ammonium hydroxide and carbamyl phosphate

ammonium hydroxide has been researched along with carbamyl phosphate in 44 studies

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-199022 (50.00)18.7374
1990's9 (20.45)18.2507
2000's4 (9.09)29.6817
2010's7 (15.91)24.3611
2020's2 (4.55)2.80

Authors

AuthorsStudies
Grisolia, S; Rubio, V1
Mortenson, LE1
Bolivar, F; Galván, M; Martuscelli, J1
Alfant, M; Crandall, DE; Knott, CE; Tremblay, GS1
Aitken, DM; Kaplan, JG; Lue, PF1
Jernigan, HM; Kraus, AP; Kraus, LM; Schrank, GD1
Halliday, D; Hems, R; Krebs, HA; Lund, P; Read, WW1
Chappell, JB; McGivan, JD; Mourão, JM1
Elliott, BB; Mortenson, LE1
Milner, JA; Visek, WJ1
Krebs, HA1
Visek, WJ1
Chaparian, MG; Evans, DR1
Böger, P; Ernst, A; Reich, S1
Coleman, AE; Cooper, AJ; Filc-DeRicco, S; Gelbard, AS; Nieves, E1
Helber, JT; Hirschberg, R; Johnson, TR; Yarbrough, LR1
Lusty, CJ; Nyunoya, H; Rubino, SD2
Abdelal, AT; Bibb, WF; Nainan, O1
Meijer, AJ; Van Roermund, CW; Wanders, RJ1
Mazzocchi, RA; Spector, EB1
Colombo, JP1
Batshaw, ML; Brusilow, SW; Walser, M1
Akaboshi, I; Katsuki, T; Matsuda, I; Nagata, N; Ohtsuka, H; Yamamoto, J1
Rajantie, J1
Gustafson, LA; Meijer, AJ; Romp, N; van Woerkom, GM1
Deshmukh, DR; Ghole, VS; Nelson, J; Qureshi, IA1
Wu, G1
Britton, HG; Llorente, P; Rubio, V1
Evans, DR; Guy, HI; Liu, X; Sahay, N1
Brosnan, JT; Brosnan, ME; Nissim, I; Yudkoff, M1
Huang, X; Raushel, FM1
Bush, JA; Davis, TA; Nguyen, HV; Suryawan, A; Wu, G1
Kim, J; Raushel, FM1
Alberty, RA1
Evans, DR; Guy-Evans, H; Kibédi-Szabó, CZ; Perera, N; Popa, E; Purcarea, C1
Cervera, J; de Cima, S; Díez-Fernández, C; Fita, I; Martínez, AI; Polo, LM; Rubio, V1
Astrup, A; Carayol, J; Charon, C; Fazelzadeh, P; Hager, J; Lefebvre, G; Matone, A; Morine, M; Saris, WH; Scott-Boyer, MP; Valsesia, A; Vervoort, J1
Bezwada, D; Byers, LA; Cai, L; Castrillon, DH; Chen, BPC; Choi, E; DeBerardinis, RJ; Faubert, B; Girard, L; Heymach, JV; Hu, Z; Huffman, KE; Kim, J; Lambrechts, D; Li, K; Lin, YF; Minna, JD; Ni, M; Peña, CG; Rodriguez-Canales, J; Unsal-Kacmaz, K; Vansteenkiste, J; Villalobos, P; Wauters, E; Wistuba, I; Xu, J1
Fernie, AR; Joshi, V1
Alissandratos, A; Bartkus, DM; Easton, CJ; Fazelinejad, S; Hennessy, JE; Kim, HK; Latter, MJ; Oakeshott, JG; Onagi, H; Philbrook, A; Scott, C1
Borzone, R; Brunetti-Pierri, N; Hermann, K; Khoja, S; Lipshutz, GS; Ng, P; Nitzahn, M; Palmer, DJ; Rudd, M; Truong, B; Willis, B1
Guo, W; Jiang, Z; Luo, Y; Wang, L; Wei, C; Xiao, Y; Yuan, X1
Gao, F; Li, Z; Lu, Y; Zhang, L; Zou, Y1

