amsacrine and azacitidine

amsacrine has been researched along with azacitidine in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19909 (33.33)18.7374
1990's14 (51.85)18.2507
2000's3 (11.11)29.6817
2010's1 (3.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Belt, J; Brenner, MK; Crom, W; Hurwitz, CA; Krance, R; Mahmoud, H; Ribeirio, R; Roberts, WM; Santana, VM; Schell, MJ1
Gray, RG; Rees, JK1
Fiere, D; Haanen, C; Jehn, U; Löwenberg, B; Peetermans, M; Solbu, G; Stryckmans, P; Suciu, S; Willemze, R; Zittoun, R1
Heinemann, V; Jehn, U1
Colly, LP; Kluin-Nelemans, JC; Richel, DJ; Willemze, R1
Camitta, B; Holbrook, T; Krischer, J; Land, VJ; Sexauer, C; Steuber, CP1
Estey, E; Silberman, L; Zwelling, LA1
Glick, JH; Kahn, SB; Knospe, WH; Soojian, M; Spiers, A1
Catovsky, D; Chessells, JM; Galton, DA; Goldman, JM; Hann, IM; Hoffbrand, AV; Marcus, RE; Newland, AC; Prentice, HG; Stevens, RF1
Gray, R; Hayhoe, FG; Rees, JK1
Jehn, U; Zittoun, R1
Cabanillas, F1
Carella, AM; Marmont, AM; Santini, G1
Brodsky, I; Bulova, S; Conroy, JF; Kahn, SB; Lebedda, J; Sklaroff, R1
Gahrton, G1
Jehn, U1
Bartolucci, AA; Moore, JO; Omura, GA; Stagg, M; Volger, WR; Weiner, RS1
Doré, BT; Labiberté, J; Momparler, LF; Momparler, RL1
Archimbaud, E; Muus, P; Willemze, R1
Camitta, B; Holbrook, T; Krischer, J; Land, V; Mahoney, D; Sexauer, C; Steuber, CP; Weinstein, H1
Eckert, I; Schulz, WA; Stopper, H; Wagener, P1
Archimbaud, E; Berneman, Z; Dardenne, M; Dohner, H; Jaksic, B; Jehn, U; Labar, B; Louwagie, EA; Muus, P; Stryckmans, P; Suciu, S; Tjean, M; Wijermans, P; Willemze, R; Zittoun, R1
Cortés, F; López-Baena, M; Mateos, S; Piñero, J1
Cantero, G; Cortés, F; Domínguez, I; Mateos, S; Pastor, N1
Aung, L; Kirk, RC; Liang, S; Quah, TC; Tan, RM; Yeoh, AE1

Reviews

2 review(s) available for amsacrine and azacitidine

ArticleYear
Intercalator-induced, topoisomerase II-mediated DNA cleavage and its modification by antineoplastic antimetabolites.
    International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:7

    Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Azacitidine; Cell Survival; Cytarabine; DNA; DNA Topoisomerases, Type II; Drug Synergism; Humans; Hydroxyurea; In Vitro Techniques; Intercalating Agents; Mice

1986
Treatment of acute leukemia--advances in chemotherapy, immunotherapy, and bone marrow transplantation.
    Advances in cancer research, 1983, Volume: 40

    Topics: Aclarubicin; Acute Disease; Adolescent; Adult; Age Factors; Aminoacridines; Amsacrine; Anthraquinones; Antibodies, Monoclonal; Azacitidine; Bone Marrow Transplantation; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Humans; Ifosfamide; Immunotherapy; Infant; Interferons; Leukemia; Leukemia, Lymphoid; Liposomes; Middle Aged; Mitoxantrone; Naphthacenes; Prognosis; Teniposide; Transplantation, Homologous; Transplantation, Isogeneic; Vinblastine; Vindesine

1983

Trials

13 trial(s) available for amsacrine and azacitidine

ArticleYear
Current strategies for treatment of acute myeloid leukemia at St Jude Children's Research Hospital.
    Leukemia, 1992, Volume: 6 Suppl 2

    Topics: 2-Chloroadenosine; Acute Disease; Adolescent; Adult; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Child; Child, Preschool; Cladribine; Cytarabine; Daunorubicin; Deoxyadenosines; Etoposide; Humans; Infant; Leukemia, Myeloid, Acute; Remission Induction

1992
Remission induction and postremission therapy in acute myelogenous leukemia: British MRC Study.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Marrow Transplantation; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dacarbazine; Daunorubicin; Doxorubicin; Drug Combinations; Etoposide; Humans; Leukemia, Myeloid, Acute; Middle Aged; Mitoxantrone; Multicenter Studies as Topic; Nimustine; Prednisone; Randomized Controlled Trials as Topic; Remission Induction; Survival Rate; Thioguanine; United Kingdom; Vincristine

