amsacrine and mitoxantrone

amsacrine has been researched along with mitoxantrone in 99 studies

Research

Studies (99)

Timeframe	Studies, this research(%)	All Research%
pre-1990	20 (20.20)	18.7374
1990's	43 (43.43)	18.2507
2000's	26 (26.26)	29.6817
2010's	10 (10.10)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Denny, WA; Feigon, J; Kearns, DR; Leupin, W	1
Barrows, LR; Clardy, J; Concepción, GP; Eldredge, GS; Foderaro, TA; Ireland, CM; Lobkovsky, E	1
Barrows, LR; Eldredge, GS; Ireland, CM; McDonald, LA	1
Baguley, BC; Deady, LW; Denny, WA; Rodemann, T; Zhuang, L	1
Bu, X; Eleftheriou, A; Hayek, C; Parmar, A; Stewart, BW; Wakelin, LP	1
Flanagan, JU; Kemp, CA; Maréchal, JD; Paine, MJ; Roberts, GC; Sutcliffe, MJ; van Eldik, AJ; Wolf, CR	1
Austin, CA; Curtis, H; Gilroy, KL; Jobson, A; López-Lázaro, M; Padget, K; Willmore, E	1
Lombardo, F; Obach, RS; Waters, NJ	1
Bollini, M; Bruno, AM; Casal, JJ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Benfenati, E; Raska, I; Toropov, AA; Toropova, AP	1
Aravena, Mde L; Bruno, AM; Cabrera, M; Cascante, M; Cerecetto, H; González, M; Lavaggi, ML; López de Ceráin, A; Monge, A; Olea-Azar, C; Pachón, G; Pietrasanta, LI	1
Cabrera, M; Cerecetto, H; González, M; Lavaggi, ML; López de Ceráin, A; Monge, A; Nieves, M; Olea-Azar, C	1
Godlewska, J; Kaczmarek, L; Luniewski, W; Peczynska-Czoch, W; Piskozub, M; Switalska, M; Wietrzyk, J	1
Sumner, AT	3
Legrand, O; Marie, JP; Russo, D; Suberville, AM; Zhou, D; Zittoun, R	1
Berman, E	1
Alessandrino, EP; Bacigalupo, A; Bernasconi, C; Carella, AM; Ficarra, F; Lazzarino, M; Locatelli, F; Morra, E; Pagnucco, G; Resegotti, L	1
Gray, RG; Rees, JK	1
Gilbert, KS; Griswold, DP; Harrison, SD; Laster, WR; Waud, WR	1
Bastida Vila, P; Giralt López, J; Javier Manchón, G; Olivé Oliveras, T; Ortega Aramburu, JJ; Sánchez, C	1
Granada, I; Las Heras, G; Millá, F; Ribera, JM	1
Darzynkiewicz, Z; Del Bino, G	1
Bell, SM; Dee, A; Smith, PJ; Sykes, H	1
Fox, ME; Smith, PJ	1
Bosly, A; Chatelain, C; Delannoy, A; Doyen, C; Ferrant, A; Ghilain, JM; Martiat, P; Michaux, JL; Sokal, G	1
Amess, J; Davis, CL; Lim, J; Lister, TA; Rohatiner, AZ	1
Broustet, A; Cony, P; Duclos, F; Marit, G; Puntous, M; Reiffers, J	1
Cunningham, M	1
Besserer, JA; Boritzki, TJ; Fry, DW; Jackson, RC	1
Davies, SL; Davies, SM; Harris, AL; Hickson, ID	1
Arlin, ZA	1
Epstein, RJ; Smith, PJ	1
Ganapathi, R; Grabowski, D; Israel, M; Schmidt, H; Seshadri, R	1
Glisson, B; Gupta, R; Hodges, P; Ross, W	1
Estey, E; Freireich, EJ; Kantarjian, HM; Keating, MJ; McCredie, KB; Smith, T; Walters, R	1
Falkson, G; Iturralde, MP; Vorobiof, DA	1
Berger, NA; Lazarus, HM	1
Amadori, S; Avvisati, G; Mandelli, F; Meloni, G; Petti, MC; Tafuri, A	1
Bishop, J; Coates, AS; Mann, GJ; Raghavan, D	1
Ogawa, M	2
Bleumink, AR; Jensen, CG; Wilson, WR	1
Gahrton, G	1
Davies, KJ; Doroshow, JH	1
Herman, TS	1
Corbett, TH; Griswold, DP; Roberts, BJ; Schabel, FM	1
Bruno, S; Macdonald, JS; Marsoni, S; Poster, D	1
Welborn, JL	1
Fridborg, H; Killander, A; Kristensen, J; Larsson, R; Liliemark, J; Nygren, P; Oberg, G; Simonsson, B	1
Carmichael, J; Greenall, M; Harris, AL; Houlbrook, S; Smith, K	1
Behrens, CH; Behrens, DL; Chen, SF; Fredericks, JR; Kirshenbaum, MR; Papp, LM; Polkus, ST; Sipple, P; Stafford, MM; Sun, JH	1
Perilov, AA; Poddubnaia, IV	1
Daenen, S; Huijgens, PC; Löwenberg, B; Sonneveld, P; van Putten, WL; van Veldhoven, M; Verdonck, LF; Verhoef, G	1
Delmer, A; Marie, JP; Suberville, AM; Thevenin, D; Zittoun, R	1
Bigioni, M; Capranico, G; De Isabella, P; Tinelli, S; Zunino, F	1
Elonen, E; Jokipii, A; Lautenschlager, I; Lyytikäinen, O; Ruutu, P; Tiittanen, L	1
Baruchel, A; Bergeron, C; Bordigoni, P; Esperou-Bourdeau, H; Landman-Parker, J; Leblanc, T; Leverger, G; Michel, G; Nelken, B; Perel, Y; Schaison, G; Thuret, I; Vannier, JP	1
Fey, MF; Hardegger, TP; Tobler, A; von Rohr, A	1
Huismans, DR; Klumper, E; Loonen, AH; Ossenkoppele, GJ; Pieters, R; Rottier, A; Veerman, AJ; Westra, G	1
Bailly, C; Minnock, A; Waring, MJ	1
de Vries, EG; Keith, WN; Mulder, NH; Nienhuis, EF; Uges, DR; van der Graaf, WT; Withoff, S	1
Ganapathi, R; Grabowski, D	1
Corbett, AH; Osheroff, N; Robinson, MJ	1
Dekker, AW; Haak, HL; Huijgens, PC; Löwenberg, B; Ossenkoppele, G; Schouten, HC; Sizoo, W; Sonneveld, P; van der Lelie, J; van Putten, WL; van't Veer, MB; Verdonck, LF; Willemze, R	1
Brinch, L; Evensen, SA; Hedenus, M; Hörnsten, P; Oberg, G; Simonsson, B; Wahlin, A	1
Gray, RG; Hann, IM; Stevens, RF; Wheatley, K	1
Akan, H; Arat, M; Arslan, O; Beksaç, M; Gürman, G; Ilhan, O; Koç, H; Konuk, N; Ozcan, M; Uysal, A	1
Avramis, VI; Carcich, S; Ortega, JA; Ozkaynak, MF	1
Lehman, S; Löfgren, C; Möllgård, L; Paul, C; Sundman-Engberg, B; Tidefelt, U	1
Feliu, E; Hernández, JA; Millá, F; Navarro, JT; Oriol, A; Pujol, M; Ribera, JM; Sancho, JM	1
Austin, CA; Baguley, BC; Errington, F; Li, G; Li, L; Li, W; Tilby, MJ; Willmore, E	1
Abgrall, JF; Audhuy, B; Casassus, P; Deconinck, E; Delain, M; Desablens, B; Guilhot, F; Guyotat, D; Harousseau, JL; Hunault-Berger, M; Le Prise, PY; Lioure, B; Solary, E; Tournilhac, O; Vilque, JP; Witz, B	1
Baguley, BC; Finlay, GJ	1
Hsieh, TS; Hu, T; Liu, LF; Mao, Y; Wang, H; Zhou, N	1
Hokland, P; Langkjer, ST; Nørgaard, JM; Palshof, T; Pedersen, B	1
Fojo, T; Matsumoto, Y; Nagao, S; Takano, H	1
Creutzig, U; de Vries, E; Hählen, K; Huismans, DR; Janka-Schaub, GE; Jansen, G; Kaspers, GJ; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ; Zwaan, CM	1
Bendix, K; Hokland, P; Kjeldsen, E; Kristensen, JS; Meyer, K; Nørgaard, JM; Olesen, G; Olesen, LH; Pedersen, B	1
Auvrignon, A; Bader-Meunier, B; Baruchel, A; Couillaud, G; Dalle, JH; De Lumley, L; Gandemer, V; Lamagnere, JP; Landman-Parker, J; Leblanc, T; Leverger, G; Michel, G; Nelken, B; Perel, Y; Schaison, G; Schmitt, C; Thuret, I; Vannier, JP	1
Kreuzer, KN; O'Reilly, EK	1
Andersson, PO; Brune, M; Gustavsson, B; Stockelberg, D; Wadenvik, H; Wernstedt, P	1
Austin, CA; Errington, F; Leontiou, C; Tilby, MJ; Willmore, E	1
Auvrignon, A; Baruchel, A; Couillaud, G; Dalle, JH; Gandemer, V; Lamagnere, JP; Leblanc, T; Leverger, G; Mèchinaud, F; Michel, G; Pautard, B; Perel, Y; Piguet, Ch; Schmitt, C; Vannier, JP	1
Kalaycio, M	1
Austin, CA; Ayuso, MJ; Azrak, SS; Cortés, F; López-Lázaro, M; Pastor, N	1
de Graaf, SS; Gibson, BE; Hann, IM; Hills, RK; O'Marcaigh, A; Rao, A; Stiller, C; Webb, DK; Wheatley, K	1
Aung, L; Kirk, RC; Liang, S; Quah, TC; Tan, RM; Yeoh, AE	1
