angiotensin-i and nicotianamine

angiotensin-i has been researched along with nicotianamine* in 1 studies

Other Studies

1 other study(ies) available for angiotensin-i and nicotianamine

ArticleYear
Studies on the mechanism of antihypertensive action by nicotianamine.
    Journal of nutritional science and vitaminology, 2010, Volume: 56, Issue:4

    Nicotianamine (NA), which is obtained from vegetables, lowers blood pressure through the renin-angiotensin system, and we clarified that NA preferentially inhibits the activity of angiotensin I-converting enzyme (ACE)-a zinc-containing enzyme. In this study, we elucidated the mechanism of antihypertensive action of NA through the Magnus method by using rat aortic blood vessels. Angiotensin I-induced contractions were inhibited by NA in a concentration-dependant manner. Because NA did not inhibit angiotensin II-induced contractions, it was believed that NA inhibited ACE activity in vascular smooth muscles. NA did not affect KCl-induced contractions, but it affected norepinephrine-induced contractions to a small extent. NA exerted similar effects on endothelium-denuded and endothelium-intact blood vessels. Therefore, the antihypertensive action of NA did not play a role in the opening of voltage-dependent calcium channels, but this effect influenced vasoconstriction by the activation of α-adrenergic receptors. These results suggest that after absorption from the intestinal tract, NA may exert antihypertensive effects via 2 mechanisms: direct inhibition of ACE in vascular smooth muscle and activation of α-adrenergic receptors.

    Topics: Adrenergic alpha-Agonists; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta; Azetidinecarboxylic Acid; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Plant Extracts; Potassium Chloride; Rats; Rats, Wistar; Vasoconstriction

2010
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