amobarbital and caffeine

amobarbital has been researched along with caffeine in 48 studies

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	41 (85.42)	18.7374
1990's	3 (6.25)	18.2507
2000's	3 (6.25)	29.6817
2010's	1 (2.08)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Cohn, M; Cohn, ML; Kraynack, BJ; Taylor, FH	1
Dressler, F	1
Chae, YS; Shelver, WH	1
Iagodka, PN; Kalachev, BP	1
Kalachev, BP	1
Suzuki, EM	1
McCall, WV	1
Altschuld, RA; Angelo, JP; Ganote, CE; Vander Heide, RS	1
Ganote, CE; Vander Heide, RS	2
Benkö, A	1
Mangan, GL; White, KD	1
Brodie, BB; Koppanyi, T; Maling, HM; Saul, W	1
Klapper, JA; McColloch, MA	1
Izquierdo, I	1
Gorodetzky, CW; Kullberg, MP	1
Ban, TA; Lehmann, HE	1
Brinkmann, G; Guthy, H; Hildgen, J	1
Raymann, F	1
Faust, B	1
Poliak, AI; Shmilovich, LA	1
Sabbagh, M	1
Schilffarth, H	1
Gerbold, H	1
Heide, M	1
Barnett, HJ; Richards, RN	1
Aprikian, GV; Buniatian, HC; Hovhannissian, VS	1
Priyatkina, TN; Sytinskii, IA	1
McMartin, C; Street, HV	1
Blake, MI; Lin, SL	1
Kalow, W	1
Mettler, L; Sadighi, R	1
Thoma, E; Thoma, H	1
Atkins, CM; Li, YP; Reid, MB; Sweatt, JD	1
KHMYZNIKOVA, EP; MAKKAVEISKII, PA	1
AMIRAGOVA, MG	1
LYNN, R	1
YAMAMOTO, H	1
JACOBZINER, H; RAYBIN, HW	1
CARSTEN, ME; MOMMAERTS, WF	1
GRAY, CP; HAYDON, GB; HECKER, SP; LEE, PR; YOUNG, JV	1
BARRY, H; MILLER, NE	1
BAZHIN, EF	1
IAGODKA, PN; NARODITSKAIA, VF; POTAPOVA, AA; SMOLINA, AI	1

Reviews

1 review(s) available for amobarbital and caffeine

Article	Year
RUSSIAN THEORY AND RESEARCH ON SCHIZOPHRENIA. Psychological bulletin, 1963, Volume: 60 Topics: Amobarbital; Bromides; Caffeine; Cerebral Cortex; Chlorpromazine; Conditioning, Psychological; Convulsive Therapy; Electroconvulsive Therapy; Electroencephalography; Humans; Insulin; Orientation; Psychological Tests; Research; Russia; Schizophrenia; Sleep; Sodium; Sympathetic Nervous System; USSR	1963

Trials

2 trial(s) available for amobarbital and caffeine

Article	Year
Strength of the nervous system as a function of personality type and level of arousal. Behaviour research and therapy, 1972, Volume: 10, Issue:2 Topics: Adult; Afterimage; Amobarbital; Arousal; Caffeine; Depression, Chemical; Extraversion, Psychological; Higher Nervous Activity; Humans; Male; Neural Inhibition; Neurotic Disorders; Personality; Personality Inventory; Psychophysiology; Reaction Time; Stimulation, Chemical; Synaptic Transmission	1972
Effects of psychoactive drugs on conflict avoidance behavior in human subjects. Activitas nervosa superior, 1971, Volume: 13, Issue:2 Topics: Adolescent; Adult; Amobarbital; Avoidance Learning; Caffeine; Child; Chlordiazepoxide; Chlorpromazine; Conflict, Psychological; Electroshock; Female; Haloperidol; Humans; Male; Meprobamate; Methamphetamine; Neurotic Disorders; Pentylenetetrazole; Perphenazine; Placebos; Tranquilizing Agents	1971

Article

Year

Strength of the nervous system as a function of personality type and level of arousal.

Behaviour research and therapy, 1972, Volume: 10, Issue:2

Topics: Adult; Afterimage; Amobarbital; Arousal; Caffeine; Depression, Chemical; Extraversion, Psychological; Higher Nervous Activity; Humans; Male; Neural Inhibition; Neurotic Disorders; Personality; Personality Inventory; Psychophysiology; Reaction Time; Stimulation, Chemical; Synaptic Transmission

1972

Effects of psychoactive drugs on conflict avoidance behavior in human subjects.

