amitriptyline has been researched along with nortriptyline in 691 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 473 (68.45) | 18.7374 |
| 1990's | 87 (12.59) | 18.2507 |
| 2000's | 60 (8.68) | 29.6817 |
| 2010's | 58 (8.39) | 24.3611 |
| 2020's | 13 (1.88) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Bunce, JD; Creese, MW; Grunewald, GL; Högberg, T; Ross, SB; Ström, P | 1 |
| Dudley, MW; Kane, JM; Miller, FP; Sorensen, SM | 1 |
| Chiang, GH; Unger, SH | 1 |
| Henderson, JD; Wilkerson, RD | 1 |
| Booth, RG; Brown, RL; Bucholtz, EC; Tropsha, A; Wyrick, SD | 1 |
| Medina-Hernández, MJ; Quiñones-Torrelo, C; Sagrado, S; Villanueva-Camañas, RM | 1 |
| Holsboer, F; Steckler, T; Uhr, M; Yassouridis, A | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Ikeda, K; Kobayashi, T; Washiyama, K | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| De Jonghe, S; Herdewijn, P; Moreels, L; Peigneur, S; Rozenski, J; Tian, J; Tytgat, J; Van den Steen, PE; Vandermosten, L | 1 |
| Cardoso, FC; Duggan, PJ; Kuiper, MJ; Lewis, RJ; Schmit, M; Tuck, KL | 1 |
| Brockmöller, J; Dücker, C; Gebauer, L; Jensen, O | 1 |
| Modestin, J; Petrin, A | 1 |
| Jøorgensen, A; Staehr, P | 1 |
| Hollister, LE | 3 |
| Richelson, E | 1 |
| Kamel, RS; Landon, J; Smith, DS | 1 |
| Allers, G; Bechtel, P; Vandel, B; Vandel, S; Volmat, R | 1 |
| Birkett, DJ; Graham, GG; Pond, SM; Wade, DN | 1 |
| Schiff, AA | 1 |
| Aherne, GW; Marks, V; Mould, G; Stout, G | 1 |
| Turner, P | 1 |
| Bailey, J; Christiansen, J; Coppen, A; Ghose, K; Jłrgensen, A; Kozulja, VG; Kungkunz, G; Matussek, N; Mikkleson, PL; Minsker, EJ; Montgomery, S; Rama Rao, VA; van de Poel, F; van Praag, HM | 1 |
| Goodwin, FK; Potter, WZ | 1 |
| Jungkunz, G; Kuss, HJ | 2 |
| Coppen, A; Rao, VA | 1 |
| Bartlett, D; Cooper, TB; Ives, JO; Lamborn, KR; Nies, A; Ravaris, CL; Robinson, DS | 1 |
| Levine, RM; Maickel, RP; Spaulding, JH; Zabik, JE | 1 |
| Coble, P; Hanin, I; Kupfer, DJ; Neil, J; Spiker, DG | 1 |
| Olson, DR; Shroff, JR; Weinryb, I | 1 |
| Bickel, MH | 1 |
| Braithwaite, R | 1 |
| Hullin, RP | 1 |
| Dorrity, F; Jobson, K; Linnoila, M | 1 |
| Amdisen, A; Jørgensen, A; Liisberg, P; Mose, H; Petersen, HE | 1 |
| Corona, GL; Fenoglio, L; Pinelli, P; Zerbi, F | 1 |
| Allers, G; Bechtel, P; Sandoz, M; Vandel, B; Vandel, S; Volmat, R | 1 |
| Cupano, J; Fann, WE; Garland, WA; Min, BH; Muccino, RR | 1 |
| Albert, JM; Cooper, SF; Dugal, R; Elie, R | 1 |
| Levine, RR | 1 |
| Coppen, A; Ghose, K | 1 |
| Braithwaite, R; Dawling, S; McAuley, R; Montgomery, DB; Montgomery, SA; Rani, SJ | 1 |
| Dujovne, CA; Ueda, I; Yasuhara, H | 1 |
| Bialos, DS; Docherty, JP; Giller, EL; Harkness, L; Jatlow, P | 1 |
| Oei, LS; Rodstein, M | 1 |
| Brunswick, DJ; Mendels, J; Needelman, B | 1 |
| Bloomingdale, LM; Bressler, B | 1 |
| Braithwaite, R; Dawling, S; McAuley, R; Montgomery, DR; Montgomery, SA; Rani, SJ | 1 |
| Hedley, LR; Wallach, MB | 1 |
| Hartman, BK; Preskorn, SH | 1 |
| Gupta, R; Molnar, G; Wallace, J | 1 |
| Chodera, A; Godlewski, J; Konkiewicz, B; Nowakowska, E | 1 |
| Erickson, SH; Heidrich, F; Smith, GH | 1 |
| Braithwaite, RA; Crome, P; Dawling, S | 1 |
| Bertilsson, L; Mellström, B; Sjöqvist, F | 1 |
| Goldstein, FJ; Malseed, RT | 1 |
| Burch, JE; Raddats, MA; Thompson, SG | 1 |
| Coble, PA; Kupfer, DJ; Rubinstein, D | 1 |
| Dhar, AK; Kutt, H | 1 |
| Aherne, GW; Marks, V; Mould, GP; Stout, G | 1 |
| Biggs, JT; Petit, JM; Spiker, DG; Ziegler, VE | 1 |
| Leppäluoto, J; Linnoila, M; Ranta, T; Seppälä, T | 1 |
| Biggs, JT; Ziegler, VE | 2 |
| Dorrity, F; Liljequist, R; Linnoila, M; Overo, KF; Seppälä, T | 1 |
| Albert, JM; Bertrand, M; Cooper, S; Dugal, R; Elie, R | 1 |
| Carr, AC; Hobson, RP | 1 |
| Moyes, IC; Moyes, RB | 2 |
| Cravey, RH; Garriott, JC; Lundberg, GD; Reynolds, PC; Shaw, RF | 1 |
| Adams, RF; Schmidt, GJ; Vandemark, FL | 1 |
| Aherne, GW; Riley, G; Risby, D; Robinson, JD | 1 |
| Haefelfinger, P | 1 |
| Braithwaite, RA; Montgomery, S; Robinson, JD | 1 |
| Bogaert, M; Desager, JP; Harvengt, C; Moerman, E; Vanderbist, M | 1 |
| Davis, CM; Fenimore, DC; Meyer, CJ | 1 |
| Braithwaite, R; Mellström, B | 1 |
| Bailey, DN; Jatlow, PI; Langou, RA; Van Dyke, C | 1 |
| Lohmann, HJ; Miles, DG; Proelss, HF | 1 |
| Ardekani, AB; Biggs, JT; Rosen, SH; Ziegler, VE | 1 |
| Chandler, JT; Diaz-Buxo, JA; Farmer, CD | 1 |
| Birkett, DJ; Garland, WA; Min, BH | 1 |
| Coble, P; Grau, T; Hanin, I; Kupfer, DJ; Neil, J; Nevar, C; Spiker, D | 1 |
| Bourgeois, ML; Tignol, J | 1 |
| Burch, J; Hullin, RP | 1 |
| Bennie, EH; Schiff, AA | 1 |
| Rosser, R | 1 |
| Schiff, AA; Sinclair, JM; Valle-Jones, JC; Walsh, MR | 1 |
| Albert, JM; Caille, G; Cooper, SF; Dugal, R | 1 |
| Baum, T; Butz, F; Much, DR; Peters, JR | 1 |
| Stewart, MJ; Watson, ID | 3 |
| Garland, WA | 1 |
| Hartvig, P; Näslund, B | 1 |
| Biggs, JT; Clayton, PJ; Ziegler, VE | 1 |
| Cooper, TB; Friedman, MJ; Green, R; Ives, JO; Nies, A; Ravaris, CL; Robinson, DS | 1 |
| Magnus, RV; Schiff, AA | 1 |
| Connor, JN; Johnson, GF; Solomon, HM | 1 |
| Hucker, HB; Stauffer, SC | 2 |
| Brodie, RR; Chasseaud, LF; Hawkins, DR | 1 |
| Maayani, S; Rehavi, M; Sokolovsky, M | 1 |
| Dixon, R; Lucek, R | 1 |
| Aaes-Jorgensen, T; Jorgensen, A | 1 |
| Biggs, JT; Knesevich, JW; Meyer, DA; Rosen, SH; Ziegler, VE | 1 |
| Davis, CM; Fenimore, DC; Hsu, F; Meyer, CJ; Zlatkis, A | 1 |
| Furlong, FW; Kapur, BM; Sellers, EM | 1 |
| Coble, P; Grau, T; Hanin, I; Kupfer, DJ; Spiker, DG | 1 |
| Olech, A | 1 |
| Baba, O; Fujiwara, J; Hanaoka, M; Ishino, H; Sasaki, K | 1 |
| Bonferoni, B; Corona, GL | 1 |
| Breyer, U; Villumsen, K | 1 |
| Burrows, GD; Davies, B; Hunt, D; Scoggins, BA; Sloman, JG; Vohra, J | 1 |
| Allen, D; Cooper, TB; Simpson, GM | 1 |
| Detaevernier, MR; Dryon, L; Massart, DL | 1 |
| Banazdkiewicz, W; Mrozikiewicz, A | 1 |
| Banaszkiewicz, W; Mrozikiewicz, A | 1 |
| Dostal, T; Kabes, J; Krsiak, M; Masek, K; Pöschlová, N; Volsan, O | 1 |
| Persson, G; Siwers, B | 1 |
| Burrows, GD; Sloman, G; Vohra, J | 1 |
| Brignone, A; Genco, S; Puca, FM; Serlenga, L; Specchio, LM | 1 |
| Elonen, E; Linnoila, M; Mäki, M; Mattila, MJ; Seppälä, T | 1 |
| Coppen, A; Lyle, WH; Montgomery, S | 1 |
| Henry, BW; Overall, JE; Woodward, JA | 1 |
| Blum, K; Hamilton, HE; Wallace, JE | 1 |
| Huang, CL; Liu, SJ; Waters, IW | 1 |
| Blum, K; Goggin, LK; Hamilton, HE; Wallace, JE | 1 |
| Belmonte, A; Tato, F | 1 |
| Bobkiewicz, T; Chodera, A; Nowakowska, E; Okulicz-Kozaryn, I | 1 |
| Jorgensen, A | 1 |
| Oksenkrug, GF | 1 |
| Elonen, E; Mattila, MJ | 1 |
| Maas, JW | 1 |
| Antonijevic, S; Gunne, LM; Jonsson, J | 1 |
| Banaszkiewicz, W; Grzymislawska, I; Mrozikiewica, A | 1 |
| Bobkiewicz, T; Chodera, A; Drutel, B; Szpunar, K | 1 |
| Elonen, E; Linnoila, M; Lukkari, I; Mattila, MJ | 1 |
| Bailey, DN; Jatlow, PI | 1 |
| Härtter, S; Hiemke, C | 1 |
| Baettig, D; Baumann, P; Breyer-Pfaff, U; Jonzier-Perey, M; Monney, C; Nill, K; Nusser, E; Pfandl, B | 1 |
| Dolezalová, M | 1 |
| Zhang, X | 1 |
| Fukuchi, H; Kimura, M; Kimura, Y; Kitaura, T; Miyake, K | 1 |
| Kuhs, H; Rolf, LH; Rudolf, GA; Schlake, HP | 1 |
| Barnes, JM; Barnes, NM; Champaneria, S; Costall, B; Hornsby, CD; Naylor, RJ | 1 |
| Heath, A; Hultén, BA; Knudsen, K; Mårtensson, E; Nyberg, G; Starmark, JE | 1 |
| Heath, A; Hultén, BA; Knudsen, K; Mårtensson, E; Nyberg, G; Svensson, C | 1 |
| Field, SL; Murray, M | 1 |
| Ho, IK; McCaslin, PP; Smith, TG; Yu, XZ | 1 |
| Chekalina, ND | 1 |
| Messiha, FS | 2 |
| Brockmöller, J; Müller, N; Roots, I | 1 |
| Aberg-Wistedt, A; Bertilsson, L; Dahl, ML; Nordin, C; Otani, K | 1 |
| Dilger, C; Fischer, W; Hutt, V; Jaeger, H; Mosberg, H; Pabst, G; Theodor, R | 1 |
| Graf, U; van Schaik, N | 1 |
| Bowden, CL; Casper, RC; Frazer, A; Katz, MM; Kocsis, J; Koslow, SH; Maas, JW; Secunda, S | 1 |
| Crompton, DR; Jellett, LB; Middleton, W; Pegg, SP | 1 |
| Shores, J; Spiehler, V; Wimbish, G | 1 |
| Bienenfeld, D; Burk, J; Geier, P; Kay, J; Marvel, NT; Nadolny, G; Slomowitz, M; Zimmer, L | 1 |
| Blanchi, M; De Conno, F; Panerai, AE; Ripamonti, C; Sacerdote, P; Ventafridda, V; Zecca, E | 1 |
| Brandys, J; Negrusz, A; Piekoszewski, W | 1 |
| Mizukami, Y; Yasuda, K | 1 |
| Allers, G; Bertschy, G; Vandel, B; Vandel, S; Volmat, R | 2 |
| Fukuchi, H; Kimura, M; Kimura, Y; Kitaura, T; Miyake, K; Nakahara, T; Sarai, K | 1 |
| Corona, GL; Cucchi, ML; Frattini, P; Santagostino, G; Savoldi, F; Schinelli, S; Zerbi, F | 1 |
| Appel, S; Brandis, S; Ori, J; Schild, K; Sirota, P; Zahavi, I | 1 |
| Fukuchi, H; Kimura, M; Kitaura, T; Miyake, K; Nakahara, T; Sarai, K | 1 |
| Chappey, O; Denis, H; Sabouraud, A; Scherrmann, JM; Urtizberea, M | 1 |
| Chaumont, A; Kintz, P; Lugnier, A; Mangin, P; Ritter-Lohner, S; Tracqui, A | 1 |
| Breitner, JC; Figiel, GS; Krishnan, KR; Nemeroff, CB | 1 |
| Batzri, S | 1 |
| Bryan, W; Fraser, AD; Isner, AF | 1 |
| Baumann, P; Eap, CB | 1 |
| Richens, A; Tedstone, JE; Tsanaclis, LM; Williams, J; Wilson, JF | 1 |
| Breyer-Pfaff, U; Gaertner, HJ; Giedke, H; Nill, K | 1 |
| Acosta, D; Davila, JC; Lenherr, A | 1 |
| Benetková, M; Kunová, A; Zácková, P | 1 |
| Arita, M; Izumi, F; Takara, H; Wada, A | 1 |
| Iri, H; Kanba, S; Kubo, H; Matsumoto, K; Yagi, G; Yuki, H | 1 |
| Coble, PA; Kupfer, DJ; Perel, JM; Pollock, B; Shipley, JA; Spiker, DG | 1 |
| Brini, A; Mantegazza, P; Panerai, AE; Sacerdote, P | 1 |
| Fernstrom, MH; Kupfer, DJ | 1 |
| Halliday, CA; Wise, H | 1 |
| Kärkkäinen, S; Neuvonen, PJ | 1 |
| Dorey, RC; Preskorn, SH; Widener, PK | 1 |
| Fairchild, CJ; Orsulak, PJ; Rush, AJ; Vasavada, N; Weissenburger, J | 1 |
| Allers, G; Bertschy, G; Jounet, JM; Vandel, S | 1 |
| Bowden, CL; Brunswick, D; Carl, J; Frazer, A; Hanin, I; Kocsis, JH; Koslow, SH; Robins, E | 1 |
| Mårtensson, E; Nyberg, G; Svensson, C | 1 |
| Liu, P | 1 |
| Domínguez-Gil, A; Fernández de Gatta, MM; García, MJ; Gutierrez, JR; Tamayo, M | 1 |
| Callaham, M; Pentel, P; Schumaker, H | 1 |
| Arvidsson, T | 1 |
| Belin, J; Bonnevialle, P; Cotonat, J; Guiraud-Chaumeil, B; Montastruc, JL; Rascol, O; Tran, MA | 1 |
| de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG | 1 |
| Collins, C; Hu, M; Izutsu, A; Jaklitsch, A; Pankey, S; Pirio, M; Singh, P | 1 |
| Dealy, RS; Hanin, I; Kupfer, DJ; Spiker, DG; Weiss, JC | 1 |
| Bertilsson, L; Sjöqvist, F | 2 |
| Bredehoeft, SJ; Chaturvedi, AK; Hidding, JT; Rao, NG; Smith, JC | 1 |
| Baumann, P; Jonzier-Perey, M; Koeb, L; Küpfer, A; Schöpf, J; Tinguely, D | 1 |
| Baumann, P; Jonzier-Perey, M; Koeb, L; Lê, PK; Schöpf, J; Tinguely, D | 1 |
| Baumann, P | 1 |
| Bertilsson, L; Nordin, C; Otani, K | 1 |
| Chaleby, K; el-Yazigi, A | 1 |
| Comincioli, V; Corona, GL; Cucchi, ML; Fenoglio, L; Frattini, P; Santagostino, G; Savoldi, F; Schinelli, S; Zerbi, F | 1 |
| Curry, SH; DeVane, CL; Wolfe, MM | 2 |
| Huang, Y; Liang, MZ; Qin, YP; Zeng, JZ | 1 |
| Goode, AG; Henry, JA; Minton, NA | 1 |
| Giedke, H; Heimann, H; Rein, W | 1 |
| Adan, F; Allen, D; Coccaro, EF; Cooper, TB | 1 |
| Dawling, S; Roy, D | 1 |
| Borbe, HO; Terlinden, R | 1 |
| Drímalová, M; Frank, V; Garaj, V; Móric, R; Pullmann, R | 1 |
| Dealy, RS; Griffin, SJ; Hanin, I; Perel, JM; Soloff, PH; Spiker, DG; Weiss, JC | 1 |
| Bialos, D; Giller, E; Harkness, L; Jatlow, P; Waldo, M | 1 |
| Lydiard, RB | 1 |
| Bertilsson, L; Mellström, B; Säwe, J; Sjöqvist, F | 1 |
| Kalin, NH; Wamboldt, MZ; Weiler, SJ | 1 |
| Ansseau, M; Coble, PA; Kupfer, DJ; Reynolds, CF | 1 |
| Borenstein, M; Brenner, R; Cooper, TB; Kane, JM; Lieberman, JA; Steinberg, H; Suckow, RF | 1 |
| Ansseau, M; Kupfer, DJ; Reynolds, CF | 1 |
| Baumann, P; Conti, M; Jonzier-Perey, M; Schöpf, J; Tinguely, D | 1 |
| Albright, D; Cooper, TB; Corcella, J; Howard, D; Robinson, DS | 1 |
| Hrdina, PD; Koranyi, EK; Lapierre, YD | 1 |
| Mac, DS; Preskorn, SH | 1 |
| Johannes, KJ; Jungkunz, G; Kuss, HJ | 1 |
| Ericsson, O; Nordin, C; Spina, E | 1 |
| Fernández de Gatta, M; García, MJ; Gutiérrez, JR; Verdejo Martín, A | 1 |
| Baumann, P; Jonzier-Perey, M; Koeb, L; Schnyder, C; Wertheimer, J | 1 |
| Baumann, P; Jonzier, M; Koeb, L; Schöpf, J; Tinguely, D | 1 |
| Aberg-Wistedt, A; Bertilsson, L; Gustafsson, LL; Nordin, C | 1 |
| Frisk-Holmberg, M; van der Kleijn, E | 1 |
| Gruvstad, M | 1 |
| Taub, A | 1 |
| al-Sarraj, S; Beckett, AH | 1 |
| Freeman, JW; Loughhead, MG | 1 |
| De Leenheer, A; Heyndrickx, A | 1 |
| Tuomisto, J | 1 |
| Coffer, AI; McDowall, RD; Robinson, AE | 1 |
| Coull, DC; Johnston, AW; Skinner, C | 1 |
| Lewis, SA; Oswald, I | 2 |
| Zingales, I | 1 |
| Gaut, ZN | 2 |
| Cater, BR; Chapman, D; Hawes, SM; Saville, J | 1 |
| Mlejnková, M; Spánková, H; Svehla, C | 1 |
| Brittain, RT | 1 |
| Garattini, S; Jori, A; Paglialunga, S | 1 |
| Otten, U; Zetler, G | 1 |
