry; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Losartan; Molecular Mimicry; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peptide Fragments; Pyridines; Radioligand Assay; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Substrate Specificity; Superoxides; Tetrazoles	2002
Biphasic effects of angiotensin (1-7) and its interactions with angiotensin II in rat aorta. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2003, Volume: 4, Issue:2 Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Drug Interactions; Imidazoles; In Vitro Techniques; Losartan; Male; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Vasoconstriction; Vasoconstrictor Agents; Vasodilation	2003
The role of Ang (1-7) in mediating the chronic hypotensive effects of losartan in normal rats. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2003, Volume: 4, Issue:3 Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Chronic Disease; Drug Interactions; Heart Rate; Hypotension; Losartan; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley	2003
Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:5 Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Carboxypeptidases; Cardiomyopathy, Hypertrophic; Coronary Vessels; Disease Models, Animal; Enzyme Induction; Imidazoles; Ligation; Losartan; Male; Myocardial Infarction; Myocardium; Olmesartan Medoxomil; Peptide Fragments; Peptidyl-Dipeptidase A; Pyridines; Rats; Rats, Inbred Lew; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Tetrazoles; Ventricular Remodeling	2004
Angiotensin type-1 receptor blockade increases ACE 2 expression in the heart. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:5 Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Carboxypeptidases; Down-Regulation; Enzyme Induction; Heart; Humans; Imidazoles; Losartan; Mice; Myocardial Infarction; Myocardium; Olmesartan Medoxomil; Peptide Fragments; Peptidyl-Dipeptidase A; Pyridines; Rats; Rats, Inbred Lew; Tetrazoles	2004
Angiotensin II and angiotensin-(1-7) inhibit the inner cortex Na+ -ATPase activity through AT2 receptor. Regulatory peptides, 2004, Aug-15, Volume: 120, Issue:1-3 Topics: Adjuvants, Immunologic; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Antihypertensive Agents; Cholera Toxin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Imidazoles; Kidney Cortex; Losartan; Peptide Fragments; Pertussis Toxin; Pyridines; Receptor, Angiotensin, Type 2; Sodium-Potassium-Exchanging ATPase; Swine; Vasoconstrictor Agents	2004
Pharmacological concentration of angiotensin-(1-7) activates NADPH oxidase after ischemia-reperfusion in rat heart through AT1 receptor stimulation. Regulatory peptides, 2005, Apr-15, Volume: 127, Issue:1-3 Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Enzyme Activation; Heart; In Vitro Techniques; Losartan; Male; Myocardial Ischemia; Myocardium; NADPH Oxidases; Peptide Fragments; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Reperfusion	2005
Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation, 2005, May-24, Volume: 111, Issue:20 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Carboxypeptidases; Gene Expression Regulation; Lisinopril; Losartan; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Lew; RNA, Messenger	2005
Evidence for a functional interaction of the angiotensin-(1-7) receptor Mas with AT1 and AT2 receptors in the mouse heart. Hypertension (Dallas, Tex. : 1979), 2005, Volume: 46, Issue:4 Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Drug Synergism; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; NG-Nitroarginine Methyl Ester; Peptide Fragments; Perfusion; Pressure; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Vasoconstrictor Agents	2005
Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes. American journal of physiology. Cell physiology, 2006, Volume: 290, Issue:2 Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Antihypertensive Agents; Astrocytes; Carboxypeptidases; Cells, Cultured; Cerebellum; Female; Gene Expression Regulation; Imidazoles; Losartan; Medulla Oblongata; Peptide Fragments; Peptidyl-Dipeptidase A; Pregnancy; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetrazoles; Valine; Valsartan; Vasoconstrictor Agents	2006
Effects of renin-angiotensin system blockade on renal angiotensin-(1-7) forming enzymes and receptors. Kidney international, 2005, Volume: 68, Issue:5 Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Carboxypeptidases; Gene Expression Regulation, Enzymologic; Hypertension, Renal; Kidney; Lisinopril; Losartan; Male; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Lew; Receptors, Angiotensin; Renin-Angiotensin System	2005
Phosphoinositide hydrolysis increase by angiotensin-(1--7) in neonatal rat brain. Regulatory peptides, 2007, May-03, Volume: 140, Issue:3 Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Antihypertensive Agents; Cerebral Cortex; Female; Hydrolysis; Losartan; Male; Peptide Fragments; Phosphatidylinositols; Rats; Rats, Inbred BB; Signal Transduction	2007