Activitas nervosa superior, 1971, Volume: 13, Issue:2

Topics: Adolescent; Adult; Amobarbital; Avoidance Learning; Caffeine; Child; Chlordiazepoxide; Chlorpromazine; Conflict, Psychological; Electroshock; Female; Haloperidol; Humans; Male; Meprobamate; Methamphetamine; Neurotic Disorders; Pentylenetetrazole; Perphenazine; Placebos; Tranquilizing Agents

1971

Other Studies

45 other study(ies) available for amobarbital and caffeine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Comparisons between the antianesthetic action of dibutyryl cyclic AMP and analeptic drugs on amobarbital-induced narcosis in the rat. Pharmacology, 1976, Volume: 14, Issue:1 Topics: Amobarbital; Amphetamines; Anesthetics; Animals; Benzamides; Bucladesine; Caffeine; Central Nervous System Stimulants; Doxapram; Male; Pentylenetetrazole; Picrotoxin; Rats; Strychnine; Theophylline	1976
[The antipyretic effect of Lonarid N in children]. Fortschritte der Medizin, 1979, Apr-05, Volume: 97, Issue:13 Topics: Acetaminophen; Amobarbital; Caffeine; Child; Child, Preschool; Codeine; Drug Combinations; Drug Evaluation; Fever; Humans; Infant; Suppositories	1979
Quantitative determination of theophylline in pharmaceutical dosage forms by differential spectrophotometry. Journal of pharmaceutical sciences, 1976, Volume: 65, Issue:8 Topics: Amobarbital; Caffeine; Capsules; Chemical Phenomena; Chemistry; Drug Stability; Ephedrine; Methods; Spectrophotometry, Ultraviolet; Tablets; Theobromine; Theophylline	1976
[Evaluation of the effectiveness of treatment of border-line neuropsychiatric disorders with amytal-caffeine]. Sovetskaia meditsina, 1976, Issue:11 Topics: Adolescent; Adult; Amobarbital; Caffeine; Drug Combinations; Drug Evaluation; Female; Humans; Male; Middle Aged; Neurotic Disorders	1976
[Assessment of the effectiveness of autogenic training in the complex treatment of neurotic and psychopathic states]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1976, Volume: 76, Issue:11 Topics: Adolescent; Adult; Amitriptyline; Amobarbital; Antisocial Personality Disorder; Autogenic Training; Caffeine; Chlorpromazine; Drug Combinations; Female; Humans; Hysteria; Male; Middle Aged; Neurotic Disorders	1976
Fourier transform infrared analyses of some particulate drug mixtures using a diamond anvil cell with a beam condenser and an infrared microscope. Journal of forensic sciences, 1992, Volume: 37, Issue:2 Topics: Amobarbital; Aspirin; Barbiturates; Caffeine; Chlordiazepoxide; Cocaine; Diphenoxylate; Drug Combinations; Ephedrine; Heroin; Illicit Drugs; Meperidine; Methamphetamine; Niacinamide; Phenacetin; Powders; Secobarbital; Spectrophotometry, Infrared	1992
The addition of intravenous caffeine during an amobarbital interview. Journal of psychiatry & neuroscience : JPN, 1992, Volume: 17, Issue:5 Topics: Adult; Aged; Amobarbital; Caffeine; Catatonia; Female; Hallucinations; Humans; Injections, Intravenous; Male; Middle Aged; Narcotherapy; Tachycardia	1992
Energy dependence of contraction band formation in perfused hearts and isolated adult myocytes. The American journal of pathology, 1986, Volume: 125, Issue:1 Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Amobarbital; Animals; Caffeine; Calcium; Calcium Channel Blockers; Cell Separation; Dinitrophenols; Energy Metabolism; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Perfusion; Rats; Rats, Inbred Strains	1986
Morphologic aspects of reperfusion injury. Journal of molecular and cellular cardiology, 1986, Volume: 18 Suppl 4 Topics: Adenosine Triphosphate; Amobarbital; Animals; Caffeine; Calcium; Coronary Circulation; Coronary Disease; Heart; Mitochondria, Heart; Myocardium; Oxygen; Potassium Cyanide; Rats	1986
