Compounds > amodiaquine

amodiaquine and desethylamodiaquine

amodiaquine has been researched along with desethylamodiaquine in 79 studies

Research

Studies (79)

TimeframeStudies, this research(%)All Research%
pre-19908 (10.13)18.7374
1990's9 (11.39)18.2507
2000's25 (31.65)29.6817
2010's30 (37.97)24.3611
2020's7 (8.86)2.80

Authors

AuthorsStudies
Basco, LK; Le Bras, J2
el Benna, J; Labro, MT1
Basco, LK2
Bryskier, A; Chrétien, P; Lafont, O; Ménager, S1
Breckenridge, AM; Coleman, JW; Maggs, JL; Park, BK; Winstanley, PA1
Breckenridge, AM; Edwards, G; Kofi-Ekue, JM; Orme, ML; Salako, LA; Simooya, O; Walker, O; Winstanley, PA1
Boudreau, EF; Childs, GE; Davidson, DE; Milhous, WK; Pang, L; Pooyindee, N; Wimonwattratee, T1
Drouville, C; Guigon, D; Le Bras, J; Porte, J; Simon, F; Verdier, F1
Biaud, JM; Calmel, MB; Clausse, JL; Deloron, P; Hatin, I; Le Bras, J; Marchais, H; Porte, J; Ramanamirija, JA; Simon, F1
Coulanges, P; Le Bras, J; Marchais, H; Ramanamirija, JA1
Breckenridge, AM; Edwards, G; Orme, ML; Winstanley, PA1
Breckenridge, A; Edwards, G; Orme, M; Winstanley, P1
Blayo, MC; Faurisson, F; Pussard, E; Verdier, F1
Idowu, OR; Salako, LA1
Jewell, H; Maggs, JL; O'Neill, PM; Park, BK; Tingle, MD1
Baba, H; Campistron, G; Chretien, P; Coulais, Y; Laurent, F; Magnaval, JF; Peyron, F; Saivin, S; Sqalli, A; Tufenkji, AE1
Basco, LK; Keundjian, A; Ringwald, P; Same Ekobo, A1
Andersson, TB; Björkman, A; Li, XQ; Masimirembwa, CM; Ridderström, M1
Warhurst, DC1
Gitau, EN; Githiga, IM; Kokwaro, GO; Muchohi, SN; Ogutu, BR1
Aubouy, A; Bakary, M; Deloron, P; Keundjian, A; Le Bras, J; Mayombo, J1
Björkman, A; Gil, JP; Mariga, ST; Sisowath, C; Wernsdorfer, WH1
Björkman, A; Ferreira, PM; Gil, JP; Holmgren, G; Obonyo, CO; Veiga, MI1
D'Alessandro, U; Erhart, A; Karema, C; Mupfasoni, D; Rusanganwa, E; Rwagacondo, C; Tinto, H; Van Marck, E; Van Overmeir, C; Vandoren, W1
Bertilsson, L; Gustafsson, LL; Mahindi, M; Nordmark, A; Pihlsgård, M; Wennerholm, A1
Bell, DJ; Molyneux, ME; Nyirongo, SK; Ward, SA; Winstanley, PA1
Goldstein, JA; Kroetz, DL; Ouedraogo, JB; Parikh, S; Rosenthal, PJ1
Andrianantenaina, HB; Ariey, F; Domarle, O; Randrianarivelojosia, M; Rason, MA; Raveloson, A1
Ali, AS; Ashton, M; Bhattarai, A; Björkman, A; Hietala, SF; Hombhanje, FW; Kaneko, A; Msellem, M; Röshammar, D; Strömberg, J1
Beck, O; Gustafsson, LL; Mahindi, M; Ntale, M; Ogwal-Okeng, JW1
Chen, X; Dai, X; Deng, P; Zhong, D1
Björkman, A; Echeverry, DF; Gil, JP; Higuita, JC; Holmgren, G; Murillo, C; Osorio, L1
Dravid, PV; Frye, RF1
Stepniewska, K; White, NJ1
Arango, E; Cravo, P; Do Rosário, VE; Maestre, A; Restrepo-Pineda, E1
Amalvict, R; Baret, E; Briolant, S; Fontaine, A; Fraisse, L; Fusaï, T; Henry, M; Mosnier, J; Pradines, B; Rogier, C1
Adjei, GO; Alifrangis, M; Goka, BQ; Hoegberg, LC; Kristensen, K; Kurtzhals, JA; Rodrigues, OP1
Le Hesran, JY; Sakho, M; Sarrassat, S1
Lai, CS; Mansor, SM; Muniandy, A; Nair, NK; Navaratnam, V; Olliaro, PL1
Joloba, M; Kiggundu, M; Nawaz, F; Nsobya, SL; Rosenthal, PJ1
Carn, G; Jullien, V; Juma, E; Kiechel, JR; Obonyo, C; Ogutu, B1
Almeras, L; Amalvict, R; Baret, E; Briolant, S; Gil, M; Henry, M; Parquet, V; Pradines, B; Rogier, C; Wurtz, N1
Blair, S; Deharo, E; Pabón, A1
Fortin, A; Jansen, FH; Verbeeck, RK1
Adewoye, EO; Folarin, O; Gbotosho, GO; Happi, CT; Michael, OS; Okuboyejo, TM; Sijuade, AO; Sowunmi, A1
Assi, SB; Basco, LK; Bla, KB; Djaman, AJ; Koné, M; Mazabraud, A; Yavo, W1
