amitriptyline and trazodone

amitriptyline has been researched along with trazodone in 86 studies

Research

Studies (86)

Timeframe	Studies, this research(%)	All Research%
pre-1990	43 (50.00)	18.7374
1990's	15 (17.44)	18.2507
2000's	14 (16.28)	29.6817
2010's	13 (15.12)	24.3611
2020's	1 (1.16)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Hietala, J; Kuoppamäki, M; Laakso, A; Majasuo, H; Pälvimäki, EP; Roth, BL; Syvälahti, E	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Gozalbes, R; Pineda-Lucena, A	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brignone, A; Genco, S; Puca, FM; Serlenga, L; Specchio, LM	1
Bobkova, NV; Gurevich, EV; Katkov, YA; Nesterova, IV; Otmakhova, NA	2
Deanović, Z; Jakovljević, M; Mück-Seler, D	1
Curran, HV; Lader, M; Sakulsripong, M	1
Blanchi, M; De Conno, F; Panerai, AE; Ripamonti, C; Sacerdote, P; Ventafridda, V; Zecca, E	1
Brown, CS; Bryant, SG; Hokanson, JA	1
Hales, RE; Silver, JM; Yudofsky, SC	1
Breitner, JC; Figiel, GS; Krishnan, KR; Nemeroff, CB	1
Altamura, AC; Carpiniello, B; Carucci, G; Hadjchristos, C; Mauri, MC; Minervini, M; Montanini, R; Perini, M; Rudas, N; Scapicchio, PL	1
Ankier, SI; Botros, WA; McManus, IC; Priest, RG; Samir, ZY; Steinert, J	1
Klieser, E; Lehmann, E	2
Carney, PA; Healy, D; Leonard, BE; O'Halloran, A	1
Blacker, R; Chapman, N; Davey, A; Shanks, NJ	1
Altamura, AC; Carucci, G; Colacurcio, F; Hadjchristos, C; Mauri, MC; Minervini, M; Montanini, R; Perini, M; Rudas, N; Scapicchio, PL	1
Bonezzi, C; Caraceni, A; De Conno, F; Guarise, G; Ramella, G; Saita, L; Silvani, V; Tamburini, M; Toscani, F; Ventafridda, V	2
Atwood, C; Beck, NC; Brownlee-Duffeck, M; Elliott, TR; Frank, RG; Haut, AE; Kashani, JH; Kay, DR; Parker, JC; Smith, E	1
Banjar, W; Bradshaw, CM; Longmore, J; Szabadi, E	2
Burns, M; Jaffe, J; Moskowitz, H	1
Bird, M; Cole, JO; Friedman, L; Hecht Orzack, M; McEachern, J	1
Ankier, SI; Turner, P; Warrington, SJ	2
Burns, MM; Moskowitz, H	1
Baumann, U; Eckmann, F; Stieglitz, RD	1
Ankier, SI; Ather, SA; Middleton, RS	1
Clifford, DB; Hicks, FG; Rutherford, JL; Zorumski, CF	1
Kalin, NH; Wamboldt, MZ; Weiler, SJ	1
Carney, PA; Healy, D; Leonard, BE	2
Ankier, SI; Silverstone, T; Turner, P; van de Merwe, TJ; Warrington, SJ	1
Kane, JM; Lieberman, J	1
Gold, MS; Lydiard, RB; Pottash, AL	1
Ankier, SI; Kerr, TA; McClelland, HA; Stephens, DA	1
Ankier, SI; Silverstone, T; Van de Merwe, TJ	1
Wrigglesworth, SJ	1
Aprison, MH; Hendrie, HC; Hingtgen, JN	1
Kieback, DG	1
Colucci d'Amato, C; De Angelis, G; Giordano, L; Iaccarino, C; Marmo, E; Mastrosimone, F	1
Finnerty, RJ; Goldberg, HM	1
Ankier, SI; Murphy, JE	1
Beckmann, H; Kasper, S; Moises, HW	1
Case, WG; Rickels, K	1
Kieback, D	1
Chiu, EK; Richardson, JS	1
Bobon, DP; Lapierre, YD; Lottin, T	1
Finnerty, RJ; Goldberg, HL	1
Court, F; Fuke, C; Pounder, DJ; Sadler, DW	1
Abe, T; Ishiguro, T; Nisijima, K; Shimizu, M	1
Bobkova, NV; Gurevich, EV; Nesterov, VI; Nesterova, IV; Otmakhova, NA	1
Bakish, D; Cavazzoni, P; Chudzik, J; Hrdina, PD; Lapierre, YD; Ravindran, A	1
Wolfe, RM	1
Casis, O; Sánchez-Chapula, JA	1
Ellison, Z; Evans, CL; Fombonne, E; Ha, Y; Saisch, S	1
Garrido Barral, A; González Moneo, MJ	1
Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM	1
Bateman, DN; Chick, J; Good, AM; Kelly, CA; Masterton, G	1
Mohamed, GG; Mohamed, NA; Nour El-Dien, FA	1
Khalil, SM; Mohamed, GG; Mohamed, NA; Nour El-Dien, FA	1
Bertschy, G; Bondolfi, G; Golaz, J; Rachid, F	1
El-Dien, FA; Mohamed, GG; Mohamed, NA	1
Hasić, S; Jadrić, R; Kiseljaković, E; Winterhalter-Jadrić, M	1
Koval'chuk, VV	1
Wichniak, A; Wierzbicka, A	1
Clark, MS; Jamieson, B; Smith, PO	1
Baldo, P; Cecco, S; Doree, C; McFerran, D; Molin, P	1
Perza, MN; Rosini, JM; Schneider, LA	1
Alessi-Severini, S; Bolton, J; Chateau, D; Enns, MW; Leong, C; Prior, HJ; Sareen, J	1
