andrograpanin has been researched along with 14-deoxyandrographolide* in 1 studies
1 other study(ies) available for andrograpanin and 14-deoxyandrographolide
| Article | Year |
|---|---|
Microbial transformation of deoxyandrographolide and their inhibitory activity on LPS-induced NO production in RAW 264.7 macrophages.
A series of analogues of deoxyandrographolide (1) transformed by Cunninghamella blakesleana AS 3.2004 were isolated and identified by spectral methods including 2D NMR. Among them, 3-oxo-17,19-dihydroxy-7,13-ent-labdadien-15,16-olide (9), 3-oxo-19-hydroxy-1,13-ent-labdadien-15,16-olide (16), 3-oxo-1β-hydroxy-14-deoxy-andrographolide (17) and 3-oxo-2β-hydroxy-14-deoxyandrographolide (18) are new compounds. And their structure-activity relationships (SAR) of inhibitory activity on LPS-induced NO production in RAW 264.7 macrophage cells were also discussed. Topics: Cunninghamella; Diterpenes; Lipopolysaccharides; Macrophages; Magnetic Resonance Spectroscopy; Molecular Structure; Nitric Oxide; Structure-Activity Relationship | 2012 |