Amalvict, R; Baret, E; Briolant, S; Charras, S; Feraud, M; Henry, M; Huyghues des Etages, E; Pascual, A; Pradines, B; Rogier, C1
Cammas, M; Hsi, P; Jullien, V; Lindegardh, N; McGready, R; Nosten, F; Phyo, AP; Rijken, MJ; Singhasivanon, P; Tarning, J; White, NJ; Win, AK1
Adjalley, SH; Eappen, AG; Eastman, RT; Ekland, EH; Fidock, DA; Hoffman, SL; Johnston, GL; Lee, MC; Li, T; Richman, A; Sim, BK1
Anvikar, AR; Bhatt, RM; Dash, AP; Ghosh, SK; Kumar, A; Mohanty, SS; Pillai, CR; Sharma, B; Sharma, SK; Valecha, N1
Bergstrand, M; Cammas, M; Chotsiri, P; Day, NP; Jullien, V; Lindegardh, N; McGready, R; Nosten, F; Rijken, MJ; Singhasivanon, P; Tarning, J; White, NJ1
Ismail, R; Muthiah, YD; Ong, CE; Sulaiman, SA; Tan, SC1
Ali, A; Björkman, A; Ferreira, PE; Fröberg, G; Gil, JP; Mårtensson, A1
Adjei, GO; Alifrangis, M; Goka, BQ; Hoegberg, LC; Kurtzhals, JA; Oduro-Boatey, C; Rodrigues, OP1
Cooksey, R; Dahlström, S; Fairhurst, RM; Flegg, JA; Guerin, PJ; Johnson, JD; Le Bras, J; Le Nagard, H; Lim, P; Ménard, D; Mentré, F; Murillo, C; Musset, L; Noedl, H; Nosten, F; Nsobya, SL; Pradines, B; Quashie, NB; Sibley, CH; Sinou, V; Sriprawat, K; Woodrow, CJ1
Aubouy, A; Dahlström, S; Deloron, P; Ezinmègnon, S; Faucher, JF; Houzé, P; Houzé, S; Kendjo, E; Le Bras, J; Maïga-Ascofaré, O; Massougbodji, A; Wakpo, A1
Baret, E; Bercion, R; Camara, C; Diatta, B; Diémé, Y; Fall, B; Fall, KB; Fall, M; Mbaye, PS; Nakoulima, A; Pascual, A; Pradines, B; Wade, B; Wurtz, N1
Albassam, AA; Frye, RF; Mohamed, ME1
Bigira, V; Bloome, J; Byaruhanga, O; Conrad, MD; Cooper, RA; Dorsey, G; Greenhouse, B; Gut, J; Havlir, DV; Kakuru, A; Kamya, MR; Kapisi, J; Kozak, B; LeClair, N; Legac, J; Nakazibwe, C; Nsobya, SL; Okiring, J; Rosenthal, PJ; Tumwebaze, P; Walakira, A1
Hirasawa, N; Hiratsuka, M; Maekawa, M; Mano, N; Oda, A; Saito, T; Tsukada, C1
Jangid, AG; Mistri, HN; Patel, KR; Rathod, DM; Sanyal, M; Shrivastav, PS1
Amalvict, R; Camara, C; Diatta, B; Diémé, Y; Fall, B; Fall, M; Madamet, M; Nakoulima, A; Pradines, B; Wade, B1
Craig, JC; Raheem, KS; Warhurst, DC1
Commandeur, JN; Vermeulen, NP; Zhang, Y1
Amalvict, R; Benoit, N; Briolant, S; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Kounta, MB; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA1
Amalvict, R; Bercion, R; Diatta, B; Diawara, S; Fall, B; Gueye, MW; Kounta, MB; Lo, G; Madamet, M; Nakoulima, A; Pradines, B; Wade, KA1
Commandeur, JNM; den Braver-Sewradj, SP; Vermeulen, NPE; Vos, JC; Zhang, Y1
Byaruhanga, O; Ceja, FG; Conrad, MD; Cooper, RA; Katairo, T; Nsobya, SL; Rasmussen, SA; Rosenthal, PJ; Tumwebaze, PK1
Anh, CX; Birrell, GW; Chavchich, M; Edstein, MD; Quang, NN; Rowcliffe, K; Travers, T; van Breda, K1
Adeagbo, BA; Bolaji, OO; Olawoye, OS1
Beland, FA; Chen, S; Fang, JL; Tang, Y; Wu, Q1
Adeagbo, BA; Adehin, A; Adepiti, AO; Bolaji, OO; Elujoba, AA1
Assao, B; Blessborn, D; Coldiron, ME; Ding, J; Grais, RF; Guindo, O; Koscalova, A; Langendorf, C; Tarning, J; Winterberg, M1
Bonkian, LN; d'Alessandro, U; Kazienga, A; Lingani, M; Mens, PF; Ouédraogo, JB; Ravinetto, R; Schallig, HDFH; Sorgho, H; Tinto, H; Valéa, I; Yerbanga, I1
Bazié, T; Dabiré, RK; Ehrlich, HY; Foy, BD; Goodwin, J; Lehane, A; Neya, C; Ouattara, JM; Ouédraogo, JB; Parikh, S; Somé, FA; Wade, M; Zachari, K1
Blessborn, D; Kaewkhao, K; Tarning, J1
Burton, RB; Capel, RA; Chan, XHS; Chotsiri, P; Cremer, MA; Hanafiah, M; Hanboonkunupakarn, B; Kiechel, JR; Lee, SJ; Ogutu, B; Pike, J; Tarning, J; Taylor, WRJ; White, NJ; Win, YN1

