amphotericin-b and salicylamide

amphotericin-b has been researched along with salicylamide* in 1 studies

Other Studies

1 other study(ies) available for amphotericin-b and salicylamide

Article	Year
New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities. Bioorganic & medicinal chemistry letters, 2011, Aug-01, Volume: 21, Issue:15 Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, 14 new 3-amino-1,4-di-N-oxide quinoxaline-2-carbonitrile derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum Colombian FCR-3 strain and Leishmania amazonensis strain MHOM/BR/76/LTB-012A. Further computational studies were carried out in order to analyze graphic SAR and ADME properties. The results obtained indicate that compounds with one halogenous group substituted in position 6 and 7 provide an efficient approach for further development of antimalarial and antileishmanial agents. In addition, interesting ADME properties were found. Topics: Animals; Antimalarials; Leishmania mexicana; Macrophages; Mice; Plasmodium falciparum; Quinoxalines; Salicylamides; Structure-Activity Relationship; Sulfonamides; Trypanocidal Agents	2011

Article

Year

New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities.

Bioorganic & medicinal chemistry letters, 2011, Aug-01, Volume: 21, Issue:15

Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, 14 new 3-amino-1,4-di-N-oxide quinoxaline-2-carbonitrile derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum Colombian FCR-3 strain and Leishmania amazonensis strain MHOM/BR/76/LTB-012A. Further computational studies were carried out in order to analyze graphic SAR and ADME properties. The results obtained indicate that compounds with one halogenous group substituted in position 6 and 7 provide an efficient approach for further development of antimalarial and antileishmanial agents. In addition, interesting ADME properties were found.

Topics: Animals; Antimalarials; Leishmania mexicana; Macrophages; Mice; Plasmodium falciparum; Quinoxalines; Salicylamides; Structure-Activity Relationship; Sulfonamides; Trypanocidal Agents

2011