| Nybäck, H; Schubert, J; Sedvall, G | 1 |
| Sturman, G | 1 |
| Schrold, J | 1 |
| Lapin, IP; Oxenkrug, GF | 1 |
| Bevegård, S; Thorstrand, C | 1 |
| Fraser, MS; Parkin, JM | 1 |
| Karobath, M | 1 |
| Gronowitz, S; Ross, SB; Stjernström, NE; Yom-Tov, B | 1 |
| Bareggi, SR; Bonaccorsi, A; Franco, R; Garattini, S; Morselli, PL; Mundo, AS; Riva, E | 1 |
| Kümpel, Q; Mlcáková, K; Thomasová, E | 1 |
| Braithwaite, RA; Gaind, R; Nakra, BR | 1 |
| Elonen, E; Mattila, MJ; Saarnivaara, L | 1 |
| Imai, S; Ogura, C; Okuma, T; Uchida, Y; Yogi, H | 1 |
| Faber, DB; Man in 't Veld, WA; Mulder, C | 1 |
| Norheim, G | 2 |
| Elonen, E | 1 |
| Horn, AS; Trace, RC | 1 |
| Dostál, T; Kabes, J; Taussigová, D; Vinar, O | 1 |
| Lapin, IP; Oksenkrug, GF | 1 |
| Gripenberg, J | 1 |
| Anderson, J; Lambert, NG; Pigott, PV | 1 |
| Forsythe, WI; Merrett, JD; Redmond, A | 1 |
| Albert, JM; Caille, G; Mockle, JA; Panisset, JC; Sauriol, C | 1 |
| Protiva, M | 1 |
| Blazícek, P; Langos, J; Pekár, S; Vencel, P; Vrazda, L | 1 |
| Pigott, PV | 1 |
| Thorstrand, C | 1 |
| Bonaccorsi, A; Garattini, S; Jori, A; Samanin, R | 1 |
| Facino, RM; Pirillo, D; Santagostino, G | 1 |
| Berner, P; Kryspin-Exner, K; Poeldinger, W | 1 |
| Fung, HL; Ow, YH | 1 |
| O'Malley, K; Sawyer, PR; Stevenson, IH | 1 |
| König, J; Mlejnková, M; Rysánek, K; Spánková, H; Synek, P | 1 |
| Braithwaite, RA; Silverman, G | 1 |
| Gaffney, T; Gard, H; Hanenson, I; Knapp, D; Walle, T | 2 |
| Connor, JD; Crawford, IL; Pardridge, WM | 1 |
| Barker, GA; Brown, TC; Dunlop, ME; Loughnan, PM | 1 |
| Glogner, P; Heni, N; Herkel, L; Höfer, G | 1 |
| Boulu, R; Dupeyron, JP; Rossignol, P | 1 |
| Browning, M; O'Malley, K; Stevenson, I; Turnbull, MJ | 1 |
| Hansen, V; Jorgensen, A; Overo, KF | 1 |
| Mattila, MJ; Saarnivaara, L | 1 |
| Pare, CM; Trenchard, A; Turner, P | 1 |
| Furlong, FW; Luby, ED | 1 |
| Leahy, MR; Martin, IC | 2 |
| Mendels, J | 1 |
| Commarato, MA; McNeill, JH | 1 |
| Deza, PC; Marjerrison, G; Silzer, JC | 1 |
| Kanzler, M; Malitz, S | 1 |
| Borg, KO; Lagerström, PO; Westerlund, D | 1 |
| Montanini, R | 1 |
| Maickel, RP; Sokol, GH | 1 |
| Attree, T; Sawyer, P; Turnbull, MJ | 1 |
| Korman, MG; Mushin, G; Sedal, L; Williams, PO | 1 |
| von Bahr, C | 1 |
| Corona, GL; Facino, RM; Santagostino, G | 1 |
| Blomquist, M; Bonnichsen, R; Fri, CG; Mårde, Y; Ryhage, R | 1 |
| Braithwaite, RA; Widdop, B | 1 |
| Oates, JA; Shand, DG | 1 |
| Appel, P; Eckel, K; Harrer, G | 1 |
| Lipscomb, W; Ott, JE; Slovis, TL; Teitebaum, DT | 1 |
| Luke, CM | 1 |
| Ahonen, A; Pentilä, A | 1 |
| Bodi, T; Dykyj, R; Mapp, Y; Nodine, JH; Siegler, PE | 1 |
| Haider, I | 1 |
| Azarnoff, DL; Borgå, O; Forshell, GP; Sjöqvist, F | 1 |
| Rohte, O | 2 |
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| Gneushev, ET; Kondratenko, SN; Kukes, VG; Savelyeva, MI; Shikh, EV | 1 |
| Boone, NW; Jansen, RTP; Kuypers, AWHM; Neef, C; Robijns, K; Touw, DJ | 1 |
| Alsaab, S; Cobb, C; Haidari, M; Mansani, S; Ponds, D; Romero, L | 1 |
| Deckert, J; Hommers, L; Menke, A; Scherf-Clavel, M; Unterecker, S; Zebner, J | 1 |
| Aree, T | 1 |
| Conroy, MJ; Dunne, MR; Lysaght, J; McCrory, C; Royds, J | 1 |
| Augusti, R; Nascentes, CC; Oliveira, FM; Scheel, GL; Tarley, CRT | 1 |
| Haastrup, MB; Holgersen, NK; Lundstrøm, NH | 1 |
| Chaum, E; Guzinski, M; Lindner, E; Pendley, B | 1 |
| Casha, M; Grech, A; LaFerla, G; Mifsud Buhagiar, L; Serracino Inglott, A | 1 |
| Giles, R; Girard, MFC; Hopfgartner, G; Knight, P | 1 |
| Ahomäki, I; Böckerman, P; Pehkonen, J; Saastamoinen, L | 1 |
| Yamini, Y; Zamani, R | 1 |
| Moosavi, NS; Yamini, Y | 1 |
33 review(s) available for amitriptyline and nortriptyline
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Correlation between plasma concentration and clinical effect of neuroleptics and antidepressants].
Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dibenzazepines; Dose-Response Relationship, Drug; Fluphenazine; Humans; Imipramine; Nortriptyline; Perazine; Phenelzine; Thioridazine | 1976 |
Tricyclic antidepressants (first of two parts).
Topics: Aged; Amines; Amitriptyline; Antidepressive Agents, Tricyclic; Chemical Phenomena; Chemistry; Child; Depression; Desipramine; Doxepin; Humans; Imipramine; Kinetics; Neurotransmitter Agents; Nortriptyline; Protriptyline | 1978 |
Metabolic and analytic considerations in the design of immunoassays.
Topics: Amitriptyline; Animals; Anti-Arrhythmia Agents; Cyclic AMP; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Immunoassay; Nortriptyline; Pharmaceutical Preparations; Piperazines; Pregnenolone; Testosterone | 1979 |
Poisoning by tricyclic antidepressant drugs: general and pharmacokinetic considerations.
Topics: Accidents, Home; Adolescent; Adult; Aged; Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain Chemistry; Child; Child, Preschool; Desipramine; Dibenzazepines; Drug Interactions; Female; Humans; Imipramine; Infant; Intestinal Absorption; Kinetics; Liver; Lung; Male; Mice; Middle Aged; Nortriptyline; Opipramol; Poisoning; Protein Binding; Rats; Suicide | 1975 |
Blood levels of tricyclic antidepressant drugs: assay procedures, reproducibility and relationship to therapeutic outcome and side effects.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Double-Blind Method; Drug Interactions; Female; Humans; Imipramine; Kinetics; Nortriptyline; Protein Binding; Protriptyline | 1977 |
The role of plasma concentrations in the use of tricyclic antidepressant drugs.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Nortriptyline | 1979 |
[Blood levels of tricyclic antidepressants and their clinical effectiveness (review of the literature)].
Topics: Amitriptyline; Cardiovascular Diseases; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Nortriptyline; Psychophysiologic Disorders | 1991 |
Contribution of the variants of alpha 1-acid glycoprotein to its binding of drugs.
Topics: Amitriptyline; Depression; Dialysis; Genetic Variation; Humans; Nortriptyline; Orosomucoid; Pharmaceutical Preparations; Polymorphism, Genetic; Polysaccharides; Psychotropic Drugs | 1989 |
Slow hydroxylation of tricyclic antidepressants--relationship to polymorphic drug oxidation.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Debrisoquin; Desipramine; Female; Humans; Hydroxylation; Kinetics; Male; Middle Aged; Nortriptyline; Phenotype; Polymorphism, Genetic; Smoking; Twins, Dizygotic; Twins, Monozygotic | 1986 |
Tricyclic-resistant depression: treatment resistance or inadequate treatment?
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Humans; Imipramine; Intestinal Absorption; Kinetics; Nortriptyline; Patient Compliance | 1985 |
[Metabolism of tricyclic antidepressive agents].
Topics: Amitriptyline; Animals; Antidepressive Agents; Biotransformation; Dibenzazepines; Dibenzocycloheptenes; Dibenzoxepins; Guinea Pigs; Heterocyclic Compounds; Mice; Nortriptyline; Opipramol; Phenothiazines; Rats; Structure-Activity Relationship | 1972 |
Psychopharmacological news in the year 1971 from the viewpoint of a medicinal chemist.
Topics: Amitriptyline; Amphetamine; Antidepressive Agents; Antiparkinson Agents; Biotransformation; Cannabis; Chemistry, Pharmaceutical; Fenfluramine; Hallucinogens; Humans; Lysergic Acid Diethylamide; Nortriptyline; Psychopharmacology; Research; Structure-Activity Relationship; Tranquilizing Agents | 1973 |
[Monoamines and the pharmacological effects of tricyclic antidepressive agents].
Topics: Amitriptyline; Antidepressive Agents; Brain; Brain Chemistry; Central Nervous System; Chemical Phenomena; Chemistry; Desipramine; Humans; Hydroxyindoleacetic Acid; Imipramine; Methyltransferases; Monoamine Oxidase; Norepinephrine; Nortriptyline; Receptors, Drug; Serotonin | 1972 |
Antidepressant and antipsychotic plasma levels.
Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Chromatography; Dose-Response Relationship, Drug; Humans; Imipramine; Monitoring, Physiologic; Nortriptyline | 1984 |
Clinical pharmacology of antidepressant drugs: pharmacogenetics.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Depressive Disorder; Female; Genetic Variation; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Methylation; Middle Aged; Nortriptyline; Pharmacogenetics; Pregnancy; Twins, Dizygotic; Twins, Monozygotic | 1984 |
Plasma level monitoring of antidepressants: theoretical basis and clinical application.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Genetic Variation; Humans; Imipramine; Kinetics; Nortriptyline; Oxidation-Reduction; Patient Compliance; Pharmacogenetics | 1984 |
Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics.
Topics: Adipose Tissue; Adult; Aged; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety Disorders; Benzodiazepines; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Gastric Mucosa; Glomerular Filtration Rate; Humans; Imipramine; Kinetics; Middle Aged; Nordazepam; Nortriptyline | 1984 |
The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Desipramine; Doxepin; Heart; Humans; Imipramine; Nortriptyline; Protriptyline | 1980 |
Pharmacokinetics and clinical response to tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Humans; Imipramine; Kinetics; Nortriptyline | 1980 |
Measurement of serum drug levels in the assessment of antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Depression; Humans; Imipramine; Nortriptyline | 1980 |
[Determination of drugs in the saliva].
Topics: Acetazolamide; Amitriptyline; Anticonvulsants; Humans; Models, Biological; Nortriptyline; Pharmaceutical Preparations; Saliva; Theophylline | 1982 |
Tricyclic medication in children and the QT interval: case report and discussion.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Child; Contraindications; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Electrocardiography, Ambulatory; Exercise Test; Female; Humans; Imipramine; Long QT Syndrome; Nortriptyline; Practice Guidelines as Topic | 1995 |
Tricyclic antidepressant concentrations in plasma: an estimate of their sensitivity and specificity as a predictor of response.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline; ROC Curve; Sensitivity and Specificity | 1994 |
THE ANTIDEPRESSANT DRUGS.
Topics: Amitriptyline; Antidepressive Agents; Central Nervous System Stimulants; Depression; Depressive Disorder; Desipramine; Drug Therapy; Epidemiology; Humans; Imipramine; Mental Disorders; Monoamine Oxidase Inhibitors; Nortriptyline; Phenelzine; Psychopharmacology | 1965 |
The metabolic fate of amitriptyline, nortriptyline and amitriptylinoxide in man.
Topics: Amitriptyline; Humans; Nortriptyline | 2004 |
Antidepressants for patients with tinnitus.
Topics: Amitriptyline; Antidepressive Agents; Depression; Humans; Nortriptyline; Paroxetine; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Tinnitus; Trazodone; Trimipramine | 2012 |
Nortriptyline for neuropathic pain in adults.
Topics: Amines; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Clomipramine; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Middle Aged; Morphine; Neuralgia; Nortriptyline; Pregabalin; Randomized Controlled Trials as Topic | 2015 |
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Confounding Factors, Epidemiologic; Depressive Disorder, Major; Desipramine; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Evidence-Based Medicine; Fluoxetine; Humans; Imipramine; Mianserin; Mirtazapine; Nortriptyline; Paroxetine; Piperazines; Randomized Controlled Trials as Topic; Research Design; Sertraline; Treatment Outcome; Triazoles; Venlafaxine Hydrochloride | 2016 |
Antidepressant pharmacogenetics in children and young adults: A systematic review.
Topics: Adolescent; Amitriptyline; Antidepressive Agents; Child; Citalopram; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Female; Fluoxetine; Fluvoxamine; Humans; Male; Mental Disorders; Nortriptyline; Paroxetine; Pharmacogenetics; Serotonin Plasma Membrane Transport Proteins; Sertraline; Tryptophan Hydroxylase; Venlafaxine Hydrochloride; Young Adult | 2019 |
The effect of smoking on the plasma concentration of tricyclic antidepressants: a systematic review.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Imipramine; Nortriptyline; Smoking | 2022 |
80 trial(s) available for amitriptyline and nortriptyline
| Article | Year |
|---|---|
Amitriptyline plasma-concentration and clinical effect. A World Health Organisation Collaborative Study.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Denmark; Depression; Drug Evaluation; England; Female; Follow-Up Studies; Germany, West; Humans; International Cooperation; Male; Middle Aged; Netherlands; Nortriptyline; Time Factors; USSR; World Health Organization | 1978 |
Antidepressant drug levels and clinical response.