Trials

12 trial(s) available for amodiaquine and desethylamodiaquine

ArticleYear
Effect of dose size on amodiaquine pharmacokinetics after oral administration.
    European journal of clinical pharmacology, 1987, Volume: 33, Issue:3

    Topics: Administration, Oral; Adult; Amodiaquine; Chromatography, High Pressure Liquid; Humans; Male; Middle Aged

1987
Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo.
    European journal of clinical pharmacology, 2006, Volume: 62, Issue:7

    Topics: Administration, Oral; Adult; Amodiaquine; Antihypertensive Agents; Antimalarials; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Confidence Intervals; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Debrisoquin; Drug Interactions; Humans; Losartan; Middle Aged; Phenotype; Time Factors

2006
Effect of concomitant artesunate administration and cytochrome P4502C8 polymorphisms on the pharmacokinetics of amodiaquine in Ghanaian children with uncomplicated malaria.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:12

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Aryl Hydrocarbon Hydroxylases; Child; Child, Preschool; Cytochrome P-450 CYP2C8; Drug Therapy, Combination; Female; Ghana; Humans; Malaria, Falciparum; Male; Polymorphism, Genetic; Treatment Outcome

2008
Validation of high performance liquid chromatography-electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in c
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Feb-15, Volume: 877, Issue:5-6

    Topics: Administration, Oral; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Drug Combinations; Drug Stability; Electrochemistry; Humans; Solid Phase Extraction

2009
Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.
    The Journal of infectious diseases, 2009, Dec-01, Volume: 200, Issue:11

    Topics: Amino Acid Sequence; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Child; Child, Preschool; Cohort Studies; Drug Combinations; Drug Resistance; Ethanolamines; Fluorenes; Humans; Infant; Malaria, Falciparum; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Genetic; Pyrimethamine; Sequence Alignment; Sulfadoxine; Uganda

2009
Population pharmacokinetics and pharmacodynamic considerations of amodiaquine and desethylamodiaquine in Kenyan adults with uncomplicated malaria receiving artesunate-amodiaquine combination therapy.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:6

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Artemisinins; Drug Combinations; Female; Half-Life; Humans; Kenya; Malaria, Falciparum; Male; Middle Aged; Models, Biological; Treatment Outcome; Young Adult

2010
Comparative oral bioavailability of non-fixed and fixed combinations of artesunate and amodiaquine in healthy Indian male volunteers.
    European journal of clinical pharmacology, 2011, Volume: 67, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Amodiaquine; Analysis of Variance; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Combinations; Drug Therapy, Combination; Humans; India; Male; Middle Aged; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency; Young Adult

2011
Therapeutic efficacy of artesunate-amodiaquine combinations and the plasma and saliva concentrations of desethylamodiaquine in children with acute uncomplicated Plasmodium falciparum malaria.
    American journal of therapeutics, 2013, Volume: 20, Issue:1

    Topics: Acute Disease; Administration, Oral; Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Half-Life; Humans; Infant; Malaria, Falciparum; Male; Metabolic Clearance Rate; Saliva; Treatment Outcome

2013
Pharmacokinetics of amodiaquine and desethylamodiaquine in pregnant and postpartum women with Plasmodium vivax malaria.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:9

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Female; Humans; Malaria, Vivax; Postpartum Period; Pregnancy; Young Adult

2011
Electrocardiographic study in Ghanaian children with uncomplicated malaria, treated with artesunate-amodiaquine or artemether-lumefantrine.
    Malaria journal, 2012, Dec-17, Volume: 11

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Bradycardia; Child; Child, Preschool; Drug Combinations; Electrocardiography; Ethanolamines; Female; Fluorenes; Ghana; Humans; Infant; Malaria; Male; Risk Factors

2012
Changing Antimalarial Drug Sensitivities in Uganda.
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:12

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Aspartic Acid Endopeptidases; Child; Child, Preschool; Chloroquine; Drug Resistance; Ethanolamines; Female; Fluorenes; Gene Expression; Humans; Infant; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Male; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Quinolines; Uganda; Young Adult

