amlexanox and alpha-aminopyridine

amlexanox has been researched along with alpha-aminopyridine in 109 studies

Research

Studies (109)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (9.17)	18.7374
1990's	24 (22.02)	18.2507
2000's	21 (19.27)	29.6817
2010's	34 (31.19)	24.3611
2020's	20 (18.35)	2.80

Authors

Authors	Studies
Go, K; Namimatsu, A; Okuda, M; Tanimoto, H	1
Daikoku, M; Iwama, T; Koda, A; Nagai, H; Suda, H; Yanagihara, Y	1
Aris, K; Hayakawa, R; Matsunaga, K; Ogino, Y	1
Inagaki, M; Kobayashi, S; Michimata, H; Minato, K; Nakazawa, T; Sunaga, Y; Tani, G	1
Azuma, H; Ito, Y; Kato, H; Koda, A; Makino, E; Nagai, H; Ohashi, T; Takahashi, H	2
Horiba, F; Iimi, K; Kondo, Y; Masuda, S; Torii, S; Tsuruta, M; Urisu, A; Yazaki, T	1
Izushi, K; Kamei, C; Tasaka, K	1
Kabasawa, Y; Kanzaki, T	1
Kawashima, M; Yamashita, H	1
Fukuda, M; Rankov, G; Sasaki, K	1
Ahida, Y; Nonoyama, T; Sakakura, Y; Ukai, K	1
Ashida, Y; Kuriki, H; Maki, Y; Makino, H; Saijo, T	3
Kuriki, H; Kushumi, T; Matsumoto, T; Mizukoshi, F; Shoji, H; Takenaka, H	1
Mita, H; Sakuma, Y	1
Hitomi, S; Kawai, M; Kohno, S; Mizuta, J; Ogino, K; Ohata, K; Shimizu, T; Shindo, T; Wada, H; Yamamura, H	1
Kondo, M; Naito, Y; Oyamada, H; Sugino, S; Takahashi, S; Takemura, T; Tanigawa, T; Ueda, S; Yoshikawa, T	1
Ashida, Y; Kuriki, H; Maki, Y; Makino, H; Saijo, T; Tamura, S; Terao, S	1
Ikejiri, Y; Ogawa, T; Ohira, M; Sakaue, T	1
Ishiguro, T; Kuriki, H; Nohara, A; Ukawa, K	1
Aihara, M; Hariya, T; Ikezawa, Z; Kitamura, K; Nakajima, H; Osawa, J	1
Chida, K; Hayakawa, H; Imokawa, S; Nakazawa, K; Satou, A; Taniguchi, M; Toyoshima, M	1
Greer, RO; Juarez, T; Khandwala, A; Lindenmuth, JE	1
Maeda, Y; Nagai, H; Tanaka, H; Yamaguchi, S	1
Alfano, MC; Khandwala, A; Van Inwegen, RG	1
Alfano, MC; Charney, MR; Khandwala, A; Van Inwegen, RG	1
Kobayashi, R; Maeta, H; Nakagiri, S; Naya, T; Oyama, Y; Shishibori, T; Yamashita, K	1
Hayakawa, R; Osada, T; Sugiura, M	1
Binnie, WH; Curro, FA; Khandwala, A; Van Inwegan, RG	1
Burgess, WH; Hampton, B; Jackson, A; Lathrop, JT; LaVallee, TM; Maciag, T; Mouta Carreira, C; Tarantini, F	1
Furuichi, H; Hata, Y; Kobayashi, R; Maeta, H; Matsushita, O; Okabe, A; Oyama, Y; Shishibori, T; Yamashita, K	1
Kobayashi, R; Matsushita, O; Okabe, A; Oyama, Y; Shishibori, T; Yamashita, K	1
Gomi, Y; Isaka, M; Ogawa, T; Ushijima, HT; Watanabe, N; Yorozuya, T	1
Landriscina, M; Maciag, T; Mouta Carreira, C; Prudovsky, I; Soldi, R; Tarantini, F	1
Bellum, S; Garfinkel, S; Landriscina, M; Maciag, T; Micucci, I; Prudovsky, I; Tarantini, F	1
Gomi, Y; Mizutani, K; Ogawa, T; Tominaga, Y; Tsunobuchi-Ushijima, H; Watanabe, N	1
Barrons, RW	1
Bellum, S; Landriscina, M; Maciag, T; Mouta Carreira, C; Prudovsky, I	1
Eisen, D; Lynch, DP	1
Kobayashi, R; Kubota, Y; Okada, M; Tokumitsu, H	1
Hatakeyama, T; Itoh, H; Kobayashi, R; Okada, M; Tokumitsu, H	1
Biagioni, P; Hyland, P; Lamey, PJ; McGuinness, N; Murray, B	1
Graziani, I; Kumar, TK; Prudovsky, I; Rajalingam, D; Soldi, R; Yu, C	1
Biagioni, PA; Lamey, PJ; Murray, B	1
Matsunaga, H; Ueda, H	2
Hasegawa, K; Kaneko, S; Kishimoto, K; Ohmori, K; Tamura, T	1
Inaba, T; Shishikura, T; Shito, K; Uchida, M	1
Cai, Y; Chen, F; Chen, Q; Lin, M; Liu, J; Shi, J; Wang, Y; Wang, Z; Zeng, X; Zhang, Y; Zhou, H	1
Rodríguez, M; Rubio, JA; Sanchez, R	1
Burgess, JA; Haley, J; Martin, M; Sherman, J; van der Ven, PF	1
Höger, P	1
Chen, Q; Chen, R; Dong, Y; Gao, F; Jiang, L; Lin, M; Liu, J; Meng, W; Wang, Z; Xu, T; Zeng, X; Zhong, X; Zhou, H	1
Mohan, SK; Rani, SG; Yu, C	1
Bailey, J; McCarthy, C; Smith, RF	1
Chen, Q; Dan, H; Fu, J; Jiang, L; Li, Y; Liu, C; Liu, N; Wang, F; Xu, Y; Zeng, X; Zhou, Y; Zhu, X	1
Beghyn, T; Berte, G; Debreuck, N; Déprez, B; Gonzalez-Hilarion, S; Gruenert, DC; Jia, J; Lejeune, F; Mamchaoui, K; Mouly, V	1
Chang, L; Chiang, SH; Decker, SJ; Downes, M; Evans, RM; Hochberg, I; Larsen, MJ; Li, P; Liddle, C; Mowers, J; Oh, D; Olefsky, JM; Reilly, SM; Rubin, JR; Saltiel, AR; Uhm, M; White, NM; Yu, RT	1
Calay, ES; Hotamisligil, GS	1
Chang, L; Chiang, SH; Leto, D; Mowers, J; Reilly, SM; Saltiel, AR; Simon, J; Uhm, M	1
Becker, P; Greeff, O; Xaba, SN	1
Cannavo, A; Homan, KT; Koch, WJ; Tesmer, JJ; Wu, E	1
Ahmadian, M; Chang, L; Downes, M; Evans, RM; Korytnaya, E; Krause, DM; Liddle, C; Lumeng, CN; Neidert, A; Oral, EA; Peng, X; Poirier, B; Reilly, SM; Saltiel, AR; Uhm, M; Yu, RT; Zamarron, BF	1
Koide, N; Mori, D; Nagata, H; Nonami, T; Sano, T; Tsolmongyn, B; Yokochi, T	1
Belal, F; Halawa, MI; Tolba, MM; Walash, MI	1
Chen, W; Fang, Z; Guan, H; Li, F; Li, J; Zhang, Y	1
Geisslinger, G; King-Himmelreich, TS; Laarmann, K; Meissner, M; Möser, CV; Niederberger, E; Olbrich, K; Wolters, MC	1
Anjana, R; Jaishankar, HP; Jijin, MJ; Kavitha, AP; Krupashankar, R; Pai, J; Rakaraddi, M; Shobha, R	1
Gadicherla, S; Pentapati, KC; Smriti, K	1
Cho, CC; Chou, RH; Yu, C	1
Atanasova, VS; Bruckner-Tuderman, L; Chen, M; Gruber, C; Has, C; Jiang, Q; McGrath, JA; Piñón Hofbauer, J; Prisco, M; South, AP; Uitto, J	1
Ahmadian, M; Ajluni, N; Butz, L; Chenevert, TL; Downes, M; Evans, RM; Gomez, AV; Hench, R; Horowitz, JF; Jain, M; Korytnaya, E; Lehmann, K; Liddle, C; Meral, R; Neidert, AH; Oral, EA; Poirier, B; Reilly, SM; Rus, D; Saltiel, AR; Yu, R; Zhao, P	1
Blednov, YA; Bridges, CR; Harris, RA; McCarthy, GM; Warden, AS	1
Dong, S; Guo, G; Huang, Q; Li, R; Liu, Y; Lu, J; Nan, Y; Yu, K; Zhang, Z; Zhong, Y; Zhu, L	1
Banning, A; Schiff, M; Tikkanen, R	1
Halder, SK; Ueda, H	1
Chen, M; Cheng, Y; Guan, J; Jiao, S; Li, C; Wang, W; Wang, Y; Zhou, Z	1
Jiang, F; Li, X; Sun, LC; Wang, Y; Wu, GM; Zeng, W; Zheng, Y; Zhou, LF	1
Arner, EN; Brekken, RA; Cruz, VH; Scherer, PE; Wynne, KW	1
Beyett, TS; Chang, L; Gan, X; Gomez, AV; Reilly, SM; Saltiel, AR; Showalter, HD; Tesmer, JJG	1
Fleck, SC; Geisslinger, G; Möller, M; Möser, CV; Niederberger, E; Thomas, D	1
Allen, RJ; Bishop, RT; de Ridder, D; Idris, AI; Lefley, DV; Marino, S; Ottewell, PD; Sims, AH; Wang, N	1
Chen, LP; Deng, XH; Guo, L; Han, X; He, XX; Hou, HQ; Jia, Z; Liu, HJ; Ma, TZ; Quan, MY; Song, XJ	1
Beyett, TS; Gan, X; Larsen, SD; Saltiel, AR; Showalter, HD; Sun, D; Tesmer, JJG; Wen, B; Wilson, MW	1
Coban, C; Ishii, KJ; Ito, S; Kobari, S; Kobiyama, K; Kuroda, E; Kusakabe, T; Momota, M; Ozasa, K; Temizoz, B	1
He, Q; Tang, R; Wang, W; Wu, Q; Xia, X; Yao, K; Zeng, J; Zou, X	2
Akasaki, Y; Bekki, H; Goto, N; Hayashida, M; Kurakazu, I; Kuwahara, M; Lotz, MK; Nakashima, Y; Sueishi, T; Toya, M; Tsushima, H; Uchida, T	1
Kim, B; Kim, JW; Lim, CW; Qi, J; Zhou, Z	2
Kim, B; Kim, JW; Lim, CW; Qi, J; Zhao, J; Zhou, Z	1
Bentham, RB; Bianchi, K; Carter, E; Dalli, J; Godinho, SA; Grose, R; Hodivala-Dilke, K; Holdsworth, J; Ironside, A; Jones, L; Jones, W; Mataloni, I; Moreno Béjar, R; Szabadkai, G; Uhlik, L; Wilcz-Villega, E; Xu, R	1