Topics: Adult; Amitriptyline; Antidepressive Agents; Biological Availability; Clinical Trials as Topic; Depression; Drug Evaluation; Humans; Middle Aged; Nortriptyline | 1978 |
Plasma tricyclic drug levels in amitriptyline-treated depressed patients.
Topics: Adult; Aged; Amitriptyline; Depression; Double-Blind Method; Erythrocytes; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Nortriptyline; Phenelzine; Time Factors | 1979 |
Blood levels of tricyclic antidepressant drugs: assay procedures, reproducibility and relationship to therapeutic outcome and side effects.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Double-Blind Method; Drug Interactions; Female; Humans; Imipramine; Kinetics; Nortriptyline; Protein Binding; Protriptyline | 1977 |
Plasma and erythrocyte levels of tricyclic antidepressants in depressed patients.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Biopharmaceutics; Clinical Trials as Topic; Depression; Desipramine; Doxepin; Erythrocytes; Humans; Imipramine; Middle Aged; Nortriptyline | 1978 |
A clinical trial comparing sustained release amitryptyline (Saroten Retard) and conventional amitriptyline tablets (Saroten) in endogenously depressed patients with simultaneous determination of serum levels of amitryptyline and nortriptyline.
Topics: Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Delayed-Action Preparations; Depression; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Middle Aged; Nortriptyline; Placebos; Psychiatric Status Rating Scales; Tablets | 1978 |
Amitriptyline nortriptyline plasma levels and therapeutic response in depressed women.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Female; Humans; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales | 1977 |
Clinical response and plasma concentration of amitriptyline and its metabolite nortriptyline.
Topics: Adult; Amitriptyline; Clinical Trials as Topic; Depression; Female; Humans; Male; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales | 1978 |
Changes in weight during treatment for depression.
Topics: Adult; Amitriptyline; Appetite; Body Weight; Depression; Female; Humans; Nortriptyline; Placebos | 1979 |
A comparison of amitriptyline and a fluphenazine/nortriptyline preparation in anxiety-depressive states.
Topics: Adolescent; Adult; Aged; Amitriptyline; Anxiety; Clinical Trials as Topic; Depression; Drug Combinations; Female; Fluphenazine; Humans; Male; Middle Aged; Nortriptyline | 1976 |
Treatment of anxiety/depressive conditions in the elderly: a double-blind comparative study of Motival and amitriptyline.
Topics: Aged; Amitriptyline; Anxiety Disorders; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Drug Combinations; Fluphenazine; Humans; Nortriptyline | 1975 |
Apparent pharmacokinetic interaction of diazepam and amitriptyline in psychiatric patients: a pilot study.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Diazepam; Drug Interactions; Half-Life; Humans; Kinetics; Male; Middle Aged; Nortriptyline; Pilot Projects; Protriptyline; Psychotic Disorders | 1975 |
A comparison study of amitriptyline and nortriptyline with plasma levels.
Topics: Administration, Oral; Adult; Amitriptyline; Depression; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Male; Nortriptyline | 1977 |
Once-daily treatment for mixed anxiety/depressive states: a comparison of slow release amitriptyline and fluphenazine with nortriptyline.
Topics: Adolescent; Adult; Aged; Amitriptyline; Anxiety; Depression; Drug Combinations; Fluphenazine; Humans; Middle Aged; Nortriptyline | 1977 |
Amitriptyline plasma levels and clinical response in primary depression.
Topics: Adult; Amitriptyline; Depression; Female; Humans; Male; Nortriptyline; Psychiatric Status Rating Scales; Time Factors | 1977 |
Effect of tricyclic antidepressants and alcohol in psychomotor skills related to driving.
Topics: Adult; Amitriptyline; Analysis of Variance; Antidepressive Agents, Tricyclic; Attention; Automobile Driving; Blood Pressure; Choice Behavior; Clinical Trials as Topic; Dose-Response Relationship, Drug; Doxepin; Drug Interactions; Ethanol; Humans; Motor Skills; Nortriptyline; Reaction Time; Time Factors; Tyramine | 1975 |
Relationship between parameters of serotonin transport and antidepressant plasma levels or therapeutic response in depressive patients treated with paroxetine and amitriptyline.
Topics: Adult; Amitriptyline; Antidepressive Agents; Blood Platelets; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Nortriptyline; Paroxetine; Piperidines; Psychiatric Status Rating Scales; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1992 |
[Plasma and urine kinetics of amitriptyline oxide and its metabolites. Comparison of intravenous infusion and oral administration in volunteers].
Topics: Administration, Oral; Adult; Amitriptyline; Biotransformation; Blood Pressure; Female; Humans; Infusions, Intravenous; Male; Nortriptyline; Pulse | 1991 |
Identifying the specific clinical actions of amitriptyline: interrelationships of behaviour, affect and plasma levels in depression.
Topics: Affect; Amitriptyline; Arousal; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Nortriptyline; Psychiatric Status Rating Scales; Sleep Stages; Social Behavior | 1991 |
Validation of a therapeutic plasma level range in amitriptyline treatment of depression.
Topics: Adolescent; Adult; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales | 1989 |
Antidepressant-induced weight gain: a comparison study of four medications.
Topics: Adult; Amitriptyline; Antidepressive Agents; Depressive Disorder; Desipramine; Female; Humans; Male; Middle Aged; Nortriptyline; Weight Gain; Zimeldine | 1988 |
Pharmacokinetics of amitriptyline influenced by oral charcoal and urine pH.
Topics: Administration, Oral; Adult; Amitriptyline; Ammonium Chloride; Bicarbonates; Charcoal; Female; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Kidney; Kinetics; Male; Nortriptyline; Random Allocation; Sodium; Sodium Bicarbonate | 1986 |
Dexamethasone suppression test status does not predict differential response to nortriptyline versus amitriptyline.
Topics: Adult; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Dexamethasone; Double-Blind Method; Female; Humans; Hydrocortisone; Male; Nortriptyline; Random Allocation | 1988 |
Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain.
Topics: Adult; Amitriptyline; Analgesics; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Nortriptyline; Pain; Random Allocation; Sex Characteristics; Time Factors | 1986 |
Treating delusional depressives with amitriptyline.
Topics: Adult; Amitriptyline; Bipolar Disorder; Clinical Trials as Topic; Delusions; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales | 1986 |
[Changes in slow evoked potentials in depressed patients treated with amitriptyline and oxaprotiline].
Topics: Adult; Amitriptyline; Anthracenes; Antidepressive Agents; Contingent Negative Variation; Depressive Disorder; Double-Blind Method; Electrophysiology; Evoked Potentials, Auditory; Female; Humans; Male; Maprotiline; Middle Aged; Nortriptyline; Random Allocation | 1987 |
Application of an individually predicted dosage of amitriptyline to the treatment of depression.
Topics: Adult; Amitriptyline; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nortriptyline; Parasympatholytics | 1987 |
The pharmacological treatment of delusional depression: Part II.
Topics: Amitriptyline; Delusions; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Humans; Nortriptyline; Perphenazine; Psychiatric Status Rating Scales; Random Allocation | 1986 |
Long-term amitriptyline in chronic depression.
Topics: Amitriptyline; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Nortriptyline; Recurrence; Substance Withdrawal Syndrome; Time Factors | 1985 |
Cimetidine interaction with amitriptyline.
Topics: Adult; Amitriptyline; Blood Pressure; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Humans; Male; Nortriptyline; Psychomotor Performance; Pulse; Random Allocation; Time Factors | 1985 |
Amitriptyline and hydroxylated metabolite plasma levels in depressed outpatients.
Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Humans; Kinetics; Middle Aged; Nortriptyline | 1985 |
[The use of low-dose amitriptyline in psychogeriatrics. A clinical, pharmacokinetic and pharmacogenetic study].
Topics: Aged; Amitriptyline; Debrisoquin; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Hydroxylation; Male; Nortriptyline; Psychological Tests | 1985 |
An evaluation of fluphenazine with nortriptyline in anxiety and depression.
Topics: Amitriptyline; Anxiety; Clinical Trials as Topic; Depression; Drug Combinations; Fluphenazine; Humans; Nortriptyline; Perphenazine; Placebos | 1972 |
Enuresis and psychoactive drugs.
Topics: Adolescent; Amitriptyline; Child; Child, Preschool; Chlordiazepoxide; Clinical Trials as Topic; Dibenzazepines; Enuresis; Female; Humans; Imipramine; Male; Nortriptyline; Placebos | 1972 |
Comparison of a combination nortriptyline-amitriptyline and placebo on gastrointestinal diseases in a controlled clinical study.
Topics: Adolescent; Adult; Amitriptyline; Clinical Trials as Topic; Drug Therapy, Combination; Dyspepsia; Humans; Male; Middle Aged; Nortriptyline; Peptic Ulcer | 1973 |
A review of clinical studies with combinations of fluphenazine and nortriptyline.
Topics: Amitriptyline; Anxiety; Central Nervous System; Clinical Trials as Topic; Depression; Diazepam; Doxepin; Drug Combinations; Fluphenazine; Heart Conduction System; Humans; Motor Activity; Nortriptyline; Perphenazine; Placebos; Psychiatric Status Rating Scales; Vision Disorders | 1972 |
Urinary excretion of amitriptyline N-oxide in humans.
Topics: Adult; Amitriptyline; Buffers; Clinical Trials as Topic; Female; Humans; Hydroxylation; Male; Nitrogen Oxides; Nortriptyline; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Time Factors | 1974 |
Therapy possibilities for therapy-resistant depressions.
Topics: Amitriptyline; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; Depression; Desipramine; Drug Resistance; Drug Therapy, Combination; Electroconvulsive Therapy; Humans; Imipramine; Nortriptyline; Remission, Spontaneous; Time Factors; Tranquilizing Agents | 1974 |
Lithium in the control of mania.
Topics: Adult; Amitriptyline; Bipolar Disorder; Chlorpromazine; Clinical Trials as Topic; Desipramine; Female; Humans; Imipramine; Lithium; Male; Middle Aged; Nortriptyline; Thioridazine; Tranylcypromine; Trifluoperazine | 1967 |
Double-blind comparison of nortriptyline and amitriptyline in depressive illness.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Female; Hospitals, Psychiatric; Humans; Male; Middle Aged; Nortriptyline; Placebos | 1967 |
Comparative trial of nortriptyline and amitriptyline in 100 depressed patients.
Topics: Amitriptyline; Analysis of Variance; Clinical Trials as Topic; Depression; Female; Humans; Male; Middle Aged; Nortriptyline; Placebos | 1968 |
Prediction in anti-depressant therapy.
Topics: Adjustment Disorders; Amitriptyline; Clinical Trials as Topic; Depression; Female; Humans; Male; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales; Time Factors | 1968 |
Verbal behaviour changes with depression treatment.
Topics: Adolescent; Adult; Amitriptyline; Analysis of Variance; Antidepressive Agents; Clinical Trials as Topic; Depression; Desipramine; Female; Humans; Imipramine; Interpersonal Relations; Interview, Psychological; Male; Middle Aged; Nortriptyline; Placebos; Psychiatric Status Rating Scales; Self Concept; Verbal Behavior | 1969 |
Are antidepressants better than placebo?
Topics: Adjustment Disorders; Adult; Aged; Amitriptyline; Antidepressive Agents; Anxiety; Clinical Trials as Topic; Depression; Dextroamphetamine; Diazepam; Dibenzocycloheptenes; Fatigue; Female; Humans; Male; Middle Aged; Nortriptyline; Perphenazine; Phenytoin; Placebos; Propylamines; Sleep; Xerostomia | 1971 |
A variable dose phase 3, human bioassay of nortriptyline.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Clinical Trials as Topic; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline | 1965 |
A comparative trial of nortriptyline and amitriptyline in chronic schizophrenia.
Topics: Aged; Amitriptyline; Antidepressive Agents; Clinical Trials as Topic; Female; Humans; Middle Aged; Nortriptyline; Schizophrenia | 1966 |
On the acute effect of drugs on artificial conditioned verbal associations.
Topics: Adolescent; Adult; Amitriptyline; Analysis of Variance; Ascorbic Acid; Association; Chlordiazepoxide; Conditioning, Psychological; Diazepam; Female; Humans; Male; Meprobamate; Nortriptyline; Phenytoin; Placebos; Pyridoxine; Riboflavin; Statistics as Topic; Thiamine; Verbal Behavior | 1970 |
[Comparative evaluation of nortriptyline, amitriptyline and of a placebo in the treatment of anxiety and depressive disorders].
Topics: Adult; Amitriptyline; Anxiety; Depression; Female; Humans; Mental Disorders; Middle Aged; Nortriptyline; Placebos | 1969 |
Amitriptyline: looking through the therapeutic window.
Topics: Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans; Kinetics; Nortriptyline | 1984 |
Tricyclic plasma levels in depressed outpatients treated with amitriptyline.
Topics: Amitriptyline; Caffeine; Depression; Female; Humans; Male; Nortriptyline; Smoking | 1983 |
The demethylation of amitriptyline: a cross-over study of steady-state plasma levels of amitriptyline and nortriptyline in depressed patients.
Topics: Aged; Amitriptyline; Biotransformation; Depressive Disorder; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Nortriptyline | 1983 |
Tricyclic-induced electroencephalogram abnormalities and plasma drug concentrations.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bupropion; Depressive Disorder; Double-Blind Method; Electroencephalography; Female; Humans; Male; Middle Aged; Nortriptyline; Propiophenones; Random Allocation | 1984 |
Amoxapine and amitriptyline: serum levels and clinical response in patients with primary unipolar depression.
Topics: Adolescent; Adult; Ambulatory Care; Amitriptyline; Amoxapine; Clinical Trials as Topic; Depressive Disorder; Dibenzoxazepines; Double-Blind Method; Humans; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales | 1982 |
Amitriptyline stimulates weight gain in hemodialysis patients.
Topics: Adult; Aged; Amitriptyline; Anorexia Nervosa; Blood Pressure; Body Weight; Clinical Trials as Topic; Depression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nortriptyline; Renal Dialysis | 1982 |
Amitriptyline pharmacokinetics. A crossover study with single doses of amitriptyline and nortriptyline.
Topics: Adult; Amitriptyline; Female; Food; Gastric Mucosa; Humans; Intestinal Absorption; Kinetics; Male; Nortriptyline; Tissue Distribution | 1981 |
Recurrence of depression after discontinuation of long-term amitriptyline treatment.
Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Female; Humans; Long-Term Care; Male; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales; Recurrence | 1982 |
Amitriptyline and nortriptyline response profiles in unipolar depressed patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales; Time Factors | 1982 |
A double-blind comparison of dothiepin and amitriptyline in patients with primary affective disorder: serum levels and clinical response.
Topics: Adult; Amitriptyline; Clinical Trials as Topic; Depression; Dibenzothiepins; Dothiepin; Double-Blind Method; Female; Humans; Male; Middle Aged; Nortriptyline | 1980 |
Pharmacokinetics and clinical response to tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Humans; Imipramine; Kinetics; Nortriptyline | 1980 |
The treatment of depression in general practice: a comparison of L-tryptophan, amitriptyline, and a combination of L-tryptophan and amitriptyline with placebo.
Topics: Adolescent; Adult; Aged; Amitriptyline; Depressive Disorder; Drug Therapy, Combination; Family Practice; Female; Humans; Male; Middle Aged; Nortriptyline; Tryptophan | 1982 |
Amitriptyline metabolism in elderly depressed patients and normal controls in relation to hypothalamic-pituitary-adrenal system function.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Dexamethasone; Female; Humans; Hypothalamo-Hypophyseal System; Male; Middle Aged; Nortriptyline; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System; Psychiatric Status Rating Scales; Sex Characteristics | 1995 |
Pruritus caused by 3-hour infusion of high-dose paclitaxel and improvement with tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Breast Neoplasms; Humans; Infusions, Intravenous; Nortriptyline; Paclitaxel; Pruritus | 1995 |
Steady-state kinetics of fluoxetine and amitriptyline in patients treated with a combination of these drugs as compared with those treated with amitriptyline alone.
Topics: Adolescent; Adult; Amitriptyline; Bipolar Disorder; Chromatography, High Pressure Liquid; Depression; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Metabolic Clearance Rate; Middle Aged; Nortriptyline | 1995 |
Blood levels of mianserin and amitriptyline and clinical response in aged depressed patients.
Topics: Aged; Aged, 80 and over; Aging; Amitriptyline; Chromatography, High Pressure Liquid; Depressive Disorder; Humans; Male; Mianserin; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales; Single-Blind Method | 1994 |
[Comparative study of the pharmacokinetics of amitriptyline oxide and trimipramine after single administration in healthy male probands and patients with renal failure].