2017
In vivo/ex vivo efficacy of artemether-lumefantrine and artesunate-amodiaquine as first-line treatment for uncomplicated falciparum malaria in children: an open label randomized controlled trial in Burkina Faso.
    Malaria journal, 2020, Jan-06, Volume: 19, Issue:1

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Burkina Faso; Child; Child, Preschool; Drug Combinations; Drug Therapy, Combination; Female; Humans; Infant; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Male; Mass Drug Administration; Plasmodium falciparum; Treatment Failure; Treatment Outcome

2020

Other Studies

67 other study(ies) available for amodiaquine and desethylamodiaquine

ArticleYear
In vitro activity of pyronaridine against African strains of Plasmodium falciparum.
    Annals of tropical medicine and parasitology, 1992, Volume: 86, Issue:5

    Topics: Africa; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Naphthyridines; Plasmodium falciparum

1992
Effect of monodesethyl amodiaquine on human polymorphonuclear neutrophil functions in vitro.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:5

    Topics: Amodiaquine; Cell Movement; Cell-Free System; Humans; In Vitro Techniques; Neutrophils; Oxygen Consumption; Peroxidase; Phagocytosis; Superoxides

1991
Inefficacy of amodiaquine against chloroquine-resistant malaria.
    Lancet (London, England), 1991, Dec-07, Volume: 338, Issue:8780

    Topics: Amodiaquine; Animals; Chloroquine; Drug Resistance; Humans; In Vitro Techniques; Plasmodium falciparum

1991
[Preparation of monodesethylamodiaquine from human urine].
    Annales pharmaceutiques francaises, 1990, Volume: 48, Issue:1

    Topics: Amodiaquine; Antimalarials; Chromatography, Thin Layer; Female; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry

1990
The toxicity of amodiaquine and its principal metabolites towards mononuclear leucocytes and granulocyte/monocyte colony forming units.
    British journal of clinical pharmacology, 1990, Volume: 29, Issue:4

    Topics: Amodiaquine; Bone Marrow; Bone Marrow Cells; Cell Survival; Chloroquine; Colony-Forming Units Assay; Granulocytes; Humans; In Vitro Techniques; Leukocytes, Mononuclear

1990
The disposition of amodiaquine in Zambians and Nigerians with malaria.
    British journal of clinical pharmacology, 1990, Volume: 29, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Amodiaquine; Erythrocytes; Female; Humans; Malaria; Male; Middle Aged; Nigeria; Zambia

1990
A comparison of the in vitro activities of amodiaquine and desethylamodiaquine against isolates of Plasmodium falciparum.
    The American journal of tropical medicine and hygiene, 1989, Volume: 40, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Mefloquine; Plasmodium falciparum; Quinolines; Thailand

1989
[Drug sensitivity of malaria in a population of children in Pointe-Noire, Congo, in the first half of 1986].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1987, Volume: 80, Issue:3 Pt 2

    Topics: Adolescent; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Congo; Drug Resistance; Humans; Infant; Malaria; Plasmodium falciparum

1987
[Sensitivity of Plasmodium falciparum to quinolines and therapeutic strategies: comparison of the situation in Africa and Madagascar between 1983 and 1986].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1987, Volume: 80, Issue:3 Pt 2

    Topics: Amodiaquine; Angola; Animals; Antimalarials; Burkina Faso; Cameroon; Chloroquine; Drug Resistance; Humans; Madagascar; Malaria; Mefloquine; Plasmodium falciparum; Quinine; Quinolines

1987
[In vivo and in vitro sensitivity to 4-aminoquinolines of Plasmodium falciparum in Madagascar: results of a study conducted on the east coast (July 1985-July 1986)].
    Archives de l'Institut Pasteur de Madagascar, 1987, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Aminoquinolines; Amodiaquine; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Infant; Madagascar; Malaria; Plasmodium falciparum

1987
The disposition of amodiaquine in man after oral administration.
    British journal of clinical pharmacology, 1987, Volume: 23, Issue:1

    Topics: Administration, Oral; Adult; Amodiaquine; Chloroquine; Erythrocytes; Humans; Kinetics; Male; Mass Spectrometry

1987
[Pharmacokinetics of amodiaquine and prevention of Plasmodium falciparum malaria].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1985, Volume: 78, Issue:5 Pt 2

    Topics: Adult; Amodiaquine; Female; Half-Life; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum

1985
Failure to detect amodiaquine in the blood after oral administration.
    British journal of clinical pharmacology, 1985, Volume: 20, Issue:4

    Topics: Administration, Oral; Adult; Amodiaquine; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Kinetics; Male; Time Factors

1985
The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: chemical mechanisms and the effects of fluorine substitution.
    Biochemical pharmacology, 1995, Sep-28, Volume: 50, Issue:7

    Topics: Amodiaquine; Antimalarials; Biotransformation; Fluorine; Glutathione; Humans; Neutrophil Activation; Neutrophils; Serum Albumin; Tetradecanoylphorbol Acetate

