amyloid-beta-peptides and albiflorin

amyloid-beta-peptides has been researched along with albiflorin* in 1 studies

Other Studies

1 other study(ies) available for amyloid-beta-peptides and albiflorin

Article	Year
Inhibition of β-amyloid Aggregation By Albiflorin, Aloeemodin And Neohesperidin And Their Neuroprotective Effect On Primary Hippocampal Cells Against β-amyloid Induced Toxicity. Current Alzheimer research, 2015, Volume: 12, Issue:5 Being one of the hallmarks of Alzheimer's disease, β-amyloid (Aβ) aggregates induce complicated neurotoxicity. Evidences show that the underlying mechanism of neurotoxicity involves a glutamate receptor subtype, N-methyl-D-aspartate (NMDA) receptor, an increase in intracellular calcium(II) ion loading as well as an elevation in oxidation stress. In this work, among the 35 chemical components of Chinese herbal medicines (CHMs) being screened for inhibitors of Aβ aggregation, four of them, namely albiflorin, aloeemodin, neohesperidin and physcion, were found for the first time to exhibit a potent inhibitory effect on Aβ(1-40) and Aβ(1-42) aggregation. Their neuroprotective capability on primary hippocampal neuronal cells was also investigated by MTT assay, ROS assay and intracellular calcium(II) ion concentration measurement. It was interesting to find that physcion was rather toxic to neuronal cells while albiflorin, aloeemodin and neohesperidin reduced the toxicity and ROS induced by both monomeric and oligomeric Aβ species. In addition, albiflorin was particularly powerful in maintaining the intracellular Ca(2+) concentration. Topics: Amyloid beta-Peptides; Animals; Bridged-Ring Compounds; Calcium; Cell Death; Cell Line, Tumor; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Emodin; Hesperidin; Hippocampus; Humans; Ions; Neurons; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats, Sprague-Dawley; Reactive Oxygen Species	2015

Article

Year

Inhibition of β-amyloid Aggregation By Albiflorin, Aloeemodin And Neohesperidin And Their Neuroprotective Effect On Primary Hippocampal Cells Against β-amyloid Induced Toxicity.

Current Alzheimer research, 2015, Volume: 12, Issue:5

Being one of the hallmarks of Alzheimer's disease, β-amyloid (Aβ) aggregates induce complicated neurotoxicity. Evidences show that the underlying mechanism of neurotoxicity involves a glutamate receptor subtype, N-methyl-D-aspartate (NMDA) receptor, an increase in intracellular calcium(II) ion loading as well as an elevation in oxidation stress. In this work, among the 35 chemical components of Chinese herbal medicines (CHMs) being screened for inhibitors of Aβ aggregation, four of them, namely albiflorin, aloeemodin, neohesperidin and physcion, were found for the first time to exhibit a potent inhibitory effect on Aβ(1-40) and Aβ(1-42) aggregation. Their neuroprotective capability on primary hippocampal neuronal cells was also investigated by MTT assay, ROS assay and intracellular calcium(II) ion concentration measurement. It was interesting to find that physcion was rather toxic to neuronal cells while albiflorin, aloeemodin and neohesperidin reduced the toxicity and ROS induced by both monomeric and oligomeric Aβ species. In addition, albiflorin was particularly powerful in maintaining the intracellular Ca(2+) concentration.

Topics: Amyloid beta-Peptides; Animals; Bridged-Ring Compounds; Calcium; Cell Death; Cell Line, Tumor; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Emodin; Hesperidin; Hippocampus; Humans; Ions; Neurons; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats, Sprague-Dawley; Reactive Oxygen Species

2015