Benz, P; Farkas, A; Ryan, K; Theobald, J; Zosel, A	1

Reviews

7 review(s) available for amitriptyline and trazodone

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Psychopharmacology of depression in neurologic disorders. The Journal of clinical psychiatry, 1990, Volume: 51 Suppl Topics: Amitriptyline; Antidepressive Agents; Depressive Disorder; Electroconvulsive Therapy; Humans; Nervous System Diseases; Neurocognitive Disorders; Trazodone	1990
The efficacy of amoxapine, maprotiline, and trazodone in comparison to imipramine and amitriptyline: a review of the literature. Psychopharmacology bulletin, 1984,Spring, Volume: 20, Issue:2 Topics: Amitriptyline; Amoxapine; Anthracenes; Clinical Trials as Topic; Depression; Dibenzoxazepines; Humans; Imipramine; Maprotiline; Piperazines; Time Factors; Trazodone	1984
Antidepressant withdrawal reactions. American family physician, 1997, Volume: 56, Issue:2 Topics: Adult; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Clomipramine; Cyclohexanols; Drug Administration Schedule; Female; Humans; Male; Monoamine Oxidase Inhibitors; Selective Serotonin Reuptake Inhibitors; Substance Withdrawal Syndrome; Trazodone; Venlafaxine Hydrochloride	1997
[Latest therapies for treating dementia]. Atencion primaria, 2002, May-15, Volume: 29, Issue:8 Topics: Adult; Aged; Alzheimer Disease; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Clinical Trials as Topic; Cognition; Cohort Studies; Controlled Clinical Trials as Topic; Dementia, Vascular; Donepezil; Female; Fluoxetine; Galantamine; Haloperidol; Hormone Replacement Therapy; Humans; Hydroxychloroquine; Indans; Middle Aged; Nootropic Agents; Piperidines; Placebos; Practice Guidelines as Topic; Quality of Life; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Time Factors; Trazodone	2002
[The effects of antidepressants on sleep in depressed patients with particular reference to trazodone in comparison to agomelatine, amitriptyline, doxepin, mianserine and mirtazapine]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2011, Volume: 31, Issue:181 Topics: Amitriptyline; Antidepressive Agents; Depression; Doxepin; Humans; Mianserin; Mirtazapine; Sleep; Sleep Initiation and Maintenance Disorders; Sleep, REM; Trazodone	2011
Antidepressants for patients with tinnitus. The Cochrane database of systematic reviews, 2012, Sep-12, Issue:9 Topics: Amitriptyline; Antidepressive Agents; Depression; Humans; Nortriptyline; Paroxetine; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Tinnitus; Trazodone; Trimipramine	2012

Trials

34 trial(s) available for amitriptyline and trazodone

Article	Year
Effect of antidepressant treatment on platelet 5-HT content and relation to therapeutic outcome in unipolar depressive patients. Journal of affective disorders, 1991, Volume: 23, Issue:3 Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Blood Platelets; Depressive Disorder; Double-Blind Method; Female; Fluvoxamine; Humans; Male; Maprotiline; Middle Aged; Oximes; Psychiatric Status Rating Scales; Serotonin; Trazodone	1991
Does tolerance develop to the sedative and amnesic effects of antidepressants? A comparison of amitriptyline, trazodone and placebo. European journal of clinical pharmacology, 1991, Volume: 40, Issue:1 Topics: Adult; Amitriptyline; Amnesia; Drug Tolerance; Female; Humans; Hypnotics and Sedatives; Male; Mental Recall; Placebos; Psychomotor Performance; Salivation; Trazodone	1991
Clinical activity and tolerability of trazodone, mianserin, and amitriptyline in elderly subjects with major depression: a controlled multicenter trial. Clinical neuropharmacology, 1989, Volume: 12 Suppl 1 Topics: Aged; Amitriptyline; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Mianserin; Middle Aged; Multicenter Studies as Topic; Random Allocation; Time Factors; Trazodone	1989
