amsacrine and novobiocin

amsacrine has been researched along with novobiocin in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199014 (41.18)18.7374
1990's16 (47.06)18.2507
2000's0 (0.00)29.6817
2010's4 (11.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, IH; Jun, KY; Kwon, Y; Lee, E; Lee, ES; Na, Y; Park, SE1
Kulkarni, P; Meda, N; Medapi, B; Sriram, D; Yogeeswari, P1
Bist, G; Jun, KY; Kadayat, TM; Kwon, Y; Lee, ES; Park, S; Shrestha, A; Thapa Magar, TB1
Constantinou, A; Grdina, D; Huberman, E; Kiguchi, K1
DeMarini, DM; Lawrence, BK2
Lorico, A; Rappa, G; Sartorelli, AC1
Adachi, K; Andrea, JE; Morgan, AR1
Aller, P; Bernabeu, C; Cabañas, C; Mata, F; Rius, C; Zorrilla, AR1
Buddenbaum, WE; Don, AL; Elkind, MM; Kosaka, T; Shibuya, ML; Suciu, D; Utsumi, H1
Lyons, BW; Warters, RL1
Buddenbaum, WE; Elkind, MM; Kosaka, T; Shibuya, ML; Utsumi, H1
Elkind, MM; Shibuya, ML; Utsumi, H1
Alnemri, ES; Litwack, G1
Kort, L; Rowley, R1
Constantinou, A; Henning-Chubb, C; Huberman, E1
Kennedy, K; Li, TM; Lyons, BW; Warters, RL1
Denyer, SP; Dewick, PM; Figgitt, DP; Jackson, DE; Williams, P1
Boyce, RA; Hertzberg, RP; Mattern, MR; Schein, PS; Tan, KB1
Beerman, TA; Sigmund, RD; Woynarowski, JM1
Ishida, R; Nishimoto, T; Nishizawa, M; Takahashi, T1
Besterman, J; Chang, KJ; Cuatrecasas, P; Hsieh, T; LeVine, H; Sahyoun, N; Sander, M; Wolf, M1
Doida, Y; Fero, ML; Guo, XC; Morgan, WF; Shadley, JD1
Mui, SC; Strauss, PR; Todt, JC; Zhang, LH1
Denstman, SC; Dillehay, LE; Williams, JR1
Darkin, S; Marshall, B; Ralph, RK1
Kohn, KW; Mattern, MR; Pommier, Y; Schwartz, RE; Zwelling, LA1
Sitailo, LA; Zagariya, AM1
Corbett, AH; Osheroff, N; Robinson, MJ1
Corbett, AH; Hong, D; Osheroff, N1
Jo, K; Topal, MD1
Falaschi, A; Ochem, A; Phan, TN; Tuteja, N; Tuteja, R1
Phan, TN; Tuteja, N1

Other Studies

34 other study(ies) available for amsacrine and novobiocin

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase IIα catalytic inhibitor with low DNA damage.
    European journal of medicinal chemistry, 2013, Volume: 69

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Biocatalysis; Cell Line, Tumor; Cell Proliferation; DNA Damage; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Structure-Activity Relationship; Topoisomerase II Inhibitors; Xanthones

2013
Development of acridine derivatives as selective Mycobacterium tuberculosis DNA gyrase inhibitors.
    Bioorganic & medicinal chemistry, 2016, Feb-15, Volume: 24, Issue:4

    Topics: Acridines; Animals; Antitubercular Agents; Bacterial Proteins; Cell Line; Cell Survival; Chlorobenzoates; DNA Gyrase; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Ether-A-Go-Go Potassium Channels; Gene Expression; Heart Rate; Macrophages; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Piperidines; Quinolines; Structure-Activity Relationship; Topoisomerase II Inhibitors; Zebrafish; Zebrafish Proteins

2016
Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors.
    European journal of medicinal chemistry, 2017, Jan-05, Volume: 125

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Humans; Molecular Docking Simulation; Pyridines; Structure-Activity Relationship; Topoisomerase II Inhibitors

2017
The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in human K-562 leukemia cells.
    Experimental cell research, 1992, Volume: 203, Issue:1

    Topics: Amsacrine; Aphidicolin; Cell Cycle; Cell Differentiation; Cycloheximide; Deoxyadenosines; Dose-Response Relationship, Drug; Etoposide; G2 Phase; Hemoglobins; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Melanins; Mitosis; Novobiocin; Teniposide; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1992
Prophage induction by DNA topoisomerase II poisons and reactive-oxygen species: role of DNA breaks.
    Mutation research, 1992, Volume: 267, Issue:1