Arnaud, P; Botton, Sd; Bourhis, JH; Castaigne, S; Cordonnier, C; Corront, B; de Revel, T; Dombret, H; Elhamri, M; Fenaux, P; Gardin, C; Le, QH; Michallet, M; Pautas, C; Preudhomme, C; Quesnel, B; Raffoux, E; Reman, O; Terré, C; Thomas, X	1
Hait, WN; Nayak, MS; Yang, JM	1
de Bont, ES; Kamps, WA; Koetse, HA; Rings, EH; Stellaard, F; Tissing, WJ; van Vliet, MJ	1
Aulitzky, W; Baldus, CD; Berdel, WE; Bornhäuser, M; Ehninger, G; Einsele, H; Hänel, M; Ho, AD; Illmer, T; Kramer, M; Krause, SW; Mayer, J; Neubauer, A; Parmentier, S; Röllig, C; Schäfer-Eckart, K; Schaich, M; Schetelig, J; Schmitz, N; Serve, H; Stölzel, F; Thiede, C	1
Chan, NL; Li, TK; Li, YC; Wang, YR; Wu, CC	1
Capranico, G; Gandin, V; Gianoncelli, A; Marzano, C; Palumbo, M; Pasquale, R; Ribaudo, G; Sissi, C; Zagotto, G	1
Cortes, JE; Feldman, EJ; Goldberg, SL; Hogge, DE; Kantarjian, H; Kolitz, JE; Larson, M; Louie, AC; Pigneux, A; Recher, C; Rizzeri, DA; Schiller, G; Warzocha, K	1
Farsani, FM; Ganjalikhany, MR; Vallian, S	1

Reviews

8 review(s) available for amsacrine and mitoxantrone

Article	Year
New drugs in acute myelogenous leukemia: a review. Journal of clinical pharmacology, 1992, Volume: 32, Issue:4 Topics: Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Cytarabine; Daunorubicin; Drug Evaluation; Humans; Idarubicin; Isomerism; Leukemia, Myeloid, Acute; Mitoxantrone; Remission Induction; Survival Rate; Tretinoin	1992
Nonhematologic toxicities of selected chemotherapeutic agents used in the treatment of adult leukemia. Seminars in oncology nursing, 1990, Volume: 6, Issue:1 Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Humans; Leukemia; Mitoxantrone; Nursing Assessment	1990
Mitoxantrone and amsacrine: two important agents for the treatment of acute myelogenous leukemia (AML) and acute lymphoblastic leukemia (ALL). Bone marrow transplantation, 1989, Volume: 4 Suppl 1 Topics: Amsacrine; Daunorubicin; Drug Evaluation; Humans; Leukemia, Myeloid, Acute; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction	1989
Chemotherapy of malignant disease: an update. Comprehensive therapy, 1988, Volume: 14, Issue:5 Topics: Amsacrine; Antineoplastic Agents; Cisplatin; Coformycin; Etoposide; Female; Humans; Ifosfamide; Male; Mitoxantrone; Neoplasms; Pentostatin; Pregnancy	1988
[Current status of clinical results of new antitumor drugs]. Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:2 Topics: Aminoacridines; Amsacrine; Anthracyclines; Anthraquinones; Antibiotics, Antineoplastic; Antineoplastic Agents; Aziridines; Benzoquinones; Carboplatin; Carubicin; Cisplatin; Daunorubicin; Doxorubicin; Eflornithine; Epirubicin; Humans; Idarubicin; Mitoxantrone; Naphthacenes; Neoplasms; Organoplatinum Compounds; Ornithine; Ribavirin	1985
Treatment of acute leukemia--advances in chemotherapy, immunotherapy, and bone marrow transplantation. Advances in cancer research, 1983, Volume: 40 Topics: Aclarubicin; Acute Disease; Adolescent; Adult; Age Factors; Aminoacridines; Amsacrine; Anthraquinones; Antibodies, Monoclonal; Azacitidine; Bone Marrow Transplantation; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Humans; Ifosfamide; Immunotherapy; Infant; Interferons; Leukemia; Leukemia, Lymphoid; Liposomes; Middle Aged; Mitoxantrone; Naphthacenes; Prognosis; Teniposide; Transplantation, Homologous; Transplantation, Isogeneic; Vinblastine; Vindesine	1983
Mechanism of action of topoisomerase II-targeted antineoplastic drugs. Advances in pharmacology (San Diego, Calif.), 1994, Volume: 29B Topics: Amsacrine; Animals; Anti-Infective Agents; Antineoplastic Agents; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Doxorubicin; Fluoroquinolones; Humans; Mitoxantrone; Topoisomerase II Inhibitors	1994
DNA topoisomerase II inhibitors. IARC monographs on the evaluation of carcinogenic risks to humans, 2000, Volume: 76 Topics: Amsacrine; Antineoplastic Agents; Carcinogens; Disease Models, Animal; Etoposide; Evidence-Based Medicine; Humans; Intestinal Absorption; Mitoxantrone; Neoplasms; Nucleic Acid Synthesis Inhibitors; Research Design; Risk Factors; Teniposide; Tissue Distribution; Topoisomerase II Inhibitors	2000

Trials

19 trial(s) available for amsacrine and mitoxantrone

Article	Year
Early intensification followed by allo-BMT or auto-BMT or a second intensification in adult ALL: a randomized multicenter study. Leukemia, 1992, Volume: 6 Suppl 2 Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Feasibility Studies; Humans; Italy; Methotrexate; Middle Aged; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Transplantation, Autologous; Transplantation, Homologous; Vincristine	1992
Remission induction and postremission therapy in acute myelogenous leukemia: British MRC Study. Haematology and blood transfusion, 1990, Volume: 33 Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Marrow Transplantation; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dacarbazine; Daunorubicin; Doxorubicin; Drug Combinations; Etoposide; Humans; Leukemia, Myeloid, Acute; Middle Aged; Mitoxantrone; Multicenter Studies as Topic; Nimustine; Prednisone; Randomized Controlled Trials as Topic; Remission Induction; Survival Rate; Thioguanine; United Kingdom; Vincristine	1990
High-dose cytosine arabinoside and amsacrine or mitoxantrone in relapsed and refractory acute myeloid leukaemia: a prospective randomized study. European journal of haematology, 1990, Volume: 45, Issue:3 Topics: Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mitoxantrone; Prospective Studies; Survival Rate	1990
Efficacy of etoposide and mitoxantrone in patients with acute myelogenous leukemia refractory to standard induction therapy and intermediate-dose cytarabine with amsidine. Dutch Hematology-Oncology Working Group for Adults (HOVON). Leukemia, 1994, Volume: 8, Issue:1 Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mitoxantrone; Remission Induction	1994
Allogeneic bone marrow transplantation vs aggressive post-remission chemotherapy for children with acute myeloid leukemia in first complete remission. A prospective study from the French Society of Pediatric Hematology and Immunology (SHIP). Bone marrow transplantation, 1996, Volume: 17, Issue:2 Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Disease-Free Survival; Female; Graft vs Host Disease; Histocompatibility; Humans; Infant; Leukemia, Myeloid; Life Tables; Male; Mitoxantrone; Nuclear Family; Prognosis; Prospective Studies; Remission Induction; Survival Analysis; Transplantation, Homologous; Treatment Outcome	1996