Caffeine-induced myocardial injury in calcium-free perfused rat hearts. The American journal of pathology, 1985, Volume: 118, Issue:1 Topics: Amobarbital; Animals; Caffeine; Calcium; Creatine Kinase; Extracellular Space; Heart Injuries; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Perfusion; Rats; Rats, Inbred Strains; Sarcolemma	1985
[Post-mortem toxicological analysis and comparison of concentrations of drugs in organs and bones]. Acta pharmaceutica Hungarica, 1985, Volume: 55, Issue:4 Topics: Amobarbital; Autopsy; Bone and Bones; Caffeine; Gas Chromatography-Mass Spectrometry; Glutethimide; Humans; Phenacetin; Phenobarbital; Tissue Distribution	1985
Jumping activity induced by sodium 5-(1,3-dimethylbutyl)-5-ethyl barbiturate. I. The role of the sympathetic nervous system. The Journal of pharmacology and experimental therapeutics, 1970, Volume: 172, Issue:1 Topics: Adrenergic beta-Antagonists; Amino Alcohols; Amobarbital; Animals; Anticonvulsants; Barbiturates; Benzazepines; Blood Glucose; Body Temperature; Brain Chemistry; Caffeine; Chlordiazepoxide; Chlorisondamine; Dextroamphetamine; Diazepam; Drug Synergism; Fatty Acids, Nonesterified; Male; Mice; Motor Activity; Pempidine; Pentobarbital; Pentylenetetrazole; Phentolamine; Propranolol; Sympathetic Nervous System	1970
Personality and reactivity to stimulants and depressants. The Journal of nervous and mental disease, 1972, Volume: 154, Issue:6 Topics: Amobarbital; Antidepressive Agents; Benzoates; Caffeine; Cognition; Extraversion, Psychological; Female; Humans; Hypnotics and Sedatives; Introversion, Psychological; Male; Methylphenidate; MMPI; Motor Skills; Personality; Psychological Tests; Secobarbital	1972
Effect on pseudoconditioning of drugs with known central nervous activity. Psychopharmacologia, 1974, Volume: 38, Issue:3 Topics: Amobarbital; Animals; Avoidance Learning; Behavior, Animal; Caffeine; Cannabis; Chlorpromazine; Conditioning, Psychological; Depression, Chemical; Diazepam; Dibenzylchlorethamine; Female; Meprobamate; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Rats; Stimulation, Chemical; Strychnine; Trimethadione	1974
Studies on the use of XAD-2 resin for detection of abused drugs in urine. Clinical chemistry, 1974, Volume: 20, Issue:2 Topics: Amobarbital; Amphetamine; Aspirin; Caffeine; Carbon Radioisotopes; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cocaine; Codeine; Evaluation Studies as Topic; Glucuronates; Humans; Hydrolysis; Meperidine; Meprobamate; Mescaline; Methadone; Methods; Microchemistry; Morphine; Nalorphine; Naloxone; Pentobarbital; Secobarbital; Substance-Related Disorders	1974
[Treatment of vascular headache]. Medizinische Monatsschrift, 1969, Volume: 23, Issue:9 Topics: Adult; Amobarbital; Caffeine; Codeine; Ergotamine; Female; Headache; Humans; Male; Middle Aged; Phenols; Vascular Headaches; Vasomotor System	1969
[Pain from the viewpoint of the general practitioner. Experiences with a new analgesic]. Medizinische Monatsschrift, 1969, Volume: 23, Issue:8 Topics: Adolescent; Adult; Aged; Amobarbital; Analgesics; Antipyrine; Caffeine; Family Practice; Humans; Middle Aged; Pain; Phenazines; Pyrazines	1969
[Ambulatory experiences with a new analgesic]. Zeitschrift fur Allgemeinmedizin, 1969, Nov-20, Volume: 45, Issue:32 Topics: Adult; Aged; Ambulatory Care; Aminopyrine; Amobarbital; Analgesics; Antipyrine; Caffeine; Female; Humans; Male; Middle Aged; Pain; Propylamines; Psychophysiologic Disorders	1969
[Cessation of status epilepticus and serial seizures with amytal-caffeine]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1970, Volume: 70, Issue:1 Topics: Amobarbital; Caffeine; Epilepsy; Humans; Injections, Intravenous; Injections, Subcutaneous	1970
