Compounds > amsacrine

amsacrine and camptothecin

amsacrine has been researched along with camptothecin in 90 studies

Research

Studies (90)

TimeframeStudies, this research(%)All Research%
pre-19908 (8.89)18.7374
1990's50 (55.56)18.2507
2000's10 (11.11)29.6817
2010's22 (24.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baguley, BC; Deady, LW; Denny, WA; Finlay, GJ; Kaye, AJ1
Baguley, BC; Bu, X; Deady, LW; Denny, WA; Finlay, GJ1
Baguley, BC; Deady, LW; Denny, WA; Rodemann, T; Zhuang, L1
Bu, X; Eleftheriou, A; Hayek, C; Parmar, A; Stewart, BW; Wakelin, LP1
Austin, CA; Curtis, H; Gilroy, KL; Jobson, A; López-Lázaro, M; Padget, K; Willmore, E1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, YL; Chen, YW; Liang, CC; Lu, PJ; Tseng, CH; Tzeng, CC; Yang, CN; Yao, YC1
Andaloussi, M; Bussière, A; Canitrot, D; Chavignon, O; Chezal, JM; Debiton, E; Galmier, MJ; Gaudreault, RC; Jacquemet, A; Lacroix, J; Masurier, N; Moreau, E; Ollivier, A; Tétégan, D; Teulade, JC1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chang, IH; Jun, KY; Kwon, Y; Lee, E; Lee, ES; Na, Y; Park, SE1
Abdel-Aziz, M; Abuo-Rahma, Gel-D; Kwon, Y; Park, SE; Sayed, MA1
Baumann, M; Baxendale, IR; Broggini, G; Bucci, R; Calogero, F; Christodoulou, MS; Dalla Via, L; Dapiaggi, F; García-Argáez, AN; Gazzola, S; Lahtela-Kakkonen, M; Liekens, S; Martinet, N; Nonell-Canals, A; Passarella, D; Pieraccini, S; Santamaría-Navarro, E; Silvani, A; Sironi, M1
Bist, G; Jun, KY; Kadayat, TM; Kwon, Y; Lee, ES; Park, S; Shrestha, A; Thapa Magar, TB1
Islam, MS; Kadi, AA; Kwon, Y; Park, S; Rahman, AF; Song, C1
Bist, G; Kadayat, TM; Kwon, Y; Lee, ES; Lee, HJ; Park, S; Shrestha, A; Thapa Magar, TB1
Bist, G; Kwon, Y; Lee, ES; Park, S; Shrestha, A; Song, C; Thapa Magar, TB1
Chen, S; Chen, Y; Gao, C; Jiang, Y; Li, D; Song, L; Tan, C; Yuan, Z; Zhang, C1
Chen, C; Chen, J; Chen, S; Dai, Q; Gao, C; Jiang, Y; Yuan, Z1
Cho, WJ; Han, J; Jin, Y; Khadka, DB; Kwon, Y; Park, S1
Das, BB; Das, SK; Ghosh, A; Halder, N; Paul Chowdhuri, S; Rath, H; Rehman, I; Sahoo, KC; Sengupta, S1
Chen, HX; Dong, CZ; Du, ZY; Huang, ZS; Jiang, H; Li, PH; Li, YL; Tang, YD; Zhang, LY; Zhang, WJ; Zhao, MC; Zhou, W1
Chen, J; Gao, C; Jiang, Y; Li, D; Li, W; Liu, F; Yin, J; Yuan, Z; Zhang, Y1
Jang, HJ; Katila, P; Kwon, Y; Lee, ES; Park, S; Shrestha, A; Shrestha, R1
Barresi, E; Da Settimo, F; Dalla Via, L; García-Argáez, AN; Hyeraci, M; La Pietra, V; Marinelli, L; Marini, AM; Milite, C; Novellino, E; Robello, M; Salerno, S; Simorini, F; Taliani, S1
Bhattacharya, D; Das, BB; Das, SK; Ghosh, A; Kundu, B; Mukherjee, A; Pal, S; Paul Chowdhuri, S; Sarkar, D; Talukdar, A1
Hwang, SY; Jeon, YH; Jeong, TC; Jo, H; Kadayat, TM; Katila, P; Kim, KS; Kim, SK; Koh, WS; Kwon, Y; Lee, ES; Nepal, MR; Noh, K; Park, S; Shrestha, A; Shrestha, R1
Dou, Z; He, S; Jin, H; Wang, N; Xiong, Z; Yan, X; Zhang, B1
Nishioka, WK; Welsh, RM1
Kondo, K; Kume, T; Oishi, M; Shiraishi, T; Tsuneizumi, K; Watanabe, T1
Sumner, AT1
Epe, B; Hoehn, H; Poot, M1
Holmström, M; Winters, V1
Fujii, N; Kawada, S; Nakano, H; Yamashita, Y1
Boyer, JC; Estabrooks, LL; Kaufmann, WK; Wilson, SJ1
Bae, YS; Chiba, M; Ikeda, H; Ohira, M1
Darzynkiewicz, Z; Del Bino, G; Skierski, JS1
Beck, WT; Danks, MK1
Adachi, K; Andrea, JE; Morgan, AR1
Adams, DJ; Bair, KW; Elstein, KH; Zucker, RM1
Beardmore, C; D'Arpa, P; Liu, LF1
Kaufmann, SH1
Darzynkiewicz, Z; Del Bino, G1
Hanna, N; Mattern, MR; Mirabelli, CK; Utsugi, T1
Andersson, BS; Ling, YH; Nelson, JA1
Allen, JW; Backer, LC; Campbell, JA; DeMarini, DM; Doerr, CL; Harrington-Brock, K; Howard, DR; Kligerman, AD; Moore, MM1
Davies, SM; Harris, AL; Hickson, ID1
Bartus, JO; Drake, FH; Hertzberg, RP; Hofmann, GA; Johnson, RK; Mattern, MR; Mirabelli, CK; Mong, SM1
Covey, JM; Holm, C; Kerrigan, D; Pommier, Y1
Eng, WK; Johnson, RK; Mattern, MR; McCabe, FL; Tan, KB1
Covey, JM; Kao-Shan, CS; Kerrigan, D; Pommier, Y; Whang-Peng, J1
Jacobson-Kram, D; Lim, M; Liu, LF; Williams, JR1
Mui, SC; Strauss, PR; Todt, JC; Zhang, LH1
Snapka, RM1
Austin, MJ; Bunch, RT; Povirk, LF1
Heimpel, S; Hiller, KH; Hoehn, H; Poot, M1
Cortés, F; Palitti, F; Piñero, J1
Cortés, F; Ortiz, T; Piñero, J1
Benchokroun, Y; Larsen, AK; Lelièvre, S1
Sitailo, LA; Zagariya, AM1
Gupta, M; Jenkins, J; Poddevin, B; Pommier, Y1
Ellis, AL; Nowak, B; Plunkett, W; Zwelling, LA1
Cortés, F; Piñero, J1
Prost, S; Riou, G1
Inaba, M; Kawada, S; Mitsuhashi, J; Nakano, H1
Hsiung, Y; Liu, YX; Nitiss, JL1
Bertrand, R; Kohn, KW; Pommier, Y; Solary, E1
Darzynkiewicz, Z; Gorczyca, W; Melamed, MR1
Auclair, C; Carteau, S; Goulaouic, H; Mouscadet, JF; Subra, F1
Dilworth, A; Myers, CE; Sinha, BK; Yamazaki, H1
Abitbol, M; Grondard, L; Lavelle, F; Petitgenet, O; Riou, JF1
Astaldi Ricotti, GC; Evans, HH; Lanza, A; Pedrini, AM; Ricanati, M; Stefanini, M; Tornaletti, S1
Castora, FJ; Lin, JH1
Creus, A; Marcos, R; Ribas, G; Xamena, N1
Cortés, F; López Baena, M; Ortiz, T; Piñero, J1
Nitiss, JL; Wang, JC1
Ganapathi, R; Grabowski, D1
Falaschi, A; Ochem, A; Phan, TN; Tuteja, N; Tuteja, R1
Phan, TN; Tuteja, N1
Creus, A; Marcos, R; Torres, C1
Carabillò, M; Giuliano, M; Lauricella, M; Tesoriere, G; Vassallo, E; Vento, R1
Emanuele, S; Giuliano, M; Lauricella, M; Tesoriere, G; Vento, R1
Cortés, F; López-Baena, M; Mateos, S; Piñero, J1
Carabillò, M; Emanuele, S; Giuliano, M; Lauricella, M; Tesoriere, G; Vento, R1
Baguley, BC; Bridewell, DJ; Finlay, GJ1
Dennis, T; Edwards, TK; Gartenberg, MR; Gerigk, C; Oliveros, E; Rubin, EH; Saleem, A; Shaman, JA1
Freudenreich, CH; Kreuzer, KN; Pommier, Y1
Darzynkiewicz, Z; Juan, G; Traganos, F1
Davey, M; Davey, R; Locke, V1
Bradford, A; Brockhurst, K; Lynch, AM; Mahabir, AG; Rees, RW; van Benthem, J; van Steeg, H1
Bailey, L; de Vries, A; Hendriksen, CF; Korsten, H; Lynch, AM; Mahabir, AG; van Benthem, J; van Steeg, H1

