Page last updated: 2024-09-03

angiotensin ii, des-phe(8)- and candesartan

angiotensin ii, des-phe(8)- has been researched along with candesartan in 15 studies

Compound Research Comparison

Studies
(angiotensin ii, des-phe(8)-)
Trials
(angiotensin ii, des-phe(8)-)
Recent Studies (post-2010)
(angiotensin ii, des-phe(8)-)
Studies
(candesartan)
Trials
(candesartan)
Recent Studies (post-2010) (candesartan)
1,533219951,929412589

Protein Interaction Comparison

ProteinTaxonomyangiotensin ii, des-phe(8)- (IC50)candesartan (IC50)
Epidermal growth factor receptorHomo sapiens (human)3.2769
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)5.9472
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)3.0652
Cytochrome P450 3A4Homo sapiens (human)9
Adenosine receptor A3Homo sapiens (human)1.2199
Cytochrome P450 2C9 Homo sapiens (human)3
Beta-3 adrenergic receptorHomo sapiens (human)4.3
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)1.2199
Alpha-2B adrenergic receptorHomo sapiens (human)3.843
Sodium-dependent noradrenaline transporter Homo sapiens (human)3.0652
Thromboxane-A synthase Homo sapiens (human)3.0594
Type-1 angiotensin II receptorHomo sapiens (human)0.0405
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)1.2199

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (46.67)29.6817
2010's8 (53.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bader, M; Baltatu, O; Caligiorne, SM; Campagnole-Santos, MJ; Fontes, MA; Ganten, D; Santos, RA1
Ardaillou, R; Chansel, D; Curat, C; Oko, A; Vandermeersch, S1
DiBona, GF; Jones, SY1
Gaspari, TA; Walters, PE; Widdop, RE1
Averill, DB; Diz, DI; Ferrario, CM; Gallagher, PE; Kasper, SO; Sakima, A; Tommasi, EN1
Ebinger, G; Hristova, I; Michotte, Y; Sarre, S; Stragier, B1
Arnold, AC; Diz, DI; Ferrario, CM; Ganten, D; Sakima, A1
Arnold, AC; Chappell, MC; Diz, DI; Isa, K; Westwood, BM1
Baumann, M; Heemann, U; Hermans, JJ; Lutz, J; Rusai, K; Schmaderer, C1
Chappell, MC; Diz, DI; Rose, JC; Shaltout, HA1
Bell, JF; Carey, RM; Howell, NL; Kemp, BA; Navar, LG; Padia, SH; Rottkamp, DM; Shao, W1
Chappell, MC; de Lima, DC; Diz, DI; do Nascimento, K; Nautiyal, M; Shaltout, HA1
Harris, RA; Sullivan, JC; Zimmerman, MA1
da Silva, CHTP; de Oliveira, AM; do Prado, AF; Gerlach, RF; Gomes, MS; Pernomian, L1
Chappell, MC; Diz, DI; Nautiyal, M; Shaltout, HA1

Other Studies

15 other study(ies) available for angiotensin ii, des-phe(8)- and candesartan

ArticleYear
Angiotensin peptides acting at rostral ventrolateral medulla contribute to hypertension of TGR(mREN2)27 rats.
    Physiological genomics, 2000, Apr-27, Volume: 2, Issue:3

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Heart Rate; Hypertension; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles

2000
Effects of angiotensin IV and angiotensin-(1-7) on basal and angiotensin II-stimulated cytosolic Ca2+ in mesangial cells.
    European journal of pharmacology, 2001, Mar-02, Volume: 414, Issue:2-3

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Calcium; Cell Culture Techniques; Cytosol; Dose-Response Relationship, Drug; Glomerular Mesangium; Inositol Phosphates; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Vasoconstrictor Agents

2001
Sodium intake influences hemodynamic and neural responses to angiotensin receptor blockade in rostral ventrolateral medulla.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:4

    Topics: Angiotensin I; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Baroreflex; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Heart Failure; Heart Rate; Hemodynamics; Kidney; Losartan; Male; Medulla Oblongata; Microinjections; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Sodium, Dietary; Sympathetic Nervous System; Tetrazoles

2001
Angiotensin-(1-7) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats.
    Hypertension (Dallas, Tex. : 1979), 2005, Volume: 45, Issue:5

    Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Drug Combinations; Imidazoles; Male; Peptide Fragments; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 2; Tetrazoles; Vasoconstrictor Agents

2005
Impaired heart rate baroreflex in older rats: role of endogenous angiotensin-(1-7) at the nucleus tractus solitarii.
    Hypertension (Dallas, Tex. : 1979), 2005, Volume: 46, Issue:2