1990
A randomized comparison of intensive maintenance treatment for adult acute myelogenous leukemia using either cyclic alternating drugs or repeated courses of the induction-type chemotherapy: AML-6 trial of the EORTC Leukemia Cooperative Group.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Belgium; Bone Marrow Transplantation; Child; Combined Modality Therapy; Cytarabine; Daunorubicin; France; Humans; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Vincristine

1990
Intermediate-dose Ara-C/m-AMSA for remission induction and high-dose Ara-C/m-AMSA for intensive consolidation in relapsed and refractory adult acute myelogeneous leukemia.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Marrow Transplantation; Combined Modality Therapy; Cytarabine; Daunorubicin; Germany, West; Humans; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Middle Aged; Randomized Controlled Trials as Topic; Remission Induction; Survival Rate

1990
Toxicity trials of amsacrine (AMSA) and etoposide +/- azacitidine (AZ) in childhood acute non-lymphocytic leukemia (ANLL): a pilot study.
    Investigational new drugs, 1991, Volume: 9, Issue:2

    Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Child; Child, Preschool; Etoposide; Female; Humans; Infant; Leukemia, Myeloid, Acute; Male; Pilot Projects

1991
Intensive induction and consolidation chemotherapy for adults and children with acute myeloid leukaemia (AML) joint AML trial 1982-1985.
    Haematology and blood transfusion, 1987, Volume: 30

    Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Child; Clinical Trials as Topic; Cytarabine; Daunorubicin; Etoposide; Female; Humans; Leukemia, Myeloid, Acute; Male; Random Allocation; Remission Induction; Risk; Thioguanine; United Kingdom

1987
The ninth British Medical Research Council trial for the treatment of acute myeloid leukaemia.
    Haematology and blood transfusion, 1987, Volume: 30

    Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Combinations; England; Etoposide; Humans; Leukemia, Myeloid, Acute; Prednisone; Remission Induction; Thioguanine; Vincristine

1987
[AML-6 study of the value of cyclic alternating chemotherapy during remission in acute myelocytic leukemia].
    Onkologie, 1985, Volume: 8, Issue:2

    Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Clinical Trials as Topic; Cytarabine; Daunorubicin; Drug Administration Schedule; Humans; Leukemia, Myeloid, Acute; Middle Aged; Vincristine

1985
[Current status of the treatment of recurrent acute myeloblastic leukaemia in adults (author's transl)].
    Sangre, 1981, Volume: 26, Issue:5B

    Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Azacitidine; Clinical Trials as Topic; Daunorubicin; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Etoposide; Humans; Leukemia, Myeloid, Acute; Mitoguazone; Recurrence

1981
Long-term outcome of postremission chemotherapy for adults with acute myeloid leukemia using different dose-intensities.
    Leukemia & lymphoma, 1994, Volume: 15, Issue:1-2

    Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Marrow Transplantation; Combined Modality Therapy; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Germany; Humans; Leukemia, Myeloid; Life Tables; Male; Middle Aged; Opportunistic Infections; Patient Acceptance of Health Care; Preleukemia; Prospective Studies; Remission Induction; Salvage Therapy; Survival Analysis; Treatment Outcome; Vincristine

1994
Long-term follow-up of a randomized post-induction therapy trial in acute myelogenous leukemia (a Southeastern Cancer Study Group trial).
    Leukemia, 1995, Volume: 9, Issue:9

    Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cytarabine; Daunorubicin; Female; Follow-Up Studies; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Patient Selection; Remission Induction; Thioguanine

1995
Therapy of refractory or recurrent childhood acute myeloid leukemia using amsacrine and etoposide with or without azacitidine: a Pediatric Oncology Group randomized phase II study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:5

    Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Child; Child, Preschool; Dose-Response Relationship, Drug; Etoposide; Female; Humans; Infant; Leukemia, Myeloid, Acute; Male; Neoplasm Recurrence, Local

1996
A randomized phase II study on the effects of 5-Aza-2'-deoxycytidine combined with either amsacrine or idarubicin in patients with relapsed acute leukemia: an EORTC Leukemia Cooperative Group phase II study (06893).
    Leukemia, 1997, Volume: 11 Suppl 1

    Topics: Adolescent; Adult; Aged; Amsacrine; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Decitabine; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Idarubicin; Leukemia, Myeloid, Acute; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Survival Rate; Time Factors

1997

Other Studies

12 other study(ies) available for amsacrine and azacitidine

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
The antileukaemic activity of 5-Aza-2 deoxycytidine (Aza-dC) in patients with relapsed and resistant leukaemia.
    British journal of cancer, 1991, Volume: 64, Issue:1