Intensive postremission chemotherapy without maintenance therapy in adults with acute lymphoblastic leukemia. Dutch Hemato-Oncology Research Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:2 Topics: Adolescent; Adult; Amsacrine; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Disease-Free Survival; Drug Administration Schedule; Etoposide; Female; Humans; Male; Middle Aged; Mitoxantrone; Netherlands; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Treatment Outcome	1997
Outcome of a multicenter treatment program including autologous or allogeneic bone marrow transplantation for de novo acute myeloid leukemia. European journal of haematology, 1997, Volume: 58, Issue:4 Topics: Acute Disease; Adolescent; Adult; Age Factors; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Cause of Death; Cytarabine; Disease-Free Survival; Etoposide; Female; Humans; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myelomonocytic, Acute; Male; Middle Aged; Mitoxantrone; Probability; Remission Induction; Survival Rate; Transplantation, Autologous; Transplantation, Homologous	1997
Marked improvements in outcome with chemotherapy alone in paediatric acute myeloid leukemia: results of the United Kingdom Medical Research Council's 10th AML trial. MRC Childhood Leukaemia Working Party. British journal of haematology, 1998, Volume: 101, Issue:1 Topics: Acute Disease; Adolescent; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Child, Preschool; Cytarabine; Daunorubicin; Disease-Free Survival; Etoposide; Female; Humans; Infant; Infant, Newborn; Leukemia, Myeloid; Male; Mitoxantrone; Patient Compliance; Recurrence; Remission Induction; Survival Rate; Thioguanine; Transplantation, Autologous; Transplantation, Homologous; Treatment Outcome	1998
Randomised unicenter trial for comparison of three regimens in de novo adult acute nonlymphoblastic leukaemia. Medical oncology (Northwood, London, England), 1998, Volume: 15, Issue:3 Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Etoposide; Female; Humans; Idarubicin; Leukemia, Myeloid, Acute; Male; Middle Aged; Mitoxantrone; Remission Induction; Survival Analysis	1998
High single dose of mitoxantrone and cytarabine in acute non-lymphocytic leukemia: a pharmacokinetic and clinical study. Therapeutic drug monitoring, 1998, Volume: 20, Issue:6 Topics: Adult; Aged; Amsacrine; Chromatography, High Pressure Liquid; Cytarabine; Drug Administration Schedule; Etoposide; Female; Humans; Injections, Intravenous; Leukemia, Myeloid, Acute; Male; Middle Aged; Mitoxantrone; Neutropenia; Time Factors	1998
Granulocyte colony-stimulating factor after intensive consolidation chemotherapy in acute myeloid leukemia: results of a randomized trial of the Groupe Ouest-Est Leucémies Aigues Myeloblastiques. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:4 Topics: Acute Disease; Adolescent; Adult; Amsacrine; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Etoposide; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Hospitalization; Humans; Length of Stay; Leukemia, Myeloid; Male; Middle Aged; Mitoxantrone; Neutropenia; Recombinant Proteins; Remission Induction; Treatment Outcome	2000
Impact of addition of maintenance therapy to intensive induction and consolidation chemotherapy for childhood acute myeloblastic leukemia: results of a prospective randomized trial, LAME 89/91. Leucámie Aiqüe Myéloïde Enfant. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Jun-15, Volume: 20, Issue:12 Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Child, Preschool; Cytarabine; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Mitoxantrone; Prospective Studies; Recurrence; Treatment Outcome	2002
Maintenance therapy in childhood acute myeloid leukemia. Annals of hematology, 2004, Volume: 83 Suppl 1 Topics: Acute Disease; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Chromosome Aberrations; Cytarabine; Disease-Free Survival; Humans; Leukemia, Myeloid; Mercaptopurine; Mitoxantrone; Prognosis; Survival Analysis; Time Factors	2004
Induction chemotherapy for acute myelogenous leukemia. Current hematology reports, 2005, Volume: 4, Issue:1 Topics: Acute Disease; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Administration Schedule; Etoposide; Humans; Leukemia, Myeloid; Middle Aged; Mitoxantrone; Remission Induction; Survival Analysis; Treatment Outcome	2005
Treatment for myeloid leukaemia of Down syndrome: population-based experience in the UK and results from the Medical Research Council AML 10 and AML 12 trials. British journal of haematology, 2006, Volume: 132, Issue:5 Topics: Adolescent; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Cytogenetic Analysis; Daunorubicin; Down Syndrome; Drug Administration Schedule; Etoposide; Female; Humans; Infant; Leukemia, Myeloid; Leukocyte Count; Male; Mitoxantrone; Thioguanine; Treatment Outcome; United Kingdom	2006
Effect of priming with granulocyte-macrophage colony-stimulating factor in younger adults with newly diagnosed acute myeloid leukemia: a trial by the Acute Leukemia French Association (ALFA) Group. Leukemia, 2007, Volume: 21, Issue:3 Topics: Acute Disease; Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Combined Modality Therapy; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Administration Schedule; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid; Male; Middle Aged; Mitoxantrone; Neoplastic Stem Cells; Premedication; Proportional Hazards Models; Recombinant Proteins; Risk; Salvage Therapy; Stimulation, Chemical; Transplantation, Homologous; Treatment Outcome	2007
Citrulline as a marker for chemotherapy induced mucosal barrier injury in pediatric patients. Pediatric blood & cancer, 2009, Dec-15, Volume: 53, Issue:7 Topics: Acute Disease; Adolescent; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Carbohydrates; Cell Death; Child; Child, Preschool; Citrulline; Cytarabine; Daunorubicin; DNA; Enterocytes; Etoposide; Feces; Female; Humans; Infant; Interleukin-8; Intestinal Absorption; Leukemia, Myeloid; Leukocyte L1 Antigen Complex; Male; Mitoxantrone; Models, Biological; Mucositis; Stomatitis	2009