Reviews

4 review(s) available for ammonium hydroxide and carbamyl phosphate

ArticleYear
Regulation of nitrogen fixation.
    Current topics in cellular regulation, 1978, Volume: 13

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Ammonia; Carbamyl Phosphate; Chromosome Mapping; Electron Transport; Glutamate-Ammonia Ligase; Hydrogen; Iron; Magnesium; Molybdenum; Mutation; Nitrogen Fixation; Nitrogenase; Oxygen

1978
Some regulatory aspects of urea synthesis.
    Enzyme, 1981, Volume: 26, Issue:5

    Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Carbamyl Phosphate; Citric Acid Cycle; Dietary Proteins; Female; Glutamates; Humans; Male; Ornithine; Proteins; Urea

1981
Citrulline metabolism in plants.
    Amino acids, 2017, Volume: 49, Issue:9

    Topics: Adaptation, Physiological; Amino Acid Transport Systems; Ammonia; Animals; Arabidopsis; Argininosuccinate Synthase; Bacteria; Biological Transport; Carbamyl Phosphate; Citrulline; Cucurbitaceae; Fungi; Gene Expression Regulation, Plant; Humans; Ornithine; Ornithine Carbamoyltransferase; Stress, Physiological

2017
Unraveling the therapeutic potential of carbamoyl phosphate synthetase 1 (CPS1) in human diseases.
    Bioorganic chemistry, 2023, Volume: 130

    Topics: Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl Phosphate; Humans; Mammals; Urea

2023

Trials

1 trial(s) available for ammonium hydroxide and carbamyl phosphate

ArticleYear
Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance.
    PloS one, 2016, Volume: 11, Issue:3

    Topics: Adult; Ammonia; Betaine; Caloric Restriction; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Chromosome Mapping; Female; Gene Expression; Gene Regulatory Networks; Genome-Wide Association Study; Glycine; Humans; Insulin Resistance; Lipid Metabolism; Male; Metabolome; Mitochondria; Obesity; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Urea; Weight Loss

2016

Other Studies

39 other study(ies) available for ammonium hydroxide and carbamyl phosphate

ArticleYear
Mechanism of mitochondrial carbamoyl-phosphate synthetase: synthesis and properties of active CO2, precursor of carbamoyl phosphate.
    Biochemistry, 1977, Jan-25, Volume: 16, Issue:2

    Topics: Acetone; Adenine Nucleotides; Ammonia; Animals; Anura; Bicarbonates; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Carbon Dioxide; Chemical Phenomena; Chemistry; Glutamates; Hydrogen-Ion Concentration; Kinetics; Magnesium; Mitochondria, Liver; Models, Biological; Phosphates; Phosphotransferases; Rana catesbeiana

1977
Biochemical and genetic characterization of a carbamyl phosphate synthetase mutant of Escherichia coli K12.
    Journal of general microbiology, 1976, Volume: 94, Issue:1

    Topics: Ammonia; Arginine; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbamyl Phosphate; Cell-Free System; Coliphages; Escherichia coli; Genes, Recessive; Glutamine; Mutagens; Mutation; Nitrosoguanidines; Ornithine; Ornithine Carbamoyltransferase; Phosphotransferases; Transduction, Genetic; Uracil Nucleotides

1976
Orotic acid biosynthesis in rat liver: studies on the source of carbamoylphosphate.
    Archives of biochemistry and biophysics, 1977, Jan-15, Volume: 178, Issue:1

    Topics: Ammonia; Ammonium Chloride; Animals; Bicarbonates; Carbamates; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Carbon Radioisotopes; Glutamine; Liver; Mitochondria, Liver; Ornithine; Orotic Acid; Phosphotransferases; Putrescine; Rats

1977
Kinetics and reaction mechanism of the carbamylphosphate synthetase of a multienzyme aggregate from yeast.
    Canadian journal of biochemistry, 1975, Volume: 53, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Ammonia; Bicarbonates; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbamyl Phosphate; Dose-Response Relationship, Drug; Enzyme Activation; Glutamine; Hydrogen-Ion Concentration; Kinetics; Magnesium; Models, Chemical; Multienzyme Complexes; Phosphotransferases; Potassium; Saccharomyces cerevisiae; Uracil Nucleotides; Xanthines

