amitriptyline has been researched along with theophylline in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (37.14) | 18.7374 |
| 1990's | 2 (5.71) | 18.2507 |
| 2000's | 8 (22.86) | 29.6817 |
| 2010's | 12 (34.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Klaus, D; Klumpp, F; Lemke, R; Zehner, J | 1 |
| Chai, CY; Cheng, JT; Chung, PM; Lee, HK; Wayner, MJ | 1 |
| Coret, IA; Hughes, MJ | 1 |
| Burcet Darde, J | 1 |
| Bruch, RC; Farbman, AI; Wong, KL | 1 |
| Birgersson, C; Ericsson, O; Göransson, M; Henthorn, T; Sjöqvist, F; Spina, E; von Bahr, C | 1 |
| Brown, JD; Lovrien, FC; Steele, AA; Stone, DB | 1 |
| Kodama, T; Matsukado, Y; Shimizu, H; Suzuki, T; Tanaka, S | 1 |
| Born, GV | 1 |
| Berndt, S; Schwabe, U | 1 |
| Batzri, S | 1 |
| Bradley, MP; Forrester, IT | 1 |
| Mühlenbruch, B | 1 |
| Baker, CA; Flora, KP; Narasimhachari, N; Wood, JH | 1 |
| Bittinger, F; Herschel, S; Kirkpatrick, CJ; Wessler, I | 1 |
| Arici, A; Hocaoglu, N; Kalkan, S; Oransay, K; Tuncok, Y | 1 |
| Sanaei-Zadeh, H | 1 |
| Adeleke, OA; Choonara, YE; du Toit, LC; Kumar, P; Pillay, V; Tomar, LK; Tyagi, C | 1 |
| Chen, T; Han, L; Li, L; Lian, G; Yang, S | 1 |
2 review(s) available for amitriptyline and theophylline
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Determination of drugs in the saliva].
Topics: Acetazolamide; Amitriptyline; Anticonvulsants; Humans; Models, Biological; Nortriptyline; Pharmaceutical Preparations; Saliva; Theophylline | 1982 |
33 other study(ies) available for amitriptyline and theophylline
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
[Cyclic AMP and plasma renin activity in renal vein blood after amitryptiline, theophylline, furosemide and beta adrenergic blocking substances (author's transl)].
Topics: Adrenergic beta-Antagonists; Adult; Amitriptyline; Cyclic AMP; Furosemide; Humans; Middle Aged; Practolol; Propranolol; Renal Veins; Renin; Theophylline | 1976 |
Mechanisms of amitriptyline induced hypothermia in the rat.
Topics: Amitriptyline; Animals; Atropine; Body Temperature; Brain Chemistry; Bucladesine; Cyproheptadine; Depression, Chemical; Diphenhydramine; Fenclonine; Haloperidol; Male; Rats; Serotonin; Sympatholytics; Theophylline | 1977 |
A characteristic of the rate response which is common to several compounds that stimulate the heart.
Topics: Amitriptyline; Animals; Caffeine; Cyclic AMP; Dose-Response Relationship, Drug; Epinephrine; Female; Guinea Pigs; Heart Atria; Heart Rate; Heterocyclic Compounds; Histamine; Male; Neurotransmitter Agents; Norepinephrine; Rabbits; Stimulation, Chemical; Theophylline | 1975 |
[Accidental epileptic crises. Importance of drugs and the genetic factor in their presentation].
Topics: Adult; Amitriptyline; Epilepsy; Humans; Male; Middle Aged; Theophylline | 1992 |
Amitriptyline-mediated inhibition of neurite outgrowth from chick embryonic cerebral explants involves a reduction in adenylate cyclase activity.
Topics: Adenylyl Cyclases; Amitriptyline; Animals; Axons; Brain; Bucladesine; Chick Embryo; Colforsin; Cyclic AMP; Dibutyryl Cyclic GMP; Guanylyl Imidodiphosphate; Theophylline | 1991 |
Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes.
Topics: Amitriptyline; Antipyrine; Desipramine; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Metoprolol; Microsomes, Liver; Theophylline | 1985 |
Effect of amitriptyline on lipolysis and cyclic AMP concentration in isolated fat cells.
