andrimid and octa-2-4-6-trienoic-acid

andrimid has been researched along with octa-2-4-6-trienoic-acid* in 1 studies

Other Studies

1 other study(ies) available for andrimid and octa-2-4-6-trienoic-acid

ArticleYear
A Biological Route to Conjugated Alkenes: Microbial Production of Hepta-1,3,5-triene.
    ACS synthetic biology, 2021, 02-19, Volume: 10, Issue:2

    Conjugated alkenes such as dienes and polyenes have a range of applications as pharmaceutical agents and valuable building blocks in the polymer industry. Development of a renewable route to these compounds provides an alternative to fossil fuel derived production. The enzyme family of the UbiD decarboxylases offers substantial scope for alkene production, readily converting poly unsaturated acids. However, biochemical pathways producing the required substrates are poorly characterized, and UbiD-application has hitherto been limited to biological styrene production. Herein, we present a proof-of-principle study for microbial production of polyenes using a bioinspired strategy employing a polyketide synthase (PKS) in combination with a UbiD-enzyme. Deconstructing a bacterial iterative type II PKS enabled repurposing the broad-spectrum antibiotic andrimid biosynthesis pathway to access the metabolic intermediate 2,4,6-octatrienoic acid, a valuable chemical for material and pharmaceutical industry. Combination with the fungal ferulic acid decarboxylase (Fdc1) led to a biocatalytic cascade-type reaction for the production of hepta-1,3,5-triene

    Topics: Anti-Bacterial Agents; Aspergillus niger; Biocatalysis; Carboxy-Lyases; Escherichia coli; Escherichia coli Proteins; Fatty Acids, Unsaturated; Fungal Proteins; Metabolic Engineering; Polyenes; Polyketide Synthases; Pyrroles

2021