amlodipine has been researched along with simvastatin in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (31.71) | 29.6817 |
| 2010's | 24 (58.54) | 24.3611 |
| 2020's | 4 (9.76) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Beaumont, K; Di, L; Maurer, TS; Smith, DA | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Forfia, PR; Hintze, TH; Liao, J; Loke, KE; Magneson, A; Mital, S | 1 |
| Vita, JA; Winniford, M; Yeung, AC | 1 |
| Adler, S; Gupta, S; Hintze, TH; Huang, H; Trochu, JN; Xu, X | 1 |
| Echizen, H; Hiraga, M; Ida, T; Oishi, K; Uchida, MK; Yamaguchi, T | 1 |
| Hayashi, H; Kosuge, K; Nishio, S; Ohashi, K; Uchida, S; Watanabe, H | 1 |
| Chiou, SY; Lai, GW; Lin, G; Lin, LY | 1 |
| Bartuś, S; Bryniarski, L; Dobrowolski, W; Dudek, D; Giszterowicz, D; Korpak-Wysocka, R; Kukla, P | 1 |
| Doggrell, SA | 1 |
| Sundermeyer, M; Veeraputhiran, M | 1 |
| Mullangi, R; Ramani, AV; Sengupta, P | 1 |
| Choi, JW; Kim, SH; Lee, H; Lee, SJ; Lim, HE; Park, CG | 1 |
| Wald, DS; Wald, NJ | 1 |
| Balink, H; de Graaf, W; Grond, J; Hemmelder, MH | 1 |
| Bolen, MA; Halliburton, SS; Schoenhagen, P | 1 |
| Derosa, G; Fogari, R; Lazzari, P; Maffioli, P; Mugellini, A; Zoppi, A | 1 |
| Morris, JK; Wald, DS; Wald, NJ | 1 |
| Cvetković, Z; Nešković, A; Panić, M; Suvajdžić-Vuković, N; Todorović, Z | 1 |
| Jang, SB; Lee, D; Lim, LA; Park, K; Roh, H; Son, H | 1 |
| Chaturvedula, A; Lee, H; Sale, ME | 1 |
| Ahmed, FR; Khan, MA; Manzoor, S; Nasiri, MI; Salam, FA; Shoaib, MH; Sultan, F; Yousuf, RI | 1 |
| Lindelof, M; Skovbølling, SL | 1 |
| Ghushchyan, V; Nair, K; Saseen, JJ; Tuchscherer, RM | 1 |
| Foerster, J; Schetz, D; Sein Anand, J | 1 |
| Luteijn, JM; Morris, JK; Oppenheimer, P; Taylor, D; Wald, NJ | 1 |
| Goltz, L; Knoth, H; Schröder, J | 1 |
| Buda, S; Degli Esposti, E; Degli Esposti, L; Sangiorgi, D; Scaglione, F | 1 |
| Agarwal, I; Ferket, BS; Fleischmann, KE; Hunink, MG; Khanji, M; Petersen, SE | 1 |
| Fuhrmann, S; Knoth, H; Koppen, A; Schröder, J; Seeling, A | 1 |
| Arancón-Monge, JM; Campos-Díaz, L; de Castro-Cuenca, A; Del Cura-González, I; Rodríguez Barrientos, R; Serrano-Vázquez, Á | 1 |
| Glick, A; Johnson, C; Sista, V | 1 |
| Kassie, GM; Kerr, M; Moffat, A; Pratt, N; Roughead, EE | 1 |
| Ahmad, S; Ali, N; Ali, W; Hussain, H; Ullah, A | 1 |
2 review(s) available for amlodipine and simvastatin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Is atorvastatin superior to other statins? Analysis of the clinical trials with atorvastatin having cardiovascular endpoints.
Topics: Amlodipine; Anticholesteremic Agents; Atorvastatin; Azetidines; Cardiovascular Diseases; Clinical Trials as Topic; Clofibric Acid; Ezetimibe; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Indoles; Pravastatin; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides | 2006 |
6 trial(s) available for amlodipine and simvastatin
| Article | Year |
|---|---|
Interaction between amlodipine and simvastatin in patients with hypercholesterolemia and hypertension.