Clinical assessment and performance tasks in depression: a comparison of amitriptyline and trazodone. The British journal of psychiatry : the journal of mental science, 1989, Volume: 155 Topics: Adolescent; Adult; Aged; Amitriptyline; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Problem Solving; Psychiatric Status Rating Scales; Psychomotor Performance; Randomized Controlled Trials as Topic; Reaction Time; Trazodone	1989
Experimental examination of trazodone. Clinical neuropharmacology, 1989, Volume: 12 Suppl 1 Topics: Adult; Amitriptyline; Anxiety; Depression; Depressive Disorder; Double-Blind Method; Female; Haloperidol; Humans; Male; Random Allocation; Schizophrenia; Trazodone	1989
The drug treatment of depression in general practice: a comparison of nocte administration of trazodone with mianserin, dothiepin and amitriptyline. Psychopharmacology, 1988, Volume: 95 Suppl Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Clinical Trials as Topic; Depression; Dothiepin; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Female; Humans; Male; Mianserin; Middle Aged; Random Allocation; Sleep; Trazodone	1988
Experimental comparison between the effect of standardized trazodone-amitriptyline and placebo treatment in vitalized depressive patients. Psychopharmacology, 1988, Volume: 95 Suppl Topics: Adult; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Trazodone	1988
Trazodone in late life depressive states: a double-blind multicenter study versus amitriptyline and mianserin. Psychopharmacology, 1988, Volume: 95 Suppl Topics: Aged; Aged, 80 and over; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Drug Tolerance; Female; Humans; Male; Mianserin; Middle Aged; Trazodone	1988
Trazodone for deafferentation pain. Comparison with amitriptyline. Psychopharmacology, 1988, Volume: 95 Suppl Topics: Adult; Afferent Pathways; Aged; Amitriptyline; Clinical Trials as Topic; Double-Blind Method; Humans; Middle Aged; Neuralgia; Random Allocation; Trazodone	1988
Antidepressant analgesia in rheumatoid arthritis. The Journal of rheumatology, 1988, Volume: 15, Issue:11 Topics: Aged; Amitriptyline; Antidepressive Agents; Arthritis, Rheumatoid; Depression; Desipramine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pain; Random Allocation; Trazodone	1988
Antidepressants for cancer pain and other painful syndromes with deafferentation component: comparison of amitriptyline and trazodone. Italian journal of neurological sciences, 1987, Volume: 8, Issue:6 Topics: Adult; Aged; Amitriptyline; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Humans; Middle Aged; Neoplasms; Neuralgia; Paresthesia; Random Allocation; Trazodone	1987
Effects of a controlled-release formulation of trazodone on psychomotor and autonomic functions in healthy volunteers: comparison with trazodone (conventional formulation), amitriptyline and placebo. European journal of clinical pharmacology, 1988, Volume: 34, Issue:1 Topics: Administration, Oral; Adolescent; Adult; Affect; Amitriptyline; Analysis of Variance; Autonomic Nervous System; Delayed-Action Preparations; Double-Blind Method; Drug Evaluation; Humans; Male; Psychomotor Performance; Pupil; Salivation; Time Factors; Trazodone	1988
A comparison of the effects of trazodone and amitriptyline on skills performance by geriatric subjects. The Journal of clinical psychiatry, 1986, Volume: 47, Issue:5 Topics: Administration, Oral; Age Factors; Aged; Amitriptyline; Attention; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Pattern Recognition, Visual; Perceptual Masking; Placebos; Psychomotor Performance; Reaction Time; Sleep Stages; Trazodone	1986