1975
Antisickling agents: effects of carbamyl phosphate or cyanate on survival, erythrocytes, and leucocytes in the mouse.
    American journal of hematology, 1979, Volume: 6, Issue:4

    Topics: Ammonia; Animals; Carbamates; Carbamyl Phosphate; Cyanates; Erythrocyte Count; Erythrocytes; Female; Hematocrit; Hemoglobins; Leukocyte Count; Leukocytes; Male; Mice; Sodium Chloride

1979
Sources of ammonia for mammalian urea synthesis.
    The Biochemical journal, 1978, Dec-15, Volume: 176, Issue:3

    Topics: Adenine Nucleotides; Alanine; Ammonia; Animals; Carbamyl Phosphate; In Vitro Techniques; Leucine; Liver; Rats; Urea

1978
The effects L-leucine on the synthesis of urea, glutamate and glutamine by isolated rat liver cells.
    The Biochemical journal, 1975, Volume: 146, Issue:2

    Topics: Alanine; Ammonia; Animals; Carbamyl Phosphate; Cell Separation; Female; Glutamate Dehydrogenase; Glutamates; Glutamine; Haplorhini; Leucine; Liver; Male; Mitochondria; Urea

1975
Regulation of molybdate transport by Clostridium pasteurianum.
    Journal of bacteriology, 1976, Volume: 127, Issue:2

    Topics: Acetylene; Ammonia; Biological Transport, Active; Carbamyl Phosphate; Chloramphenicol; Clostridium; Molybdenum; Nitrogen Fixation; Nitrogenase; Oxidation-Reduction

1976
Urinary metabolites characteristic of urea-cycle amino acid deficiency.
    Metabolism: clinical and experimental, 1975, Volume: 24, Issue:5

    Topics: Amino Acids; Amino Acids, Essential; Ammonia; Animal Nutritional Physiological Phenomena; Animals; Arginine; Biotransformation; Body Weight; Carbamyl Phosphate; Citrates; Citrulline; Deficiency Diseases; Diet; Male; Nitrogen; Ornithine; Orotic Acid; Pyrimidines; Rats; Urea

1975
The role of chemical equilibria in organ function.
    Advances in enzyme regulation, 1975, Volume: 13

    Topics: Alanine; Amino Acids; Ammonia; Animals; Aspartic Acid; Carbamyl Phosphate; Female; Glutamate Dehydrogenase; Glutaminase; Glutamine; Humans; Kidney; Metabolism; Rats; Thermodynamics; Transaminases; Urea

1975
Nitrogen-stimulated orotic acid synthesis and nucleotide imbalance.
    Cancer research, 1992, Apr-01, Volume: 52, Issue:7 Suppl

    Topics: Ammonia; Animals; Carbamyl Phosphate; Cattle; Humans; Liver Neoplasms; Milk; Orotic Acid; Pyrimidines; Rats; Triglycerides; Urea

1992
The catalytic mechanism of the amidotransferase domain of the Syrian hamster multifunctional protein CAD. Evidence for a CAD-glutamyl covalent intermediate in the formation of carbamyl phosphate.
    The Journal of biological chemistry, 1991, Feb-25, Volume: 266, Issue:6

    Topics: Ammonia; Animals; Anthranilate Synthase; Aspartate Carbamoyltransferase; Binding Sites; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbamyl Phosphate; Catalysis; Cricetinae; Dihydroorotase; Esters; Glutamine; Hydrolysis; Kinetics; Mesocricetus; Multienzyme Complexes; Nitrogenous Group Transferases; Sulfhydryl Compounds; Transferases

1991
Modification of dinitrogenase reductase in the cyanobacterium Anabaena variabilis due to C starvation and ammonia.
    Journal of bacteriology, 1990, Volume: 172, Issue:2

    Topics: Aerobiosis; Ammonia; Anaerobiosis; Carbamyl Phosphate; Carbon Dioxide; Cyanobacteria; Darkness; Dinitrogenase Reductase; Diuron; Ferredoxins; Fructose; Kinetics; Light; Potassium Cyanide