Reviews

1 review(s) available for amsacrine and camptothecin

ArticleYear
Mechanisms of resistance to drugs that inhibit DNA topoisomerases.
    Seminars in cancer biology, 1991, Volume: 2, Issue:4

    Topics: Amsacrine; Animals; Antineoplastic Agents; Camptothecin; Cricetinae; Daunorubicin; DNA Replication; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Etoposide; Humans; Mice; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1991

Other Studies

89 other study(ies) available for amsacrine and camptothecin

ArticleYear
Synthesis and antitumor properties of N-[2-(dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: a new class of putative topoisomerase inhibitors.
    Journal of medicinal chemistry, 1997, Jun-20, Volume: 40, Issue:13

    Topics: Acridines; Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Mice; Mice, Inbred C57BL; Models, Chemical; Phenazines; Quinolines; Quinoxalines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1997
Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives.
    Journal of medicinal chemistry, 2001, Jun-07, Volume: 44, Issue:12

    Topics: Animals; Antineoplastic Agents; Cell Survival; Colonic Neoplasms; Doxorubicin; Drug Design; Drug Resistance, Neoplasm; Humans; Indicators and Reagents; Isoquinolines; Jurkat Cells; Leukemia P388; Lung Neoplasms; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Conformation; Molecular Structure; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured

2001
Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridines.
    Journal of medicinal chemistry, 2003, Mar-13, Volume: 46, Issue:6

    Topics: Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Humans; Mice; Naphthyridines; Neoplasm Transplantation; Neoplasms, Experimental; Structure-Activity Relationship; Transplantation, Heterologous; Tumor Cells, Cultured

2003
Bisintercalating threading diacridines: relationships between DNA binding, cytotoxicity, and cell cycle arrest.
    Journal of medicinal chemistry, 2003, Dec-18, Volume: 46, Issue:26

    Topics: Acridines; Antineoplastic Agents; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; DNA; DNA, Superhelical; Electrophoresis, Agar Gel; Flow Cytometry; G2 Phase; Guanine; Humans; Hydrogen Bonding; Intercalating Agents; Kinetics; Mitosis; Structure-Activity Relationship

