amyloid-beta-peptides and acrylic-acid

amyloid-beta-peptides has been researched along with acrylic-acid* in 1 studies

Other Studies

1 other study(ies) available for amyloid-beta-peptides and acrylic-acid

Article	Year
Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160. Bioorganic & medicinal chemistry letters, 2020, 06-01, Volume: 30, Issue:11 Two new chlorinated secondary metabolites, saccharochlorines A and B (1 and 2), were isolated from the saline cultivation of a marine-derived bacterium Saccharomonospora sp. (KCTC-19160). The chemical structures of the saccharochlorines were elucidated by 2D NMR and MS spectroscopic data. Saccharochlorines A and B (1 and 2) exhibit weak inhibition of β-secretase (BACE1) in biochemical inhibitory assay, but they induced the release of Aβ (1-40) and Aβ (1-42) in H4-APP neuroglial cells. This discrepancy might be derived from the differences between the cellular and sub-cellular environments or the epigenetic stimulation of BACE1 expression. Topics: Acrylates; Actinobacteria; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Neuroglia; Peptide Fragments	2020

Article

Year

Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160.

Bioorganic & medicinal chemistry letters, 2020, 06-01, Volume: 30, Issue:11

Two new chlorinated secondary metabolites, saccharochlorines A and B (1 and 2), were isolated from the saline cultivation of a marine-derived bacterium Saccharomonospora sp. (KCTC-19160). The chemical structures of the saccharochlorines were elucidated by 2D NMR and MS spectroscopic data. Saccharochlorines A and B (1 and 2) exhibit weak inhibition of β-secretase (BACE1) in biochemical inhibitory assay, but they induced the release of Aβ (1-40) and Aβ (1-42) in H4-APP neuroglial cells. This discrepancy might be derived from the differences between the cellular and sub-cellular environments or the epigenetic stimulation of BACE1 expression.

Topics: Acrylates; Actinobacteria; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Neuroglia; Peptide Fragments

2020