Page last updated: 2024-08-17

androstenedione and metyrapone

androstenedione has been researched along with metyrapone in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199025 (73.53)18.7374
1990's6 (17.65)18.2507
2000's1 (2.94)29.6817
2010's0 (0.00)24.3611
2020's2 (5.88)2.80

Authors

AuthorsStudies
Belvedere, PC; Colombo, L1
Bertrand, J; Darsy, P; de Peretti, E; Forest, MG; Tourniaire, J1
Ernster, L; Gustafsson, JA; Hrycay, EG; Ingelman-Sundberg, M1
Andersen, RN; Givens, JR; Ragland, JB; Umstot, ES1
Durand, F; Mowszowicz, I; Schaison, G1
deAsis, DN; Samaan, NA1
Grover, PK; Odell, WD; Parker, LN1
Beyer, C; Larsson, K; Moralí, G; Naftolin, F1
Canick, JA; Ryan, KJ1
Anderson-Langmuir, CE; Etches, RJ; Petitte, JN1
Bertagna, X; Cunningham, SK; Girard, F; Loughlin, T; McKenna, TJ1
Challis, JR; Lukash, L; Lye, SJ; Mitchell, BF1
Doorenbos, H; Sleijfer, DT; Sluiter, WJ; van der Ploeg, E; van Veelen, H; Willemse, PH1
Baker, RS; Bonin, AM; Murray, M; Reidy, GF; Rose, HA; Stacey, NH1
O'Brien, PJ; Rahimtula, AD1
Bachmann, R; Gennser, G; Hökfelt, B; Nilsson, KO; Sternby, NH1
Siiteri, PK; Thompson, EA1
Gower, DB1
Carballeira, A; Cheng, SC; Fishman, LM1
Carballeira, A; Durnhofer, F; Fishman, LM1
Jeffries, CD; Wilkins, J1
Satre, M; Vignais, PV1
de Lange, WE; Doorenbos, H; Pratt, JJ; Sluiter, WJ1
Brerault, JL; Cathelineau, G; Dreux, C; Fiet, J; Gourmel, B; Julien, R; Villette, JM1
Butt, WR; Holder, G; Horrocks, PM; Kandeel, FR; Logan-Edwards, R; London, DR; Lynch, SS1
DePierre, JW; Meijer, J1
Auzéby, A; Bogdan, A; Touitou, Y1
Forkert, PG; Jellinck, PH; Martucci, CP; Newcombe, AM1
Miura, K; Morita, H; Mune, T; Murayama, M; Yamakita, N; Yasuda, K1
Boyle, T; Dukes, M; Edwards, PN; Large, M; Smith, IK1
Butler, AM; Martini, R; Murray, M; Sefton, RM1
Berry, J; Breu, J; Eaton, K; Grinspoon, S; Koutkia, P1
Assié, G; Baron, S; Bertherat, J; Bessiene, L; Blanchet, B; Bonnet-Serrano, F; Bricaire, L; Groussin, L; Guibourdenche, J; Guignat, L; Laguillier-Morizot, C; Poirier, J; Vaczlavik, A1
Adaway, JE; Auer, MK; Bidlingmaier, M; Braun, L; Hartmann, MF; Hawley, J; Keevil, B; Lottspeich, C; Nowotny, HF; Reincke, M; Reisch, N; Schilbach, K; Tschaidse, L; Vogel, F; Wudy, SA1

Reviews

1 review(s) available for androstenedione and metyrapone

ArticleYear
Modifiers of steroid-hormone metabolism: a review of their chemistry, biochemistry and clinical applications.
    Journal of steroid biochemistry, 1974, Volume: 5, Issue:5

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aminoglutethimide; Androgens; Androstenedione; Animals; Cholesterol; Dexamethasone; Estrogens; Estrone; Glutethimide; Hormones; Humans; Hydrocortisone; Methane; Metyrapone; Microscopy, Electron; Pharmacology; Phenols; Pregnenolone; Pyridines; Steroid Hydroxylases; Steroids; Time Factors

