amyloid-beta-peptides and piperidine

amyloid-beta-peptides has been researched along with piperidine* in 1 studies

Other Studies

1 other study(ies) available for amyloid-beta-peptides and piperidine

Article	Year
Piperidine-derived gamma-secretase modulators. Bioorganic & medicinal chemistry letters, 2010, Feb-01, Volume: 20, Issue:3 This Letter details the SAR of a novel series of piperidine-derived gamma-secretase modulators. Compound 10h was found to be a potent modulator in vitro, which on further profiling, was found to decrease Abeta42, increase Abeta38 and have no effect on Abeta40 levels. Furthermore, 10h demonstrated excellent pharmacokinetic parameters in the mouse, rat and dog in addition to good CNS penetration in the mouse. Topics: Acetates; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cell Line, Tumor; Dogs; Humans; Mice; Peptide Fragments; Piperidines; Rats; Structure-Activity Relationship; Substrate Specificity	2010

Article

Year

Piperidine-derived gamma-secretase modulators.

Bioorganic & medicinal chemistry letters, 2010, Feb-01, Volume: 20, Issue:3

This Letter details the SAR of a novel series of piperidine-derived gamma-secretase modulators. Compound 10h was found to be a potent modulator in vitro, which on further profiling, was found to decrease Abeta42, increase Abeta38 and have no effect on Abeta40 levels. Furthermore, 10h demonstrated excellent pharmacokinetic parameters in the mouse, rat and dog in addition to good CNS penetration in the mouse.

Topics: Acetates; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cell Line, Tumor; Dogs; Humans; Mice; Peptide Fragments; Piperidines; Rats; Structure-Activity Relationship; Substrate Specificity

2010