Angiotensin-(3-7) pressor effect at the rostral ventrolateral medulla. Regulatory peptides, 2007, Jun-07, Volume: 141, Issue:1-3 Topics: Anesthetics, Intravenous; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Losartan; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Pulsatile Flow; Rats; Rats, Wistar; Urethane	2007
Angiotensin-(1 7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:2 Topics: Androstadienes; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Dose-Response Relationship, Drug; Insulin; Insulin Receptor Substrate Proteins; Janus Kinase 2; Losartan; Male; Myocardium; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Signal Transduction; Tyrphostins; Wortmannin	2007
Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production. Pharmacological research, 2007, Volume: 56, Issue:1 Topics: Acetophenones; Allopurinol; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Drug Antagonism; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Male; NADH, NADPH Oxidoreductases; NG-Nitroarginine Methyl Ester; Onium Compounds; Peptide Fragments; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Superoxides	2007
Angiotensin-(1-7) inhibits in vitro endothelial cell tube formation in human umbilical vein endothelial cells through the AT(1-7) receptor. Endocrine, 2007, Volume: 32, Issue:2 Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antihypertensive Agents; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Imidazoles; Losartan; Neovascularization, Physiologic; Peptide Fragments; Pyridines; Receptors, Angiotensin; Umbilical Veins; Vasoconstrictor Agents	2007
Angiotensin II relaxations of bovine adrenal cortical arteries: role of angiotensin II metabolites and endothelial nitric oxide. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:1 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenal Cortex; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin III; Animals; Arteries; Cattle; Endothelium, Vascular; Imidazoles; Losartan; Nitric Oxide; Peptide Fragments; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vasoconstriction; Vasoconstrictor Agents; Vasodilation	2008
Regulation of ACE2 in cardiac myocytes and fibroblasts. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:6 Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Animals, Newborn; Atrial Natriuretic Factor; Butadienes; Cells, Cultured; Endothelin-1; Fibroblasts; Flavonoids; Gene Expression Regulation, Enzymologic; Heart Ventricles; Losartan; Mitogen-Activated Protein Kinase 1; Myocytes, Cardiac; Nitriles; Peptide Fragments; Peptidyl-Dipeptidase A; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction	2008
Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome. Hypertension (Dallas, Tex. : 1979), 2009, Volume: 53, Issue:5 Topics: Adolescent; Adult; Angiotensin I; Angiotensin-Converting Enzyme 2; Female; Humans; Losartan; Male; Nitroarginine; Peptide Fragments; Peptidyl-Dipeptidase A; Postural Orthostatic Tachycardia Syndrome; Skin; Vasodilation	2009
The uterine placental bed Renin-Angiotensin system in normal and preeclamptic pregnancy. Endocrinology, 2009, Volume: 150, Issue:9 Topics: Alanine; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Down-Regulation; Female; Gene Expression; Humans; Imidazoles; Losartan; Peptide Fragments; Peptidyl-Dipeptidase A; Placenta; Pre-Eclampsia; Pregnancy; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Stereoisomerism; Uterus	2009
Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia. Peptides, 2009, Volume: 30, Issue:10 Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Bradycardia; Heart Rate; Hypertension; Losartan; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Rats; Rats, Inbred F344	2009
Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 55, Issue:1 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Animals; Blotting, Western; Enzyme Inhibitors; Female; Imidazoles; Kidney Cortex; Leucine; Losartan; Peptide Fragments; Peptidyl-Dipeptidase A; Pyridines; Reactive Oxygen Species; Receptors, Angiotensin; Sheep; Time Factors	2010
Angiotensin-(1-7) and angiotension II in the rostral ventrolateral medulla modulate the cardiac sympathetic afferent reflex and sympathetic activity in rats. Pflugers Archiv : European journal of physiology, 2010, Volume: 459, Issue:5 Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Losartan; Male; Medulla Oblongata; Peptide Fragments; Rats; Rats, Sprague-Dawley	2010