1974

Trials

1 trial(s) available for androstenedione and metyrapone

ArticleYear
Increased adrenal androgen secretion with inhibition of 11beta-hydroxylase in HIV-infected women.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 290, Issue:5

    Topics: Adolescent; Adrenal Glands; Adult; Androgens; Androstenedione; Cortodoxone; Cosyntropin; Dehydroepiandrosterone; Double-Blind Method; Enzyme Inhibitors; Female; HIV Infections; Humans; Hydrocortisone; Metyrapone; Middle Aged; Steroid 11-beta-Hydroxylase; Testosterone; Time Factors

2006

Other Studies

32 other study(ies) available for androstenedione and metyrapone

ArticleYear
Steroid biosynthesis by the ovary of the European eel, Anguilla anguilla L., at the silver stage.
    General and comparative endocrinology, 1976, Volume: 28, Issue:4

    Topics: 17-alpha-Hydroxypregnenolone; Androstanes; Androstenedione; Androsterone; Animals; Dehydroepiandrosterone; Eels; Female; Hydroxyprogesterones; Kinetics; Metyrapone; Ovary; Pregnenes; Pregnenolone; Progesterone; Testosterone

1976
[Comparison of plasma testosterone (T), androstenedione (A) and dhea variations after métopirone in 10 normal and 12 hirsute women (author's transl)].
    Annales d'endocrinologie, 1977, Volume: 38, Issue:6

    Topics: Administration, Oral; Androstenedione; Dehydroepiandrosterone; Female; Hirsutism; Humans; Metyrapone; Testosterone

1977
The involvement of cytochrome P-450 in hepatic microsomal steroid hydroxylation reactions supported by sodium periodate, sodium chlorite, and organic hydroperoxides.
    European journal of biochemistry, 1976, Jan-02, Volume: 61, Issue:1

    Topics: Acetone; Amines; Androstenedione; Aniline Compounds; Animals; Chlorine; Cytochrome P-450 Enzyme System; Estradiol; Kinetics; Male; Metyrapone; Microsomes, Liver; Periodic Acid; Peroxides; Progesterone; Rats; Spectrophotometry; Steroid Hydroxylases; Testosterone

1976
Effects of norgestrel and metyrapone on pituitary-adrenal-ovarian function.
    Obstetrics and gynecology, 1976, Volume: 48, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androstenedione; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Humans; Hydrocortisone; Luteinizing Hormone; Metyrapone; Norgestrel; Ovary; Pituitary Gland; Protein Binding; Secretory Rate; Testosterone

1976
Effect of glucocorticoids on plasma testosterone in men.
    Acta endocrinologica, 1978, Volume: 89, Issue:1

    Topics: Adrenocorticotropic Hormone; Adult; Androstenedione; Chorionic Gonadotropin; Dexamethasone; Humans; Hydrocortisone; Luteinizing Hormone; Male; Metyrapone; Middle Aged; Testosterone

1978
Feminizing adrenocortical carcinoma with Cushing's syndrome and pseudohyperparathyroidism.
    Archives of internal medicine, 1978, Volume: 138, Issue:2

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adult; Aminoglutethimide; Androstenedione; Cushing Syndrome; Dexamethasone; Estrogens; Feminization; Humans; Hyperparathyroidism; Male; Metyrapone; Mitotane; Paraneoplastic Endocrine Syndromes; Parathyroid Hormone; Testosterone

1978
An improved radioimmunoassay for 4-androstene-3,17-dione.
    Steroids, 1977, Volume: 29, Issue:6

    Topics: Adult; Androstenedione; Dexamethasone; Humans; Metyrapone; Radioimmunoassay

1977
Effect of some antiestrogens and aromatase inhibitors on androgen induced sexual behavior in castrated male rats.
    Hormones and behavior, 1976, Volume: 7, Issue:3

    Topics: Aminoglutethimide; Androstenedione; Animals; Castration; Clomiphene; Drug Interactions; Ejaculation; Ethamoxytriphetol; Male; Metyrapone; Rats; Sexual Behavior, Animal; Tamoxifen; Testosterone; Time Factors