1995
Pharmacokinetic and pharmacodynamic study of amodiaquine and its two metabolites after a single oral dose in human volunteers.
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:5

    Topics: Adult; Amodiaquine; Animals; Chloroquine; Diffusion Chambers, Culture; Erythrocytes; Half-Life; Humans; Leukocytes; Male; Plasmodium falciparum; Spectrophotometry, Ultraviolet

1993
In vitro activity of monodesethylamodiaquine and amopyroquine against African isolates and clones of Plasmodium falciparum.
    The American journal of tropical medicine and hygiene, 1993, Volume: 48, Issue:1

    Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Plasmodium falciparum; Regression Analysis

1993
Chemoresistance of Plasmodium falciparum in the urban region of Yaounde, Cameroon. Part 2: Evaluation of the efficacy of amodiaquine and sulfadoxine-pyrimethamine combination in the treatment of uncomplicated Plasmodium falciparum malaria in Yaounde, Came
    Tropical medicine & international health : TM & IH, 2000, Volume: 5, Issue:9

    Topics: Adolescent; Adult; Aged; Amodiaquine; Animals; Antimalarials; Cameroon; Child; Drug Combinations; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Treatment Outcome; Urban Health

2000
Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:2

    Topics: Amodiaquine; Antimalarials; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C8; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Humans; In Vitro Techniques; Isoenzymes; Liver; Mass Spectrometry; Microsomes, Liver; Models, Molecular; Recombinant Proteins; Spectrophotometry, Ultraviolet; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity

2002
Molecular epidemiology of malaria in Cameroon. XV. Experimental studies on serum substitutes and supplements and alternative culture media for in vitro drug sensitivity assays using fresh isolates of Plasmodium falciparum.
    The American journal of tropical medicine and hygiene, 2003, Volume: 69, Issue:2

    Topics: Amodiaquine; Animals; Antimalarials; Cameroon; Chloroquine; Culture Media; Humans; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Serum Albumin

2003
Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine.
    Malaria journal, 2003, Sep-19, Volume: 2

    Topics: Amodiaquine; Animals; Antimalarials; Cell Line; Chloride Channels; Chloroquine; Drug Resistance; Drug Synergism; Hydrophobic and Hydrophilic Interactions; Ion Channels; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Transfection; Verapamil

2003
Selective and sensitive liquid chromatographic assay of amodiaquine and desethylamodiaquine in whole blood spotted on filter paper.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004, Jan-05, Volume: 799, Issue:1

    Topics: Amodiaquine; Calibration; Humans; Reproducibility of Results; Sensitivity and Specificity

2004
Short report: lack of prediction of amodiaquine efficacy in treating Plasmodium falciparum malaria by in vitro tests.
    The American journal of tropical medicine and hygiene, 2004, Volume: 71, Issue:3

    Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Drug Resistance; Gabon; Humans; In Vitro Techniques; Malaria, Falciparum; Parasitic Sensitivity Tests; Predictive Value of Tests; Treatment Outcome

2004
Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:11

    Topics: Amodiaquine; Animals; Antimalarials; Culture Media; Drug Synergism; Genes, MDR; Genotype; Membrane Proteins; Membrane Transport Proteins; Plasmodium falciparum; Protozoan Proteins; Reverse Transcriptase Polymerase Chain Reaction

2004
Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y.
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2006, Volume: 6, Issue:4

    Topics: Amino Acid Substitution; Amodiaquine; Animals; Antigens, Protozoan; Antimalarials; ATP-Binding Cassette Transporters; Child, Preschool; Drug Resistance; Humans; Infant; Malaria, Falciparum; Membrane Proteins; Membrane Transport Proteins; Plasmodium falciparum; Protozoan Proteins

2006
In-vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisinin and quinine in an area of high chloroquine resistance in Rwanda.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2006, Volume: 100, Issue:6

    Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Resistance, Multiple; Female; Humans; Infant; Inhibitory Concentration 50; Malaria, Falciparum; Male; Middle Aged; Plasmodium falciparum; Quinine; Rwanda; Sesquiterpenes

2006
Practical HPLC methods for the quantitative determination of common antimalarials in Africa.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Mar-01, Volume: 847, Issue:2

    Topics: Africa; Amodiaquine; Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Humans; Pyrimethamine; Reproducibility of Results; Sulfadoxine

2007
Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.
    Clinical pharmacology and therapeutics, 2007, Volume: 82, Issue:2

    Topics: Alkynes; Amodiaquine; Antimalarials; Aryl Hydrocarbon Hydroxylases; Benzoxazines; Burkina Faso; Chromatography, High Pressure Liquid; Cyclopropanes; Cytochrome P-450 CYP2C8; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Genotype; HIV Protease Inhibitors; Humans; Lopinavir; Malaria, Falciparum; Models, Biological; Polymorphism, Genetic; Pyridines; Pyrimidinones; Pyrones; Reverse Transcriptase Inhibitors; Saquinavir; Spectrophotometry, Ultraviolet; Sulfonamides; Treatment Outcome; Trimethoprim

