amlodipine and nicardipine

amlodipine has been researched along with nicardipine in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (5.41)	18.7374
1990's	7 (18.92)	18.2507
2000's	14 (37.84)	29.6817
2010's	14 (37.84)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Arrowsmith, JE; Blackburn, KJ; Burges, RA; Campbell, SF; Cross, PE; Gardiner, DG; Stubbs, JK	1
Topliss, JG; Yoshida, F	1
Katoh, M; Nakajima, M; Yamazaki, H; Yokoi, T	1
Bruno-Blanch, L; Gálvez, J; García-Domenech, R	1
Caron, G; Ermondi, G; Lorenti, M	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Reimão, JQ; Scotti, MT; Tempone, AG	1
Sun, H	1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Frais, MA; Jackson, N; Midtbo, KA; Reynolds, G; Sharma, S; Silke, B; Taylor, SH; Verma, SP	1
Chauvet-Monges, AM; Crevat, A; Salducci, MD; Tabouy, L	1
Bretnall, AE; Clarke, GS	1
White, CM	1
Seibold, JR; Sturgill, MG	1
Doğrul, A; Yeşilyurt, O	1
Christians, T; Diewald, D; Holzgrabe, U; Lehmann, J; Otte, Y; Wessler, C	1
Eraković, V; Kriz, J; Simonić, A; Varljen, J; Zupan, G	1
Fukuzawa, M; Miyaguchi, S; Nakazawa, T; Ohta, S; Qiang, X; Sakata, Y; Satoh, J; Takahashi, K; Takizawa, Y; Toyota, T	1
Araki, H; Futagami, K; Gomita, Y; Kawasaki, H; Kurosaki, Y; Nakatsuma, A	1
Bernaud, C; Carre, A; Clerson, P; Emeriau, JP; Jaboureck, O; Mounier-Véhier, C	1
Pope, J	1
Cadirci, E; Halici, Z; Suleyman, H	1
Chen, Y; Qi, L; Wei, X; Yang, G	1
An Haack, K; Bennett, MJ; Li, H; Narayan, SB; Tan, L; Warnock, A	1
Gordon, CJ; Hederman, AD; Herrington, B; Ostrenga, AR; Pierce, WA	1
Aladejebi, O; Hockerman, GH; Lin, M	1
Bernard, E; Bertrand, Y; Bleyzac, N; Goutelle, S	1
Iizuka, N; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Ushikubo, H	1
Abrams, RI; Baxi, PV; Herring, MJ; Korbet, SM; Lichtenstein, SJ	1
Kinjo, M; Raita, Y; Tsuchida, T; Yano, H	1

Reviews

3 review(s) available for amlodipine and nicardipine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Calcium channel blockers in left ventricular dysfunction or congestive heart failure. Connecticut medicine, 1997, Volume: 61, Issue:10 Topics: Amlodipine; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Felodipine; Heart Failure; Humans; Nicardipine; Nifedipine; Ventricular Dysfunction, Left; Verapamil	1997
Raynaud's phenomenon (primary). Clinical evidence, 2003, Issue:9 Topics: Amlodipine; Diltiazem; Humans; Nafronyl; Nicardipine; Nifedipine; Raynaud Disease; Vasodilator Agents	2003

Trials

2 trial(s) available for amlodipine and nicardipine

Article	Year
Comparative hemodynamic dose-response effects of five slow calcium channel-blocking agents in coronary artery disease. Clinical pharmacology and therapeutics, 1987, Volume: 42, Issue:4 Topics: Amlodipine; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Diltiazem; Dose-Response Relationship, Drug; Female; Hemodynamics; Humans; Male; Middle Aged; Nicardipine; Nifedipine; Nisoldipine; Prospective Studies; Random Allocation; Verapamil	1987
Randomized, comparative, double-blind study of amlodipine vs. nicardipine as a treatment of isolated systolic hypertension in the elderly. Fundamental & clinical pharmacology, 2002, Volume: 16, Issue:6 Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypertension; Male; Nicardipine; Patient Compliance; Time Factors	2002

Article

Year

Comparative hemodynamic dose-response effects of five slow calcium channel-blocking agents in coronary artery disease.

Clinical pharmacology and therapeutics, 1987, Volume: 42, Issue:4

Topics: Amlodipine; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Diltiazem; Dose-Response Relationship, Drug; Female; Hemodynamics; Humans; Male; Middle Aged; Nicardipine; Nifedipine; Nisoldipine; Prospective Studies; Random Allocation; Verapamil

1987

Randomized, comparative, double-blind study of amlodipine vs. nicardipine as a treatment of isolated systolic hypertension in the elderly.

