amodiaquine and clozapine

amodiaquine has been researched along with clozapine in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's7 (87.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A1
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Hayen, H; Karst, U; Lohmann, W1
Baumann, A; Bomke, S; Jahn, S; Karst, U; Lohmann, W1
Kalyanaraman, N; Subramanian, R; Zhu, X1
Lobach, AR; Uetrecht, J1

Other Studies

8 other study(ies) available for amodiaquine and clozapine

ArticleYear
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7

    Topics: Glutathione; Pharmacology; Sulfur Radioisotopes

2011
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:5

    Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
Covalent protein modification by reactive drug metabolites using online electrochemistry/liquid chromatography/mass spectrometry.
    Analytical chemistry, 2008, Dec-15, Volume: 80, Issue:24

    Topics: Acetaminophen; Amodiaquine; Chromatography, Liquid; Clozapine; Electrochemistry; Humans; Lactoglobulins; Mass Spectrometry; Serum Albumin; Spectroscopy, Fourier Transform Infrared

2008
A ferrocene-based reagent for the conjugation and quantification of reactive metabolites.
    Analytical and bioanalytical chemistry, 2012, Volume: 402, Issue:1

    Topics: Amodiaquine; Antimalarials; Antipsychotic Agents; Chromatography, Liquid; Clozapine; Ferrous Compounds; Glutathione; Metallocenes; Propionates; Spectrometry, Mass, Electrospray Ionization

2012
Enhanced screening of glutathione-trapped reactive metabolites by in-source collision-induced dissociation and extraction of product ion using UHPLC-high resolution mass spectrometry.
    Analytical chemistry, 2011, Dec-15, Volume: 83, Issue:24

    Topics: Amodiaquine; Chromatography, High Pressure Liquid; Clozapine; Diclofenac; Glutathione; Humans; Ions; Mass Spectrometry; Microsomes, Liver; NADP; Piperazines

2011
Involvement of myeloperoxidase and NADPH oxidase in the covalent binding of amodiaquine and clozapine to neutrophils: implications for drug-induced agranulocytosis.
    Chemical research in toxicology, 2014, Apr-21, Volume: 27, Issue:4

    Topics: Agranulocytosis; Amodiaquine; Animals; Clozapine; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Female; Mice; Mice, Knockout; NADPH Oxidases; Neutrophils; Peroxidase; Protein Binding; Rats; Rats, Sprague-Dawley

2014