2003
Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells.
    Journal of natural products, 2007, Volume: 70, Issue:12

    Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Curcumin; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Humans; K562 Cells; Microscopy, Fluorescence; Molecular Structure; Reactive Oxygen Species; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Discovery of 4-anilinofuro[2,3-b]quinoline derivatives as selective and orally active compounds against non-small-cell lung cancers.
    Journal of medicinal chemistry, 2011, Jul-14, Volume: 54, Issue:13

    Topics: Administration, Oral; Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Mice; Mice, Nude; Mitosis; Models, Molecular; Neoplasm Transplantation; Oximes; Quinolines; Solubility; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution; Topoisomerase Inhibitors; Transplantation, Heterologous

2011
Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity.
    European journal of medicinal chemistry, 2012, Volume: 52

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; Drug Design; Humans; Naphthyridines; Nucleic Acid Conformation; Plasmids; Pyridines; Pyridones; Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase IIα catalytic inhibitor with low DNA damage.
    European journal of medicinal chemistry, 2013, Volume: 69

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Biocatalysis; Cell Line, Tumor; Cell Proliferation; DNA Damage; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Structure-Activity Relationship; Topoisomerase II Inhibitors; Xanthones

2013
Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity.
    European journal of medicinal chemistry, 2013, Volume: 69

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chalcone; Ciprofloxacin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Piperazines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2013
Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2.
    European journal of medicinal chemistry, 2015, Mar-06, Volume: 92

    Topics: Cell Line; Cell Proliferation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Models, Molecular; Molecular Structure; Phenanthrenes; Quinolizidines; Sirtuin 2; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2015
Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors.
    European journal of medicinal chemistry, 2017, Jan-05, Volume: 125

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Humans; Molecular Docking Simulation; Pyridines; Structure-Activity Relationship; Topoisomerase II Inhibitors

2017
Fluorescein hydrazones: A series of novel non-intercalative topoisomerase IIα catalytic inhibitors induce G1 arrest and apoptosis in breast and colon cancer cells.
    European journal of medicinal chemistry, 2017, Jan-05, Volume: 125

    Topics: Animals; Antigens, Neoplasm; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Fluorescein; G1 Phase Cell Cycle Checkpoints; Humans; Hydrazones; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2017
Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor.
    European journal of medicinal chemistry, 2017, Feb-15, Volume: 127

    Topics: Antineoplastic Agents; Apoptosis; Benzofurans; Biocatalysis; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Design; Humans; Pyridines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2017
Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity.
    European journal of medicinal chemistry, 2017, Jun-16, Volume: 133

    Topics: Antineoplastic Agents; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Halogenation; Humans; Neoplasms; Pyridines; Topoisomerase II Inhibitors

2017
Synthesis and biological research of novel azaacridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors.
    Bioorganic & medicinal chemistry, 2017, 07-01, Volume: 25, Issue:13

    Topics: Acridines; Antineoplastic Agents; Apoptosis; Aza Compounds; Binding Sites; Cell Line; Cell Proliferation; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Ligands; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Topoisomerase II Inhibitors

2017
Design, synthesis and biological evaluation of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer therapy.
    European journal of medicinal chemistry, 2017, Sep-29, Volume: 138

    Topics: Acridines; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; DNA Topoisomerases; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Structure-Activity Relationship; Topoisomerase Inhibitors; Tumor Cells, Cultured

2017
Design, synthesis, and biological evaluation of 1,3-diarylisoquinolines as novel topoisomerase I catalytic inhibitors.
    European journal of medicinal chemistry, 2018, Jan-01, Volume: 143

    Topics: Antineoplastic Agents; Biocatalysis; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Isoquinolines; Molecular Structure; Polymerization; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tubulin

2018
Neutral Porphyrin Derivative Exerts Anticancer Activity by Targeting Cellular Topoisomerase I (Top1) and Promotes Apoptotic Cell Death without Stabilizing Top1-DNA Cleavage Complexes.
    Journal of medicinal chemistry, 2018, 02-08, Volume: 61, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Biocatalysis; DNA Breaks; DNA Cleavage; DNA Topoisomerases, Type I; Humans; MCF-7 Cells; Porphyrins; Reactive Oxygen Species; Topoisomerase I Inhibitors

2018
Synthesis of carbazole derivatives containing chalcone analogs as non-intercalative topoisomerase II catalytic inhibitors and apoptosis inducers.
    European journal of medicinal chemistry, 2018, Feb-10, Volume: 145

    Topics: Antineoplastic Agents; Apoptosis; Biocatalysis; Carbazoles; Cell Cycle Checkpoints; Cell Proliferation; Chalcone; DNA Cleavage; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Molecular Structure; Plasmids; Structure-Activity Relationship; Topoisomerase II Inhibitors

2018
Design, synthesis and anticancer evaluation of acridine hydroxamic acid derivatives as dual Topo and HDAC inhibitors.
    Bioorganic & medicinal chemistry, 2018, 08-07, Volume: 26, Issue:14

    Topics: Acridines; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Topoisomerase Inhibitors; U937 Cells

2018
A new phenolic series of indenopyridinone as topoisomerase inhibitors: Design, synthesis, and structure-activity relationships.
    Bioorganic & medicinal chemistry, 2018, 10-01, Volume: 26, Issue:18

    Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Indenes; Molecular Structure; Phenols; Pyridones; Structure-Activity Relationship; Topoisomerase Inhibitors

2018
Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases.
    European journal of medicinal chemistry, 2019, Mar-01, Volume: 165

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; DNA; Humans; Indoles; Molecular Docking Simulation; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2019
Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity.
    Journal of medicinal chemistry, 2019, 04-11, Volume: 62, Issue:7