Astroglia are a possible cellular substrate of angiotensin(1-7) effects in the rostral ventrolateral medulla. Cardiovascular research, 2010, Aug-01, Volume: 87, Issue:3 Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Astrocytes; Biosensing Techniques; Blood Pressure; Calcium Signaling; Catecholamines; Disease Models, Animal; Genes, Reporter; Hypertension; Losartan; Medulla Oblongata; Membrane Potentials; Microscopy, Confocal; Patch-Clamp Techniques; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Wistar; Tissue Culture Techniques	2010
Effect of ACE2 and angiotensin-(1-7) in a mouse model of early chronic kidney disease. American journal of physiology. Renal physiology, 2010, Volume: 298, Issue:6 Topics: Albuminuria; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Chronic Disease; Disease Models, Animal; Glomerular Filtration Rate; Hematocrit; Imidazoles; Infusion Pumps; Injections, Subcutaneous; Inulin; Kidney; Kidney Diseases; Leucine; Losartan; Male; Mice; Nephrectomy; Organ Size; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Time Factors	2010
Angiotensin-(1-7) and low-dose angiotensin II infusion reverse salt-induced endothelial dysfunction via different mechanisms in rat middle cerebral arteries. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:4 Topics: Acetylcholine; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cerebral Arterial Diseases; Cerebral Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Imidazoles; Infusions, Intravenous; Losartan; Male; Nitroprusside; Peptide Fragments; Pyridines; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Superoxides; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents	2010
Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice. Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:4 Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Atherosclerosis; Bone Marrow Cells; Bone Marrow Transplantation; Cell Adhesion; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Cytokines; Dietary Fats; Disease Models, Animal; Endothelial Cells; Humans; Inflammation Mediators; Losartan; Macrophages; Male; Mice; Mice, Knockout; Monocytes; Peptide Fragments; Peptidyl-Dipeptidase A; Receptors, LDL	2011
Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure. Acta pharmacologica Sinica, 2011, Volume: 32, Issue:11 Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Antibiotics, Antineoplastic; Benzimidazoles; Benzoates; Doxorubicin; Gene Expression Regulation; Heart; Heart Failure; Losartan; Male; Myocardium; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Telmisartan	2011
Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist. The Journal of pathology, 2011, Volume: 225, Issue:4 Topics: Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Intubation, Intratracheal; Lipopolysaccharides; Losartan; Lung; Macrophages, Alveolar; Male; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome	2011
Angiotensin-(1-7)/Mas axis integrity is required for the expression of object recognition memory. Neurobiology of learning and memory, 2012, Volume: 97, Issue:1 Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Hippocampus; Imidazoles; Losartan; Mice; Mice, Knockout; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Receptors, Angiotensin; Receptors, G-Protein-Coupled; Recognition, Psychology	2012
Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice. Arteriosclerosis, thrombosis, and vascular biology, 2012, Volume: 32, Issue:6 Topics: 3T3-L1 Cells; Adipocytes; Adiposity; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Blood Pressure; Diet, High-Fat; Disease Models, Animal; Estrogens; Female; Gene Expression Regulation, Enzymologic; Hypertension; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Ovariectomy; Peptide Fragments; Peptidyl-Dipeptidase A; Progesterone; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptors, G-Protein-Coupled; Risk Factors; RNA, Messenger; Sex Factors; Testosterone; Time Factors; Weight Gain	2012
Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells. Regulatory peptides, 2012, Aug-20, Volume: 177, Issue:1-3 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blotting, Western; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Interactions; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Glomerular Mesangium; Imidazoles; Losartan; MAP Kinase Signaling System; Mesangial Cells; Microscopy, Confocal; Peptide Fragments; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Rats; Real-Time Polymerase Chain Reaction; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, G-Protein-Coupled; Transforming Growth Factor beta1	2012
Characterization of Angiotensin-(1-7) effects on the cardiovascular system in an experimental model of type-1 diabetes. Pharmacological research, 2012, Volume: 66, Issue:3 Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Captopril; Cardiovascular System; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Endothelin-1; Hyperglycemia; Kidney; Losartan; Male; NADPH Oxidases; Peptide Fragments; Peptides; Peptidyl-Dipeptidase A; Prostaglandins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Reperfusion Injury	2012
