amitriptyline and protriptyline

amitriptyline has been researched along with protriptyline in 40 studies

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199030 (75.00)18.7374
1990's3 (7.50)18.2507
2000's4 (10.00)29.6817
2010's2 (5.00)24.3611
2020's1 (2.50)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Dudley, MW; Kane, JM; Miller, FP; Sorensen, SM1
Andrews, PR; Craik, DJ; Martin, JL1
Topliss, JG; Yoshida, F1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Cardoso, FC; Duggan, PJ; Kuiper, MJ; Lewis, RJ; Schmit, M; Tuck, KL1
Hollister, LE1
Richelson, E1
Levine, RM; Maickel, RP; Spaulding, JH; Zabik, JE1
Hollander, CS; Tai, HH1
Roth, JA1
Hullin, RP1
Hartman, BK; Preskorn, SH1
Albert, JM; Caille, G; Cooper, SF; Dugal, R1
Stewart, MJ; Watson, ID2
Olech, A1
Detaevernier, MR; Dryon, L; Massart, DL1
Tyber, MA1
Elonen, E; Mattila, MJ1
Elonen, E; Linnoila, M; Lukkari, I; Mattila, MJ1
Graf, U; van Schaik, N1
Chang, RS; Kling, P; Lotti, VJ1
Carter, RB; Leander, JD1
Beierle, FA; Hubbard, RW1
Isenberg, K; Livingston, RL; Wetzel, RD; Zucker, DK1
Elonen, E; Eränkö, P; Mattila, MJ; Puisto, EL1
Amsterdam, J; Brunswick, D; Mendels, J1
Forker, AD; Marshall, JB1
Lyskowksi, J; Nasrallah, HA; Schroeder, D1
Friedel, RO1
Bannister, SJ; Dolan, JW; Snyder, LR; van der Wal, S1
Robins, E; Welner, A; Welner, Z1
Creasey, DE; Mirin, SM; Schatzberg, AF1
Mathie, A; Wooltorton, JR1
Huang, Y1
Azar, N; Korobkova, EA; Ng, W; Nizamova, M; Venkatratnam, A; Williams, AK1

Reviews

5 review(s) available for amitriptyline and protriptyline

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Tricyclic antidepressants (first of two parts).
    The New England journal of medicine, 1978, Nov-16, Volume: 299, Issue:20

    Topics: Aged; Amines; Amitriptyline; Antidepressive Agents, Tricyclic; Chemical Phenomena; Chemistry; Child; Depression; Desipramine; Doxepin; Humans; Imipramine; Kinetics; Neurotransmitter Agents; Nortriptyline; Protriptyline

1978
Blood levels of tricyclic antidepressant drugs: assay procedures, reproducibility and relationship to therapeutic outcome and side effects.
    Postgraduate medical journal, 1977, Volume: 53 Suppl 4

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Double-Blind Method; Drug Interactions; Female; Humans; Imipramine; Kinetics; Nortriptyline; Protein Binding; Protriptyline

1977
The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels.
    The American journal of psychiatry, 1980, Volume: 137, Issue:6

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Desipramine; Doxepin; Heart; Humans; Imipramine; Nortriptyline; Protriptyline

1980
Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose, and management of complications.
    American heart journal, 1982, Volume: 103, Issue:3

    Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular System; Child; Depression; Desipramine; Doxepin; Electrocardiography; Hemodynamics; Humans; Hypotension; Imipramine; Kinetics; Middle Aged; Myocardium; Norepinephrine; Parasympatholytics; Protriptyline

1982

Trials

3 trial(s) available for amitriptyline and protriptyline

ArticleYear
Blood levels of tricyclic antidepressant drugs: assay procedures, reproducibility and relationship to therapeutic outcome and side effects.
    Postgraduate medical journal, 1977, Volume: 53 Suppl 4

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Double-Blind Method; Drug Interactions; Female; Humans; Imipramine; Kinetics; Nortriptyline; Protein Binding; Protriptyline

1977
Apparent pharmacokinetic interaction of diazepam and amitriptyline in psychiatric patients: a pilot study.
    Current therapeutic research, clinical and experimental, 1975, Volume: 18, Issue:5

    Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Diazepam; Drug Interactions; Half-Life; Humans; Kinetics; Male; Middle Aged; Nortriptyline; Pilot Projects; Protriptyline; Psychotic Disorders

1975
Effect of tricyclic antidepressants on individual symptoms.
    The Journal of clinical psychiatry, 1980, Volume: 41, Issue:9

    Topics: Affective Disorders, Psychotic; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Humans; Imipramine; Protriptyline; Psychotropic Drugs; Trimipramine

1980

Other Studies

33 other study(ies) available for amitriptyline and protriptyline

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
2,4-Dihydro-3H-1,2,4-triazole-3-thiones as potential antidepressant agents.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:6

