amsacrine and verapamil

amsacrine has been researched along with verapamil in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's3 (25.00)18.2507
2000's3 (25.00)29.6817
2010's3 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Sen, S; Sinha, N1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Cattan, AR; Davies, SM; Hall, AG; Harris, AL; Hickson, ID; Hoban, PR; Robson, CN1
de Jong, S; de Vries, EG; Mulder, NH; Zijlstra, JG1
Darkin, S; Ralph, RK1
Baguley, BC; Ferguson, LR1
Andersson, BS; Beran, M; Mavligit, GM; McCredie, KB; Stuckey, SE1
Baguley, BC; Davey, MW; Davey, RA; Hargrave, RM; Harvie, RM; Su, GM1

Other Studies

12 other study(ies) available for amsacrine and verapamil

ArticleYear
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
    Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4

    Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Reduced topoisomerase II and elevated alpha class glutathione S-transferase expression in a multidrug resistant CHO cell line highly cross-resistant to mitomycin C.
    Biochemical pharmacology, 1992, Feb-18, Volume: 43, Issue:4

    Topics: Amsacrine; Animals; CHO Cells; Colony-Forming Units Assay; Cricetinae; Daunorubicin; DNA Damage; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Gene Expression; Glutathione Transferase; Humans; Hybrid Cells; Infant, Newborn; Mitomycin; Verapamil

1992
Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line.
    Cancer research, 1990, Jan-15, Volume: 50, Issue:2

    Topics: Amsacrine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Cell Cycle; Cell Division; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Etoposide; Humans; Lung Neoplasms; Membrane Glycoproteins; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Verapamil

1990
Potentiation of 4'-(9-acridinylamino)methanesulphon-m-anisidine) action by verapamil.
    Cancer letters, 1986, Volume: 30, Issue:1

    Topics: Aminoacridines; Amsacrine; Animals; Cell Line; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Mast-Cell Sarcoma; Mice; Structure-Activity Relationship; Verapamil

1986
Verapamil modulates mutagenicity of antitumour acridines in bacteria and yeast.
    Biochemical pharmacology, 1986, Dec-15, Volume: 35, Issue:24

    Topics: Acridines; Amsacrine; Animals; Cell Line; Doxorubicin; Drug Resistance; Leukemia, Experimental; Mice; Mutagenicity Tests; Saccharomyces cerevisiae; Salmonella typhimurium; Verapamil

1986
Sensitivity and resistance to chemotherapy in acute leukemia: correlation with in vitro drug uptake and lack of potentiation by verapamil.
    Medical oncology and tumor pharmacotherapy, 1987, Volume: 4, Issue:1

    Topics: Acute Disease; Adult; Aged; Amsacrine; Cells, Cultured; Doxorubicin; Drug Resistance; Drug Synergism; Female; Humans; Leukemia; Male; Middle Aged; Verapamil

1987
The potential of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide to circumvent three multidrug-resistance phenotypes in vitro.
    Cancer chemotherapy and pharmacology, 1997, Volume: 39, Issue:5

    Topics: Acridines; Amsacrine; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Line; Cell Survival; Daunorubicin; Drug Resistance, Multiple; HL-60 Cells; Humans; Idarubicin; Leukemia; Paclitaxel; Phenotype; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Verapamil

1997