1976
Cytochrome P-450 and the aromatization of 16alpha-hydroxytestosterone and androstenedione by human placental microsomes.
    Molecular and cellular endocrinology, 1976, Volume: 6, Issue:2

    Topics: Androstenedione; Aromatase; Carbon Monoxide; Cytochrome P-450 Enzyme System; Female; Humans; Hydroxytestosterones; Kinetics; Metyrapone; Microsomes; Placenta; Pregnancy; Spectrophotometry; Testosterone

1976
Effect of metyrapone on the timing of oviposition and ovarian steroidogenesis in the laying hen.
    British poultry science, 1991, Volume: 32, Issue:4

    Topics: Androstenedione; Animals; Cells, Cultured; Chickens; Estradiol; Female; Gonadal Steroid Hormones; Granulosa Cells; Light; Luteinizing Hormone; Metyrapone; Ovarian Follicle; Ovary; Oviposition; Periodicity; Progesterone

1991
Plasma pro-opiomelanocortin fragments and adrenal steroids following administration of metyrapone to normal and hirsute women.
    Journal of endocrinological investigation, 1988, Volume: 11, Issue:4

    Topics: Administration, Oral; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androstenedione; beta-Endorphin; beta-Lipotropin; Cortodoxone; Dexamethasone; Estradiol; Estrone; Female; Hirsutism; Humans; Metyrapone; Peptide Fragments; Pro-Opiomelanocortin; Testosterone

1988
Androstenedione metabolism in the late gestation sheep fetus.
    Endocrinology, 1986, Volume: 118, Issue:1

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Androstenedione; Animals; Estrone; Female; Fetal Blood; Fetus; Gestational Age; Metabolic Clearance Rate; Metyrapone; Pregnancy; Testosterone; Umbilical Arteries; Umbilical Veins

1986
Mechanism of adrenal suppression by high-dose medroxyprogesterone acetate in breast cancer patients.
    Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:2

    Topics: 17-alpha-Hydroxyprogesterone; Adrenal Insufficiency; Aged; Androstenedione; Breast Neoplasms; Cosyntropin; Female; Humans; Hydrocortisone; Hydroxyprogesterones; Medroxyprogesterone; Medroxyprogesterone Acetate; Metyrapone; Middle Aged

1985
Identification of the hepatic cytochrome P-450 isozymes induced and decreased by picloram.
    Biochemical pharmacology, 1988, Mar-15, Volume: 37, Issue:6

    Topics: Androstenedione; Aniline Hydroxylase; Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Female; Isoenzymes; Liver; Male; Metyrapone; Molecular Weight; Mutagens; Picloram; Picolinic Acids; Quinolines; Rats; Rats, Inbred Strains; Sex Factors

1988
Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450.
    Biochemical and biophysical research communications, 1974, Sep-09, Volume: 60, Issue:1

    Topics: Androstenedione; Aniline Compounds; Animals; Benzopyrenes; Coumarins; Cyanides; Cytochrome P-450 Enzyme System; Edetic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygen Consumption; Peroxides; Phenobarbital; Phenols; Phenylenediamines; Proadifen; Rabbits; Rats; Sodium Dodecyl Sulfate; Species Specificity; Superoxide Dismutase; Time Factors

1974
Steroid studies in a case of ovarian hyperluteinization with virilism in two consecutive pregnancies.
    Acta endocrinologica, 1974, Volume: 76, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Androstenedione; Biopsy; Cesarean Section; Chorionic Gonadotropin; Depression, Chemical; Dexamethasone; Estriol; Female; Hair; Humans; Hydrocortisone; Menotropins; Metyrapone; Ovary; Pregnancy; Pregnancy Complications; Pregnanetriol; Stimulation, Chemical; Testosterone; Virilism

1974
The involvement of human placental microsomal cytochrome P-450 in aromatization.
    The Journal of biological chemistry, 1974, Sep-10, Volume: 249, Issue:17