    Topics: Animals; Antidepressive Agents; Desipramine; gamma-Aminobutyric Acid; Male; Mice; Monoamine Oxidase Inhibitors; Norepinephrine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Triazoles

1988
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Inhibition of N-type calcium ion channels by tricyclic antidepressants - experimental and theoretical justification for their use for neuropathic pain.
    RSC medicinal chemistry, 2022, Feb-23, Volume: 13, Issue:2

    Topics:

2022
Tricyclic antidepressants and histamine H1 receptors.
    Mayo Clinic proceedings, 1979, Volume: 54, Issue:10

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Atropine; Benztropine; Cells, Cultured; Clozapine; Cyproheptadine; Desipramine; Doxepin; Haloperidol; Histamine H1 Antagonists; Hydroxyzine; Imipramine; Mice; Neoplasms, Experimental; Neuroblastoma; Nortriptyline; Protriptyline; Receptors, Histamine; Receptors, Histamine H1; Receptors, Muscarinic

1979
Interactions of tricyclic antidepressant drugs with deprivation-induced fluid consumption by rats.
    Neuropharmacology, 1977, Volume: 16, Issue:4

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Doxepin; Drinking Behavior; Fenclonine; Imipramine; Male; Methyltyrosines; Nortriptyline; Protriptyline; Rats; Water Deprivation

1977
Regulation of prostaglandin metabolism: activation of 15-hydroxyprostaglandin dehydrogenase by chlorpromazine and imipramine related drugs.
    Biochemical and biophysical research communications, 1976, Feb-09, Volume: 68, Issue:3

    Topics: Alcohol Oxidoreductases; Amitriptyline; Animals; Chlorpromazine; Desipramine; Dibenzocycloheptenes; Enzyme Activation; Hydroxyprostaglandin Dehydrogenases; Imipramine; Kidney; Kinetics; NAD; Protriptyline; Swine

1976
Inhibition of rabbit monoamine oxidase by doxepin and related drugs.
    Life sciences, 1975, Apr-15, Volume: 16, Issue:8

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Platelets; Chlorprothixene; Deamination; Depression, Chemical; Dibenzocycloheptenes; Doxepin; Humans; Hydrogen-Ion Concentration; Imipramine; Lung; Mitochondria; Monoamine Oxidase Inhibitors; Phenethylamines; Propylamines; Protriptyline; Rabbits; Serotonin

1975
The effect of tricyclic antidepressants on cerebral fluid dynamics.
    Biological psychiatry, 1979, Volume: 14, Issue:2

    Topics: Amitriptyline; Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Male; Nortriptyline; Protriptyline; Rats; Receptors, Adrenergic; Water

1979
Assay of tricyclic structured drugs and their metabolites in urine by high-performance liquid chromatography.
    Journal of chromatography, 1977, Apr-01, Volume: 134, Issue:1

    Topics: Amitriptyline; Chlorpromazine; Chromatography, High Pressure Liquid; Dibenzocycloheptenes; Humans; Imipramine; Nortriptyline; Protriptyline

1977
[Complex rhodanate salts as precipitating reagents in assaying organic bases. IV. Use of potassium hexarhodanodiammochromate (III) and ammonium tetrarhodanodiammochromate (III) for assaying amitriptyline and other dibenzocycloheptene derivatives].
    Acta poloniae pharmaceutica, 1976, Volume: 33, Issue:1

    Topics: Amitriptyline; Chemical Phenomena; Chemical Precipitation; Chemistry; Dibenzocycloheptenes; Indicators and Reagents; Nortriptyline; Potassium Dichromate; Protriptyline; Quaternary Ammonium Compounds; Thiocyanates

1976
The separation of some tricyclic antidepressants by high-performance liquid chromatography.
    Journal of chromatography, 1976, Nov-17, Volume: 128, Issue:1

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Clomipramine; Desipramine; Imipramine; Microchemistry; Nortriptyline; Protriptyline; Trimipramine

1976
The relationship between hiatus hernia and tricyclic antidepressants: a report of five cases.
    The American journal of psychiatry, 1975, Volume: 132, Issue:6

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Esophagogastric Junction; Female; Gastroesophageal Reflux; Hernia, Diaphragmatic; Hernia, Hiatal; Humans; Imipramine; Male; Middle Aged; Muscle Tonus; Muscle, Smooth; Parasympatholytics; Protriptyline

1975
Separation and quantitative determination of tricyclic antidepressants by high-performance liquid chromatography.
    Journal of chromatography, 1975, Jul-16, Volume: 110, Issue:2

    Topics: Amitriptyline; Chromatography; Dibenzocycloheptenes; Nortriptyline; Protriptyline; Solvents

1975
Cardiovascular effects of amitriptyline, nortriptyline, protriptyline, and doxepin in conscious rabbits after subacute pretreatment with protriptyline.
    Medical biology, 1975, Volume: 53, Issue:4