    Topics: Amsacrine; Azides; Bacteriophage lambda; Dactinomycin; DNA Damage; Dose-Response Relationship, Drug; Doxorubicin; Ellipticines; Escherichia coli; Free Radicals; Hydrogen Peroxide; Lysogeny; Nalidixic Acid; Novobiocin; Oxolinic Acid; Oxygen; Paraquat; Sodium Azide; SOS Response, Genetics; Teniposide; Topoisomerase II Inhibitors; Virus Replication

1992
Potentiation by novobiocin of the cytotoxic activity of etoposide (VP-16) and teniposide (VM-26).
    International journal of cancer, 1992, Jul-09, Volume: 51, Issue:5

    Topics: Adenocarcinoma; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; DNA; DNA Topoisomerases, Type II; Drug Synergism; Etoposide; Humans; Leukemia; Lung Neoplasms; Novobiocin; RNA; Teniposide; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1992
Fluorometric assays for DNA topoisomerases and topoisomerase-targeted drugs: quantitation of catalytic activity and DNA cleavage.
    Molecular pharmacology, 1991, Volume: 40, Issue:4

    Topics: Amsacrine; Animals; Antineoplastic Agents; Camptothecin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Circular; DNA, Single-Stranded; DNA, Superhelical; Ethidium; Fluorescence; Fluorometry; Hydrogen-Ion Concentration; Kinetics; Novobiocin; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1991
Differentiation of human promonocytic leukemia U-937 cells with DNA topoisomerase II inhibitors: induction of vimentin gene expression.
    Molecular pharmacology, 1991, Volume: 39, Issue:4

    Topics: Amsacrine; Antigens, Differentiation; Cell Differentiation; Cell Division; Etoposide; Gene Expression Regulation, Leukemic; Humans; Leukemia, Monocytic, Acute; Novobiocin; Oxygen; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Vimentin

1991
Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol.
    Cancer research, 1991, Jan-15, Volume: 51, Issue:2

    Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Amsacrine; Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dinitrophenols; DNA; DNA Damage; DNA, Single-Stranded; Kinetics; Novobiocin

1991
Inhibition of replicon cluster ligation into chromosomal DNA at elevated temperatures.
    Journal of cellular physiology, 1990, Volume: 142, Issue:2

    Topics: Amsacrine; Caffeine; Chromatin; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Replication; DNA, Single-Stranded; HeLa Cells; Histones; Hot Temperature; Humans; Hydrogen-Ion Concentration; Micrococcal Nuclease; Novobiocin; Replicon; Topoisomerase II Inhibitors

1990
Abrogation by novobiocin of cytotoxicity due to the topoisomerase II inhibitor amsacrine in Chinese hamster cells.
    Cancer research, 1990, May-01, Volume: 50, Issue:9

    Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Amsacrine; Animals; Cell Survival; Cells, Cultured; Cricetinae; Dinitrophenols; DNA; DNA Repair; Novobiocin; Proteins; Topoisomerase II Inhibitors

1990
Novobiocin inhibits the repair of potentially lethal damage but not the repair of sublethal damage.
    Radiation research, 1990, Volume: 123, Issue:1

    Topics: Amsacrine; Animals; Cell Line; Cricetinae; DNA Damage; DNA Repair; Etoposide; Novobiocin; Teniposide; Topoisomerase II Inhibitors

1990
Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s).
    The Journal of biological chemistry, 1990, Oct-05, Volume: 265, Issue:28

    Topics: Amsacrine; Calcium; Cell Division; Cell Line; Cell Survival; Chromatin; DNA; DNA, Neoplasm; Humans; Lymphocytes; Models, Biological; Novobiocin; Nucleosomes; Topoisomerase II Inhibitors; Triamcinolone Acetonide

1990
Novobiocin, nalidixic acid, etoposide, and 4'-(9-acridinylamino)methanesulfon-m-anisidide effects on G2 and mitotic Chinese hamster ovary cell progression.
    Cancer research, 1989, Sep-01, Volume: 49, Issue:17

    Topics: Amsacrine; Animals; Cell Line; Cell Survival; DNA Damage; Etoposide; Interphase; Metaphase; Mitosis; Nalidixic Acid; Novobiocin; RNA; Topoisomerase II Inhibitors

1989
Novobiocin- and phorbol-12-myristate-13-acetate-induced differentiation of human leukemia cells associated with a reduction in topoisomerase II activity.
    Cancer research, 1989, Mar-01, Volume: 49, Issue:5

    Topics: Amsacrine; Cell Differentiation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Humans; Leukemia, Promyelocytic, Acute; Novobiocin; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate

1989
Topoisomerase activity in irradiated mammalian cells.
    Mutation research, 1989, Volume: 216, Issue:1

    Topics: Amsacrine; Caffeine; Cell Survival; DNA Damage; DNA Repair; DNA Topoisomerases, Type I; DNA, Mitochondrial; Dose-Response Relationship, Radiation; HeLa Cells; Humans; Intercalating Agents; Novobiocin; X-Rays

1989
Topoisomerase II: a potential target for novel antifungal agents.
    Biochemical and biophysical research communications, 1989, Apr-14, Volume: 160, Issue:1

    Topics: Amiloride; Amsacrine; Antifungal Agents; DNA, Superhelical; Etoposide; Molecular Structure; Novobiocin; Plasmids; Podophyllotoxin; Saccharomyces cerevisiae; Structure-Activity Relationship; Topoisomerase II Inhibitors

1989
Elevated topoisomerase II activity and altered chromatin in nitrogen mustard-resistant human cells.
    NCI monographs : a publication of the National Cancer Institute, 1987, Issue:4

    Topics: Amsacrine; Burkitt Lymphoma; Cell Line; Cell Survival; Chromatin; DNA Topoisomerases, Type II; Drug Resistance; Humans; Kinetics; Mechlorethamine; Novobiocin; Podophyllotoxin; Teniposide; Tumor Stem Cell Assay

1987
Topoisomerase-II-mediated lesions in nascent DNA: comparison of the effects of epipodophyllotoxin derivatives, VM-26 and VP-16, and 9-anilinoacridine derivatives, m-AMSA and o-AMSA.
    Biochimica et biophysica acta, 1988, May-06, Volume: 950, Issue:1

    Topics: Adenosine Triphosphate; Amsacrine; Animals; Cross-Linking Reagents; DNA; DNA Damage; DNA Replication; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Leukemia L1210; Mice; Novobiocin; Podophyllotoxin; Teniposide; Topoisomerase II Inhibitors

1988
Cross-resistance of novobiocin-resistant BHK cell line to topoisomerase II inhibitors.
    Somatic cell and molecular genetics, 1988, Volume: 14, Issue:5

    Topics: Amsacrine; Animals; Cell Line; Colchicine; Cytarabine; DNA Damage; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Novobiocin; Podophyllotoxin; Vinblastine

1988
Mutagenicity of topoisomerase-active agents in bacteriophage T4.
    Teratogenesis, carcinogenesis, and mutagenesis, 1988, Volume: 8, Issue:5

    Topics: Amsacrine; Dactinomycin; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Doxorubicin; Ellipticines; Mutation; Nalidixic Acid; Novobiocin; Oxolinic Acid; T-Phages

1988
Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:6

    Topics: Aminoacridines; Amsacrine; Animals; Cell Differentiation; Cell Line; DNA Topoisomerases, Type II; Drosophila melanogaster; Enzyme Activation; Kinetics; Leukemia, Myeloid, Acute; Male; Novobiocin; Phorbol Esters; Phosphorylation; Phosphoserine; Protein Kinase C; Protein Kinases; Rats; Rats, Inbred Strains; Topoisomerase II Inhibitors

1986
Potentiation of sister chromatid exchange by 3-aminobenzamide is not modulated by topoisomerases or proteases.
    Environmental mutagenesis, 1986, Volume: 8, Issue:4

    Topics: Aminoacridines; Amsacrine; Animals; Antipain; Benzamides; Cricetinae; Cricetulus; DNA Topoisomerases, Type I; Female; Methyl Methanesulfonate; Nalidixic Acid; Novobiocin; Peptide Hydrolases; Poly(ADP-ribose) Polymerases; Sister Chromatid Exchange

1986
Role for topoisomerases in the release of DNA into the detergent-soluble fraction of eukaryotic cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:16

    Topics: Aminoacridines; Amsacrine; Animals; Camptothecin; Detergents; DNA; DNA Topoisomerases, Type I; Intercalating Agents; Kinetics; Mice; Novobiocin; Solubility; Spleen; Teniposide; Thymidine

1986
Cell cycle dependence of sister chromatid exchange induction by DNA topoisomerase II inhibitors in Chinese hamster V79 cells.
    Cancer research, 1987, Jan-01, Volume: 47, Issue:1

    Topics: Amsacrine; Cell Cycle; Cell Line; DNA; Flow Cytometry; Novobiocin; Sister Chromatid Exchange; Topoisomerase II Inhibitors