Fundamental & clinical pharmacology, 2002, Volume: 16, Issue:6

Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypertension; Male; Nicardipine; Patient Compliance; Time Factors

2002

Other Studies

32 other study(ies) available for amlodipine and nicardipine

Article	Year
Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents. Journal of medicinal chemistry, 1986, Volume: 29, Issue:9 Topics: Amlodipine; Animals; Biological Assay; Biological Availability; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Dihydropyridines; Dogs; Guinea Pigs; Hemodynamics; Kinetics; Male; Nifedipine; Pyridines; Rats; Vasoconstriction	1986
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4. Pharmaceutical research, 2000, Volume: 17, Issue:10 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Daunorubicin; Digoxin; Dihydropyridines; Humans; Mixed Function Oxygenases; Substrate Specificity; Transfection; Tritium	2000
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship	2003
Contribution of ionization and lipophilicity to drug binding to albumin: a preliminary step toward biodistribution prediction. Journal of medicinal chemistry, 2004, Jul-29, Volume: 47, Issue:16 Topics: Chromatography, Affinity; Hydrogen-Ion Concentration; Ions; Models, Molecular; Molecular Conformation; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin, Bovine; Ultracentrifugation	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure-activity relationship study. Bioorganic & medicinal chemistry, 2010, Nov-15, Volume: 18, Issue:22 Topics: Animals; Antiprotozoal Agents; Cell Line; Cricetinae; Dihydropyridines; Erythrocytes; Leishmania; Macaca mulatta; Mice; Parasitic Sensitivity Tests; Quantitative Structure-Activity Relationship; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi	2010
Capture hydrolysis signals in the microsomal stability assay: molecular mechanisms of the alkyl ester drug and prodrug metabolism. Bioorganic & medicinal chemistry letters, 2012, Jan-15, Volume: 22, Issue:2 Topics: Carboxylic Acids; Cytochrome P-450 Enzyme System; Esters; Humans; Hydrolysis; Microsomes; Models, Molecular; Molecular Structure; Prodrugs; Quantum Theory; Signal Transduction	2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10 Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Protective effect of some calcium antagonists against mitochondrial calcium injury. International journal of tissue reactions, 1994, Volume: 16, Issue:5-6 Topics: Adenosine Triphosphate; Amlodipine; Animals; Antihypertensive Agents; Bepridil; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Male; Mitochondria, Liver; Myocardial Ischemia; Nicardipine; Rats; Rats, Wistar; Verapamil	1994
Investigation and optimisation of the use of micellar electrokinetic chromatography for the analysis of six cardiovascular drugs. Journal of chromatography. A, 1995, May-12, Volume: 700, Issue:1-2 Topics: Amlodipine; Atenolol; Cardiovascular Agents; Chromatography; Diltiazem; Electrochemistry; Hydrogen-Ion Concentration; Kinetics; Micelles; Nicardipine; Nifedipine; Osmosis; Sodium Dodecyl Sulfate; Verapamil	1995
Rational use of calcium-channel antagonists in Raynaud's phenomenon. Current opinion in rheumatology, 1998, Volume: 10, Issue:6 Topics: Amlodipine; Calcium Channel Blockers; Diltiazem; Felodipine; Humans; Isradipine; Nicardipine; Nifedipine; Raynaud Disease	1998
Effects of Ca2+ channel blockers on apomorphine, bromocriptine and morphine-induced locomotor activity in mice. European journal of pharmacology, 1999, Jan-08, Volume: 364, Issue:2-3 Topics: Amlodipine; Animals; Apomorphine; Benzazepines; Bromocriptine; Calcium Channel Blockers; Diltiazem; Dopamine Antagonists; Female; Haloperidol; Heterocyclic Compounds, 4 or More Rings; Mice; Morphine; Motor Activity; Nicardipine; Time Factors; Verapamil	1999
Resolution of newly synthesized racemic dihydropyridines with different chiral selectors by means of capillary electrophoresis. Journal of chromatography. A, 1999, Aug-20, Volume: 853, Issue:1-2 Topics: Amlodipine; Calcium Channel Blockers; Cyclodextrins; Dihydropyridines; Electrophoresis, Capillary; Nicardipine; Stereoisomerism	1999
The influence of nimodipine, nicardipine and amlodipine on the brain free fatty acid level in rats with penicillin-induced seizures. Progress in neuro-psychopharmacology & biological psychiatry, 1999, Volume: 23, Issue:5 Topics: Amlodipine; Animals; Brain Chemistry; Calcium Channel Blockers; Calcium Channels, L-Type; Fatty Acids, Nonesterified; Male; Nicardipine; Nimodipine; Penicillins; Rats; Rats, Wistar; Seizures	1999
