angiotensin-i and fasudil

angiotensin-i has been researched along with fasudil* in 2 studies

Other Studies

2 other study(ies) available for angiotensin-i and fasudil

Article	Year
Reversal of Bone Marrow Mobilopathy and Enhanced Vascular Repair by Angiotensin-(1-7) in Diabetes. Diabetes, 2017, Volume: 66, Issue:2 The angiotensin (ANG)-(1-7)/Mas receptor (MasR) pathway activates vascular repair-relevant functions of bone marrow progenitor cells. We tested the effects of ANG-(1-7) on mobilization and vasoreparative functions of progenitor cells that are impaired in diabetes. The study was performed in streptozotocin-induced diabetic (db/db) mice. Diabetes resulted in a decreased number of Lineage Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin I; Animals; Blood Vessels; Bone Marrow; Bone Marrow Cells; Cell Lineage; Cell Movement; Chemokine CXCL12; Diabetes Mellitus, Experimental; Ischemia; Male; Membrane Proteins; Mice; Neovascularization, Physiologic; Peptide Fragments; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptors, G-Protein-Coupled; Recovery of Function; Regeneration; rho-Associated Kinases; Stem Cells; Vascular Endothelial Growth Factor A; Vasodilator Agents	2017
Fasudil alleviated hypoxia-induced pulmonary hypertension by stabilizing the expression of angiotensin-(1-7) in rats. European review for medical and pharmacological sciences, 2016, Volume: 20, Issue:15 The aim of this study was to investigate the mechanism of fasudil alleviating hypoxic pulmonary hypertension (HPH).. A total of 50 Sprague-Dawley rats were randomized into control, model and fasudil intervention groups. Hemodynamic and pulmonary pathomorphology data were collected using Powerlab system and hematoxylin and eosin staining. The protein expression of Ang-(1-7) was detected by immunohistochemical staining and ELISA assay in vivo or in vitro. Western blot was utilized to observe the protein expression of ACE2 and HIF-1α in vitro.. Fasudil treatment repressed the elevation of RVSP, RV/(LV+S), attenuated the pulmonary vascular structure remodeling (PVSR) of pulmonary arterioles induced by chronic hypoxia, and stabilized the expression of Ang-(1-7) in vivo and in vitro. In addition, experiments consistently indicated an escalation of ACE2 and a reduction of HIF-1α.. Our results suggest that fasudil can effectively attenuate PVSR and PH. The underlying mechanism may partially up-regulated Ang-(1-7) and ACE2, and lessened HIF-1α. Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin I; Animals; Gene Expression; Hypertension, Pulmonary; Hypoxia; Peptide Fragments; Rats; Rats, Sprague-Dawley; Signal Transduction	2016

Article

Year

Reversal of Bone Marrow Mobilopathy and Enhanced Vascular Repair by Angiotensin-(1-7) in Diabetes.

Diabetes, 2017, Volume: 66, Issue:2

The angiotensin (ANG)-(1-7)/Mas receptor (MasR) pathway activates vascular repair-relevant functions of bone marrow progenitor cells. We tested the effects of ANG-(1-7) on mobilization and vasoreparative functions of progenitor cells that are impaired in diabetes. The study was performed in streptozotocin-induced diabetic (db/db) mice. Diabetes resulted in a decreased number of Lineage

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin I; Animals; Blood Vessels; Bone Marrow; Bone Marrow Cells; Cell Lineage; Cell Movement; Chemokine CXCL12; Diabetes Mellitus, Experimental; Ischemia; Male; Membrane Proteins; Mice; Neovascularization, Physiologic; Peptide Fragments; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptors, G-Protein-Coupled; Recovery of Function; Regeneration; rho-Associated Kinases; Stem Cells; Vascular Endothelial Growth Factor A; Vasodilator Agents

2017

Fasudil alleviated hypoxia-induced pulmonary hypertension by stabilizing the expression of angiotensin-(1-7) in rats.

European review for medical and pharmacological sciences, 2016, Volume: 20, Issue:15

The aim of this study was to investigate the mechanism of fasudil alleviating hypoxic pulmonary hypertension (HPH).. A total of 50 Sprague-Dawley rats were randomized into control, model and fasudil intervention groups. Hemodynamic and pulmonary pathomorphology data were collected using Powerlab system and hematoxylin and eosin staining. The protein expression of Ang-(1-7) was detected by immunohistochemical staining and ELISA assay in vivo or in vitro. Western blot was utilized to observe the protein expression of ACE2 and HIF-1α in vitro.. Fasudil treatment repressed the elevation of RVSP, RV/(LV+S), attenuated the pulmonary vascular structure remodeling (PVSR) of pulmonary arterioles induced by chronic hypoxia, and stabilized the expression of Ang-(1-7) in vivo and in vitro. In addition, experiments consistently indicated an escalation of ACE2 and a reduction of HIF-1α.. Our results suggest that fasudil can effectively attenuate PVSR and PH. The underlying mechanism may partially up-regulated Ang-(1-7) and ACE2, and lessened HIF-1α.

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin I; Animals; Gene Expression; Hypertension, Pulmonary; Hypoxia; Peptide Fragments; Rats; Rats, Sprague-Dawley; Signal Transduction

2016