1990
Short-term metabolic fate of [13N]ammonia in rat liver in vivo.
    The Journal of biological chemistry, 1987, Jan-25, Volume: 262, Issue:3

    Topics: Alanine Transaminase; Amino Acids; Ammonia; Animals; Aspartate Aminotransferases; Carbamyl Phosphate; Chromatography, High Pressure Liquid; Citrulline; Cytoplasm; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Hepatic Veins; Kinetics; Liver; Male; Mitochondria, Liver; Portal Vein; Rats; Rats, Inbred Strains; Urea

1987
Effect of nitrogenous compounds on nitrogenase gene expression in anaerobic cultures of Anabaena variabilis.
    Journal of bacteriology, 1988, Volume: 170, Issue:2

    Topics: Ammonia; Anaerobiosis; Carbamyl Phosphate; Cyanobacteria; Gene Expression Regulation; Genes, Bacterial; Glutamates; Glutamine; Methionine Sulfoximine; Nitrates; Nitrogen; Nitrogen Fixation; Nitrogenase; Nucleic Acid Hybridization; RNA, Messenger; Transcription, Genetic

1988
Catalytic domains of carbamyl phosphate synthetase. Glutamine-hydrolyzing site of Escherichia coli carbamyl phosphate synthetase.
    The Journal of biological chemistry, 1986, Aug-25, Volume: 261, Issue:24

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Sequence; Ammonia; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Cysteine; Escherichia coli; Glutamine; Glycine; Hydrogen-Ion Concentration; Kinetics; Ligases; Mutation; Structure-Activity Relationship

1986
In vivo synthesis of carbamyl phosphate from NH3 by the large subunit of Escherichia coli carbamyl phosphate synthetase.
    The Journal of biological chemistry, 1987, Mar-25, Volume: 262, Issue:9

    Topics: Adenosine Triphosphate; Ammonia; Bicarbonates; Carbamates; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbamyl Phosphate; DNA, Recombinant; Escherichia coli; Genes, Bacterial; Kinetics; Ligases; Mutation; Plasmids; Recombinant Proteins; Transformation, Bacterial

1987
Carbamate kinase from Pseudomonas aeruginosa: purification, characterization, physiological role, and regulation.
    Journal of bacteriology, 1982, Volume: 151, Issue:3

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Ammonia; Anaerobiosis; Arginine; Carbamyl Phosphate; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; Organophosphates; Phosphotransferases; Phosphotransferases (Carboxyl Group Acceptor); Pseudomonas aeruginosa

1982
Analysis of the control of citrulline synthesis in isolated rat-liver mitochondria.
    European journal of biochemistry, 1984, Jul-16, Volume: 142, Issue:2

    Topics: Acetazolamide; Ammonia; Animals; Bicarbonates; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Citrulline; Male; Mitochondria, Liver; Ornithine; Ornithine Carbamoyltransferase; Rats; Rats, Inbred Strains; Valine

1984
The sparse fur mouse: an animal model for a human inborn error of metabolism of the urea cycle.
    Progress in clinical and biological research, 1983, Volume: 127

    Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Carbamyl Phosphate; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Mutant Strains; Ornithine Carbamoyltransferase Deficiency Disease; Purines; Pyrimidines; Urea

1983
Plasma alpha-ketoglutarate in urea cycle enzymopathies and its role as a harbinger of hyperammonemic coma.
    Pediatric research, 1980, Volume: 14, Issue:12

    Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Argininosuccinate Synthase; Argininosuccinic Acid; Argininosuccinic Aciduria; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Child; Child, Preschool; Coma; Female; Hepatic Encephalopathy; Humans; Infant; Infant, Newborn; Ketoglutaric Acids; Ligases; Lyases; Male; Middle Aged; Ornithine; Ornithine Carbamoyltransferase Deficiency Disease

1980
Ornithine transcarbamylase (OTC) in white blood cells.
    Pediatric research, 1980, Volume: 14, Issue:12

    Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Carbamyl Phosphate; Carbon Radioisotopes; Cattle; Cells, Cultured; Humans; Infant; Leukocytes; Liver; Ornithine; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Radioligand Assay