Topics: Administration, Oral; Aged; Amlodipine; Antihypertensive Agents; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Male; Middle Aged; Prospective Studies; Simvastatin | 2005 |
Non-concurrent dosing attenuates the pharmacokinetic interaction between amlodipine and simvastatin.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Area Under Curve; Drug Administration Schedule; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypertension; Male; Middle Aged; Simvastatin | 2010 |
Effects of losartan and amlodipine alone or combined with simvastatin in hypertensive patients with nonalcoholic hepatic steatosis.
Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Body Mass Index; Body Weight; Double-Blind Method; Drug Therapy, Combination; Fatty Liver; Female; Glucose Clamp Technique; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Inflammation Mediators; Insulin Resistance; Lipids; Losartan; Male; Middle Aged; Simvastatin; Ultrasonography | 2012 |
Randomized Polypill crossover trial in people aged 50 and over.
Topics: Aged; Amlodipine; Anticholesteremic Agents; Antihypertensive Agents; Blood Pressure; Cardiovascular Diseases; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypercholesterolemia; Hypertension; Losartan; Male; Middle Aged; Placebos; Simvastatin | 2012 |
Development of a pharmacokinetic interaction model for co-administration of simvastatin and amlodipine.
Topics: Administration, Oral; Adult; Age Factors; Amlodipine; Biological Availability; Body Weight; Calcium Channel Blockers; Cross-Over Studies; Cytochrome P-450 CYP3A; Drug Interactions; Genotype; Healthy Volunteers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Models, Biological; Phenotype; Polymorphism, Genetic; Polypharmacy; Republic of Korea; Simvastatin | 2014 |
Genetic algorithm guided population pharmacokinetic model development for simvastatin, concurrently or non-concurrently co-administered with amlodipine.
Topics: Adult; Aged; Algorithms; Amlodipine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Models, Biological; Simvastatin | 2014 |
33 other study(ies) available for amlodipine and simvastatin
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Volume of Distribution in Drug Design.
Topics: Drug Design; Half-Life; Pharmacokinetics | 2015 |
Simvastatin acts synergistically with ACE inhibitors or amlodipine to decrease oxygen consumption in rat hearts.
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Calcium Channel Blockers; Drug Synergism; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Myocardium; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxygen Consumption; Penicillamine; Ramipril; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Simvastatin; Up-Regulation | 2000 |
Coronary artery reactivity after treatment with simvastatin.
Topics: Amlodipine; Bezafibrate; Coronary Angiography; Coronary Artery Disease; Coronary Disease; Coronary Vessels; Female; Humans; Male; Myocardial Infarction; Prognosis; Prospective Studies; Randomized Controlled Trials as Topic; Simvastatin; Survival Rate; Treatment Outcome | 2001 |
Simvastatin reverses impaired regulation of renal oxygen consumption in congestive heart failure.
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Dogs; Endothelium, Vascular; Heart Failure; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Kidney Cortex; Kidney Medulla; Male; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxygen Consumption; Penicillamine; Ramipril; Simvastatin; Ventricular Function, Left | 2001 |
[Effects of angiotensin II receptor blockers, angiotensin converting enzyme inhibitors, 3-hydroxy-3-methyl glutaryl (HMG) CoA reductase inhibitors, amlodipine and epalrestat on cultured basilar artery smooth muscle cell proliferation].
Topics: Amlodipine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arteriosclerosis; Basilar Artery; Calcium Channel Blockers; Cell Division; Cells, Cultured; Depression, Chemical; Fatty Acids, Monounsaturated; Fluvastatin; Guinea Pigs; Hydroxymethylglutaryl CoA Reductases; Indoles; Muscle, Smooth, Vascular; Oxidative Stress; Reactive Oxygen Species; Rhodanine; Simvastatin; Thiazolidines | 2004 |
Kinetics and mechanisms of cholesterol esterase inhibition by cardiovascular drugs in vitro.
Topics: Amlodipine; Cardiovascular Agents; Enzyme Inhibitors; Hydralazine; Kinetics; Nifedipine; Octoxynol; Simvastatin; Sterol Esterase; Taurocholic Acid | 2006 |
[Transient left ventricular apical ballooning syndrome--a case report].