    Topics: Amitriptyline; Animals; Blood Pressure; Dibenzocycloheptenes; Doxepin; Electrocardiography; Heart Rate; Norepinephrine; Nortriptyline; Protriptyline; Rabbits; Tyramine

1975
Concentration of tricyclic antidepressants in plasma, heart and skeletal muscle after their intravenous infusion to anaesthetized rabbits.
    Acta pharmacologica et toxicologica, 1975, Volume: 37, Issue:4

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Doxepin; Infusions, Parenteral; Muscles; Myocardium; Nortriptyline; Protriptyline; Rabbits

1975
Genotoxicity evaluation of five tricyclic antidepressants in the wing somatic mutation and recombination test in Drosophila melanogaster.
    Mutation research, 1991, Volume: 260, Issue:1

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; DNA; Dose-Response Relationship, Drug; Drosophila melanogaster; Imipramine; Mutagenicity Tests; Nortriptyline; Protriptyline; Recombination, Genetic

1991
Pre- and postsynaptic adrenergic activation by norepinephrine reuptake inhibitors in the field-stimulated rat vas deferens.
    Life sciences, 1981, Aug-10, Volume: 29, Issue:6

    Topics: Amitriptyline; Animals; Chlorpromazine; Cocaine; Desipramine; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Male; Norepinephrine; Prazosin; Protriptyline; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Vas Deferens; Yohimbine

1981
Effects of norepinephrine and serotonin uptake inhibitors on the schedule-controlled behavior of the pigeon.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:3

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Columbidae; Conditioning, Operant; Desipramine; Doxepin; Fluoxetine; Iprindole; Male; Norepinephrine; Protriptyline; Reinforcement Schedule; Serotonin Antagonists

1984
Liquid chromatographic separation of antidepressant drugs: I. Tricyclics.
    Therapeutic drug monitoring, 1983, Volume: 5, Issue:3

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline; Promazine; Protriptyline

1983
Tricyclic antidepressants and delirium.
    The Journal of clinical psychiatry, 1983, Volume: 44, Issue:5

    Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Black People; Delirium; Desipramine; Female; Hospitalization; Humans; Male; Middle Aged; Protriptyline

1983
Prostaglandins and the cardiotoxic effects of doxepin in rabbits and guinea-pigs.
    Acta pharmacologica et toxicologica, 1980, Volume: 47, Issue:3

    Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Barium; Doxepin; Guinea Pigs; Ouabain; Prostaglandins F; Protriptyline; Rabbits

1980
TCA-induced mania: differences between switchers and nonswitchers.
    Biological psychiatry, 1982, Volume: 17, Issue:2

    Topics: Adult; Affective Disorders, Psychotic; Age Factors; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder; Desipramine; Doxepin; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Protriptyline

1982
The relationship of therapeutic response to antidepressant plasma levels: an update.
    The Journal of clinical psychiatry, 1982, Volume: 43, Issue:11 Pt 2

    Topics: Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents; Biological Availability; Depressive Disorder; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline; Patient Compliance; Protriptyline

1982
Liquid-chromatographic analysis for common tricyclic antidepressant drugs and their metabolites in serum or plasma with the technicon "FAST-LC" system.
    Clinical chemistry, 1981, Volume: 27, Issue:6

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Autoanalysis; Chromatography, High Pressure Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline; Protriptyline

1981
Hypomania and mania after withdrawal of tricyclic antidepressants.
    The American journal of psychiatry, 1981, Volume: 138, Issue:1

    Topics: Adult; Affective Disorders, Psychotic; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder; Female; Humans; Imipramine; Male; Protriptyline; Substance Withdrawal Syndrome

1981
Potent block of potassium currents in rat isolated sympathetic neurones by the uncharged form of amitriptyline and related tricyclic compounds.
    British journal of pharmacology, 1995, Volume: 116, Issue:4

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Potassium Channels; Protriptyline; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Stereoisomerism; Structure-Activity Relationship; Sympathetic Nervous System

1995
Inhibitory effect of noradrenaline uptake inhibitors on contractions of rat aortic smooth muscle.
    British journal of pharmacology, 1996, Volume: 117, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Aorta, Thoracic; Calcium; Endothelin-1; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrogen Mustard Compounds; Norepinephrine; Potassium; Protriptyline; Rats; Rats, Sprague-Dawley; Sympathomimetics; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents

1996
In vitro studies of DNA damage caused by tricyclic antidepressants: a role of peroxidase in the side effects of the drugs.
    Chemical research in toxicology, 2010, Sep-20, Volume: 23, Issue:9

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cattle; DNA; DNA Damage; Gas Chromatography-Mass Spectrometry; Horseradish Peroxidase; Hydrogen Peroxide; Hydrogen-Ion Concentration; Imipramine; Opipramol; Oxidation-Reduction; Protriptyline; Spectrophotometry, Ultraviolet

2010