Topics: Adult; Aged; Amitriptyline; Humans; Kidney Failure, Chronic; Male; Metabolic Clearance Rate; Middle Aged; Nortriptyline; Trimipramine | 1993 |
Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Anxiety; Breast Neoplasms; Cross-Over Studies; Depression; Double-Blind Method; Female; Humans; Mastectomy; Middle Aged; Nortriptyline; Pain Measurement; Pain, Postoperative; Quality of Life | 1996 |
Nortriptyline versus amitriptyline in postherpetic neuralgia: a randomized trial.
Topics: Aged; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Cross-Over Studies; Depression; Double-Blind Method; Follow-Up Studies; Herpes Zoster; Humans; Middle Aged; Neuralgia; Nortriptyline; Oxycodone; Sleep | 1998 |
Food intake and the presystemic metabolism of single doses of amitriptyline and nortriptyline.
Topics: Adult; Amitriptyline; Eating; Female; Food-Drug Interactions; Humans; Middle Aged; Nortriptyline | 1998 |
[The bioequivalence of a new amitriptyline tablet formulation in comparison with a reference preparation].
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Area Under Curve; Biotransformation; Cross-Over Studies; Humans; Male; Nortriptyline; Therapeutic Equivalency | 1998 |
Management of chronic tension-type headache with tricyclic antidepressant medication, stress management therapy, and their combination: a randomized controlled trial.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Behavior Therapy; Chronic Disease; Cognitive Behavioral Therapy; Combined Modality Therapy; Female; Humans; Male; Nortriptyline; Relaxation Therapy; Stress, Psychological; Tension-Type Headache | 2001 |
Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Female; Humans; Isoenzymes; Ketoconazole; Male; Metabolic Clearance Rate; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Nortriptyline; Oxidoreductases, N-Demethylating; Phenotype | 2001 |
The role of CYP2C19 in amitriptyline N-demethylation in Chinese subjects.
Topics: Administration, Oral; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Area Under Curve; Aryl Hydrocarbon Hydroxylases; China; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Genotype; Half-Life; Humans; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Nortriptyline; Polymerase Chain Reaction | 2002 |
Antidepressants do not have better results than placebo in the treatment of fibromyalgia in Brazil.
Topics: Amitriptyline; Antidepressive Agents; Double-Blind Method; Drug Administration Schedule; Female; Fibromyalgia; Humans; Male; Nortriptyline; Pain Measurement; Prognosis; Reference Values; Treatment Outcome | 2002 |
Predictors of therapeutic effects in amitriptyline treatment--1. Plasma drug levels.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Data Interpretation, Statistical; Depressive Disorder, Major; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nortriptyline; Time Factors; Treatment Outcome | 2003 |
Amitriptyline or not, that is the question: pharmacogenetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Depressive Disorder; Female; Genotype; Humans; Male; Middle Aged; Mixed Function Oxygenases; Nortriptyline; Pharmacogenetics; Risk; ROC Curve | 2005 |
Equivalency of tricyclic antidepressants in open-label neuropathic pain study.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Neuralgia; Nortriptyline; Pain Measurement; Peripheral Nervous System Diseases; Therapeutic Equivalency; Treatment Outcome; Treatment Refusal | 2014 |
Pharmacokinetics of intravenous and oral amitriptyline and its active metabolite nortriptyline in Greyhound dogs.
Topics: Administration, Oral; Amitriptyline; Analgesics; Animals; Biological Availability; Dogs; Female; Half-Life; Injections, Intravenous; Male; Nortriptyline | 2015 |
Myofascial pain: an open study on the pharmacotherapeutic response to stepped treatment with tricyclic antidepressants and gabapentin.
Topics: Adult; Age Factors; Amines; Amitriptyline; Antidepressive Agents, Tricyclic; Comorbidity; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Masticatory Muscles; Medical Records; Middle Aged; Myalgia; Neck Muscles; Nortriptyline; Pain Measurement; Palpation; Prospective Studies; Temporomandibular Joint Dysfunction Syndrome; Treatment Outcome; Young Adult | 2015 |
Evaluation of the pharmacokinetics of oral amitriptyline and its active metabolite nortriptyline in fed and fasted Greyhound dogs.
Topics: Administration, Oral; Amitriptyline; Animals; Biological Availability; Cross-Over Studies; Dogs; Eating; Fasting; Female; Male; Nortriptyline | 2015 |
A Study on CYP2C19 and CYP2D6 Polymorphic Effects on Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Koreans.
Topics: Adrenergic Uptake Inhibitors; Adult; Alleles; Amitriptyline; Antidepressive Agents, Tricyclic; Asian People; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Double-Blind Method; Gene Frequency; Genotype; Healthy Volunteers; Humans; Male; Nortriptyline; Polymorphism, Genetic; Practice Guidelines as Topic; Republic of Korea; Young Adult | 2017 |
580 other study(ies) available for amitriptyline and nortriptyline
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Homoallylic amines related to zimeldine. A comparative study on neuronal serotonin and norepinephrine reuptake based on conformational analysis.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; In Vitro Techniques; Male; Mice; Neurotransmitter Uptake Inhibitors; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism; Structure-Activity Relationship; Synaptosomes; Zimeldine | 1988 |
2,4-Dihydro-3H-1,2,4-triazole-3-thiones as potential antidepressant agents.
Topics: Animals; Antidepressive Agents; Desipramine; gamma-Aminobutyric Acid; Male; Mice; Monoamine Oxidase Inhibitors; Norepinephrine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Triazoles | 1988 |
Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity.
Topics: Amines; Animals; Buffers; Chromatography, High Pressure Liquid; Histamine Release; Lipid Metabolism; Octanols; Protein Binding; Rats; Serum Albumin, Bovine; Sodium-Potassium-Exchanging ATPase; Solubility; Structure-Activity Relationship | 1981 |
Antiarrhythmic activity of amitriptyline analogues in conscious dogs after myocardial infarction: cyproheptadinium methiodide.
Topics: Amitriptyline; Animals; Anti-Arrhythmia Agents; Cyproheptadine; Dogs; Hemodynamics; Myocardial Infarction | 1980 |
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ligands; Models, Molecular; Pyrilamine; Radioligand Assay; Structure-Activity Relationship; Tetrahydronaphthalenes | 1999 |
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.
Topics: Adenylyl Cyclase Inhibitors; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Enzyme Inhibitors; Histamine H1 Antagonists; Micelles; Models, Biological; Norepinephrine; Rats; Receptors, Adrenergic, alpha-1; Selective Serotonin Reuptake Inhibitors; Serotonin; Structure-Activity Relationship | 1999 |
Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption.
Topics: Amitriptyline; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Chromatography, High Pressure Liquid; Fluoxetine; Male; Mice; Mice, Knockout | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Electrophysiology; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Heart; Humans; Myocardium; Oocytes; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Xenopus laevis | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds.
Topics: Antimalarials; Astemizole; Dose-Response Relationship, Drug; Humans; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship; Transcriptional Regulator ERG | 2017 |
Inhibition of N-type calcium ion channels by tricyclic antidepressants - experimental and theoretical justification for their use for neuropathic pain.
Topics: | 2022 |
Substrates and Inhibitors of the Organic Cation Transporter 3 and Comparison with OCT1 and OCT2.
Topics: Biological Transport; Cations; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2 | 2022 |
On the biological half-life of amitroptyline.
Topics: Adult; Amitriptyline; Female; Half-Life; Humans; Male; Middle Aged; Nortriptyline | 1976 |
Tricyclic antidepressants and histamine H1 receptors.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Atropine; Benztropine; Cells, Cultured; Clozapine; Cyproheptadine; Desipramine; Doxepin; Haloperidol; Histamine H1 Antagonists; Hydroxyzine; Imipramine; Mice; Neoplasms, Experimental; Neuroblastoma; Nortriptyline; Protriptyline; Receptors, Histamine; Receptors, Histamine H1; Receptors, Muscarinic | 1979 |
Novel 125I-labeled nortriptyline derivatives and their use in liquid-phase or magnetizable solid-phase second-antibody radioimmunoassays.
Topics: Amitriptyline; Cross Reactions; Fluoresceins; Histidine; Humans; Hydrogen-Ion Concentration; Iodine Radioisotopes; Isotope Labeling; Magnetics; Nortriptyline; Radioimmunoassay; Thiocyanates | 1979 |
Interaction between amitriptyline and phenothiazine in man: effect on plasma concentration of amitriptyline and its metabolite nortriptyline and the correlation with clinical response.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antipsychotic Agents; Depression; Drug Interactions; Female; Humans; Male; Middle Aged; Nortriptyline; Phenothiazines | 1979 |
Effects of tricyclic antidepressants on drug metabolism.
Topics: Adult; Amitriptyline; Dicumarol; Half-Life; Humans; Kinetics; Male; Nortriptyline; Pharmaceutical Preparations; Phenytoin; Time Factors; Tolbutamide; Warfarin | 1975 |
Letter: Do tricyclic antidepressants work?
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Humans; Nortriptyline | 1976 |
Radioimmunoassay for nortriptyline and amitriptyline.
Topics: Amitriptyline; Humans; Imipramine; Nortriptyline; Radioimmunoassay; Tritium | 1977 |
Radioimmunoassay for nortriptyline and amitryptyline.
Topics: Amitriptyline; Humans; Nortriptyline; Radioimmunoassay | 1977 |
Amitriptyline and its demethylation-rate.
Topics: Adult; Aged; Amitriptyline; Depression; Humans; Middle Aged; Nortriptyline | 1978 |
Amitriptyline and its demethylation-rate.
Topics: Amitriptyline; Biological Availability; Dose-Response Relationship, Drug; Humans; Methylation; Nortriptyline | 1979 |
Interactions of tricyclic antidepressant drugs with deprivation-induced fluid consumption by rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Doxepin; Drinking Behavior; Fenclonine; Imipramine; Male; Methyltyrosines; Nortriptyline; Protriptyline; Rats; Water Deprivation | 1977 |
EEG sleep and tricyclic plasma levels in primary depression.
Topics: Adult; Amitriptyline; Depression; Dose-Response Relationship, Drug; Electroencephalography; Female; Humans; Male; Nortriptyline; Sleep, REM | 1979 |
The role of plasma level monitoring of tricyclic antidepressant drugs as an aid to treatment.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline | 1979 |
A method for the determination of amitriptyline and its metabolites nortriptyline, 10-hydroxyamitriptyline, and 10-hydroxynortriptyline in human plasma using stable isotope dilution and gas chromatography-chemical ionization mass spectrometry (GC-CIMS).
Topics: Amitriptyline; Chromatography, Gas; Dealkylation; Deuterium; Half-Life; Humans; Hydroxylation; Indicator Dilution Techniques; Kinetics; Male; Mass Spectrometry; Mathematics; Methods; Nortriptyline | 1979 |
Metabolic interaction between amitriptyline and perphenazine in psychiatric patients.
Topics: Adult; Amitriptyline; Drug Interactions; Female; Humans; Male; Middle Aged; Nortriptyline; Perphenazine; Random Allocation; Schizophrenia | 1979 |
Noradrenaline, depressive illness, and the action of amitriptyline.
Topics: Adult; Aged; Amitriptyline; Blood Pressure; Depression; Female; Humans; Male; Middle Aged; Norepinephrine; Nortriptyline; Tyramine | 1977 |
Amitriptyline plasma concentration and clinical response.
Topics: Amitriptyline; Depression; Humans; Nortriptyline | 1979 |
Relationship between surface activity and toxicity to Chang liver cultures of tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Cells, Cultured; Clomipramine; Doxepin; Glucuronidase; Humans; Imipramine; L-Lactate Dehydrogenase; Liver; Nortriptyline; Surface Tension | 1979 |
Chronic amitriptyline toxicity.
Topics: Amitriptyline; Depression; Humans; Liver; Male; Middle Aged; Nortriptyline | 1979 |
Cardiovascular side effects of long-term therapy with tricyclic antidepressants in the aged.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular System; Electrocardiography; Female; Heart Block; Heart Failure; Humans; Imipramine; Male; Myocardial Infarction; Nortriptyline; Thiothixene | 1979 |
Monitoring tricyclic antidepressant plasma concentrations.
Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Humans; Imipramine; Nortriptyline | 1979 |
Specific radioimmunoassay of amitriptyline and nortriptyline.
Topics: Amitriptyline; Animals; Antibody Formation; Antibody Specificity; Cattle; Chromatography, Gas; Methods; Nortriptyline; Rabbits; Radioimmunoassay | 1979 |
Rapid intramuscular administration of tricyclic antidepressants.
Topics: Adjustment Disorders; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depression; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Injections, Intramuscular; Male; Methylphenidate; Middle Aged; Nortriptyline; Suicide, Attempted | 1979 |
Amitriptyline plasma concentrations and clinical response.
Topics: Amitriptyline; Depression; Dose-Response Relationship, Drug; Humans; Nortriptyline; Psychiatric Status Rating Scales | 1979 |
The effects of antihistamines in a modified behavioral despair test.
Topics: Amitriptyline; Animals; Behavior, Animal; Histamine Antagonists; Imipramine; Immersion; Male; Mice; Motor Activity; Nortriptyline | 1979 |
The effect of tricyclic antidepressants on cerebral fluid dynamics.
Topics: Amitriptyline; Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Male; Nortriptyline; Protriptyline; Rats; Receptors, Adrenergic; Water | 1979 |
Guidelines for clinical use in interpreting tricyclic plasma levels.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Dose-Response Relationship, Drug; Humans; Imipramine; Maprotiline; Nortriptyline | 1979 |
The effect of tricyclic antidepressants (TA) on the circulatory system in primary arterial hypertension.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Catecholamines; Hemodynamics; Humans; Hypertension; Imipramine; Nortriptyline | 1979 |
Tricyclics and breast feeding.
Topics: Amitriptyline; Female; Humans; Infant, Newborn; Milk, Human; Nortriptyline; Pregnancy | 1979 |
Amitriptyline overdosage: plasma concentrations and clinical features [proceedings].
Topics: Adolescent; Adult; Aged; Amitriptyline; Child; Humans; Middle Aged; Nortriptyline | 1979 |
Pronounced inhibition of noradrenaline uptake by 10-hydroxymetabolites of nortriptyline.
Topics: Amitriptyline; Animals; Biological Transport; Brain; Gas Chromatography-Mass Spectrometry; Humans; Norepinephrine; Nortriptyline; Personality Disorders; Rats; Serotonin | 1979 |
Enhancement of morphine analgesia by tricyclic antidepressants.
Topics: Amitriptyline; Analgesia; Animals; Antidepressive Agents, Tricyclic; Cats; Drug Synergism; Male; Morphine; Nortriptyline; Reaction Time; Time Factors | 1979 |
Reliable routine method for the determination of plasma amitriptyline and nortriptyline by gas chromatography.
Topics: Amitriptyline; Chromatography, Gas; Humans; Microchemistry; Nortriptyline; Pharmaceutical Preparations | 1979 |
An improved gas-liquid chromatographic procedure for the determination of amitriptyline and nortriptyline levels in plasma using nitrogen-sensitive detectors.
Topics: Amitriptyline; Chromatography, Gas; Humans; Nitrogen; Nortriptyline; Reference Standards | 1979 |
Radioimmunoassay of amitriptyline and nortriptyline in body fluids.
Topics: Amitriptyline; Animals; Cross Reactions; Humans; Imipramine; Nortriptyline; Radioimmunoassay; Saliva; Sheep | 1978 |
Tricyclic antidepressant overdose: incidence of symptoms.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Doxepin; Electrocardiography; Heart; Humans; Imipramine; Nortriptyline | 1977 |
Serum gonadotropin and TSH levels after tricyclic antidepressants in healthy males.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Doxepin; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Nortriptyline; Secretory Rate; Thyrotropin | 1977 |
Tricyclic plasma levels. Effect of age, race, sex, and smoking.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Black People; Depression; Female; Humans; Male; Nortriptyline; Smoking; White People | 1977 |
Correlations between serum ami- and nortriptyline concentrations and psychomotor performance.
Topics: Adult; Amitriptyline; Chromatography, Gas; Chromatography, Thin Layer; Humans; Motor Skills; Nortriptyline; Reaction Time | 1977 |
Gas chromatographic determination of amitriptyline, nortriptyline and perphenazine in plasma of schizophrenic patients after administration of the combination of amitriptyline with perphenazine.
Topics: Adult; Amitriptyline; Chromatography, Gas; Drug Combinations; Female; Humans; Male; Middle Aged; Nortriptyline; Perphenazine; Schizophrenia | 1979 |
High serum concentrations of antidepressants in elderly patients.
Topics: Aged; Amitriptyline; Depression; Female; Humans; Male; Middle Aged; Nortriptyline | 1977 |
Metabolism and pharmacokinetics of clomipramine. Measurement of plasma antidepressant levels by high-performance liquid chromatography.
Topics: Amitriptyline; Chromatography, Gas; Chromatography, High Pressure Liquid; Clomipramine; Dibenzazepines; Humans; Nortriptyline | 1977 |
Cocaine-related death.