    Topics: Aging; Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Baroreflex; Benzimidazoles; Biphenyl Compounds; Heart Rate; Injections; Male; Neprilysin; Peptide Fragments; Rats; Rats, Sprague-Dawley; RNA, Messenger; Solitary Nucleus; Tetrazoles

2005
In vivo characterization of the angiotensin-(1-7)-induced dopamine and gamma-aminobutyric acid release in the striatum of the rat.
    The European journal of neuroscience, 2005, Volume: 22, Issue:3

    Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Chromatography; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; gamma-Aminobutyric Acid; Imidazoles; Male; Microdialysis; NG-Nitroarginine Methyl Ester; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Sulfonic Acids; Tetrazoles; Time Factors

2005
Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen.
    Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:5

    Topics: Aging; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Angiotensins; Animals; Animals, Genetically Modified; Baroreflex; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Heart Rate; Male; Neuroglia; Peptide Fragments; Rats; Renin-Angiotensin System; Solitary Nucleus; Tetrazoles

2008
Angiotensin-converting enzyme inhibition, but not AT(1) receptor blockade, in the solitary tract nucleus improves baroreflex sensitivity in anesthetized transgenic hypertensive (mRen2)27 rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2011, Volume: 34, Issue:12

    Topics: Anesthesia; Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Baroreflex; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Heart Rate; Hypertension; Male; Microinjections; Oligopeptides; Peptide Fragments; Rats; Rats, Transgenic; Solitary Nucleus; Tetrazoles

2011
Direct renin inhibition in a rat model of chronic allograft injury.
    Transplantation, 2011, Nov-15, Volume: 92, Issue:9

    Topics: Amides; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Fumarates; Kidney; Kidney Transplantation; Male; Models, Animal; Peptide Fragments; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptors, Angiotensin; Renin; Renin-Angiotensin System; Tetrazoles; Transplantation, Homologous

2011
Angiotensin-(1-7) deficiency and baroreflex impairment precede the antenatal Betamethasone exposure-induced elevation in blood pressure.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:2

    Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Baroreflex; Benzimidazoles; Betamethasone; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Female; Glucocorticoids; Heart Rate; Hypertension; Peptide Fragments; Pregnancy; Prenatal Exposure Delayed Effects; Receptor, Angiotensin, Type 1; Sheep; Tetrazoles

2012
Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:2

    Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin III; Animals; Benzimidazoles; Biphenyl Compounds; Female; Imidazoles; Kidney Tubules, Proximal; Models, Animal; Natriuresis; Peptide Fragments; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Tetrazoles

2012
Central angiotensin-(1-7) improves vagal function independent of blood pressure in hypertensive (mRen2)27 rats.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:5

    Topics: Angiotensin I; Animals; Antihypertensive Agents; Antioxidants; Baroreflex; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blotting, Western; Cerebrospinal Fluid; Cyclic N-Oxides; Heart Rate; Hypertension; Infusions, Intraventricular; Medulla Oblongata; Mice; Mitogen-Activated Protein Kinases; NADPH Oxidases; Peptide Fragments; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Reactive Oxygen Species; Renin; Spin Labels; Tetrazoles; Vagus Nerve

2012
Female spontaneously hypertensive rats are more dependent on ANG (1-7) to mediate effects of low-dose AT1 receptor blockade than males.
    American journal of physiology. Renal physiology, 2014, May-15, Volume: 306, Issue:10

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cell Adhesion Molecules; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hypertension; Male; Membrane Proteins; Peptide Fragments; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Sex Factors; Tetrazoles

2014
MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS axis functionality.
    European journal of pharmacology, 2015, Oct-05, Volume: 764

    Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Animals; Aorta, Thoracic; Apolipoproteins E; Atherosclerosis; Benzimidazoles; Biphenyl Compounds; Cardiotonic Agents; Cholesterol; Cytokines; Male; Mice, Inbred C57BL; Mice, Knockout; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Tetrazoles; Triglycerides; Vascular Cell Adhesion Molecule-1

2015
Comparison of Candesartan and Angiotensin-(1-7) Combination to Mito-TEMPO Treatment for Normalizing Blood Pressure and Sympathovagal Balance in (mREN2)27 Rats.
    Journal of cardiovascular pharmacology, 2019, Volume: 73, Issue:3

    Topics: Angiotensin I; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Arterial Pressure; Baroreflex; Benzimidazoles; Biphenyl Compounds; Brain; Disease Models, Animal; Drug Combinations; Free Radical Scavengers; Heart; Heart Rate; Hypertension; Male; Mitochondria; Organophosphorus Compounds; Peptide Fragments; Piperidines; Rats, Transgenic; Reactive Oxygen Species; Renin; Sympathetic Nervous System; Tetrazoles; Vagus Nerve

2019