[Therapy of the vasomotor headache in childhood]. Medizinische Monatsschrift, 1970, Volume: 24, Issue:9 Topics: Adolescent; Amines; Amobarbital; Caffeine; Child; Child, Preschool; Codeine; Ergotamine; Headache; Humans; Phenols; Vascular Headaches	1970
[Experiences with Ergo-Lonarid in the treatment of headaches in otorhinolaryngological practice]. Deutsches medizinisches Journal, 1970, Volume: 21, Issue:2 Topics: Amobarbital; Caffeine; Codeine; Ergotamine; Headache; Humans; Otorhinolaryngologic Diseases; Phenols	1970
[Treatment of vascular headaches with a new compound preparation]. Zeitschrift fur Allgemeinmedizin, 1970, Feb-28, Volume: 46, Issue:6 Topics: Acetaminophen; Adult; Amobarbital; Analgesics; Caffeine; Codeine; Ergotamine; Female; Headache; Humans; Male; Middle Aged; Tartrates; Vascular Headaches	1970
[Treatment of headache with Ergo-Lonarid]. Therapie der Gegenwart, 1971, Volume: 110, Issue:3 Topics: Amobarbital; Analgesics; Caffeine; Codeine; Diagnosis, Differential; Ergotamine; Headache; Humans	1971
Paroxysmal dystonic choreoathetosis. A family study and review of the literature. Neurology, 1968, Volume: 18, Issue:5 Topics: Adult; Aged; Amobarbital; Athetosis; Atropine; Benzoates; Caffeine; Child, Preschool; Chorea; Coffee; Consciousness; Electroencephalography; Fatigue; Female; Functional Laterality; Humans; Male; Middle Aged; Motion Pictures; Muscles; Muscular Diseases; Neostigmine; Pedigree; Phenobarbital; Phenytoin; Phytotherapy; Stress, Physiological; Suggestion	1968
The participation of N-acetyl-L-aspartic acid in brain metabolism. Journal of neurochemistry, 1965, Volume: 12, Issue:8 Topics: Acetylcholine; Aminobutyrates; Amobarbital; Animals; Aspartic Acid; Brain; Caffeine; Glucose; In Vitro Techniques; Mice; Muscle Contraction; Physical Exertion; Rats	1965
Effect of certain drugs on the gamma-amino-butyric acid system of the central nervous system. Biochemical pharmacology, 1966, Volume: 15, Issue:1 Topics: Amino Alcohols; Aminobutyrates; Amobarbital; Animals; Brain; Butyrophenones; Caffeine; Carboxy-Lyases; Hypnotics and Sedatives; In Vitro Techniques; Meprobamate; Methylphenidate; Pentylenetetrazole; Picrotoxin; Rats; Subcellular Fractions; Transaminases	1966
Gas-liquid chromatography of submicrogram amounts of drugs. II. Analysis of barbiturates and related drugs in biological media. Journal of chromatography, 1966, Volume: 23, Issue:2 Topics: Amobarbital; Aspirin; Barbiturates; Bemegride; Caffeine; Chromatography, Gas; Glutethimide; Hexobarbital; Humans; Liver Extracts; Pentobarbital; Salicylates; Secobarbital	1966
Determination of acetylsalicylic acid and barbiturate combinations in dosage forms. Journal of pharmaceutical sciences, 1967, Volume: 56, Issue:1 Topics: Amobarbital; Aspirin; Atropa belladonna; Barbiturates; Caffeine; Dextroamphetamine; Dosage Forms; Phenacetin; Phenobarbital; Plants, Medicinal; Plants, Toxic; Potentiometry	1967
Metabolism of psychoactive drugs. Progress in neuro-psychopharmacology & biological psychiatry, 1982, Volume: 6, Issue:4-6 Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Amobarbital; Biotransformation; Caffeine; Ethanol; Ethnicity; Gene Frequency; Genetic Variation; Humans; Nortriptyline; Psychotropic Drugs	1982
[Gynecologic-obstetric pain therapy. Use of Lonarid N]. ZFA. Zeitschrift fur Allgemeinmedizin, 1980, Feb-20, Volume: 56, Issue:5 Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Caffeine; Codeine; Drug Combinations; Dysmenorrhea; Endometritis; Episiotomy; Female; Humans; Middle Aged; Pain; Parametritis; Pelvic Inflammatory Disease; Premenstrual Syndrome	1980
[Analgesic therapy in the orthopedic office. Experiences with Lonarid N]. ZFA. Zeitschrift fur Allgemeinmedizin, 1980, Jul-31, Volume: 56, Issue:21 Topics: Acetaminophen; Amobarbital; Analgesia; Bone Diseases; Caffeine; Codeine; Drug Combinations; Humans	1980