2007
Prevalent pfmdr1 n86y mutant Plasmodium falciparum in Madagascar despite absence of pfcrt mutant strains.
    The American journal of tropical medicine and hygiene, 2007, Volume: 76, Issue:6

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Humans; Inhibitory Concentration 50; Madagascar; Malaria, Falciparum; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Prevalence; Protozoan Proteins; Quinine; Rural Population

2007
Population pharmacokinetics of amodiaquine and desethylamodiaquine in pediatric patients with uncomplicated falciparum malaria.
    Journal of pharmacokinetics and pharmacodynamics, 2007, Volume: 34, Issue:5

    Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Humans; Infant; Malaria, Falciparum; Models, Biological

2007
A field-adapted HPLC method for determination of amodiaquine and its metabolite in whole blood dried on filter paper.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Nov-01, Volume: 859, Issue:1

    Topics: Amodiaquine; Antimalarials; Calibration; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Time Factors

2007
Simultaneous determination of amodiaquine and its active metabolite in human blood by ion-pair liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Dec-01, Volume: 860, Issue:1

    Topics: Acetonitriles; Amodiaquine; Chromatography, High Pressure Liquid; Drug Stability; Humans; Male; Sensitivity and Specificity; Tandem Mass Spectrometry

2007
Short report: polymorphisms in the pfcrt and pfmdr1 genes of Plasmodium falciparum and in vitro susceptibility to amodiaquine and desethylamodiaquine.
    The American journal of tropical medicine and hygiene, 2007, Volume: 77, Issue:6

    Topics: Amino Acid Sequence; Amodiaquine; Animals; Antimalarials; Base Sequence; Colombia; Drug Resistance; Inhibitory Concentration 50; Membrane Transport Proteins; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Single Nucleotide; Protozoan Proteins

2007
Determination of N-desethylamodiaquine by hydrophilic interaction liquid chromatography with tandem mass spectrometry: application to in vitro drug metabolism studies.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Feb-15, Volume: 863, Issue:1

    Topics: Amodiaquine; Antimalarials; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Humans; In Vitro Techniques; Indicators and Reagents; Kinetics; Microsomes, Liver; Reference Standards; Reproducibility of Results; Solvents; Tandem Mass Spectrometry

2008
Pharmacokinetic determinants of the window of selection for antimalarial drug resistance.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5

    Topics: Algorithms; Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Computer Simulation; Drug Resistance; Malaria; Mefloquine; Models, Theoretical; Pyrimethamine; Quinine

2008
Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt.
    Parasitology, 2008, Volume: 135, Issue:5

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Colombia; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Protozoan Proteins

2008
In vitro activity of ferroquine is independent of polymorphisms in transport protein genes implicated in quinoline resistance in Plasmodium falciparum.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8

    Topics: Aminoquinolines; Amodiaquine; Animals; Chloroquine; Drug Resistance, Bacterial; Ferrous Compounds; Mefloquine; Membrane Transport Proteins; Metallocenes; Microsatellite Repeats; Molecular Structure; Plasmodium falciparum; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Protozoan Proteins; Quinolines

2008
Biological measure of compliance to Artesunate plus Amodiaquine association: interest in a Mono-Desethyl-Amodiaquine blood assay?
    Acta tropica, 2009, Volume: 110, Issue:1

    Topics: Adult; Amodiaquine; Animals; Antimalarials; Artemisinins; Chromatography, High Pressure Liquid; Drug Combinations; Female; Humans; Malaria; Male; Patient Compliance; Young Adult

2009
Synergy of mefloquine activity with atorvastatin, but not chloroquine and monodesethylamodiaquine, and association with the pfmdr1 gene.
    The Journal of antimicrobial chemotherapy, 2010, Volume: 65, Issue:7

    Topics: Amodiaquine; Antimalarials; Atorvastatin; Chloroquine; DNA, Protozoan; Drug Synergism; Gene Dosage; Genotype; Heptanoic Acids; Humans; Inhibitory Concentration 50; Mefloquine; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrroles

2010
Plasmodium falciparum: Solanum nudum SN-1 steroid antiplasmodial activity when combined with antimalarial drugs.
    Experimental parasitology, 2011, Volume: 127, Issue:1

    Topics: Amodiaquine; Antimalarials; Artemisinins; Atovaquone; Chloroquine; Drug Synergism; Erythrocytes; Flow Cytometry; Humans; Phytosterols; Plasmodium falciparum; Quinine; Solanum; Trophozoites

2011
In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire).
    African health sciences, 2010, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Cote d'Ivoire; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Microbial Sensitivity Tests; Middle Aged; Phenanthrenes; Plasmodium falciparum; Quinine; Young Adult

2010
In vitro activity of Proveblue (methylene blue) on Plasmodium falciparum strains resistant to standard antimalarial drugs.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:5

    Topics: Amodiaquine; Antimalarials; Chloroquine; Ethanolamines; Fluorenes; Inhibitory Concentration 50; Lumefantrine; Mefloquine; Methylene Blue; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinine

2011
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Nov-22, Volume: 108, Issue:47