Topics: Adolescent; Adult; Amitriptyline; Amphetamines; Brain Edema; Cocaine; Ethanol; Female; Forensic Medicine; Humans; Intracranial Aneurysm; Lidocaine; Male; Morphine; Nortriptyline; Phenmetrazine; Substance-Related Disorders; Suicide; Tissue Distribution | 1977 |
Liquid-chromatographic procedure for tricyclic drugs and their metabolites in plasma.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Desipramine; Humans; Imipramine; Nortriptyline | 1978 |
Haemoperfusion in treatment of drug intoxication.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Hemoperfusion; Humans; Nortriptyline; Resins, Synthetic | 1978 |
A radioimmunoassay for the determination of combined amitriptyline and nortriptyline concentrations in microliter samples of plasma.
Topics: Amitriptyline; Humans; Methods; Microchemistry; Nortriptyline; Radioimmunoassay | 1978 |
Determination of amitriptyline and nortriptyline in human plasma by quantitative thin-layer chromatography.
Topics: Amitriptyline; Chromatography, Thin Layer; Densitometry; Humans; Nortriptyline | 1978 |
A radioimmunoassay for amitriptyline and nortriptyline [proceedings].
Topics: Amitriptyline; Humans; Methods; Nortriptyline; Radioimmunoassay | 1978 |
Sympathetic nervous system response in acute cardiovascular toxicity induced by amitriptyline in conscious rabbits.
Topics: Amitriptyline; Animals; Blood Pressure; Body Temperature; Cardiovascular Diseases; Catecholamines; Electrocardiography; Female; Hemodynamics; Kidney Diseases; Male; Nortriptyline; Rabbits; Sympathetic Nervous System; Time Factors | 1978 |
Determination of drugs in plasma by high-performance thin-layer chromatography.
Topics: Amitriptyline; Chlorpromazine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Desipramine; Humans; Imipramine; Nortriptyline; Phenobarbital; Phenytoin; Psychotropic Drugs; Spectrophotometry, Ultraviolet | 1978 |
Tricyclic antidepressant concentrations and clinical response.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Humans; Nortriptyline | 1978 |
Ion-pair liquid chromatography of amitriptyline and metabolites in plasma.
Topics: Amitriptyline; Chromatography, Ion Exchange; Chromatography, Liquid; Humans; Nortriptyline; Stereoisomerism | 1978 |
Tricyclic antidepressants: plasma levels and clinical findings in overdose.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Electrocardiography; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline | 1978 |
High-performance liquid-chromatographic simultaneous determination of commonly used tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline | 1978 |
Contribution to the pharmacokinetics of amitriptyline.
Topics: Adult; Amitriptyline; Female; Half-Life; Humans; Kinetics; Male; Nortriptyline; Time Factors | 1978 |
Hemoperfusion in the treatment of amitriptyline intoxication.
Topics: Adult; Amitriptyline; Female; Hemoperfusion; Humans; Nortriptyline | 1978 |
The kinetics of amitriptyline following single oral dose administration to man.
Topics: Adult; Amitriptyline; Half-Life; Humans; Kinetics; Male; Nortriptyline | 1978 |
Amitriptyline plasma levels and clinical response in primary depression: II.
Topics: Adult; Amitriptyline; Chromatography, Gas; Depression; Female; Humans; Male; Mass Spectrometry; Methods; Nortriptyline; Psychiatric Status Rating Scales; Time Factors | 1978 |
[Blood levels of tricyclics and evolution of depressive syndrome during therapy].
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Humans; Imipramine; Nortriptyline | 1978 |
The absorption rate and bioavailability of amitriptyline in the form of Lentizol.
Topics: Amitriptyline; Biological Availability; Delayed-Action Preparations; Female; Humans; Intestinal Absorption; Kinetics; Male; Nortriptyline | 1978 |
Depression during renal dialysis and following transplantation.
Topics: Amitriptyline; Depression; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Nortriptyline; Postoperative Complications; Renal Dialysis; Transplantation, Homologous | 1976 |
Tricyclic antidepressants and cardiac conduction: changes in ventricular automaticity.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Dogs; Female; Heart Atria; Heart Conduction System; Heart Rate; Heart Ventricles; Imipramine; Male; Nitroglycerin; Nortriptyline | 1976 |
Quantitative determination of amitriptyline and nortriptyline in plasma by high-performance liquid chromatography.
Topics: Amitriptyline; Chromatography, High Pressure Liquid; Humans; Methods; Nortriptyline | 1977 |
Quantitative determination of amitriptyline and its principal metabolite, nortriptyline, by GLC-chemical ionization mass spectrometry.
Topics: Adult; Amitriptyline; Chromatography, Gas; Humans; Mass Spectrometry; Methods; Nortriptyline; Time Factors | 1977 |
Simultaneous determination of plasma amitriptyline and nortriptyline as trichloroethyl carbamates by electron-capture gas chromatography.
Topics: Amitriptyline; Carbamates; Chromatography, Gas; Nortriptyline | 1977 |
Assay of tricyclic structured drugs and their metabolites in urine by high-performance liquid chromatography.
Topics: Amitriptyline; Chlorpromazine; Chromatography, High Pressure Liquid; Dibenzocycloheptenes; Humans; Imipramine; Nortriptyline; Protriptyline | 1977 |
Relationship between age and tricyclic antidepressant plasma levels.
Topics: Administration, Oral; Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Body Weight; Depression; Desipramine; Female; Half-Life; Heart; Humans; Imipramine; Male; Middle Aged; Nortriptyline | 1977 |
Quantitation of amitriptyline and nortriptyline in human serum.
Topics: Amitriptyline; Chromatography, Gas; Dealkylation; Doxepin; Humans; Maprotiline; Nortriptyline | 1977 |
Rapid, sensitive gas-liquid chromatographic method for determination of amitryptyline and nortriptyline in plasma using a nitrogen-sensitive detector.
Topics: Amitriptyline; Chromatography, Gas; Humans; Indicators and Reagents; Microchemistry; Nitrogen; Nortriptyline; Structure-Activity Relationship | 1977 |
Separation and measurement of tricyclic antidepressant in plasma by high-performance liquid chromatography.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Humans; Methods; Nortriptyline | 1977 |
Tricyclic antidepressants as antimuscarinic drugs: in vivo and in vitro studies.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Body Temperature; Brain; Cholinesterase Inhibitors; Imipramine; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Nortriptyline; Parasympatholytics; Pupil; Receptors, Muscarinic; Scopolamine; Time Factors; Tremor | 1977 |
Electrocardiographic findings in patients undergoing amitriptyline treatment.
Topics: Adolescent; Adult; Amitriptyline; Depression; Electrocardiography; Female; Humans; Male; Middle Aged; Nortriptyline | 1977 |
Specific radioimmunoassay for amitriptyline and nortriptyline in plasma.
Topics: Amitriptyline; Antibody Specificity; Chromatography, Gas; Evaluation Studies as Topic; Mass Spectrometry; Methods; Nortriptyline; Radioimmunoassay | 1977 |
Studies of excretion in rabbit milk after administration of carbon-14 labelled amitriptyline and nortriptyline.
Topics: Amitriptyline; Animals; Animals, Newborn; Carbon Radioisotopes; Chromatography, Thin Layer; Female; Milk; Nortriptyline; Rabbits; Time Factors | 1977 |
Amitriptyline dosage schedule, sampling time and tricyclic plasma levels.
Topics: Amitriptyline; Depression; Drug Administration Schedule; Humans; Nortriptyline; Time Factors | 1977 |
High-performance thin-layer chromatographic determination of psychopharmacologic agents in blood serum.
Topics: Amitriptyline; Chlorpromazine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Desipramine; Humans; Imipramine; Methods; Nortriptyline; Psychotropic Drugs; Spectrophotometry, Ultraviolet | 1977 |
Amitriptyline blood levels and relapse.
Topics: Administration, Oral; Adult; Amitriptyline; Bipolar Disorder; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nortriptyline; Recurrence; Time Factors | 1977 |
[Complex rhodanate salts as precipitating reagents in assaying organic bases. IV. Use of potassium hexarhodanodiammochromate (III) and ammonium tetrarhodanodiammochromate (III) for assaying amitriptyline and other dibenzocycloheptene derivatives].
Topics: Amitriptyline; Chemical Phenomena; Chemical Precipitation; Chemistry; Dibenzocycloheptenes; Indicators and Reagents; Nortriptyline; Potassium Dichromate; Protriptyline; Quaternary Ammonium Compounds; Thiocyanates | 1976 |
Effect of flupenthixol on depression with special reference to combination use with tricyclic antidepressants. An uncontrolled pilot study with 45 patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Clomipramine; Depression; Drug Evaluation; Drug Therapy, Combination; Female; Flupenthixol; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Pilot Projects; Thioxanthenes; Trimipramine | 1976 |
Simultaneous determination of therapeutic levels of amitriptyline and nortriptyline in plasma by gas-liquid chromatography.
Topics: Amitriptyline; Chromatography, Gas; Chromatography, Liquid; Dose-Response Relationship, Drug; Humans; Methods; Nortriptyline | 1976 |
Measurement of plasma levels of tricylic psychoactive drugs and their metabolites by UV reflectance photometry of thin layer chromatograms.
Topics: Amitriptyline; Chromatography, Thin Layer; Clozapine; Desipramine; Humans; Imipramine; Methods; Nortriptyline; Perazine; Psychotropic Drugs; Spectrophotometry, Ultraviolet | 1976 |
Cardiac effects of different tricyclic antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Bundle of His; Doxepin; Electrocardiography; Heart Conduction System; Heart Rate; Humans; Imipramine; Nortriptyline; Substance-Related Disorders | 1976 |
A sensitive method for the determination of amitriptyline and nortriptyline in human plasma.
Topics: Adult; Amitriptyline; Chromatography, Gas; Humans; Male; Methods; Nortriptyline; Time Factors | 1976 |
The separation of some tricyclic antidepressants by high-performance liquid chromatography.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Clomipramine; Desipramine; Imipramine; Microchemistry; Nortriptyline; Protriptyline; Trimipramine | 1976 |
The influence of some antidepressant drugs on cardiac function. III. Influence on the isolated heart and isolated coronary blood vessels.
Topics: Amitriptyline; Animals; Cats; Coronary Circulation; Coronary Vessels; Dose-Response Relationship, Drug; Heart; Imipramine; Myocardial Contraction; Nortriptyline | 1976 |
The influence of some antidepressant drugs on cardiac function. IV. Influence of blood supply of the heart in situ.
Topics: Amitriptyline; Animals; Cats; Coronary Circulation; Dose-Response Relationship, Drug; Female; Heart; Heart Rate; Imipramine; Male; Myocardial Contraction; Nortriptyline | 1976 |
Tricyclic antidepressants and depletion of brain catecholamines. Preclinical and clinical studies with L-DOPA [proceedings].
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brain; Depression; Dopamine; Humans; Levodopa; Norepinephrine; Nortriptyline; Rats | 1976 |
The risk of potentiating effect of local anaesthesia with adrenalin in patients treated with tricyclic antidepressants.
Topics: Adult; Aged; Amitriptyline; Anesthesia, Local; Blood Pressure; Drug Interactions; Epinephrine; Female; Humans; Imipramine; Lidocaine; Male; Membranes; Middle Aged; Nortriptyline; Pulse; Time Factors | 1975 |
Assessment of cardiovascular side effects of therapeutic doses of tricyclic anti-depressant drugs.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Blood Pressure; Depression, Chemical; Doxepin; Electrocardiography; Female; Heart Conduction System; Heart Rate; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Physical Exertion; Stimulation, Chemical | 1975 |
[Modifications induced by antidepressant drugs on the vestibulo-ocular reflex in man].
Topics: Amitriptyline; Antidepressive Agents; Eye Movements; Humans; Imipramine; Nortriptyline; Phenelzine; Reflex; Reflex, Oculocardiac; Trazodone; Vestibule, Labyrinth | 1975 |
Letter: Effective dosage of tricyclic antidepressants.
Topics: Amitriptyline; Depression; Dose-Response Relationship, Drug; Humans; Nortriptyline | 1975 |
Patterns of symptom change in anxious depressed outpatients treated with different drugs.
Topics: Amitriptyline; Antidepressive Agents; Anxiety; Chlordiazepoxide; Chlorpromazine; Depression; Desipramine; Diazepam; Drug Combinations; Fluphenazine; Humans; Imipramine; Mental Disorders; Nortriptyline; Perphenazine; Thioridazine; Thiothixene; Tranquilizing Agents; Trifluoperazine | 1975 |
Spectrophotometric and gas-liquid chromatographic determination of amitriptyline.
Topics: Amitriptyline; Chromatography, Gas; Humans; Methods; Nortriptyline; Spectrophotometry, Ultraviolet | 1975 |
Separation and quantitative determination of tricyclic antidepressants by high-performance liquid chromatography.
Topics: Amitriptyline; Chromatography; Dibenzocycloheptenes; Nortriptyline; Protriptyline; Solvents | 1975 |
Interactions of tricyclic antidepressants and barbiturates in barbiturate-tolerant and nontolerant rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Barbiturates; Brain Chemistry; Desipramine; Drug Interactions; Drug Tolerance; Imipramine; Male; Microsomes, Liver; Nortriptyline; Pentobarbital; Rats; Sleep; Time Factors | 1975 |
Determination of amitriptyline at nanogram levels in serum by electron capture gas-liquid chromatography.
Topics: Amitriptyline; Chromatography, Gas; Humans; Methods; Microchemistry; Nortriptyline | 1975 |
[Effect of amitriptyline and nortriptyline on the intracular pressure and aqueous humor dynamics in rabbits (author's transl)].
Topics: Amitriptyline; Animals; Aqueous Humor; Drug Synergism; Female; Intraocular Pressure; Male; Norepinephrine; Nortriptyline; Pupil; Rabbits; Stimulation, Chemical | 1975 |
Influence of tricyclic antidepressant drugs on experimental arterial hypertension.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Corticosterone; Female; Hexobarbital; Hypertension; Imipramine; Kidney; Male; Nephrectomy; Nortriptyline; Opipramol; Rats | 1975 |
A gas chromatographic method for the determination of amitriptyline and nortriptyline in human serum.
Topics: Adult; Amitriptyline; Chromatography, Gas; Humans; Male; Methods; Nortriptyline; Time Factors | 1975 |
[Effect of prothixen and related compounds on serotonin absorption by human thrombocytes].
Topics: Absorption; Amitriptyline; Biological Transport; Blood Platelets; Cell Membrane Permeability; Chlorpromazine; Clomipramine; Depression, Chemical; Desipramine; Humans; Imipramine; In Vitro Techniques; Nortriptyline; Serotonin; Structure-Activity Relationship; Thioxanthenes; Triazines | 1975 |
Cardiovascular effects of amitriptyline, nortriptyline, protriptyline, and doxepin in conscious rabbits after subacute pretreatment with protriptyline.
Topics: Amitriptyline; Animals; Blood Pressure; Dibenzocycloheptenes; Doxepin; Electrocardiography; Heart Rate; Norepinephrine; Nortriptyline; Protriptyline; Rabbits; Tyramine | 1975 |
Biogenic amines and depression. Biochemical and pharmacological separation of two types of depression.
Topics: Amitriptyline; Biogenic Amines; Depression; Desipramine; Dextroamphetamine; Humans; Hydroxyindoleacetic Acid; Imipramine; Metanephrine; Methoxyhydroxyphenylglycol; Normetanephrine; Nortriptyline; Vanilmandelic Acid | 1975 |
Effect of fenfluramine on steady state plasma levels of amitriptyline.
Topics: Adult; Amitriptyline; Female; Fenfluramine; Humans; Male; Middle Aged; Nortriptyline | 1975 |
Influence of some antidepressant drugs on the circulatory system: II. Action of amitriptyline and nortriptyline on basic circulatory parameters.
Topics: Amitriptyline; Animals; Atropine; Cats; Dihydroergotamine; Hemodynamics; In Vitro Techniques; Muscle, Smooth; Myocardial Contraction; Norepinephrine; Nortriptyline; Propranolol; Quaternary Ammonium Compounds; Rabbits; Respiration | 1975 |
[Postsynaptic attack of tricyclic antidepressive agents in the circulatory system].
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Dose-Response Relationship, Drug; Female; Heart; Hemodynamics; Imipramine; Male; Norepinephrine; Nortriptyline; Opipramol; Rabbits; Rats; Receptors, Drug | 1975 |
Concentration of tricyclic antidepressants in plasma, heart and skeletal muscle after their intravenous infusion to anaesthetized rabbits.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Doxepin; Infusions, Parenteral; Muscles; Myocardium; Nortriptyline; Protriptyline; Rabbits | 1975 |
Gas-chromatographic analysis for therapeutic concentrations of amitriptyline and nortriptyline in plasma, with use of a nitrogen detector.
Topics: Amitriptyline; Chromatography, Gas; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Humans; Microchemistry; Nitrogen; Nortriptyline | 1976 |
Column switching and high-performance liquid chromatography in the analysis of amitriptyline, nortriptyline and hydroxylated metabolites in human plasma or serum.
Topics: Amitriptyline; Chromatography, High Pressure Liquid; Humans; Hydroxylation; Nortriptyline; Psychotropic Drugs; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1992 |
Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes.
Topics: Adult; Amitriptyline; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Humans; Isoenzymes; Male; Mephenytoin; Metabolic Clearance Rate; Middle Aged; Nortriptyline; Phenotype; Regression Analysis; Stereoisomerism | 1992 |
On-line solid-phase extraction and high-performance liquid chromatographic determination of nortriptyline and amitriptyline in serum.
