an2728 and tavaborole
an2728 has been researched along with tavaborole* in 2 studies
Reviews
1 review(s) available for an2728 and tavaborole
| Article | Year |
|---|---|
Boron in drug design: Recent advances in the development of new therapeutic agents.
Topics: Animals; Boron Compounds; Bortezomib; Bridged Bicyclo Compounds, Heterocyclic; Dermatitis, Atopic; Drug Design; Humans; Multiple Myeloma; Onychomycosis | 2019 |
Other Studies
1 other study(ies) available for an2728 and tavaborole
| Article | Year |
|---|---|
An assessment of the genetic toxicology of novel boron-containing therapeutic agents.
Boron-containing compounds are being studied as potential therapeutic agents. As part of the safety assessment of these therapeutic agents, a battery of genetic toxicology studies was conducted. The battery included a bacterial reverse mutation (Ames) assay, an in vitro chromosome aberration assay in peripheral human lymphocytes, and an in vivo rat micronucleus study. The following compounds represent some of the boron-containing compounds that have been advanced to human clinical trials in various therapeutic areas. The borinic picolinate, AN0128, is an antibacterial compound with anti-inflammatory activity that has been studied in clinical trials for acne and the treatment of mild to moderate atopic dermatitis. AN2690 (tavaborole) is a benzoxaborole in Phase 3 clinical trials for the topical treatment of onychomycosis, a fungal infection of the toenails and fingernails. Another benzoxaborole derivative, AN2728, a phosphodiesterase-4 (PDE4) inhibitor, is in Phase 2 clinical trials for the treatment of atopic dermatitis. AN2898, also a PDE4 inhibitor, has been studied in clinical trials for atopic dermatitis and psoriasis. AN3365 is a leucyl-tRNA synthetase inhibitor that has been in clinical development for the treatment of various Gram-negative bacterial infections. These five representative compounds were negative in the three genotoxicity assays. Furthermore, AN2690 has been studied in mouse and rat 2-year bioassays and was not found to have any carcinogenic potential. These results demonstrate that it is possible to design boron-based therapeutic agents with no genetic toxicology liabilities. Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Boranes; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; DNA; Female; Humans; Male; Mice; Micronucleus Tests; Molecular Structure; Mutagenicity Tests; Pyridines; Rats; Rats, Sprague-Dawley | 2013 |