Topics: Aged; Amlodipine; Echocardiography, Doppler; Electrocardiography; Enoxaparin; Female; Humans; Simvastatin; Syndrome; Treatment Outcome; Ventricular Dysfunction, Left | 2007 |
Rhabdomyolysis resulting from pharmacologic interaction between erlotinib and simvastatin.
Topics: Aged; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atenolol; Azetidines; Carcinoma, Non-Small-Cell Lung; Coronary Artery Disease; Drug Interactions; Erlotinib Hydrochloride; Ezetimibe; Female; Humans; Hyperlipidemias; Hypertension; Lung Neoplasms; Neoplasm Recurrence, Local; Protein Kinase Inhibitors; Quinazolines; Rhabdomyolysis; Simvastatin; Tomography, X-Ray Computed | 2008 |
Development and validation of a highly sensitive and robust LC-ESI-MS/MS method for simultaneous quantitation of simvastatin acid, amlodipine and valsartan in human plasma: application to a clinical pharmacokinetic study.
Topics: Acetonitriles; Amlodipine; Antihypertensive Agents; Chromatography, High Pressure Liquid; Humans; Male; Reproducibility of Results; Sensitivity and Specificity; Simvastatin; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tetrazoles; Time Factors; Valine; Valsartan | 2009 |
Implementation of a simple age-based strategy in the prevention of cardiovascular disease: the Polypill approach.
Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Bendroflumethiazide; Cardiovascular Diseases; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Patient Compliance; Primary Prevention; Risk Factors; Simvastatin | 2012 |
Scintigraphic diagnosis of Erdheim-Chester disease.
Topics: Aged; Amlodipine; Antihypertensive Agents; Diabetes Mellitus, Type 2; Drug Combinations; Erdheim-Chester Disease; Gated Blood-Pool Imaging; Humans; Hydrochlorothiazide; Hypoglycemic Agents; Hypolipidemic Agents; Imidazoles; Knee Joint; Losartan; Male; Metformin; Positron-Emission Tomography; Prostatic Neoplasms; Simvastatin | 2011 |
Iterative CT reconstruction of aortic intramural hematoma.
Topics: Amlodipine; Aortic Aneurysm; Aortic Dissection; Captopril; Drug Therapy, Combination; Female; Hematoma; Humans; Hydralazine; Metoprolol; Middle Aged; Multidetector Computed Tomography; Simvastatin; Treatment Outcome | 2011 |
Simvastatin and amlodipine induced thrombocytopenia in the same patient: double trouble and a literature review.
Topics: Aged; Amlodipine; Antihypertensive Agents; Female; Humans; Hypolipidemic Agents; Simvastatin; Thrombocytopenia | 2013 |
Simultaneous quantitation of aspirin, amlodipine and simvastatin in a fixed dose combination of encapsulated tablet formulation by HPLC-UV method.
Topics: Amlodipine; Aspirin; Cardiovascular Agents; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drug Combinations; Limit of Detection; Reproducibility of Results; Simvastatin; Spectrophotometry, Ultraviolet; Tablets; Technology, Pharmaceutical | 2014 |
[Myopathy and rhabdomyolysis after treatment with simvastatin, amlodipine, and roxithromycin].
Topics: Aged; Amlodipine; Anti-Bacterial Agents; Antihypertensive Agents; Drug Interactions; Humans; Hypertension; Male; Muscular Diseases; Rhabdomyolysis; Roxithromycin; Simvastatin | 2014 |
Simvastatin prescribing patterns before and after FDA dosing restrictions: a retrospective analysis of a large healthcare claims database.
Topics: Amlodipine; Calcium Channel Blockers; Comorbidity; Drug Interactions; Drug Labeling; Drug Prescriptions; Dyslipidemias; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Incidence; Insurance, Health; Male; Middle Aged; Muscular Diseases; Off-Label Use; Pharmacovigilance; Practice Patterns, Physicians'; Retrospective Studies; Risk Factors; Simvastatin; United States; United States Food and Drug Administration | 2015 |
[Drug interaction in 63-year-old male sportsman--a case report].