    Topics: Aminoglutethimide; Androstenedione; Animals; Binding Sites; Binding, Competitive; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Female; Humans; Kinetics; Metyrapone; Microsomes; Microsomes, Liver; Nandrolone; Placenta; Pregnancy; Proadifen; Protein Binding; Rabbits; Receptors, Cell Surface; Spectrophotometry; Spectrophotometry, Ultraviolet; Steroids; Swine; Tritium

1974
Metabolism of (4-14C) cholesterol by human adrenal glands in vitro and its inhibition by metyrapone.
    Acta endocrinologica, 1974, Volume: 76, Issue:4

    Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adrenocortical Hyperfunction; Adult; Androstenedione; Carbon Radioisotopes; Cholesterol; Chromatography, Paper; Chromatography, Thin Layer; Corticosterone; Depression, Chemical; Desoxycorticosterone; Female; Humans; Hydrocortisone; In Vitro Techniques; Metyrapone; Middle Aged; Pregnenolone; Progesterone; Tritium

1974
Effects of aminoglutethimide, metyrapone, and ascorbic acid on testicular metabolism of cholesterol.
    Metabolism: clinical and experimental, 1974, Volume: 23, Issue:12

    Topics: Aminoglutethimide; Androstanes; Androstenedione; Animals; Ascorbic Acid; Carbon Radioisotopes; Cell-Free System; Cholesterol; Chromatography, Paper; Chromatography, Thin Layer; Female; Hydroxyprogesterones; Hydroxysteroids; Male; Metyrapone; Mitochondria; Pregnenolone; Progesterone; Rats; Testis; Testosterone; Tritium

1974
Effect of exogenous steroids and inhibitors of steroidogenesis on endotoxin shock.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1973, Volume: 142, Issue:2

    Topics: Adrenal Cortex Hormones; Adrenal Glands; Aminoglutethimide; Androstenedione; Animals; Butanones; Corticosterone; Desoxycorticosterone; Endotoxins; Hydrocortisone; Hydroxyprogesterones; Lethal Dose 50; Male; Metyrapone; Mice; Mice, Inbred ICR; Pregnenes; Pregnenolone; Progesterone; Shock, Septic

1973
Steroid 11beta-hydroxylation in beef adrenal cortex mitochondria. Binding affinity and capacity of specific (14C)steroids and for (3H)metyrapol, an inhibitor of the 11beta-hydroxylation reaction.
    Biochemistry, 1974, May-07, Volume: 13, Issue:10

    Topics: Adrenal Glands; Androstenedione; Animals; Binding Sites; Binding, Competitive; Carbon Radioisotopes; Cattle; Cholesterol; Cyclohexanes; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Hydroxylation; Metyrapone; Microsomes; Mitochondria; Nitriles; Steroid Hydroxylases; Steroids; Structure-Activity Relationship; Testosterone; Thermodynamics; Tritium

1974
Plasma 11-deoxycortisol, androstenedione, testosterone and ACTH in comparison with the urinary excretion of tetrahydro-11-deoxycortisol as indices of the pituitary-adrenal response to oral metyrapone.
    Acta endocrinologica, 1980, Volume: 93, Issue:4

    Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Androstenedione; Cortodoxone; Female; Humans; Hydrocortisone; Male; Metyrapone; Middle Aged; Pituitary Neoplasms; Pituitary-Adrenal System; Testosterone; Tetrahydrocortisol; Time Factors

1980
Simultaneous radioimmunoassay of androstenedione, dehydroepiandrosterone and 11-beta-hydroxyandrostenedione in plasma.
    Hormone research, 1980, Volume: 13, Issue:3

    Topics: Adrenocorticotropic Hormone; Adult; Aged; Androstenedione; Animals; Child; Child, Preschool; Circadian Rhythm; Contraceptives, Oral; Dehydroepiandrosterone; Dexamethasone; Endocrine System Diseases; Female; Humans; Infant; Male; Metyrapone; Middle Aged; Rabbits; Radioimmunoassay

1980
Acth function in women with the polycystic ovarian syndrome.
    Clinical endocrinology, 1983, Volume: 19, Issue:2

    Topics: Adolescent; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hydrocortisone; Metyrapone; Polycystic Ovary Syndrome; Testosterone

1983
Comparison of trans-stilbene oxide, phenobarbital and 3-methylcholanthrene as inducers of steroid metabolism by the rat liver microsomal cytochrome P-450 system.
    Journal of steroid biochemistry, 1983, Volume: 18, Issue:4

    Topics: Androstenedione; Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Hydroxylation; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Stilbenes; Testosterone

1983
An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione.
    The Journal of clinical endocrinology and metabolism, 1995, Volume: 80, Issue:5

    Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adult; Aged; Aldehyde-Lyases; Aminoglutethimide; Androstenedione; Carcinoma; Child; Cytochrome P-450 Enzyme System; Female; Humans; Hyperaldosteronism; Male; Metyrapone; Middle Aged; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase

1995
Distinct forms of hepatic androgen 6 beta-hydroxylase induced in the rat by indole-3-carbinol and pregnenolone carbonitrile.
    The Journal of steroid biochemistry and molecular biology, 1994, Volume: 51, Issue:3-4

    Topics: Androstenedione; Androsterone; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Hydroxylation; Immunoblotting; Indoles; Liver; Male; Metyrapone; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Steroid Hydroxylases; Tamoxifen

1994
Elevated plasma 19-hydroxyandrostenedione levels in Cushing's disease: stimulation with ACTH and inhibition with metyrapone.
    Clinical endocrinology, 1993, Volume: 38, Issue:3

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Androstenedione; Blood Pressure; Cushing Syndrome; Depression, Chemical; Dexamethasone; Female; Humans; Hydrocortisone; Male; Metyrapone; Middle Aged

1993
The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)--a potent, selective aromatase inhibitor.
    The Journal of steroid biochemistry and molecular biology, 1996, Volume: 58, Issue:4

    Topics: Adrenal Glands; Aminoglutethimide; Anastrozole; Androstenedione; Animals; Aromatase Inhibitors; Cortodoxone; Enzyme Inhibitors; Fadrozole; Female; Hormones; Humans; Macaca nemestrina; Male; Metyrapone; Nitriles; Organ Size; Potassium; Prostate; Rats; Rats, Wistar; Seminal Vesicles; Sodium; Triazoles; Uterus

1996
Comparative induction of CYP3A and CYP2B in rat liver by 3-benzoylpyridine and metyrapone.
    Chemico-biological interactions, 1998, Jun-05, Volume: 113, Issue:3

    Topics: Androstenedione; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydroxylation; In Vitro Techniques; Liver; Male; Metyrapone; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pyridines; Rats; Rats, Wistar; RNA, Messenger

1998
Differences in the spectrum of steroidogenic enzyme inhibition between Osilodrostat and Metyrapone in ACTH-dependent Cushing syndrome patients.
    European journal of endocrinology, 2022, Aug-01, Volume: 187, Issue:2

    Topics: Adrenocorticotropic Hormone; Androstenedione; Chromatography, Liquid; Cortodoxone; Cushing Syndrome; Female; Humans; Hydrocortisone; Imidazoles; Metyrapone; Pyridines; Steroid 11-beta-Hydroxylase; Steroid 21-Hydroxylase; Tandem Mass Spectrometry; Testosterone

2022
11-Oxygenated C19 steroids are the predominant androgens responsible for hyperandrogenemia in Cushing's disease.
    European journal of endocrinology, 2022, Nov-01, Volume: 187, Issue:5

    Topics: Adrenocorticotropic Hormone; Androgens; Androstenedione; Androsterone; Cortisone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Humans; Hydrocortisone; Hyperandrogenism; Metyrapone; Pituitary ACTH Hypersecretion; Polycystic Ovary Syndrome; Sex Hormone-Binding Globulin; Steroids; Testosterone

2022