angiogenin and cellulose-triacetate

Degranulation of polymorphonuclear leukocytes (PMNL) occurs during extracorporeal circulation. A degranulation-inhibiting protein identical to angiogenin was recently isolated from high-flux dialyzer ultrafiltrate. This protein inhibits the release of lactoferrin and metalloproteinases from PMNL in vitro. In the present study, we investigated end-stage renal disease patients undergoing regular hemodialysis treatment with either high-flux dialyzers (n = 51) or low-flux dialyzers (n = 44), and chronically uremic patients undergoing hemodiafiltration (n = 30). Hemodialysis therapy with low-flux polysulfone or cellulose triacetate membranes caused no or only minimal reduction (

Topics: Adult; Aged; Aged, 80 and over; Azo Compounds; Cell Degranulation; Cellulose; Extracorporeal Circulation; Female; Humans; Kidney Failure, Chronic; Lactoferrin; Leukocyte Elastase; Male; Membranes, Artificial; Middle Aged; Neutrophils; Polymers; Renal Dialysis; Ribonuclease, Pancreatic; Sulfones