Topics: Amlodipine; Confusion; Dizziness; Drug Interactions; Exercise; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Myalgia; Simvastatin | 2015 |
Cost-benefit analysis of the polypill in the primary prevention of myocardial infarction and stroke.
Topics: Aged; Aged, 80 and over; Amlodipine; Aspirin; Cardiovascular Agents; Case-Control Studies; Cohort Studies; Cost-Benefit Analysis; Humans; Hydrochlorothiazide; Losartan; Markov Chains; Middle Aged; Myocardial Infarction; Polypharmacy; Primary Prevention; Quality-Adjusted Life Years; Simvastatin; Stroke; United Kingdom | 2016 |
[Medication management: Simvastatin and Amlodipin - a clinically relevant drug-interaction?]
Topics: Amlodipine; Anticholesteremic Agents; Antihypertensive Agents; Drug Interactions; Evidence-Based Medicine; Humans; Simvastatin; Treatment Outcome | 2016 |
Therapy discontinuation or substitution in patients with cardiovascular disease, switching among different products of the same off-patent active substance: a 'real-world' retrospective cohort study.
Topics: Aged; Amlodipine; Antihypertensive Agents; Cardiovascular Diseases; Databases, Factual; Drug Substitution; Drugs, Generic; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Italy; Male; Medication Adherence; Middle Aged; Multivariate Analysis; Ramipril; Retrospective Studies; Simvastatin | 2016 |
Cost-effectiveness of the polypill versus risk assessment for prevention of cardiovascular disease.
Topics: Administration, Oral; Adult; Aged; Amlodipine; Antihypertensive Agents; Cardiovascular Diseases; Computer Simulation; Cost-Benefit Analysis; Drug Combinations; Drug Costs; Dyslipidemias; Female; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Losartan; Male; Middle Aged; Models, Economic; Primary Prevention; Quality-Adjusted Life Years; Risk Assessment; Risk Factors; Simvastatin; Tablets; Time Factors; Treatment Outcome | 2017 |
Analysis of secondary care data to evaluate the clinical relevance of the drug-drug interaction between amlodipine and simvastatin.
Topics: Amlodipine; Area Under Curve; Biological Availability; Drug Administration Schedule; Drug Interactions; Germany; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Polypharmacy; Secondary Care; Simvastatin | 2019 |
[Effects of changing the appearance of medications in safety and adherence in chronic patients over 65 years of age in primary care. CAMBIMED Study].
Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Chronic Disease; Drug Labeling; Drug Packaging; Enalapril; Female; Follow-Up Studies; Humans; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Longitudinal Studies; Male; Medication Adherence; Medication Errors; Primary Health Care; Prospective Studies; Simvastatin | 2020 |
Oral Manifestations of Commonly Prescribed Drugs.
Topics: Albuterol; Amlodipine; Anticonvulsants; Antihypertensive Agents; Atorvastatin; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bronchodilator Agents; Deprescriptions; Drug Hypersensitivity; Fluorides; Gingival Overgrowth; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperpigmentation; Hypoglycemic Agents; Lisinopril; Losartan; Metformin; Metoprolol; Mouth Diseases; Omeprazole; Oral Hygiene; Proton Pump Inhibitors; Simvastatin; Thyroxine; Toothpastes; Xerostomia | 2020 |
Medicine-Induced Acute Kidney Injury Findings from Spontaneous Reporting Systems, Sequence Symmetry Analysis and a Case-Control Study with a Focus on Medicines Used in Primary Care.
Topics: Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Amlodipine; Amphotericin B; Australia; Case-Control Studies; Ciprofloxacin; Diclofenac; Furosemide; Humans; Ibuprofen; Metformin; Naproxen; Omeprazole; Primary Health Care; Ramipril; Simvastatin; Spironolactone; Sulfamethoxazole; Telmisartan; Trimethoprim; Valacyclovir; Zoledronic Acid | 2022 |
Rosuvastatin and Simvastatin potentiate antihypertensive effect of amlodipine through vasorelaxation phenomenon.
Topics: Amlodipine; Animals; Antihypertensive Agents; Rats; Rats, Wistar; Rosuvastatin Calcium; Simvastatin; Vasodilation; Vasodilator Agents | 2023 |