amyloid-beta-peptides has been researched along with phenylethyl-3-methylcaffeate* in 1 studies
1 other study(ies) available for amyloid-beta-peptides and phenylethyl-3-methylcaffeate
| Article | Year |
|---|---|
Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Abeta1-40 aggregation in vitro.
A series of N-terminus benzamides of glycine-based symmetric peptides, linked to m-xylylenediamine and 3,4'-oxydianiline spacers, were prepared and tested as inhibitors of beta-amyloid peptide Abeta(1-40) aggregation in vitro. Compounds with good anti-aggregating activity were detected. Polyphenolic amides showed the highest anti-aggregating activity, with IC(50) values in the micromolar range. Structure-activity relationships suggested that pi-pi stacking and hydrogen-bonding interactions play a key role in the inhibition of Abeta(1-40) self-assembly leading to amyloid fibrils. Topics: Amyloid beta-Peptides; Aniline Compounds; Benzamides; Caffeic Acids; Drug Design; Glycine; Molecular Structure; Peptide Fragments; Peptides; Phenyl Ethers; Stereoisomerism; Structure-Activity Relationship; Time Factors; Xylenes | 2008 |