amsacrine has been researched along with acridines in 43 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (23.26) | 18.7374 |
| 1990's | 21 (48.84) | 18.2507 |
| 2000's | 8 (18.60) | 29.6817 |
| 2010's | 3 (6.98) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Jenkins, TC; McConnaughie, AW | 1 |
| Infante Lara, L; Laradji, A; Okoro, CO; Osheroff, N; Sledge, A | 1 |
| Baguley, BC; Ferguson, LR; Iwamoto, Y; Pearson, A | 1 |
| Cornford, EM; Paxton, JW; Young, D | 1 |
| Baguley, BC; Finlay, GJ; Gavin, JB; Haldane, A | 1 |
| Baguley, BC; Finlay, GJ | 2 |
| Graves, DE; Wadkins, RM | 1 |
| Baguley, BC; Ferguson, LR; Hill, CM | 1 |
| Kato, A; Kimura, M; Okabayashi, I | 1 |
| Baguley, BC; Ching, LM; Darkin, SJ; Lawson, PA; Ralph, RK; Schneider, E | 1 |
| Chen, GL; Hsiang, YH; Liu, LF; Rowe, TC | 1 |
| Baguley, BC; Ferguson, LR | 1 |
| Baguley, BC; Davis, LM; Harvey, JD | 1 |
| Atwell, GJ; Baguley, BC; Denny, WA; Finlay, GJ; Rewcastle, GW | 1 |
| Baguley, BC; Wakelin, LP; Waring, MJ; Wilson, WR | 1 |
| Ferguson, LR; MacPhee, DG | 1 |
| Baguley, BC; Denny, WA; Robertson, IG | 1 |
| Kimura, M | 1 |
| Beerman, TA; Denny, WA; McCarthy, K; Reynolds, B; Woynarowski, JM | 1 |
| Baguley, BC; Finlay, GJ; Haldane, A; Holdaway, KM | 1 |
| Baguley, BC; Finlay, GJ; Haldane, A | 1 |
| Bland, TJ; Robertson, IG | 1 |
| Baguley, BC; Finlay, GJ; Riou, JF | 1 |
| Baguley, BC; Davey, MW; Davey, RA; Hargrave, RM; Harvie, RM; Su, GM | 1 |
| Baguley, BC; Bridewell, DJ; Finlay, GJ | 1 |
| Fischer, G; Pindur, U | 1 |
| Madden, B; McClean, S; McGown, AT; Searcey, M; Wakelin, LP | 1 |
| Bastow, KF; Vance, JR | 1 |
| Adams, A; Collyer, CA; Denny, WA; Guss, JM; Wakelin, LP | 1 |
| Austin, CA; Baguley, BC; Finlay, GJ; Lock, RB; Meczes, EL; Perenna Rogers, M; Sullivan, DM; Turnbull, RM | 1 |
| Austin, CA; Baguley, BC; Errington, F; Li, G; Li, L; Li, W; Tilby, MJ; Willmore, E | 1 |
| Beal, PA; Carlson, CB | 1 |
| Baccichetti, F; Bordin, F; Chiarelotto, G; Ferlin, MG; Marzano, C | 1 |
| Chen, IL; Chen, YL; Lu, CM; Tsao, LT; Wang, JP | 1 |
| Baguley, BC; Jacintho, JD; Kovacic, P; Wakelin, LP | 1 |
| Gueorguieva, M; Schloffer, D; Skladanowski, A; Uhl, M; Wesierska-Gadek, J | 1 |
| Austin, CA; Gilroy, KL; Lakey, JH; Leontiou, C; Padget, K | 1 |
| Dzierzbicka, K; Kukowska-Kaszuba, M | 1 |
| Chen, YT; Chou, TC; Kakadiya, R; Kapuriya, K; Kapuriya, N; Lee, TC; Naliapara, Y; Shah, A; Su, TL; Tsai, TH; Wu, YT; Zhang, X | 1 |
| Barros, FW; Bezerra, DP; Costa-Lotufo, LV; da Rocha Pitta, MG; de Abreu, FC; de Lima, Mdo C; de Moraes, MO; de Moura, MA; Galdino, SL; Goulart, MO; Pessoa, C; Pitta, Ida R; Silva, TG | 1 |
| Li, S; Luo, T; Wang, C; Wang, J; Zhao, J; Zhhang, Y | 1 |
| Kozurkova, M | 1 |
4 review(s) available for amsacrine and acridines
| Article | Year |
|---|---|
Mechanisms of action of DNA intercalating acridine-based drugs: how important are contributions from electron transfer and oxidative stress?
Topics: Acridines; Amsacrine; Antineoplastic Agents; DNA; Electron Transport; Humans; Intercalating Agents; Neoplasms; Oxidative Stress | 2003 |
Synthesis and structure-activity studies of peptide-acridine/acridone conjugates.