Weight changes in antidepressants: a comparison of amitriptyline and trazodone. Neuropsychobiology, 1986, Volume: 15 Suppl 1 Topics: Adolescent; Adult; Amitriptyline; Body Weight; Depressive Disorder; Humans; Middle Aged; Trazodone	1986
Evaluation of possible interactions between ethanol and trazodone or amitriptyline. Neuropsychobiology, 1986, Volume: 15 Suppl 1 Topics: Adult; Amitriptyline; Cognition; Double-Blind Method; Drug Interactions; Ethanol; Female; Flicker Fusion; Humans; Kinetics; Male; Memory; Motor Skills; Reaction Time; Trazodone	1986
Cognitive performance in geriatric subjects after acute treatment with antidepressants. Neuropsychobiology, 1986, Volume: 15 Suppl 1 Topics: Aged; Amitriptyline; Arousal; Attention; Cognition; Female; Humans; Male; Memory, Short-Term; Middle Aged; Perceptual Masking; Pursuit, Smooth; Trazodone; Visual Perception	1986
Self-rating data as a selecting factor in clinical trials of psychotropic drugs. European archives of psychiatry and neurological sciences, 1985, Volume: 235, Issue:2 Topics: Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Psychological Tests; Trazodone	1985
A double-blind evaluation of trazodone in the treatment of depression in the elderly. The British journal of clinical practice, 1985, Volume: 39, Issue:5 Topics: Aged; Amitriptyline; Clinical Trials as Topic; Depression; Double-Blind Method; Female; Humans; Male; Middle Aged; Trazodone	1985
Biochemical correlates of antidepressant response. Results of a trazodone versus amitriptyline trial. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Amitriptyline; Blood Platelets; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans; Kinetics; Piperazines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin; Trazodone; Tryptophan	1984
A double-blind study to compare trazodone with amitriptyline in depressed patients. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Adult; Amitriptyline; Anxiety Disorders; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Piperazines; Trazodone	1984
A double-blind non-crossover placebo-controlled study between group comparison of trazodone and amitriptyline on cardiovascular function in major depressive disorder. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Adult; Amitriptyline; Arrhythmias, Cardiac; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Electrocardiography; Female; Heart Conduction System; Hemodynamics; Humans; Male; Piperazines; Trazodone	1984
The efficacy of amoxapine, maprotiline, and trazodone in comparison to imipramine and amitriptyline: a review of the literature. Psychopharmacology bulletin, 1984,Spring, Volume: 20, Issue:2 Topics: Amitriptyline; Amoxapine; Anthracenes; Clinical Trials as Topic; Depression; Dibenzoxazepines; Humans; Imipramine; Maprotiline; Piperazines; Time Factors; Trazodone	1984
Speed of onset of action of the newer antidepressants. Psychopharmacology bulletin, 1984,Spring, Volume: 20, Issue:2 Topics: Amitriptyline; Amoxapine; Antidepressive Agents; Clinical Trials as Topic; Depression; Depressive Disorder; Double-Blind Method; Humans; Imipramine; Maprotiline; Time Factors; Trazodone	1984
Trazodone. A comparative clinical and predictive study. Acta psychiatrica Scandinavica, 1984, Volume: 70, Issue:6 Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Female; Humans; Male; Middle Aged; Piperazines; Psychiatric Status Rating Scales; Trazodone; Xerostomia	1984
An evaluation of possible interactions between ethanol and trazodone or amitriptyline. British journal of clinical pharmacology, 1984, Volume: 18, Issue:4 Topics: Adult; Aggression; Amitriptyline; Drug Interactions; Ethanol; Female; Flicker Fusion; Humans; Kinetics; Male; Piperazines; Psychomotor Performance; Reaction Time; Trazodone	1984