    Topics: Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Blotting, Southern; Dose-Response Relationship, Drug; Ethanolamines; Fluorenes; Genetic Vectors; Germ Cells, Plant; Green Fluorescent Proteins; Luciferases; Lumefantrine; Malaria; Methylene Blue; Naphthyridines; Plasmodium falciparum; Quinolines; Sexual Development

2011
In vitro assessment of drug resistance in Plasmodium falciparum in five States of India.
    The Indian journal of medical research, 2012, Volume: 135, Issue:4

    Topics: Amodiaquine; Artemisinins; Artesunate; Biomarkers, Pharmacological; Chloroquine; Drug Resistance; Humans; In Vitro Techniques; India; Mefloquine; Membrane Transport Proteins; Mutation; Plasmodium falciparum; Protozoan Proteins

2012
Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax malaria during and after pregnancy.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:11

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Biotransformation; Body Weight; Drug Administration Schedule; Female; Humans; Malaria, Vivax; Nonlinear Dynamics; Plasmodium vivax; Pregnancy; Pregnancy Complications, Parasitic; Secondary Prevention

2012
In-vitro inhibitory effect of Tualang honey on cytochrome P450 2C8 activity.
    The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:12

    Topics: Amodiaquine; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Food-Drug Interactions; Honey; Inhibitory Concentration 50; Kinetics; Recombinant Proteins

2012
Assessing the cost-benefit effect of a Plasmodium falciparum drug resistance mutation on parasite growth in vitro.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:2

    Topics: Amodiaquine; Antimalarials; Biological Transport; Chloroquine; Drug Resistance; Genetic Fitness; Genotype; Malaria, Falciparum; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Mutation; Plasmodium falciparum

2013
High-throughput analysis of antimalarial susceptibility data by the WorldWide Antimalarial Resistance Network (WWARN) in vitro analysis and reporting tool.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:7

    Topics: Amodiaquine; Antimalarials; Artemisinins; Automation, Laboratory; Chloroquine; Drug Resistance; Drug Therapy, Combination; High-Throughput Screening Assays; Internet; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinine

2013
Plasmodium falciparum Polymorphisms associated with ex vivo drug susceptibility and clinical effectiveness of artemisinin-based combination therapies in Benin.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:1

    Topics: Amodiaquine; Antimalarials; Artemisinins; Drug Combinations; Ethanolamines; Female; Fluorenes; Humans; Inhibitory Concentration 50; Lumefantrine; Male; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Single Nucleotide; Protozoan Proteins; Pyrimethamine; Quinine; Sulfadoxine

2014
Role of Pfmdr1 in in vitro Plasmodium falciparum susceptibility to chloroquine, quinine, monodesethylamodiaquine, mefloquine, lumefantrine, and dihydroartemisinin.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:12

    Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Biological Transport; Child; Chloroquine; Drug Resistance; Erythrocytes; Ethanolamines; Female; Fluorenes; Gene Expression; Haplotypes; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Male; Mefloquine; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Single Nucleotide; Quinine; Senegal

2014
Inhibitory effect of six herbal extracts on CYP2C8 enzyme activity in human liver microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:5

    Topics: Amodiaquine; Cytochrome P-450 CYP2C8; Humans; Inhibitory Concentration 50; Microsomes, Liver; Pioglitazone; Plant Extracts; Thiazolidinediones

2015
Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:6

    Topics: Amodiaquine; Antimalarials; Artemisinins; Child, Preschool; Chloroquine; Clinical Trials as Topic; Ethanolamines; Fluorenes; Humans; Infant; Lumefantrine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinine; Quinolines; Uganda

2015
Functional characterization of 12 allelic variants of CYP2C8 by assessment of paclitaxel 6α-hydroxylation and amodiaquine N-deethylation.
    Drug metabolism and pharmacokinetics, 2015, Volume: 30, Issue:5

    Topics: Alleles; Amodiaquine; Animals; Aryl Hydrocarbon Hydroxylases; Chlorocebus aethiops; Cloning, Molecular; COS Cells; Cytochrome P-450 CYP2C8; Genetic Variation; Genetic Vectors; Humans; Hydroxylation; Models, Molecular; Paclitaxel; Polymorphism, Genetic

2015
Application of an LC-MS/MS method for reliable determination of amodiaquine, N-desethylamodiaquine, artesunate and dihydroartemisinin in human plasma for a bioequivalence study in healthy Indian subjects.
    Journal of pharmaceutical and biomedical analysis, 2016, May-30, Volume: 124

    Topics: Amodiaquine; Artemisinins; Artesunate; Chromatography, Liquid; Humans; India; Tandem Mass Spectrometry; Therapeutic Equivalency

2016
Plasmodium falciparum In Vitro Resistance to Monodesethylamodiaquine, Dakar, Senegal, 2014.
    Emerging infectious diseases, 2016, Volume: 22, Issue:5

    Topics: Amodiaquine; Antimalarials; Drug Resistance; Female; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Male; Parasitic Sensitivity Tests; Plasmodium falciparum; Prevalence; Senegal