Topics: Acridines; Acridones; Amsacrine; Animals; Antineoplastic Agents; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oligopeptides; Structure-Activity Relationship | 2007 |
Synthesis, structure-activity relationship and biological activity of acridine derivatives as potent MDR-reversing agents.
Topics: Acridines; Amsacrine; Antineoplastic Agents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; K562 Cells; Structure-Activity Relationship | 2013 |
Acridine derivatives as inhibitors/poisons of topoisomerase II.
Topics: Acridines; Amsacrine; Antineoplastic Agents; DNA Topoisomerases, Type II; Poisons | 2022 |
39 other study(ies) available for amsacrine and acridines
| Article | Year |
|---|---|
Novel acridine-triazenes as prototype combilexins: synthesis, DNA binding, and biological activity.
Topics: Acridines; Animals; Antineoplastic Agents; Base Sequence; Cattle; Diminazene; DNA; Drug Design; Humans; Models, Molecular; Molecular Sequence Data; Thymus Gland; Triazenes; Tumor Cells, Cultured | 1995 |
Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα.
Topics: Acridines; Amsacrine; Antigens, Neoplasm; Antineoplastic Agents; DNA; DNA Cleavage; DNA Topoisomerases, Type II; DNA-Binding Proteins; Enzyme Activation; Humans; Intercalating Agents; Topoisomerase II Inhibitors | 2017 |
Photo-enhancement of the mutagenicity of 9-anilinoacridine derivatives related to the antitumour agent amsacrine.
Topics: Acridines; Aminoacridines; Amsacrine; Antineoplastic Agents; Dose-Response Relationship, Drug; Frameshift Mutation; Light; Mutagenicity Tests; Mutagens; Oxidation-Reduction; Proflavine; Salmonella typhimurium | 1992 |
Comparison of the blood-brain barrier and liver penetration of acridine antitumor drugs.
Topics: Acridines; Aminoacridines; Amsacrine; Anesthesia; Animals; Antineoplastic Agents; Barbiturates; Blood-Brain Barrier; Brain; Butanols; Carotid Arteries; Diazepam; Injections, Intra-Arterial; Injections, Intravenous; Liver; Mice; Portal Vein | 1992 |
Unusual dynamics of killing of cultured Lewis lung cells by the DNA-intercalating antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
Topics: Acridines; Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cell Death; Cell Survival; DNA, Neoplasm; Intercalating Agents; Kinetics; Lung Neoplasms; Time Factors; Tumor Cells, Cultured | 1992 |
Potentiation by phenylbisbenzimidazoles of cytotoxicity of anticancer drugs directed against topoisomerase II.
Topics: Acridines; Amsacrine; Animals; Antineoplastic Agents; Benzimidazoles; Bisbenzimidazole; Colonic Neoplasms; Doxorubicin; Drug Synergism; Etoposide; Fluorescent Dyes; Leukemia L1210; Lung Neoplasms; Melanoma; Mice; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1990 |
Interactions of anilinoacridines with nucleic acids: effects of substituent modifications on DNA-binding properties.
Topics: Acridines; Amsacrine; Animals; Cattle; DNA; Osmolar Concentration; Thermodynamics | 1991 |
Genetic toxicology of tricyclic carboxamides, a new class of DNA binding antitumour agent.
Topics: Acridines; Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cells, Cultured; Cricetinae; Cricetulus; DNA; Fibroblasts; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagenicity Tests; Mutagens; Phenazines; Salmonella typhimurium | 1990 |
Selectivity of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide towards Lewis lung carcinoma and human tumour cell lines in vitro.
Topics: Acridines; Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Humans; Lung Neoplasms; Mice; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
Acridine derivatives. III. Preparation and antitumor activity of the novel acridinyl-substituted uracils.
Topics: Acridines; Amsacrine; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Mice; Mice, Inbred DBA; Structure-Activity Relationship; Uracil | 1989 |
Cell line selectivity and DNA breakage properties of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide: role of DNA topoisomerase II.
Topics: Acridines; Aminacrine; Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cell Survival; DNA Damage; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Neoplasm Proteins; Quinacrine; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1988 |
DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II.
Topics: Acridines; Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cattle; DNA; DNA Repair; DNA Topoisomerases, Type II; Mice; Nalidixic Acid; Phosphorus Radioisotopes; Tyrosine | 1986 |
Verapamil modulates mutagenicity of antitumour acridines in bacteria and yeast.
Topics: Acridines; Amsacrine; Animals; Cell Line; Doxorubicin; Drug Resistance; Leukemia, Experimental; Mice; Mutagenicity Tests; Saccharomyces cerevisiae; Salmonella typhimurium; Verapamil | 1986 |
Electron donor properties of the antitumour drug amsacrine as studied by fluorescence quenching of DNA-bound ethidium.
Topics: Acridines; Amsacrine; Depression, Chemical; DNA; Electrochemistry; Electrons; Ethidium; Fluorescence; Fluorometry; Poly dA-dT | 1987 |
Potential antitumor agents. 47. 3'-Methylamino analogues of amsacrine with in vivo solid tumor activity.
Topics: Acridines; Aminoacridines; Amsacrine; Animals; Cell Line; Chemical Phenomena; Chemistry; Colonic Neoplasms; DNA; Humans; Leukemia L1210; Leukemia P388; Mice; Solubility; Structure-Activity Relationship | 1986 |
Interaction of the antitumor drug 4'-(9-acridinylamino)methanesulfon-m-anisidide and related acridines with nucleic acids.
Topics: Acridines; Aminoacridines; Amsacrine; Binding Sites; Binding, Competitive; Chemical Phenomena; Chemistry; DNA; Kinetics; Ligands; Nucleic Acid Denaturation; RNA; Spectrophotometry | 1981 |
Frameshift mutagenesis by 9-aminoacridine, ICR191, AMSA and related experimental antitumour acridines in recA+ and recA1 strains of Salmonella typhimurium.
Topics: Acridines; Aminacrine; Aminoacridines; Amsacrine; Antineoplastic Agents; DNA Repair; Mutagenicity Tests; Mutagens; Nitrogen Mustard Compounds; Salmonella typhimurium; Structure-Activity Relationship | 1983 |
Inhibition of T4 bacteriophage yield by 9-anilinoacridines; comparison with in vivo antitumour activity.
Topics: Acridines; Aminoacridines; Amsacrine; Animals; DNA, Viral; Dose-Response Relationship, Drug; Leukemia L1210; Mice; Structure-Activity Relationship; T-Phages | 1980 |
[Topoisomerase II mediated DNA strand cleavage and antitumor activities against murine leukemia P388 of novel acridines].
Topics: Acridines; Amsacrine; Animals; DNA Damage; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Leukemia P388; Male; Mice; Mice, Inbred Strains | 1994 |
Topoisomerase II mediated DNA lesions induced by acridine-4-carboxamide and 2-(4-pyridyl)quinoline-8-carboxamide.
Topics: Acridines; Amsacrine; Animals; Antineoplastic Agents; DNA Damage; DNA Topoisomerases, Type II; Intercalating Agents; Mice; Quinolines; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1994 |
Cytokinetic differences in the action of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide as compared with that of amsacrine and doxorubicin.
Topics: Acridines; Adenocarcinoma; Amsacrine; Antineoplastic Agents; Cell Cycle; DNA, Neoplasm; Doxorubicin; Flow Cytometry; Lung Neoplasms; Tumor Cells, Cultured | 1993 |
A comparison of the effects of aphidicolin and other inhibitors on topoisomerase II-directed cytotoxic drugs.
Topics: Acridines; Amsacrine; Animals; Antineoplastic Agents; Aphidicolin; Cell Survival; DNA Replication; Doxorubicin; Mice; Thymidine; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Uridine | 1993 |
Inhibition by SKF-525A of the aldehyde oxidase-mediated metabolism of the experimental antitumour agent acridine carboxamide.
Topics: Acridines; Acridones; Aldehyde Oxidase; Aldehyde Oxidoreductases; Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cimetidine; Cytosol; Kinetics; Liver; Male; Methimazole; Metyrapone; Microsomes, Liver; NAD; Proadifen; Rats; Rats, Wistar | 1993 |
From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide): selectivity for topoisomerases I and II among acridine derivatives.
Topics: Acridines; Amsacrine; Antineoplastic Agents; DNA; DNA Damage; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Leukemia; Tumor Cells, Cultured | 1996 |
The potential of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide to circumvent three multidrug-resistance phenotypes in vitro.
Topics: Acridines; Amsacrine; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Line; Cell Survival; Daunorubicin; Drug Resistance, Multiple; HL-60 Cells; Humans; Idarubicin; Leukemia; Paclitaxel; Phenotype; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Verapamil | 1997 |
Mechanism of cytotoxicity of N-[2-(dimethylamino)ethyl] acridine-4-carboxamide and of its 7-chloro derivative: the roles of topoisomerases I and II.
Topics: Acridines; Amsacrine; Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Survival; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Enzyme Inhibitors; Humans; Kinetics; Lung Neoplasms; Mice; Models, Chemical; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1999 |
A molecular modeling study of B-DNA-intercalation complexes with amsacrine and related 9-anilino-acridines.