1980
Orotic aciduria in lysinuric protein intolerance: dependence on the urea cycle intermediates.
    Pediatric research, 1981, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Alanine; Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Carbamyl Phosphate; Child; Child, Preschool; Female; Heterozygote; Homozygote; Humans; Infant; Male; Orotic Acid; Proteins; Rats; Urea

1981
Carbamoyl phosphate and ureagenesis are not involved in amino-acid-stimulated glycogenesis.
    European journal of biochemistry, 1994, Jul-15, Volume: 223, Issue:2

    Topics: Amino Acids; Ammonia; Animals; Carbamyl Phosphate; Cells, Cultured; Glucose; Glycogen; Hypotonic Solutions; Liver; Male; Ornithine; Phosphorylation; Picolinic Acids; Rats; Rats, Wistar; Urea

1994
Regulation of orotic acid biosynthesis and excretion induced by oral glutamine administration in mice.
    Biochemical medicine and metabolic biology, 1993, Volume: 49, Issue:3

    Topics: Administration, Oral; Ammonia; Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbamyl Phosphate; Cycloheximide; Glutamine; Isoxazoles; Male; Mice; Mice, Inbred ICR; Mitochondria, Liver; Ornithine Decarboxylase; Ornithine-Oxo-Acid Transaminase; Orotic Acid

1993
Urea synthesis in enterocytes of developing pigs.
    The Biochemical journal, 1995, Dec-15, Volume: 312 ( Pt 3)

    Topics: Ammonia; Ammonium Chloride; Animals; Animals, Newborn; Animals, Suckling; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Chromatography, High Pressure Liquid; Citrulline; Glutamine; Intestinal Mucosa; Intestines; Ornithine; Ornithine Carbamoyltransferase; Swine; Urea; Weaning

1995
Mechanism of carbamoyl phosphate synthetase from Escherichia coli--binding of the ATP molecules used in the reaction and sequestration by the enzyme of the ATP molecule that yields carbamoyl phosphate.
    European journal of biochemistry, 1998, Jul-01, Volume: 255, Issue:1

    Topics: Adenosine Triphosphate; Ammonia; Bicarbonates; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbamyl Phosphate; Cations, Monovalent; Escherichia coli; Glutamine; Models, Chemical; Ornithine; Phosphates; Potassium

1998
Regulation of an Escherichia coli/mammalian chimeric carbamoyl-phosphate synthetase.
    The Journal of biological chemistry, 1998, Nov-20, Volume: 273, Issue:47

    Topics: Adenosine Triphosphate; Allosteric Regulation; Ammonia; Animals; Bicarbonates; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbamyl Phosphate; Escherichia coli; Glutamine; Ligands; Mammals; Models, Molecular; Mutation; Phosphoribosyl Pyrophosphate; Recombinant Fusion Proteins; Sequence Deletion

1998
Studies of hepatic glutamine metabolism in the perfused rat liver with (15)N-labeled glutamine.
    The Journal of biological chemistry, 1999, Oct-08, Volume: 274, Issue:41

    Topics: Ammonia; Animals; Aspartic Acid; Carbamyl Phosphate; Citrulline; Glucagon; Glutamates; Glutaminase; Glutamine; Insulin; Liver; Male; Nitrogen Isotopes; Oxygen Consumption; Perfusion; Rats; Rats, Sprague-Dawley; Urea

1999
An engineered blockage within the ammonia tunnel of carbamoyl phosphate synthetase prevents the use of glutamine as a substrate but not ammonia.
    Biochemistry, 2000, Mar-28, Volume: 39, Issue:12

    Topics: Alanine; Ammonia; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbamyl Phosphate; Escherichia coli; Glutamic Acid; Glutamine; Glycine; Kinetics; Lysine; Methionine; Mutagenesis, Site-Directed; Phenylalanine; Serine; Substrate Specificity; Time Factors

2000
Somatotropin-induced amino acid conservation in pigs involves differential regulation of liver and gut urea cycle enzyme activity.
    The Journal of nutrition, 2002, Volume: 132, Issue:1