Cai, R; Gao, Y; Han, Y; Hou, R; Li, X; Liu, H; Qi, R; Qi, Y; Zhang, X	1
Meissner, M; Möller, M; Möser, CV; Niederberger, E; Schiffmann, S; Schmetzer, J; Wasel, J; Weigert, A; Weiß, U	1
Li, Y; Ma, Z; Wang, N; Wang, X; Wang, Y; Yuan, Y; Zhang, C; Zhao, M	1
Afriyie-Asante, A; Deb, B; Fairclough, LC; Joseph, B; Lanyon, P; Sutherland, L; Thomas, RE; Tighe, PJ; Todd, I; Watt, BD	1
Dosanjh, A; Won, CY	1
Ishikawa, S; Nakajima, M; Okuyama, S; Sawamoto, A	1
Abu-Odeh, M; Ameka, M; Dadpey, B; DeLuca, JH; Ebadat, N; Gomez, AV; Naber, MC; Peng, X; Poirier, B; Potthoff, MJ; Reilly, SM; Saltiel, AR; Walk, E	1
Kihara, A; Takeda, K; Yamada, K; Yano, K	1
Baarsma, HA; Campillos, M; Costa, R; De Santis, MM; Doryab, A; Hadian, K; Königshoff, M; Lehmann, M; Liu, X; Rothenaigner, I; Schmid, O; Schorpp, K; Wagner, DE; Yildirim, AÖ	1
Dorocka-Bobkowska, B; Ślebioda, Z; Łukaszewska-Kuska, M	1
Eintracht, J; Forsythe, E; May-Simera, H; Moosajee, M	1
Bailly, C	1
Glass, CK; Li, D; Liao, Z; Saltiel, AR; Shen, Z; Sun, X; Witztum, JL; Yu, H; Zhao, P	1
Guo, Y; Guo, Z; Han, Q; Hu, J; Hu, X; Jin, S; Song, D; Wang, X; Yang, T; Zhao, J	1
Cheng, YO; Gopinath, D; Shetty, NY; Syeed, MS; Veettil, SK	1

Reviews

10 review(s) available for amlexanox and alpha-aminopyridine

Article	Year
Fixed drug eruption due to amlexanox. Contact dermatitis, 1998, Volume: 38, Issue:2 Topics: Adult; Aged; Aminopyridines; Anti-Allergic Agents; Drug Eruptions; Erythema; Female; Humans; Male; Middle Aged; Patch Tests; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal	1998
Treatment strategies for recurrent oral aphthous ulcers. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2001, Jan-01, Volume: 58, Issue:1 Topics: Adjuvants, Immunologic; Administration, Topical; Adrenal Cortex Hormones; Aminopyridines; Anti-Inflammatory Agents; Controlled Clinical Trials as Topic; Dermatologic Agents; Food Hypersensitivity; HIV Infections; Levamisole; Mouthwashes; Stomatitis, Aphthous; Thalidomide; Wounds and Injuries	2001
Selecting topical and systemic agents for recurrent aphthous stomatitis. Cutis, 2001, Volume: 68, Issue:3 Topics: Administration, Topical; Aminopyridines; Anti-Inflammatory Agents; Humans; Prednisone; Recurrence; Stomatitis, Aphthous	2001
Review of over-the-counter treatments for aphthous ulceration and results from use of a dissolving oral patch containing glycyrrhiza complex herbal extract. The journal of contemporary dental practice, 2008, Mar-01, Volume: 9, Issue:3 Topics: Aminopyridines; Anesthetics, Local; Cyanoacrylates; Glycyrrhiza; Hematinics; Humans; Mouthwashes; Nonprescription Drugs; Oxidants; Phytotherapy; Plant Extracts; Plant Roots; Randomized Controlled Trials as Topic; Stomatitis, Aphthous; Tissue Adhesives	2008
Clinical inquiry. What is the most effective way to treat recurrent canker sores? The Journal of family practice, 2011, Volume: 60, Issue:10 Topics: Administration, Topical; Aminopyridines; Anti-Allergic Agents; Anti-Infective Agents, Local; Anti-Inflammatory Agents; Beclomethasone; Cautery; Clobetasol; Eupatorium; Humans; Mouthwashes; Pain; Phytotherapy; Plant Preparations; Secondary Prevention; Stomatitis, Aphthous; Vitamin B 12	2011
Amlexanox Enhances Premature Termination Codon Read-Through in COL7A1 and Expression of Full Length Type VII Collagen: Potential Therapy for Recessive Dystrophic Epidermolysis Bullosa. The Journal of investigative dermatology, 2017, Volume: 137, Issue:9 Topics: Aminopyridines; Codon, Nonsense; Collagen Type VII; Epidermolysis Bullosa Dystrophica; Female; Gene Expression Regulation; Genes, Recessive; Genetic Predisposition to Disease; Humans; Male; Molecular Targeted Therapy; Mutation; Pedigree; Prognosis	2017
Amlexanox: A Novel Therapeutic for Atopic, Metabolic, and Inflammatory Disease. The Yale journal of biology and medicine, 2020, Volume: 93, Issue:5 Topics: Aminopyridines; Animals; Anti-Allergic Agents; Asthma; Humans; Hypersensitivity, Immediate; Inflammation; Japan; Signal Transduction	2020
The effectiveness of topical forms of dexamethasone in the treatment of oral lichen planus- A systematic review. Oral diseases, 2022, Volume: 28, Issue:8 Topics: Administration, Topical; Aminopyridines; Amitriptyline; Clobetasol; Dexamethasone; Humans; Ketoconazole; Lichen Planus, Oral; Methylene Blue; Mouthwashes; Thalidomide	2022
The potential value of amlexanox in the treatment of cancer: Molecular targets and therapeutic perspectives. Biochemical pharmacology, 2022, Volume: 197 Topics: Aminopyridines; Animals; Antineoplastic Agents; Drug Delivery Systems; Humans; Neoplasms; Treatment Outcome	2022
COMPARATIVE EFFICACY OF THERAPEUTIC INTERVENTIONS FOR THE MANAGEMENT OF RECURRENT APHTHOUS ULCERS: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS. The journal of evidence-based dental practice, 2023, Volume: 23, Issue:4 Topics: Aminopyridines; Humans; Network Meta-Analysis; Pain; Stomatitis, Aphthous	2023

Trials

15 trial(s) available for amlexanox and alpha-aminopyridine

Article	Year
[Inhibitory effect of AA-673 eye drops on ocular provocation for Japanese cedar pollinosis]. Arerugi = [Allergy], 1989, Volume: 38, Issue:2 Topics: Adolescent; Adult; Aged; Aminopyridines; Depression, Chemical; Female; Histamine Release; Humans; Male; Middle Aged; Ophthalmic Solutions; Pollen; Rhinitis, Allergic, Seasonal	1989
[Amlexanox has an acute bronchodilator effect in patients with aspirin-induced asthma (AIA)]. Nihon Kyobu Shikkan Gakkai zasshi, 1993, Volume: 31, Issue:8 Topics: Adult; Aged; Aminopyridines; Aspirin; Asthma; Bronchi; Bronchoconstriction; Bronchodilator Agents; Double-Blind Method; Female; Humans; Male; Middle Aged	1993
A double-blind study of topically applied 5% amlexanox in the treatment of aphthous ulcers. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1993, Volume: 51, Issue:3 Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Aminopyridines; Anti-Inflammatory Agents; Double-Blind Method; Drug Tolerance; Erythema; Humans; Middle Aged; Ointments; Pain; Patient Compliance; Placebos; Recurrence; Stomatitis, Aphthous	1993
5% amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers: I. Clinical demonstration of acceleration of healing and resolution of pain. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1997, Volume: 83, Issue:2 Topics: Administration, Topical; Adult; Aminopyridines; Analysis of Variance; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Female; Humans; Logistic Models; Male; Pain Measurement; Pharmaceutical Vehicles; Statistics, Nonparametric; Stomatitis, Aphthous; Treatment Outcome	1997
5% amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers: II. Pharmacokinetics and demonstration of clinical safety. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1997, Volume: 83, Issue:2 Topics: Administration, Topical; Adult; Aminopyridines; Anti-Inflammatory Agents; Area Under Curve; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Intestinal Absorption; Logistic Models; Male; Metabolic Clearance Rate; Patch Tests; Safety; Skin; Stomatitis, Aphthous	1997
Amlexanox oral paste: a novel treatment that accelerates the healing of aphthous ulcers. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 1997, Volume: 18, Issue:11 Topics: Administration, Topical; Adult; Aminopyridines; Anti-Inflammatory Agents; Chi-Square Distribution; Double-Blind Method; Female; Humans; Logistic Models; Male; Pain Measurement; Stomatitis, Aphthous	1997
A comparative study of the efficacy of Aphtheal in the management of recurrent minor aphthous ulceration. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2005, Volume: 34, Issue:7 Topics: Adult; Aminopyridines; Anti-Allergic Agents; Body Temperature; Erythema; Female; Humans; Male; Secondary Prevention; Stomatitis, Aphthous; Treatment Outcome	2005
The efficacy of amlexanox OraDisc on the prevention of recurrent minor aphthous ulceration. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2006, Volume: 35, Issue:2 Topics: Administration, Topical; Adult; Aminopyridines; Anti-Allergic Agents; Body Temperature; Double-Blind Method; Erythema; Female; Humans; Male; Mouth Mucosa; Pain; Placebos; Recurrence; Safety; Stomatitis, Aphthous; Thermography; Time Factors; Treatment Outcome; Wound Healing	2006
An evaluation on the efficacy and safety of amlexanox oral adhesive tablets in the treatment of recurrent minor aphthous ulceration in a Chinese cohort: a randomized, double-blind, vehicle-controlled, unparallel multicenter clinical trial. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2006, Volume: 102, Issue:4 Topics: Adhesives; Adolescent; Adult; Aged; Aminopyridines; Anti-Allergic Agents; Cohort Studies; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Erythema; Female; Humans; Male; Middle Aged; Pain; Pharmaceutical Vehicles; Stomatitis, Aphthous; Tablets	2006
Effectiveness of two oral pastes for the treatment of recurrent aphthous stomatitis. Oral diseases, 2007, Volume: 13, Issue:5 Topics: Aminopyridines; Analysis of Variance; Anti-Allergic Agents; Anti-Inflammatory Agents; Clobetasol; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain Measurement; Stomatitis, Aphthous	2007
A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial. Trials, 2009, May-06, Volume: 10 Topics: Adhesiveness; Administration, Oral; Aminopyridines; Anti-Allergic Agents; China; Double-Blind Method; Drug Administration Schedule; Humans; Pain; Pain Measurement; Recurrence; Stomatitis, Aphthous; Tablets; Treatment Outcome	2009
Amlexanox is as effective as dexamethasone in topical treatment of erosive oral lichen planus: a short-term pilot study. Oral surgery, oral medicine, oral pathology and oral radiology, 2012, Volume: 113, Issue:5 Topics: Administration, Topical; Adult; Aged; Aminopyridines; Anti-Allergic Agents; Anti-Inflammatory Agents; Dexamethasone; Female; Humans; Lichen Planus, Oral; Male; Middle Aged; Pilot Projects; Prospective Studies; Statistics, Nonparametric; Treatment Outcome; Young Adult	2012
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nature communications, 2015, Jan-12, Volume: 6 Topics: 3T3-L1 Cells; Adipocytes; Adult; Aged; Aminopyridines; Animals; Cyclic AMP; Female; Gene Knockdown Techniques; Gluconeogenesis; Glucose-6-Phosphatase; Humans; Inflammation; Insulin Resistance; Interleukin-6; Liver; Male; Mice; Mice, Inbred C57BL; Middle Aged; p38 Mitogen-Activated Protein Kinases; Receptors, Adrenergic, beta; Signal Transduction; STAT3 Transcription Factor; Subcutaneous Fat; Young Adult	2015
Low-level laser therapy versus 5% amlexanox: a comparison of treatment effects in a cohort of patients with minor aphthous ulcers. Oral surgery, oral medicine, oral pathology and oral radiology, 2016, Volume: 121, Issue:3 Topics: Adolescent; Adult; Aminopyridines; Anti-Allergic Agents; Female; Humans; India; Low-Level Light Therapy; Male; Middle Aged; Pain Measurement; Stomatitis, Aphthous; Treatment Outcome	2016
Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell metabolism, 2017, Jul-05, Volume: 26, Issue:1 Topics: Aged; Aminopyridines; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Energy Metabolism; Female; Glycated Hemoglobin; Humans; I-kappa B Kinase; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Obesity; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases	2017

Other Studies

84 other study(ies) available for amlexanox and alpha-aminopyridine

Article	Year
Mechanism of nasal secretion mediated via nerve reflex in guinea pigs and evaluation of antiallergic drugs. International archives of allergy and immunology, 1992, Volume: 97, Issue:2 Topics: Allergens; Aminopyridines; Animals; Atropine Derivatives; Bronchodilator Agents; Capsaicin; Ganglionic Blockers; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; Histamine; Hypersensitivity; Lidocaine; Methacholine Chloride; Nasal Mucosa; ortho-Aminobenzoates; Parasympatholytics; Phthalazines; Pyrilamine; Reflex	1992
Effect of NZ-107, a newly synthesized pyridazinone derivative, on antigen-induced contraction of human bronchial strips and histamine release from human lung fragments or leukocytes. International archives of allergy and immunology, 1992, Volume: 98, Issue:1 Topics: Aminopyridines; Asthma; Bronchi; Bronchoconstriction; Cromolyn Sodium; Histamine; Histamine Release; Humans; In Vitro Techniques; Interleukin-3; Lung; Pyridazines; SRS-A	1992
Systemic contact dermatitis due to amlexanox. Contact dermatitis, 1992, Volume: 27, Issue:2 Topics: Adult; Aminopyridines; Dermatitis, Contact; Drug Eruptions; Female; Humans; Ophthalmic Solutions	1992
[Inhibitory effect of amlexanox on asthmatic attacks in an aspirin sensitive asthmatic]. Nihon Kyobu Shikkan Gakkai zasshi, 1992, Volume: 30, Issue:6 Topics: Adolescent; Aminopyridines; Aspirin; Asthma; Drug Hypersensitivity; Female; Humans; SRS-A	1992
Potent inhibitory activity of HSR-6071, a new antiallergic agent, on passive cutaneous anaphylaxis (PCA). Japanese journal of pharmacology, 1990, Volume: 52, Issue:1 Topics: Aminopyridines; Animals; Antigens; Ascaris; Azoles; Calcimycin; Cromolyn Sodium; Dinitrophenols; Guinea Pigs; Histamine Release; Ileum; Immunoglobulin E; Ketotifen; Male; Muscle Contraction; Muscle, Smooth; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Pyrrolidines; Rats; SRS-A; Tetrazoles	1990
[Inhibitory action amlexanox on interleukin-3-induced enhancement of histamine releasability of human leukocytes]. Arerugi = [Allergy], 1990, Volume: 39, Issue:10 Topics: Adult; Aminopyridines; Asthma; Drug Synergism; Female; Histamine Release; Humans; Immunoglobulin E; Interleukin-3; Leukocytes; Male; Recombinant Proteins; Rhinitis, Allergic, Perennial; SRS-A	1990