High-dose cytarabine consolidation with or without additional amsacrine and mitoxantrone in acute myeloid leukemia: results of the prospective randomized AML2003 trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Jun-10, Volume: 31, Issue:17 Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Consolidation Chemotherapy; Cytarabine; Daunorubicin; Female; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mitoxantrone; Prospective Studies; Remission Induction; Survival Analysis; Treatment Outcome; Young Adult	2013
Phase II, multicenter, randomized trial of CPX-351 (cytarabine:daunorubicin) liposome injection versus intensive salvage therapy in adults with first relapse AML. Cancer, 2015, Jan-15, Volume: 121, Issue:2 Topics: Adult; Aged; Aminoglycosides; Amsacrine; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cytarabine; Daunorubicin; Disease-Free Survival; Etoposide; Female; Gemtuzumab; Humans; Injections; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Liposomes; Male; Middle Aged; Mitoxantrone; Recurrence; Remission Induction; Risk Assessment; Salvage Therapy; Treatment Outcome; Vidarabine	2015

Other Studies

72 other study(ies) available for amsacrine and mitoxantrone

Article	Year
Interactions of antitumor drugs with natural DNA: 1H NMR study of binding mode and kinetics. Journal of medicinal chemistry, 1984, Volume: 27, Issue:4 Topics: Antineoplastic Agents; Base Composition; Chemical Phenomena; Chemistry; DNA; Hydrogen Bonding; Intercalating Agents; Kinetics; Magnetic Resonance Spectroscopy; Structure-Activity Relationship	1984
Topoisomerase II-mediated DNA cleavage by adocia- and xestoquinones from the Philippine sponge Xestospongia sp. Journal of medicinal chemistry, 1995, Oct-27, Volume: 38, Issue:22 Topics: Animals; Antineoplastic Agents; Crystallography, X-Ray; DNA; Drug Screening Assays, Antitumor; Humans; Intercalating Agents; Magnetic Resonance Spectroscopy; Molecular Structure; Philippines; Porifera; Quinones; Topoisomerase II Inhibitors; Tumor Cells, Cultured	1995
Inhibition of topoisomerase II catalytic activity by pyridoacridine alkaloids from a Cystodytes sp. ascidian: a mechanism for the apparent intercalator-induced inhibition of topoisomerase II. Journal of medicinal chemistry, 1994, Oct-28, Volume: 37, Issue:22 Topics: Acridines; Alkaloids; Animals; Catalysis; Cell Survival; CHO Cells; Cricetinae; DNA; Humans; Intercalating Agents; Magnetic Resonance Spectroscopy; Pyridones; RNA; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Urochordata	1994
Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridines. Journal of medicinal chemistry, 2003, Mar-13, Volume: 46, Issue:6 Topics: Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Humans; Mice; Naphthyridines; Neoplasm Transplantation; Neoplasms, Experimental; Structure-Activity Relationship; Transplantation, Heterologous; Tumor Cells, Cultured	2003
Bisintercalating threading diacridines: relationships between DNA binding, cytotoxicity, and cell cycle arrest. Journal of medicinal chemistry, 2003, Dec-18, Volume: 46, Issue:26 Topics: Acridines; Antineoplastic Agents; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; DNA; DNA, Superhelical; Electrophoresis, Agar Gel; Flow Cytometry; G2 Phase; Guanine; Humans; Hydrogen Bonding; Intercalating Agents; Kinetics; Mitosis; Structure-Activity Relationship	2003
Validation of model of cytochrome P450 2D6: an in silico tool for predicting metabolism and inhibition. Journal of medicinal chemistry, 2004, Oct-21, Volume: 47, Issue:22 Topics: Binding Sites; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Databases, Factual; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship	2004
Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells. Journal of natural products, 2007, Volume: 70, Issue:12 Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Curcumin; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Humans; K562 Cells; Microscopy, Fluorescence; Molecular Structure; Reactive Oxygen Species; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Design, synthesis, and antitumor activity of new bis-aminomethylnaphthalenes. Bioorganic & medicinal chemistry, 2008, Sep-01, Volume: 16, Issue:17 Topics: Amination; Animals; Antineoplastic Agents; Binding Sites; Cattle; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA; DNA Fragmentation; Drug Design; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Molecular Structure; Naphthalenes; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship; Time Factors	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations. European journal of medicinal chemistry, 2010, Volume: 45, Issue:4 Topics: Antineoplastic Agents; Models, Chemical; Octanols; Quantitative Structure-Activity Relationship; Water	2010
Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation. Bioorganic & medicinal chemistry, 2010, Jun-15, Volume: 18, Issue:12 Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Cell Hypoxia; Cell Line; Colonic Neoplasms; Cricetinae; DNA Damage; DNA Fragmentation; Humans; Phenazines	2010
Structural modifications on the phenazine N,N'-dioxide-scaffold looking for new selective hypoxic cytotoxins. European journal of medicinal chemistry, 2010, Volume: 45, Issue:11 Topics: Animals; Cell Line; Cricetinae; Cytotoxins; Electrochemistry; Hypoxia; Magnetic Resonance Spectroscopy; Molecular Structure; Phenazines; Spectrometry, Mass, Electrospray Ionization	2010
New derivatives of 11-methyl-6-[2-(dimethylamino)ethyl]-6H-indolo[2,3-b]quinoline as cytotoxic DNA topoisomerase II inhibitors. Bioorganic & medicinal chemistry letters, 2012, Oct-01, Volume: 22, Issue:19 Topics: Animals; Antineoplastic Agents; BALB 3T3 Cells; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fibroblasts; HL-60 Cells; Humans; Indoles; Jurkat Cells; Male; MCF-7 Cells; Mice; Molecular Structure; Quinolines; Structure-Activity Relationship; Topoisomerase II Inhibitors	2012
Inhibitors of topoisomerases do not block the passage of human lymphocyte chromosomes through mitosis. Journal of cell science, 1992, Volume: 103 ( Pt 1) Topics: Amsacrine; Camptothecin; Chromosome Aberrations; Chromosomes, Human; Daunorubicin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Ellipticines; Ethidium; Etoposide; Humans; In Vitro Techniques; Lymphocytes; Mitosis; Mitoxantrone; Nalidixic Acid; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors	1992