Topics: Amitriptyline; Chromatography, High Pressure Liquid; Humans; Nortriptyline | 1992 |
[Serum concentrations of amitriptyline and its metabolites and clinical effect in depressive patients].
Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nortriptyline | 1992 |
Pharmacokinetic analysis of amitriptyline and its demethylated metabolite in serum and brain of rats after acute and chronic oral administration of amitriptyline.
Topics: Administration, Oral; Amitriptyline; Animals; Brain; Chromatography, High Pressure Liquid; Injections, Intravenous; Male; Mathematics; Nortriptyline; Rats; Rats, Inbred Strains; Regression Analysis | 1992 |
Pharmacological comparison of the rat and guinea-pig cortical high affinity 5-hydroxytryptamine uptake system.
Topics: Amitriptyline; Animals; Binding, Competitive; Cerebral Cortex; Citalopram; Desipramine; Female; Guinea Pigs; Kinetics; Nortriptyline; Rats; Serotonin; Synaptosomes | 1992 |
Severe amitriptyline overdose: relationship between toxicokinetics and toxicodynamics.
Topics: Amitriptyline; Coma; Drug Overdose; Electrocardiography; Erythrocytes; Half-Life; Humans; Intubation; Nortriptyline; Ventilators, Mechanical | 1992 |
Amitriptyline and amitriptyline metabolites in blood and cerebrospinal fluid following human overdose.
Topics: Adult; Amitriptyline; Chromatography, High Pressure Liquid; Dialysis; Drug Overdose; Erythrocytes; Female; Half-Life; Humans; Male; Middle Aged; Nortriptyline; Sensitivity and Specificity | 1992 |
Inhibition and metabolite complexation of rat hepatic microsomal cytochrome P450 by tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Desipramine; Hydroxylation; Imipramine; Male; Microsomes, Liver; Nortriptyline; Rats; Rats, Inbred Strains; Steroid 16-alpha-Hydroxylase; Testosterone | 1992 |
Amitriptyline prevents N-methyl-D-aspartate (NMDA)-induced toxicity, does not prevent NMDA-induced elevations of extracellular glutamate, but augments kainate-induced elevations of glutamate.
Topics: Amitriptyline; Animals; Cell Death; Cells, Cultured; Extracellular Matrix; Glutamates; Imipramine; Kainic Acid; Lethal Dose 50; N-Methylaspartate; Neurons; Nortriptyline; Quisqualic Acid; Rats; Rats, Inbred Strains; Taurine | 1992 |
Effects of a secondary and a tertiary amine tricyclic antidepressant on cerebral biogenic amines as a function of mouse strain: a comparative neurotoxicological evaluation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amitriptyline; Animals; Biogenic Amines; Brain; Dopamine; Hydroxyindoleacetic Acid; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurotoxins; Nortriptyline; Organ Specificity; Serotonin; Species Specificity | 1991 |
Extremely long plasma half-life of amitriptyline in a woman with the cytochrome P450IID6 29/29-kilobase wild-type allele--a slowly reversible interaction with fluoxetine.
Topics: Alleles; Amitriptyline; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Depression; Drug Interactions; Female; Fluoxetine; Fluvoxamine; Half-Life; Humans; Middle Aged; Nortriptyline; Phenotype; Spectrophotometry, Ultraviolet | 1991 |
Stereoselective efflux of (E)-10-hydroxynortriptyline enantiomers from the cerebrospinal fluid of depressed patients.
Topics: Adult; Amitriptyline; Biological Transport, Active; Depressive Disorder; Female; Humans; Middle Aged; Nortriptyline; Protein Binding; Stereoisomerism; Ultrafiltration | 1991 |
Genotoxicity evaluation of five tricyclic antidepressants in the wing somatic mutation and recombination test in Drosophila melanogaster.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; DNA; Dose-Response Relationship, Drug; Drosophila melanogaster; Imipramine; Mutagenicity Tests; Nortriptyline; Protriptyline; Recombination, Genetic | 1991 |
Altered pharmacokinetics of tricyclic antidepressants in burns.
Topics: Adult; Amitriptyline; Burns; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Metabolic Clearance Rate; Nortriptyline; Serum Albumin; Suicide, Attempted | 1991 |
A comparison of three computer models for prediction of dose in acute amitriptyline overdose.
Topics: Amitriptyline; Animals; Chi-Square Distribution; Computer Simulation; Discriminant Analysis; Dogs; Dose-Response Relationship, Drug; Drug Overdose; Duodenum; Models, Biological; Nortriptyline; Probability; Software | 1991 |
Use of tricyclic antidepressants in recipients of heart transplants.
Topics: Adaptation, Psychological; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Heart Transplantation; Humans; Middle Aged; Nortriptyline; Postoperative Complications | 1991 |
Studies on the effects of antidepressant drugs on the antinociceptive action of morphine and on plasma morphine in rat and man.
Topics: Amitriptyline; Analgesia; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Drug Synergism; Humans; Morphine; Nortriptyline; Rats; Rats, Inbred Strains; Trazodone | 1990 |
The influence of ethanol on the distribution of amitriptyline and nortriptyline in rats.
Topics: Amitriptyline; Animals; Ethanol; Male; Nortriptyline; Rats; Rats, Inbred Strains; Tissue Distribution | 1990 |
[Therapeutic drug monitoring of tricyclic antidepressants].
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biological Availability; Chromatography, Gas; Chromatography, High Pressure Liquid; Desipramine; Humans; Immunoenzyme Techniques; Nortriptyline | 1990 |
Nonlinear kinetics of nortriptyline in every day practice.
Topics: Amitriptyline; Humans; Nortriptyline | 1990 |
Effects of amitriptyline and nortriptyline on cerebral activity of the CDF-1 mouse strain.
Topics: Amitriptyline; Animals; Cerebellum; Cerebral Cortex; Dopamine; Male; Mice; Motor Activity; Nortriptyline; Serotonin; Species Specificity | 1990 |
Association between dosage and serum concentration of antidepressants.
Topics: Adult; Aged; Aging; Amitriptyline; Antidepressive Agents; Biotransformation; Chromatography, High Pressure Liquid; Female; Humans; Male; Maprotiline; Middle Aged; Nortriptyline | 1990 |
Aspects of amitriptyline and nortriptyline plasma levels monitoring in depression.
Topics: Adult; Aged; Aging; Amitriptyline; Body Weight; Depressive Disorder; Female; Humans; Middle Aged; Monitoring, Physiologic; Nortriptyline; Psychiatric Status Rating Scales | 1990 |
Electrocardiographic effects of amitriptyline in therapeutic doses on 24-hr monitoring (Holter) with correlation to plasma levels.
Topics: Adult; Aged; Amitriptyline; Arrhythmias, Cardiac; Depressive Disorder; Electrocardiography, Ambulatory; Female; Humans; Male; Middle Aged; Nortriptyline | 1990 |
Pharmacokinetics of amitriptyline and its demethylated metabolite in serum and specific brain regions of rats after acute and chronic administration of amitriptyline.
Topics: Amitriptyline; Animals; Brain; Dealkylation; Injections, Intraperitoneal; Male; Nortriptyline; Rats; Rats, Inbred Strains; Solubility | 1990 |
The effect of nortriptyline-specific active immunization on amitriptyline toxicity and disposition in the rabbit.
Topics: Amitriptyline; Animals; Antibodies; Cross Reactions; Immunization; Injections, Intraperitoneal; Injections, Intravenous; Lethal Dose 50; Male; Neutralization Tests; Nortriptyline; Rabbits; Radioimmunoassay | 1990 |
Toxicological findings after fatal amitriptyline self-poisoning.
Topics: Adult; Amitriptyline; Humans; Male; Mass Spectrometry; Nortriptyline; Tissue Distribution | 1990 |
Radiologic correlates of antidepressant-induced delirium: the possible significance of basal-ganglia lesions.
Topics: Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Basal Ganglia; Basal Ganglia Diseases; Delirium; Depressive Disorder; Female; Fluoxetine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nortriptyline; Risk Factors; Trazodone | 1989 |
Tricyclic antidepressants and acid secretory response of rabbit gastric cells.
Topics: 1-Methyl-3-isobutylxanthine; Aminopyrine; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Bucladesine; Carbachol; Cyclic AMP; Gastric Acid; Gastric Mucosa; Histamine; Imipramine; Nortriptyline; Oxygen Consumption; Parietal Cells, Gastric; Rabbits; Receptors, Histamine; Time Factors | 1985 |
Amitriptyline: linear or nonlinear kinetics in every day practice?
Topics: Amitriptyline; Biotransformation; Depression; Humans; Linear Models; Nortriptyline | 1989 |
Evaluation of the EMIT amitriptyline and nortriptyline assays for the determination of serum clomipramine and desmethylclomipramine.
Topics: Amitriptyline; Antibody Specificity; Clomipramine; Cross Reactions; Evaluation Studies as Topic; Humans; Immunoenzyme Techniques; Indicators and Reagents; Nortriptyline | 1989 |
External quality assurance of tricyclic antidepressant measurements in serum: eight years of progress?
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Chromatography, High Pressure Liquid; Desipramine; Humans; Imipramine; Nortriptyline; Quality Control | 1989 |
Protective effect of flavonoids on drug-induced hepatotoxicity in vitro.
Topics: Alanine Transaminase; Amitriptyline; Animals; Animals, Newborn; Aspartate Aminotransferases; Catechin; Cells, Cultured; Erythromycin Estolate; Flavonoids; L-Lactate Dehydrogenase; Liver; Nortriptyline; Peroxides; Rats; Rats, Inbred Strains; Silymarin; tert-Butylhydroperoxide | 1989 |
Different cardiovascular effects of tricyclic antidepressants in the conscious and anesthetized rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cardiovascular System; Dose-Response Relationship, Drug; Hypotension; Male; Nortriptyline; Rats; Rats, Inbred Strains | 1989 |
Inhibition of 22Na influx by tricyclic and tetracyclic antidepressants and binding of [3H]imipramine in bovine adrenal medullary cells.
Topics: Adrenal Medulla; Amitriptyline; Animals; Anthracenes; Calcium; Carrier Proteins; Catecholamines; Cattle; Cells, Cultured; Imipramine; Kinetics; Maprotiline; Mianserin; Nortriptyline; Receptors, Drug; Receptors, Neurotransmitter; Sodium; Sodium Radioisotopes; Structure-Activity Relationship; Tritium | 1987 |
Automated determination of drugs in serum by column-switching high-performance liquid chromatography. IV. Separation of tricyclic and tetracyclic antidepressants and their metabolites.
Topics: Amitriptyline; Amoxapine; Antidepressive Agents; Antidepressive Agents, Tricyclic; Autoanalysis; Chromatography, High Pressure Liquid; Clomipramine; Humans; Hydrogen-Ion Concentration; Maprotiline; Nortriptyline; Quality Control; Regression Analysis | 1989 |
Antidepressants and EEG sleep: search for specificity.
Topics: Amitriptyline; Antidepressive Agents; Depressive Disorder; Desipramine; Humans; Nortriptyline; Sleep; Sleep Stages; Zimeldine | 1987 |
A role for serotonin and beta-endorphin in the analgesia induced by some tricyclic antidepressant drugs.
Topics: 5-Hydroxytryptophan; Amitriptyline; Analgesia; Animals; Antidepressive Agents, Tricyclic; beta-Endorphin; Clomipramine; Endorphins; Nortriptyline; Rats; Rats, Inbred Strains; Serotonin | 1987 |
Why is amitriptyline much weaker than desipramine at decreasing beta-adrenoceptor numbers?
Topics: Amitriptyline; Animals; Desipramine; In Vitro Techniques; Male; Norepinephrine; Nortriptyline; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1985 |
Results compared for tricyclic antidepressants as assayed by liquid chromatography and enzyme immunoassay.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Humans; Imipramine; Immunoenzyme Techniques; Nortriptyline | 1988 |
Valpromide increases the plasma concentrations of amitriptyline and its metabolite nortriptyline in depressive patients.
Topics: Adult; Amitriptyline; Anticonvulsants; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nortriptyline; Valproic Acid | 1988 |
Cerebrospinal fluid levels of amitriptyline, nortriptyline, imipramine and desmethylimipramine. Relationship to plasma levels and treatment outcome.
Topics: Amitriptyline; Bipolar Disorder; Depressive Disorder; Desipramine; Double-Blind Method; Female; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Male; Nortriptyline; Psychiatric Status Rating Scales | 1985 |
High-performance liquid chromatographic quantitation of amitriptyline and nortriptyline in dialysate from plasma or serum using on-line solid-phase extraction.
Topics: Amitriptyline; Chromatography, High Pressure Liquid; Dialysis; Humans; Nortriptyline | 1988 |
[Relation of plasma levels and clinical response to amitriptyline in treating endogenous depression].
Topics: Adult; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline | 1988 |
High levels of tricyclic antidepressants in conventional therapy: determinant factors.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Male; Maprotiline; Middle Aged; Nortriptyline; Risk Factors | 1988 |
Phenytoin prophylaxis of cardiotoxicity in experimental amitriptyline poisoning.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Dogs; Electrocardiography; Heart; Hypotension; Nortriptyline; Phenytoin; Tachycardia | 1988 |
Effects of drug-protein binding on trace enrichment of drugs in blood plasma on short precolumns.
Topics: Amitriptyline; Blood Proteins; Chemical Phenomena; Chemistry, Physical; Humans; Hydrogen-Ion Concentration; Naproxen; Nortriptyline; Pharmaceutical Preparations; Phosphoric Acids; Protein Binding; Serum Albumin | 1988 |
Lack of correlation between plasma levels of amitriptyline (and nortriptyline) and clinical improvement of chronic pain of peripheral neurologic origin.
Topics: Adult; Aged; Amitriptyline; Analgesics; Female; Humans; Male; Middle Aged; Nortriptyline; Pain; Pain Measurement | 1987 |
Quantitative homogeneous enzyme immunoassays for amitriptyline, nortriptyline, imipramine, and desipramine.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Cross Reactions; Desipramine; Humans; Imipramine; Immunoenzyme Techniques; Methods; Nortriptyline | 1986 |
Two tricyclic antidepressant poisonings: levels of amitriptyline, nortriptyline and desipramine in post-mortem biological samples.
Topics: Adult; Amitriptyline; Chromatography, High Pressure Liquid; Desipramine; Humans; Male; Nortriptyline; Suicide; Verapamil | 1987 |
Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin.
Topics: Adult; Amitriptyline; Debrisoquin; Depressive Disorder; Female; Humans; Hydantoins; Hydroxylation; Isoquinolines; Kinetics; Male; Mephenytoin; Middle Aged; Nortriptyline; Phenotype; Polymorphism, Genetic | 1986 |
Amitriptyline pharmacokinetics and clinical response: I. Free and total plasma amitriptyline and nortriptyline.
Topics: Adult; Amitriptyline; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Male; Middle Aged; Nortriptyline | 1986 |
New aspects in research on blood levels and bioavailability of antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Biological Availability; Debrisoquin; Depressive Disorder; Humans; Kinetics; Maprotiline; Mephenytoin; Nortriptyline | 1986 |
No interaction of diazepam on amitriptyline disposition in depressed patients.
Topics: Adult; Amitriptyline; Depressive Disorder; Diazepam; Drug Interactions; Female; Humans; Middle Aged; Nortriptyline; Spectrophotometry, Ultraviolet | 1987 |
Steady-state concentrations of amitriptyline and its metabolite nortriptyline in Saudi patients.
Topics: Amitriptyline; Humans; Kinetics; Nortriptyline; Saudi Arabia | 1987 |
Amitriptyline and nortriptyline plasma levels, urinary 3-methoxy-4-hydroxyphenylglycol and clinical response in depressed women.
Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Female; Glycols; Humans; Methoxyhydroxyphenylglycol; Middle Aged; Nortriptyline | 1986 |
Lack of interaction of ranitidine with amitriptyline.
Topics: Adult; Amitriptyline; Drug Interactions; Hemodynamics; Humans; Male; Nortriptyline; Psychomotor Performance; Ranitidine | 1987 |
[Reversed phase HPLC determination of amitriptyline and nortriptyline in plasma].
Topics: Amitriptyline; Chromatography, High Pressure Liquid; Humans; Nortriptyline | 1987 |
The effect of a lipid suspension on amitriptyline disposition.
Topics: Adult; Amitriptyline; Fat Emulsions, Intravenous; Female; Humans; Male; Nortriptyline; Triglycerides | 1987 |
Plasma-serum differences in the assessment of tricyclic antidepressant blood levels.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Humans; Imipramine; Nortriptyline; Plasma | 1987 |
Determination of amitriptylinoxide and its major metabolites amitriptyline and nortriptyline in plasma by high-performance liquid chromatography.
Topics: Amitriptyline; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Kinetics; Nortriptyline | 1986 |
[Relation of plasma amitriptyline and nortriptyline levels to the therapeutic response in endogenous depression].
Topics: Adolescent; Adult; Aged; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline | 1986 |
Amitriptyline metabolism: association with debrisoquin hydroxylation in nonsmokers.