Electrophysiological and haemodynamic changes with trazodone, amitriptyline and placebo in depressed out-patients. Current medical research and opinion, 1984, Volume: 9, Issue:5 Topics: Adult; Ambulatory Care; Amitriptyline; Blood Pressure; Depressive Disorder; Double-Blind Method; Electrocardiography; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Myocardial Contraction; Piperazines; Random Allocation; Trazodone	1984
[Psychological test methods in pharmacopsychiatry]. Pharmacopsychiatria, 1982, Volume: 15, Issue:5 Topics: Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans; Piperazines; Psychiatric Status Rating Scales; Trazodone	1982
A double-blind study of trazodone. Psychopharmacology bulletin, 1980, Volume: 16, Issue:3 Topics: Adjustment Disorders; Adolescent; Adult; Amitriptyline; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperazines; Placebos; Trazodone	1980
An evaluation of trazodone in the treatment of depression. Neuropharmacology, 1980, Volume: 19, Issue:12 Topics: Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Double-Blind Method; Doxepin; Humans; Middle Aged; Piperazines; Trazodone	1980
Trazodone and amitriptyline in treatment of depressed inpatients. A double-blind study. Pharmacopsychiatria, 1981, Volume: 14, Issue:5 Topics: Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Electroencephalography; Female; Humans; Male; Piperazines; Psychiatric Status Rating Scales; Trazodone	1981
Trazodone in depressed outpatients. The American journal of psychiatry, 1982, Volume: 139, Issue:6 Topics: Adult; Ambulatory Care; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Piperazines; Trazodone	1982
[Comparison of the Hamilton Depression Rating Scale and the Self Rating Scale BS (v. Zerssen) within a double blind study on the antidepressant effects of trazodone verus amitriptyline (author's transl)]. Pharmacopsychiatria, 1982, Volume: 15, Issue:3 Topics: Administration, Oral; Adult; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Piperazines; Psychiatric Status Rating Scales; Psychometrics; Trazodone	1982
Trazodone in the treatment of neurotic depression. The Journal of clinical psychiatry, 1980, Volume: 41, Issue:12 Pt 1 Topics: Adolescent; Adult; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Piperazines; Psychiatric Status Rating Scales; Trazodone	1980
[Pharmacologic correction of psycho-emotive disorders in the rehabilitation of patients after removal of brain tumors]. Voprosy onkologii, 2007, Volume: 53, Issue:6 Topics: Adult; Alprazolam; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Brain Neoplasms; Depression; Doxepin; Emotions; Female; Humans; Male; Maprotiline; Middle Aged; Moclobemide; Mood Disorders; Neurosurgical Procedures; Nialamide; Sertraline; Thiazepines; Trazodone; Treatment Outcome	2007

Other Studies

46 other study(ies) available for amitriptyline and trazodone

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor. Psychopharmacology, 1996, Volume: 126, Issue:3 Topics: Animals; Antidepressive Agents, Tricyclic; Choroid Plexus; Citalopram; Fluoxetine; Imipramine; Male; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors	1996
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
[Modifications induced by antidepressant drugs on the vestibulo-ocular reflex in man]. Bollettino della Societa italiana di biologia sperimentale, 1975, Oct-30, Volume: 51, Issue:20 Topics: Amitriptyline; Antidepressive Agents; Eye Movements; Humans; Imipramine; Nortriptyline; Phenelzine; Reflex; Reflex, Oculocardiac; Trazodone; Vestibule, Labyrinth	1975
Dissociation of multiple behavioral effects between olfactory bulbectomized C57Bl/6J and DBA/2J mice. Physiology & behavior, 1992, Volume: 52, Issue:3 Topics: Amitriptyline; Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Imipramine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Olfactory Bulb; Trazodone	1992