Multidrug resistance (MDR) gene expression in acute non lymphoblastic leukemia: sequential analysis. Leukemia & lymphoma, 1992, Volume: 8, Issue:4-5 Topics: Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytarabine; Daunorubicin; Female; Follow-Up Studies; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Male; Membrane Glycoproteins; Middle Aged; Mitoxantrone; Neoplasm Proteins; Remission Induction	1992
Antitumor drug cross-resistance in vivo in a cisplatin-resistant murine P388 leukemia. Cancer chemotherapy and pharmacology, 1991, Volume: 27, Issue:6 Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; DNA Topoisomerases, Type II; Drug Resistance; Drug Synergism; Etoposide; Leukemia P388; Mice; Mice, Inbred Strains; Mitoxantrone	1991
[Intensification chemotherapy followed by allogenieic and autologous bone marrow transplantation in acute non-lymphoblastic leukemia in children]. Sangre, 1991, Volume: 36, Issue:1 Topics: Adolescent; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Daunorubicin; Etoposide; Evaluation Studies as Topic; Female; Humans; Infant; Leukemia, Myeloid, Acute; Life Tables; Male; Methotrexate; Mitoxantrone; Remission Induction; Survival Rate; Thioguanine; Transplantation, Autologous; Transplantation, Homologous	1991
[Acute myeloblastic leukemia 5q-. Clinical and cytogenetic remission by means of intensive chemotherapy]. Sangre, 1991, Volume: 36, Issue:3 Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Chromosome Deletion; Chromosomes, Human, Pair 5; Cytarabine; Daunorubicin; Etoposide; Humans; Leukemia, Megakaryoblastic, Acute; Male; Middle Aged; Mitoxantrone; Mosaicism; Remission Induction	1991
Camptothecin, teniposide, or 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells. Cancer research, 1991, Feb-15, Volume: 51, Issue:4 Topics: Amsacrine; Camptothecin; Cell Line; DNA; Doxorubicin; Humans; In Vitro Techniques; Leukemia, Myeloid; Mitoxantrone; S Phase; Teniposide	1991
Involvement of DNA topoisomerase II in the selective resistance of a mammalian cell mutant to DNA minor groove ligands: ligand-induced DNA-protein crosslinking and responses to topoisomerase poisons. Carcinogenesis, 1990, Volume: 11, Issue:4 Topics: Amsacrine; Animals; Anthramycin; Benzimidazoles; Benzodiazepinones; Cell Line; Cell Survival; Distamycins; DNA; DNA Damage; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Intercalating Agents; Ligands; Mice; Mitoxantrone; Mutation; Nuclear Proteins; Pyrroles	1990
Long-term inhibition of DNA synthesis and the persistence of trapped topoisomerase II complexes in determining the toxicity of the antitumor DNA intercalators mAMSA and mitoxantrone. Cancer research, 1990, Sep-15, Volume: 50, Issue:18 Topics: Amsacrine; Cell Cycle; Cell Line; Cell Survival; DNA; DNA Topoisomerases, Type II; Humans; Mitoxantrone; Proteins	1990
Treatment of recurrent acute myelogenous leukaemia at a single centre over a 10-year period. Haematology and blood transfusion, 1990, Volume: 33 Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Combined Modality Therapy; Cytarabine; Doxorubicin; Drug Evaluation; Humans; Interferon Type I; Leukemia, Myeloid, Acute; Middle Aged; Mitoxantrone; Thioguanine; United Kingdom	1990
Treatment of relapsed or refractory acute leukemia: comparison of two different regimens. Haematology and blood transfusion, 1990, Volume: 33 Topics: Acute Disease; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Combined Modality Therapy; Cytarabine; Etoposide; Humans; Leukemia; Mitoxantrone; Neoplasm Recurrence, Local	1990
In vitro DNA strand scission and inhibition of nucleic acid synthesis in L1210 leukemia cells by a new class of DNA complexers, the anthra[1,9-cd]pyrazol-6(2H)-ones (anthrapyrazoles). Biochemical pharmacology, 1985, Oct-01, Volume: 34, Issue:19 Topics: Aminoacridines; Amsacrine; Animals; Anthraquinones; Colony-Forming Units Assay; DNA; Doxorubicin; Kinetics; Leukemia L1210; Mice; Mitoxantrone; Nucleic Acids; Nucleotides; Oxygen Consumption; Pyrazoles; RNA	1985
Isolation of two Chinese hamster ovary cell mutants hypersensitive to topoisomerase II inhibitors and cross-resistant to peroxides. Cancer research, 1989, Aug-15, Volume: 49, Issue:16 Topics: Amsacrine; Animals; Cell Line; Cell Survival; Cricetinae; Dactinomycin; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Etoposide; Female; Mitoxantrone; Mutation; Ovary; Teniposide; Topoisomerase II Inhibitors	1989
Estrogen-induced potentiation of DNA damage and cytotoxicity in human breast cancer cells treated with topoisomerase II-interactive antitumor drugs. Cancer research, 1988, Jan-15, Volume: 48, Issue:2 Topics: Amsacrine; Breast Neoplasms; Cell Survival; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; Doxorubicin; Drug Synergism; Estrogens; Etoposide; Female; Humans; Mitoxantrone; Tumor Cells, Cultured	1988
Calmodulin inhibitor trifluoperazine selectively enhances cytotoxic effects of strong vs weak DNA binding antitumor drugs in doxorubicin-resistant P388 mouse leukemia cells. Biochemical and biophysical research communications, 1985, Sep-16, Volume: 131, Issue:2 Topics: Aminoacridines; Amsacrine; Animals; Anthraquinones; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Line; Dactinomycin; Daunorubicin; DNA; Doxorubicin; Drug Interactions; Drug Resistance; Leukemia P388; Leukemia, Experimental; Menogaril; Mice; Mitoxantrone; Naphthacenes; Nogalamycin; Trifluoperazine	1985
Cross-resistance to intercalating agents in an epipodophyllotoxin-resistant Chinese hamster ovary cell line: evidence for a common intracellular target. Cancer research, 1986, Volume: 46, Issue:4 Pt 2 Topics: Aminoacridines; Amsacrine; Animals; Anthraquinones; Cell Line; Cricetinae; Cricetulus; DNA; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Female; Intercalating Agents; Mitoxantrone; Ovary; Podophyllotoxin	1986
Comparison of results of salvage therapy in adult acute myelogenous leukemia. Acta haematologica, 1987, Volume: 78 Suppl 1 Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Doxorubicin; Drug Evaluation; Humans; Leukemia, Myeloid, Acute; Mitoxantrone; Prednisone; Prognosis; Prospective Studies; Recurrence; Regression Analysis; Retrospective Studies; Vincristine	1987
Radionuclide angiographic monitoring in patients treated with potentially cardiotoxic cytostatic drugs. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1988, Sep-03, Volume: 74, Issue:5 Topics: Amsacrine; Antibiotics, Antineoplastic; Daunorubicin; Doxorubicin; Electrocardiography; Epirubicin; Female; Heart; Humans; Idarubicin; Male; Mitoxantrone; Prospective Studies; Radionuclide Angiography; Stroke Volume	1988
Sequential pilot studies of intensive postremission chemotherapy for acute nonlymphocytic leukemia. Annals of the New York Academy of Sciences, 1987, Volume: 511 Topics: Acute Disease; Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; Combined Modality Therapy; Cytarabine; Daunorubicin; Etoposide; Female; Humans; Leukemia; Male; Middle Aged; Mitoxantrone; Pilot Projects; Thioguanine	1987
Chemotherapy in metastatic melanoma: phase II studies of amsacrine, mitoxantrone and bisantrene. European journal of cancer & clinical oncology, 1986, Volume: 22, Issue:1 Topics: Aminoacridines; Amsacrine; Anthracenes; Anthraquinones; Antineoplastic Agents; Drug Evaluation; Female; Humans; Male; Melanoma; Middle Aged; Mitoxantrone; Phlebitis; Skin Neoplasms	1986
[A new drug and current strategy in the treatment of acute non-lymphocytic leukemia in adults]. Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:5 Topics: Acute Disease; Adult; Aminoacridines; Amsacrine; Anthraquinones; Antineoplastic Agents; Cytarabine; Drug Administration Schedule; Etoposide; Humans; Leukemia; Mitoxantrone	1986
Effects of amsacrine and other DNA-intercalating drugs on nuclear and nucleolar structure in cultured V79 Chinese hamster cells and PtK2 rat kangaroo cells. Cancer research, 1985, Volume: 45, Issue:2 Topics: Aminacrine; Aminoacridines; Amsacrine; Animals; Anthraquinones; Cell Nucleolus; Cell Nucleus; Cell Survival; Cell Transformation, Neoplastic; Cricetinae; Cricetulus; Dactinomycin; Dipodomys; Doxorubicin; Fibroblasts; Intercalating Agents; Kidney; Microscopy, Electron; Mitoxantrone	1985
Comparative cardiac oxygen radical metabolism by anthracycline antibiotics, mitoxantrone, bisantrene, 4'-(9-acridinylamino)-methanesulfon-m-anisidide, and neocarzinostatin. Biochemical pharmacology, 1983, Oct-01, Volume: 32, Issue:19 Topics: Aminoacridines; Amsacrine; Animals; Anthracenes; Anthraquinones; Antibiotics, Antineoplastic; Antineoplastic Agents; Male; Mitochondria, Heart; Mitoxantrone; Myocardium; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum; Submitochondrial Particles; Superoxides; Zinostatin	1983
Effect of temperature on the cytotoxicity of vindesine, amsacrine, and mitoxantrone. Cancer treatment reports, 1983, Volume: 67, Issue:11 Topics: Aminoacridines; Amsacrine; Animals; Anthraquinones; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Hot Temperature; Mitoxantrone; Vinblastine; Vindesine	1983
Absence of delayed lethality in mice treated with aclacinomycin A. Cancer chemotherapy and pharmacology, 1981, Volume: 6, Issue:2 Topics: Aclarubicin; Aminoacridines; Amsacrine; Animals; Anthracenes; Antibiotics, Antineoplastic; Doxorubicin; Female; Male; Mice; Mice, Inbred Strains; Mitoxantrone; Naphthacenes	1981
Current status of clinical trials of m-AMSA, dihydroxyanthracenedione, and deoxycoformycin. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1982, Volume: 80 Topics: Adenosine Deaminase Inhibitors; Aminoacridines; Amsacrine; Anthracenes; Antineoplastic Agents; Coformycin; Drug Administration Schedule; Drug Evaluation; Female; Humans; Leukemia; Mitoxantrone; Neoplasms; Nucleoside Deaminases; Pentostatin; Ribonucleosides	1982
Impact of reinduction regimens for relapsed and refractory acute lymphoblastic leukemia in adults. American journal of hematology, 1994, Volume: 45, Issue:4 Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Aspartate-Ammonia Ligase; Clinical Trials as Topic; Cytarabine; Dose-Response Relationship, Drug; Humans; Idarubicin; Incidence; Methotrexate; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Salvage Therapy	1994
Interactions between cladribine (2-chlorodeoxyadenosine) and standard antileukemic drugs in primary cultures of human tumor cells from patients with acute myelocytic leukemia. Leukemia, 1994, Volume: 8, Issue:10 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amsacrine; Antineoplastic Agents; Cladribine; Cytarabine; Daunorubicin; Drug Interactions; Drug Screening Assays, Antitumor; Drug Synergism; Etoposide; Female; Fluoresceins; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mitoxantrone; Tumor Cells, Cultured	1994
Topoisomerase II alpha co-amplification with erbB2 in human primary breast cancer and breast cancer cell lines: relationship to m-AMSA and mitoxantrone sensitivity. Oncogene, 1993, Volume: 8, Issue:4 Topics: Adult; Aged; Amsacrine; Breast Neoplasms; DNA Topoisomerases, Type II; DNA, Neoplasm; ErbB Receptors; Gene Amplification; Humans; In Vitro Techniques; Lymphatic Metastasis; Middle Aged; Mitoxantrone; Oncogenes; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptors, Estrogen; Tumor Cells, Cultured	1993
(R,R)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]- bis[5-nitro-1H-benz[de]isoquinoline-1,3-(2H)-dione] dimethanesulfonate (DMP 840), a novel bis-naphthalimide with potent nonselective tumoricidal activity in vitro. Cancer research, 1994, Apr-15, Volume: 54, Issue:8 Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Division; Clinical Trials, Phase I as Topic; Colonic Neoplasms; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Isoquinolines; KB Cells; Kinetics; Leucine; Leukemia L1210; Leukemia P388; Mammary Neoplasms, Experimental; Melanoma; Melanoma, Experimental; Mesylates; Mice; Mitoxantrone; Thymidine; Transplantation, Heterologous; Tumor Cells, Cultured; Uridine	1994
[The current chemotherapy of acute myeloid leukemias in adults]. Terapevticheskii arkhiv, 1993, Volume: 65, Issue:7 Topics: Aclarubicin; Acute Disease; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Etoposide; Humans; Idarubicin; Leukemia, Myeloid; Mitoxantrone; Prognosis; Remission Induction; Time Factors	1993
Treatment of relapsing and refractory adult acute myeloid leukemia according to in vitro clonogenic leukemic cell drug sensitivity. Leukemia & lymphoma, 1993, Volume: 10, Issue:1-2 Topics: Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Etoposide; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Middle Aged; Mitoxantrone; Pilot Projects; Prospective Studies; Recurrence; Salvage Therapy; Tumor Stem Cell Assay	1993