Angiotensin II and angiotensin-(1-7) in paraventricular nucleus modulate cardiac sympathetic afferent reflex in renovascular hypertensive rats. PloS one, 2012, Volume: 7, Issue:12 Topics: Afferent Pathways; Angiotensin I; Angiotensin II; Animals; Blood Pressure; Body Weight; Heart; Heart Rate; Hypertension, Renovascular; Kidney; Losartan; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Reflex; Sympathetic Nervous System; Systole	2012
Antinociceptive response in transgenic mice expressing rat tonin. European journal of pharmacology, 2013, Aug-05, Volume: 713, Issue:1-3 Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Behavior, Animal; Disease Models, Animal; Losartan; Male; Mice; Mice, Transgenic; Nociception; Nociceptive Pain; Pain Measurement; Peptide Fragments; Rats; Receptors, G-Protein-Coupled; Tissue Kallikreins	2013
Angiotensin II type 1 receptor blockade restores angiotensin-(1-7)-induced coronary vasodilation in hypertrophic rat hearts. Clinical science (London, England : 1979), 2013, Volume: 125, Issue:9 Topics: Angiotensin I; Animals; Cardiomegaly; Imidazoles; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Rats; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Vasodilation	2013
Mechanisms of the anti-inflammatory actions of the angiotensin type 1 receptor antagonist losartan in experimental models of arthritis. Peptides, 2013, Volume: 46 Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Adhesion; Chemokine CXCL1; Disease Models, Animal; Female; Hyperalgesia; Inflammation; Interleukin-1beta; Leukocyte Rolling; Losartan; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Tumor Necrosis Factor-alpha	2013
Beneficial effects of the activation of the angiotensin-(1-7) MAS receptor in a murine model of adriamycin-induced nephropathy. PloS one, 2013, Volume: 8, Issue:6 Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Doxorubicin; Gene Expression Regulation; Humans; Imidazoles; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Losartan; Mice; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; RNA, Messenger; Time Factors	2013
Angiotensin-(1-7) attenuates lung fibrosis by way of Mas receptor in acute lung injury. The Journal of surgical research, 2013, Volume: 185, Issue:2 Topics: Acute Lung Injury; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Lipopolysaccharides; Losartan; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pulmonary Fibrosis; Receptors, G-Protein-Coupled; Respiratory Distress Syndrome; Vasodilator Agents	2013
Protective effects of angiotensin-(1-7) administrated with an angiotensin-receptor blocker in a rat model of chronic kidney disease. Nephrology (Carlton, Vic.), 2013, Volume: 18, Issue:12 Topics: Angiopoietins; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Fibronectins; Losartan; Male; Nephrectomy; Peptide Fragments; Plasminogen Activator Inhibitor 1; Rats, Sprague-Dawley; Receptor, TIE-2; Renal Insufficiency, Chronic; Systole	2013
ACE2 activity was increased in atherosclerotic plaque by losartan: Possible relation to anti-atherosclerosis. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2015, Volume: 16, Issue:2 Topics: Angiotensin I; Angiotensin-Converting Enzyme 2; Animals; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Humans; Losartan; Male; Myocytes, Smooth Muscle; Peptide Fragments; Peptidyl-Dipeptidase A; Plaque, Atherosclerotic; Rabbits; Signal Transduction	2015
Angiotensin-(1-7) modulates angiotensin II-induced vasoconstriction in human mammary artery. Cardiovascular drugs and therapy, 2014, Volume: 28, Issue:6 Topics: Aged; Aged, 80 and over; Angiotensin I; Angiotensin II; Endothelium, Vascular; Female; Humans; Losartan; Male; Mammary Arteries; Middle Aged; Myocytes, Smooth Muscle; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Vasoconstriction	2014
Comparison of angiotensin-(1-7), losartan and their combination on atherosclerotic plaque formation in apolipoprotein E knockout mice. Atherosclerosis, 2015, Volume: 240, Issue:2 Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Abdominal; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Blood Pressure; Cell Line; Cell Movement; Cell Proliferation; Diet, High-Fat; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Humans; Lipids; Losartan; Macrophages; Male; Mice, Knockout; Muscle, Smooth, Vascular; Peptide Fragments; Plaque, Atherosclerotic; Renin-Angiotensin System; Superoxides; Time Factors; Vasodilation	2015
Angiotensin-(1-7) enhances the effects of angiotensin II on the cardiac sympathetic afferent reflex and sympathetic activity in rostral ventrolateral medulla in renovascular hypertensive rats. Journal of the American Society of Hypertension : JASH, 2015, Volume: 9, Issue:11 Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Drug Interactions; Hypertension, Renovascular; Losartan; Male; Medulla Oblongata; Peptide Fragments; Random Allocation; Rats; Rats, Sprague-Dawley; Reflex; Sympathetic Nervous System; Treatment Outcome	2015