Topics: Acridines; Amsacrine; Aniline Compounds; Antineoplastic Agents; DNA; Hydrogen Bonding; Intercalating Agents; Ligands; Models, Molecular; Molecular Conformation; Nucleic Acid Conformation; Oligonucleotides | 1999 |
Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives.
Topics: Acridines; Amsacrine; Antineoplastic Agents; DNA; DNA Footprinting; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Intercalating Agents; Picolinic Acids; Pyridones; Tumor Cells, Cultured | 1998 |
Inhibition of DNA topoisomerase II catalytic activity by the antiviral agents 7-chloro-1,3-dihydroxyacridone and 1,3,7-trihydroxyacridone.
Topics: Acridines; Amsacrine; Antineoplastic Agents; Antiviral Agents; Catalysis; DNA; Enzyme Inhibitors; Etoposide; Humans; Plasmids; Topoisomerase II Inhibitors | 1999 |
Crystal structure of the topoisomerase II poison 9-amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide bound to the DNA hexanucleotide d(CGTACG)2.
Topics: Acridines; Amsacrine; Antineoplastic Agents; Binding Sites; Crystallization; Crystallography, X-Ray; Deoxyribonucleotides; DNA; Enzyme Inhibitors; Intercalating Agents; Kinetics; Ligands; Macromolecular Substances; Models, Molecular; Molecular Conformation; Nucleic Acid Conformation; Structure-Activity Relationship; Topoisomerase II Inhibitors; Water | 1999 |
Carbamate analogues of amsacrine active against non-cycling cells: relative activity against topoisomerases IIalpha and beta.
Topics: Acridines; Amsacrine; Animals; Antigens, Neoplasm; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Cycle; CHO Cells; Cricetinae; DNA Topoisomerases, Type II; DNA-Binding Proteins; Etoposide; Humans; Isoenzymes; Mice; Poly-ADP-Ribose Binding Proteins; Saccharomyces cerevisiae; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1999 |
Murine transgenic cells lacking DNA topoisomerase IIbeta are resistant to acridines and mitoxantrone: analysis of cytotoxicity and cleavable complex formation.
Topics: Acridines; Amsacrine; Animals; Antigens, Neoplasm; Antineoplastic Agents; Cell Survival; Cells, Cultured; DNA Topoisomerases, Type II; DNA-Binding Proteins; Etoposide; Isoenzymes; Mice; Mice, Transgenic; Mitoxantrone; Topoisomerase II Inhibitors | 1999 |
Solid-phase synthesis of acridine-peptide conjugates and their analysis by tandem mass spectrometry.
Topics: Acridines; Amsacrine; Indicators and Reagents; Models, Molecular; Molecular Structure; Peptides; Spectrometry, Mass, Secondary Ion | 2000 |
Synthesis and antiproliferative activity of some variously substituted acridine and azacridine derivatives.
Topics: Acridines; Amsacrine; Animals; Antineoplastic Agents; Aza Compounds; Carcinoma, Ehrlich Tumor; Cell Division; DNA; DNA Damage; Drug Screening Assays, Antitumor; Enzyme Inhibitors; HeLa Cells; HL-60 Cells; Humans; Inhibitory Concentration 50; Mice; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2000 |
Synthesis and antiinflammatory evaluation of 9-anilinoacridine and 9-phenoxyacridine derivatives.
Topics: Acridines; Amsacrine; Aniline Compounds; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Degranulation; Cells, Cultured; Drug Screening Assays, Antitumor; Humans; Macrophages; Mast Cells; Mice; Neutrophils; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest.
Topics: Acridines; Amsacrine; Animals; Apoptosis; CDC2 Protein Kinase; Cell Division; Cyclin B; DNA Damage; Fibroblasts; G2 Phase; Mice; Mice, Knockout; Poly(ADP-ribose) Polymerases; Topoisomerase II Inhibitors; Triazoles; Tumor Suppressor Protein p53 | 2004 |
mAMSA resistant human topoisomerase IIbeta mutation G465D has reduced ATP hydrolysis activity.
Topics: Acridines; Adenosine Triphosphate; Amsacrine; Antineoplastic Agents; Directed Molecular Evolution; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance; Enzyme Inhibitors; Fluorescence Polarization; Humans; Hydrolysis; Magnesium Chloride; Point Mutation | 2006 |
Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage.
Topics: Acridines; Amsacrine; Aniline Mustard; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Molecular Structure; Rats; Stereoisomerism; Urea; Xenograft Model Antitumor Assays | 2008 |
Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives.
Topics: Acridines; Alkylation; Amsacrine; Animals; Antineoplastic Agents; Biosensing Techniques; Cell Line, Tumor; Cell Survival; DNA; Drug Screening Assays, Antitumor; Electrochemical Techniques; Humans; Molecular Structure; Thiazolidines | 2012 |