Mitochondria mediate tumor necrosis factor-alpha/NF-kappaB signaling in skeletal muscle myotubes. Antioxidants & redox signaling, 1999,Spring, Volume: 1, Issue:1 Topics: Amobarbital; Animals; Antimycin A; Caffeine; Ceramides; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Melitten; Mitochondria, Muscle; Muscle Development; Muscle, Skeletal; NF-kappa B; Nifedipine; Oleic Acids; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Reactive Oxygen Species; Recombinant Proteins; Rotenone; Ruthenium Red; Signal Transduction; Tumor Necrosis Factor-alpha	1999
[Effect of elevated functional stress on cholesterin and sugar in blood in peptic ulcer during the treatment with sleep]. Terapevticheskii arkhiv, 1956, Volume: 28, Issue:8 Topics: Amobarbital; Caffeine; Carbohydrates; Cholesterol; Humans; Peptic Ulcer; Sleep	1956
[Effect of caffeine and barbamil on the secretory cycle of the thyroid gland]. Biulleten' eksperimental'noi biologii i meditsiny, 1962, Volume: 54 Topics: Amobarbital; Biological Transport; Caffeine; Humans; Iodine; Iodine Radioisotopes; Radioisotopes; Thyroid Gland; Viscera	1962
THE CENTRAL EFFECTS OF XYLOPININE IN MICE. Japanese journal of pharmacology, 1963, Volume: 13 Topics: Amobarbital; Berberine Alkaloids; Caffeine; Central Nervous System; Chlorpromazine; Hypnotics and Sedatives; Methamphetamine; Mice; Nervous System; Pharmacology; Quinolizines; Research; Tetrabenazine; Toxicology; Tranquilizing Agents	1963
ISONIAZID INTOXICATIONS. New York state journal of medicine, 1964, Mar-01, Volume: 64 Topics: Amobarbital; Anti-Bacterial Agents; Caffeine; Child; Ions; Isoniazid; New York; Phenylephrine; Phenytoin; Protein Synthesis Inhibitors; Pyridoxine; Sodium; Sodium, Dietary; Tetracycline; Toxicology	1964
THE ACCUMULATION OF CALCIUM IONS BY SARCOTUBULAR VESICLES. The Journal of general physiology, 1964, Volume: 48 Topics: Adenine Nucleotides; Adenosine Triphosphatases; Adenosine Triphosphate; Amobarbital; Animals; Anti-Bacterial Agents; Antimycin A; Arsenic; Caffeine; Calcium; Calcium-Transporting ATPases; Chloromercuribenzoates; Dinitrophenols; Iodoacetates; Ions; Metabolism; Microsomes; Muscle Proteins; Nucleotides; Oxalates; Peptides; Pharmacology; Phosphates; Potassium; Pyridoxal Phosphate; Quinacrine; Rabbits; Research; Sodium; Sulfhydryl Compounds; Thiourea	1964
NEPHROPATHY ASSOCIATED WITH THE USE OF ANALGESIC MEDICATIONS. Annals of internal medicine, 1965, Volume: 62 Topics: Acute Kidney Injury; Amobarbital; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antipyretics; Aspirin; Caffeine; Dextroamphetamine; Drug Therapy; Escherichia coli Infections; Headache; Humans; Kidney Diseases; Kidney Papillary Necrosis; Neurotic Disorders; Pathology; Phenacetin; Pyelonephritis; Renal Insufficiency; Toxicology; Urinary Tract Infections; Urography	1965
COMPARISON OF DRUG EFFECTS ON APPROACH, AVOIDANCE, AND ESCAPE MOTIVATION. Journal of comparative and physiological psychology, 1965, Volume: 59 Topics: Amobarbital; Avoidance Learning; Caffeine; Chlordiazepoxide; Chlorpromazine; Ethanol; Methamphetamine; Motivation; Psychopharmacology; Rats; Research; Reward	1965
[APROPOS OF THE USE OF THE AMYTAL-CAFFEINE DISINHIBITION IN CHRONIC SCHIZOPHRENIA IN PSYCHOPATHOLOGICAL STUDY AND PROGNOSTIC EVALUATION OF THERAPY]. Voprosy psikhiatrii i nevropatologii; sbornik trudov, 1964, Volume: 10 Topics: Amobarbital; Caffeine; Humans; Mental Disorders; Prognosis; Psychopathology; Schizophrenia	1964
[COMBINED PARENTERAL USE OF BARBAMYL AND CAFFEINE IN MODERN PSYCHIATRIC THERAPY]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1965, Volume: 65 Topics: Amobarbital; Caffeine; Humans; Mental Disorders; Psychotherapy	1965