amyloid-beta-peptides and 4-mercaptobenzoate

Chemical and physical properties of nanobio interface substantially affect the conformational transitions of adjacent biomolecules. Previous studies have reported the chiral effect and charge effect of nanobio interface on the misfolding, aggregation, and fibrillation of amyloid protein. However, the isomeric effect of nanobio interface on protein/peptides amyloidosis is still unclear. Here, three isomeric nanobio interfaces were designed and fabricated based on the same sized gold nanoclusters (AuNCs) modified with 4-mercaptobenzoic acid (

Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzoates; Gold; Humans; Isomerism; Metal Nanoparticles; Peptide Fragments; Protein Aggregates; Protein Folding; Salicylates; Sulfhydryl Compounds