Studies on the effects of antidepressant drugs on the antinociceptive action of morphine and on plasma morphine in rat and man. Pain, 1990, Volume: 43, Issue:2 Topics: Amitriptyline; Analgesia; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Drug Synergism; Humans; Morphine; Nortriptyline; Rats; Rats, Inbred Strains; Trazodone	1990
A drug utilization review of prescribing patterns for trazodone versus amitriptyline. The Journal of clinical psychiatry, 1990, Volume: 51 Suppl Topics: Adult; Age Factors; Amitriptyline; Depressive Disorder; Drug Prescriptions; Drug Utilization; Female; Hospitalization; Humans; Male; Middle Aged; Recurrence; Retrospective Studies; Trazodone	1990
Radiologic correlates of antidepressant-induced delirium: the possible significance of basal-ganglia lesions. The Journal of neuropsychiatry and clinical neurosciences, 1989,Spring, Volume: 1, Issue:2 Topics: Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Basal Ganglia; Basal Ganglia Diseases; Delirium; Depressive Disorder; Female; Fluoxetine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nortriptyline; Risk Factors; Trazodone	1989
Peripheral adrenoceptors and serotonin receptors in depression. Changes associated with response to treatment with trazodone or amitriptyline. Journal of affective disorders, 1985, Volume: 9, Issue:3 Topics: Adolescent; Adult; Aged; Amitriptyline; Blood Platelets; Depressive Disorder; Double-Blind Method; Humans; Lymphocytes; Middle Aged; Platelet Aggregation; Receptors, Adrenergic; Receptors, Serotonin; Trazodone	1985
Antagonism of phenylephrine-evoked sweating by trazodone and amitriptyline in humans in vivo. British journal of clinical pharmacology, 1987, Volume: 23, Issue:2 Topics: Adolescent; Adult; Amitriptyline; Delayed-Action Preparations; Humans; Male; Phenylephrine; Sweating; Trazodone	1987
Acute effects of antidepressants on hippocampal seizures. Annals of neurology, 1985, Volume: 18, Issue:6 Topics: Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Bupropion; Desipramine; Epilepsy; Hippocampus; Imipramine; Maprotiline; Propiophenones; Rats; Trazodone	1985
Consistent reversal of abnormal DSTs after different antidepressant therapies in a patient with dementia. The American journal of psychiatry, 1985, Volume: 142, Issue:1 Topics: Amitriptyline; Antidepressive Agents; Dementia; Depressive Disorder; Dexamethasone; Humans; Hydrocortisone; Imipramine; Male; Middle Aged; Nortriptyline; Trazodone	1985
Heterogeneity of 5-hydroxytryptamine receptors in the rat uterus and stomach strip. British journal of pharmacology, 1983, Volume: 80, Issue:4 Topics: Amitriptyline; Animals; Female; In Vitro Techniques; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Organ Specificity; Rats; Receptors, Serotonin; Serotonin; Stomach; Trazodone; Uterine Contraction	1983
Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:3 Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Depression; Disease Models, Animal; Humans; Male; Methysergide; Mianserin; Piperazines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Synapses; Trazodone	1984
Personal experience with a combination of drugs in subjects with dopa resistant Parkinson's disease. Journal of medicine, 1980, Volume: 11, Issue:5-6 Topics: Amantadine; Amitriptyline; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Humans; Hyperkinesis; Levodopa; Lithium; Middle Aged; Parkinson Disease; Trazodone	1980
The acute effects of amitriptyline, iprindole and trazodone on blood pressure and heart rate in rats. Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:6 Topics: Amitriptyline; Animals; Blood Pressure; Heart Rate; Indoles; Injections, Intravenous; Injections, Intraventricular; Iprindole; Male; Piperazines; Rats; Rats, Inbred Strains; Trazodone	1982
