amlodipine and aspirin

amlodipine has been researched along with aspirin in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.63)18.2507
2000's14 (36.84)29.6817
2010's22 (57.89)24.3611
2020's1 (2.63)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Folts, JD1
Ahn, YK; Bae, Y; Cho, JG; Cho, JH; Jeong, MH; Kang, JC; Kang, KT; Kim, KH; Kim, NH; Kim, SH; Lee, SH; Park, JC; Rhew, JY1
Parke, AL; White, WB1
De la Figuera von Wichmann, M; Llisterri Caro, JL1
Carroll, TJ; Famuboni, A; Patel, MD; Starke, ID; Umasankar, U1
Yee, J1
Sundermeyer, M; Veeraputhiran, M1
Barnett, PG; Boden, WE; Bowen, J; Deaton, C; Dunbar, SB; Goeree, R; Hartigan, PM; Jurkovitz, C; Kaufman, S; Kolm, P; Lewis, C; Mancini, GB; Maron, DJ; O'Rourke, RA; Spertus, JA; Teo, KK; Veledar, E; Weintraub, WS; Zhang, W; Zhang, Z1
Accardo, S; Americo, L; Castello, A; Cicero, S; Sarullo, FM; Schicchi, R; Schirò, M1
Huang, J; Huang, Y; Wang, T1
Spence, JD1
Boytsov, S; Deev, A; Dupik, N; Kolos, I; Loukianov, M1
Dominguez, L; Solis, A; Vigil-De Gracia, P1
de Ceuninck, M; Trenson, S1
Kartashova, EA; Romantsov, MG; Sarvilina, IV1
Ahmed, FR; Khan, MA; Manzoor, S; Nasiri, MI; Salam, FA; Shoaib, MH; Sultan, F; Yousuf, RI1
Jiang, N; Liu, L; Liu, Q; Yang, WW; Zeng, Y1
D'Angelo, A; Derosa, G; Maffioli, P; Mugellini, A; Pesce, RM1
Abdollahpour, N; Chamani, J; Saberi, MR; Soheili, V1
Luteijn, JM; Morris, JK; Oppenheimer, P; Taylor, D; Wald, NJ1
Abu-Ghazaleh, D; Al-Ramahi, R; Bsharat, A; Raddad, AR; Rashed, AO; Shehab, O; Yasin, E1
Kotegawa, T; Koya, Y; Machi, Y; Namiki, N; Shobu, Y; Uchida, S1
Borek-Dohalska, L; Fojtikova, V; Martinkova, M; Mináriková, M; Sedláček, J; Šikut, M; Stiborová, M; Vyskočilová, E1
Bridgeman, MB; Dalal, KS1
Singh, A; Tafoya, C1
Fu, J; Li, B; Wang, T; Zhao, N1

Reviews

3 review(s) available for amlodipine and aspirin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Overview of cardiovascular risk factors].
    Medicina clinica, 2006, Nov-25, Volume: 127, Issue:20

    Topics: Age Factors; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aspirin; Calcium Channel Blockers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Europe; Female; Humans; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Male; Meta-Analysis as Topic; Perindopril; Platelet Aggregation Inhibitors; Primary Prevention; Prospective Studies; Randomized Controlled Trials as Topic; Risk Factors; Sex Factors; Smoking Prevention; Spain; Vasodilator Agents

2006
Cardiac Memory: A Case Report and Review of the Literature.
    The Journal of emergency medicine, 2019, Volume: 57, Issue:1

    Topics: Aged; Amlodipine; Arrhythmias, Cardiac; Aspirin; Bundle-Branch Block; Chest Pain; Electrocardiography; Emergency Service, Hospital; Enalapril; Headache; Heart Ventricles; Humans; Isosorbide Dinitrate; Male; Nausea; Nitroglycerin; Platelet Aggregation Inhibitors; Vasodilator Agents; Vomiting

2019

Trials

6 trial(s) available for amlodipine and aspirin

ArticleYear
Effect of PCI on quality of life in patients with stable coronary disease.
    The New England journal of medicine, 2008, Aug-14, Volume: 359, Issue:7