    Topics: Antineoplastic Agents; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA Topoisomerases, Type I; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Point Mutation; Topoisomerase I Inhibitors

2019
Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2-
    Journal of medicinal chemistry, 2019, 09-12, Volume: 62, Issue:17

    Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Breast Neoplasms; Cell Proliferation; Cell Survival; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Female; Humans; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred ICR; Microwaves; Molecular Structure; Pyridines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tumor Cells, Cultured

2019
Design, synthesis and biological research of novel N-phenylbenzamide-4-methylamine acridine derivatives as potential topoisomerase I/II and apoptosis-inducing agents.
    Bioorganic & medicinal chemistry letters, 2019, 12-01, Volume: 29, Issue:23

    Topics: Apoptosis; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Humans; Methylamines; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship

2019
Inhibition of cytotoxic T lymphocyte-induced target cell DNA fragmentation, but not lysis, by inhibitors of DNA topoisomerases I and II.
    The Journal of experimental medicine, 1992, Jan-01, Volume: 175, Issue:1

    Topics: Amsacrine; Animals; Camptothecin; Cells, Cultured; Cytotoxicity, Immunologic; DNA; DNA Damage; Female; Killer Cells, Natural; Lymphocyte Depletion; Lymphocytic choriomeningitis virus; Male; Mice; Mice, Inbred Strains; T-Lymphocytes, Cytotoxic; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1992
Synergistic induction of erythroid differentiation of mouse erythroleukemia (MEL) cells by inhibitors of topoisomerases and protein tyrosine kinases.
    Experimental cell research, 1992, Volume: 199, Issue:2

    Topics: Acetamides; Amsacrine; Animals; Blotting, Western; Camptothecin; Cell Differentiation; Cinnamates; Dimethyl Sulfoxide; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice; Mitomycin; Protein-Tyrosine Kinases; Sulfides; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Vanadates

1992
Inhibitors of topoisomerases do not block the passage of human lymphocyte chromosomes through mitosis.
    Journal of cell science, 1992, Volume: 103 ( Pt 1)

    Topics: Amsacrine; Camptothecin; Chromosome Aberrations; Chromosomes, Human; Daunorubicin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Ellipticines; Ethidium; Etoposide; Humans; In Vitro Techniques; Lymphocytes; Mitosis; Mitoxantrone; Nalidixic Acid; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1992
Cell cycle effects of the DNA topoisomerase inhibitors camptothecin and m-AMSA in lymphoblastoid cell lines from patients with Fanconi anemia.
    Mutation research, 1992, Nov-16, Volume: 270, Issue:2

    Topics: Amsacrine; Bromodeoxyuridine; Camptothecin; Cell Line; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Fanconi Anemia; Flow Cytometry; G2 Phase; Humans; Lymphocytes; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1992
Micronucleus induction by camptothecin and amsacrine in bone marrow of male and female CD-1 mice.
    Mutagenesis, 1992, Volume: 7, Issue:3

    Topics: Amsacrine; Animals; Bone Marrow; Camptothecin; Female; Male; Mice; Micronucleus Tests; Sex Characteristics

1992
Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus.
    Biochemistry, 1991, Jun-18, Volume: 30, Issue:24

    Topics: Amsacrine; Animals; Antibiotics, Antineoplastic; Benz(a)Anthracenes; Camptothecin; Cattle; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Bacterial; Doxorubicin; Escherichia coli; Kinetics; Plasmids; Thymus Gland

1991
Inhibition of replicon initiation in human cells following stabilization of topoisomerase-DNA cleavable complexes.
    Molecular and cellular biology, 1991, Volume: 11, Issue:7

    Topics: Amsacrine; Ataxia Telangiectasia; Camptothecin; Cell Line; DNA; DNA Damage; DNA Replication; Drug Resistance; Humans; Kinetics; Replicon; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Xeroderma Pigmentosum

1991
A shuttle vector for analysis of illegitimate recombination in mammalian cells: effects of DNA topoisomerase inhibitors on deletion frequency.
    Gene, 1991, May-30, Volume: 101, Issue:2

    Topics: Amsacrine; Animals; Camptothecin; Cell Line; Chromosome Deletion; DNA Topoisomerases, Type II; Genetic Vectors; Mutation; Plasmids; Recombination, Genetic; Restriction Mapping; Teniposide; Topoisomerase II Inhibitors

1991
The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells.
    Experimental cell research, 1991, Volume: 195, Issue:2

    Topics: Amsacrine; Camptothecin; Cell Cycle; DNA; Humans; Kinetics; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1991
Fluorometric assays for DNA topoisomerases and topoisomerase-targeted drugs: quantitation of catalytic activity and DNA cleavage.
    Molecular pharmacology, 1991, Volume: 40, Issue:4

    Topics: Amsacrine; Animals; Antineoplastic Agents; Camptothecin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Circular; DNA, Single-Stranded; DNA, Superhelical; Ethidium; Fluorescence; Fluorometry; Hydrogen-Ion Concentration; Kinetics; Novobiocin; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1991
Polyploidy induction as a consequence of topoisomerase inhibition. A flow cytometric assessment.
    Biochemical pharmacology, 1991, Nov-06, Volume: 42, Issue:11

    Topics: Amsacrine; Animals; Camptothecin; Doxorubicin; Flow Cytometry; Friend murine leukemia virus; G2 Phase; Leukemia, Erythroblastic, Acute; Mice; Polyploidy; Teniposide; Thymidine; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1991
Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons.
    Cancer research, 1990, Nov-01, Volume: 50, Issue:21