Inhibitory effect of levocabastine on experimental allergic conjunctivitis in guinea pigs. Journal of pharmacobio-dynamics, 1991, Volume: 14, Issue:8 Topics: Aminopyridines; Animals; Antigens; Capillary Permeability; Conjunctivitis, Allergic; Cromolyn Sodium; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; Histidine Decarboxylase; Male; Piperidines; SRS-A	1991
Allergic contact dermatitis from amlexanox (Elics) ophthalmic solution. Contact dermatitis, 1991, Volume: 24, Issue:2 Topics: Aged; Aminopyridines; Dermatitis, Contact; Drug Eruptions; Female; Humans; Male; Ophthalmic Solutions; SRS-A	1991
Contact dermatitis from amlexanox eyedrops. Contact dermatitis, 1991, Volume: 25, Issue:4 Topics: Administration, Topical; Adult; Aminopyridines; Dermatitis, Contact; Drug Eruptions; Eyelids; Facial Dermatoses; Female; Humans; Male; Middle Aged; Ophthalmic Solutions; Patch Tests	1991
Inhibitory effect of HSR-6071, a new anti-allergic agent, on experimental asthma in rats and guinea-pigs. The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:4 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Animals; Asthma; Azoles; Bronchi; Cromolyn Sodium; Female; Guinea Pigs; Histamine; Hypersensitivity; Immunoglobulin E; In Vitro Techniques; Ketotifen; Lung; Male; Muscle Relaxation; Muscle, Smooth; Passive Cutaneous Anaphylaxis; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains; SRS-A; Tetrazoles	1990
Pharmacodynamics of Amlexanox (AA-673) in normal and anaphylactic rat conjunctiva and its effect on histamine concentration. Ophthalmic research, 1990, Volume: 22, Issue:6 Topics: Aminopyridines; Animals; Chromatography, High Pressure Liquid; Conjunctiva; Dithiothreitol; Histamine; Hypersensitivity; Male; Ovalbumin; Rats; Rats, Inbred Strains	1990
[Effect of amlexanox on experimental allergic rhinitis in actively sensitized guinea pigs]. Arerugi = [Allergy], 1990, Volume: 39, Issue:1 Topics: Airway Resistance; Aminopyridines; Animals; Capillary Permeability; Guinea Pigs; Histamine; Immunization; Male; Nasal Mucosa; Rhinitis, Allergic, Perennial; SRS-A	1990
Inhibition by amoxanox (AA-673) of the immunologically, leukotriene D4- or platelet-activating factor-stimulated bronchoconstriction in guinea pigs and rats. International archives of allergy and applied immunology, 1985, Volume: 77, Issue:3 Topics: Aminopyridines; Animals; Asthma; Bronchi; Cromolyn Sodium; Epidermal Growth Factor; Female; Guinea Pigs; Histamine Release; Immunoglobulin E; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; SRS-A	1985
Mechanism of the action of amoxanox (AA-673), an orally active antiallergic agent. International archives of allergy and applied immunology, 1985, Volume: 78, Issue:1 Topics: Aminopyridines; Animals; Bronchial Spasm; Female; Guinea Pigs; Histamine Release; Immunoglobulin E; Ionophores; Leukotriene B4; Lung; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Rats; SRS-A	1985
Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase. International archives of allergy and applied immunology, 1987, Volume: 82, Issue:1 Topics: Aminopyridines; Animals; Cyclic AMP; Dinoprostone; Histamine Release; Isoproterenol; Macrophages; Male; Mast Cells; Peritoneal Cavity; Phosphoric Diester Hydrolases; Prostaglandins E; Rats; Rats, Inbred Strains; SRS-A	1987
[Effects of AA-673 on antigen-induced histamine release from leukocytes in patients with allergic rhinitis]. Arerugi = [Allergy], 1988, Volume: 37, Issue:11 Topics: Adolescent; Adult; Aminopyridines; Female; Histamine Release; Humans; Leukocytes; Male; Middle Aged; Rhinitis, Allergic, Seasonal; SRS-A	1988
[Inhibitory effect of amlexanox (AA-673) on the immunological and non-immunological release of histamine or leukotrienes]. Arerugi = [Allergy], 1989, Volume: 38, Issue:11 Topics: Aminopyridines; Benzoquinones; Cells, Cultured; Dose-Response Relationship, Drug; Histamine Release; Humans; Hypersensitivity, Immediate; In Vitro Techniques; Leukocytes; Leukotrienes; Lung; ortho-Aminobenzoates; Quinones	1989
[Influences of anti-allergic drugs on superoxide generation from the hypoxanthine-xanthine oxidase system or polymorphonuclear leukocytes]. Arerugi = [Allergy], 1989, Volume: 38, Issue:6 Topics: Aminopyridines; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Free Radicals; Histamine H1 Antagonists; Humans; Neutrophils; Phenothiazines; Phthalazines; Pyridazines; Superoxide Dismutase; Superoxides	1989
The antiallergic agent amoxanox suppresses SRS-A generation by inhibiting lipoxygenase. International archives of allergy and applied immunology, 1986, Volume: 79, Issue:3 Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Aminopyridines; Animals; Asthma; Calcimycin; Cattle; Guinea Pigs; Histamine H1 Antagonists; Hydroxyeicosatetraenoic Acids; Hypersensitivity; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Male; Monocytes; Prostaglandins; Rats; Rats, Inbred Strains; SRS-A; Thromboxane B2	1986
[Intraocular tissue accumulation during and after consecutive instillation of 1.0% AA-673 anti-allergic agent ophthalmic solution for 21 days in rabbit eyes]. Nippon Ganka Gakkai zasshi, 1988, Volume: 92, Issue:7 Topics: Aminopyridines; Animals; Eye; Instillation, Drug; Male; Metabolic Clearance Rate; Ophthalmic Solutions; Rabbits; SRS-A; Tissue Distribution	1988
Synthesis of the metabolites and degradation products of 2-amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3- carboxylic acid (Amoxanox). Chemical & pharmaceutical bulletin, 1985, Volume: 33, Issue:10 Topics: Aminopyridines; Animals; Asthma; Biotransformation; Passive Cutaneous Anaphylaxis; Rats	1985
Allergenicity and tolerogenicity of amlexanox in the guinea pig. Contact dermatitis, 1994, Volume: 31, Issue:1 Topics: Administration, Oral; Administration, Topical; Allergens; Aminopyridines; Animals; Anti-Inflammatory Agents; Dermatitis, Allergic Contact; Drug Eruptions; Drug Hypersensitivity; Female; Guinea Pigs; Immunization; Patch Tests	1994
Role of mast cells, eosinophils and IL-5 in the development of airway hyperresponsiveness in sensitized mice. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1996, Volume: 26, Issue:6 Topics: Aminopyridines; Animals; Anti-Allergic Agents; Antibodies, Monoclonal; Bronchial Hyperreactivity; Chromones; Eosinophils; Interleukin-5; Ketotifen; Male; Mast Cells; Mice; Mice, Inbred BALB C; Prodrugs	1996