Validity and sensitivity of the french version of the Zerssen BfS/BfS' self-rating mood scale during treatment with trazodone and amitriptyline. Progress in neuro-psychopharmacology, 1981, Volume: 5, Issue:5-6 Topics: Adolescent; Adult; Amitriptyline; Canada; Depression; Female; Humans; Male; Middle Aged; Piperazines; Psychiatric Status Rating Scales; Trazodone	1981
Drug accumulation and elimination in Calliphora vicina larvae. Forensic science international, 1995, Feb-28, Volume: 71, Issue:3 Topics: Amitriptyline; Animals; Diptera; Humans; Larva; Postmortem Changes; Temazepam; Trazodone; Trimipramine	1995
Antidepressants suppress bulbectomy-induced augmentation of voluntary alcohol consumption in C57B1/6j but not in DBA/2j mice. Physiology & behavior, 1994, Volume: 56, Issue:3 Topics: Alcohol Drinking; Amitriptyline; Animals; Antidepressive Agents; Arousal; Depressive Disorder; Disease Models, Animal; Imipramine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Olfactory Bulb; Smell; Species Specificity; Trazodone	1994
A case of serotonin syndrome induced by concomitant treatment with low-dose trazodone and amitriptyline and lithium. International clinical psychopharmacology, 1996, Volume: 11, Issue:4 Topics: Amitriptyline; Anxiety; Bipolar Disorder; Humans; Lithium; Male; Middle Aged; Trazodone	1996
Bulbectomy-induced loss of raphe neurons is counteracted by antidepressant treatment. Progress in neuro-psychopharmacology & biological psychiatry, 1997, Volume: 21, Issue:1 Topics: Amitriptyline; Animals; Antidepressive Agents; Male; Mice; Mice, Inbred C57BL; Olfactory Bulb; Raphe Nuclei; Trazodone	1997
Platelet serotonergic indices in major depression: up-regulation of 5-HT2A receptors unchanged by antidepressant treatment. Psychiatry research, 1997, Feb-07, Volume: 66, Issue:2-3 Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Blood Platelets; Carrier Proteins; Depressive Disorder; Doxepin; Female; Fluvoxamine; Follow-Up Studies; Humans; Male; Middle Aged; Personality Inventory; Receptor, Serotonin, 5-HT2A; Receptors, Drug; Receptors, Serotonin; Serotonin; Trazodone; Treatment Outcome	1997
Mechanism of block of cardiac transient outward K+ current (I(to)) by antidepressant drugs. Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:4 Topics: Action Potentials; Amitriptyline; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Binding Sites; Dose-Response Relationship, Drug; Drug Interactions; Heart Ventricles; Imipramine; Maprotiline; Mianserin; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Structure-Activity Relationship; Trazodone; Ventricular Function	1998
Tricyclic antidepressants in adolescent depression. A case report. European child & adolescent psychiatry, 1998, Volume: 7, Issue:3 Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Child; Depressive Disorder; Dothiepin; Drug Monitoring; Drug Therapy, Combination; Electrocardiography; Humans; Lithium Carbonate; Lofepramine; Male; Paroxetine; Trazodone	1998
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. Pharmacological research, 2003, Volume: 48, Issue:2 Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Fluoxetine; Imipramine; Inflammation; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Sertraline; Trazodone	2003
Are selective serotonin re-uptake inhibitors associated with an increased risk of self-harm by antidepressant overdose? European journal of clinical pharmacology, 2004, Volume: 60, Issue:3 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Doxepin; Drug Overdose; Drug Prescriptions; Emergency Service, Hospital; Female; Fluoxetine; Humans; Imipramine; Information Services; Male; Mianserin; Mirtazapine; Paroxetine; Patient Admission; Patient Readmission; Poison Control Centers; Retrospective Studies; Risk Assessment; Scotland; Selective Serotonin Reuptake Inhibitors; Self-Injurious Behavior; Sertraline; Trazodone; Venlafaxine Hydrochloride	2004
Spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides through ion-pair formation using methyl orange and bromocresol green reagents. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2006, Volume: 65, Issue:1 Topics: Amitriptyline; Azo Compounds; Bromcresol Green; Dibenzocycloheptenes; Hydrogen-Ion Concentration; Indicators and Reagents; Molecular Structure; Pharmaceutical Preparations; Solvents; Spectrophotometry; Temperature; Time Factors; Trazodone	2006
Spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides through ion-pair formation with molybdenum and thiocyanate. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2006, Volume: 65, Issue:5 Topics: Absorption; Amitriptyline; Antidepressive Agents, Tricyclic; Ascorbic Acid; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Hydrochloric Acid; Hydrogen-Ion Concentration; Models, Biological; Molybdenum; Solvents; Spectrophotometry; Temperature; Thiocyanates; Time Factors; Trazodone	2006
Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2006, Volume: 7, Issue:4 Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antimanic Agents; Depressive Disorder, Major; Female; Humans; Methadone; Mood Disorders; Narcotics; Opipramol; Paroxetine; Prazepam; Psychiatric Status Rating Scales; Serotonin Syndrome; Severity of Illness Index; Substance-Related Disorders; Transcranial Magnetic Stimulation; Trazodone; Valproic Acid	2006
Utility of 7,7,8,8-tetracyanoquinodimethane charge transfer reagent for the spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2007, Dec-31, Volume: 68, Issue:5 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Dibenzocycloheptenes; Nitriles; Pharmaceutical Preparations; Solvents; Spectrophotometry; Temperature; Time Factors; Trazodone	2007
Beta-endorphins as possible markers for therapeutic drug monitoring. Bosnian journal of basic medical sciences, 2007, Volume: 7, Issue:1 Topics: Amitriptyline; Animals; Antidepressive Agents; beta-Endorphin; Biomarkers; Brain; Drug Administration Schedule; Drug Monitoring; Rats; Rats, Wistar; Trazodone	2007
FPIN's clinical inquiries: Antidepressants for the treatment of insomnia in patients with depression. American family physician, 2011, Nov-01, Volume: 84, Issue:9 Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Dose-Response Relationship, Drug; Doxepin; Evidence-Based Medicine; Humans; Mianserin; Mirtazapine; Practice Guidelines as Topic; Sleep Initiation and Maintenance Disorders; Trazodone; Trimipramine	2011
Suspected tricyclic antidepressant overdose successfully treated with lipids. Journal of emergency nursing, 2013, Volume: 39, Issue:3 Topics: Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Doxepin; Drug Overdose; Fat Emulsions, Intravenous; Humans; Male; Middle Aged; Trazodone; Treatment Outcome	2013
New antidepressant use in older adults: a Canadian population-based study (1997-2013). Aging & mental health, 2017, Volume: 21, Issue:7 Topics: Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cross-Sectional Studies; Drug Prescriptions; Drug Utilization; Female; Humans; Male; Manitoba; Mianserin; Middle Aged; Mirtazapine; Retrospective Studies; Trazodone; Venlafaxine Hydrochloride	2017
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes". Cardiovascular toxicology, 2022, Volume: 22, Issue:9 Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long QT Syndrome; Methadone; Mirtazapine; Poison Control Centers; Retrospective Studies; Risk Factors; Tachycardia, Ventricular; Torsades de Pointes; Trazodone; Ventricular Fibrillation	2022