amitriptyline and yohimbine

amitriptyline has been researched along with yohimbine in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199014 (58.33)18.7374
1990's4 (16.67)18.2507
2000's3 (12.50)29.6817
2010's2 (8.33)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Andrews, PR; Craik, DJ; Martin, JL1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Bandyopadhyaya, A; Rajagopalan, DR; Rajagopalan, P; Rajagopalan, R1
Agrawal, DK; Andersen, JM; Bhatia, SC; Hsieh, HH; Theesen, KA; Townley, RG; Weiss, S1
Deighton, NM; Hamilton, CA; Reid, JL; Yakubu, MA1
Davidson, RK; Dilsaver, SC1
Kaada, B1
Barr, SM; Hamilton, CA; Reid, JL1
Convery, ME; Domino, EF; Selden, EM; Stites, MM1
Braddock, L; Cowen, PJ; Elliott, JM; Fraser, S; Stump, K1
Adithan, C; Bapna, JS; Shashindran, CH; Sivagnanam, G; Swain, R1
Chang, RS; Kling, P; Lotti, VJ1
García-Sevilla, JA; Hollingsworth, PJ; Smnith, CB1
Bradley, L; Doggrell, SA1
Braddock, LE; Cowen, PJ; Elliott, JM; Fraser, S; Stump, K1
Bagheri, H; Berlan, M; Houin, G; Montastruc, JL; Picault, P; Schmitt, L1
Cai, B; Matsumoto, K; Ohta, H; Watanabe, H1
Bartolini, A; Galeotti, N; Ghelardini, C1
QUINTON, RM1
HALLIWELL, G; QUINTON, RM; WILLIAMS, FE1
Pettersen, VL; Raimundo, JM; Sudo, RT; Trachez, MM; Zapata-Sudo, G1
Chen, H; Chen, SR; Huang, Y; Pan, HL1

Trials

2 trial(s) available for amitriptyline and yohimbine

ArticleYear
Platelet alpha-2 adrenoreceptor activity pre-treatment and post-treatment in major depressive disorder with melancholia.
    Research communications in chemical pathology and pharmacology, 1991, Volume: 74, Issue:1

    Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Blood Platelets; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Receptors, Adrenergic, alpha; Yohimbine

1991
Pharmacokinetic study of yohimbine and its pharmacodynamic effects on salivary secretion in patients treated with tricyclic antidepressants.
    British journal of clinical pharmacology, 1994, Volume: 37, Issue:1

    Topics: Administration, Oral; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Double-Blind Method; Drug Interactions; Female; Humans; Male; Middle Aged; Norepinephrine; Salivation; Yohimbine

1994

Other Studies

22 other study(ies) available for amitriptyline and yohimbine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.
    Bioorganic & medicinal chemistry letters, 2014, Jan-15, Volume: 24, Issue:2

    Topics: Benzodiazepinones; Isomerism; Protein Binding; Protein Structure, Tertiary; Receptors, Cell Surface

2014
Differences in the regulation of [3H]idazoxan and [3H]yohimbine binding sites in the rabbit.
    European journal of pharmacology, 1990, Feb-13, Volume: 176, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amitriptyline; Animals; Binding Sites; Brain Chemistry; Dioxanes; Dioxins; Hindlimb; Idazoxan; In Vitro Techniques; Kidney; Kinetics; Norepinephrine; Rabbits; Yohimbine

1990
Chronic treatment with amitriptyline produces subsensitivity to the hypothermic effects of yohimbine.
    Progress in neuro-psychopharmacology & biological psychiatry, 1989, Volume: 13, Issue:1-2

    Topics: Amitriptyline; Animals; Body Temperature; Drug Synergism; Hypothermia; Male; Rats; Rats, Inbred Strains; Reference Values; Yohimbine

1989
Neurotransmitters in "the smoke reflex" in rabbits.
    General pharmacology, 1987, Volume: 18, Issue:1

    Topics: Amitriptyline; Animals; Atropine; Clonidine; Heart Rate; Neurotransmitter Agents; Nicotiana; Norepinephrine; Plants, Toxic; Rabbits; Reflex; Smoke; Yohimbine

1987
Long-term amitriptyline treatment alters the affinity state of alpha 2 adrenoceptors in rabbit hindbrain.
    Life sciences, 1986, Jun-30, Volume: 38, Issue:26

    Topics: Amitriptyline; Animals; Blood Pressure; Body Weight; Brain Stem; Cerebellum; Clonidine; Dioxanes; Epinephrine; Heart Rate; Idazoxan; Male; Rabbits; Receptors, Adrenergic, alpha; Yohimbine

1986
Pharmacologic evidence that high dose chronic amitriptyline and desipramine down-regulate alpha 2-receptor-mediated hypothermia in the rat.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 281, Issue:2

    Topics: Amitriptyline; Animals; Body Temperature Regulation; Chromatography, High Pressure Liquid; Clonidine; Desipramine; Half-Life; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine

1986
Binding of yohimbine and imipramine to platelets in depressive illness.
    Psychological medicine, 1986, Volume: 16, Issue:4