Topics: Administration, Oral; Adult; Amitriptyline; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Mixed Function Oxygenases; Nortriptyline; Phenotype | 1986 |
Consistent reversal of abnormal DSTs after different antidepressant therapies in a patient with dementia.
Topics: Amitriptyline; Antidepressive Agents; Dementia; Depressive Disorder; Dexamethasone; Humans; Hydrocortisone; Imipramine; Male; Middle Aged; Nortriptyline; Trazodone | 1985 |
"Paradoxical" shortening of REM latency on first recording night in major depressive disorder: clinical and polysomnographic correlates.
Topics: Adaptation, Physiological; Adolescent; Adult; Aged; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales; Reaction Time; Sleep, REM | 1985 |
Tricyclic antidepressant and metabolite levels in chronic renal failure.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chromatography, Liquid; Depression; Desipramine; Female; Half-Life; Humans; Imipramine; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Nortriptyline; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis | 1985 |
Internight variability of REM latency in major depression: implications for the use of REM latency as a biological correlate.
Topics: Adult; Aged; Amitriptyline; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Electroencephalography; Female; Humans; Male; Middle Aged; Nortriptyline; Reaction Time; Sleep, REM | 1985 |
Interindividual differences in the binding of antidepressives to plasma proteins: the role of the variants of alpha 1-acid glycoprotein.
Topics: Adult; Amitriptyline; Antidepressive Agents; Blood Proteins; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; Orosomucoid; Polymorphism, Genetic; Protein Binding; Time Factors | 1985 |
Altered amitriptyline kinetics in a depressed patient with porto-caval anastomosis.
Topics: Administration, Oral; Adult; Amitriptyline; Depressive Disorder; Half-Life; Humans; Kinetics; Liver Cirrhosis, Alcoholic; Male; Nortriptyline; Portacaval Shunt, Surgical | 1985 |
Plasma levels of amitriptyline: effect of age and sex.
Topics: Adult; Age Factors; Aged; Amitriptyline; Depressive Disorder; Drug Administration Schedule; Female; Hospitalization; Humans; Kinetics; Male; Middle Aged; Nortriptyline; Sex Factors | 1985 |
Single oral dose pharmacokinetics of amitriptylinoxide and amitriptyline in humans.
Topics: Administration, Oral; Adult; Amitriptyline; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Nortriptyline | 1985 |
Analysis of tricyclic antidepressants in serum and plasma yields similar results.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Dealkylation; Humans; Nortriptyline | 1985 |
[Serum levels of amitriptyline and nortriptyline in a case of poisoning].
Topics: Adult; Amitriptyline; Female; Humans; Nortriptyline | 1985 |
Determination of compliance with riboflavin in an antidepressive therapy.
Topics: Adult; Amitriptyline; Creatinine; Depressive Disorder; Drug Combinations; Female; Half-Life; Humans; Male; Middle Aged; Nortriptyline; Patient Compliance; Riboflavin | 1985 |
Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Debrisoquin; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Hydroxylation; Isoquinolines; Lithium; Nortriptyline | 1985 |
The relationship between the lipophilic nature of tricyclic neuroleptics and antidepressants, and histamine release.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Chlorpromazine; Chlorprothixene; Clopenthixol; Desipramine; Fluphenazine; Histamine Release; Imipramine; Kinetics; Male; Mast Cells; Methotrimeprazine; Nortriptyline; Perphenazine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Rats; Solvents; Structure-Activity Relationship; Thioridazine; Tranquilizing Agents; Trifluoperazine | 1972 |
Plasma levels on antidepressants and clinical response.
Topics: Amitriptyline; Antidepressive Agents; Depression; Humans; Nortriptyline | 1973 |
Clinical significance of plasma levels of tricyclic antidepressant drugs in the treatment of depression.
Topics: Amitriptyline; Depression; Humans; Nortriptyline | 1973 |
Relief of postherpetic neuralgia with psychotropic drugs.
Topics: Aged; Amitriptyline; Analgesics; Antidepressive Agents; Antipsychotic Agents; Female; Fluphenazine; Herpesviridae Infections; Humans; Male; Middle Aged; Neuralgia; Nortriptyline; Pain; Perphenazine; Thioridazine | 1973 |
Metabolism of amitriptyline, nortriptyline, imipramine and desipramine to yield hydroxylamines.
Topics: Amitriptyline; Animals; Chromatography, Gas; Chromatography, Thin Layer; Desipramine; Guinea Pigs; Hydroxylamines; Imipramine; In Vitro Techniques; Mass Spectrometry; Microsomes, Liver; Mitochondria, Liver; Nortriptyline; Rabbits | 1973 |
Beta blockade in the treatment of tricyclic antidepressant overdosage.
Topics: Acetanilides; Adrenergic beta-Antagonists; Adult; Amino Alcohols; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Child, Preschool; Dibenzazepines; Electrocardiography; Female; Humans; Male; Nitrazepam; Nortriptyline | 1973 |
Identification of phenothiazine derivatives and analogs by x-ray diffraction. II. Active substances in pharmaceutical formulations.
Topics: Amitriptyline; Chlorprothixene; Crystallization; Dibenzazepines; Fluphenazine; Imipramine; Methods; Methotrimeprazine; Nortriptyline; Opipramol; Perphenazine; Phenothiazines; Picrates; Prochlorperazine; Promazine; Promethazine; Quaternary Ammonium Compounds; Thioridazine; Triflupromazine; X-Ray Diffraction | 1971 |
A new modification for studying 5-HT uptake by blood platelets: a re-evaluation of tricyclic antidepressants as uptake inhibitors.
Topics: Amitriptyline; Animals; Blood Platelets; Carbon Radioisotopes; Chlorpromazine; Desipramine; Dibenzazepines; Doxepin; Imipramine; In Vitro Techniques; Kinetics; Models, Biological; Nortriptyline; Promazine; Rabbits; Serotonin; Synaptosomes; Temperature; Trifluoperazine; Triflupromazine | 1974 |
Toxicology of some autopsy cases involving tricyclic antidepressant drugs.
Topics: Adult; Amitriptyline; Antidepressive Agents; Autopsy; Brain Chemistry; Desipramine; Dibenzazepines; Ethanol; Female; Humans; Imipramine; Kidney; Liver; Lung; Male; Middle Aged; Nortriptyline; Protein Binding; Spleen; Stomach | 1974 |
Antagonism of the hypotensive action of bethanidine and debrisoquine by tricyclic antidepressants.
Topics: Adult; Aged; Amidines; Amitriptyline; Antidepressive Agents; Antihypertensive Agents; Blood Pressure; Drug Antagonism; Female; Guanidines; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Quinolines | 1969 |
Overdose of tricyclic antidepressants and REM sleep rebound.
Topics: Amitriptyline; Antidepressive Agents; Dreams; Electroencephalography; Electromyography; Electrooculography; Humans; Imipramine; Nortriptyline; Sleep, REM; Time Factors | 1970 |
Systematic identification of psychotropic drugs by thin layer chromatography. II.
Topics: Amitriptyline; Chlorpromazine; Chlorprothixene; Chromatography, Thin Layer; Desipramine; Female; Humans; Imipramine; Male; Meprobamate; Nortriptyline; Phenothiazines; Schizophrenia; Silicon Dioxide; Thioridazine; Tranquilizing Agents | 1968 |
Overdose of tricyclic anti-depressants and deductions concerning their cerebral action.
Topics: Adolescent; Adult; Amitriptyline; Brain; Brain Chemistry; Dreams; Electroencephalography; Female; Humans; Imipramine; Neurons; Nortriptyline; Protein Biosynthesis; Sleep; Sleep, REM; Substance Withdrawal Syndrome | 1969 |
Influence of various substances which induce and inhibit aggregation on the uptake of deoxyglucose by human blood platelets.
Topics: Adenosine Diphosphate; Amitriptyline; Antidepressive Agents; Blood Glucose; Blood Platelets; Bucladesine; Carbon Radioisotopes; Chlorpromazine; Cyproheptadine; Desipramine; Epinephrine; Glucose; Humans; In Vitro Techniques; Norepinephrine; Nortriptyline; Platelet Adhesiveness; Promethazine; Serotonin; Thrombin | 1974 |
Lipid phase transitions and drug interactions.
Topics: Amitriptyline; Binding Sites; Calorimetry; Desipramine; Electron Spin Resonance Spectroscopy; Imipramine; Kinetics; Magnetic Resonance Spectroscopy; Membranes, Artificial; Models, Biological; Molecular Conformation; Morphinans; Morphine; Nortriptyline; Palmitic Acids; Phosphatidylcholines; Structure-Activity Relationship; Temperature; Thermodynamics | 1974 |
The effect of tricyclic antidepressive drugs on adrenaline and adenosine diphosphate induced platelet aggregation.
Topics: Adenine Nucleotides; Amitriptyline; Antidepressive Agents; Blood Platelets; Epinephrine; Imipramine; Nortriptyline | 1966 |
The intracerebral effects of noradrenaline and its modification by drugs in the mouse.
Topics: Amitriptyline; Animals; Antidepressive Agents; Ataxia; Atropine; Body Temperature; Brain; Central Nervous System; Chlordiazepoxide; Chlorpheniramine; Chlorpromazine; Diazepam; Drug Antagonism; Haloperidol; Histamine H1 Antagonists; Imipramine; Male; Mice; Norepinephrine; Nortriptyline; Pentobarbital; Phenytoin; Piperazines; Trihexyphenidyl | 1966 |
Effect of antidepressant and adrenergic blocking drugs on hyperthermia induced by reserpine.
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Body Temperature; Chlorisondamine; Chlorpromazine; Desipramine; Ethanolamines; Female; Fever; Hydrazines; Imipramine; Monoamine Oxidase Inhibitors; Norepinephrine; Nortriptyline; Phenoxybenzamine; Phentolamine; Propranolol; Rats; Reserpine; Sympatholytics; Tetrabenazine | 1967 |
[Aggressiveness of the rat following combined treatment with monomaime oxidase inhibitors and other psychotropic drugs, especially thymoleptics].
Topics: Aggression; Alkaloids; Amitriptyline; Amphetamine; Animals; Anthracenes; Body Temperature; Central Nervous System; Desipramine; Dibenzazepines; Dihydroxyphenylalanine; Humans; Hydrazines; Imipramine; Indoles; Iproniazid; Isocarboxazid; Male; Nortriptyline; Opipramol; Pargyline; Phenelzine; Rats; Stimulation, Chemical; Tranylcypromine | 1969 |
Effect of antidepressant drugs on accumulation and disappearance of monoamines formed in vivo from labelled precursors in mouse brain.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Carbon Isotopes; Desipramine; Dopamine; Imipramine; Male; Mice; Norepinephrine; Nortriptyline; Serotonin; Tritium; Tryptophan; Tyrosine | 1970 |
Modification by a tricyclic series of compounds of the noradrenaline effect on the cat nictitating membrane.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cats; Desipramine; Dibenzazepines; Drug Synergism; Imipramine; Nictitating Membrane; Norepinephrine; Nortriptyline | 1971 |
Behavioural effects od d-amphetamine alone and in combination with antidepressants, antihistamines or other psychotropic drugs in young chicks.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Chickens; Chlorpheniramine; Cocaine; Desipramine; Dextroamphetamine; Diphenhydramine; Drug Antagonism; Drug Interactions; Histamine H1 Antagonists; Imipramine; Male; Nortriptyline; Promethazine | 1972 |
Effect of dimethyl and monomethyl tricyclic antidepressants on central 5-hydroxytryptamine processes in the frog.
Topics: Amitriptyline; Animals; Antidepressive Agents; Anura; Brain; Desipramine; Dibenzazepines; Imipramine; Male; Muscle Contraction; Nortriptyline; Rana temporaria; Serotonin | 1971 |
Central hemodynamics in severe poisoning by hypnotic drugs. Coma depth and body temperature.
Topics: Adult; Aged; Amitriptyline; Blood Pressure; Body Temperature; Cardiac Output; Central Venous Pressure; Chlorpromazine; Chlorprothixene; Coma; Dibenzazepines; Female; Glutethimide; Heart Rate; Hemodynamics; Humans; Hypnotics and Sedatives; Male; Middle Aged; Nortriptyline; Oxygen Consumption; Pentobarbital; Phenothiazines; Tranquilizing Agents; Vascular Resistance | 1972 |
Poisoning as a complication of enuresis.
Topics: Amitriptyline; Antidepressive Agents; Child, Preschool; Enuresis; Humans; Imipramine; Ipecac; Nortriptyline; Seizures; Tachycardia | 1972 |
[Tricyclic anti-depressant drugs and dopamine sensitive adenylcyclase from rat caudate nuclei].
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amitriptyline; Animals; Antidepressive Agents; Basal Metabolism; Caudate Nucleus; Chlorpromazine; Desipramine; Dopamine; Imipramine; Nortriptyline; Rats; Stimulation, Chemical | 1974 |
Antidepressant agents. II. Thiophene analogues of amitriptyline and nortriptyline.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cerebral Cortex; Chemical Phenomena; Chemistry; Cocaine; Depression, Chemical; Drug Evaluation, Preclinical; Hydrocarbons, Chlorinated; Hypothermia; Male; Methods; Mice; Norepinephrine; Nortriptyline; Reserpine; Serotonin; Thiophenes; Tritium | 1974 |
Relationships between tricyclic antidepressant concentrations, 1-3H-noradrenaline uptake and chronotropic effect in isolated rat atria.
Topics: Amitriptyline; Animals; Antidepressive Agents; Carbon Radioisotopes; Chromatography, Thin Layer; Clomipramine; Dealkylation; Desipramine; Dose-Response Relationship, Drug; Doxepin; Drug Synergism; Female; Heart Atria; Heart Rate; Norepinephrine; Nortriptyline; Rats; Rats, Inbred Strains; Stimulation, Chemical; Time Factors; Tritium | 1974 |
Confusional states in elderly mental patients treated with antidepressants.
Topics: Aged; Amitriptyline; Cognition Disorders; Confusion; Depression; Drug Therapy, Combination; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Tranquilizing Agents | 1974 |
Steady-state plasma concentrations during single and multiple dosage schedules of amitriptyline.
Topics: Administration, Oral; Adult; Amitriptyline; Humans; Male; Nortriptyline; Time Factors | 1974 |
Cardiovascular effects of amitriptyline, nortriptyline, protriptyline and doxepin in conscious rabbits.
Topics: Amitriptyline; Animals; Antidepressive Agents; Aorta; Blood Pressure; Depression, Chemical; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Doxepin; Drug Synergism; Electrocardiography; Heart Atria; Heart Rate; Hemodynamics; Muscle Contraction; Muscle, Smooth; Norepinephrine; Nortriptyline; Propylamines; Rabbits | 1974 |
Combined thyroid (triiodothyronine)-tricyclic antidepressant treatment in depressive states.
Topics: Adjustment Disorders; Adult; Amitriptyline; Antidepressive Agents; Anxiety; Bipolar Disorder; Blood Pressure; Depression; Desipramine; Drug Therapy, Combination; Female; Humans; Imipramine; Male; Middle Aged; Motor Activity; Nortriptyline; Pulse; Time Factors; Triiodothyronine; Verbal Behavior | 1974 |
A thin-layer method for the determination of amitriptyline and nortriptyline in plasma.
Topics: Amitriptyline; Chromatography, Thin Layer; Densitometry; Ethanol; Hot Temperature; Humans; Hydrochloric Acid; Nortriptyline; Spectrometry, Fluorescence; Time Factors | 1974 |
Distribution of amitriptyline and nortriptyline in fatal amitriptyline intoxications with different survival times.
Topics: Adult; Amitriptyline; Brain Chemistry; Chromatography, Gas; Female; Forensic Medicine; Humans; Kidney; Liver; Lung; Male; Myocardium; Nortriptyline; Time Factors | 1974 |
Correlation of the cardiotoxicity of tricyclic antidepressants to their membrane effects.
Topics: Amitriptyline; Anesthesia, Local; Animals; Cell Membrane; Cornea; Depression, Chemical; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Doxepin; Electrocardiography; Erythrocytes; Heart Rate; Hemolysis; Male; Mice; Nortriptyline; Octanols; Propylamines; Rabbits; Stimulation, Chemical; Surface Tension | 1974 |
Structure-activity relations for the inhibition of 5-hydroxytryptamine uptake by tricyclic antidepressants into synaptosomes from serotoninergic neurones in rat brain homogenates.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain Chemistry; Chlorpromazine; Hypothalamus; Imipramine; In Vitro Techniques; Iprindole; Methylation; Neurons; Nortriptyline; Promazine; Rats; Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Synaptosomes | 1974 |
L-dopa and tricyclic antidepressants in affective disorders. A pilot study.
Topics: Adult; Amitriptyline; Depression; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Nausea; Nortriptyline; Pilot Projects; Vomiting | 1974 |
[Differentiation of secondary and tertiary tricyclic antidepressants in frogs].
Topics: Amitriptyline; Animals; Antidepressive Agents; Anura; Imipramine; Male; Nortriptyline; Phenelzine; Rana temporaria; Reserpine | 1972 |
Incorporation of imipramine into isolated rat peritoneal mast cells in vitro.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Binding Sites; Calcium; Cell Membrane Permeability; Chlorpromazine; Cocaine; Depression, Chemical; Desipramine; Dibenzazepines; Female; Guanethidine; Hydrogen-Ion Concentration; Imipramine; Leukocytes; Male; Mast Cells; Nortriptyline; Rats; Receptors, Drug; Reserpine; Serotonin; Temperature | 1974 |
Cardiovascular effects of poisoning with tricyclic antidepressants.
