androstenedione has been researched along with formestane in 322 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 80 (24.84) | 18.7374 |
| 1990's | 155 (48.14) | 18.2507 |
| 2000's | 55 (17.08) | 29.6817 |
| 2010's | 25 (7.76) | 24.3611 |
| 2020's | 7 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Cole, PA; Robinson, CH | 1 |
| Bednarski, PJ; Nelson, SD | 1 |
| Gynther, J; Honkakoski, P; Jyrkkärinne, J; Mäkinen, J; Poso, A; Savolainen, H | 1 |
| Cepa, MM; Correia-da-Silva, G; Roleira, FM; Tavares da Silva, EJ; Teixeira, NA | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Barmade, MA; Murumkar, PR; Tamboli, RS; Yadav, MR | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Brodie, AM; Brodie, HJ; Schwarzel, WC; Shaikh, AA | 1 |
| Davies, JH; Dowsett, M; Houghton, J; Jarman, M; Poon, GK; Rowlands, MG; Shearer, RJ | 1 |
| Christodoulides, A; Ghilchik, MW; Koistinen, R; Reed, MJ; Seppälä, M; Teale, JD | 1 |
| Bogart, MH; Lance, VA | 1 |
| Borja, J; Pérez, N | 1 |
| Coombes, RC; Dowsett, M; Stein, RC | 1 |
| Dowsett, M; Jacobs, S; Jones, AL; Lonning, PE; MacNeill, F; Powles, TJ | 1 |
| Holman, SD; Hutchison, JB; Wozniak, A | 1 |
| Davies, JH; Heeremans, CE; Jarman, M; McCague, R; Niessen, WM; Poon, GK; van der Greef, J; van der Hoeven, RA | 1 |
| Coombes, RC; Dowsett, M; Hughes, SW | 1 |
| Dowsett, M; Ekse, D; Jacobs, S; Johannessen, DC; Jones, A; Lønning, PE; McNeil, F; Powles, TJ | 1 |
| de Bridges, EF; Fitzpatrick, FT; Greenstein, BD | 1 |
| Coombes, RC; di Salle, E; Evans, TR; Giudici, D; Lassus, M; Ornati, G | 1 |
| Coombes, RC | 2 |
| James, VH; Purohit, A; Reed, MJ | 1 |
| Auclair, MC; Benassayag, C; Carli, A; Christeff, N; Dehennin, L; Nunez, EA; Thobie, N | 1 |
| Coombes, RC; Dowsett, M; King, N; Mehta, A; Powles, TJ; Smith, IE; Stein, RC | 1 |
| Lechuga, M; Motta, M; Zoppi, S | 1 |
| Coombes, RC; Davies, JH; Dowsett, M; Hedley, A; Jacobs, S; Shearer, RJ | 1 |
| Celotti, F; Lechuga, MJ; Martini, L; Melcangi, RC; Motta, M; Negri-Cesi, P; Poletti, A; Zoppi, S | 1 |
| Henderson, D | 2 |
| Coombes, RC; Ford, HT; Gazet, JC | 1 |
| Deckers, GH; Geelen, JA; Kloosterboer, HJ; Loozen, HJ; Tax, LJ; van der Wardt, JT | 1 |
| Anderson, ED; Anderson, TJ; Chetty, U; Forrest, AP; Hawkins, RA; Leonard, RC | 1 |
| Degen, PH; Schneider, W | 1 |
| Dowsett, M; Firth, J; Jarman, M; Poon, GK; Rowlands, MG | 1 |
| Bliss, JM; Coombes, RC; Dowsett, M; Easton, DF; Shah, P; Wilkinson, JR | 1 |
| Aherne, GW; Chakraborty, J; Ghilchik, MW; Patel, S; Reed, MJ | 1 |
| Brodie, A | 1 |
| Doody, KM; Mason, JI; Murry, BA | 1 |
| Geisert, RD; Morgan, GL; O'Neill, LA; Wettemann, RP; Zavy, MT | 1 |
| Castro, O; Devoto, L; Kohen, P; Vega, M | 1 |
| Fukabori, Y; Honma, S; Takezawa, Y | 1 |
| Brandt, ME; Brodie, AM; Melner, MH; Puett, D; Zimniski, SJ | 1 |
| Dowsett, M; Lloyd, P | 1 |
| Dowsett, M; Lønning, PE; Powles, TJ | 1 |
| Braun, DG; Bullion, KA; Osawa, Y | 1 |
| Coldham, NG; Ghilchik, MW; James, VH; Lai, LC; Reed, MJ; Shaikh, NA | 1 |
| Coombes, RC; Dowsett, M; Ford, HT; Gazet, JC; Hedley, A; Stein, RC | 1 |
| Distler, W; von Matthiessen, H | 1 |
| Eidtmann, H; Jonat, W; Kügler, G; Kunz, T; Maass, H | 1 |
| Santen, RJ | 1 |
| Dowsett, M | 4 |
| Becher, R; Callies, R; Friederich, P; Höffken, K; Jonat, W; Kölbel, M; Kunz, T; Possinger, K; Wagner, H; Willmanns, W | 1 |
| Callard, GV; Schlinger, BA | 2 |
| Coombes, RC; Cunningham, D; Davies, JH; Dowsett, M; Hedley, A; Malone, PR; Shearer, RJ | 1 |
| Chen, SA; Pompon, D; Zhou, DJ | 1 |
| Aherne, GW; Chakraborty, J; Khubieh, J | 3 |
| Ayub, M; Levell, MJ | 2 |
| Banks, PK; Brodie, AM; Coombes, RC; Dowsett, M; Inkster, SE | 1 |
| Briatico, G; D'Alessio, R; Di Salle, E; Giudici, D; Lombardi, P; Ornati, G; Villa, V | 1 |
| Sekiba, K; Taga, S; Yoshida, N | 1 |
| Banks, PK; Brodie, AM; Inkster, SE; Koos, RD; Son, C | 1 |
| Coldham, NG; Ghilchik, MW; James, VH; Lai, LC; Owen, AM; Purohit, A; Reed, MJ; Shaikh, NA; Singh, A | 1 |
| Coombes, RC; Davenport, J; Dowsett, M; Ford, HT; Gazet, JC; Hedley, A; Stein, RC | 1 |
| Briatico, G; di Salle, E; Giudici, D; Ornati, G | 1 |
| Murray, P; Perry, L; Pickles, T; Plowman, P | 1 |
| Currie, JC; Henderson, A; Houston, PA; Payne, AP | 1 |
| el Etreby, MF; Habenicht, UF; Neumann, F; Schwarz, K; Schweikert, HU | 1 |
| Cocconi, M; Costantini, A; Martini, L; Motta, M; Natali, A; Serio, M; Zoppi, S | 1 |
| el Etreby, MF; Habenicht, UF; Henderson, D; Kerb, U; Nishino, Y | 1 |
| Bartsch, W; Klein, H; Stürenburg, HJ; Voigt, KD | 1 |
| Brodie, AM; Inkster, SE; King, DA; Meyer, KM; Son, C | 1 |
| Bhatnagar, AS; Häusler, A; Krähenbühl, C; Monnet, G; Schenkel, L | 1 |
| Anderson, ED; Chetty, U; Forrest, AP; Hawkins, RA; Levack, PA | 1 |
| Miller, WR | 1 |
| Lephart, ED; Mathews, D; Noble, JF; Ojeda, SR | 1 |
| Akiyama, I; Sakuma, Y; Takahashi, Y; Yamanaka, H | 1 |
| Guarna, A; Moneti, G; Prucher, D; Salerno, R; Serio, M | 1 |
| Albrecht, ED; Brodie, AM; Ghosh, M; Hammond, JO; Meyer, K | 1 |
| Coldham, NG; Ghilchik, MW; James, VH; Lai, LC; Owen, AM; Reed, MJ; Shaikh, NA | 1 |
| Oakey, RE; Purohit, A | 1 |
| Manni, A; Santen, RJ | 1 |
| Coombes, RC; Cunningham, DC; Dehennin, L; Dowsett, M; Evans, S; Hedley, A; Stein, RC | 1 |
| Armstrong, DT; Glasier, MA; Khalil, MW; Lang, T; Morley, P | 1 |
| Brodie, AM; Coombes, RC; Dowsett, M; Gazet, JC; Goss, PE; Hutchison, G; Powles, TJ | 1 |
| Albrecht, ED; Anderson, LD; Pepe, GJ; Wunsch, DM | 1 |
| Brodie, AM; Catt, KJ; Knecht, M | 1 |
| Longcope, C; Mordes, JP; Orczyk, GP | 1 |
| Brodie, AM; Santen, RJ | 2 |
| Brodie, AM; Hammond, JO; Wing, LY | 1 |
| Bélanger, A; Labrie, F; Marchetti, B; Mérand, Y; Spinola, PG | 1 |
| Iguchi, T; Petrow, V; Takasugi, N; Todoroki, R | 1 |
| el Etreby, MF; Schröder, H; Ziegler, M | 1 |
| Brodie, AH; Griffing, GT; Holbrook, M; Melby, JC | 1 |
| Habib, FK; Houston, B | 1 |
| Brandt, ME; Covey, DF; Fendl, K; Garola, R; Puett, D; Zimniski, SJ | 1 |
| Brodie, AM; Coombes, RC; Dowsett, M | 1 |
| Croxatto, HB; Forcelledo, ML | 2 |
| Miller, WR; O'Neill, J | 1 |
| Coombes, RC; Goss, PE; Jarman, M; Wilkinson, JR | 1 |
| Feil, PD; Leszczynski, D; Manni, A; Santen, RJ; Santner, SJ; Tilson-Mallet, N; Wright, C | 1 |
| Gelly, C; Pasqualini, JR; Sumida, C | 1 |
| Bongiovanni, A; Coney, P; Hosoi, Y; Wallach, E; Yoshimura, Y | 1 |
| France, JT; Magness, RR; Mason, JI; Murry, BA; Rosenfeld, CR | 1 |
| Fair, WR; Fishman, J; Laudone, VP; Stone, NN | 1 |
| Brodie, AM; Coombes, RC; Cunningham, D; Dowsett, M; Ford, HT; Gazet, JC; Hutchison, G; Powles, TJ | 1 |
| Martini, L; Motta, M; Zoppi, S | 1 |
| Brodie, AM; Coombes, RC; Dowsett, M; Goss, P; Wing, LY | 2 |
| Foster, AB; Jarman, M; Mann, J; Parr, IB | 1 |
| Coombes, RC; Easton, D; Goss, PE; Singh, D; Wilkinson, JR; Williams, JC | 1 |
| Carreau, S; Dehennin, L; Drosdowsky, MA; Papadopoulos, V; Scholler, R; Szerman-Joly, E | 1 |
| Brodie, AM; Martini, L; Motta, M; Zoppi, S | 1 |
| Berkovitz, GD; Brodie, AM; Brown, TR; Hsiang, YH; Migeon, CJ | 1 |
| Donahoe, PK; Hutson, JM; MacLaughlin, DT | 1 |
| Brodie, AM | 3 |
| Brodie, AM; Garrett, WM; Wing, LY | 1 |
| Brodie, AM; Hung, TT; Koos, RD; LeMaire, WJ | 1 |
| Brodie, A; Coombes, RC; Dowsett, M; Gazet, JC; Goss, P | 1 |
| Abul-Hajj, YJ | 3 |
| Choi, L; Haning, RV; Kiggens, AJ; Kuzma, DL; Summerville, JW | 2 |
| Wu, JT | 1 |
| Feil, PD; Santen, RJ; Santner, SJ; Tilson-Mallett, N | 1 |
| George, FW; Leshin, M; Noble, JF; Wilson, JD | 1 |
| Brodie, AM; Feiertag, MA; Koos, RD; LeMaire, WJ | 1 |
| Brodie, AM; Garrett, WM; Hendrickson, JR; Tsai-Morris, CH | 1 |
| Bartke, A; Brodie, A; Dalterio, S; Mayfield, D | 1 |
| Brodie, AM; Brodie, HJ; Marsh, DA; Romanoff, L; Williams, KI | 1 |
| Covey, DF; Hood, WF | 2 |
| Covey, DF; Etre, LA; MacIndoe, JH; Woods, GR | 1 |
| Lin, GM; Wu, JT | 1 |
| Brodie, AM; Romanoff, LP; Williams, KI | 1 |
| Covey, DF; Davis, SP; Killinger, DW; Perel, E | 1 |
| Brodie, AM; Garrett, WM; Hendrickson, JR; Marcotte, PA; Robinson, CH; Tsai-Morris, CH | 1 |
| Brodie, AM; Brodie, HJ; Romanoff, L; Williams, JG; Williams, KI; Wu, JT | 1 |
| Brodie, A; Inkster, S; Yue, W | 1 |
| Murray, R; Pitt, P | 2 |
| Brodie, A; Savinov, A; Wang, J; Yue, W | 1 |
| McTavish, D; Wiseman, LR | 1 |
| Bartsch, G; el Etreby, MF; Habenicht, UF; Schröder, FH; Schweikert, HU; Senge, T; Tunn, UW | 1 |
| Dowsett, M; Jacobs, S; Lonning, PE; MacNeill, FA; Powles, TJ | 1 |
| Bajetta, E; Biasi, G; Bichisao, E; Bono, A; Buzzoni, R; Dolci, S; Laffranchi, A; Noberasco, C; Vicario, G; Zilembo, N | 1 |
| Mildvan, AS; Talalay, P; Zhao, Q | 1 |
| Balthazart, J; Foidart, A; Harada, N | 1 |
| Brodie, A; Zhou, JL | 1 |
| Attili, A; Bajetta, E; Bartoli, C; Buzzoni, R; Ferrari, L; Lepera, P; Martinetti, A; Noberasco, C; Sacchini, V; Zilembo, N | 1 |
| Alberola Candel, V; Calabresi, F; Delozier, T; Feuilhade, F; Freue, M; Goss, P; Mauriac, L; Michel, RT; Pérez Carrión, R; Santos, R | 1 |
| Höffken, K; Jonat, W; Possinger, K | 1 |
| Miller, WR; Parker, MG; Sourdaine, P; Telford, J | 1 |
| Bajetta, E; Buzzoni, R; Celio, L; Dolci, S; Ferrari, L; Laffranchi, A; Noberasco, C; Vicario, G; Zilembo, N | 1 |
| Jeyasuria, P; Place, AR; Roosenburg, WM | 1 |
| Reed, MJ | 1 |
| Coombes, RC; Dowsett, M | 1 |
| Bajetta, E; Buzzoni, R; Celio, L; Cerrotta, AM; Ferrari, L; Galante, E; Martinetti, A; Noberasco, C; Orefice, S; Zilembo, N | 1 |
| Junker Walker, U; Nogués, V | 1 |
| Casebolt, TL; Eto, I; Grubbs, CJ; Kelloff, GJ; Lubet, RA; Steele, VE | 1 |
| Bajetta, E; Bartoli, C; Buzzoni, R; Celio, L; Di Leo, A; Merson, M; Moglia, D; Noberasco, C; Sacchini, V; Zilembo, N | 1 |
| Cam, LL; Chen, S; Korzekwa, KR; Laughton, CA; Zhou, D | 1 |
| Adlercreutz, H; Fotsis, T; Johannessen, DC; Lønning, PE | 1 |
| Bhatnagar, AS; King, EJ; Purba, HS; Richert, P | 1 |
| Chander, SK; Coombes, RC; Coope, RC; Gomm, JJ; Gould, N; Lansdown, AG; Luqmani, YA | 1 |
| Dowsett, M; Jacobs, S; Lønning, PE; MacNeill, FA; Powles, TJ | 1 |
| Bridges, Ede F; Coates, PJ; Dhaher, YY; Etherington, J; Greenstein, AS; Greenstein, BD; Hall, PA; Hughes, GR; Keser, G; Khamashta, MA | 1 |
| Bertolini, A; Sandrini, M; Vergoni, AV | 1 |
| Akira, S; Friedman, CI; Hayes, RA; Kim, MH; Lin, YC; Miller, K | 1 |
| Chang, LT; Hsu, CY; Ku, HH; Liu, HW; Yu, NW | 1 |
| Kanno, H; Kim, T; Kitawaki, J; Noguchi, T; Okada, H; Yamamoto, T | 1 |
| Brodie, A; Yue, W | 1 |
| Bajetta, E; Bichisao, E; Buzzoni, R; Celio, L; Noberasco, C; Zilembo, N | 1 |
| Höffken, K | 1 |
| Chiba, H; Saito, H; Shimizu, Y; Tohma, Y; Watanabe, S; Yanaihara, T | 1 |
| Aguado, LI; Carrizo, DG; Deis, RP; Rastrilla, AM; Stati, AO; Stocco, CO; Tellería, CM | 1 |
| Ekse, D; Lønning, PE | 1 |
| Enari, H; Ikeda, Y; Kashima, A; Kato, A; Konno, M; Niimura, K; Nitta, T; Sugita, N | 1 |
| Gaillard, JL; Moslemi, S; Silberzahn, P | 1 |
| Detre, S; Dowsett, M; Grimshaw, R; Lee, K; Macaulay, VM; Rowlands, M | 1 |
| Coombes, RC; Corbishley, C; Ford, HT; Gazet, JC; Griffin, M; Lowndes, S; Makinde, V; Quilliam, J; Sutcliffe, R | 1 |
| Block, JL; Block, NL; Lokeshwar, BL | 1 |
| Kobayashi, F; Smalley, KN; Zimniski, SJ | 1 |
| Goa, KL; Wiseman, LR | 1 |
| Boyle, T; Dukes, M; Edwards, PN; Large, M; Smith, IK | 1 |
| Brodie, A; Lu, Q; Nakamura, J; Savinov, A | 1 |
| Detre, S; Dowsett, M; Grimshaw, R; Rowlands, M | 1 |
| Frost, VJ; Helle, SI; Holly, JM; Lønning, PE; van der Stappen, JW | 1 |
| Almadhidi, J; Drosdowsky, MA; Moslemi, S; Séralini, GE | 1 |
| Anker, G; Geisler, J; Johannessen, DC; Lønning, PE | 1 |
| Brankin, E; Gallagher, A; Soukop, M | 1 |
| Rose, C | 1 |
| Cala, KM; Landrum, DP; Mahendroo, MS; Russell, DW | 1 |
| Bajetta, E; Bombardieri, E; Ferrari, L; Martinetti, A; Massaron, S; Noberasco, C; Rimassa, L; Seregni, E; Zilembo, N | 1 |
| Amichetti, M; Attili, A; Bajetta, E; Barni, S; Bichisao, E; Bolelli, GF; Bombardieri, E; Buzzoni, R; Comella, G; D'Aprile, M; Ferrari, L; Jirillo, A; Martinetti, A; Noberasco, C; Schieppati, G; Zilembo, N | 1 |
| Buzdar, AU; Roseman, BJ; Singletary, SE | 1 |
| Bonnefoi, H; Castiglione, M; Cavalli, F; Fey, MF; Goldhirsch, A; Hsu-Schmitz, SF; Löhnert, T; Morant, R; Thürlimann, B | 1 |
| Rubens, RD | 1 |
| Anderson, ED; Anderson, TJ; Cameron, DA; Chetty, U; Forrest, AP; Hawkins, RA; Leonard, RC; Levack, P | 1 |
| Aparicio, LA; Carrion, RP; Dodwell, DJ; Dowsett, M; Kleeberg, UR; Robertson, JF; Vorobiof, DA | 1 |
| Bruder, JM; Oettel, M; Sobek, L | 1 |
| Petrini, S; Zaccanti, F | 1 |
| Harada, N; Hatano, O | 1 |
| Moslemi, S; Seralini, GE | 1 |
| Burrello, N; Calogero, AE; D'Agata, R; Ossino, AM; Polosa, P | 1 |
| Dickson, RB; El-Ashry, D; Hannum, RS; Kern, FG; Kharbanda, S; Lopez, CA; Lorant, LA; McLeskey, SW; Tobias, CA; Trock, BJ; Zhang, L | 1 |
| Giussani, DA; Guller, S; Jenkins, SL; Nathanielsz, PW; Tame, JD; Winter, JA | 1 |
| Lønning, PE | 1 |
| Alonso, MC; Español, I; Muñíz-Díaz, E; Pujol-Moix, N | 1 |
| Danza, G; Guarna, A; Muratori, M; Occhiato, EG; Sadri, R; Serio, M | 1 |
| Brodie, AM; Grigoryev, DN; Long, BJ; Thiantanawat, A; Tilghman, SL; Yue, W | 1 |
| Anker, GB; Johannessen, DC; Lien, EA; Lonning, PE; Refsum, H; Ueland, PM | 1 |
| Andrés, E; Dufour, P; Goichot, B; Imler, M; Kurtz, JE; Schlienger, JL | 1 |
| Brodie, AM; Dehal, SS; Kupfer, D | 1 |
| Blijham, GH; de Jong, PC | 1 |
| Coombes, RC; Harper-Wynne, C | 1 |
| Coombes, RC; Doody, D; Dowsett, M; English, J; Howes, A; Miall, S | 1 |
| Bernhard, J; Bonnefoi, H; Castiglione-Gertsch, M; Cavalli, F; Fey, MF; Goldhirsch, A; Hürny, C; Morant, R; Schmitz, SF; Thürlimann, B | 2 |
| Bonneterre, J; Feutrie, ML | 1 |
| Calvo, L; Clack, G; Dodwell, DJ; Dowsett, M; Kleeberg, UR; Perez-Carrion, R; Robertson, JF; Vorobiof, DA | 1 |
| de Fougerolles Nunn, E; Greenstein, B; Hughes, GR; Khamashta, M | 1 |
| Brandi, ML; Fiorelli, G; Martineti, V; Picariello, L; Tonelli, F | 1 |
| Brodie, AM; Njar, VC | 1 |
| Coombes, RC; Dowsett, M; Harper-Wynne, C | 1 |
| Harvey, HA; Santen, RJ | 1 |
| Bajetta, E; Bichisao, E; Pozzi, P; Toffolatti, L; Zilembo, N | 1 |
| Joseph, JK; Lim, AK | 1 |
| Bland, KI; Chaudry, IH; Cioffi, WG; Nickel, EA; Samy, TS; Schneider, CP; Schwacha, MG | 1 |
| Audisio, RA; Castiglione, F; Comandini, D; Granetto, C; Repetto, L; Ross, R; Venturino, A | 1 |
| Damien, E; Lanyon, LE; Price, JS | 1 |
| Brunner-Ferber, F; Chavassieux, P; Delmas, PD; Duboeuf, F; Garnero, P; Meunier, PJ; Vergnaud, P | 1 |
| Bajetta, E; Bombardieri, E; Celio, L; Di Bartolomeo, M; Ferrari, L; Mariani, L; Martinetti, A; Miceli, R; Pozzi, P; Seregni, E; Toffolatti, L; Zilembo, N | 1 |
| Klinga, K; Mayer, D; Morfin, R; Schmitt, M; Schnarr, B | 1 |
| Chen, Q; Chihara, K; Kaji, H; Sugimoto, T | 1 |
| Bonneterre, J; Mauriac, L | 1 |
| Auvray, P; Bichat, F; Genne, P | 1 |
| de Crémoux, P | 1 |
| Kerbrat, P; Lefeuvre, C | 1 |
| Blum, W; Faigle, JW; Galli, B; Geisler, J; Gschwind, HP; Johannessen, DC; Kriemler, HP; Lønning, PE; Miller, WR; Schneider, W; Waldmeier, F; Winkler, T | 1 |
| Coombes, RC; Ford, HT; Gazet, JC; Gray, R; Lowndes, S; Makinde, V; McConkey, C; Quilliam, J; Sutcliffe, R | 1 |
| Buzdar, A; Howell, A | 1 |
| Goh, VH; Tong, TY | 1 |
| Carlini, P; Casali, A; Cognetti, F; De Marco, S; Fabi, A; Frassoldati, A; Nardi, M; Paoloni, F; Papaldo, P; Ruggeri, EM | 1 |
| Andrade, LC; da Silva, EJ; de Almeida, MJ; Neves, AS; Paixão, JA; Roleira, FM; Sá e Melo, ML; Silva, MR | 1 |
| Lombardi, P | 1 |
| Jiang, Z; Liu, X; Song, S; Wang, T; Wu, S; Yu, J | 1 |
| Alfaidy, N; Challis, JR; Gibb, W; Gupta, S; Holloway, AC; Lye, SJ; Whittle, WL | 1 |
| Ichikawa, Y; Miura, I; Ohtani, H | 1 |
| Bland, KI; Chaudry, IH; Samy, TS; Schneider, CP; Schwacha, MG | 1 |
| Briand, P; Jensen, J; Kitlen, JW; Labrie, F; Lykkesfeldt, AE | 1 |
| Burton, G; Kleeberg, U; Mauriac, L; Osborne, CK; Robertson, JF; Vergote, I | 1 |
| Cegieła, U; Folwarczna, J; Janiec, W; Kaczmarczyk-Sedlak, I; Nowińska, B; Pytlik, M; Woźnica, H | 1 |
| Carlini, P; Cognetti, F; Colella, E; Di Cosimo, S; Fabi, A; Ferretti, G; Frassoldati, A; Papaldo, P; Romiti, A; Ruggeri, EM; Tomao, S; Tonachella, R | 1 |
| Alt, JJ; Amateau, SK; McCarthy, MM; Stamps, CL | 1 |
| Bajetta, E; Bichisao, E; Bidoli, P; Bombardieri, E; La Torre, I; Longarini, R; Martinetti, A; Portale, T; Seregni, E; Zilembo, N | 1 |
| Delozier, T; Khayat, D; Spano, JP | 1 |
| Bria, E; Carlini, P; Cognetti, F; Di Cosimo, S; Fabi, A; Felici, A; Ferretti, G; Giannarelli, D; Milella, M; Mottolese, M; Nisticò, C; Papaldo, P; Ruggeri, EM; Terzoli, E | 1 |
| Andrews, S; Braun, DP; Crist, KA; Parker, J; Shaheen, F; Staren, ED | 1 |
| Cernich, J; Jacobson, JD; Moore, WV; Popovic, J | 1 |
| Ioannidis, JP; Mauri, D; Pavlidis, N; Polyzos, NP | 1 |
| Prosperi, JR; Robertson, FM | 1 |
| Sakai, T; Sakata, I; Tanaka, T; Tanizaki, T; Yamazaki, M; Zheng, Z | 1 |
| Chen, S; Wang, X | 1 |
| Kohler, M; Marner, FJ; Opfermann, G; Parr, MK; Schänzer, W; Schlörer, N; Thevis, M | 1 |
| Freudenstein, J; Nisslein, T | 1 |
| Cruz-Martínez, JJ; Fernández-Guasti, A; Márquez-Baltazar, S; Martínez-Mota, L | 1 |
| Fox, J; Hamad, A; Kluk, M; Park, M; Turner, JE | 1 |
| Dutta, U; Pant, K | 1 |
| Cavaliere, C; Ciardiello, F; Corvigno, S; Criniti, V; De Placido, S; Limite, G; Nardone, A; Picarelli, S; Tortora, G; Veneziani, BM | 1 |
| Barbosa, IR; Nogueira, AJ; Soares, AM | 1 |
| Allgood, OE; Bopp, KC; Henriet, RP; Holt, AW; Houser, AP; Nelson, BP; Turner, JE | 1 |
| Abrams, DN; Joshua, AV; McEwan, AJ; Sharma, SK; Zheng, W | 1 |
| McCarthy, MM; Nuñez, JL | 1 |
| Cawley, AT; George, AV; Kazlauskas, R; Trout, GJ | 1 |
| Contreras, CM; Gutiérrez-García, AG; Jacome-Jacome, E; Molina-Jiménez, T; Vásquez-Hernández, DI | 1 |
| Cravatt, BF; Song, JD; Wright, AT | 1 |
| Csákvári, E; Gyenes, A; Hoyk, Z; Kóti, J; Paragi, G; Párducz, A; Pfoh, R; Rühl, S; Szájli, A; Wölfling, J | 1 |
| Cavaliere, C; Corvigno, S; Galgani, M; Limite, G; Nardone, A; Veneziani, BM | 1 |
| Chen, CF; Chen, LR; Chen, YL; Lin, YP; Liou, JF; Shiue, YL; Yang, JR | 1 |
| Emery, C; Fusshöller, G; Piper, T; Saugy, M; Schänzer, W | 1 |
| Cheng, FX; Fu, J; Li, WH; Liu, GX; Shen, ZH; Tang, Y | 1 |
| Kwok, WH; Lam, KK; Leung, GN; Schiff, PJ; Wan, TS | 1 |
| Aceves-Ramos, A; Gaona, B; Romano, MC; Valdez, RA; Willms, K | 1 |
| Chakraborti, A; Gulati, K; Ray, A | 2 |
| Polet, M; Van Eenoo, P; Van Gansbeke, W; Van Renterghem, P | 1 |
| Marti, A; Martin, GD; Narvaez, J | 1 |
| Baume, N; Dvorak, J; Emery, C; Giraud, S; Jan, N; Leuenberger, N; Mandanis, B; Marclay, F; Nicoli, R; Perrenoud, L; Robinson, N; Saugy, M; Schweizer, C | 1 |
| Ibrahim, H; Ibrahim, M; Kotb, M; Temerk, Y | 1 |
| Gramapurohit, NP; Mali, PV | 1 |
| Essers, ML; Kaklamanos, G; Meijer, T; Sterk, SS; van Ginkel, LA | 1 |
| Abderrahman, B; Jordan, VC | 1 |
| Bale, TL; Morgan, CP | 1 |
| Connaughton, VP; Gould, CJ; Wiegand, JL | 1 |
| Diel, P; Keiler, AM; Machalz, D; Parr, MK; Schänzer, W; Vollmer, G; Wolber, G; Wolf, S; Zierau, O | 1 |
| Connaughton, VP; Gould, CJ; Saldanha, CJ | 1 |
| Botrè, F; Colamonici, C; de la Torre, X; Martinez Brito, D; Parr, MK | 1 |
| Bao, Z; Deng, H; Gao, L; Li, J; Li, X; Liu, L; Nie, D; Rong, Z; Teichmann, AT; Wang, G; Wieland, FH; Yang, Y | 1 |
| Cheboub, A; Djidjik, R; Hadj-Bekkouche, F; Regouat, N; Slimani, A | 1 |
| Chen, Y; Kong, X; Tao, S; Teichmann, AT; Wan, R; Wieland, FH; Yang, Y | 1 |
| Hinchcliffe, JK; Mendl, M; Robinson, ESJ | 1 |
| Greenberg, DA; McCarthy, E; Miller, J; Morris Cameron, E; Pathak, S; Saint Ange, P; Shakil, F; Velíšek, L; Velíšková, J | 1 |
| Botrè, F; de la Torre, X; Kollmeier, AS; Müller, C; Parr, MK | 1 |
| Chan, KL; Khoo, BY; Khurshid Ahmed, NA; Lee, CY; Lim, SK; Pandian, GN; Sugiyama, H | 1 |
| El-Gowilly, SM; El-Mas, MM; Sallam, MY | 1 |
| Chen, Y; Gao, L; Huang, S; Li, H; Luo, Y; Teichmann, AT; Wu, Z; Zhang, L; Zou, L | 1 |
54 review(s) available for androstenedione and formestane
| Article | Year |
|---|---|
Mechanism and inhibition of cytochrome P-450 aromatase.
Topics: Affinity Labels; Aromatase; Aromatase Inhibitors; Binding, Competitive; Humans; Molecular Structure; Photochemistry | 1990 |
Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer.
Topics: Aromatase; Aromatase Inhibitors; Breast Neoplasms; Drug Design; Female; Humans; Models, Molecular; Molecular Structure | 2015 |
Aromatase inhibitors: clinical pharmacology and therapeutic implications in breast cancer.
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Imidazoles; Letrozole; Nitriles; Triazoles | 1992 |
Aromatization inhibition alone or in combination with GnRH agonists for the treatment of premenopausal breast cancer patients.
Topics: Androstenedione; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Buserelin; Estrogens; Female; Goserelin; Humans; Menopause | 1992 |
Exemestane (FCE 24304), a new steroidal aromatase inhibitor.
Topics: 5-alpha Reductase Inhibitors; Androgens; Androstadienes; Androstenedione; Animals; Antineoplastic Agents; Aromatase Inhibitors; Humans; Lyases; Receptors, Steroid | 1992 |
Inhibition of oestrogen synthesis in postmenopausal women with breast cancer.
Topics: Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Arylsulfatases; Breast Neoplasms; Danazol; Estrogens; Female; Humans; Kinetics; Menopause; Steryl-Sulfatase | 1992 |
Androgen metabolism in different target tissues.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Aging; Androstenedione; Animals; Brain; Cricetinae; Dihydrotestosterone; Humans; Male; Pituitary Gland; Prostate; Prostatic Hyperplasia; Rats; Testosterone | 1990 |
Aromatase and its inhibitors--an overview.
Topics: Androstenedione; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Humans | 1991 |
Postmenopausal estrogen synthesis and metabolism: alterations caused by aromatase inhibitors used for the treatment of breast cancer.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Fadrozole; Female; Humans; Imidazoles; Menopause; Nitriles | 1990 |
New trends in the endocrine treatment of breast cancer.
Topics: Androstenedione; Breast Neoplasms; Buserelin; Female; Goserelin; Humans; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen | 1990 |
Recent progress in development of aromatase inhibitors.
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Fadrozole; Humans; Imidazoles; Nitriles | 1990 |
Clinical development of aromatase inhibitors for the treatment of breast and prostate cancer.
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Design; Estrogen Antagonists; Fadrozole; Humans; Imidazoles; Nitriles | 1990 |
Aromatase inhibitors and hormone-dependent cancers.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Breast Neoplasms; Humans; Neoplasms, Hormone-Dependent | 1990 |
Aromatase and other inhibitors in breast and prostatic cancer.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Estrogen Antagonists; Humans; Male; Prostatic Neoplasms | 1990 |
Aromatase inhibitors: their biochemistry and clinical potential.
Topics: 17-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androstenedione; Animals; Aromatase Inhibitors; Breast Neoplasms; Chemical Phenomena; Chemistry; Estrogens; Female; Humans; Male; Oxidoreductases; Prostatic Hyperplasia | 1987 |
Aromatase inhibitors in the treatment of advanced breast cancer.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Imidazoles; Neoplasms, Hormone-Dependent; Nitriles | 1989 |
Clinical use of aromatase inhibitors in the treatment of breast cancer.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Estrogen Antagonists; Estrogens; Female; Humans | 1988 |
Aromatase in breast cancer and the role of aminoglutethimide and other aromatase inhibitors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Aged; Aminoglutethimide; Androgens; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Estrogens; Female; Humans; Mammary Neoplasms, Experimental; Metabolic Clearance Rate; Middle Aged; Rats; Tamoxifen | 1986 |
Aromatase and aromatase inhibitors: from enzymology to selective chemotherapy.
Topics: Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Neoplasms, Hormone-Dependent; Pargyline; Rats | 1988 |
Aromatase inhibitors: basic and clinical studies.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Female; Humans; In Vitro Techniques; Mammary Neoplasms, Experimental; Ovary | 1987 |
Enzymatic control of estrogen production in human breast cancer: relative significance of aromatase versus sulfatase pathways.
Topics: 17-Hydroxysteroid Dehydrogenases; Adrenalectomy; Aminoglutethimide; Androstenedione; Animals; Aromatase; Breast Neoplasms; Estradiol; Estrogens; Estrone; Female; Humans; Hydrocortisone; Mammary Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Rats; Sulfatases; Testolactone | 1986 |
Aromatase inhibition and its pharmacologic implications.
Topics: Androstatrienes; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Female; Humans; Kinetics; Macaca mulatta; Male; Mammary Neoplasms, Experimental; Menopause; Oligospermia; Oxidoreductases; Rats; Uterine Neoplasms | 1985 |
Formestane. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the management of breast cancer and prostatic cancer.
Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; In Vitro Techniques; Male; Prostatic Neoplasms | 1993 |
Management of benign prostatic hyperplasia with particular emphasis on aromatase inhibitors.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Estradiol; Humans; Male; Prostatic Hyperplasia; Tamoxifen | 1993 |
Aromatase and its inhibitors in breast cancer treatment--overview and perspective.
Topics: Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Steroids | 1994 |
The role of aromatase in breast tumors.
Topics: Androstenedione; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; DNA Polymerase II; Estrogens; Estrone; Female; Humans; Prognosis; Receptors, Progesterone; Tumor Cells, Cultured | 1994 |
Second generation aromatase inhibitor--4-hydroxyandrostenedione.
Topics: Administration, Oral; Adult; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Female; Humans; Injections, Intramuscular; Male | 1994 |
Aromatase, its inhibitors and their use in breast cancer treatment.
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Half-Life; Humans; Neoplasms, Hormone-Dependent; Pargyline | 1993 |
Formestane for advanced breast cancer in postmenopausal women.
Topics: Androstenedione; Antineoplastic Agents; Breast Neoplasms; Costs and Cost Analysis; Female; Humans; Injections, Intramuscular; Postmenopause | 1993 |
Experience with aromatase inhibitors in the treatment of advanced breast cancer.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Forecasting; Humans | 1993 |
The control and biological importance of intratumoural aromatase in breast cancer.
Topics: Adenocarcinoma; Androgens; Androstenedione; Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Male; Mice; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Nitriles; Triazoles; Tumor Cells, Cultured | 1996 |
Formestane. A review of its pharmacological properties and clinical efficacy in the treatment of postmenopausal breast cancer.
Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Female; Humans; Postmenopause; Rats | 1996 |
Proper sequence of endocrine therapies in advanced breast cancer.
Topics: Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Postmenopause; Premenopause | 1996 |
Use of aromatase inhibitors in postmenopausal women with advanced breast cancer.
Topics: Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Tamoxifen; Triazoles | 1997 |
Pharmacological profiles of exemestane and formestane, steroidal aromatase inhibitors used for treatment of postmenopausal breast cancer.
Topics: Androstadienes; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Neoplasms, Hormone-Dependent; Postmenopause | 1998 |
Aromatase inhibitors and their use in the adjuvant setting.
Topics: Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Enzyme Inhibitors; Fadrozole; Female; Humans | 1998 |
New aromatase inhibitors for the treatment of advanced breast cancer in postmenopausal women.
Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Megestrol Acetate; Nitriles; Postmenopause; Triazoles | 1999 |
[Aromatase inhibitors].
Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Estrogen Antagonists; Estrone; Female; Humans; Letrozole; Nitriles; Triazoles | 1999 |
Aromatase inhibitors and their application in breast cancer treatment*.
Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Mice; Nitriles; Tamoxifen; Triazoles | 2000 |
Drug and hormone interactions of aromatase inhibitors.
Topics: Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Interactions; Enzyme Inhibitors; Estrogens; Fadrozole; Female; Humans; Letrozole; Male; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Premenopause; Sensitivity and Specificity; Tamoxifen; Triazoles | 1999 |
Aromatase inhibitors and their use in the sequential setting.
Topics: Androstenedione; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Triazoles | 1999 |
Use of aromatase inhibitors in breast carcinoma.
Topics: Adult; Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Drug Design; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Middle Aged; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Premenopause; Tamoxifen; Triazoles | 1999 |
Steroidal aromatase inhibitors in elderly patients.
Topics: Aged; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Triazoles | 2000 |
[Preclinical evaluation of aromatase inhibitors antitumor activity].
Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fadrozole; Female; Humans; Letrozole; Models, Animal; Nitriles; Rats; Structure-Activity Relationship; Triazoles | 2000 |
[Aromatase inhibitors: pharmacological aspects].
Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Enzyme Inhibitors; Fadrozole; Female; Humans; Letrozole; Nitriles; Triazoles | 2000 |
[Aromatase inhibitors: a review of clinical trials].
Topics: Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Triazoles | 2000 |
Advances in aromatase inhibition: clinical efficacy and tolerability in the treatment of breast cancer.
Topics: Anastrozole; Androstadienes; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Fadrozole; Female; Headache; Humans; Letrozole; Nausea; Nitriles; Treatment Outcome; Triazoles; Vomiting | 2001 |
Exemestane, a new steroidal aromatase inhibitor of clinical relevance.
Topics: Androstadienes; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogen Receptor Modulators; Estrogens; Female; Humans; Neoplasms, Hormone-Dependent | 2002 |
[Aromatase inhibitors in adjuvant setting in breast cancer].
Topics: Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Menopause; Nitriles; Triazoles | 2004 |
New aromatase inhibitors as second-line endocrine therapy in postmenopausal patients with metastatic breast carcinoma: a pooled analysis of the randomized trials.
Topics: Aged; Anastrozole; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Clinical Trials, Phase III as Topic; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Fadrozole; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Probability; Prognosis; Remission Induction; Risk Assessment; Survival Analysis; Triazoles | 2005 |
Use of aromatase inhibitors in children with short stature.
Topics: Adult; Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Body Height; Child; Estrogens; Female; Growth Disorders; Humans; Letrozole; Male; Musculoskeletal System; Nitriles; Triazoles | 2004 |
Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis.
Topics: Adult; Aged; Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Odds Ratio; Randomized Controlled Trials as Topic; Survival Analysis; Triazoles | 2006 |
Aromatase inhibitors: past, present and future in breast cancer therapy.
Topics: Aminoglutethimide; Androstadienes; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Fadrozole; Female; Humans; Letrozole; Nitriles; Triazoles | 2008 |
[Progress in study of the structure, catalytic mechanism and inhibitors of aromatase].
Topics: Androstenedione; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Catalysis; Coumarins; Estrogens; Flavonoids; Humans; Inhibitory Concentration 50; Letrozole; Nitriles; Sesquiterpenes; Structure-Activity Relationship; Triazoles; Xanthones | 2012 |
37 trial(s) available for androstenedione and formestane
| Article | Year |
|---|---|
4-hydroxyandrostenedione: a new treatment for postmenopausal patients with breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Drug Evaluation; Estradiol; Female; Humans; Injections, Intramuscular; Menopause; Middle Aged; Time Factors | 1992 |
Influence of aminoglutethimide on plasma oestrogen levels in breast cancer patients on 4-hydroxyandrostenedione treatment.
Topics: Adult; Aged; Aged, 80 and over; Aminoglutethimide; Androstenedione; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Female; Humans; Middle Aged; Pilot Projects | 1992 |
Exemestane (FCE 24304), a new steroidal aromatase inhibitor.
Topics: 5-alpha Reductase Inhibitors; Androgens; Androstadienes; Androstenedione; Animals; Antineoplastic Agents; Aromatase Inhibitors; Humans; Lyases; Receptors, Steroid | 1992 |
An endocrine and pharmacokinetic study of four oral doses of formestane in postmenopausal breast cancer patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Estradiol; Female; Humans; Menopause; Middle Aged | 1992 |
Aromatase inhibition: 4-hydroxyandrostenedione (4-OHA, CGP 32349) in advanced prostatic cancer.
Topics: Aged; Androstenedione; Aromatase Inhibitors; Dihydrotestosterone; Estradiol; Humans; Male; Neoplasm Staging; Prostatic Neoplasms; Testosterone; Time Factors | 1992 |
Randomised trial of chemotherapy versus endocrine therapy in patients presenting with locally advanced breast cancer (a pilot study).
Topics: Adult; Aged; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Buserelin; Female; Goserelin; Humans; Immunohistochemistry; Middle Aged; Neoplasm Staging; Pilot Projects; Receptors, Estrogen | 1991 |
Primary systemic therapy for operable breast cancer.
Topics: Adult; Aged; Aminoglutethimide; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Buserelin; Combined Modality Therapy; Female; Goserelin; Humans; Lymphatic Metastasis; Middle Aged; Ovariectomy; Tamoxifen | 1991 |
The clinical and endocrine effects of 4-hydroxyandrostenedione alone and in combination with goserelin in premenopausal women with advanced breast cancer.
Topics: Adult; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Buserelin; Female; Goserelin; Humans; Menopause; Middle Aged; Ovariectomy | 1990 |
New trends in the endocrine treatment of breast cancer.
Topics: Androstenedione; Breast Neoplasms; Buserelin; Female; Goserelin; Humans; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen | 1990 |
Aromatase inhibition with 4-hydroxyandrostenedione in the treatment of postmenopausal patients with advanced breast cancer: a phase II study.
Topics: Adult; Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Evaluation; Estradiol; Female; Germany, West; Humans; Life Tables; Menopause; Middle Aged; Multicenter Studies as Topic; Receptors, Estrogen; Remission Induction; Tamoxifen | 1990 |
Aromatase inhibition in advanced prostatic cancer: preliminary communication.
Topics: Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Clinical Trials as Topic; Humans; Male; Middle Aged; Prostatic Neoplasms | 1990 |
Dose-related endocrine effects and pharmacokinetics of oral and intramuscular 4-hydroxyandrostenedione in postmenopausal breast cancer patients.
Topics: Administration, Oral; Androstenedione; Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Estrone; Female; Half-Life; Humans; Injections, Intramuscular; Menopause; Sex Hormone-Binding Globulin | 1989 |
Aromatase in breast cancer and the role of aminoglutethimide and other aromatase inhibitors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Aged; Aminoglutethimide; Androgens; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Estrogens; Female; Humans; Mammary Neoplasms, Experimental; Metabolic Clearance Rate; Middle Aged; Rats; Tamoxifen | 1986 |
Aromatase inhibition with 4-OHAndrostenedione after prior aromatase inhibition with aminoglutethimide in women with advanced breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Aminoglutethimide; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Female; Humans; Middle Aged; Neoplasm Staging; Ovariectomy; Postmenopause | 1995 |
The effects of oral 4-hydroxyandrostenedione on peripheral aromatisation in post-menopausal breast cancer patients.
Topics: Administration, Oral; Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Female; Humans; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Postmenopause | 1995 |
Formestane: effective therapy in postmenopausal women with advanced breast cancer.
Topics: 17-Hydroxycorticosteroids; Aged; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Estradiol; Female; Humans; Middle Aged; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Postmenopause; Receptors, Estrogen | 1994 |
Comparison of the selective aromatase inhibitor formestane with tamoxifen as first-line hormonal therapy in postmenopausal women with advanced breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Middle Aged; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Postmenopause; Receptors, Estrogen; Survival Analysis; Tamoxifen | 1994 |
Formestane in the treatment of advanced postmenopausal breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Female; Humans; Injections, Intramuscular; Middle Aged; Neoplasm Metastasis; Postmenopause; Remission Induction | 1994 |
Formestane as treatment of advanced breast cancer in elderly women.
Topics: Aged; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Prognosis; Risk Factors; Treatment Outcome | 1994 |
Effect of two-4-hydroxyandrostenedione doses on serum insulin-like growth factor I levels in advanced breast cancer.
Topics: Aged; Androstenedione; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Insulin-Like Growth Factor I; Middle Aged; Neoplasm Metastasis; Postmenopause; Time Factors | 1994 |
Endocrinological and clinical evaluation of two doses of formestane in advanced breast cancer.
Topics: 17-Hydroxycorticosteroids; Aged; Analysis of Variance; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chi-Square Distribution; Estradiol; Female; Humans; Hydrocortisone; Middle Aged; Receptors, Estrogen; Remission Induction; Treatment Outcome | 1994 |
Treatment with formestane alone and in combination with aminoglutethimide in heavily pretreated breast cancer patients: clinical and endocrine effects.
Topics: Adult; Aged; Aged, 80 and over; Aminoglutethimide; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Female; Humans; Middle Aged | 1996 |
A multicentre, randomized, pharmacokinetic, endocrine and clinical study to evaluate formestane in breast cancer patients at first relapse: endocrine and clinical results. The Italian Trials in Medical Oncology (I.T.M.O.) group.
Topics: Adult; Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Estrone; Female; Humans; Injections, Intramuscular; Middle Aged; Postmenopause; Survival Analysis; Treatment Outcome | 1997 |
Formestane versus megestrol acetate in postmenopausal breast cancer patients after failure of tamoxifen: a phase III prospective randomised cross over trial of second-line hormonal treatment (SAKK 20/90). Swiss Group for Clinical Cancer Research (SAKK)
Topics: Adult; Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cross-Over Studies; Female; Humans; Megestrol Acetate; Middle Aged; Neoplasm Metastasis; Postmenopause; Prospective Studies; Receptors, Estrogen; Regression Analysis; Remission Induction; Tamoxifen; Time Factors; Treatment Failure | 1997 |
Primary systemic therapy for operable breast cancer--10-year survival data after chemotherapy and hormone therapy.
Topics: Adult; Aged; Aminoglutethimide; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Axilla; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Goserelin; Humans; Hydrocortisone; Lymphatic Metastasis; Middle Aged; Neoplasms, Hormone-Dependent; Ovariectomy; Prednisone; Preoperative Care; Tamoxifen; Treatment Outcome; Vincristine | 1997 |
A randomised comparison of oestrogen suppression with anastrozole and formestane in postmenopausal patients with advanced breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estradiol; Female; Humans; Middle Aged; Nitriles; Postmenopause; Treatment Outcome; Triazoles | 1997 |
Anastrozole shows evidence of activity in postmenopausal patients who have responded or stabilised on formestane therapy.
Topics: Anastrozole; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Disease Progression; Female; Humans; Nitriles; Postmenopause; Prospective Studies; Receptors, Estrogen; Treatment Outcome; Triazoles | 1999 |
Vorozole results in greater oestrogen suppression than formestane in postmenopausal women and when added to goserelin in premenopausal women with advanced breast cancer.
Topics: Adult; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Estradiol; Female; Goserelin; Humans; Middle Aged; Ovary; Postmenopause; Premenopause; Triazoles | 1999 |
Quality of life in postmenopausal patients with breast cancer after failure of tamoxifen: formestane versus megestrol acetate as second-line hormonal treatment. Swiss Group for Clinical Cancer Research (SAKK).
Topics: Adaptation, Psychological; Adult; Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Megestrol Acetate; Middle Aged; Quality of Life; Tamoxifen; Treatment Failure | 1999 |
Defining clinical benefit in postmenopausal patients with breast cancer under second-line endocrine treatment: does quality of life matter?
Topics: Adult; Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Breast Neoplasms; Disease-Free Survival; Female; Health Status; Humans; Megestrol Acetate; Middle Aged; Postmenopause; Quality of Life; Statistics as Topic; Treatment Outcome | 1999 |
A randomized, open, parallel-group trial to compare the endocrine effects of oral anastrozole (Arimidex) with intramuscular formestane in postmenopausal women with advanced breast cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anastrozole; Androstenedione; Antineoplastic Agents; Breast Neoplasms; Estrogens; Female; Humans; Injections, Intramuscular; Middle Aged; Nitriles; Triazoles | 1999 |
The luteinising hormone-releasing hormone analogue triptorelin with or without the aromatase inhibitor formestane in premenopausal breast cancer: effects on bone metabolism markers.
Topics: Adult; Androstenedione; Aromatase Inhibitors; Biomarkers; Bone and Bones; Breast Neoplasms; Estradiol; Female; Gonadotropin-Releasing Hormone; Growth Substances; Humans; Interleukin-6; Middle Aged; Premenopause; Statistics, Nonparametric; Triptorelin Pamoate | 2000 |
Estrogen-receptor-directed neoadjuvant therapy for breast cancer: results of a randomised trial using formestane and methotrexate, mitozantrone and mitomycin C (MMM) chemotherapy.
Topics: Adult; Aged; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Goserelin; Humans; Methotrexate; Middle Aged; Mitomycin; Mitoxantrone; Neoadjuvant Therapy; Neoplasm Metastasis; Postmenopause; Premenopause; Prognosis; Receptors, Estrogen; Survival Analysis | 2001 |
[Clinical trial of lentaron for postmenopausal patients with advanced breast cancer].
Topics: Androstenedione; Antineoplastic Agents; Breast Neoplasms; Disease Progression; Female; Humans; Neoplasm Metastasis; Neoplasm Staging; Postmenopause; Treatment Outcome | 2002 |
Postmenopausal women who progress on fulvestrant ('Faslodex') remain sensitive to further endocrine therapy.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Disease Progression; Double-Blind Method; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estradiol; Estrogen Receptor Modulators; Female; Follow-Up Studies; Fulvestrant; Humans; Letrozole; Megestrol Acetate; Middle Aged; Nitriles; Postmenopause; Retrospective Studies; Salvage Therapy; Treatment Outcome; Triazoles | 2003 |
Is there a benefit by the sequence anastrozole-formestane for postmenopausal metastatic breast cancer women?
Topics: Adult; Aged; Anastrozole; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Middle Aged; Neoplasm Metastasis; Nitriles; Postmenopause; Receptors, Estrogen; Tamoxifen; Triazoles | 2003 |
The estrogen suppression after sequential treatment with formestane in advanced breast cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Estrogen Antagonists; Female; Humans; Injections, Intramuscular; Middle Aged; Postmenopause; Receptors, Estradiol | 2004 |
234 other study(ies) available for androstenedione and formestane
| Article | Year |
|---|---|
Interactions of thiol-containing androgens with human placental aromatase.
Topics: Androstenedione; Aromatase Inhibitors; Chemical Phenomena; Chemistry; Drug Interactions; Female; Humans; In Vitro Techniques; Microsomes; Paraoxon; Placenta; Pregnancy; Structure-Activity Relationship; Sulfhydryl Compounds; Testosterone Congeners | 1989 |
Molecular determinants of steroid inhibition for the mouse constitutive androstane receptor.
Topics: Animals; Cell Line; Constitutive Androstane Receptor; Histone Acetyltransferases; Humans; Mice; Models, Molecular; Mutation; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Coactivator 1; Protein Structure, Secondary; Quantitative Structure-Activity Relationship; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Repressor Proteins; Steroids; Transcription Factors; Two-Hybrid System Techniques; Yeasts | 2003 |
Structure-activity relationships of new A,D-ring modified steroids as aromatase inhibitors: design, synthesis, and biological activity evaluation.
Topics: Androstanes; Androstenedione; Aromatase Inhibitors; Cyclopentanes; Drug Design; Humans; In Vitro Techniques; Lactones; Microsomes; Placenta; Stereoisomerism; Structure-Activity Relationship | 2005 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
The effect of an aromatase inhibitor, 4-hydroxy-4-androstene-3,17-dione, on estrogen-dependent processes in reproduction and breast cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androstenedione; Animals; Aromatase Inhibitors; Body Weight; Embryo Implantation; Estrogens; Female; Humans; Male; Mammary Neoplasms, Experimental; Pregnancy; Proestrus; Rats | 1977 |
Effects of 4-hydroxyandrost-4-ene-3,17-dione and its metabolites on 5 alpha-reductase activity and the androgen receptor.
Topics: 5-alpha Reductase Inhibitors; Androgen Receptor Antagonists; Androstenedione; Animals; Cytosol; Humans; Hydrogen-Ion Concentration; Hydroxytestosterones; Kinetics; Male; Nandrolone; Prostate; Rats; Rats, Wistar; Receptors, Androgen; Structure-Activity Relationship | 1992 |
The effect of endocrine therapy with medroxyprogesterone acetate, 4-hydroxyandrostenedione or tamoxifen on plasma concentrations of insulin-like growth factor (IGF)-I, IGF-II and IGFBP-1 in women with advanced breast cancer.
Topics: Aged; Androstenedione; Breast Neoplasms; Carrier Proteins; Female; Humans; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Medroxyprogesterone; Medroxyprogesterone Acetate; Neoplasms, Hormone-Dependent; Tamoxifen | 1992 |
Disruption of ovarian development in alligator embryos treated with an aromatase inhibitor.
Topics: Alligators and Crocodiles; Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Cyproterone; Cyproterone Acetate; Estradiol; Fadrozole; Female; Imidazoles; Male; Nitriles; Ovary; Tamoxifen; Testis | 1992 |
The influence of intramuscular 4-hydroxyandrostenedione on peripheral aromatisation in breast cancer patients.
Topics: Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Estriol; Estrone; Female; Humans; Injections, Intramuscular; Middle Aged | 1992 |
In vitro potency and selectivity of the non-steroidal androgen aromatase inhibitor CGS 16949A compared to steroidal inhibitors in the brain.
Topics: Androstatrienes; Androstenedione; Animals; Aromatase Inhibitors; Birds; Fadrozole; Gerbillinae; Hypothalamus; In Vitro Techniques; Kinetics; Male; Testosterone | 1992 |
Identification of 4-hydroxyandrost-4-ene-3,17-dione metabolites in prostatic cancer patients by liquid chromatography-mass spectrometry.
Topics: Androstenedione; Chromatography, High Pressure Liquid; Humans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Prostatic Neoplasms; Spectrophotometry, Ultraviolet | 1992 |
Aromatase inhibitors regenerate the thymus in aging male rats.
Topics: Aging; Androstatrienes; Androstenedione; Animals; Aromatase Inhibitors; Male; Rats; Rats, Inbred Strains; Receptors, Estrogen; Regeneration; Thymus Gland | 1992 |
4-Hydroxyandrostenedione treatment for postmenopausal patients with breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Female; Humans; Menopause; Middle Aged | 1992 |
Effect of the aromatase inhibitor, 4 hydroxyandrostenedione, on the endotoxin-induced changes in steroid hormones in male rats.
Topics: Analysis of Variance; Androstenedione; Animals; Aromatase Inhibitors; Corticosterone; Endotoxins; Escherichia coli; Gas Chromatography-Mass Spectrometry; Gonadal Steroid Hormones; Male; Progestins; Radioimmunoassay; Rats; Rats, Inbred Strains | 1992 |
Selective inhibition of the 5 alpha-reductase of the rat epididymis.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Androstenedione; Animals; Azasteroids; Dihydrotestosterone; Epididymis; In Vitro Techniques; Male; Molecular Structure; Pyrazoles; Rats; Rats, Inbred Strains; Steroids | 1992 |
Estrogens and benign prostatic hyperplasia: rationale for therapy with aromatase inhibitors.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Estrogens; Humans; Male; Prostatic Hyperplasia | 1991 |
Selection of 19-(ethyldithio)-androst-4-ene-3,17-dione (ORG 30958): a potent aromatase inhibitor in vivo.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dogs; Estradiol; Estrus; Female; Gonadotropins, Equine; Humans; In Vitro Techniques; Male; Ovariectomy; Ovary; Ovulation; Rats; Rats, Inbred Strains; Testosterone | 1991 |
Determination of 4-hydroxyandrostenedione in plasma and urine by extractive alkylation and electron-capture gas chromatography.
Topics: Alkylation; Androstenedione; Calibration; Chromatography, Gas; Humans | 1991 |
Determination of 4-hydroxyandrost-4-ene-3,17-dione metabolism in breast cancer patients using high-performance liquid chromatography-mass spectrometry.
Topics: Administration, Oral; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Chromatography, High Pressure Liquid; Female; Humans; Mass Spectrometry | 1991 |
4-Hydroxyandrostenedione in the prophylaxis of N-methyl-N-nitrosourea induced mammary tumourigenesis.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Random Allocation; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Concentrations of oestrone and 4-hydroxyandrostenedione in malignant and normal breast tissues.
Topics: Aged; Androstenedione; Aromatase Inhibitors; Breast; Breast Neoplasms; DNA Polymerase II; Estrone; Female; Humans; Neoplasm Staging | 1991 |
The use of rat Leydig tumor (R2C) and human hepatoma (HEPG2) cells to evaluate potential inhibitors of rat and human steroid aromatase.
Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase Inhibitors; Carcinoma, Hepatocellular; Cell Line; Drug Screening Assays, Antitumor; Humans; Kinetics; Leydig Cell Tumor; Liver Neoplasms; Male; Pargyline; Rats; Testicular Neoplasms | 1990 |
Effect of estrogen inhibitors on conceptus estrogen synthesis and development in the gilt.
Topics: Acid Phosphatase; Androstenedione; Animals; Aromatase Inhibitors; Blastocyst; Calcium; Clomiphene; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Embryonic and Fetal Development; Estrogen Antagonists; Estrogens; Female; Least-Squares Analysis; Piperidines; Pregnancy; Pregnancy Proteins; Pregnancy, Animal; Pyrimidines; Raloxifene Hydrochloride; Swine | 1991 |
Effect of the aromatase inhibitor 4-hydroxyandrostene-3,17-dione progesterone synthesis by human luteal cells.
Topics: 20-alpha-Dihydroprogesterone; Adult; Androstenedione; Aromatase Inhibitors; Cells, Cultured; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Estradiol; Female; Humans; Luteal Cells; Pregnenolone; Progesterone; Testosterone | 1991 |
[Estrogen formation in the central nervous system and characteristics of aromatase of rat hypothalamus].
Topics: Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Culture Techniques; Dose-Response Relationship, Drug; Estrogens; Gas Chromatography-Mass Spectrometry; Humans; Hypothalamus; Male; Placenta; Rats; Rats, Inbred Strains | 1991 |
Effect of 4-hydroxyandrostenedione on murine Leydig tumor cell steroidogenesis.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Leydig Cell Tumor; Male; Mice; Pargyline; Pregnenolone; Progesterone; Testosterone | 1991 |
Comparison of the pharmacokinetics and pharmacodynamics of unformulated and formulated 4-hydroxyandrostenedione taken orally by healthy men.
Topics: Adult; Androstenedione; Aromatase Inhibitors; Biological Availability; Estradiol; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Metabolic Clearance Rate; Powders; Random Allocation; Solutions; Testosterone | 1990 |
Reversible inhibition of human placental microsomal aromatase by CGS 18320B and other non-steroidal compounds.
Topics: Androstenedione; Aromatase Inhibitors; Binding Sites; Binding, Competitive; Fadrozole; Female; Glutethimide; Humans; Imidazoles; Kinetics; Microsomes; Molecular Structure; Nitriles; Placenta; Pregnancy | 1990 |
Analysis by DNA polymerase alpha activity of human breast tumour proliferation and the effect of endocrine therapy.
Topics: Androstenedione; Antineoplastic Agents; Biopsy; Breast Neoplasms; DNA Polymerase II; Estrogens; Female; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Neoplasms, Hormone-Dependent; Receptors, Estrogen | 1990 |
Endocrine and clinical aspects of new compounds for treatment of hormone-related cancer in gynecology.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Buserelin; Female; Goserelin; Humans; Neoplasms, Hormone-Dependent; Tamoxifen | 1990 |
Aromatization mediates aggressive behavior in quail.
Topics: 5-alpha Reductase Inhibitors; Aggression; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Azasteroids; Behavior, Animal; Coturnix; Dihydrotestosterone; Estradiol; Female; Flutamide; Hypothalamus; Male; Motor Activity; Nitromifene; Preoptic Area; Quail; Testosterone | 1990 |
Stable expression of human aromatase complementary DNA in mammalian cells: a useful system for aromatase inhibitor screening.
Topics: Aminoglutethimide; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Base Sequence; Blotting, Southern; Cricetinae; Cricetulus; DNA; Female; Gene Expression; Humans; Kinetics; Molecular Sequence Data; Ovary; Placenta; Plasmids; Polymerase Chain Reaction; Pregnancy; Transfection; Tumor Cells, Cultured | 1990 |
Serum kinetics of the anti-cancer agent 4-hydroxyandrostenedione in the rat.
Topics: Androstenedione; Animals; Antineoplastic Agents; Female; Male; Radioimmunoassay; Rats; Rats, Inbred Strains; Sex Factors | 1990 |
The inhibition of human prostatic aromatase activity by imidazole drugs including ketoconazole and 4-hydroxyandrostenedione.
Topics: Androstenedione; Aromatase Inhibitors; Estradiol; Estrone; Humans; Imidazoles; Ketoconazole; Male; Prostate; Structure-Activity Relationship | 1990 |
4-Aminoandrostenedione derivatives: a novel class of irreversible aromatase inhibitors. Comparison with FCE 24304 and 4-hydroxyandrostenedione.
Topics: Androstadienes; Androstenedione; Animals; Aromatase Inhibitors; Female; Male; Pregnancy; Rats; Rats, Inbred Strains | 1990 |
Distribution and cyclic change of aromatase cytochrome P-450 activity in human uteri.
Topics: Adult; Androstenedione; Aromatase; Cervix Uteri; Endometrium; Epithelium; Female; Humans; Menstrual Cycle; Middle Aged; Protein Conformation; Uterus | 1990 |
Effect of treatment with 4-hydroxyandrostenedione on the peripheral conversion of androstenedione to estrone and in vitro tumor aromatase activity in postmenopausal women with breast cancer.
Topics: Aged; Androstenedione; Antineoplastic Agents; Aromatase; Breast Neoplasms; DNA Polymerase II; Estrone; Female; Humans; Kinetics; Metabolic Clearance Rate | 1990 |
Treatment of advanced breast cancer in postmenopausal women with 4-hydroxyandrostenedione.
Topics: Adult; Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Estradiol; Female; Humans; Menopause; Middle Aged | 1990 |
Radioimmunoassay of the anti-cancer agent 4-hydroxyandrostenedione in body fluids.
Topics: Androstenedione; Antineoplastic Agents; Blood Proteins; Body Fluids; Gas Chromatography-Mass Spectrometry; Humans; Protein Binding; Radioimmunoassay | 1990 |
Novel irreversible aromatase inhibitors.
Topics: Aminoglutethimide; Androstadienes; Androstenedione; Animals; Aromatase Inhibitors; Female; Gonadotropins, Equine; Humans; In Vitro Techniques; Kinetics; Microsomes; Ovary; Pargyline; Placenta; Rats; Rats, Inbred Strains | 1990 |
4-hydroxyandrostenedione--further clinical and extended endocrine observations.
Topics: Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Breast Neoplasms; Endocrine Glands; Female; Humans; Menopause; Middle Aged | 1990 |
Neonatal hormone manipulations and the maintenance of perineal muscles and their motor neurones in Albino Swiss rats.
Topics: Androgen Antagonists; Androstenedione; Animals; Azasteroids; Dihydrotestosterone; Estradiol; Female; Gonadal Steroid Hormones; Male; Motor Neurons; Muscles; Organ Size; Perineum; Rats; Rats, Inbred Strains; Sex Characteristics; Testosterone | 1990 |
Development of a model for the induction of estrogen-related prostatic hyperplasia in the dog and its response to the aromatase inhibitor 4-hydroxy-4-androstene-3,17-dione: preliminary results.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Castration; Dogs; Estradiol; Male; Prostate; Prostatic Hyperplasia; Time Factors | 1986 |
In vitro effects of an aromatase inhibitor on 5 alpha-reductase activity in human hypertrophic prostatic tissue.
Topics: 5-alpha Reductase Inhibitors; Aged; Androstane-3,17-diol; Androstenedione; Aromatase Inhibitors; Azasteroids; Dihydrotestosterone; Humans; In Vitro Techniques; Male; Middle Aged; Prostatic Hyperplasia; Testosterone | 1986 |
Aromatase inhibitors and benign prostatic hyperplasia.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Gonadotropins, Equine; Humans; Kinetics; Male; Prostatic Hyperplasia; Species Specificity | 1986 |
Metabolism of androgens in human benign prostatic hyperplasia: aromatase and its inhibition.
Topics: 17-Hydroxysteroid Dehydrogenases; Androgens; Androstenedione; Aromatase; Aromatase Inhibitors; Estrone; Humans; Male; Microsomes; Placenta; Prostate; Prostatic Hyperplasia; Testolactone | 1987 |
Lack of evidence for aromatase in human prostatic tissues: effects of 4-hydroxyandrostenedione and other inhibitors on androgen metabolism.
Topics: Androstenedione; Aromatase; Cholestenone 5 alpha-Reductase; Estrogens; Humans; In Vitro Techniques; Male; Oxidoreductases; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Testosterone | 1989 |
An in vitro method to determine the selective inhibition of estrogen biosynthesis by aromatase inhibitors.
Topics: Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Cricetinae; Estrogen Antagonists; Estrogens; Estrus; Fadrozole; Female; Imidazoles; Kinetics; Luteinizing Hormone; Mesocricetus; Nitriles; Ovary; Progesterone; Testolactone; Testosterone | 1989 |
Response to endocrine manipulation and oestrogen receptor concentration in large operable primary breast cancer.
Topics: Aminoglutethimide; Androstenedione; Breast Neoplasms; Buserelin; Female; Goserelin; Humans; Menopause; Receptors, Estrogen; Tamoxifen | 1989 |
The vaginal epithelium of immature rats metabolizes androgens through an aromatase-like reaction: changes during the time of puberty.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Epithelium; Estrogens; Female; Gonadotropins, Equine; Ovary; Ovulation; Rats; Rats, Inbred Strains; Sexual Maturation; Testosterone; Vagina; Water | 1989 |
Estrogen receptors in quail brain: a functional relationship to aromatase and aggressiveness.
Topics: Aggression; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Cell Nucleus; Coturnix; Cytosol; Enzyme Induction; Estradiol; Female; Hypothalamus; In Vitro Techniques; Male; Preoptic Area; Receptors, Estrogen; Testosterone | 1989 |
Brain aromatase activity and behavioral consequences in the male rat treated in utero with 4-hydroxy-androstenedione.
Topics: Androstenedione; Animals; Aromatase; Brain; Female; Genitalia, Male; Hypothalamus; Male; Maternal-Fetal Exchange; Pregnancy; Preoptic Area; Rats; Rats, Inbred Strains; Sex Differentiation; Sexual Behavior, Animal; Testosterone | 1989 |
Quantitative determination of 4-hydroxy-4-androstene-3,17-dione (4-OHA), a potent aromatase inhibitor, in human plasma, using isotope dilution mass spectrometry.
Topics: Androstenedione; Aromatase Inhibitors; Chromatography, Gas; Humans; Mass Spectrometry | 1989 |
Effect of treatment with aromatase inhibitor 4-hydroxandrostenedione on the nonhuman primate menstrual cycle.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Estradiol; Female; Luteinizing Hormone; Menstrual Cycle; Ovary; Papio; Progesterone | 1989 |
In situ oestrone synthesis in normal breast and breast tumour tissues: effect of treatment with 4-hydroxyandrostenedione.
Topics: Aged; Androstenedione; Aromatase; Breast; Breast Neoplasms; DNA Polymerase II; Estrone; Female; Humans; Middle Aged | 1989 |
Evidence for separate sites for aromatisation of androstenedione and 16 alpha-hydroxyandrostenedione in human placental microsomes.
Topics: Androstenedione; Aromatase; Aromatase Inhibitors; Estradiol; Estriol; Estrone; Female; Humans; Hydroxyestrones; In Vitro Techniques; Kinetics; Microsomes; Placenta; Pregnancy; Radioimmunoassay | 1989 |
Formation of 4-oestrene-3,17-dione (19-norandrostenedione) by porcine granulosa cells in vitro is inhibited by the aromatase inhibitor 4-hydroxyandrostenedione and the cytochrome P-450 inhibitors aminoglutethimide phosphate and ketoconazole.
Topics: Aminoglutethimide; Androstenedione; Animals; Cells, Cultured; Female; Granulosa Cells; Ketoconazole; Swine | 1989 |
Treatment of advanced postmenopausal breast cancer with an aromatase inhibitor, 4-hydroxyandrostenedione: phase II report.
Topics: Adult; Aged; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Dehydroepiandrosterone; Drug Evaluation; Estradiol; Estrone; Female; Humans; Menopause; Middle Aged; Sex Hormone-Binding Globulin | 1986 |
Regulation of progesterone formation by human placental cells in culture.
Topics: Androstenedione; Cells, Cultured; Dehydroepiandrosterone; Dihydrotestosterone; DNA; Estradiol; Estrogen Antagonists; Ethamoxytriphetol; Female; Humans; Placenta; Pregnancy; Progesterone; Time Factors | 1986 |
Aromatase inhibitors prevent granulosa cell differentiation: an obligatory role for estrogens in luteinizing hormone receptor expression.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Cell Differentiation; Cells, Cultured; Cyclic AMP; Delayed-Action Preparations; Diethylstilbestrol; Estradiol; Estrogens; Female; Flutamide; Follicle Stimulating Hormone; Granulosa Cells; Oxidoreductases; Piperidines; Raloxifene Hydrochloride; Rats; Receptors, Cell Surface; Receptors, LH; Time Factors | 1985 |
Aromatase activity in a rat Leydig cell tumor.
Topics: Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Bucladesine; Chorionic Gonadotropin; Dihydrotestosterone; Estradiol; Estrone; Leydig Cell Tumor; Male; Neoplasm Transplantation; Rats; Rats, Inbred WF; Testicular Neoplasms; Testosterone; Tetradecanoylphorbol Acetate; Water | 1987 |
Differential responses of sex steroid target tissues of rats treated with 4-hydroxyandrostenedione.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Dihydrotestosterone; Estradiol; Female; Flutamide; Follicle Stimulating Hormone; Kinetics; Luteinizing Hormone; Mammary Neoplasms, Experimental; Organ Size; Ovariectomy; Rats; Rats, Inbred Strains; Receptors, Estrogen; Receptors, Progesterone; Uterus | 1988 |
Effects of the aromatase inhibitor 4-hydroxyandrostenedione and the antiandrogen flutamide on growth and steroid levels in DMBA-induced rat mammary tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androstenedione; Anilides; Animals; Cell Division; Female; Flutamide; Mammary Neoplasms, Experimental; Rats; Rats, Inbred Strains; Steroids | 1988 |
The effects of an aromatase inhibitor and a 5 alpha-reductase inhibitor upon the occurrence of polyovular follicles, persistent anovulation, and permanent vaginal stratification in mice treated neonatally with testosterone.
Topics: 5-alpha Reductase Inhibitors; Androstenedione; Animals; Anovulation; Aromatase Inhibitors; Epithelium; Female; Mice; Mice, Inbred C57BL; Ovarian Follicle; Progesterone; Testosterone; Vagina | 1988 |
Aromatase-inhibitors of the androstenedione-type activate the 17 beta-hydroxysteroid-dehydrogenase in the rat testis tissue suspension model.
Topics: 17-Hydroxysteroid Dehydrogenases; Androstenedione; Animals; Aromatase Inhibitors; Culture Techniques; Dihydrotestosterone; Enzyme Activation; Male; Rats; Structure-Activity Relationship; Testis; Testosterone | 1988 |
Selective 19-hydroxylase inhibition by an aromatase inhibitor, 4-hydroxyandrostenedione.
Topics: Androstenedione; Animals; Desoxycorticosterone; Humans; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY | 1988 |
A kinetic analysis of the inhibition of human prostatic 5 alpha-reductase by 4-hydroxyandrostenedione and related steroids.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Androstenedione; Humans; Kinetics; Male; Prostate | 1988 |
Structure-activity relationships of the inhibition of human placental aromatase by imidazole drugs including ketoconazole.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Humans; Imidazoles; Ketoconazole; Microsomes; Placenta; Structure-Activity Relationship | 1988 |
Effects of 4-hydroxyandrostenedione and exogenous testosterone on blood concentrations of oestradiol and oviducal embryo transport in the rat.
Topics: Androstenedione; Animals; Blastocyst; Estradiol; Female; Oviducts; Ovum Transport; Pregnancy; Rats; Rats, Inbred Strains; Testosterone | 1988 |
Mammary steroidogenesis: therapeutic implications.
Topics: 17-Hydroxysteroid Dehydrogenases; Adipose Tissue; Aminoglutethimide; Androstenedione; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Female; Humans; In Vitro Techniques | 1987 |
Metabolism of the aromatase inhibitor 4-hydroxyandrostenedione in vivo. Identification of the glucuronide as a major urinary metabolite in patients and biliary metabolite in the rat.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Bile; Female; Gas Chromatography-Mass Spectrometry; Humans; Liver; Rats; Rats, Inbred Strains | 1986 |
4-Hydroxyandrostenedione is not an aromatase inhibitor in the neonatal guinea pig.
Topics: Androstenedione; Animals; Animals, Newborn; Aromatase Inhibitors; Estradiol; Estrone; Female; Guinea Pigs; Organ Culture Techniques; Organ Size; Receptors, Estrogen; Receptors, Progesterone; Uterus | 1987 |
Antibodies to 4-hydroxyandrostenedione--a new anti-breast cancer agent suitable for use in a radioimmunoassay.
Topics: Androstenedione; Animals; Antimetabolites, Antineoplastic; Radioimmunoassay; Sheep | 1987 |
Effect of aromatase inhibitors on the histology of the cycling rat ovary.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Estradiol; Estrus; Female; Ovary; Rats; Rats, Inbred Strains; Testolactone | 1987 |
Ovine placental aromatase: studies of activity levels, kinetic characteristics and effects of aromatase inhibitors.
Topics: Androstenedione; Animals; Antifungal Agents; Aromatase; Aromatase Inhibitors; Female; Humans; Imidazoles; Kinetics; Microsomes; Placenta; Pregnancy; Sheep; Subcellular Fractions | 1987 |
Aromatization of androstenedione to estrogen by benign prostatic hyperplasia, prostate cancer and expressed prostatic secretions.
Topics: Androstenedione; Carrier Proteins; Dose-Response Relationship, Drug; Estrogens; Humans; Hyperplasia; Male; Prostate; Prostatic Neoplasms; Prostatic Secretory Proteins | 1987 |
Oral 4-hydroxyandrostenedione, a new endocrine treatment for disseminated breast cancer.
Topics: Administration, Oral; Adult; Aged; Androstenedione; Breast Neoplasms; Estradiol; Female; Humans; Menopause; Middle Aged; Neoplasm Metastasis; Ovariectomy | 1987 |
Studies on the possible existence of two 5 alpha-reductases in the rat prostate.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Age Factors; Androstenedione; Animals; Dihydrotestosterone; Isoenzymes; Male; Prostate; Rats; Rats, Inbred Strains; Testosterone | 1986 |
Aromatase inhibitors and the treatment of breast cancer.
Topics: Adult; Aged; Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Female; Humans; Kinetics; Luteinizing Hormone; Macaca mulatta; Mammary Neoplasms, Experimental; Menopause; Middle Aged; Neoplasms, Hormone-Dependent; Ovary; Rats; Tamoxifen | 1986 |
Metabolism of 4-hydroxyandrost-4-ene-3,17-dione by rat hepatocytes.
Topics: Androstenedione; Animals; Aromatase Inhibitors; In Vitro Techniques; Liver; Male; Mass Spectrometry; Rats; Rats, Inbred Strains | 1986 |
Response of nitrosomethylurea-induced rat mammary tumor to endocrine therapy and comparison with clinical response.
Topics: Aminoglutethimide; Androstenedione; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Danazol; Dihydrotestosterone; Female; Humans; Mammary Neoplasms, Experimental; Menopause; Methylnitrosourea; Ovariectomy; Rats; Tamoxifen | 1986 |
Rat testis 17 beta-estradiol: identification by gas chromatography-mass spectrometry and age related cellular distribution.
Topics: Aging; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Estradiol; Gas Chromatography-Mass Spectrometry; Leydig Cells; Male; Radioimmunoassay; Rats; Rats, Inbred Strains; Sertoli Cells; Testis | 1986 |
Effect of 1,4,6-androstatriene-3,17-dione (ATD), 4-hydroxy-4-androstene-3,17-dione (4-OH-A) and 4-acetoxy-4-androstene-3,17-dione (4-Ac-A) on the 5 alpha-reduction of androgens in the rat prostate.
Topics: Androgens; Androstatrienes; Androstenedione; Animals; Dihydrotestosterone; In Vitro Techniques; Male; Oxidation-Reduction; Prostate; Rats; Rats, Inbred Strains; Testosterone | 1986 |
Aromatase inhibitors and their potential clinical significance.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Female; Humans; Menopause; Ovary; Rats | 1986 |
The influence of 4-hydroxy-4-androstene-3,17-dione on androgen metabolism and action in cultured human foreskin fibroblasts.
Topics: Androgens; Androstenedione; Aromatase; Aromatase Inhibitors; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Fibroblasts; Humans; Kinetics; Male; Oxidoreductases; Penis; Receptors, Androgen | 1987 |
Steroid modulation of Mullerian duct regression in the chick embryo.
Topics: Aminoglutethimide; Androstenedione; Animals; Anti-Mullerian Hormone; Chick Embryo; Drug Interactions; Estrogen Antagonists; Estrogens; Female; Glycoproteins; Growth Inhibitors; Male; Mullerian Ducts; Norethindrone; Pyrrolidines; Tamoxifen; Testicular Hormones; Thiophenes | 1985 |
Effects of aromatase inhibitors, aminoglutethimide, and 4-hydroxyandrostenedione on cyclic rats and rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Estradiol; Estrus; Female; Luteinizing Hormone; Mammary Neoplasms, Experimental; Oxidoreductases; Pregnancy; Rats; Rats, Inbred Strains | 1985 |
Ovum transport in cyclic rats rendered hypo-oestrogenic by treatment with 4-hydroxy-4-androstene-3,17-dione.
Topics: Androstenedione; Animals; Estradiol; Estrus; Female; Ovary; Ovum Transport; Radioimmunoassay; Rats; Rats, Inbred Strains; Testosterone | 1986 |
Comparison of the effect of 4-hydroxy-4-androstene-3,17-dione on aromatase activity in granulosa cells from preovulatory follicles of rats, rabbits, and humans.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Estradiol; Female; Granulosa Cells; Humans; In Vitro Techniques; Ovulation; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1985 |
4-Hydroxyandrostenedione in treatment of postmenopausal patients with advanced breast cancer.
Topics: Adult; Aged; Androstenedione; Animals; Bone Neoplasms; Breast Neoplasms; Castration; Estradiol; Female; Humans; Injections, Intramuscular; Menopause; Mice; Middle Aged | 1984 |
Comparative studies of aromatase inhibitors in relation to the significance of estrogen synthesis in human mammary tumors.
Topics: Aminoglutethimide; Androgens; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Cyanoketone; Dehydroepiandrosterone; Estrogens; Female; Humans; Kinetics; Oxidoreductases; Receptors, Estrogen | 1982 |
Effects of dibutyryl cAMP, LHRH, and aromatase inhibitor on simultaneous outputs of prostaglandin F2 alpha, and 13,14-dihydro-15-keto-prostaglandin F2 alpha by term placental explants.
Topics: Androstenedione; Aromatase Inhibitors; Bucladesine; Chorionic Gonadotropin; Culture Techniques; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dinoprost; Female; Gonadotropin-Releasing Hormone; Humans; Kinetics; Lipoproteins, LDL; Placenta; Pregnancy; Prostaglandins F | 1982 |
Effects of dibutyryl adenosine 3',5'-monophosphate, luteinizing hormone-releasing hormone, and aromatase inhibitor on simultaneous outputs of progesterone, 17 beta-estradiol, and human chorionic gonadotropin by term placental explants.
Topics: Androstenedione; Bucladesine; Cholesterol; Cholesterol, LDL; Chorionic Gonadotropin; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Drug Synergism; Estradiol; Female; Gonadal Steroid Hormones; Gonadotropin-Releasing Hormone; Humans; Lipoproteins, LDL; Placenta; Pregnancy; Progesterone | 1982 |
Induction of implantation by aromatase inhibitors in ovariectomized mice.
Topics: Androstatrienes; Androstenedione; Animals; Aromatase Inhibitors; Castration; Embryo Implantation; Female; Mice; Mice, Inbred Strains; Oxidoreductases; Pregnancy; Progesterone; Testosterone | 1984 |
Biological significance of aromatase activity in human breast tumors.
Topics: Aminoglutethimide; Androstenedione; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Estrone; Female; Humans; Oxidoreductases; Receptors, Estrogen; Receptors, Progesterone; Testolactone | 1983 |
Studies on the mechanism of action of the aromatase inhibitor, 4-hydroxyandrostenedione.
Topics: Androstenedione; Aromatase Inhibitors; Female; Humans; Microsomes; Oxidoreductases; Placenta; Pregnancy | 1983 |
Characterization of the increased estrogen synthesis in skin fibroblasts from the Sebright bantam.
Topics: Androstenedione; Animals; Aromatase; Chickens; Estrogens; Female; Fibroblasts; Hot Temperature; Male; Ovary; Skin; Subcellular Fractions; Testosterone | 1983 |
Inhibition of estrogen synthesis does not inhibit luteinizing hormone-induced ovulation.
Topics: Androstenedione; Animals; Estradiol; Estrogen Antagonists; Female; In Vitro Techniques; Luteinizing Hormone; Ovulation Induction; Perfusion; Rats; Rats, Inbred Strains | 1984 |
Effects of aromatase inhibitor 4-hydroxyandrostenedione and other compounds in the 7, 12-dimethylbenz(a)anthracene-induced breast carcinoma model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androstatrienes; Androstenedione; Animals; Aromatase Inhibitors; Castration; Estrogens; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Hormone-Dependent; Ovary; Oxidoreductases; Rats | 1982 |
Effects of testosterone, estradiol, aromatase inhibitor, gonadotropin and prolactin on the response of mouse testes to acute gonadotropin stimulation.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Estradiol; Male; Mice; Mice, Inbred DBA; Progesterone; Prolactin; Testis; Testosterone | 1983 |
Synthesis of deuterium- and tritium-labelled 4-hydroxyandrostene-3,17-dione, an aromatase inhibitor, and its metabolism in vitro and in vivo in the rat.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Deuterium; Female; In Vitro Techniques; Oxidoreductases; Rats; Tritium | 1982 |
Overview of recent development of aromatase inhibitors.
Topics: Aminoglutethimide; Androstatrienes; Androstenedione; Animals; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; In Vitro Techniques; Macaca mulatta; Male; Oxidoreductases; Pregnancy; Rats | 1982 |
A new hypothesis based on suicide substrate inhibitor studies for the mechanism of action of aromatase.
Topics: Androstadienes; Androstatrienes; Androstenedione; Androstenes; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Female; Humans; Kinetics; Microsomes; Oxidoreductases; Placenta; Pregnancy; Structure-Activity Relationship; Testolactone | 1982 |
Comparative studies of aromatase inhibitors in cultured human breast cancer cells.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Cell Line; Dihydrotestosterone; Estradiol; Female; Humans; Oxidoreductases; Pargyline; Receptors, Estrogen; Receptors, Progesterone; Testolactone; Testosterone | 1982 |
Aromatase enzyme catalysis is involved in the potent inhibition of estrogen biosynthesis caused by 4-acetoxy- and 4-hydroxy-4-androstene-3, 17-dione.
Topics: Androstenedione; Aromatase Inhibitors; Catalysis; Estrogens; Female; Humans; In Vitro Techniques; Kinetics; Microsomes; Oxidoreductases; Placenta; Pregnancy; Time Factors | 1982 |
Effect of aromatase inhibitor on oestrogen production in rabbit blastocysts.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Blastocyst; Culture Techniques; Embryo Implantation; Estradiol; Female; Oxidoreductases; Rabbits; Radioimmunoassay | 1982 |
Metabolism of the aromatase inhibitor 4-hydroxy-4-androstene-3,17-dione by male rhesus monkeys.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Hydroxytestosterones; Macaca mulatta; Male; Metabolic Clearance Rate; Oxidoreductases | 1981 |
Effects of 4-hydroxy-4-androstene-3, 17-dione and 10-propargylestr-4-ene-3, 17-dione on the metabolism of androstenedione in human breast carcinoma and breast adipose tissues.
Topics: Adipose Tissue; Androstenedione; Breast; Breast Neoplasms; Female; Humans; Kinetics; Pargyline | 1981 |
Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Cell-Free System; Female; Humans; Microsomes; Ovary; Oxidoreductases; Placenta; Pregnancy; Rats; Time Factors | 1981 |
Inhibition of estrogen biosynthesis and regression of mammary tumors by aromatase inhibitors.
Topics: Androstatrienes; Androstenedione; Animals; Aromatase Inhibitors; Estrogens; Female; Humans; Macaca mulatta; Mammary Neoplasms, Experimental; Oxidoreductases; Rats | 1981 |
Inhibition of androgen aromatization in human breast cancer.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Carbon Radioisotopes; Estradiol; Estrone; Female; Humans; Kinetics; Microsomes; Oxidoreductases; Placenta; Pregnancy | 1980 |
Progress in the treatment and palliation of advanced breast cancer. Symposium proceedings. Jerusalem, 1993.
Topics: Androstenedione; Animals; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Diphosphonates; Female; Humans; Palliative Care; Pamidronate | 1994 |
Human testicular aromatase: immunocytochemical and biochemical studies.
Topics: Adolescent; Adult; Aged; Aging; Androstenedione; Aromatase; Child, Preschool; Humans; Immunohistochemistry; Infant; Leydig Cells; Male; Middle Aged; Puberty; Sertoli Cells; Spermatozoa; Staining and Labeling; Testis; Tissue Distribution | 1995 |
Effect of aromatase inhibitors on growth of mammary tumors in a nude mouse model.
Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase Inhibitors; Cell Division; Fadrozole; Female; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Organ Size; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles; Uterus | 1995 |
Formestane: an effective first-line endocrine treatment for advanced breast cancer.
Topics: 17-Hydroxycorticosteroids; Aged; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Administration Schedule; Estradiol; Female; Humans; Injections, Intramuscular; Middle Aged; Postmenopause; Prognosis; Risk Factors; Survival Analysis; Treatment Outcome | 1995 |
Enzymatic and nonenzymatic polarizations of alpha,beta-unsaturated ketosteroids and phenolic steroids. Implications for the roles of hydrogen bonding in the catalytic mechanism of delta 5-3-ketosteroid isomerase.
Topics: Androstenedione; Catalysis; Equilenin; Hydrogen Bonding; Ketosteroids; Multienzyme Complexes; Phenols; Progesterone Reductase; Solvents; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Steroid Isomerases | 1995 |
Effects of steroidal and non steroidal aromatase inhibitors on sexual behavior and aromatase-immunoreactive cells and fibers in the quail brain.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Brain; Coturnix; Drug Implants; Immunoenzyme Techniques; Male; Nerve Fibers; Sexual Behavior, Animal; Testosterone; Triazoles | 1994 |
The effect of aromatase inhibitor 4-hydroxyandrostenedione on steroid receptors in hormone-dependent tissues of the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androstenedione; Animals; Aromatase Inhibitors; Estradiol; Female; Mammary Neoplasms, Experimental; Ovariectomy; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid; RNA, Messenger; Uterus | 1995 |
Treatment of advanced breast cancer with formestane.
Topics: Adult; Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Middle Aged; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Receptors, Estrogen; Remission Induction; Survival Analysis | 1994 |
Aromatase inhibition: basic concepts, and the pharmacodynamics of formestane.
Topics: Androstenedione; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Postmenopause | 1994 |
Analysis of the aromatase cytochrome P450 gene in human breast cancers.
Topics: Androstenedione; Aromatase; Aromatase Inhibitors; Base Sequence; Breast Neoplasms; Cloning, Molecular; DNA Mutational Analysis; DNA Probes; Estradiol; Exons; Female; Humans; In Vitro Techniques; Molecular Sequence Data; Placenta; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational | 1994 |
Role of P-450 aromatase in sex determination of the diamondback terrapin, Malaclemys terrapin.
Topics: Amino Acid Sequence; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Behavior, Animal; Cloning, Molecular; Estradiol; Fadrozole; Female; Humans; Male; Molecular Sequence Data; Sequence Homology, Amino Acid; Sex Differentiation; Turtles | 1994 |
Changes induced by treatment with aromatase inhibitors in testicular Leydig cells of rats and dogs.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Dogs; Genitalia, Male; Letrozole; Leydig Cells; Male; Nitriles; Rats; Species Specificity; Triazoles | 1994 |
Chemopreventive effects of the aromatase inhibitors vorozole (R-83842) and 4-hydroxyandrostenedione in the methylnitrosourea (MNU)-induced mammary tumor model in Sprague-Dawley rats.
Topics: Adenocarcinoma; Aminoglutethimide; Androstenedione; Animals; Anticarcinogenic Agents; Aromatase Inhibitors; Drug Screening Assays, Antitumor; Estrus; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Triazoles | 1994 |
Mutagenesis study at a postulated hydrophobic region near the active site of aromatase cytochrome P450.
Topics: Amino Acid Sequence; Aminoglutethimide; Androstenedione; Aromatase; Aromatase Inhibitors; Binding Sites; Computer Simulation; DNA Mutational Analysis; Dose-Response Relationship, Drug; Fadrozole; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship | 1994 |
Plasma and urinary oestrogens in breast cancer patients on treatment with 4-hydroxyandrostenedione.
Topics: Aged; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Female; Humans; Male; Menopause; Middle Aged | 1993 |
Effect of aromatase inhibitors on estrogen 2-hydroxylase in rat liver.
Topics: Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Binding, Competitive; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Estradiol; Estrone; Fadrozole; Female; Ketoconazole; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Steroid Hydroxylases; Substrate Specificity | 1994 |
Effectiveness of combined limonene and 4-hydroxyandrostenedione in the treatment of NMU-induced rat mammary tumours.
Topics: Androstenedione; Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclohexenes; Drug Screening Assays, Antitumor; Female; Limonene; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Inbred Strains; Terpenes | 1994 |
Combined treatment with 4-hydroxyandrostenedione and aminoglutethimide: effects on aromatase inhibition and oestrogen suppression.
Topics: Adult; Aged; Aminoglutethimide; Androstenedione; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Carbon Radioisotopes; Estrogens; Female; Humans; Middle Aged; Postmenopause; Radioisotope Dilution Technique | 1994 |
Effects of an aromatase inhibitor on thymus and kidney and on oestrogen receptors in female MRL/MP-lpr/lpr mice.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Cell Nucleus; Cytosol; Disease Models, Animal; Estrogens; Female; Kidney; Liver; Lupus Erythematosus, Systemic; Mice; Mice, Mutant Strains; Organ Size; Receptors, Estrogen; Thymus Gland; Uterus | 1993 |
Lack of influence of aromatase and 5 alpha-reductase inhibition on [3H]imipramine binding in the male rat brain.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Azasteroids; Brain; Dihydrotestosterone; Gonadal Steroid Hormones; Imipramine; Male; Rats; Rats, Wistar | 1993 |
Pregnancy can be established in superovulated adult rats treated with progesterone and an aromatase inhibitor.
Topics: Analysis of Variance; Androstenedione; Animals; Aromatase Inhibitors; Embryo Implantation; Estradiol; Female; Pregnancy; Pregnancy Maintenance; Pregnancy, Animal; Progesterone; Rats; Rats, Sprague-Dawley; Superovulation | 1993 |
Gonadal differentiation and secretions of estradiol and testosterone of the ovaries of Rana catesbeiana tadpoles treated with 4-hydroxyandrostenedione.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Estradiol; Female; Oogenesis; Ovary; Rana catesbeiana; Testosterone | 1993 |
Growth suppression of MCF-7 human breast cancer cells by aromatase inhibitors: a new system for aromatase inhibitor screening.
Topics: Aminoglutethimide; Androstenedione; Androstenols; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Fadrozole; Female; Humans; Kinetics; Tumor Cells, Cultured | 1993 |
MCF-7 human breast carcinomas in nude mice as a model for evaluating aromatase inhibitors.
Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cell Division; Female; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Tamoxifen; Transplantation, Heterologous; Tumor Cells, Cultured | 1993 |
Efficacy and tolerability of 4-hydroxyandrostenedione (4-OHA) as first-line treatment in postmenopausal patients with breast cancer after adjuvant therapy.
Topics: Aged; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Menopause; Methotrexate; Middle Aged; Remission Induction; Tamoxifen; Treatment Outcome | 1993 |
Biochemical significance of 19-hydroxytestosterone in the process of aromatization in human corpus luteum.
Topics: Adult; Androstenedione; Aromatase Inhibitors; Corpus Luteum; Enzyme Inhibitors; Estradiol; Female; Humans; Hydroxytestosterones; Microsomes; Testosterone | 1994 |
Dual regulation of luteal progesterone production by androstenedione during spontaneous and RU486-induced luteolysis in pregnant rats.
Topics: 17-Hydroxysteroid Dehydrogenases; 20-alpha-Hydroxysteroid Dehydrogenase; 20-Hydroxysteroid Dehydrogenases; Adrenalectomy; Androstenedione; Animals; Aromatase Inhibitors; Cells, Cultured; Corpus Luteum; Dihydrotestosterone; Estradiol; Female; Hormone Antagonists; Luteolysis; Luteolytic Agents; Menstruation-Inducing Agents; Mifepristone; Organ Size; Polyunsaturated Alkamides; Pregnancy; Pregnancy, Animal; Progesterone; Rats; Rats, Wistar; Testosterone | 1995 |
A sensitive assay for measurement of plasma estrone sulphate in patients on treatment with aromatase inhibitors.
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrone; Female; Humans; Hydrolysis; Menopause; Radioimmunoassay; Sensitivity and Specificity | 1995 |
Aromatase inhibitors: synthesis, biological activity, and structure of 1,2-imidazolylmethylcyclopentanol derivatives.
Topics: Androstenedione; Aromatase Inhibitors; Crystallography, X-Ray; Cyclopentanes; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Microsomes; Placenta; Pregnancy | 1995 |
The synthesis of 19-norandrostenedione from dehydroepiandrosterone in equine placenta is inhibited by aromatase inhibitors 4-hydroxyandrostenedione and fadrozole.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Dehydroepiandrosterone; Enzyme Inhibitors; Fadrozole; Female; Horses; Placenta; Pregnancy | 1995 |
Assesssment of the effect of pretreatment with neoadjuvant therapy on primary breast cancer.
Topics: Adult; Aged; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Goserelin; Humans; Immunohistochemistry; Methotrexate; Middle Aged; Mitomycin; Mitoxantrone; Neoplasms, Hormone-Dependent; Receptors, Estrogen | 1996 |
Inhibition of aromatase activity and growth suppression by 4-methoxy-4-androstene-3,17-dione in an androgen sensitive human prostatic carcinoma cell line.
Topics: Androstenedione; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Cell Division; Culture Media, Serum-Free; Drug Screening Assays, Antitumor; Humans; Male; Prostatic Neoplasms; Testosterone; Tumor Cells, Cultured | 1996 |
Characterization of oviductal aromatase in the northern leopard frog, Rana pipiens.
Topics: Androstenedione; Animals; Aromatase; Enzyme Inhibitors; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Microsomes; Oviducts; Placenta; Pregnancy; Rana pipiens; Thermodynamics | 1996 |
The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)--a potent, selective aromatase inhibitor.
Topics: Adrenal Glands; Aminoglutethimide; Anastrozole; Androstenedione; Animals; Aromatase Inhibitors; Cortodoxone; Enzyme Inhibitors; Fadrozole; Female; Hormones; Humans; Macaca nemestrina; Male; Metyrapone; Nitriles; Organ Size; Potassium; Prostate; Rats; Rats, Wistar; Seminal Vesicles; Sodium; Triazoles; Uterus | 1996 |
Estrogen regulates vascular endothelial growth/permeability factor expression in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androstenedione; Animals; Endothelial Growth Factors; Enzyme Inhibitors; Estradiol; Female; Immunohistochemistry; Lymphokines; Mammary Glands, Animal; Mammary Neoplasms, Animal; Ovariectomy; Rats; Rats, Sprague-Dawley; Reference Values; RNA, Messenger; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1996 |
Oestrogen formation in breast: clinical and biological importance.
Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast; Breast Neoplasms; Estrogens; Female; Humans; Letrozole; Mice; Mice, Nude; Nitriles; Signal Transduction; Transfection; Triazoles; Tumor Cells, Cultured | 1996 |
Effects of treatment with megestrol acetate, aminoglutethimide, or formestane on insulin-like growth factor (IGF) I and II, IGF-binding proteins (IGFBPs), and IGFBP-3 protease status in patients with advanced breast cancer.
Topics: Aged; Aged, 80 and over; Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Blotting, Western; Breast Neoplasms; Endopeptidases; Female; Humans; Insulin-Like Growth Factor Binding Proteins; Megestrol Acetate; Middle Aged; Radioimmunoassay; Somatomedins | 1996 |
Equine cytochrome P450 aromatase exhibits an estrogen 2-hydroxylase activity in vitro.
Topics: Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Fadrozole; Horses; Immune Sera; Kinetics; Male; Miconazole; Microsomes; Placenta; Steroid Hydroxylases; Substrate Specificity; Testis; Testosterone | 1996 |
Hypoglycaemia associated with formestane treatment.
Topics: Androstenedione; Antineoplastic Agents; Breast Neoplasms; Diabetes Complications; Female; Humans; Hypoglycemia; Middle Aged | 1997 |
Fetal death in mice lacking 5alpha-reductase type 1 caused by estrogen excess.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Anastrozole; Androstenedione; Animals; Biological Assay; Decidua; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Estrogen Antagonists; Estrogens; Female; Fetal Death; Gene Expression Regulation, Enzymologic; In Situ Hybridization; Litter Size; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitriles; Placenta; RNA, Messenger; Steroids; Tamoxifen; Triazoles; Uterus | 1997 |
Serum markers of bone metastases in postmenopausal breast cancer patients treated with formestane.
Topics: Alkaline Phosphatase; Androstenedione; Antineoplastic Agents; Biomarkers, Tumor; Bone Neoplasms; Breast Neoplasms; Calcium-Binding Proteins; Extracellular Matrix Proteins; Female; Humans; Matrix Gla Protein; Peptide Fragments; Postmenopause; Procollagen | 1997 |
Aromatase inhibitors come of age.
Topics: Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Nitriles; Triazoles | 1997 |
Aromatase inhibitors for breast cancer--further progress.
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Female; Humans; Megestrol Acetate | 1997 |
Dehydroepiandrosterone stimulates the estrogen response element.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Cell Line; Dehydroepiandrosterone; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Fulvestrant; Genes, Reporter; Genetic Vectors; Humans; Luciferases; Mice; Receptors, Estrogen; Transfection | 1997 |
The effects of aromatase and 5 alpha-reductase inhibitors, antiandrogen, and sex steroids on Bidder's organs development and gonadal differentiation in Bufo bufo tadpoles.
Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Androstenedione; Animals; Bufo bufo; Embryo, Nonmammalian; Enzyme Inhibitors; Female; Gonadal Steroid Hormones; Gonads; Male; Testosterone | 1998 |
Inhibitors of aromatase prevent degradation of the enzyme in cultured human tumour cells.
Topics: Androstenedione; Aromatase; Aromatase Inhibitors; Carcinoma, Hepatocellular; Choriocarcinoma; Colforsin; Cycloheximide; Enzyme-Linked Immunosorbent Assay; Fadrozole; Humans; Liver Neoplasms; Neoplasm Proteins; Protein Synthesis Inhibitors; RNA, Messenger; Triazoles; Tumor Cells, Cultured | 1998 |
Inhibition and inactivation of equine aromatase by steroidal and non-steroidal compounds. A comparison with human aromatase inhibition.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Enzyme Activation; Fadrozole; Horses; Humans; Imidazoles; Ketoconazole; Male; Miconazole; Substrate Specificity | 1997 |
Activin-A stimulates hypothalamic gonadotropin-releasing hormone release by the explanted male rat hypothalamus: interaction with inhibin and androgens.
Topics: Activins; Androstenedione; Animals; Aromatase Inhibitors; Dihydrotestosterone; Enzyme Inhibitors; Feedback; Gonadotropin-Releasing Hormone; Hypothalamus; Inhibins; Male; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Testosterone | 1998 |
Tamoxifen-resistant fibroblast growth factor-transfected MCF-7 cells are cross-resistant in vivo to the antiestrogen ICI 182,780 and two aromatase inhibitors.
Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cell Division; Cell Line; Chloramphenicol O-Acetyltransferase; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fibroblast Growth Factors; Fulvestrant; Humans; Letrozole; Luciferases; Mice; Mice, Nude; Nitriles; Ovariectomy; Polymerase Chain Reaction; Receptors, Progesterone; Recombinant Fusion Proteins; RNA, Messenger; Tamoxifen; Transcription, Genetic; Transfection; Transplantation, Heterologous; Triazoles; Tumor Cells, Cultured | 1998 |
Local paracrine effects of estradiol are central to parturition in the rhesus monkey.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Electromyography; Enzyme Inhibitors; Estradiol; Female; Humans; Infusions, Intravenous; Labor, Obstetric; Macaca mulatta; Myometrium; Oxytocin; Pregnancy; Progesterone; Uterine Contraction | 1998 |
Severe immune thrombocytopenia during formestane treatment.
Topics: Androstenedione; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Middle Aged; Neoplasm Metastasis; Postmenopause; Thrombocytopenia | 1998 |
Pharmacokinetics of 4-hydroxyandrostenedione in man after intramuscular injection of different formulations and the effect of this drug on plasma aromatizable androgens and 17beta-estradiol concentrations.
Topics: Androgens; Androstenedione; Aromatase Inhibitors; Chemistry, Pharmaceutical; Enzyme Inhibitors; Estradiol; Gas Chromatography-Mass Spectrometry; Humans; Injections, Intramuscular; Male; Particle Size; Reproducibility of Results; Sensitivity and Specificity; Testosterone | 1993 |
The steroidal antiestrogen ICI 182,780 is an inhibitor of cellular aromatase activity.
Topics: Anastrozole; Androstenedione; Aromatase; Aromatase Inhibitors; Base Sequence; Breast Neoplasms; Cell Division; Cells, Cultured; Choriocarcinoma; DNA Primers; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fibroblasts; Fulvestrant; Humans; Letrozole; Microsomes; Nitriles; Placenta; RNA, Messenger; Triazoles; Tumor Cells, Cultured | 1998 |
Influence of aromatase inhibitors on plasma total homocysteine in postmenopausal breast cancer patients.
Topics: Aminoglutethimide; Androstadienes; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Creatinine; Enzyme Inhibitors; Estrogen Antagonists; Homocysteine; Humans; Postmenopause; Vitamins | 1999 |
[Carcinomatous meningitis secondary to breast cancer. Spectacular response to hormone therapy].
Topics: Aged; Androstenedione; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Mastectomy; Meningeal Neoplasms; Remission Induction; Tamoxifen; Treatment Outcome | 1999 |
The aromatase inactivator 4-hydroxyandrostenedione (4-OH-A) inhibits tamoxifen metabolism by rat hepatic cytochrome P-450 3A: potential for drug-drug interaction of tamoxifen and 4-OH-A in combined anti-breast cancer therapy.
Topics: Androstenedione; Animals; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase; Aromatase Inhibitors; Aryl Hydrocarbon Hydroxylases; Breast Neoplasms; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Activation; Liver; Male; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; Tamoxifen | 1999 |
Evidence for sexual dimorphism of estrogen receptors in hypothalamus and thymus of neonatal and immature Wistar rats.
Topics: Age Factors; Androstenedione; Animals; Aromatase Inhibitors; Cytosol; Drug Implants; Estradiol; Female; Hypothalamus; Male; Rats; Rats, Wistar; Receptors, Estrogen; Sex Characteristics; Sex Differentiation; Sexual Maturation; Thymus Gland; Uterus | 1999 |
Estrogen synthesis in human colon cancer epithelial cells.
Topics: Androstenedione; Antineoplastic Agents, Hormonal; Aromatase; Colorectal Neoplasms; Estrogen Antagonists; Estrogens; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genistein; Humans; Kinetics; Quercetin; Raloxifene Hydrochloride; RNA, Messenger; Tamoxifen; Tumor Cells, Cultured | 1999 |
Pilot study of formestane in postmenopausal women with breast cancer.
Topics: Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Middle Aged; Pilot Projects; Postmenopause | 1998 |
The aromatase inhibitor, 4-hydroxyandrostenedione, restores immune responses following trauma-hemorrhage in males and decreases mortality from subsequent sepsis.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Cytokines; Enzyme Inhibitors; Estrogen Receptor alpha; Estrogen Receptor beta; Male; Mice; Mice, Inbred C3H; Receptors, Androgen; Receptors, Estrogen; Resuscitation; Sepsis; Shock, Hemorrhagic; Spleen; Survival Rate; Th1 Cells; Wounds and Injuries | 2000 |
Formestane is feasible and effective in elderly breast cancer patients with comorbidity and disability.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cardiovascular Diseases; Comorbidity; Enzyme Inhibitors; Female; Geriatric Assessment; Humans; Injections, Intramuscular; Treatment Outcome | 2000 |
Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females.
Topics: Androgen Antagonists; Androstenedione; Animals; Antibodies; Aromatase Inhibitors; Cells, Cultured; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogens; Flutamide; Fulvestrant; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Male; Osteoblasts; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Stress, Mechanical; Tamoxifen; Testosterone; Thymidine | 2000 |
Effects of a new selective estrogen receptor modulator (MDL 103,323) on cancellous and cortical bone in ovariectomized ewes: a biochemical, histomorphometric, and densitometric study.
Topics: Alkaline Phosphatase; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Biomarkers; Bone and Bones; Bone Density; Bone Remodeling; Clomiphene; Collagen; Female; Femur; Ilium; Osteocalcin; Osteoporosis; Ovariectomy; Peptide Fragments; Selective Estrogen Receptor Modulators; Sheep; Spine; Time Factors | 2001 |
Dehydroepiandrosterone stimulates proliferation and gene expression in MCF-7 cells after conversion to estradiol.
Topics: Androstenedione; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Division; Chromatography, Thin Layer; Dehydroepiandrosterone; Dexamethasone; Dihydrotestosterone; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; Humans; Immunoassay; Mitogens; Tamoxifen; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2001 |
Testosterone inhibits osteoclast formation stimulated by parathyroid hormone through androgen receptor.
Topics: Androgen Antagonists; Androstenedione; Animals; Aromatase Inhibitors; Cell Division; Cells, Cultured; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Flutamide; Fulvestrant; Glucuronates; Mice; Mice, Inbred ICR; Osteoclasts; Parathyroid Hormone; Receptors, Androgen; Teriparatide; Testosterone | 2001 |
[Aromatase inhibitors].
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Enzyme Inhibitors; Tamoxifen | 2000 |
Pharmacokinetics and metabolism of formestane in breast cancer patients.
Topics: Aged; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Biological Availability; Biotransformation; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Middle Aged | 2001 |
Effects of 4-hydroxyandrostenedione and hyperstimulation with pregnant mare serum gonadotrophin on early embryonic development in rats.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Estradiol; Female; Gonadotropins, Equine; Pregnancy; Rats; Rats, Wistar | 2001 |
Formestane, a steroidal aromatase inhibitor after failure of non-steroidal aromatase inhibitors (anastrozole and letrozole): is a clinical benefit still achievable?
Topics: Adult; Aged; Anastrozole; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Disease Progression; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Retrospective Studies; Treatment Failure; Triazoles | 2001 |
X-ray and deuterium labeling studies on the abnormal ring cleavages of a 5 beta-epoxide precursor of formestane.
Topics: Androstanols; Androstenedione; Androstenes; Antineoplastic Agents; Aromatase Inhibitors; Deuterium; Enzyme Inhibitors; Isomerism; Isotope Labeling; Magnetic Resonance Spectroscopy; Molecular Structure; Oxidation-Reduction; X-Rays | 2002 |
Effects of cortisol and oestradiol on hepatic 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor proteins in late-gestation sheep fetus.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Analysis of Variance; Androstenedione; Animals; Aromatase Inhibitors; Blotting, Western; Enzyme Inhibitors; Estradiol; Female; Gestational Age; Hydrocortisone; Hydroxysteroid Dehydrogenases; Immunohistochemistry; Liver; Microsomes, Liver; Pregnancy; Receptors, Glucocorticoid; Sheep; Stimulation, Chemical | 2003 |
Role of aromatase and androgen receptor expression in gonadal sex differentiation of ZW/ZZ-type frogs, Rana rugosa.
Topics: Androgen Antagonists; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Enzyme Inhibitors; Estradiol; Female; Gonads; Hermaphroditic Organisms; Larva; Male; Ovary; Ranidae; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sex Determination Analysis; Sex Determination Processes; Sex Differentiation; Testis | 2003 |
Androgen-mediated modulation of macrophage function after trauma-hemorrhage: central role of 5alpha-dihydrotestosterone.
Topics: Androgens; Androstenedione; Animals; Cell Separation; Cell Survival; Cells, Cultured; Cytokines; Dihydrotestosterone; Gene Expression; Hemorrhage; Kupffer Cells; Macrophages; Male; Mice; Mice, Inbred C3H; Reverse Transcriptase Polymerase Chain Reaction; Shock, Hemorrhagic; Spleen; Testosterone; Wounds and Injuries | 2003 |
Effect of antiestrogens and aromatase inhibitor on basal growth of the human breast cancer cell line MCF-7 in serum-free medium.
Topics: Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cell Division; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor Modulators; Fulvestrant; Humans; Ligands; Membrane Proteins; Piperidines; Presenilin-2; Protein Binding; Receptors, Estrogen; RNA, Messenger; Tamoxifen; Time Factors; Tumor Cells, Cultured | 2003 |
[Effects of formestane on the skeletal system in ovariectomized and control rates].
Topics: Androstenedione; Animals; Aromatase Inhibitors; Bone and Bones; Bone Diseases, Metabolic; Bone Remodeling; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Ovariectomy; Random Allocation; Rats; Rats, Wistar; Time Factors | 2003 |
Brain estradiol content in newborn rats: sex differences, regional heterogeneity, and possible de novo synthesis by the female telencephalon.
Topics: Aging; Androstenedione; Animals; Animals, Newborn; Aromatase Inhibitors; Brain; Enzyme Inhibitors; Estradiol; Female; Male; Rats; Rats, Sprague-Dawley; Sex Characteristics; Telencephalon; Tissue Distribution | 2004 |
Aromatase inhibitors increase the sensitivity of human tumor cells to monocyte-mediated, antibody-dependent cellular cytotoxicity.
Topics: Androstenedione; Antibody-Dependent Cell Cytotoxicity; Aromatase Inhibitors; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Female; Humans; Monocytes; Mucin-1; Ovarian Neoplasms; Peptide Elongation Factor 1; Receptors, Estrogen | 2005 |
Cyclooxygenase-2 directly regulates gene expression of P450 Cyp19 aromatase promoter regions pII, pI.3 and pI.7 and estradiol production in human breast tumor cells.
Topics: Androstenedione; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Celecoxib; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Estradiol; Female; Gene Expression Regulation, Enzymologic; Humans; Promoter Regions, Genetic; Pyrazoles; Sulfonamides | 2006 |
Gastric estrogen directly induces ghrelin expression and production in the rat stomach.
Topics: Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Cells, Cultured; Estradiol; Estrogen Receptor alpha; Female; Gastric Mucosa; Ghrelin; Immunohistochemistry; Male; Orchiectomy; Ovariectomy; Peptide Hormones; Radioimmunoassay; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach | 2006 |
Aromatase destabilizer: novel action of exemestane, a food and drug administration-approved aromatase inhibitor.
Topics: Androstadienes; Androstenedione; Aromatase; Aromatase Inhibitors; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Stability; Female; Humans; Proteasome Endopeptidase Complex | 2006 |
Metabolism of 4-hydroxyandrostenedione and 4-hydroxytestosterone: Mass spectrometric identification of urinary metabolites.
Topics: Adult; Anabolic Agents; Androstenedione; Biotransformation; Doping in Sports; Gas Chromatography-Mass Spectrometry; Humans; Magnetic Resonance Spectroscopy; Male; Reference Standards; Testosterone | 2007 |
Coadministration of the aromatase inhibitor formestane and an isopropanolic extract of black cohosh in a rat model of chemically induced mammary carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androstenedione; Animals; Antineoplastic Agents, Phytogenic; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cimicifuga; Drug Therapy, Combination; Estradiol; Female; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley | 2007 |
Estrogens participate in the antidepressant-like effect of desipramine and fluoxetine in male rats.
Topics: Androstenedione; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Aromatase Inhibitors; Brain Chemistry; Desipramine; Estradiol; Estrogens; Female; Fluoxetine; Male; Motor Activity; Orchiectomy; Ovariectomy; Rats; Swimming; Testosterone | 2008 |
The effects of aromatase inhibitors and selective estrogen receptor modulators on eye development in the zebrafish (Danio rerio).
Topics: Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Clomiphene; Embryo, Nonmammalian; Embryonic Development; Estrogens; Eye; Retina; Selective Estrogen Receptor Modulators; Tamoxifen; Zebrafish | 2007 |
In vitro expansion of human breast cancer epithelial and mesenchymal stromal cells: optimization of a coculture model for personalized therapy approaches.
Topics: Androstenedione; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Aromatase; Aromatase Inhibitors; Base Sequence; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Coculture Techniques; Cryopreservation; DNA Primers; Epithelial Cells; Humans; Mesoderm; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stromal Cells; Trastuzumab | 2007 |
Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna.
Topics: Androstenedione; Animals; Daphnia; Endocrine Disruptors; Fertility; Fresh Water; Life Cycle Stages; Reproduction; Testosterone; Toxicity Tests, Acute; Toxicity Tests, Chronic; Water Pollutants, Chemical | 2008 |
The role of estrogen in the developmental appearance of sensory-motor behaviors in the zebrafish (Danio rerio): the characterization of the "listless" model.
Topics: Age Factors; Androstenedione; Animals; Aromatase Inhibitors; Behavior, Animal; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Embryonic Development; Estradiol; Estrogen Antagonists; Estrogens; Fulvestrant; Heart Rate; Locomotion; Motor Activity; Nervous System; Physical Stimulation; Swimming; Vestibule, Labyrinth; Zebrafish | 2008 |
Synthesis and evaluation of novel 4-amino-4,6-androstadiene-3,17-dione: an analog of formestane.
Topics: Androstadienes; Androstenedione; Antineoplastic Agents; Aromatase; Breast Neoplasms; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Design; Drug Screening Assays, Antitumor; Humans; Models, Chemical | 2008 |
Resting intracellular calcium concentration, depolarizing Gamma-Aminobutyric Acid and possible role of local estradiol synthesis in the developing male and female hippocampus.
Topics: Androstenedione; Animals; Animals, Newborn; Aromatase Inhibitors; Calcium; Cells, Cultured; Chelating Agents; Egtazic Acid; Estradiol; Estrogen Antagonists; Excitatory Amino Acid Agents; Extracellular Fluid; Female; Fulvestrant; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; Male; Muscimol; Neurons; Organophosphonates; Piperazines; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2 | 2009 |
The detection of androstenedione abuse in sport: a mass spectrometry strategy to identify the 4-hydroxyandrostenedione metabolite.
Topics: Adult; Androstenedione; Chromatography, Gas; Chromatography, High Pressure Liquid; Doping in Sports; Humans; Male; Mass Screening; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Substance Abuse Detection; Young Adult | 2008 |
Testosterone reduces cumulative burying in female Wistar rats with minimal participation of estradiol.
Topics: Androstenedione; Animals; Anti-Anxiety Agents; Aromatase Inhibitors; Estradiol; Estrogen Antagonists; Female; GABA Antagonists; GABA-A Receptor Antagonists; Motor Activity; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Tamoxifen; Testosterone | 2009 |
A suite of activity-based probes for human cytochrome P450 enzymes.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Cytochrome P-450 Enzyme System; Drug Design; Humans; Mice; Pharmaceutical Preparations; Staining and Labeling | 2009 |
Computer-aided structure analysis of an epimerized dehydroepiandrosterone derivative and its biological effect in a model of reactive gliosis.
Topics: Androstadienes; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Crystallography, X-Ray; Dehydroepiandrosterone; Glial Fibrillary Acidic Protein; Gliosis; Male; Molecular Sequence Data; Molecular Structure; Rats; Rats, Wistar | 2010 |
Combined inhibitory effect of formestane and herceptin on a subpopulation of CD44+/CD24low breast cancer cells.
Topics: Androstenedione; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase; Aromatase Inhibitors; Breast Neoplasms; CD24 Antigen; Cell Line, Tumor; DNA Primers; ErbB Receptors; Female; Humans; Hyaluronan Receptors; Receptor Cross-Talk; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Trastuzumab; Tumor Cells, Cultured | 2010 |
Identification of early transcripts related to male development in chicken embryos.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Brain; Chick Embryo; Female; Gene Expression Regulation, Developmental; Gene Library; Gonads; Male; RNA, Messenger; Sex Characteristics | 2010 |
Investigations on carbon isotope ratios and concentrations of urinary formestane.
Topics: Adult; Androstenedione; Aromatase Inhibitors; Biomarkers; Calibration; Carbon Isotopes; Doping in Sports; Female; Gas Chromatography-Mass Spectrometry; Humans; Limit of Detection; Male; Middle Aged; Performance-Enhancing Substances; Predictive Value of Tests; Reference Values; Reproducibility of Results; Substance Abuse Detection; Young Adult | 2012 |
Metabolic studies of formestane in horses.
Topics: Administration, Oral; Androstenedione; Animals; Aromatase Inhibitors; Chromatography, High Pressure Liquid; Doping in Sports; Gas Chromatography-Mass Spectrometry; Horses | 2013 |
Steroid synthesis by Taenia crassiceps WFU cysticerci is regulated by enzyme inhibitors.
Topics: Androstenedione; Animals; Chromatography, Thin Layer; Danazol; Desoxycorticosterone; Enzyme Inhibitors; Estradiol; Ketoconazole; Steroids; Taenia | 2013 |
Gender Based Differences in Stress-induced Gastric Ulcer Formation and its Regulation by Nitric Oxide (NO): An Experimental Study.
Topics: Androstenedione; Animals; Arginine; Aromatase Inhibitors; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogens; Female; Glutathione; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats, Wistar; Severity of Illness Index; Sex Factors; Signal Transduction; Stomach Ulcer; Stress, Psychological | 2015 |
Profiling of urinary formestane and confirmation by isotope ratio mass spectrometry.
Topics: Adult; Androstenedione; Carbon Isotopes; Doping in Sports; Female; Humans; Limit of Detection; Male; Mass Spectrometry; Reproducibility of Results; Urinalysis; Young Adult | 2013 |
Synthesis and bioconversions of formestane.
Topics: Androstenedione; Aromatase Inhibitors; Beauveria; Biotransformation; Breast Neoplasms; Female; Humans; Stereoisomerism; Testosterone | 2013 |
Possible role of nitric oxide (NO) in the regulation of gender related differences in stress induced anxiogenesis in rats.
Topics: Androstenedione; Animals; Anxiety; Arginine; Behavior, Animal; Brain; Enzyme Inhibitors; Female; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Sex Factors; Stress, Physiological | 2014 |
Antidoping programme and biological monitoring before and during the 2014 FIFA World Cup Brazil.
Topics: Amphetamine; Androstenedione; Blood Chemical Analysis; Brazil; Clenbuterol; Doping in Sports; Glucocorticoids; Humans; Soccer; Specimen Handling; Steroids; Substance Abuse Detection; Tramadol; Urinalysis | 2015 |
Interactions of an anticancer drug Formestane with single and double stranded DNA at physiological conditions.
Topics: Androstenedione; Animals; Antineoplastic Agents; Cattle; DNA, Single-Stranded; Electrochemistry; Humans; Hydrogen-Ion Concentration; Nucleic Acid Conformation; Thermodynamics | 2015 |
Are sex steroids essential for gonadal differentiation of the ornate frog, Microhyla ornata?
Topics: Androstenedione; Animals; Anura; Aromatase Inhibitors; Cell Differentiation; Estradiol; Female; Gonadal Steroid Hormones; Gonads; Larva; Male; Metamorphosis, Biological; Ovary; Sex Differentiation; Sex Ratio; Tamoxifen; Testis; Testosterone | 2016 |
Determination and confirmation of selective estrogen receptor modulators (SERMs), anti-estrogens and aromatase inhibitors in bovine and porcine urine using UHPLC-MS/MS.
Topics: Androstenedione; Animal Husbandry; Animals; Aromatase Inhibitors; Cattle; Chromatography, High Pressure Liquid; Drug and Narcotic Control; Limit of Detection; Reproducibility of Results; Selective Estrogen Receptor Modulators; Substance Abuse Detection; Swine; Tandem Mass Spectrometry | 2017 |
Angela M. Hartley Brodie (1934-2017).
Topics: Androstadienes; Androstenedione; Aromatase Inhibitors; Benzimidazoles; Breast Neoplasms; Estrogens; Female; History, 20th Century; History, 21st Century; Humans; Male; Maryland; Prostatic Neoplasms | 2017 |
Sex differences in microRNA-mRNA networks: examination of novel epigenetic programming mechanisms in the sexually dimorphic neonatal hypothalamus.
Topics: Androstenedione; Animals; Animals, Newborn; Aromatase Inhibitors; Epigenesis, Genetic; Estrogens; Gene Regulatory Networks; Hypothalamus; Mice, 129 Strain; Mice, Inbred C57BL; Microarray Analysis; MicroRNAs; Multivariate Analysis; RNA, Messenger; Sex Characteristics; Transcriptome | 2017 |
Acute developmental exposure to 4-hydroxyandrostenedione has a long-term effect on visually-guided behaviors.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Behavior, Animal; Embryo, Nonmammalian; Embryonic Development; Endocrine Disruptors; Photic Stimulation; Psychomotor Performance; Vision, Ocular; Visual Perception; Zebrafish | 2017 |
Androgen- and estrogen-receptor mediated activities of 4-hydroxytestosterone, 4-hydroxyandrostenedione and their human metabolites in yeast based assays.
Topics: Androgens; Androstenedione; Biotransformation; Doping in Sports; Dose-Response Relationship, Drug; Estrogen Receptor alpha; Estrogens; Humans; Hydroxytestosterones; Molecular Docking Simulation; Performance-Enhancing Substances; Protein Conformation; Receptors, Androgen; Substance Abuse Detection; Testosterone Congeners; Yeasts | 2018 |
Acute exposure to 4-OH-A, not PCB
Topics: Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Brain; Chlorodiphenyl (54% Chlorine); Endocrine Disruptors; Larva; Zebrafish | 2019 |
Metabolism of formestane in humans: Identification of urinary biomarkers for antidoping analysis.
Topics: Administration, Oral; Adult; Androstenedione; Biomarkers; Doping in Sports; Humans; Male | 2019 |
The beneficial androgenic action of steroidal aromatase inactivators in estrogen-dependent breast cancer after failure of nonsteroidal drugs.
Topics: Androgens; Androstenedione; Animals; Anthracenes; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Female; Humans; Male; Mammary Neoplasms, Animal; MCF-7 Cells; Piperidines; Prostate; Protein Binding; Rats; RNA, Small Interfering; Seminal Vesicles; Steroids | 2019 |
Short-term aromatase inhibition induces prostatic alterations in adult wistar rat: A biochemical, histopathological and immunohistochemical study.
Topics: Amyloid; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Cell Proliferation; Gene Expression Regulation; Immunohistochemistry; Male; Prostate; Rats; Rats, Wistar; Time Factors; Tumor Suppressor Proteins | 2019 |
Role of human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C3) in the extrahepatic metabolism of the steroidal aromatase inactivator Formestane.
Topics: 20-Hydroxysteroid Dehydrogenases; 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); Administration, Oral; Aldo-Keto Reductase Family 1 Member C3; Androstenedione; Animals; Chlorocebus aethiops; COS Cells; Humans; Hydroxysteroid Dehydrogenases; Kinetics; Molecular Docking Simulation; Oxidoreductases; Protein Binding; Protein Isoforms; Recombinant Proteins; Solvents; Steroids | 2020 |
Investigating hormone-induced changes in affective state using the affective bias test in male and female rats.
Topics: Affect; Androstenedione; Animals; Behavior, Animal; Benzhydryl Compounds; Deamino Arginine Vasopressin; Estradiol; Female; Flutamide; Hormones; Male; Oxytocin; Phenols; Progesterone; Rats; Rats, Sprague-Dawley; Sex Factors; Testosterone | 2020 |
Developmental decrease in parvalbumin-positive neurons precedes increase in flurothyl-induced seizure susceptibility in the Brd2
Topics: Androstenedione; Animals; Disease Models, Animal; Female; Flurothyl; GABAergic Neurons; Male; Mice; Mice, Inbred C57BL; Myoclonic Epilepsy, Juvenile; Neurons; Parvalbumins; Seizures; Testosterone Propionate; Transcription Factors | 2020 |
In-depth gas chromatography/tandem mass spectrometry fragmentation analysis of formestane and evaluation of mass spectral discrimination of isomeric 3-keto-4-ene hydroxy steroids.
Topics: Androstenedione; Doping in Sports; Gas Chromatography-Mass Spectrometry; Steroids; Tandem Mass Spectrometry | 2020 |
Differentially expressed genes on the growth of mouse Leydig cells treated with standardised Eurycoma longifolia extract.
Topics: Adaptor Proteins, Signal Transducing; Androstenedione; Animals; Cell Line; Cell Survival; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Eurycoma; Gene Expression Regulation; Gene Regulatory Networks; Leydig Cells; Male; Mice; Phytochemicals; Plant Extracts; Proto-Oncogene Proteins c-cbl; Testosterone | 2020 |
Cardiac and Brainstem Neuroinflammatory Pathways Account for Androgenic Incitement of Cardiovascular and Autonomic Manifestations in Endotoxic Male Rats.
Topics: 5-alpha Reductase Inhibitors; Androstenedione; Animals; Aromatase Inhibitors; Autonomic Nervous System; Blood Pressure; Brain Stem; Disease Models, Animal; Encephalitis; Endotoxemia; Finasteride; Heart; Heart Diseases; Heart Rate; Inflammation Mediators; Male; Oligopeptides; Orchiectomy; Rats, Wistar; Receptors, LHRH; Testosterone | 2021 |
Dermal repeated dose toxicity study of the anti-breast cancer drug Formestane cream in Bama minipig.
Topics: Androstenedione; Animals; Antineoplastic Agents; Female; Neoplasms; Swine; Swine, Miniature | 2023 |