2016
Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance.
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Amodiaquine; Antimalarials; Biological Transport; Chloroquine; Drug Design; Drug Resistance; Heme; Hemin; Hydrophobic and Hydrophilic Interactions; Plasmodium falciparum; Quinolines; Structure-Activity Relationship; Vacuoles

2016
Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine.
    British journal of clinical pharmacology, 2017, Volume: 83, Issue:3

    Topics: Activation, Metabolic; Amodiaquine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Glutathione; Humans; Microsomes, Liver; Recombinant Proteins

2017
Association between Polymorphisms in the Pf
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:3

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Asparagine; ATP-Binding Cassette Transporters; Chloroquine; Doxycycline; Drug Resistance; Ethanolamines; Fluorenes; Gene Expression; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Protein Isoforms; Protozoan Proteins; Quinine; Quinolines; Repetitive Sequences, Amino Acid; Senegal

2017
Confirmation of Plasmodium falciparum in vitro resistance to monodesethylamodiaquine and chloroquine in Dakar, Senegal, in 2015.
    Malaria journal, 2017, 03-16, Volume: 16, Issue:1

    Topics: Amodiaquine; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Therapy, Combination; Plasmodium falciparum; Senegal

2017
Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity.
    Toxicology letters, 2017, Jun-05, Volume: 275

    Topics: Amodiaquine; Biocatalysis; Chemical and Drug Induced Liver Injury; Escherichia coli; Glutathione Transferase; Humans; In Vitro Techniques; Isoenzymes; Microsomes, Liver; NAD(P)H Dehydrogenase (Quinone); Recombinant Proteins; Transfection

2017
Comparison of the Pharmacokinetics and Ex Vivo Antimalarial Activities of Artesunate-Amodiaquine and Artemisinin-Piperaquine in Healthy Volunteers for Preselection Malaria Therapy.
    The American journal of tropical medicine and hygiene, 2018, Volume: 99, Issue:1

    Topics: Amodiaquine; Antimalarials; Area Under Curve; Artemisinins; Biotransformation; Drug Administration Schedule; Drug Combinations; Half-Life; Healthy Volunteers; Humans; Malaria, Falciparum; Male; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Tablets; Young Adult

2018
Moringa oleifera leaf powder alters the pharmacokinetics of amodiaquine in healthy human volunteers.
    Journal of clinical pharmacy and therapeutics, 2018, Volume: 43, Issue:5

    Topics: Adult; Amodiaquine; Antimalarials; Female; Healthy Volunteers; Herb-Drug Interactions; Humans; Male; Moringa oleifera; Plant Leaves; Powders; Tablets; Young Adult

2018
Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells.
    Toxicology in vitro : an international journal published in association with BIBRA, 2020, Volume: 62

    Topics: Amodiaquine; Apoptosis; Cell Survival; Cytochrome P-450 Enzyme System; Hep G2 Cells; Humans; Isoenzymes; MAP Kinase Signaling System; Proto-Oncogene Proteins c-bcl-2

2020
Influence of MAMA decoction, an Herbal Antimalarial, on the Pharmacokinetics of Amodiaquine in Mice.
    European journal of drug metabolism and pharmacokinetics, 2020, Volume: 45, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Drug Combinations; Drug Interactions; Female; Herb-Drug Interactions; Malaria; Male; Mice; Models, Animal; Plant Extracts; Plant Leaves

2020
Adherence and Population Pharmacokinetic Properties of Amodiaquine When Used for Seasonal Malaria Chemoprevention in African Children.
    Clinical pharmacology and therapeutics, 2020, Volume: 107, Issue:5

    Topics: Africa; Amodiaquine; Antimalarials; Case-Control Studies; Chemoprevention; Child, Preschool; Female; Humans; Infant; Malaria; Male; Medication Adherence; Models, Biological; Prospective Studies; Seasons

2020
Investigating selected host and parasite factors potentially impacting upon seasonal malaria chemoprevention in Bama, Burkina Faso.
    Malaria journal, 2020, Jul-06, Volume: 19, Issue:1

    Topics: Amodiaquine; Antimalarials; Burkina Faso; Chemoprevention; Child, Preschool; Cross-Sectional Studies; Cytochrome P-450 CYP2C8; Drug Resistance; Female; Genes, Protozoan; Humans; Infant; Malaria, Falciparum; Male; Plasma; Polymorphism, Genetic

2020
High-throughput quantitation method for amodiaquine and desethylamodiaquine in plasma using supported liquid extraction technology.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2021, Aug-01, Volume: 1179

    Topics: Amodiaquine; Antimalarials; Chromatography, Liquid; High-Throughput Screening Assays; Humans; Limit of Detection; Linear Models; Liquid-Liquid Extraction; Reproducibility of Results; Tandem Mass Spectrometry

2021
Cardiovascular concentration-effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies.
    British journal of clinical pharmacology, 2023, Volume: 89, Issue:3

    Topics: Amodiaquine; Animals; Antimalarials; Kenya; Malaria; Mice

2023