amsacrine and hydroxyurea

amsacrine has been researched along with hydroxyurea in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19908 (57.14)18.7374
1990's2 (14.29)18.2507
2000's2 (14.29)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Lihou, MG; Smith, PJ; Tomlinson, FH1
Ferguson, LR1
Estey, E; Silberman, L; Zwelling, LA1
Andersson, HC; Kihlman, BA1
Covey, JM; Holm, C; Kerrigan, D; Pommier, Y1
Cordel, K; Holm, C; Vaughan, WP1
Fernandes, DJ; Neff, TA; Paff, MT; Smith-Nanni, C1
Haanen, C; Marie, JP; Marquet, J; Zittoun, J; Zittoun, R1
Jehn, U; Löwenberg, B; Zittoun, R1
Kerrigan, D; Minford, J; Nichols, M; Shackney, S; Zwelling, LA1
Kreuzer, KN; Long, DT1

Reviews

1 review(s) available for amsacrine and hydroxyurea

ArticleYear
Intercalator-induced, topoisomerase II-mediated DNA cleavage and its modification by antineoplastic antimetabolites.
    International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:7

    Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Azacitidine; Cell Survival; Cytarabine; DNA; DNA Topoisomerases, Type II; Drug Synergism; Humans; Hydroxyurea; In Vitro Techniques; Intercalating Agents; Mice

1986

Trials

1 trial(s) available for amsacrine and hydroxyurea

ArticleYear
[AML-6 and AML-7 studies on the treatment of acute myelocytic leukemia. Cyclic alternating chemotherapy during remission, and induction of remission and survival of elderly patients].
    Onkologie, 1985, Volume: 8, Issue:3

    Topics: Adult; Age Factors; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azaguanine; Cytarabine; Daunorubicin; Drug Administration Schedule; Humans; Hydroxyurea; Leukemia, Myeloid, Acute; Middle Aged; Vincristine

1985

Other Studies

12 other study(ies) available for amsacrine and hydroxyurea

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of in vitro activity of epipodophyllotoxins with other chemotherapeutic agents in human medulloblastomas.
    British journal of cancer, 1991, Volume: 64, Issue:6

    Topics: Alkylating Agents; Amsacrine; Cell Division; Cell Survival; Cross-Linking Reagents; Cytarabine; DNA Damage; DNA Topoisomerases, Type II; Drug Resistance; Etoposide; Humans; Hydroxyurea; In Vitro Techniques; Karyotyping; Medulloblastoma; Teniposide; Tumor Cells, Cultured; Vincristine

1991
Mutagenic and recombinogenic consequences of DNA-repair inhibition during treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea in Saccharomyces cerevisiae.
    Mutation research, 1990, Volume: 241, Issue:4

    Topics: Amsacrine; Caffeine; Carmustine; Crossing Over, Genetic; DNA Repair; Hydroxyurea; Mutagenicity Tests; Mutation; Saccharomyces cerevisiae

1990
The production of chromosomal alterations in human lymphocytes by drugs known to interfere with the activity of DNA topoisomerase II. I. m-AMSA.
    Carcinogenesis, 1989, Volume: 10, Issue:1

    Topics: Amsacrine; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Chromosomes; Culture Media; Cytarabine; DNA Repair; Humans; Hydroxyurea; In Vitro Techniques; Lymphocytes; Sister Chromatid Exchange; Topoisomerase II Inhibitors; X-Rays

1989
Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells.
    Cancer research, 1989, Nov-15, Volume: 49, Issue:22

    Topics: Amsacrine; Animals; Aphidicolin; Camptothecin; Cell Line; Cell Survival; Cricetinae; Cricetulus; Diterpenes; DNA Replication; Etoposide; Hydroxyurea; Kinetics; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1989
Hydroxyurea potentiation of the antineoplastic activity of cyclophosphamide and 4'-(9-acridinylamino)methanesulfon-M-anisidide (AMSA) in the brown Norway rat myelocytic leukemia model.
    Cancer chemotherapy and pharmacology, 1989, Volume: 23, Issue:1

    Topics: Amsacrine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Hydroxyurea; Leukemia, Myeloid; Rats; Rats, Inbred BN

1989
Effects of antileukemia agents on nuclear matrix-bound DNA replication in CCRF-CEM leukemia cells.
    Cancer research, 1988, Apr-01, Volume: 48, Issue:7

    Topics: Amsacrine; Antineoplastic Agents; Cell Nucleus; Chromatin; Cytarabine; DNA Replication; Hydroxyurea; Microscopy, Electron; Nuclear Proteins; Teniposide; Tumor Cells, Cultured

1988
Modulation of cytosine arabinoside (ara-C) and high-dose ara-C in acute leukemia.
    Seminars in oncology, 1985, Volume: 12, Issue:2 Suppl 3

    Topics: Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Resistance; Humans; Hydroxyurea; Interphase; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Thymidine

1985
Enhancement of the DNA breakage and cytotoxic effects of intercalating agents by treatment with sublethal doses of 1-beta-D-arabinofuranosylcytosine or hydroxyurea in L1210 cells.
    Cancer research, 1984, Volume: 44, Issue:12 Pt 1

    Topics: Aminoacridines; Amsacrine; Animals; Bleomycin; Cell Survival; Cytarabine; Daunorubicin; DNA, Neoplasm; Doxorubicin; Drug Synergism; Hydroxyurea; Intercalating Agents; Leukemia L1210; Mice

1984
Regression supports two mechanisms of fork processing in phage T4.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, May-13, Volume: 105, Issue:19

    Topics: Amsacrine; Bacteriophage T4; DNA Replication; Endodeoxyribonucleases; Escherichia coli; Hydroxyurea; Models, Biological; Mutation; Replication Origin; Viral Proteins

2008