amyloid-beta-peptides and panaxadiol

amyloid-beta-peptides has been researched along with panaxadiol* in 1 studies

Other Studies

1 other study(ies) available for amyloid-beta-peptides and panaxadiol

Article	Year
[Cortical neuron apoptosis induced by beta-amyloid peptide and protective effect of panoxadiol in mice]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2008, Volume: 37, Issue:5 To investigate the apoptosis of cortical neurons induced by beta-amyloid peptide (Abeta(1-40)) and the protective effect of panoxadiol.. The Abeta(1-40) induced damage of primarily cultured mouse cortical neurons was examined with morphological observation, MTT assay, DNA agarose gel electrophoresis and Western-blot.. After 48 h treated with 12 mumol/L Abeta(1-40), the cortical neurons showed apoptotic characteristics: including decreased OD570 value in MTT assay, DNA cleavage fragment in electrophoresis and increased apoptotic cells. Western-blot showed that the expression of bcl-2 reduced significantly (P<0.05). Cell apoptosis was significantly attenuated in 40 mg/L panoxadiol treated group.. Panoxadiol can protect cultured cortical neurons from apoptosis induced by Abeta(1-40) in mice. Topics: Amyloid beta-Peptides; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Drugs, Chinese Herbal; Female; Fetus; Ginsenosides; Mice; Mice, Inbred ICR; Neurons; Neuroprotective Agents; Peptide Fragments; Pregnancy; Proto-Oncogene Proteins c-bcl-2	2008

Article

Year

[Cortical neuron apoptosis induced by beta-amyloid peptide and protective effect of panoxadiol in mice].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2008, Volume: 37, Issue:5

To investigate the apoptosis of cortical neurons induced by beta-amyloid peptide (Abeta(1-40)) and the protective effect of panoxadiol.. The Abeta(1-40) induced damage of primarily cultured mouse cortical neurons was examined with morphological observation, MTT assay, DNA agarose gel electrophoresis and Western-blot.. After 48 h treated with 12 mumol/L Abeta(1-40), the cortical neurons showed apoptotic characteristics: including decreased OD570 value in MTT assay, DNA cleavage fragment in electrophoresis and increased apoptotic cells. Western-blot showed that the expression of bcl-2 reduced significantly (P<0.05). Cell apoptosis was significantly attenuated in 40 mg/L panoxadiol treated group.. Panoxadiol can protect cultured cortical neurons from apoptosis induced by Abeta(1-40) in mice.

Topics: Amyloid beta-Peptides; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Drugs, Chinese Herbal; Female; Fetus; Ginsenosides; Mice; Mice, Inbred ICR; Neurons; Neuroprotective Agents; Peptide Fragments; Pregnancy; Proto-Oncogene Proteins c-bcl-2

2008