1987
Evidence that mAMSA induces topoisomerase action.
    FEBS letters, 1983, Sep-05, Volume: 161, Issue:1

    Topics: Aminoacridines; Aminocoumarins; Amsacrine; Animals; Cell Line; Cell Nucleus; Coumarins; DNA Topoisomerases, Type I; DNA, Neoplasm; Intercalating Agents; Kinetics; Mast-Cell Sarcoma; Mice; Novobiocin; Sarcoma, Experimental

1983
Changes in deoxyribonucleic acid linking number due to treatment of mammalian cells with the intercalating agent 4'-(9-acridinylamino)methanesulfon-m-anisidide.
    Biochemistry, 1984, Jun-19, Volume: 23, Issue:13

    Topics: Aminoacridines; Amsacrine; Animals; Benzamides; Cell Nucleus; Deoxyribonucleoproteins; DNA, Neoplasm; Ethidium; Intercalating Agents; Kinetics; Leukemia L1210; Mice; Novobiocin

1984
The influence of antibiotics and antitumor agents on the relaxation activity of Pisum sativum leaf chloroplast topoisomerase I.
    Archives of biochemistry and biophysics, 1995, Jun-20, Volume: 320, Issue:1

    Topics: Amiloride; Amsacrine; Anti-Bacterial Agents; Antineoplastic Agents; Camptothecin; Chloroplasts; DNA Topoisomerases, Type I; DNA, Plant; Ethidium; Heparin; Indoles; Magnesium; Nalidixic Acid; Novobiocin; Pisum sativum; Polyamines; Topoisomerase I Inhibitors

1995
Effects of topoisomerase II-targeted drugs on enzyme-mediated DNA cleavage and ATP hydrolysis: evidence for distinct drug interaction domains on topoisomerase II.
    Biochemistry, 1993, Apr-13, Volume: 32, Issue:14

    Topics: Adenosine Triphosphate; Amsacrine; Animals; Anti-Infective Agents; Antineoplastic Agents; Binding Sites; Cell Nucleus; DNA Topoisomerases, Type II; DNA, Bacterial; Drosophila melanogaster; Escherichia coli; Etoposide; Fluoroquinolones; Genistein; Hydrolysis; Isoflavones; Novobiocin; Plasmids; Quercetin; Quinolones; Topoisomerase II Inhibitors

1993
Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase II. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzyme.
    The Journal of biological chemistry, 1993, Jul-05, Volume: 268, Issue:19

    Topics: Amsacrine; Animals; Anti-Infective Agents; Binding Sites; Cell Line; Cell Nucleus; DNA; DNA Topoisomerases, Type II; DNA, Superhelical; Drosophila melanogaster; Drug Interactions; Etoposide; Fluoroquinolones; Genistein; Growth Inhibitors; Isoflavones; Kinetics; Novobiocin; Protein Binding; Quinolones; Structure-Activity Relationship; Topoisomerase II Inhibitors

1993
Changing a leucine to a lysine residue makes NaeI endonuclease hypersensitive to DNA intercalative drugs.
    Biochemistry, 1996, Aug-06, Volume: 35, Issue:31

    Topics: Amsacrine; Antineoplastic Agents; Binding Sites; Daunorubicin; Deoxyribonuclease EcoRI; Deoxyribonucleases, Type II Site-Specific; DNA Nucleotidyltransferases; DNA Topoisomerases, Type I; Ellipticines; Enzyme Inhibitors; Integrases; Intercalating Agents; Kinetics; Lysine; Nalidixic Acid; Novobiocin; Oxolinic Acid; Point Mutation; Recombinant Proteins; Recombinases; Topoisomerase I Inhibitors

1996
Inhibition of DNA unwinding and ATPase activities of human DNA helicase II by chemotherapeutic agents.
    Biochemical and biophysical research communications, 1997, Jul-30, Volume: 236, Issue:3

    Topics: Adenosine Triphosphatases; Amsacrine; Antineoplastic Agents; Aphidicolin; Camptothecin; Dactinomycin; Daunorubicin; DNA; DNA Helicases; Ellipticines; Enzyme Inhibitors; Ethidium; Etoposide; Genistein; Humans; Isoflavones; Nogalamycin; Novobiocin; Topoisomerase I Inhibitors

1997
Inhibition of pea chloroplast DNA helicase unwinding and ATPase activities by DNA-interacting ligands.
    Biochemical and biophysical research communications, 1998, Mar-27, Volume: 244, Issue:3

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amsacrine; Camptothecin; Chloroplasts; Dactinomycin; Daunorubicin; DNA Helicases; Ellipticines; Ethidium; Etoposide; Genistein; Hydrolysis; Intercalating Agents; Ligands; Nogalamycin; Novobiocin; Pisum sativum

1998