Angiotensin-(1-7)/Mas axis modulates fear memory and extinction in mice. Neurobiology of learning and memory, 2016, Volume: 127 Topics: Acoustic Stimulation; Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Avoidance Learning; Conditioning, Classical; Electroshock; Extinction, Psychological; Fear; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled	2016
The renin-angiotensin system and its vasoactive metabolite angiotensin-(1-7) in the mechanism of the healing of preexisting gastric ulcers. The involvement of Mas receptors, nitric oxide, prostaglandins and proinflammatory cytokines. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2016, Volume: 67, Issue:1 Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Cytokines; Enzyme Inhibitors; Gastric Mucosa; Imidazoles; Indomethacin; Interleukin-1beta; Lisinopril; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Prostaglandins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Stomach Ulcer; Superoxide Dismutase; Tumor Necrosis Factor-alpha	2016
Angiotensin-(1-7)/Mas receptor as an antinociceptive agent in cancer-induced bone pain. Pain, 2016, Volume: 157, Issue:12 Topics: Analgesics; Analysis of Variance; Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Bone Neoplasms; Cancer Pain; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Imidazoles; Losartan; Mice; Mice, Inbred BALB C; Nesting Behavior; Peptide Fragments; Pyridines; Rotarod Performance Test	2016
Influence of antihypertensive drugs on aortic and coronary effects of Ang-(1-7) in pressure-overloaded rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2017, Mar-23, Volume: 50, Issue:4 Topics: Amlodipine; Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta, Abdominal; Blood Pressure; Calcium Channel Blockers; Captopril; Coronary Vessels; Losartan; Male; Mineralocorticoid Receptor Antagonists; Models, Animal; Peptide Fragments; Rats, Wistar; Reproducibility of Results; Spironolactone; Time Factors; Vasoconstriction; Vasodilation	2017
The ACE-2/Ang1-7/Mas cascade enhances bone structure and metabolism following angiotensin-II type 1 receptor blockade. European journal of pharmacology, 2017, Jul-15, Volume: 807 Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Female; Femur; Losartan; Minerals; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Renin-Angiotensin System	2017
Intrarenal Mas and AT Experimental physiology, 2017, 12-01, Volume: 102, Issue:12 Topics: Anesthesia, General; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Diet, Sodium-Restricted; Glomerular Filtration Rate; Hemodynamics; Infusions, Parenteral; Kidney; Losartan; Male; Natriuresis; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Renal Circulation; Renal Elimination; Renin-Angiotensin System; Signal Transduction; Sodium, Dietary	2017
Severe food restriction activates the central renin angiotensin system. Physiological reports, 2020, Volume: 8, Issue:1 Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Arterial Pressure; Autoradiography; Caloric Restriction; Female; Heart Rate; Hypothalamus; Injections, Intraventricular; Losartan; Organum Vasculosum; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Peptidyl-Dipeptidase A; Preoptic Area; Rats; Rats, Inbred F344; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Starvation; Subfornical Organ	2020
N-Acetyl-Seryl-Asparyl-Lysyl-Proline regulates lung renin angiotensin system to inhibit epithelial-mesenchymal transition in silicotic mice. Toxicology and applied pharmacology, 2020, 12-01, Volume: 408 Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cell Line; Epithelial-Mesenchymal Transition; Fibrosis; Losartan; Lung; Male; Mice, Inbred C57BL; Oligopeptides; Peptide Fragments; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Silicosis	2020
Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats. Behavioural brain research, 2021, 01-15, Volume: 397 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Behavior, Animal; Corticomedial Nuclear Complex; Imidazoles; Losartan; Male; Maze Learning; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Swimming	2021
Angiotensin Type 2 and Mas Receptor Activation Prevents Myocardial Fibrosis and Hypertrophy through the Reduction of Inflammatory Cell Infiltration and Local Sympathetic Activity in Angiotensin II-Dependent Hypertension. International journal of molecular sciences, 2021, Dec-20, Volume: 22, Issue:24 Topics: Angiotensin I; Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Hypertension; Imidazoles; Injections, Intraperitoneal; Losartan; Male; Peptide Fragments; Proto-Oncogene Mas; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiophenes; Tyrosine 3-Monooxygenase	2021