    Topics: Adrenergic beta-Antagonists; Amlodipine; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Calcium Channel Blockers; Clopidogrel; Combined Modality Therapy; Coronary Disease; Cross-Over Studies; Drug Therapy, Combination; Female; Health Status; Humans; Isosorbide Dinitrate; Male; Metoprolol; Middle Aged; Patient Satisfaction; Platelet Aggregation Inhibitors; Quality of Life; Stents; Surveys and Questionnaires; Ticlopidine; Vasodilator Agents

2008
Optimal medical treatment versus carotid endarterectomy: the rationale and design of the Aggressive Medical Treatment Evaluation for Asymptomatic Carotid Artery Stenosis (AMTEC) study.
    International journal of stroke : official journal of the International Stroke Society, 2015, Volume: 10, Issue:2

    Topics: Amlodipine; Antihypertensive Agents; Aspirin; Carotid Stenosis; Combined Modality Therapy; Endarterectomy, Carotid; Fibrinolytic Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Losartan; Myocardial Infarction; Prospective Studies; Research Design; Russia; Stroke

2015
Management of chronic hypertension during pregnancy with furosemide, amlodipine or aspirin: a pilot clinical trial.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2014, Volume: 27, Issue:13

    Topics: Adult; Amlodipine; Antihypertensive Agents; Aspirin; Diuretics; Female; Furosemide; Humans; Hypertension, Pregnancy-Induced; Pilot Projects; Pregnancy; Treatment Outcome

2014
[The influence of citoflavin on molecular mechanisms of hypertensive encephalopathy development in patients with systolic arterial hypertension].
    Eksperimental'naia i klinicheskaia farmakologiia, 2014, Volume: 77, Issue:6

    Topics: Aged; Aged, 80 and over; Amlodipine; Aspirin; Atorvastatin; Blood Pressure; Blood Proteins; Drug Combinations; Drug Therapy, Combination; Echocardiography; Female; Flavin Mononucleotide; Hemodynamics; Heptanoic Acids; Humans; Hypertension; Hypertensive Encephalopathy; Inosine Diphosphate; Male; Neuroprotective Agents; Niacinamide; Pyrroles; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Succinates; Systole; Tetrazoles; Valine; Valsartan

2014
A study about the relevance of adding acetylsalicylic acid in primary prevention in subjects with type 2 diabetes mellitus: effects on some new emerging biomarkers of cardiovascular risk.
    Cardiovascular diabetology, 2015, Jul-30, Volume: 14

    Topics: Aged; Amlodipine; Antihypertensive Agents; Aspirin; Biomarkers; Calcium Channel Blockers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Inflammation Mediators; Italy; Male; Middle Aged; Platelet Aggregation Inhibitors; Predictive Value of Tests; Primary Prevention; Risk Factors; Time Factors; Treatment Outcome

2015
The Efficacy of Rosuvastatin, Amlodipine, and Aspirin in the Treatment of Hypertension with Coronary Heart Disease and Its Effect on Platelet Aggregation.
    Disease markers, 2022, Volume: 2022

    Topics: Amlodipine; Antihypertensive Agents; Aspirin; Coronary Disease; Humans; Hypertension; Lipids; Platelet Aggregation; Rosuvastatin Calcium; Stroke Volume; Treatment Outcome; Ventricular Function, Left

2022

Other Studies

29 other study(ies) available for amlodipine and aspirin

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Inhibition of platelet activity in vivo by amlodipine alone and combined with aspirin.
    International journal of cardiology, 1997, Dec-31, Volume: 62 Suppl 2

    Topics: Amlodipine; Animals; Aspirin; Blood Flow Velocity; Blood Platelets; Calcium Channel Blockers; Coronary Thrombosis; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Epinephrine; Infusions, Intravenous; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasoconstrictor Agents

1997
Successful management of intractable coronary spasm with a coronary stent.
    Japanese circulation journal, 2000, Volume: 64, Issue:11

    Topics: Adult; Amlodipine; Aspirin; Calcium Channel Blockers; Cardiovascular Agents; Coronary Angiography; Coronary Artery Disease; Coronary Vasospasm; Diltiazem; Doxazosin; Drug Resistance; Drug Therapy, Combination; Ergonovine; Humans; Isosorbide Dinitrate; Male; Myocardial Infarction; Nicorandil; Nitrates; Pyridines; Stents; Ticlopidine; Ventricular Fibrillation