Similar sequence specificity of mitoxantrone and VM-26 stimulation of in vitro DNA cleavage by mammalian DNA topoisomerase II. Biochemistry, 1993, Mar-30, Volume: 32, Issue:12 Topics: Amsacrine; Animals; Base Sequence; Binding Sites; DNA; DNA Topoisomerases, Type II; DNA, Viral; Electrophoresis, Agar Gel; Idarubicin; Leukemia P388; Mice; Mitoxantrone; Molecular Sequence Data; Mutagenesis; Oligodeoxyribonucleotides; Simian virus 40; Substrate Specificity; Teniposide; Tumor Cells, Cultured	1993
Pneumocystis carinii pneumonia in adults with acute leukaemia: is there a need for primary chemoprophylaxis? European journal of haematology, 1996, Volume: 56, Issue:3 Topics: Aclarubicin; Acute Disease; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cohort Studies; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Etoposide; Female; Finland; Humans; Immunocompromised Host; Incidence; Leukemia; Male; Mercaptopurine; Methotrexate; Middle Aged; Mitoxantrone; Pneumonia, Pneumocystis; Prednisone; Premedication; Retrospective Studies; Thioguanine; Trimethoprim, Sulfamethoxazole Drug Combination; Vincristine	1996
Intensive induction and consolidation chemotherapy in a young woman with acute myeloid leukemia and severe chronic renal failure. Annals of hematology, 1996, Volume: 72, Issue:5 Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Contraindications; Cytarabine; Daunorubicin; Etoposide; Female; Humans; Kidney Failure, Chronic; Leukemia, Myeloid, Acute; Mitoxantrone	1996
The distribution of topoisomerase II on mammalian chromosomes. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 1996, Volume: 4, Issue:1 Topics: Amsacrine; Animals; Cells, Cultured; CHO Cells; Cricetinae; DNA Topoisomerases, Type II; Etoposide; Fibroblasts; Fluorescent Antibody Technique; Humans; L Cells; Lymphocytes; Mice; Mitosis; Mitoxantrone; Muridae; Rats; Topoisomerase II Inhibitors	1996
In vitro resistance to cytosine arabinoside, not to daunorubicin, is associated with the risk of relapse in de novo acute myeloid leukaemia. British journal of haematology, 1996, Volume: 93, Issue:4 Topics: Acute Disease; Adolescent; Adult; Aged; Amsacrine; Antigens, CD34; Antineoplastic Agents; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Etoposide; Female; Humans; Leukemia, Myeloid; Male; Middle Aged; Mitoxantrone; Recurrence; Risk Factors; Treatment Outcome	1996
A simple ligation assay to detect effects of drugs on the curvature/flexibility of DNA. FEBS letters, 1996, Nov-04, Volume: 396, Issue:2-3 Topics: Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Daunorubicin; DNA; DNA Ligases; DNA, Circular; Intercalating Agents; Mitoxantrone; Nucleic Acid Conformation; Plasmids	1996
Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4. British journal of cancer, 1996, Volume: 74, Issue:12 Topics: Amsacrine; Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Carcinoma, Small Cell; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance, Multiple; Humans; In Situ Hybridization, Fluorescence; Isoenzymes; Lung Neoplasms; Mitoxantrone; Multidrug Resistance-Associated Proteins; RNA, Messenger; RNA, Neoplasm; Teniposide; Tumor Cells, Cultured	1996
Cytotoxic efficacy with combinations of topoisomerase I and topoisomerase II inhibitors in sensitive and multidrug-resistant L1210 mouse leukemia cells. Annals of the New York Academy of Sciences, 1996, Dec-13, Volume: 803 Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Resistance, Multiple; Drug Synergism; Enzyme Inhibitors; Etoposide; Leukemia L1210; Mice; Mitoxantrone; Topoisomerase I Inhibitors; Topotecan	1996
Pharmacology of cytarabine given as a continuous infusion followed by mitoxantrone with and without amsacrine/etoposide as reinduction chemotherapy for relapsed or refractory pediatric acute myeloid leukemia. Medical and pediatric oncology, 1998, Volume: 31, Issue:6 Topics: Acute Disease; Adolescent; Amsacrine; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cytarabine; Etoposide; Female; Humans; Infant; Infusions, Intravenous; Leukemia, Myeloid; Male; Mitoxantrone; Recurrence; Remission Induction	1998
Prophylactic platelet transfusion threshold during therapy for adult acute myeloid leukemia: 10,000/microL versus 20,000/microL. Haematologica, 1998, Volume: 83, Issue:11 Topics: Acute Disease; Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Etoposide; Hemorrhage; Humans; Idarubicin; Leukemia, Myeloid; Middle Aged; Mitoxantrone; Pancytopenia; Platelet Count; Platelet Transfusion; Retrospective Studies; Spain; Thrombocytopenia	1998
Induction of diplochromosomes in mammalian cells by inhibitors of topoisomerase II. Chromosoma, 1998, Volume: 107, Issue:6-7 Topics: Amsacrine; Animals; CHO Cells; Chromatids; Chromosome Aberrations; Chromosome Segregation; Cricetinae; Demecolcine; DNA Topoisomerases, Type II; Enzyme Inhibitors; Etoposide; Interphase; Metaphase; Mitoxantrone; Nucleic Acid Synthesis Inhibitors; Topoisomerase II Inhibitors	1998
Murine transgenic cells lacking DNA topoisomerase IIbeta are resistant to acridines and mitoxantrone: analysis of cytotoxicity and cleavable complex formation. Molecular pharmacology, 1999, Volume: 56, Issue:6 Topics: Acridines; Amsacrine; Animals; Antigens, Neoplasm; Antineoplastic Agents; Cell Survival; Cells, Cultured; DNA Topoisomerases, Type II; DNA-Binding Proteins; Etoposide; Isoenzymes; Mice; Mice, Transgenic; Mitoxantrone; Topoisomerase II Inhibitors	1999
Effects of protein binding on the in vitro activity of antitumour acridine derivatives and related anticancer drugs. Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:5 Topics: Amsacrine; Animals; Antineoplastic Agents; Blood Proteins; Carcinoma, Lewis Lung; Cattle; Doxorubicin; Etoposide; Humans; Mice; Mitoxantrone; Orosomucoid; Protein Binding; Serum Albumin; Vincristine	2000
Atp-bound topoisomerase ii as a target for antitumor drugs. The Journal of biological chemistry, 2001, May-11, Volume: 276, Issue:19 Topics: Adenosine Triphosphate; Amino Acid Substitution; Amsacrine; Animals; Antineoplastic Agents; Cattle; DNA Topoisomerases, Type II; Doxorubicin; Etoposide; Kinetics; Mitoxantrone; Mutagenesis, Site-Directed; Recombinant Proteins; Teniposide; Thymus Gland	2001
Pretreatment leukaemia cell drug resistance is correlated to clinical outcome in acute myeloid leukaemia. European journal of haematology, 2001, Volume: 66, Issue:3 Topics: Aclarubicin; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Etoposide; Female; Humans; Idarubicin; Leukemia, Myeloid; Male; Middle Aged; Mitoxantrone; Neoplastic Stem Cells; Prognosis; Remission Induction; Survival Analysis; Thioguanine; Treatment Outcome; Tumor Cells, Cultured	2001