Topics: Adult; Amitriptyline; Blood; Blood Pressure; Body Temperature; Carbon Dioxide; Cardiac Output; Coma; Depression, Chemical; Electrocardiography; Female; Heart Rate; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Nortriptyline; Oxygen; Oxygen Consumption; Partial Pressure; Positive-Pressure Respiration; Propranolol; Stimulation, Chemical; Suicide; Time Factors | 1974 |
Functional group contribution in ion-pair extraction of tricyclic amines.
Topics: Amitriptyline; Bromides; Chemical Phenomena; Chemistry; Chlorates; Chlorides; Desipramine; Imipramine; Iodides; Ions; Mathematics; Naphthalenes; Nitrates; Nortriptyline; Spectrophotometry, Ultraviolet; Tosyl Compounds | 1972 |
Proceedings: Effect of tricyclic antidepressants on drug metabolism.
Topics: Adult; Amitriptyline; Animals; Antidepressive Agents; Antipyrine; Desipramine; Dibenzazepines; Female; Half-Life; Hexobarbital; Humans; Imipramine; Liver; Male; Nortriptyline; Rats | 1972 |
Relationship between substances strengthening of the thrombocyte cell membrane on the aggregation of thrombocytes and on the uptake and release of serotonin.
Topics: Adenosine Diphosphate; Amitriptyline; Benzothiepins; Blood Platelets; Cell Membrane; Cell Membrane Permeability; Chlorpromazine; Colorimetry; Desipramine; Epinephrine; Humans; Imipramine; In Vitro Techniques; Nortriptyline; Phentolamine; Piperazines; Platelet Adhesiveness; Propranolol; Receptors, Adrenergic; Serotonin; Serotonin Antagonists; Spectrometry, Fluorescence; Tranquilizing Agents | 1972 |
Binding of cyproheptadine-(N-methyl- 14 C) by human blood platelets: inhibition by phenothiazines and tricyclic antidepressants.
Topics: Amitriptyline; Blood Platelets; Carbon Isotopes; Centrifugation; Chlorpromazine; Cyproheptadine; Desipramine; Humans; Imipramine; In Vitro Techniques; Nortriptyline; Phenothiazines; Platelet Adhesiveness; Promethazine | 1973 |
Benzodiazepines and tricyclic antidepressant plasma levels.
Topics: Amitriptyline; Benzazepines; Chlordiazepoxide; Diazepam; Drug Combinations; Drug Interactions; Female; Humans; Male; Nitrazepam; Nortriptyline; Oxazepam; Tranquilizing Agents | 1973 |
Studies on the disposition of amitriptyline and other tricyclic antidepressant drugs in man as it relates to the management of the overdosed patient.
Topics: Adult; Amitriptyline; Antidepressive Agents; Charcoal; Chromatography, Gas; Desipramine; Female; Gastric Juice; Humans; Imipramine; Male; Mass Spectrometry; Nortriptyline; Poisoning | 1973 |
Permeability changes in the blood-brain barrier induced by nortriptyline and chlorpromazine.
Topics: Amitriptyline; Animals; Autoradiography; Blood-Brain Barrier; Brain; Capillaries; Carbon Radioisotopes; Cell Membrane Permeability; Cerebral Cortex; Chlorpromazine; Desipramine; Diphenhydramine; Dopamine; Imipramine; In Vitro Techniques; Inulin; Male; Mannitol; Molecular Weight; Nortriptyline; Rats; Tritium | 1973 |
The use of sodium bicarbonate in the treatment of tricyclic antidepressant-induced arrhythmias.
Topics: Acid-Base Equilibrium; Acidosis; Amitriptyline; Animals; Antidepressive Agents; Arrhythmias, Cardiac; Bicarbonates; Blood Proteins; Carbon Dioxide; Child, Preschool; Dibenzazepines; Dogs; Female; Humans; Hydrogen-Ion Concentration; Imipramine; Infant; Male; Nortriptyline; Protein Binding; Respiration, Artificial | 1973 |
[Fatal limbratil-F intoxication with post mortem gas chromatographic demonstration of tissue levels of amitriptyline and nortriptyline (author's transl)].
Topics: Adjustment Disorders; Adult; Amitriptyline; Brain Chemistry; Chlordiazepoxide; Chromatography, Gas; Drug Combinations; Electrocardiography; Female; Heart Arrest; Humans; Liver; Methods; Myocardium; Nortriptyline; Resuscitation; Suicide | 1973 |
[Evaluation of central antireserpine effect by the use of light blink reflex (author's transl)].
Topics: Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Chlorpromazine; Chlorprothixene; Desipramine; Dibenzazepines; Dibenzocycloheptenes; Diethylamines; Dimethylamines; Ethylenediamines; Glycolates; Imipramine; Light; Nortriptyline; Propylamines; Rabbits; Reflex; Reserpine | 1973 |
Stimulation of drug metabolism in man by tricyclic antidepressants.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adult; Amitriptyline; Amobarbital; Analysis of Variance; Antidepressive Agents; Antipyrine; Desipramine; Dibenzazepines; Female; Half-Life; Humans; Hydrocortisone; Hydroxycorticosteroids; Imipramine; Male; Nortriptyline; Stimulation, Chemical; Time Factors | 1973 |
Qualitative and quantitative studies on the disposition of amitriptyline and other tricyclic antidepressant drugs in man as it relates to the management of the overdosed patient.
Topics: Absorption; Adult; Aged; Amitriptyline; Antidepressive Agents; Bile; Body Fluids; Charcoal; Chromatography, Gas; Female; Gastric Juice; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Suicide | 1973 |
The distribution pattern of a series of tricyclic and bicyclic thymoleptics compared with their lipophilic properties and binding to plasma proteins.
Topics: Amines; Amitriptyline; Animals; Anthracenes; Benzofurans; Blood Proteins; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Chromatography, Thin Layer; Lung; Male; Nortriptyline; Paraffin; Protein Binding; Rats; Time Factors; Tranquilizing Agents | 1973 |
GLC method for quantitative determination of amitriptyline in human plasma.
Topics: Amitriptyline; Chromatography, Gas; Humans; Methods; Nortriptyline; Time Factors | 1974 |
The simultaneous determination of amitriptyline and nortriptyline in post mortem blood and urine using gas-liquid chromatography.
Topics: Amitriptyline; Chromatography, Gas; Forensic Medicine; Humans; Methods; Nortriptyline | 1974 |
Comparison of tricyclic antidepressants in rabbits: antinociception and potentiation of the noradrenaline pressor responses.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Aorta; Blood Pressure; Chlorpromazine; Desipramine; Dibenzazepines; Dose-Response Relationship, Drug; Doxepin; Drug Synergism; Imipramine; In Vitro Techniques; Iprindole; Lithium; Morphine; Norepinephrine; Nortriptyline; Opipramol; Rabbits; Succinimides; Time Factors | 1974 |
5-Hydroxytryptamine in depression.
Topics: Aged; Amitriptyline; Antidepressive Agents; Biogenic Amines; Blood Platelets; Depression; Dibenzazepines; Genetics; Humans; Middle Aged; Monoamine Oxidase Inhibitors; Nortriptyline; Serotonin | 1974 |
Blockade by triptyline compounds of tyramine uptake and of tyramine-induced phosphorylase activation in cardiac tissue.
Topics: Amitriptyline; Animals; Antidepressive Agents; Epinephrine; Female; Glucosyltransferases; Myocardium; Nortriptyline; Octopamine; Rats; Tritium; Tyramine | 1969 |
Fluorimetric determinations by ion pair extraction. 3. Extraction constants of ion pairs between anthracene-2-sulphonate and mono- and divalent amines.
Topics: Amines; Amitriptyline; Anthracenes; Desipramine; Dibenzazepines; Emetine; Hydrocarbons, Halogenated; Imipramine; Ions; Nortriptyline; Prenylamine; Spectrometry, Fluorescence; Sulfonic Acids | 1972 |
[Neuropsychiatric aspects of male sterility].
Topics: Amitriptyline; Depression; Dibenzazepines; Frustration; Humans; Imipramine; Infertility, Male; Male; Monoamine Oxidase Inhibitors; Neurotic Disorders; Nortriptyline; Personality Disorders | 1972 |
Toxic interactions of d-amphetamine and tricyclic antidepressants in mice.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Dextroamphetamine; Drug Antagonism; Drug Interactions; Drug Synergism; Imipramine; Injections, Intraperitoneal; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Nortriptyline; Promazine; Time Factors | 1972 |
Interaction between digoxin and tricyclic antidepressants in the rat.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Digoxin; Dose-Response Relationship, Drug; Drug Interactions; Heart; Heart Arrest; Imipramine; Male; Nortriptyline; Rats; Reserpine; Stress, Physiological | 1972 |
Overdosage of tricyclic antidepressants. A report of two deaths and a prospective study of 24 patients.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Bundle-Branch Block; Electrocardiography; Female; Fever of Unknown Origin; Heart Block; Heart Conduction System; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Prospective Studies; Psychoses, Substance-Induced; Seizures | 1972 |
Binding and oxidation of amitriptyline and a series of its oxidized metabolites in liver microsomes from untreated and phenobarbital-treated rats.
Topics: Amitriptyline; Animals; Chromatography, Gas; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Male; Mass Spectrometry; Methylation; Microsomes, Liver; Nortriptyline; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Spectrophotometry; Stimulation, Chemical; Structure-Activity Relationship; Time Factors | 1972 |
Influence of a chronic treatment on the distribution of amitryptiline and metabolites in rabbit brain.
Topics: Amitriptyline; Analysis of Variance; Animals; Brain; Brain Stem; Cell Membrane Permeability; Cerebellum; Diencephalon; Hydroxylation; Kidney; Liver; Male; Nortriptyline; Rabbits | 1971 |
Gas chromatography-mass spectrometry in forensic chemistry for identification of substances isolated from tissue.
Topics: Amitriptyline; Chromatography, Gas; Forensic Medicine; Mass Spectrometry; Meperidine; Methaqualone; Nortriptyline; Orphenadrine; Phenethylamines; Spectrum Analysis | 1971 |
A specific gas-chromatographic method for the measurement of "steady-state" plasma levels of amitriptyline and nortriptyline in patients.
Topics: Administration, Oral; Amitriptyline; Carbon Isotopes; Chromatography, Gas; Humans; Mental Disorders; Methods; Nortriptyline; Tritium | 1971 |
Metabolism of propranolol by rat liver microsomes and its inhibition by phenothiazine and tricyclic antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Desipramine; Imipramine; Kinetics; Liver; Male; Metabolism; Microsomes, Liver; NAD; NADP; Nitrogen; Nortriptyline; Perphenazine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Propranolol; Rats; Subcellular Fractions; Trifluoperazine; Triflupromazine | 1971 |
[Changes in tonus of the bladder and its sphincter under thymoleptic treatment. Cystomanometric measurements in man].
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Carbachol; Desipramine; Dibenzazepines; Enuresis; Humans; Imipramine; Manometry; Middle Aged; Muscle Tonus; Nortriptyline; Pressure; Urinary Bladder; Water-Electrolyte Balance | 1971 |
Physostigmine therapy in acute tricyclic antidepressant poisoning.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Barbiturates; Blood Pressure; Child, Preschool; Female; Heart Rate; Humans; Nortriptyline; Physostigmine; Poisoning; Tachycardia; Time Factors | 1971 |
Tricyclic antidepressants and heart disease.
Topics: Amitriptyline; Antidepressive Agents; Heart Diseases; Humans; Nortriptyline | 1971 |
Effect of some drugs on the uptake of monoamines and their precursors in the mouse Paneth cells.
Topics: 5-Hydroxytryptophan; Amines; Amitriptyline; Amphetamine; Animals; Binding Sites; Catecholamines; Chlorpromazine; Cocaine; Colon; Cytoplasmic Granules; Decarboxylation; Dihydroxyphenylalanine; Dopamine; Duodenum; Female; Guanethidine; Ileum; Imipramine; Jejunum; Male; Methyltyrosines; Mice; Microscopy, Fluorescence; Nortriptyline; Pargyline; Peptide Biosynthesis; Promazine; Reserpine; Serotonin; Tyrosine | 1971 |
Plasma protein binding of tricyclic anti-depressants in man.
Topics: Amitriptyline; Antidepressive Agents; Blood Proteins; Carbon Isotopes; Desipramine; Humans; Imipramine; Nortriptyline; Phenytoin; Protein Binding; Temperature; Tritium | 1969 |
Studies of the influence of some psychotropic substances on the grooming behaviour of white mice.
Topics: Amitriptyline; Animals; Aspirin; Charcoal; Chlordiazepoxide; Chlorpromazine; Desipramine; Dextroamphetamine; Female; Grooming; Haloperidol; Imipramine; Iproniazid; Metronidazole; Mice; Nortriptyline; Psychopharmacology | 1969 |
Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antimetabolites; Brain; Cocaine; Desipramine; Imipramine; In Vitro Techniques; Mice; Nortriptyline; Reserpine; Serotonin; Tritium; Tryptamines | 1969 |
Effects of tricyclic antidepressants on the uptake and mabolism of intracisternally administered norepinephrine-H3 in rat brain.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Brain Chemistry; Cell Membrane; Cerebral Ventricles; Desipramine; Imipramine; Injections; Injections, Intraperitoneal; Male; Mitochondria; Norepinephrine; Normetanephrine; Nortriptyline; Rats; Tritium | 1969 |
Use of antidepressant drugs during the first trimester.
Topics: Amitriptyline; Desipramine; Embryo, Mammalian; Female; Gestational Age; Humans; Imipramine; Nortriptyline; Pregnancy | 1969 |
[A possible mechanism of disaggregation of ADP-induced aggregates by imipramin and structurally related compouds].
Topics: Adenine Nucleotides; Amitriptyline; Blood Platelets; Chlorpromazine; Desipramine; Diphenhydramine; Humans; Imipramine; Nortriptyline; Optical Rotatory Dispersion; Platelet Adhesiveness; Promazine; Promethazine | 1969 |
[Cardiodepressive and local anesthetic effect of thymoleptics. Comparative studies with imipramine, desipramine, amitriptyline, nortriptyline and melitracene].
Topics: Amitriptyline; Anesthetics, Local; Animals; Anthracenes; Cornea; Depression, Chemical; Desipramine; Drug Synergism; Guinea Pigs; Heart Rate; Imipramine; In Vitro Techniques; Norepinephrine; Nortriptyline; Rabbits; Time Factors; Tyramine | 1969 |
Fatal amitriptytine poisoning. Determination of the drug in forensic-chemical material.
Topics: Adult; Amitriptyline; Depression; Female; Forensic Medicine; Humans; Liver; Nortriptyline; Spectrophotometry; Stomach; Suicide | 1969 |
[Thymoleptics and lipolysis].
Topics: Adipose Tissue; Amitriptyline; Animals; Antidepressive Agents; Cocaine; Depression, Chemical; Desipramine; Dibenzazepines; Fatty Acids, Nonesterified; Imipramine; In Vitro Techniques; Lipid Metabolism; Male; Norepinephrine; Nortriptyline; Photometry; Rats; Stimulation, Chemical; Tranquilizing Agents | 1969 |
Persistent extrapyramidal oral dyskinesias following treatment with thymoleptics.
Topics: Aged; Amitriptyline; Antidepressive Agents; Depressive Disorder, Major; Facial Muscles; Female; Humans; Imipramine; Lip; Middle Aged; Movement Disorders; Nortriptyline; Tongue | 1970 |
[Current problems of endogenous depression].
Topics: Amitriptyline; Antidepressive Agents; Chlorpromazine; Convulsive Therapy; Depression; Desipramine; Fluphenazine; Humans; Imipramine; Methotrimeprazine; Nortriptyline; Perphenazine; Thioridazine | 1970 |
[Clinical antidepressant drug therapy].
Topics: Amitriptyline; Antidepressive Agents; Depression; Desipramine; Dibenzazepines; Humans; Imipramine; Nortriptyline; Prognosis | 1970 |
[10 years of therapeutic experience using thioxanthene derivates].
Topics: Amitriptyline; Chlorprothixene; Clopenthixol; Humans; Neurotic Disorders; Nortriptyline; Psychotic Disorders; Tranquilizing Agents; Xanthenes | 1970 |
Studies on interactions involving antidepressive and other drugs with tetrabenazine and noradnamine on locomotor activity in mice, including details of the experimental design and statistical analysis.
Topics: Amitriptyline; Analysis of Variance; Animals; Atropine; Bretylium Compounds; Chlorpromazine; Cycloheptanes; Depression, Chemical; Dextroamphetamine; Dibenzocycloheptenes; Drug Antagonism; Ketones; Male; Mice; Motor Activity; Nialamide; Nortriptyline; Phentolamine; Tetrabenazine | 1970 |
A report on autopsy cases involving amitriptyline and nortriptyline.
Topics: Adolescent; Adult; Aged; Amitriptyline; Autopsy; Child; Humans; Infant; Kidney; Liver; