Page last updated: 2024-08-17

amodiaquine hydrochloride and chloroquine

amodiaquine hydrochloride has been researched along with chloroquine in 45 studies

Research

Studies (45)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (6.67)	18.2507
2000's	22 (48.89)	29.6817
2010's	20 (44.44)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Harrison, AC; Hawley, SR; O'Neill, PM; Park, BK; Storr, RC; Ward, SA	1
Bray, PG; Hawley, SR; O'Neill, PM; Park, BK; Storr, RC; Ward, SA; Willock, DJ	1
O'Neill, PM; Park, BK; Raynes, KJ; Stocks, PA; Ward, SA	1
Debreu-Fontaine, MA; Delarue, S; Girault, S; Grellier, P; Labaeïd, M; Maes, L; Sergheraert, C	1
Bickley, JF; Bray, PG; Hindley, S; Hughes, RH; Maggs, JL; Mukhtar, A; O'Neil, IA; O'Neill, PM; Park, BK; Randle, LE; Stocks, PA; Storr, RC; Ward, SA; Winstanley, PA	1
Altarelli, M; Basilico, N; Butini, S; Campiani, G; Fattorusso, C; Fattorusso, E; Gemma, S; Kukreja, G; Persico, M; Romano, MP; Savini, L; Taramelli, D; Yardley, V	1
Harada, S; Huy, NT; Kamei, K; Maeda, A; Oida, T; Trang, DT; Uyen, DT	1
Adagu, IS; Fivelman, QL; Warhurst, DC	1
Delarue-Cochin, S; Grellier, P; Maes, L; Melnyk, P; Mouray, E; Paunescu, E; Sergheraert, C	1
Anstey, NM; Brockman, A; Chalfein, F; Cheng, Q; Kenangalem, E; Piera, K; Prasetyorini, B; Prayoga, P; Price, RN; Russell, B; Sugiarto, P; Suwanarusk, R; Tjitra, E	1
Delarue-Cochin, S; Grellier, P; Maes, L; Melnyk, P; Mouray, E; Sergheraert, C	1
Becker, K; Davioud-Charvet, E; Friebolin, W; Furrer, J; Jannack, B; Lanzer, M; Oeser, T; Sanchez, CP; Wenzel, N; Yardley, V	1
Fitos, I; Mády, G; Visy, J; Zsila, F	1
Egan, TJ; Hoppe, HC; Joiner, KA; Roberts, L	1
Amewu, R; Bongard, E; Charnaud, S; Davies, J; Ellis, GL; Gargallo, D; Gibbons, P; Hall, C; Jesús, M; Lozanom, S; O'Neill, PM; Rimmer, K; Sabbani, S; Shone, A; Stanford, D; Stocks, PA; Vivas, L; Ward, SA	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Adrián, F; Anderson, P; Brinker, A; Caldwell, JS; Chatterjee, A; Gray, NS; Henson, K; Janes, J; Kato, N; Kuhen, K; Matzen, JT; McNamara, C; Nagle, A; Nam, TG; Plouffe, D; Schultz, PG; Trager, R; Winzeler, EA; Yan, SF; Zhou, Y	1
Anstey, NM; Chalfien, F; Hasugian, AR; Kenangalem, E; Marfurt, J; Penttinen, PM; Piera, KA; Price, RN; Purba, HL; Ratcliff, A; Russell, B; Siswantoro, H; Tjitra, E; Wuwung, RM	1
Bambal, RB; Bates, M; Berry, N; Biagini, GA; Bonar-Law, R; Bray, PG; Brigandi, RA; Davis, CB; Gargallo, DV; Gibbons, P; Gomez-delas-Heras, FM; Gresham, SL; Hart, TK; Hindley, S; Lawrence, RM; Maggs, JL; Mukhtar, A; O'Neill, PM; Park, BK; Roberts, P; Shone, AE; Stocks, PA; Ward, SA; Winstanley, PA	1
Asadollahy, E; Bambal, RB; Bates, M; Berry, N; Biagini, G; Bray, PG; Brigandi, RA; Davies, J; Davis, CB; Gargallo, DV; Gomez-de-Las-Heras, FM; Gresham, SL; Hall, C; Hindley, S; Lander, H; Maggs, JL; Nixon, G; O'Neill, PM; Parapini, S; Park, BK; Rimmer, K; Roberts, P; Shone, AE; Stanford, D; Stocks, PA; Taramelli, D; Vivas, L; Ward, SA; Winstanley, PA	1
Baniecki, ML; Clardy, J; Cortese, JF; Mazitschek, R; Rush, MA; Wiegand, R; Wirth, DF	1
Gómez-Barrio, A; Kouznetsov, VV	1
Masseno, V; Muriithi, S; Nzila, A	1
Bertinaria, M; Croft, SL; Crosetti, M; Fruttero, R; Gasco, A; Guglielmo, S; Rolando, B; Yardley, V	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Biot, C; Brun, R; Chavain, N; Davioud-Charvet, E; Friebolin, W; Herold-Mende, C; Lanzer, M; Maes, L; Pradines, B; Tóth, K; Wang, Y; Wenzel, NI; Yardley, V	1
Glen, RC; Lowe, R; Mitchell, JB	1
Anstey, NM; Chalfein, F; Kenangalem, E; Marfurt, J; Piera, KA; Price, RN; Russell, B; Tjitra, E	1
Anstey, NM; Chalfein, F; Ebsworth, EP; Kenangalem, E; Marfurt, J; Piera, KA; Prasetyorini, B; Price, RN; Ratcliff, A; Russell, B; Siswantoro, H; Tjitra, E; Wuwung, M	1
Andrews, KT; Anstey, NM; Chalfein, F; Fairlie, DP; Kenangalem, E; Marfurt, J; Piera, KA; Prayoga, P; Price, RN; Tjitra, E; Wabiser, F	1
Aragno, C; Bertinaria, M; Carvalho, LJ; Fruttero, R; Gasco, A; Giorgis, M; Guglielmo, S; Martins, YC; Parapini, S; Rolando, B; Taramelli, D	1
Chandrashekar, G; Chatterji, D; Meng, L; Robinson, K; Zhu, S	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chibale, K; Gut, J; Masimirembwa, CM; Ongarora, DS; Rosenthal, PJ	1
Alpert, TD; Jez, JM; Lee, SG	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Bartolommei, G; Basilico, N; Brindisi, M; Brogi, S; Butini, S; Camodeca, C; Campiani, G; Fiorini, I; Gabellieri, E; Gemma, S; Gualdani, R; Habluetzel, A; Kukreja, G; Kunjir, S; Lamponi, S; Lucantoni, L; Martin, RE; Moncelli, MR; Novellino, E; Savini, L; Summers, RL; Tadini-Buoninsegni, F; Taramelli, D; Valoti, M	1
de Dios, A; Gorka, AP; Roepe, PD	1
Biamonte, MA; Le Roch, KG; Wanner, J	1
Barteau, S; Chibale, K; Gut, J; Heudi, O; Kameni-Tcheudji, J; Mugumbate, GC; Njoroge, M; Rosenthal, PJ; Streckfuss, J; Tukulula, M	1
Avery, VM; Sykes, ML	1
Egan, TJ; Hunter, R; Joshi, MC; Smith, PJ; Taylor, D; Wicht, KJ	1
Anh Ngoc, T; Egan, TJ; Imai, K; Inokuchi, T; Kaiser, M; Kiguchi, R; Wang, MQ; Wang, N; Wicht, KJ	1

Reviews

4 review(s) available for amodiaquine hydrochloride and chloroquine

Article	Year
Recent developments in the design and synthesis of hybrid molecules based on aminoquinoline ring and their antiplasmodial evaluation. European journal of medicinal chemistry, 2009, Volume: 44, Issue:8 Topics: Aminoquinolines; Animals; Antimalarials; Drug Design; Humans; Plasmodium	2009
Quinoline drug-heme interactions and implications for antimalarial cytostatic versus cytocidal activities. Journal of medicinal chemistry, 2013, Jul-11, Volume: 56, Issue:13 Topics: Antimalarials; Crystallization; Drug Resistance; Heme; Hemeproteins; Humans; Malaria, Falciparum; Molecular Structure; Plasmodium falciparum; Quinolines	2013
Recent advances in malaria drug discovery. Bioorganic & medicinal chemistry letters, 2013, May-15, Volume: 23, Issue:10 Topics: Animals; Antimalarials; Drug Discovery; Humans; Liver; Liver Transplantation; Malaria; Molecular Structure	2013
Approaches to protozoan drug discovery: phenotypic screening. Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20 Topics: Drug Discovery; Humans; Molecular Structure; Neglected Diseases; Phenotype; Plasmodium falciparum; Protozoan Infections; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi	2013

Other Studies

41 other study(ies) available for amodiaquine hydrochloride and chloroquine

Article	Year
The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine. Journal of medicinal chemistry, 1994, Apr-29, Volume: 37, Issue:9 Topics: Amodiaquine; Animals; Chloroquine; Fluorine; Molecular Structure; Oxidation-Reduction; Plasmodium falciparum; Structure-Activity Relationship	1994
Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues. Journal of medicinal chemistry, 1997, Feb-14, Volume: 40, Issue:4 Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Heme; Humans; Models, Molecular; Plasmodium falciparum	1997
New 4-aminoquinoline Mannich base antimalarials. 1. Effect of an alkyl substituent in the 5'-position of the 4'-hydroxyanilino side chain. Journal of medicinal chemistry, 1999, Jul-29, Volume: 42, Issue:15 Topics: Aniline Compounds; Animals; Antimalarials; Inhibitory Concentration 50; Malaria; Male; Mannich Bases; Mice; Plasmodium berghei; Plasmodium falciparum; Quinolines; Structure-Activity Relationship	1999
Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines. Journal of medicinal chemistry, 2001, Aug-16, Volume: 44, Issue:17 Topics: Aniline Compounds; Animals; Antimalarials; Cells, Cultured; Drug Resistance; Female; Humans; Macrophages, Peritoneal; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Quinolines; Structure-Activity Relationship	2001
Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials. Journal of medicinal chemistry, 2003, Nov-06, Volume: 46, Issue:23 Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Crystallography, X-Ray; Malaria; Male; Plasmodium falciparum; Plasmodium yoelii; Rats; Rats, Wistar; Structure-Activity Relationship	2003
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains. Bioorganic & medicinal chemistry letters, 2006, Oct-15, Volume: 16, Issue:20 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Hydrazones; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Stereoisomerism; Structure-Activity Relationship	2006
Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:1 Topics: Animals; Antimalarials; Colorimetry; Crystallization; Drug Evaluation, Preclinical; Heme; Hemeproteins; Plasmodium falciparum; Polysorbates; Reproducibility of Results	2007
Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Antagonism; Drug Combinations; Drug Interactions; Drug Resistance; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Sesquiterpenes; Tritium	2007
Synthesis and antimalarial activity of new analogues of amodiaquine. European journal of medicinal chemistry, 2008, Volume: 43, Issue:2 Topics: Amodiaquine; Animals; Antimalarials; Cell Line; Chromatography, High Pressure Liquid; Female; Humans; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Mice; Plasmodium berghei	2008
Determinants of in vitro drug susceptibility testing of Plasmodium vivax. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:3 Topics: Animals; Antimalarials; Chloroquine; Humans; Inhibitory Concentration 50; Life Cycle Stages; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodium vivax; Schizonts; Time Factors	2008
Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline. European journal of medicinal chemistry, 2008, Volume: 43, Issue:10 Topics: Amides; Animals; Antimalarials; Carbamates; Cell Line; Female; Humans; Malaria; Mice; Plasmodium falciparum; Quinolines; Structure-Activity Relationship	2008
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5 Topics: Animals; Antimalarials; Biological Transport; Cell Line, Tumor; Chloroquine; Drug Resistance; Drug Therapy, Combination; Glutathione Reductase; Humans; In Vitro Techniques; Malaria; Mice; Mice, Inbred BALB C; Naphthalenes; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship	2008
Selective plasma protein binding of antimalarial drugs to alpha1-acid glycoprotein. Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7 Topics: Antimalarials; Binding Sites; Chromatography, Affinity; Circular Dichroism; Humans; Molecular Structure; Orosomucoid; Protein Binding; Serum Albumin; Spectrophotometry; Stereoisomerism; Structure-Activity Relationship	2008
Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5 Topics: Amodiaquine; Animals; Antimalarials; Blotting, Western; Chloroquine; Endocytosis; Erythrocytes; Hemoglobins; Humans; Mefloquine; Peroxidase; Phenanthrenes; Plasmodium falciparum; Protein Binding; Protozoan Proteins; Quinolines	2008
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles. Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7 Topics: Animals; Antimalarials; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Stability; Humans; Male; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Rats; Salmonella typhimurium; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Tetraoxanes	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proceedings of the National Academy of Sciences of the United States of America, 2008, Jul-01, Volume: 105, Issue:26 Topics: Animals; Antimalarials; Cluster Analysis; Computational Biology; Drug Evaluation, Preclinical; Drug Resistance; Folic Acid Antagonists; Malaria; Models, Molecular; Parasites; Plasmodium falciparum; Reproducibility of Results; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase	2008
In vivo and in vitro efficacy of amodiaquine monotherapy for treatment of infection by chloroquine-resistant Plasmodium vivax. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3 Topics: Adolescent; Age Distribution; Amodiaquine; Animals; Antimalarials; Chloroquine; Confidence Intervals; Drug Resistance; Drug Tolerance; Female; Follow-Up Studies; Humans; Inhibitory Concentration 50; Male; Outpatients; Parasitemia; Plasmodium vivax; Prospective Studies; Recurrence; Rural Health; Time Factors; Treatment Failure; Treatment Outcome	2009
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5 Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Benzylamines; Cytochrome P-450 Enzyme Inhibitors; Dogs; Drug Evaluation, Preclinical; Drug Resistance; Female; Haplorhini; Heme; Humans; Malaria; Mice; Models, Molecular; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Rats; Structure-Activity Relationship	2009
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine. Journal of medicinal chemistry, 2009, Apr-09, Volume: 52, Issue:7 Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Cell Survival; Chloroquine; Dogs; Drug Resistance; Female; Haplorhini; Hepatocytes; Humans; In Vitro Techniques; Malaria; Male; Mice; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Rats; Rats, Wistar; Structure-Activity Relationship	2009
Colorimetric high-throughput screen for detection of heme crystallization inhibitors. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:6 Topics: Animals; Antimalarials; Colorimetry; Crystallization; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Heme; Hemeproteins; Plasmodium falciparum	2009
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7 Topics: Adjuvants, Pharmaceutic; Animals; Antimalarials; Parasitic Sensitivity Tests; Plasmodium falciparum; Probenecid; Verapamil	2009
A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity. European journal of medicinal chemistry, 2009, Volume: 44, Issue:12 Topics: Amodiaquine; Animals; Anthelmintics; Antiprotozoal Agents; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Leishmania donovani; Macrophages; Mice; Molecular Structure; Plasmodium falciparum	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA. Journal of medicinal chemistry, 2010, Apr-22, Volume: 53, Issue:8 Topics: Aminoquinolines; Antimalarials; Antineoplastic Agents; Cell Line, Tumor; DNA; Drug Resistance; Drug Screening Assays, Antitumor; Hemeproteins; Humans; Mannich Bases; Plasmodium falciparum; Structure-Activity Relationship	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Inhibitory Concentration 50; Naphthyridines; Plasmodium falciparum; Plasmodium vivax	2010
In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:1 Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans; Indonesia; Malaria; Male; Middle Aged; Plasmodium malariae; Plasmodium ovale; Treatment Outcome; Young Adult	2011
Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:3 Topics: Drug Resistance, Multiple, Bacterial; Histone Deacetylase Inhibitors; Hydroxamic Acids; Microbial Sensitivity Tests; Plasmodium falciparum; Plasmodium vivax; Vorinostat	2011
Amodiaquine analogues containing NO-donor substructures: synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria. European journal of medicinal chemistry, 2011, Volume: 46, Issue:5 Topics: Amodiaquine; Animals; Antiprotozoal Agents; Aorta, Thoracic; Chemistry, Physical; Malaria, Cerebral; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Nitric Oxide Donors; Oxadiazoles; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship	2011
Febrifugine analogue compounds: synthesis and antimalarial evaluation. Bioorganic & medicinal chemistry, 2012, Jan-15, Volume: 20, Issue:2 Topics: Animals; Antimalarials; Aotus trivirgatus; Drug Evaluation, Preclinical; Malaria; Piperidines; Plasmodium falciparum; Quinazolines	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation. Bioorganic & medicinal chemistry letters, 2012, Aug-01, Volume: 22, Issue:15 Topics: Amodiaquine; Animals; Antimalarials; Benzimidazoles; Benzothiazoles; Benzoxazoles; Cell Line; Drug Resistance, Microbial; Heterocyclic Compounds; Plasmodium falciparum; Pyridines; Rats; Structure-Activity Relationship	2012
Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine. Bioorganic & medicinal chemistry letters, 2012, Aug-01, Volume: 22, Issue:15 Topics: Aminoquinolines; Amodiaquine; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Methyltransferases; Plasmodium falciparum; Protein Structure, Tertiary	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents. Journal of medicinal chemistry, 2012, Dec-13, Volume: 55, Issue:23 Topics: Animals; Antimalarials; Benzoxazines; Cell Line; Humans; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Mimicry; Quinazolines; Spectrometry, Mass, Electrospray Ionization	2012
Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents. Bioorganic & medicinal chemistry, 2013, Sep-01, Volume: 21, Issue:17 Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Binding Sites; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Resistance; Half-Life; Humans; Microsomes, Liver; Molecular Docking Simulation; Plasmodium falciparum; Protein Structure, Tertiary; Rats; Structure-Activity Relationship; Tetrazoles	2013
In vitro antimalarial activity, β-haematin inhibition and structure-activity relationships in a series of quinoline triazoles. European journal of medicinal chemistry, 2013, Volume: 69 Topics: Antimalarials; Dose-Response Relationship, Drug; Hemeproteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Structure-Activity Relationship; Triazoles	2013
Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo[3,2-c]quinolines with various substituents at C2, C6, and N11. Bioorganic & medicinal chemistry, 2014, May-01, Volume: 22, Issue:9 Topics: Animals; Antimalarials; Cell Line; Cell Survival; Hemin; Humans; Indole Alkaloids; Indoles; Mice; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Quinolines; Rats; Structure-Activity Relationship	2014