Altered topoisomerase IIalpha and multidrug resistance-associated protein levels during drug selection: adaptations to increasing drug pressure. Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:9 Topics: Amsacrine; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carcinoma; Clone Cells; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Induction; Enzyme Inhibitors; Etoposide; Female; Humans; Mitoxantrone; Neoplasm Proteins; Nucleic Acid Synthesis Inhibitors; RNA, Messenger; RNA, Neoplasm; Selection, Genetic; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Stem Cell Assay; Vincristine	2001
Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome. Blood, 2002, Jan-01, Volume: 99, Issue:1 Topics: Amsacrine; Anthracyclines; Antineoplastic Agents; Busulfan; Cell Survival; Child; Child, Preschool; Cytarabine; Down Syndrome; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Etoposide; Female; Humans; Infant; Leukemia, Myeloid, Acute; Male; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Thioguanine; Vincristine	2002
FAB M4 and high CD14 surface expression is associated with high cellular resistance to Ara-C and daunorubicin: implications for clinical outcome in acute myeloid leukaemia. European journal of haematology, 2001, Volume: 67, Issue:4 Topics: Aclarubicin; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Amsacrine; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Cohort Studies; Cytarabine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Female; Humans; Idarubicin; Leukemia, Myeloid; Leukemia, Myelomonocytic, Acute; Lipopolysaccharide Receptors; Male; Middle Aged; Mitoxantrone; Multivariate Analysis; Neoplastic Stem Cells; Thioguanine; Treatment Outcome	2001
A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents. Biochemistry, 2002, Jun-25, Volume: 41, Issue:25 Topics: Amino Acid Sequence; Amino Acid Substitution; Amsacrine; Antineoplastic Agents; Bacteriophage T4; Binding Sites; DNA Damage; DNA Topoisomerases, Type II; DNA, Superhelical; Ellipticines; Enzyme Inhibitors; Filtration; Glycine; Mitoxantrone; Molecular Sequence Data; Oxolinic Acid; Podophyllotoxin; Point Mutation; Topoisomerase II Inhibitors; Valine	2002
Favorable outcome with STI571 (imatinib mesylate) and allogeneic stem cell transplantation in a case of Ph+ chemorefractory acute lymphocytic leukaemia. Bone marrow transplantation, 2002, Volume: 30, Issue:12 Topics: Adult; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Betamethasone; Biomarkers, Tumor; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Female; Fusion Proteins, bcr-abl; Graft vs Host Disease; Humans; Imatinib Mesylate; Immunosuppressive Agents; Mitoxantrone; Neoplasm, Residual; Peripheral Blood Stem Cell Transplantation; Piperazines; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Remission Induction; Reverse Transcriptase Polymerase Chain Reaction; Transplantation, Homologous; Vincristine	2002
Differences in the longevity of topo IIalpha and topo IIbeta drug-stabilized cleavable complexes and the relationship to drug sensitivity. Cancer chemotherapy and pharmacology, 2004, Volume: 53, Issue:2 Topics: Amsacrine; Animals; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Neoplasm; Etoposide; Fibroblasts; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique; Fluorescent Dyes; Half-Life; Isoenzymes; Kinetics; Mice; Mitoxantrone	2004
Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells. Leukemia research, 2006, Volume: 30, Issue:7 Topics: Amsacrine; Antineoplastic Agents; Digitoxin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Etoposide; Humans; Idarubicin; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitoxantrone; Structure-Activity Relationship; Topoisomerase II Inhibitors	2006
Improved outcome in childhood acute myeloid leukemia in Singapore with the MRC AML 10 protocol. Pediatric blood & cancer, 2007, Volume: 48, Issue:3 Topics: Acute Disease; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cytarabine; Daunorubicin; Developing Countries; Disease-Free Survival; Drug Evaluation; Etoposide; Female; Gastrointestinal Diseases; Heart Diseases; Hematologic Diseases; Humans; Infant; Infections; Kaplan-Meier Estimate; Leukemia, Myeloid; Male; Mercaptopurine; Methotrexate; Mitoxantrone; Prednisone; Remission Induction; Retrospective Studies; Singapore; Survival Analysis; Thioguanine; Treatment Outcome; Vincristine	2007
Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugs. Cancer research, 2007, Jun-15, Volume: 67, Issue:12 Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Line, Tumor; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Ellipticines; Etoposide; Humans; Immunoblotting; Mice; Microscopy, Confocal; Mitoxantrone; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Proto-Oncogene Proteins c-mdm2; Reverse Transcriptase Polymerase Chain Reaction	2007
On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs. Nucleic acids research, 2013, Volume: 41, Issue:22 Topics: Amsacrine; Antigens, Neoplasm; Antineoplastic Agents; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Design; Guidelines as Topic; Humans; Mitoxantrone; Models, Molecular; Poly-ADP-Ribose Binding Proteins; Structure-Activity Relationship; Topoisomerase II Inhibitors	2013
Novel ametantrone-amsacrine related hybrids as topoisomerase IIβ poisons and cytotoxic agents. Archiv der Pharmazie, 2014, Volume: 347, Issue:10 Topics: Amsacrine; Cell Proliferation; Cell Survival; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Design; HL-60 Cells; Humans; Inhibitory Concentration 50; MCF-7 Cells; Mitoxantrone; Molecular Structure; Neoplasms; Structure-Activity Relationship; Topoisomerase II Inhibitors	2014
Studies on Non-synonymous Polymorphisms Altering Human DNA Topoisomerase II-Alpha Interaction with Amsacrine and Mitoxantrone: An Current cancer drug targets, 2017, Volume: 17, Issue:7 Topics: Amsacrine; Antineoplastic Agents; Computer Simulation; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Humans; Mitoxantrone; Molecular Docking Simulation; Poly-ADP-Ribose Binding Proteins; Polymorphism, Single Nucleotide; Protein Conformation; Topoisomerase II Inhibitors	2017