ampicillin-sodium and canthin-6-one

ampicillin-sodium has been researched along with canthin-6-one* in 1 studies

Other Studies

1 other study(ies) available for ampicillin-sodium and canthin-6-one

Article	Year
Synthesis, in vitro antibacterial activities of a series of 3-N-substituted canthin-6-ones. Bioorganic & medicinal chemistry letters, 2016, Jan-15, Volume: 26, Issue:2 An improved synthetic route of canthin-6-one was accomplished. To further enhance the antibacterial potency and improve water solubility, a series of 3-N-alkylated and 3-N-benzylated canthin-6-ones were designed and synthesized, and their in vitro antibacterial activities were evaluated. A clear structure-activity relationship with peak minimal inhibitory concentration (MIC) values of 0.98 (μg·mL(-)(1)) was investigated. Particularly, compounds 6i-r and 6t were found to be the most potent compounds with minimal inhibitory concentration (MIC) values lower than 1.95 (μg·mL(-)(1)) against Staphylococcus aureus. Topics: Alkylation; Anti-Bacterial Agents; Carbolines; Humans; Indole Alkaloids; Microbial Sensitivity Tests; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship	2016

Article

Year

Synthesis, in vitro antibacterial activities of a series of 3-N-substituted canthin-6-ones.

Bioorganic & medicinal chemistry letters, 2016, Jan-15, Volume: 26, Issue:2

An improved synthetic route of canthin-6-one was accomplished. To further enhance the antibacterial potency and improve water solubility, a series of 3-N-alkylated and 3-N-benzylated canthin-6-ones were designed and synthesized, and their in vitro antibacterial activities were evaluated. A clear structure-activity relationship with peak minimal inhibitory concentration (MIC) values of 0.98 (μg·mL(-)(1)) was investigated. Particularly, compounds 6i-r and 6t were found to be the most potent compounds with minimal inhibitory concentration (MIC) values lower than 1.95 (μg·mL(-)(1)) against Staphylococcus aureus.

Topics: Alkylation; Anti-Bacterial Agents; Carbolines; Humans; Indole Alkaloids; Microbial Sensitivity Tests; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship

2016