Topics: Adipose Tissue; Amitriptyline; Animals; Butyrates; Cells; Cyclic AMP; Drug Antagonism; Epididymis; Fatty Acids, Nonesterified; Glycerol; Lipid Mobilization; Male; Norepinephrine; Rats; Stimulation, Chemical; Theophylline | 1972 |
Stimulated formation of adenosine 3',5'-monophosphate by desipramine in brain slices.
Topics: Adenine; Adenosine Triphosphate; Amitriptyline; Animals; Brain; Carbon Isotopes; Chlorpromazine; Cyclic AMP; Desipramine; Guinea Pigs; Histamine; Imipramine; Male; Norepinephrine; Perphenazine; Phentolamine; Phosphoric Monoester Hydrolases; Propranolol; Rats; Rats, Inbred Strains; Theophylline; Tritium; Veratrine | 1971 |
Inhibition of platelet aggregation by chemicals and drugs.
Topics: Adenosine; Amitriptyline; Blood Coagulation; Blood Platelets; Chlorpromazine; Cyclic AMP; Fibrinogen; Imipramine; Prostaglandins; Theophylline | 1971 |
Effect of psychotropic drugs on phosphodiesterase and cyclic AMP level in rat brain in vivo.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Chlorpromazine; Chlorprothixene; Cyclic AMP; Desipramine; Haloperidol; Imipramine; Male; Phosphoric Diester Hydrolases; Rats; Theophylline; Tranquilizing Agents; Triflupromazine; Tritium | 1973 |
Action of tricyclic antidepressants on cyclic AMP in mucosal cells from guinea pig stomach.
Topics: Alprostadil; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brain; Cyclic AMP; Dimaprit; Gastric Mucosa; Guinea Pigs; Histamine; In Vitro Techniques; Oxygen Consumption; Prostaglandins E; Receptors, Histamine; Theophylline; Thiourea | 1984 |
Identification of calmodulin-like activity in human seminal plasma.
Topics: Amitriptyline; Biological Transport, Active; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Calmodulin; Cell Membrane; Chlorpropamide; Erythrocyte Membrane; Erythrocytes; Hot Temperature; Humans; Kinetics; Magnesium; Male; Semen; Theophylline; Trypsin | 1980 |
Dependence of salivary drug concentration on salivary flow rate.
Topics: Amitriptyline; Humans; Iodides; Iodine; Lithium; Male; Nortriptyline; Pharmaceutical Preparations; Salicylates; Saliva; Salivation; Theophylline | 1982 |
Release of non-neuronal acetylcholine from the isolated human placenta is affected by antidepressants.
Topics: Acetylcholine; Amitriptyline; Antidepressive Agents; Dose-Response Relationship, Drug; Doxepin; Female; Humans; Hypoglycemic Agents; In Vitro Techniques; Metformin; Minoxidil; Neurons; Placenta; Pregnancy; Theophylline; Time Factors; Vasodilator Agents | 2007 |
An alternative antidote therapy in amitriptyline-induced rat toxicity model: theophylline.
Topics: Amitriptyline; Animals; Antidotes; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Drug Administration Schedule; Electrocardiography; Glucose; Heart Rate; Infusions, Intravenous; Injections, Intravenous; Male; Oxygen; Poisoning; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Theophylline; Time Factors | 2011 |
Can theophylline be an alternative antidote for amitriptyline toxicity?
Topics: Amitriptyline; Animals; Antidotes; Male; Purinergic P1 Receptor Antagonists; Theophylline | 2013 |
Evaluation of the impacts of formulation variables and excipients on the drug release dynamics of a polyamide 6,10-based monolithic matrix using mathematical tools.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chemistry, Pharmaceutical; Electrolytes; Excipients; Hydrophobic and Hydrophilic Interactions; Kinetics; Models, Molecular; Models, Statistical; Nylons; Particle Size; Phosphodiesterase Inhibitors; Solubility; Theophylline | 2013 |
Investigation of pH effect on cationic solute binding to keratin and partition to hair.
Topics: Amitriptyline; Cations; Hair; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Keratins; Microscopy, Electron, Transmission; Nortriptyline; Protein Binding; Spectrometry, Fluorescence; Theophylline; Thermodynamics | 2018 |