    Topics: Adult; Aged; Amitriptyline; Blood Platelets; Depressive Disorder; Dexamethasone; Electroconvulsive Therapy; Female; Humans; Hydrocortisone; Imipramine; Male; Middle Aged; Psychological Tests; Receptors, Adrenergic, alpha; Receptors, Serotonin; Yohimbine

1986
Potentiation of clonidine analgesia by amitriptyline.
    Indian journal of experimental biology, 1986, Volume: 24, Issue:4

    Topics: Amitriptyline; Analgesia; Animals; Clonidine; Drug Synergism; Male; Mice; Naloxone; Yohimbine

1986
Pre- and postsynaptic adrenergic activation by norepinephrine reuptake inhibitors in the field-stimulated rat vas deferens.
    Life sciences, 1981, Aug-10, Volume: 29, Issue:6

    Topics: Amitriptyline; Animals; Chlorpromazine; Cocaine; Desipramine; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Male; Norepinephrine; Prazosin; Protriptyline; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Vas Deferens; Yohimbine

1981
Alpha 2-adrenoreceptors on human platelets: selective labelling by [3H]clonidine and [3H]yohimbine and competitive inhibition by antidepressant drugs.
    European journal of pharmacology, 1981, Sep-24, Volume: 74, Issue:4

    Topics: Adult; Amitriptyline; Antidepressive Agents; Binding, Competitive; Blood Platelets; Cell Membrane; Clonidine; Desipramine; Humans; In Vitro Techniques; Iprindole; Kinetics; Male; Mianserin; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Yohimbine

1981
Effects of amitriptyline, desipramine and mianserin on noradrenergic transmission in the rat isolated right ventricle.
    Journal of autonomic pharmacology, 1983, Volume: 3, Issue:4

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Electric Stimulation; Heart; In Vitro Techniques; Male; Mianserin; Myocardial Contraction; Norepinephrine; Rats; Rats, Inbred Strains; Synaptic Transmission; Yohimbine

1983
Changes in the binding to platelets of [3H]imipramine and [3H]yohimbine in normal subjects taking amitriptyline.
    Neuropharmacology, 1984, Volume: 23, Issue:2B

    Topics: Adult; Amitriptyline; Blood Platelets; Humans; Imipramine; Kinetics; Male; Time Factors; Yohimbine

1984
Biphasic effects of typical antidepressants and mianserin, an atypical antidepressant, on aggressive behavior in socially isolated mice.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:3

    Topics: Aggression; Amitriptyline; Animals; Antidepressive Agents; Brain Chemistry; Clomipramine; Male; Maprotiline; Mianserin; Mice; Mice, Inbred Strains; Motor Activity; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha; Selective Serotonin Reuptake Inhibitors; Social Isolation; Yohimbine

1993
Antinociception induced by amitriptyline and imipramine is mediated by alpha2A-adrenoceptors.
    Japanese journal of pharmacology, 2000, Volume: 82, Issue:2

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Tricyclic; Dose-Response Relationship, Drug; Imidazoles; Imipramine; Indoles; Isoindoles; Male; Mice; Naloxone; Organophosphorus Compounds; Receptors, Adrenergic, alpha-2; Yohimbine

2000
THE INCREASE IN THE TOXICITY OF YOHIMBINE INDUCED BY IMIPRAMINE AND OTHER DRUGS IN MICE.
    British journal of pharmacology and chemotherapy, 1963, Volume: 21

    Topics: Adrenal Glands; Adrenalectomy; Amitriptyline; Animals; Anti-Allergic Agents; Brain; Central Nervous System Stimulants; Chlorpromazine; Chlorprothixene; Epinephrine; Heart; Histamine H1 Antagonists; Hypnotics and Sedatives; Imipramine; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Norepinephrine; Pharmacology; Research; Reserpine; Serotonin; Sympatholytics; Toxicology; Tranquilizing Agents; Yohimbine

1963
A COMPARISON OF IMIPRAMINE, CHLORPROMAZINE AND RELATED DRUGS IN VARIOUS TESTS INVOLVING AUTONOMIC FUNCTIONS AND ANTAGONISM OF RESERPINE.
    British journal of pharmacology and chemotherapy, 1964, Volume: 23

    Topics: Alcoholic Intoxication; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Autonomic Nervous System; Bradycardia; Central Nervous System Stimulants; Chlorpromazine; Chlorprothixene; Desipramine; Dogs; Epinephrine; Imipramine; Mice; Norepinephrine; Pharmacology; Promazine; Rats; Research; Reserpine; Sleep; Toxicology; Tranquilizing Agents; Vasomotor System; Yohimbine

1964
The synergistic interaction between morphine and maprotiline after intrathecal injection in rats.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:4

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Citalopram; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Injections, Spinal; Male; Maprotiline; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Selective Serotonin Reuptake Inhibitors; Time Factors; Yohimbine

2009
Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via α1- and α2-Adrenergic Receptors.
    ACS chemical neuroscience, 2023, 04-05, Volume: 14, Issue:7

    Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Duloxetine Hydrochloride; Hyperalgesia; Neuralgia; Norepinephrine; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Spinal Cord Dorsal Horn; Yohimbine

2023