Modulation of tumor necrosis factor-alpha production with anti-hypertensive drugs. Immunopharmacology, 2000, Volume: 48, Issue:1 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amlodipine; Animals; Antihypertensive Agents; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Diuretics; Doxazosin; Humans; Hydrochlorothiazide; Interleukin-1; Interleukin-6; Lipopolysaccharides; Male; Metoprolol; Mice; Mice, Inbred BALB C; Monocytes; Nicardipine; Nitrobenzenes; Piperazines; Sodium Chloride Symporter Inhibitors; Tumor Necrosis Factor-alpha	2000
Effects of long-term treatment with calcium antagonists on periarterial nerve function in the mesenteric artery of spontaneously hypertensive rats. Japanese journal of pharmacology, 2000, Volume: 84, Issue:2 Topics: Amlodipine; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Drug Interactions; Hypertension; Male; Mesenteric Arteries; Nervous System; Nicardipine; Norepinephrine; Rats; Rats, Inbred SHR; Vasoconstrictor Agents; Vasodilator Agents	2000
Effects of calcium channel blockers on hyaluronidase-induced capillary vascular permeability. Archives of pharmacal research, 2008, Volume: 31, Issue:7 Topics: Amlodipine; Animals; Calcium Channel Blockers; Capillary Permeability; Carrageenan; Dihydropyridines; Hyaluronoglucosaminidase; Inflammation; Injections, Intravenous; Male; Nicardipine; Rats; Rats, Wistar	2008
Determination of nicardipine and amlodipine in human plasma using on-line solid-phase extraction with a monolithic weak cation-exchange column. Talanta, 2009, Jan-15, Volume: 77, Issue:3 Topics: Amlodipine; Calibration; Cations; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Hydrogen-Ion Concentration; Molecular Structure; Nicardipine; Online Systems; Quinidine; Serum Albumin; Solid Phase Extraction	2009
Screening for calcium channel modulators in CLN3 siRNA knock down SH-SY5Y neuroblastoma cells reveals a significant decrease of intracellular calcium levels by selected L-type calcium channel blockers. Biochimica et biophysica acta, 2011, Volume: 1810, Issue:2 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amlodipine; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line, Tumor; Child; Drug Evaluation, Preclinical; Flunarizine; Humans; Intracellular Space; Membrane Glycoproteins; Molecular Chaperones; Neuroblastoma; Neuronal Ceroid-Lipofuscinoses; Nicardipine; Nifedipine; Nimodipine; Potassium Chloride; RNA Interference; RNA, Small Interfering	2011
Angioedema associated with dihydropyridine calcium-channel blockers in a child with Burkitt lymphoma. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2011, Mar-01, Volume: 68, Issue:5 Topics: Amlodipine; Angioedema; Burkitt Lymphoma; Calcium Channel Blockers; Child; Humans; Hypertension; Macroglossia; Male; Nicardipine; Severity of Illness Index; Tumor Lysis Syndrome	2011
Distinct properties of amlodipine and nicardipine block of the voltage-dependent Ca2+ channels Cav1.2 and Cav2.1 and the mutant channels Cav1.2/dihydropyridine insensitive and Cav2.1/dihydropyridine sensitive. European journal of pharmacology, 2011, Nov-16, Volume: 670, Issue:1 Topics: Amino Acid Sequence; Amlodipine; Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Dihydropyridines; HEK293 Cells; Humans; Molecular Sequence Data; Mutation; Nicardipine; Protein Conformation	2011
Pharmacokinetic drug-drug interaction of calcium channel blockers with cyclosporine in hematopoietic stem cell transplant children. The Annals of pharmacotherapy, 2014, Volume: 48, Issue:12 Topics: Adolescent; Amlodipine; Calcium Channel Blockers; Child; Child, Preschool; Cyclosporine; Dihydropyridines; Drug Interactions; Female; Hematopoietic Stem Cell Transplantation; Humans; Hypertension; Immunosuppressive Agents; Infant; Male; Nicardipine; Retrospective Studies	2014
Retinal region-dependent susceptibility of capillaries to high-concentration oxygen exposure and vascular endothelial growth factor receptor inhibition in neonatal mice. Journal of pharmacological sciences, 2015, Volume: 129, Issue:2 Topics: Amlodipine; Animals; Animals, Newborn; Axitinib; Calcium Channel Blockers; Capillaries; Female; Hyperoxia; Imidazoles; Indazoles; Male; Mice, Inbred ICR; Nicardipine; Oxygen; Protein Kinase Inhibitors; Receptors, Vascular Endothelial Growth Factor; Retinal Artery; Time Factors; Vasoconstriction	2015
Without Warning: Scleroderma Renal Crisis. The American journal of medicine, 2019, Volume: 132, Issue:2 Topics: Acute Kidney Injury; Amlodipine; Antihypertensive Agents; Humans; Hypertension; Labetalol; Lisinopril; Male; Nicardipine; Scleroderma, Limited	2019
Nephrotic range proteinuria and metabolic alkalosis in Takayasu arteritis. BMJ case reports, 2019, Apr-15, Volume: 12, Issue:4 Topics: Adolescent; Alkalosis; Amlodipine; Antihypertensive Agents; Female; Glomerulosclerosis, Focal Segmental; Headache; Humans; Hypertension, Renovascular; Nicardipine; Proteinuria; Takayasu Arteritis	2019