    Topics: Amsacrine; Animals; Antibiotics, Antineoplastic; Aphidicolin; Camptothecin; Cell Survival; Cricetinae; Cricetulus; Cycloheximide; Deoxyadenosines; Dichlororibofuranosylbenzimidazole; Diterpenes; DNA; Etoposide; Mutagens; Nucleic Acids; RNA; Time Factors; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1990
Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.
    Cancer research, 1991, Feb-15, Volume: 51, Issue:4

    Topics: Amsacrine; Aphidicolin; Blotting, Western; Camptothecin; Colony-Forming Units Assay; Cycloheximide; Daunorubicin; Deoxyadenosines; Dichlororibofuranosylbenzimidazole; Diterpenes; DNA Polymerase II; DNA Replication; Drug Synergism; Etoposide; Female; Humans; Leukemia, Promyelocytic, Acute; Mutagens; RNA; Topoisomerase II Inhibitors; Topotecan; Tumor Cells, Cultured

1991
Camptothecin, teniposide, or 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells.
    Cancer research, 1991, Feb-15, Volume: 51, Issue:4

    Topics: Amsacrine; Camptothecin; Cell Line; DNA; Doxorubicin; Humans; In Vitro Techniques; Leukemia, Myeloid; Mitoxantrone; S Phase; Teniposide

1991
Potentiation of topoisomerase inhibitor-induced DNA strand breakage and cytotoxicity by tumor necrosis factor: enhancement of topoisomerase activity as a mechanism of potentiation.
    Cancer research, 1990, May-01, Volume: 50, Issue:9

    Topics: Amsacrine; Animals; Camptothecin; Cell Survival; DNA Damage; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Synergism; Mice; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1990
DNA topoisomerase I as a site of action for 10-hydroxycamptothecin in human promyelocytic leukemia cells.
    Cancer biochemistry biophysics, 1990, Volume: 11, Issue:1

    Topics: Amsacrine; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Division; DNA Damage; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance; Enzyme Inhibitors; Etoposide; Humans; Leukemia, Promyelocytic, Acute; Mutation; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1990
Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro.
    Mutagenesis, 1990, Volume: 5, Issue:6

    Topics: Amsacrine; Animals; Bone Marrow; Bone Marrow Cells; Camptothecin; Cell Line; Chromatids; Chromosome Aberrations; Dose-Response Relationship, Drug; Gene Rearrangement; In Vitro Techniques; Lymphocytes; Lymphoma; Male; Mice; Mice, Inbred C57BL; Mutagens; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1990
Overproduction of topoisomerase II in an ataxia telangiectasia fibroblast cell line: comparison with a topoisomerase II-overproducing hamster cell mutant.
    Nucleic acids research, 1989, Feb-25, Volume: 17, Issue:4

    Topics: Amsacrine; Animals; Ataxia Telangiectasia; Blotting, Western; Camptothecin; Cell Line; Cell Survival; Cricetinae; DNA Replication; DNA Topoisomerases, Type II; Fibroblasts; Humans; Kinetics; Mutation

1989
In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone.
    Cancer research, 1989, May-15, Volume: 49, Issue:10

    Topics: Amsacrine; Animals; Antineoplastic Agents; Camptothecin; DNA; DNA Damage; Leukemia, Experimental; Mice; Teniposide; Thiobarbiturates; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1989
Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells.
    Cancer research, 1989, Nov-15, Volume: 49, Issue:22

    Topics: Amsacrine; Animals; Aphidicolin; Camptothecin; Cell Line; Cell Survival; Cricetinae; Cricetulus; Diterpenes; DNA Replication; Etoposide; Hydroxyurea; Kinetics; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1989
Nonproductive rearrangement of DNA topoisomerase I and II genes: correlation with resistance to topoisomerase inhibitors.
    Journal of the National Cancer Institute, 1989, Nov-15, Volume: 81, Issue:22

    Topics: Alleles; Amsacrine; Animals; Camptothecin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance; Gene Expression Regulation; Gene Rearrangement; Leukemia P388; Leukemia, Experimental; Methylation; Methyltransferases; Mice; RNA, Messenger; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transcription, Genetic

1989
Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.
    Cancer research, 1988, Feb-01, Volume: 48, Issue:3

    Topics: Amsacrine; Animals; Camptothecin; Cell Line; Cell Survival; Chromosome Aberrations; Cricetinae; Drug Resistance; Ellipticines; Etoposide; Mitomycin; Mitomycins; Sister Chromatid Exchange; Topoisomerase II Inhibitors

1988
Induction of sister chromatid exchanges by inhibitors of topoisomerases.
    Cell biology and toxicology, 1986, Volume: 2, Issue:4

    Topics: Amsacrine; Animals; Camptothecin; Cells, Cultured; Cricetinae; DNA Topoisomerases, Type I; Enzyme Inhibitors; Fibroblasts; Podophyllotoxin; Sister Chromatid Exchange; Teniposide

1986
Role for topoisomerases in the release of DNA into the detergent-soluble fraction of eukaryotic cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:16

    Topics: Aminoacridines; Amsacrine; Animals; Camptothecin; Detergents; DNA; DNA Topoisomerases, Type I; Intercalating Agents; Kinetics; Mice; Novobiocin; Solubility; Spleen; Teniposide; Thymidine

1986
Topoisomerase inhibitors can selectively interfere with different stages of simian virus 40 DNA replication.
    Molecular and cellular biology, 1986, Volume: 6, Issue:12

    Topics: Amsacrine; Animals; Antineoplastic Agents; Camptothecin; Cell Line; Chlorocebus aethiops; DNA Replication; DNA, Viral; Doxorubicin; Ellipticines; Kidney; Kinetics; Nucleic Acid Conformation; Simian virus 40; Topoisomerase I Inhibitors

1986
Selective damage to the active X chromosome by camptothecin and amsacrine as determined by an allele-specific alkaline unwinding assay.
    Biochemical pharmacology, 1995, Oct-12, Volume: 50, Issue:8

    Topics: Alleles; Amsacrine; Antineoplastic Agents, Phytogenic; Base Sequence; Camptothecin; Cell Line, Transformed; DNA; DNA Damage; Genetic Techniques; Glucosephosphate Dehydrogenase; Humans; Hydrogen-Ion Concentration; Lymphocytes; Molecular Sequence Data; X Chromosome

1995
Distinct patterns of cell cycle disturbance elicited by compounds interfering with DNA topoisomerase I and II activity.
    Experimental cell research, 1995, Volume: 218, Issue:1

    Topics: Amsacrine; Bisbenzimidazole; Camptothecin; Cell Cycle; Cell Line; Distamycins; DNA; Dose-Response Relationship, Drug; Ethidium; Flow Cytometry; Humans; Intercalating Agents; Kinetics; Lymphocytes; Netropsin; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1995
Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8.
    Mutation research, 1993, Volume: 288, Issue:2

    Topics: Amsacrine; Animals; Camptothecin; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Mutation; Sister Chromatid Exchange; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1993
Importance of replication fork progression for the induction of chromosome damage and SCE by inhibitors of DNA topoisomerases.
    Mutation research, 1993, Volume: 303, Issue:2

    Topics: Amsacrine; Animals; Aphidicolin; Camptothecin; CHO Cells; Cricetinae; DNA Damage; DNA Replication; Electrophoresis, Gel, Pulsed-Field; Karyotyping; Sister Chromatid Exchange; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1993
Altered topoisomerase I and II activities in suramin-resistant lung fibrosarcoma cells.
    Molecular pharmacology, 1995, Volume: 47, Issue:5

    Topics: Amsacrine; Animals; Camptothecin; Cell Nucleus; Cricetinae; Cricetulus; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Neoplasm; Doxorubicin; Drug Resistance; Etoposide; Fibrosarcoma; Lung Neoplasms; Neoplasm Proteins; Suramin; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1995
The influence of antibiotics and antitumor agents on the relaxation activity of Pisum sativum leaf chloroplast topoisomerase I.
    Archives of biochemistry and biophysics, 1995, Jun-20, Volume: 320, Issue:1

    Topics: Amiloride; Amsacrine; Anti-Bacterial Agents; Antineoplastic Agents; Camptothecin; Chloroplasts; DNA Topoisomerases, Type I; DNA, Plant; Ethidium; Heparin; Indoles; Magnesium; Nalidixic Acid; Novobiocin; Pisum sativum; Polyamines; Topoisomerase I Inhibitors

1995
DNA topoisomerases I & II cleavage sites in the type 1 human immunodeficiency virus (HIV-1) DNA promoter region.
    Biochemical and biophysical research communications, 1994, Dec-30, Volume: 205, Issue:3

    Topics: Amsacrine; Animals; Binding Sites; Camptothecin; Chromosome Mapping; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Viral; Genes, Viral; HIV Long Terminal Repeat; HIV-1; Humans; In Vitro Techniques; Mice; NF-kappa B; Promoter Regions, Genetic; Sp1 Transcription Factor; TATA Box; Teniposide

1994
Quantification of topoisomerase-DNA complexes in leukemia cells from patients undergoing therapy with a topoisomerase-directed agent.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:3

    Topics: Amsacrine; Antineoplastic Agents; Camptothecin; DNA Probes; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Resistance; Etoposide; Humans; Immunoblotting; Leukemia; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan; Tumor Cells, Cultured

1994
Synergistic effect of inhibitors of topoisomerase I and II on chromosome damage and cell killing in cultured Chinese hamster ovary cells.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:5

    Topics: Amsacrine; Animals; Camptothecin; Cell Death; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Damage; Drug Synergism; Electrophoresis, Agar Gel; Metaphase; Sister Chromatid Exchange; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1994
A human small cell lung carcinoma cell line, resistant to 4'-(9-acridinylamino)-methanesulfon-m-anisidide and cross-resistant to camptothecin with a high level of topoisomerase I.
    Biochemical pharmacology, 1994, Aug-30, Volume: 48, Issue:5

    Topics: Amsacrine; Base Sequence; Camptothecin; Carcinoma, Small Cell; DNA Primers; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance; Humans; Hydrogen-Ion Concentration; Lung Neoplasms; Molecular Sequence Data; RNA, Messenger; Sequence Analysis, DNA; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1994
Different modes of cell-killing action between DNA topoisomerase I and II inhibitors revealed by kinetic analysis.
    Japanese journal of cancer research : Gann, 1994, Volume: 85, Issue:2

    Topics: Amsacrine; Antineoplastic Agents; Camptothecin; Carbazoles; Cell Cycle; Colonic Neoplasms; Diterpenes; DNA Replication; Dose-Response Relationship, Drug; Etoposide; Flow Cytometry; G2 Phase; Humans; Indoles; Mitosis; Quinones; S Phase; Teniposide; Time Factors; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Stem Cell Assay

1994
A temperature sensitive topoisomerase II allele confers temperature dependent drug resistance on amsacrine and etoposide: a genetic system for determining the targets of topoisomerase II inhibitors.
    Cancer research, 1993, Jan-01, Volume: 53, Issue:1

    Topics: Alleles; Amsacrine; Camptothecin; Cell Division; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; Drug Resistance; Etoposide; Models, Biological; Saccharomyces cerevisiae; Sensitivity and Specificity; Temperature; Topoisomerase II Inhibitors

1993
Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors.
    Blood, 1993, Mar-01, Volume: 81, Issue:5

    Topics: Amsacrine; Apoptosis; Camptothecin; Cell Differentiation; DNA; DNA Damage; Etoposide; Humans; Leukemia, Promyelocytic, Acute; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tretinoin; Tumor Cells, Cultured

1993
Apoptosis of S-phase HL-60 cells induced by DNA topoisomerase inhibitors: detection of DNA strand breaks by flow cytometry using the in situ nick translation assay.
    Toxicology letters, 1993, Volume: 67, Issue:1-3

    Topics: Amsacrine; Apoptosis; Camptothecin; DNA Damage; DNA, Neoplasm; Flow Cytometry; Genetic Techniques; Humans; S Phase; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1993
Effect of topoisomerase inhibitors on the in vitro HIV DNA integration reaction.
    Biochemical and biophysical research communications, 1993, May-14, Volume: 192, Issue:3

    Topics: Amsacrine; Antineoplastic Agents; Antiviral Agents; Base Sequence; Camptothecin; Carbazoles; DNA Nucleotidyltransferases; Ellipticines; Escherichia coli; Etoposide; HIV Long Terminal Repeat; HIV-1; Integrases; Kinetics; Molecular Sequence Data; Netropsin; Oligodeoxyribonucleotides; Plasmids; Recombinant Proteins; Substrate Specificity; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1993
Suramin inhibits DNA damage in human prostate cancer cells treated with topoisomerase inhibitors in vitro.
    The Prostate, 1993, Volume: 23, Issue:1

    Topics: Amsacrine; Camptothecin; Cell Survival; Chemical Precipitation; DNA Damage; Dose-Response Relationship, Drug; Drug Interactions; Etoposide; Humans; Male; Prostatic Neoplasms; Suramin; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1993
Altered topoisomerase I activity and recombination activating gene expression in a human leukemia cell line resistant to doxorubicin.
    Biochemical pharmacology, 1993, Sep-01, Volume: 46, Issue:5

    Topics: Amsacrine; Camptothecin; Cell Line; Cell Nucleus; Cell Survival; DNA Nucleotidyltransferases; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance; Gene Expression Regulation; Genes, RAG-1; Humans; Leukemia-Lymphoma, Adult T-Cell; Recombination, Genetic; Topoisomerase II Inhibitors; Transcriptional Activation; VDJ Recombinases

1993
The sensitivity to DNA topoisomerase inhibitors in L5178Y lymphoma strains is not related to a primary defect of DNA topoisomerases.
    Carcinogenesis, 1993, Volume: 14, Issue:9

    Topics: Amsacrine; Animals; Camptothecin; DNA Damage; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Superhelical; Etoposide; Leukemia L5178; Mice; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1993
Response of purified mitochondrial DNA topoisomerase I from bovine liver to camptothecin and m-AMSA.
    Archives of biochemistry and biophysics, 1995, Dec-20, Volume: 324, Issue:2

    Topics: Amsacrine; Animals; Antineoplastic Agents; Camptothecin; Cattle; Cell Nucleus; DNA, Superhelical; Enzyme Inhibitors; Intercalating Agents; Mitochondria, Liver; Nucleic Acid Conformation; Plasmids; Teniposide; Topoisomerase I Inhibitors

1995
Sister-chromatid exchanges (SCE) induction by inhibitors of DNA topoisomerases in cultured human lymphocytes.
    Mutation research, 1996, Jul-05, Volume: 368, Issue:3-4

    Topics: Amsacrine; Camptothecin; Cells, Cultured; Enzyme Inhibitors; Etoposide; Humans; Lymphocytes; Mitomycin; Nalidixic Acid; Sister Chromatid Exchange; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1996
Sister chromatid exchange induced by DNA topoisomerases poisons in late replicating heterochromatin: influence of inhibition of replication and transcription.
    Mutation research, 1996, Jul-22, Volume: 354, Issue:2

    Topics: Amsacrine; Animals; Aphidicolin; Camptothecin; CHO Cells; Chromatin; Cricetinae; Dactinomycin; DNA Replication; Enzyme Inhibitors; Euchromatin; Heterochromatin; Isomerases; Sister Chromatid Exchange; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transcription, Genetic

1996
Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA.
    Molecular pharmacology, 1996, Volume: 50, Issue:5

    Topics: Amsacrine; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Death; DNA; DNA Damage; DNA Replication; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Etoposide; G1 Phase; Mating Factor; Peptides; S Phase; Saccharomyces cerevisiae

1996
Cytotoxic efficacy with combinations of topoisomerase I and topoisomerase II inhibitors in sensitive and multidrug-resistant L1210 mouse leukemia cells.
    Annals of the New York Academy of Sciences, 1996, Dec-13, Volume: 803

    Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Resistance, Multiple; Drug Synergism; Enzyme Inhibitors; Etoposide; Leukemia L1210; Mice; Mitoxantrone; Topoisomerase I Inhibitors; Topotecan

1996
Inhibition of DNA unwinding and ATPase activities of human DNA helicase II by chemotherapeutic agents.
    Biochemical and biophysical research communications, 1997, Jul-30, Volume: 236, Issue:3

    Topics: Adenosine Triphosphatases; Amsacrine; Antineoplastic Agents; Aphidicolin; Camptothecin; Dactinomycin; Daunorubicin; DNA; DNA Helicases; Ellipticines; Enzyme Inhibitors; Ethidium; Etoposide; Genistein; Humans; Isoflavones; Nogalamycin; Novobiocin; Topoisomerase I Inhibitors

1997
Inhibition of pea chloroplast DNA helicase unwinding and ATPase activities by DNA-interacting ligands.
    Biochemical and biophysical research communications, 1998, Mar-27, Volume: 244, Issue:3

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amsacrine; Camptothecin; Chloroplasts; Dactinomycin; Daunorubicin; DNA Helicases; Ellipticines; Ethidium; Etoposide; Genistein; Hydrolysis; Intercalating Agents; Ligands; Nogalamycin; Novobiocin; Pisum sativum

1998
Genotoxic activity of four inhibitors of DNA topoisomerases in larval cells of Drosophila melanogaster as measured in the wing spot assay.
    Mutation research, 1998, Mar-16, Volume: 413, Issue:2

    Topics: Amsacrine; Animals; Camptothecin; Drosophila melanogaster; Etoposide; Larva; Mutagens; Nalidixic Acid; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1998
Induction of apoptosis in human retinoblastoma cells by topoisomerase inhibitors.
    Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:8

    Topics: Amsacrine; Apoptosis; bcl-2-Associated X Protein; Camptothecin; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cycloheximide; Dactinomycin; DNA Damage; DNA Topoisomerases, Type I; DNA, Neoplasm; Enzyme Inhibitors; Etoposide; Humans; Insulin-Like Growth Factor Binding Protein 3; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Retinal Neoplasms; Retinoblastoma; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1998
Apoptotic effects of different drugs on cultured retinoblastoma Y79 cells.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 1998, Volume: 19, Issue:5

    Topics: Amsacrine; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Butyrates; Butyric Acid; Camptothecin; Carboplatin; Cisplatin; DNA Damage; Drug Screening Assays, Antitumor; Etoposide; Humans; Paclitaxel; Retinoblastoma; Suramin; Tumor Cells, Cultured

1998
Enhanced sensitivity to topoisomerase inhibitors in synchronous CHO cells pre-treated with 5-azacytidine.
    Mutation research, 1998, Oct-12, Volume: 421, Issue:1

    Topics: Amsacrine; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Azacitidine; Camptothecin; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Methylation; Drug Interactions; Enzyme Inhibitors; S Phase; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1998
Increased cyclin E level in retinoblastoma cells during programmed cell death.
    Cellular and molecular biology (Noisy-le-Grand, France), 1998, Volume: 44, Issue:8

    Topics: Amsacrine; Apoptosis; Camptothecin; Cyclin A; Cyclin E; Enzyme Inhibitors; Etoposide; Humans; Interleukin-1; Retinoblastoma; Sphingosine; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1998
Mechanism of cytotoxicity of N-[2-(dimethylamino)ethyl] acridine-4-carboxamide and of its 7-chloro derivative: the roles of topoisomerases I and II.
    Cancer chemotherapy and pharmacology, 1999, Volume: 43, Issue:4

    Topics: Acridines; Amsacrine; Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Survival; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Enzyme Inhibitors; Humans; Kinetics; Lung Neoplasms; Mice; Models, Chemical; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Stem Cell Assay

1999
Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I.
    The Journal of biological chemistry, 2000, Nov-17, Volume: 275, Issue:46

    Topics: Amsacrine; Antineoplastic Agents; Camptothecin; Cell Division; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Fungal Proteins; Humans; Microbial Sensitivity Tests; Microscopy, Fluorescence; Mutation; Nuclear Proteins; Protein Binding; Protein Structure, Tertiary; Protein Transport; Recombinant Fusion Proteins; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Subcellular Fractions; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transformation, Genetic

2000
Analysis of cleavage complexes using reactive inhibitor derivatives.
    Methods in molecular biology (Clifton, N.J.), 2001, Volume: 95

    Topics: Alkylation; Amsacrine; Animals; Bacteriophage T4; Base Sequence; Binding Sites; Camptothecin; Cattle; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Humans; Intercalating Agents; Light; Molecular Structure; Oligodeoxyribonucleotides; Photochemistry; Placenta; Protein Binding; Thymus Gland; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2001
Cell-cycle analysis of drug-treated cells.
    Methods in molecular biology (Clifton, N.J.), 2001, Volume: 95

    Topics: Acids; Amsacrine; Antineoplastic Agents; Bromodeoxyuridine; Camptothecin; Cell Cycle; Cyclins; DNA; Flow Cytometry; Fluorescent Dyes; HL-60 Cells; Hot Temperature; Humans; Immunohistochemistry; Nucleic Acid Denaturation; Topoisomerase I Inhibitors

2001
Paclitaxel sensitization of multidrug-resistant cells to chemotherapy is independent of the cell cycle.
    Cytometry, 2001, Mar-01, Volume: 43, Issue:3

    Topics: Amsacrine; Antineoplastic Agents; Camptothecin; Carcinoma, Small Cell; Cell Cycle; Cell Survival; Chlorambucil; Cisplatin; Daunorubicin; Drug Resistance, Multiple; Epirubicin; Genistein; Humans; Lung Neoplasms; Paclitaxel; Tumor Cells, Cultured; Vinblastine; Vinorelbine

2001
Is MutaMouse insensitive to clastogens?
    Mutation research, 2008, Apr-30, Volume: 652, Issue:2

    Topics: Amsacrine; Animals; Bleomycin; Camptothecin; DNA Damage; Dose-Response Relationship, Drug; Lac Operon; Male; Mice; Mice, Transgenic; Micronucleus Tests; Mutagenicity Tests; Mutagens

2008
Detecting genotoxic effects of potential clastogens: an in vivo study using the transgenic lacZ plasmid and the MutaMouse model.
    Mutation research, 2008, Apr-30, Volume: 652, Issue:2

    Topics: Amsacrine; Animals; Bleomycin; Camptothecin; Ethylnitrosourea; Genes, Reporter; Lac Operon; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Micronucleus Tests; Mutagenicity Tests; Mutagens; Plasmids

2008