    Topics: Acute Disease; Adult; Amsacrine; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Marrow; Decitabine; Drug Resistance; Female; Humans; Leukemia; Male; Middle Aged; Recurrence

1991
Amsacrine [4'-(9-acridinylamino)-methanesulfon-m-anisidide] (m-AMSA) and 5-azacytidine (AZA) for remission reinduction in patients with relapsed adult acute nonlymphocytic leukemia. An ECOG pilot study. Eastern Cooperative Oncology Group.
    American journal of clinical oncology, 1987, Volume: 10, Issue:1

    Topics: Acute Disease; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Drug Evaluation; Female; Heart; Humans; Leukemia; Male; Middle Aged; Pilot Projects

1987
Amsacrine and 5-azacytidine in acute non lymphatic leukaemia (ANLL).
    Haematologica, 1982, Volume: 67, Issue:5

    Topics: Acute Disease; Adult; Aminoacridines; Amsacrine; Azacitidine; Humans; Leukemia

1982
4'-(9-acridinylamino)methane-sulfon-m-anisidide (m-AMSA) and 5-azacytidine (AZA) in the treatment of relapsed adult acute leukemia.
    American journal of clinical oncology, 1983, Volume: 6, Issue:4

    Topics: Acute Disease; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Azacitidine; Drug Therapy, Combination; Female; Humans; Leukemia; Male; Middle Aged; Prognosis; Recurrence

1983
Interaction of 5-aza-2'-deoxycytidine with amsacrine or 1,25-dihydroxyvitamin D3 on HL-60 myeloid leukemic cells and inhibitors of cytidine deaminase.
    Leukemia, 1993, Volume: 7 Suppl 1

    Topics: Amsacrine; Antineoplastic Agents; Azacitidine; Calcitriol; Decitabine; Drug Interactions; Drug Screening Assays, Antitumor; Humans; Leukemia, Myeloid; Time Factors; Tumor Cells, Cultured; Tumor Stem Cell Assay

1993
Preliminary results with 5-aza-2'-deoxycytidine (DAC)-containing chemotherapy in patients with relapsed or refractory acute leukemia. The EORTC Leukemia Cooperative Group.
    Leukemia, 1993, Volume: 7 Suppl 1

    Topics: Acute Disease; Adolescent; Adult; Aged; Amsacrine; Antineoplastic Agents; Azacitidine; Decitabine; Female; Humans; Idarubicin; Leukemia, Myeloid; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction

1993
Formation of micronuclei and inhibition of topoisomerase II in the comet assay in mammalian cells with altered DNA methylation.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1997, Volume: 143

    Topics: Amsacrine; Animals; Azacitidine; Carcinoma, Embryonal; Cell Differentiation; DNA Methylation; DNA, Neoplasm; Enzyme Inhibitors; Ethyl Methanesulfonate; In Situ Hybridization; Kinetochores; Leukemia L5178; Mammals; Mice; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagens; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1997
Enhanced sensitivity to topoisomerase inhibitors in synchronous CHO cells pre-treated with 5-azacytidine.
    Mutation research, 1998, Oct-12, Volume: 421, Issue:1

    Topics: Amsacrine; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Azacitidine; Camptothecin; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Methylation; Drug Interactions; Enzyme Inhibitors; S Phase; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1998
The DNA demethylating 5-azaC induces endoreduplication in cultured Chinese hamster cells.
    Mutation research, 2005, Oct-15, Volume: 578, Issue:1-2

    Topics: Amsacrine; Animals; Antineoplastic Agents; Azacitidine; CHO Cells; Chromosome Segregation; Chromosomes; Cricetinae; Cricetulus; DNA; DNA Damage; DNA Replication; DNA Restriction Enzymes; Dose-Response Relationship, Drug; Electrophoresis, Gel, Pulsed-Field; Methylation; Topoisomerase II Inhibitors

2005
Improved outcome in childhood acute myeloid leukemia in Singapore with the MRC AML 10 protocol.
    Pediatric blood & cancer, 2007, Volume: 48, Issue:3

    Topics: Acute Disease; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cytarabine; Daunorubicin; Developing Countries; Disease-Free Survival; Drug Evaluation; Etoposide; Female; Gastrointestinal Diseases; Heart Diseases; Hematologic Diseases; Humans; Infant; Infections; Kaplan-Meier Estimate; Leukemia, Myeloid; Male; Mercaptopurine; Methotrexate; Mitoxantrone; Prednisone; Remission Induction; Retrospective Studies; Singapore; Survival Analysis; Thioguanine; Treatment Outcome; Vincristine

2007