an2728 has been researched along with calcipotriene* in 1 studies
1 other study(ies) available for an2728 and calcipotriene
| Article | Year |
|---|---|
Design, synthesis and biological evaluation of novel benzoxaborole derivatives as potent PDE4 inhibitors for topical treatment of atopic dermatitis.
In this work, a series of structurally novel benzoxaborole derivatives were designed, synthesized and biologically evaluated as PDE4 inhibitors for battling atopic dermatitis (AD). Among them, the majority exhibited superior PDE4B inhibitory activities to that of the lead compound Crisaborole, an approved PDE4 inhibitor. In particular, 72, the most potent PDE4B inhibitor throughout this series, displayed 136-fold improved enzymatic activity (IC Topics: Animals; Boron Compounds; Calcitriol; Cyclic Nucleotide Phosphodiesterases, Type 4; Dermatitis, Atopic; Dose-Response Relationship, Drug; Drug Design; Edema; Female; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Molecular Structure; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 2021 |