Two distinct anti-allergic drugs, amlexanox and cromolyn, bind to the same kinds of calcium binding proteins, except calmodulin, in bovine lung extract. Biochemical and biophysical research communications, 1997, Nov-17, Volume: 240, Issue:2 Topics: Amino Acid Sequence; Aminopyridines; Animals; Annexins; Anti-Allergic Agents; Binding Sites; Calcium-Binding Proteins; Calgranulin B; Calmodulin; Cattle; Chromatography, Affinity; Chromatography, High Pressure Liquid; Cromolyn Sodium; Lung; Molecular Sequence Data; Molecular Weight; Peptide Fragments; S100 Proteins; S100A12 Protein; Sequence Alignment; Sequence Homology, Amino Acid	1997
S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro. The Journal of biological chemistry, 1998, Aug-28, Volume: 273, Issue:35 Topics: Administration, Topical; Aminopyridines; Animals; Anti-Inflammatory Agents; Brain; Calcium-Binding Proteins; Fibroblast Growth Factors; Heat-Shock Response; Histamine H1 Antagonists; Membrane Glycoproteins; Nerve Tissue Proteins; Protein Denaturation; S100 Proteins; Sheep; Synaptotagmin I; Synaptotagmins	1998
Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. The Biochemical journal, 1999, Mar-15, Volume: 338 ( Pt 3) Topics: Amino Acid Sequence; Aminopyridines; Animals; Anti-Allergic Agents; Base Sequence; Calcium-Binding Proteins; Cattle; Chromatography, Affinity; Chromatography, High Pressure Liquid; Cromolyn Sodium; DNA, Complementary; Humans; Molecular Sequence Data; Molecular Weight; ortho-Aminobenzoates; Protein Binding; Recombinant Proteins; S100 Proteins; S100A12 Protein	1999
Purification of bovine S100A12 from recombinant Escherichia coli. Protein expression and purification, 1999, Volume: 16, Issue:1 Topics: Amino Acid Sequence; Aminopyridines; Animals; Anti-Allergic Agents; Base Sequence; Calcium-Binding Proteins; Cattle; Chromatography, Affinity; DNA Primers; Escherichia coli; In Vitro Techniques; Lung; Molecular Sequence Data; Recombinant Proteins; S100 Proteins; S100A12 Protein	1999
[Changes in isolated ciliary muscle caused by repeated instillation of carbachol ointment in rabbits and effect of topically applied amlexanox]. Nippon Ganka Gakkai zasshi, 2000, Volume: 104, Issue:1 Topics: Administration, Topical; Aminopyridines; Animals; Carbachol; Cholinergic Agonists; Ciliary Body; In Vitro Techniques; Miotics; Muscle Contraction; Ointments; Ophthalmic Solutions; Rabbits	2000
Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in vitro. The Journal of biological chemistry, 2000, Oct-20, Volume: 275, Issue:42 Topics: 3T3 Cells; Actins; Aminopyridines; Animals; Anti-Inflammatory Agents; Aorta; Apoptosis; Cell Division; Cell Movement; Cortactin; Cytoskeleton; Endothelium, Vascular; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Genes, src; Humans; L Cells; Mice; Microfilament Proteins; Muscle, Smooth, Vascular; Phosphorylation; Rats; Receptors, Cell Surface; Steroids; Transfection; Umbilical Veins; Xenopus laevis	2000
The precursor but not the mature form of IL1alpha blocks the release of FGF1 in response to heat shock. The Journal of biological chemistry, 2001, Feb-16, Volume: 276, Issue:7 Topics: 3T3 Cells; Aminopyridines; Animals; Brefeldin A; Calcium-Binding Proteins; Deoxyglucose; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Heat-Shock Response; Interleukin-1; Kinetics; Membrane Glycoproteins; Mice; Nerve Tissue Proteins; Protein Precursors; Protein Transport; Sequence Deletion; Synaptotagmin I; Synaptotagmins; Transfection	2001
Inhibitory effects of amlexanox on carbachol-induced contractions of rabbit ciliary muscle and guinea-pig taenia caecum. The Journal of pharmacy and pharmacology, 2000, Volume: 52, Issue:11 Topics: Aminopyridines; Animals; Anti-Allergic Agents; Calcium; Carbachol; Cecum; Cholinergic Agonists; Ciliary Body; Cyclic AMP; Dose-Response Relationship, Drug; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Myopia; Myosin-Light-Chain Kinase; Phosphorylation; Rabbits	2000
The comparative release of FGF1 by hypoxia and temperature stress. Growth factors (Chur, Switzerland), 2001, Volume: 18, Issue:4 Topics: 3T3 Cells; 5,8,11,14-Eicosatetraynoic Acid; Aminopyridines; Animals; Arachidonic Acid; Calcium-Binding Proteins; Cell Hypoxia; Cell Line; Cyclooxygenase Inhibitors; Cysteine; Dimerization; Fibroblast Growth Factor 1; Humans; Lipoxygenase Inhibitors; Macromolecular Substances; Membrane Glycoproteins; Mice; Nerve Tissue Proteins; Nitrobenzenes; Stress, Physiological; Sulfonamides; Synaptotagmin I; Synaptotagmins; Temperature; Transfection	2001
Interaction of S100 proteins with the antiallergic drugs, olopatadine, amlexanox, and cromolyn: identification of putative drug binding sites on S100A1 protein. Biochemical and biophysical research communications, 2002, Apr-12, Volume: 292, Issue:4 Topics: Aminopyridines; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Binding Sites; Binding, Competitive; Blotting, Western; Calcium; Calcium-Binding Proteins; Calmodulin; Cattle; Chromatography, Affinity; Cromolyn Sodium; Dibenzoxepins; Dimerization; Fluphenazine; Ligands; Mutagenesis, Site-Directed; Olopatadine Hydrochloride; Protein Binding; Protein Conformation; S100 Proteins; Sepharose; Substrate Specificity; Tissue Extracts	2002
Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. The Biochemical journal, 2003, Sep-01, Volume: 374, Issue:Pt 2 Topics: Amino Acid Sequence; Aminopyridines; Animals; Anti-Allergic Agents; Binding Sites; Brain Chemistry; Carrier Proteins; Cattle; Cromolyn Sodium; Cyclophilins; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Macromolecular Substances; Molecular Sequence Data; Peptide Fragments; Peptidyl-Prolyl Isomerase F; Peptidylprolyl Isomerase; Protein Binding; Protein Folding; Protein Structure, Tertiary; Rats; Receptors, Drug; Sequence Deletion; Signal Transduction	2003
Molecular mechanism of inhibition of nonclassical FGF-1 export. Biochemistry, 2005, Nov-29, Volume: 44, Issue:47 Topics: Aminopyridines; Anti-Allergic Agents; Binding Sites; Computer Simulation; Copper; Fibroblast Growth Factor 1; Hot Temperature; Humans; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Protein Binding; Protein Denaturation; Protein Transport	2005
Voltage-dependent N-type Ca2+ channel activity regulates the interaction between FGF-1 and S100A13 for stress-induced non-vesicular release. Cellular and molecular neurobiology, 2006, Volume: 26, Issue:3 Topics: Aminopyridines; Animals; Anti-Allergic Agents; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Cell Line; Chelating Agents; Egtazic Acid; Exocytosis; Fibroblast Growth Factor 1; Fluorescence Resonance Energy Transfer; Luminescent Proteins; omega-Conotoxin GVIA; Oxidative Stress; Rats; S100 Proteins; Secretory Vesicles	2006
Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein. Mediators of inflammation, 2006, Volume: 2006, Issue:1 Topics: Aminopyridines; Cell Culture Techniques; Cell Movement; Dibenzoxepins; Gene Expression Regulation; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Inflammation; Ketotifen; Monocytes; Olopatadine Hydrochloride; Receptors, Histamine H1; S100 Proteins; S100A12 Protein	2006
A late cutaneous response in actively sensitized rats: a new method for evaluating the efficacy of antiallergic drugs. Journal of pharmacological sciences, 2006, Volume: 101, Issue:4 Topics: Aminopyridines; Animals; Anti-Allergic Agents; Antigens; Cromolyn Sodium; Cyclosporine; Dinitrobenzenes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Edema; Haptens; Hindlimb; Hypersensitivity, Delayed; Male; ortho-Aminobenzoates; Ovalbumin; Passive Cutaneous Anaphylaxis; Promethazine; Pyridines; Pyrimidinones; Quinolones; Rats; Rats, Wistar	2006
Synergistic Ca2+ and Cu2+ requirements of the FGF1-S100A13 interaction measured by quartz crystal microbalance: an initial step in amlexanox-reversible non-classical release of FGF1. Neurochemistry international, 2008, Volume: 52, Issue:6 Topics: Aminopyridines; Animals; Anti-Allergic Agents; Binding Sites; Binding, Competitive; Biological Assay; Calcium; Calcium Signaling; Copper; Dose-Response Relationship, Drug; Fibroblast Growth Factor 1; Humans; Kinetics; Molecular Weight; Neurochemistry; Quartz; S100 Proteins	2008
[Local Treatment of stomatitis aphthosa]. Medizinische Monatsschrift fur Pharmazeuten, 2008, Volume: 31, Issue:9 Topics: Administration, Topical; Aminopyridines; Anti-Allergic Agents; Humans; Stomatitis, Aphthous	2008
Molecular level interactions of S100A13 with amlexanox: inhibitor for formation of the multiprotein complex in the nonclassical pathway of acidic fibroblast growth factor. Biochemistry, 2010, Mar-23, Volume: 49, Issue:11 Topics: Aminopyridines; Binding Sites; Calorimetry; Fibroblast Growth Factor 1; Humans; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Multimerization; Protein Stability; Protein Structure, Quaternary; S100 Proteins; Solutions; Spectrometry, Fluorescence	2010
Rescue of nonsense mutations by amlexanox in human cells. Orphanet journal of rare diseases, 2012, Aug-31, Volume: 7 Topics: Aminopyridines; Blotting, Western; Cell Line; Cell Survival; Codon, Nonsense; Cystic Fibrosis Transmembrane Conductance Regulator; Fluorescent Antibody Technique; HeLa Cells; Humans; Nonsense Mediated mRNA Decay; Protein Binding	2012
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nature medicine, 2013, Volume: 19, Issue:3 Topics: Aminopyridines; Animals; Anti-Allergic Agents; Anti-Obesity Agents; Cell Line; Diet, High-Fat; Energy Metabolism; Enzyme Activation; Fatty Liver; Glucose Metabolism Disorders; I-kappa B Kinase; Insulin Resistance; Intra-Abdominal Fat; Male; Mice; Mice, Inbred C57BL; Mice, Obese; NF-kappa B; Obesity; Oxygen Consumption; Protein Serine-Threonine Kinases; Weight Loss	2013
Turning off the inflammatory, but not the metabolic, flames. Nature medicine, 2013, Volume: 19, Issue:3 Topics: Aminopyridines; Animals; Anti-Obesity Agents; Energy Metabolism; I-kappa B Kinase; Insulin Resistance; Male; Obesity; Protein Serine-Threonine Kinases	2013
Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1. eLife, 2013, Dec-24, Volume: 2 Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue, White; Adrenergic beta-3 Receptor Agonists; Aminopyridines; Animals; Catecholamines; Chlorocebus aethiops; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Dioxoles; Disease Models, Animal; Energy Metabolism; Enzyme Activation; HEK293 Cells; Humans; I-kappa B Kinase; Inflammation; Ion Channels; Lipolysis; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Obesity; Phosphorylation; Poly I-C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Receptors, Adrenergic, beta; Signal Transduction; Sterol Esterase; Time Factors; Transfection; Tumor Necrosis Factor-alpha; Uncoupling Protein 1	2013
Determinants, outcomes and costs of ceftriaxone v. amoxicillin-clavulanate in the treatment of community-acquired pneumonia at Witbank Hospital. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2014, Volume: 104, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminopyridines; Ceftriaxone; Clavulanic Acid; Community-Acquired Infections; Drug Combinations; Female; Humans; Length of Stay; Male; Middle Aged; Pneumonia; Sex Factors; Treatment Outcome	2014
Identification and characterization of amlexanox as a G protein-coupled receptor kinase 5 inhibitor. Molecules (Basel, Switzerland), 2014, Oct-22, Volume: 19, Issue:10 Topics: Aminopyridines; Animals; Animals, Newborn; Anti-Allergic Agents; Cattle; Cells, Cultured; Crystallography, X-Ray; Drug Discovery; G-Protein-Coupled Receptor Kinase 1; G-Protein-Coupled Receptor Kinase 5; High-Throughput Screening Assays; Humans; Kinetics; Models, Molecular; Protein Kinase Inhibitors; Rats; Small Molecule Libraries; Structure-Activity Relationship	2014
Poly I:C enhances production of nitric oxide in response to interferon-γ via upregulation of interferon regulatory factor 7 in vascular endothelial cells. Microvascular research, 2015, Volume: 98 Topics: Aminopyridines; Animals; Aorta; Cell Line; Cell Proliferation; Endothelial Cells; Enzyme Inhibitors; Flow Cytometry; Gene Expression Regulation; Interferon Regulatory Factor-3; Interferon Regulatory Factor-7; Interferon-gamma; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Phosphorylation; Poly I-C; Signal Transduction	2015
Micelle-enhanced spectrofluorimetric determination of amlexanox in bioadhesive buccal tablets: application to content uniformity testing. Luminescence : the journal of biological and chemical luminescence, 2015, Volume: 30, Issue:6 Topics: Administration, Buccal; Aminopyridines; Hydrogen-Ion Concentration; Limit of Detection; Micelles; Reproducibility of Results; Sensitivity and Specificity; Sodium Dodecyl Sulfate; Solvents; Spectrometry, Fluorescence; Tablets; Temperature	2015
Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss. Scientific reports, 2015, Sep-04, Volume: 5 Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Bone Density Conservation Agents; Cell Differentiation; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred C57BL; Osteoclasts; Osteoporosis; Ovariectomy; Treatment Outcome	2015
The protein kinase IKKepsilon contributes to tumour growth and tumour pain in a melanoma model. Biochemical pharmacology, 2016, Mar-01, Volume: 103 Topics: Aminopyridines; Animals; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; Humans; I-kappa B Kinase; Melanocytes; Melanoma; Melanoma, Experimental; Mice, Inbred C57BL; Mice, Knockout; Pain; Skin Neoplasms	2016
Low-level laser therapy versus 5% amlexanox: a comparison of treatment effects in a cohort of minor aphthous ulcers patients-a commentary. Oral surgery, oral medicine, oral pathology and oral radiology, 2016, Volume: 122, Issue:3 Topics: Aminopyridines; Humans; Low-Level Light Therapy; Pain Measurement; Recurrence; Stomatitis, Aphthous	2016
Amlexanox Blocks the Interaction between S100A4 and Epidermal Growth Factor and Inhibits Cell Proliferation. PloS one, 2016, Volume: 11, Issue:8 Topics: Aminopyridines; Anti-Allergic Agents; Anti-Inflammatory Agents; Calcium; Cell Differentiation; Cell Proliferation; Cell Survival; Epidermal Growth Factor; Fluorescence; Humans; Ligands; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Mutation; Protein Binding; Protein Conformation; S100 Calcium-Binding Protein A4; Signal Transduction; Trypsin	2016
Chronic ethanol consumption: role of TLR3/TRIF-dependent signaling. Addiction biology, 2018, Volume: 23, Issue:3 Topics: Adaptor Proteins, Vesicular Transport; Aminopyridines; Amygdala; Animals; Brain; Central Nervous System Depressants; Chemokine CXCL10; Ethanol; I-kappa B Kinase; Lipopolysaccharide Receptors; Mice; Mice, Inbred C57BL; Neuroimmunomodulation; Nucleus Accumbens; Prefrontal Cortex; Protein Serine-Threonine Kinases; RNA, Messenger; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 3; Toll-Like Receptor 4	2018
Amlexanox, a selective inhibitor of IKBKE, generates anti-tumoral effects by disrupting the Hippo pathway in human glioblastoma cell lines. Cell death & disease, 2017, 08-31, Volume: 8, Issue:8 Topics: Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Hippo Signaling Pathway; Humans; I-kappa B Kinase; Mice; Mice, Nude; Neoplasm Invasiveness; Protein Serine-Threonine Kinases; Proteolysis; Signal Transduction; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays	2017
Amlexanox provides a potential therapy for nonsense mutations in the lysosomal storage disorder Aspartylglucosaminuria. Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:3 Topics: Amino Acid Substitution; Aminopyridines; Aspartylglucosaminuria; Aspartylglucosylaminase; Cells, Cultured; Child; Codon, Nonsense; Female; HEK293 Cells; HeLa Cells; Humans; Lysosomal Storage Diseases; Mutation, Missense	2018
Amlexanox Inhibits Cerebral Ischemia-Induced Delayed Astrocytic High-Mobility Group Box 1 Release and Subsequent Brain Damage. The Journal of pharmacology and experimental therapeutics, 2018, Volume: 365, Issue:1 Topics: Aminopyridines; Animals; Astrocytes; Brain; Brain Ischemia; Gene Expression Regulation; HMGB1 Protein; Male; Mice; Mice, Inbred C57BL; Microglia; Neurons	2018
Targeting IRF3 as a YAP agonist therapy against gastric cancer. The Journal of experimental medicine, 2018, 02-05, Volume: 215, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Aminopyridines; Animals; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; DNA-Binding Proteins; Female; Genome-Wide Association Study; HEK293 Cells; Humans; Interferon Regulatory Factor-3; Male; Mice, Inbred C57BL; Middle Aged; Molecular Targeted Therapy; Muscle Proteins; Phosphoproteins; Protein Binding; RNA, Messenger; Signal Transduction; Stomach Neoplasms; TEA Domain Transcription Factors; Transcription Factors; Viruses; YAP-Signaling Proteins	2018
IKKε aggravates inflammatory response via activation of NF-κB in rheumatoid arthritis. European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:7 Topics: Aminopyridines; Animals; Arthritis, Experimental; I-kappa B Kinase; Inflammation Mediators; Male; Mice; Mice, Knockout; NF-kappa B; Pain	2018
Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction. Molecular metabolism, 2018, Volume: 16 Topics: Aminopyridines; Animals; Body Weight; Diet, High-Fat; Disease Models, Animal; Fatty Liver; I-kappa B Kinase; Insulin; Insulin Resistance; Male; Metabolic Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Weight Loss	2018
Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKK Molecular pharmacology, 2018, Volume: 94, Issue:4 Topics: 3T3-L1 Cells; Adipocytes; Aminopyridines; Animals; Carboxylic Acids; Cell Line; Diabetes Mellitus, Type 2; Energy Metabolism; Humans; I-kappa B Kinase; Inflammation; Mice; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Structure-Activity Relationship	2018
Inhibition of the protein kinase IKKepsilon attenuates neuropathic pain in mice. Neuropharmacology, 2019, 03-01, Volume: 146 Topics: Aminopyridines; Animals; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; I-kappa B Kinase; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Neuralgia; NF-kappa B; Peripheral Nerve Injuries; Protein Serine-Threonine Kinases; Sciatic Nerve; Signal Transduction; Spinal Cord	2019
Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer. Cancer letters, 2019, 05-28, Volume: 450 Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Docetaxel; Drug Synergism; Female; Humans; I-kappa B Kinase; Mammary Neoplasms, Experimental; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Protein Serine-Threonine Kinases; RAW 264.7 Cells	2019
Amlexanox attenuates experimental autoimmune encephalomyelitis by inhibiting dendritic cell maturation and reprogramming effector and regulatory T cell responses. Journal of neuroinflammation, 2019, Mar-01, Volume: 16, Issue:1 Topics: Aminopyridines; Animals; Cell Differentiation; Dendritic Cells; Encephalomyelitis, Autoimmune, Experimental; Interferon Regulatory Factor-3; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; T-Lymphocytes; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells	2019
Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat, and human microsomes. Journal of labelled compounds & radiopharmaceuticals, 2019, 05-15, Volume: 62, Issue:5 Topics: Aminopyridines; Animals; Chemistry Techniques, Synthetic; Deuterium; Drug Stability; Humans; Isotope Labeling; Kinetics; Mice; Microsomes; Protein Serine-Threonine Kinases; Rats	2019
Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor. Frontiers in immunology, 2019, Volume: 10 Topics: Allergens; Aminopyridines; Animals; Asthma; Bronchoalveolar Lavage Fluid; Eosinophils; Female; Immunoglobulin E; Immunoglobulin G; Interleukin-33; Lung; Mice; Mice, Inbred C57BL; Nucleotides, Cyclic; Protein Serine-Threonine Kinases; Pulmonary Eosinophilia; Pyroglyphidae; Signal Transduction	2019
Amlexanox reversed non-alcoholic fatty liver disease through IKKε inhibition of hepatic stellate cell. Life sciences, 2019, Dec-15, Volume: 239 Topics: Actins; Aminopyridines; Animals; Body Weight; Energy Metabolism; Gene Expression; Glucose; Hepatic Stellate Cells; Hepatocytes; I-kappa B Kinase; Insulin; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Signal Transduction	2019
GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-κB Signaling. Arthritis & rheumatology (Hoboken, N.J.), 2020, Volume: 72, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminopyridines; Animals; Cartilage, Articular; Chondrocytes; Enzyme Inhibitors; Female; G-Protein-Coupled Receptor Kinase 5; Gene Expression Regulation; Humans; Knee Joint; Male; Mice; Mice, Knockout; Middle Aged; NF-kappa B; NF-KappaB Inhibitor alpha; Osteoarthritis, Knee; Phosphorylation; RNA, Small Interfering; Signal Transduction; Young Adult	2020
Amlexanox ameliorates acetaminophen-induced acute liver injury by reducing oxidative stress in mice. Toxicology and applied pharmacology, 2019, 12-15, Volume: 385 Topics: Acetaminophen; Acute Lung Injury; Aminopyridines; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; I-kappa B Kinase; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Protein Serine-Threonine Kinases	2019
Dual TBK1/IKKɛ inhibitor amlexanox attenuates the severity of hepatotoxin-induced liver fibrosis and biliary fibrosis in mice. Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:2 Topics: Aminopyridines; Animals; Bile Ducts; Carbon Tetrachloride; Hepatic Stellate Cells; I-kappa B Kinase; Inflammation; Kupffer Cells; Liver Cirrhosis; Male; Mice, Inbred C57BL; Protein Serine-Threonine Kinases; Severity of Illness Index; STAT3 Transcription Factor	2020
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. EMBO molecular medicine, 2020, 02-07, Volume: 12, Issue:2 Topics: Aminopyridines; Animals; Breast Neoplasms; Culture Media, Conditioned; Epithelial Cells; Female; Humans; I-kappa B Kinase; Inflammation; Macrophages; Mammary Glands, Human; Mice; Obesity; Protein Serine-Threonine Kinases; Serine	2020
Amlexanox exerts anti-inflammatory actions by targeting phosphodiesterase 4B in lipopolysaccharide-activated macrophages. Biochimica et biophysica acta. Molecular cell research, 2020, Volume: 1867, Issue:10 Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Inflammation; Interleukin-10; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred ICR; Milrinone; NF-kappa B; Nitric Oxide; RAW 264.7 Cells; Signal Transduction; Spectrometry, Fluorescence; Transcription Factor AP-1; Tumor Necrosis Factor-alpha	2020
The Specific IKKε/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-κB and MAP Kinase Pathways. International journal of molecular sciences, 2020, Jul-02, Volume: 21, Issue:13 Topics: Aminopyridines; Animals; Autophagy; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; I-kappa B Kinase; Melanoma; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; NF-kappa B; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Xenograft Model Antitumor Assays	2020
Inhibition of TBK1 by amlexanox attenuates paraquat-induced acute lung injury. Toxicology, 2020, Volume: 443 Topics: Acute Lung Injury; Aminopyridines; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cell Survival; Herbicides; Interferon Regulatory Factor-3; Interferon-beta; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Paraquat; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; RAW 264.7 Cells; Transcription Factor RelA	2020
Long-term subcutaneous injection of lipopolysaccharides and high-fat diet induced non-alcoholic fatty liver disease through IKKε/ NF-κB signaling. Biochemical and biophysical research communications, 2020, 11-12, Volume: 532, Issue:3 Topics: Aminopyridines; Animals; Diet, High-Fat; Disease Models, Animal; Gene Expression; I-kappa B Kinase; Injections, Subcutaneous; Lipid Metabolism; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Protein Kinase Inhibitors; Signal Transduction	2020
Multiple pathways of type 1 interferon production in lupus: the case for amlexanox. Rheumatology (Oxford, England), 2020, 12-01, Volume: 59, Issue:12 Topics: A549 Cells; Aminopyridines; Animals; Humans; Interferon Type I; Lupus Erythematosus, Systemic; Metabolic Networks and Pathways	2020
Dual TBK1/IKKε inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro. Toxicology, 2020, Volume: 444 Topics: Aminopyridines; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Coculture Techniques; Cytokines; Hepatocytes; I-kappa B Kinase; Interferon Regulatory Factor-3; Kupffer Cells; Lipid Metabolism; Male; Mice, Inbred C57BL; NF-kappa B; Palmitic Acid; Protein Serine-Threonine Kinases	2020
T-Cell Activation-Inhibitory Assay to Screen Caloric Restriction Mimetics Drugs for Drug Repositioning. Biological & pharmaceutical bulletin, 2021, Volume: 44, Issue:4 Topics: Aminopyridines; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Caloric Restriction; Cell Survival; Cyclooxygenase 2; Dibenzazepines; Drug Repositioning; Female; Imidazoles; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Pyridines; RAW 264.7 Cells; Spleen; T-Lymphocytes; Tumor Necrosis Factor-alpha	2021
FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition. The Journal of clinical investigation, 2021, 05-17, Volume: 131, Issue:10 Topics: Aminopyridines; Animals; Blood Glucose; Eating; Energy Metabolism; Fibroblast Growth Factors; Gluconeogenesis; I-kappa B Kinase; Interleukin-6; Liver; Mice; Mice, Knockout; Protein Serine-Threonine Kinases; STAT3 Transcription Factor	2021
Amlexanox enhances the antitumor effect of anti-PD-1 antibody. Biochemical and biophysical research communications, 2021, 06-30, Volume: 560 Topics: Aminopyridines; Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Cell Line, Tumor; Dendritic Cells; Female; Humans; Interferon-gamma; Jurkat Cells; Lymphocyte Culture Test, Mixed; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasms, Experimental; Programmed Cell Death 1 Receptor; T-Lymphocytes, Cytotoxic	2021
A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation. British journal of pharmacology, 2021, Volume: 178, Issue:19 Topics: Aminopyridines; Animals; beta Catenin; Lung; Mice; Mice, Inbred C57BL; Organoids; Pharmaceutical Preparations; Wnt Signaling Pathway	2021
Translational readthrough of ciliopathy genes BBS2 and ALMS1 restores protein, ciliogenesis and function in patient fibroblasts. EBioMedicine, 2021, Volume: 70 Topics: Adolescent; Adult; Alstrom Syndrome; Aminopyridines; Bardet-Biedl Syndrome; Cell Cycle Proteins; Cells, Cultured; Codon, Nonsense; Fibroblasts; Humans; Male; Oxadiazoles; Proteins; Receptors, Somatostatin; Tumor Suppressor Proteins	2021
The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis. JCI insight, 2022, 09-08, Volume: 7, Issue:17 Topics: Aminopyridines; Animals; Atherosclerosis; Bile Acids and Salts; Diabetes Mellitus, Experimental; Humans; Hypercholesterolemia; I-kappa B Kinase; Mice; Protein Serine-Threonine Kinases	2022
Amlexanox-modified platinum(IV) complex triggers apoptotic and autophagic bimodal death of cancer cells. European journal of medicinal chemistry, 2022, Nov-15, Volume: 242 Topics: Aminopyridines; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Cell Line, Tumor; Cisplatin; Cytochromes c; DNA; Humans; Microtubule-Associated Proteins; Neoplasms; Platinum; Prodrugs	2022