    Topics: Amino Acids; Ammonia; Animals; Bicarbonates; Blood Urea Nitrogen; Body Weight; Breath Tests; Carbamyl Phosphate; Carbon Isotopes; Female; Glutamates; Growth Hormone; Jejunum; Liver; Nitrogen; Oxidation-Reduction; Phenylalanine; Random Allocation; Substrate Specificity; Swine; Urea

2002
Perforation of the tunnel wall in carbamoyl phosphate synthetase derails the passage of ammonia between sequential active sites.
    Biochemistry, 2004, May-11, Volume: 43, Issue:18

    Topics: Alanine; Ammonia; Arginine; Binding Sites; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Computer Simulation; Escherichia coli Proteins; Glutamine; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Secondary; Protein Subunits

2004
Thermodynamics of the reactions of carbamoyl phosphate.
    Archives of biochemistry and biophysics, 2006, Jul-01, Volume: 451, Issue:1

    Topics: Ammonia; Bicarbonates; Carbamates; Carbamyl Phosphate; Carbon Dioxide; Catalysis; Hydrogen-Ion Concentration; Kinetics; Mathematical Computing; Models, Chemical; Osmolar Concentration; Phosphotransferases (Carboxyl Group Acceptor); Thermodynamics

2006
The smallest active carbamoyl phosphate synthetase was identified in the human gut archaeon Methanobrevibacter smithii.
    Journal of molecular microbiology and biotechnology, 2012, Volume: 22, Issue:5

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Ammonia; Archaeal Proteins; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Catalytic Domain; Chromatography, Gel; Cloning, Molecular; Enzyme Activation; Escherichia coli; Gastrointestinal Tract; Genes, Archaeal; Humans; Methanobrevibacter; Models, Molecular; Molecular Sequence Data; Phosphorylation; Phylogeny; Protein Conformation; Protein Structure, Tertiary; Recombinant Proteins; Sequence Analysis, Protein; Species Specificity

2012
Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.
    Scientific reports, 2015, Nov-23, Volume: 5

    Topics: Amino Acid Motifs; Ammonia; Animals; Baculoviridae; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl Phosphate; Cloning, Molecular; Crystallography, X-Ray; Gene Expression; Glutamates; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Phosphorylation; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Sf9 Cells; Spodoptera; Substrate Specificity; Urea

2015
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
    Nature, 2017, 06-01, Volume: 546, Issue:7656

    Topics: Ammonia; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Bicarbonates; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Proliferation; DNA; DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; Female; Gene Silencing; Humans; Lung Neoplasms; Male; Metabolomics; Mice; Mitochondria; Nitrogen; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins p21(ras); Purines; Pyrimidines; S Phase; Transcription, Genetic; Xenograft Model Antitumor Assays

2017
Hyperthermophilic Carbamate Kinase Stability and Anabolic
    Applied and environmental microbiology, 2018, 02-01, Volume: 84, Issue:3

    Topics: Alkalies; Ammonia; Anabolic Agents; Carbamates; Carbamyl Phosphate; Catalysis; Clostridium tetani; Enterococcus faecalis; Enzyme Stability; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Phosphotransferases (Carboxyl Group Acceptor); Protein Conformation; Pyrococcus furiosus; Temperature; Thermococcus

2018
Conditional disruption of hepatic carbamoyl phosphate synthetase 1 in mice results in hyperammonemia without orotic aciduria and can be corrected by liver-directed gene therapy.
    Molecular genetics and metabolism, 2018, Volume: 124, Issue:4

    Topics: Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl Phosphate; Female; Gene Expression Regulation, Enzymologic; Genetic Therapy; Glutamine; Humans; Hyperammonemia; Liver; Male; Mice; Mice, Knockout; Mutation; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Purine-Pyrimidine Metabolism, Inborn Errors

2018
Ornithine aminotransferase and carbamoyl phosphate synthetase 1 involved in ammonia metabolism serve as novel targets for early stages of gastric cancer.
    Journal of clinical laboratory analysis, 2022, Volume: 36, Issue:10

    Topics: Ammonia; Antineoplastic Agents; Biomarkers; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Humans; Ornithine-Oxo-Acid Transaminase; Stomach Neoplasms; Tandem Mass Spectrometry

2022