2000
Acute pain in the tip of the index finger.
    The American journal of medicine, 2005, Volume: 118, Issue:11

    Topics: Acute Disease; Amlodipine; Arterial Occlusive Diseases; Aspirin; Cyanosis; Diagnostic Errors; Female; Fingers; Hand Injuries; Hemorrhage; Humans; Hypertension; Ischemia; Middle Aged; Nail Diseases; Pain; Pressure; Radial Artery; Raynaud Disease; Skiing; Thumb; Ultrasonography, Doppler

2005
Vertebral artery dissection: not a rare cause of stroke in the young.
    Age and ageing, 2008, Volume: 37, Issue:3

    Topics: Adult; Amlodipine; Anticoagulants; Antihypertensive Agents; Aspirin; Craniocerebral Trauma; Female; Hemianopsia; Humans; Hypertension; Magnetic Resonance Angiography; Stroke; Tomography, X-Ray Computed; Vertebral Artery Dissection; Warfarin

2008
Chronic kidney disease--a disease domain complex.
    Geriatrics, 2008, Volume: 63, Issue:3

    Topics: Aged; Alendronate; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Bone Density Conservation Agents; Calcium; Diabetes Mellitus, Type 2; Disease Progression; Drug Therapy; Female; Glomerular Filtration Rate; Humans; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Long-Acting; Kidney Failure, Chronic; Metoprolol; Nitroglycerin; Sulfonamides; Thiophenes

2008
Rhabdomyolysis resulting from pharmacologic interaction between erlotinib and simvastatin.
    Clinical lung cancer, 2008, Volume: 9, Issue:4

    Topics: Aged; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atenolol; Azetidines; Carcinoma, Non-Small-Cell Lung; Coronary Artery Disease; Drug Interactions; Erlotinib Hydrochloride; Ezetimibe; Female; Humans; Hyperlipidemias; Hypertension; Lung Neoplasms; Neoplasm Recurrence, Local; Protein Kinase Inhibitors; Quinazolines; Rhabdomyolysis; Simvastatin; Tomography, X-Ray Computed

2008
Tako-tsubo cardiomyopathy observed in a patient with sepsis and transient hyperthyroidism.
    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, 2009, Volume: 72, Issue:1

    Topics: Amlodipine; Anti-Bacterial Agents; Antihypertensive Agents; Antithyroid Agents; Aspirin; Echocardiography; Electrocardiography; Female; Glucocorticoids; Humans; Hyperthyroidism; Methimazole; Middle Aged; Ofloxacin; Platelet Aggregation Inhibitors; Prednisone; Propranolol; Ramipril; Sepsis; Takotsubo Cardiomyopathy

2009
Exfoliative esophagitis in a patient with metastatic renal cell carcinoma during sunitinib treatment.
    Medical oncology (Northwood, London, England), 2013, Volume: 30, Issue:1

    Topics: Amlodipine; Antihypertensive Agents; Antineoplastic Agents; Aspirin; Carcinoma, Renal Cell; Cyclooxygenase 2 Inhibitors; Esophagitis; Humans; Hypertension; Indoles; Kidney Neoplasms; Lung Neoplasms; Male; Middle Aged; Nephrectomy; Pyrroles; Sunitinib; Tetrazoles; Valine; Valsartan

2013
Asymptomatic carotid stenosis.
    Circulation, 2013, Feb-12, Volume: 127, Issue:6

    Topics: Aged; Amlodipine; Anticholesteremic Agents; Aspirin; Asymptomatic Diseases; Atorvastatin; Azetidines; Carotid Stenosis; Diet, Mediterranean; Drug Therapy, Combination; Exercise Therapy; Ezetimibe; Female; Heptanoic Acids; Humans; Perindopril; Pyrroles; Risk; Stroke; Treatment Outcome; Ultrasonography; Vasodilator Agents

2013
A calcified left ventricular mass.
    Acta cardiologica, 2014, Volume: 69, Issue:3

    Topics: Aged, 80 and over; Aging; Amlodipine; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Calcinosis; Diagnosis, Differential; Female; Heart Neoplasms; Heart Valve Diseases; Heptanoic Acids; Humans; Hypertension; Mitral Valve; Monitoring, Physiologic; Platelet Aggregation Inhibitors; Pyrroles; Quinapril; Radiography; Tetrahydroisoquinolines; Treatment Outcome

2014
Simultaneous quantitation of aspirin, amlodipine and simvastatin in a fixed dose combination of encapsulated tablet formulation by HPLC-UV method.
    Pakistan journal of pharmaceutical sciences, 2014, Volume: 27, Issue:5 Spec no

    Topics: Amlodipine; Aspirin; Cardiovascular Agents; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drug Combinations; Limit of Detection; Reproducibility of Results; Simvastatin; Spectrophotometry, Ultraviolet; Tablets; Technology, Pharmaceutical

2014
The effect of calcium channel blockers on prevention of preeclampsia in pregnant women with chronic hypertension.
    Clinical and experimental obstetrics & gynecology, 2015, Volume: 42, Issue:1

    Topics: Adult; Amlodipine; Aspirin; Birth Weight; Blood Pressure; Calcium Channel Blockers; China; Female; Humans; Hypertension; Incidence; Infant, Newborn; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Prognosis; Retrospective Studies

2015
Investigation of the Interaction Between Human Serum Albumin and Two Drugs as Binary and Ternary Systems.
    European journal of drug metabolism and pharmacokinetics, 2016, Volume: 41, Issue:6

    Topics: Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Binding Sites; Chemical Phenomena; Drug Interactions; Drug Stability; Humans; Kinetics; Models, Molecular; Molecular Structure; Particle Size; Protein Conformation; Protein Stability; Protein Unfolding; Quantitative Structure-Activity Relationship; Serum Albumin, Human; Solubility; Surface Properties

2016
Cost-benefit analysis of the polypill in the primary prevention of myocardial infarction and stroke.
    European journal of epidemiology, 2016, Volume: 31, Issue:4

    Topics: Aged; Aged, 80 and over; Amlodipine; Aspirin; Cardiovascular Agents; Case-Control Studies; Cohort Studies; Cost-Benefit Analysis; Humans; Hydrochlorothiazide; Losartan; Markov Chains; Middle Aged; Myocardial Infarction; Polypharmacy; Primary Prevention; Quality-Adjusted Life Years; Simvastatin; Stroke; United Kingdom

2016
Evaluation of potential drug- drug interactions among Palestinian hemodialysis patients.
    BMC nephrology, 2016, 07-26, Volume: 17

    Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Arabs; Aspirin; Calcium Carbonate; Comorbidity; Diabetes Mellitus; Drug Interactions; Drug Prescriptions; Female; Gout; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Middle East; Polypharmacy; Renal Dialysis; Retrospective Studies; Risk Factors

2016
Prediction of drug interaction between oral adsorbent AST-120 and concomitant drugs based on the in vitro dissolution and in vivo absorption behavior of the drugs.
    European journal of clinical pharmacology, 2016, Volume: 72, Issue:11

    Topics: Administration, Oral; Adsorption; Aluminum Hydroxide; Amlodipine; Aspirin; Carbon; Drug Interactions; Glycine; Humans; Intestinal Absorption; Losartan; Magnesium; Metoprolol; Models, Biological; Nifedipine; Oxides; Renal Insufficiency, Chronic; Solubility; Triazolam

2016
The capacity and effectiveness of diosmectite and charcoal in trapping the compounds causing the most frequent intoxications in acute medicine: A comparative study.
    Environmental toxicology and pharmacology, 2017, Volume: 52

    Topics: Adsorption; Alpha-Amanitin; Amlodipine; Antidotes; Aspirin; Carbamazepine; Charcoal; Digoxin; Ibuprofen; Imipramine; Oxazepam; Phenobarbital; Poisoning; Promethazine; Silicates; Theophylline

2017
Combination cardiovascular drugs.
    Nursing, 2017, Volume: 47, Issue:8

    Topics: Aminobutyrates; Amlodipine; Aspirin; Biphenyl Compounds; Cardiovascular Agents; Cardiovascular Diseases; Drug Combinations; Humans; Nebivolol; Omeprazole; Perindopril; Tetrazoles; Valsartan

2017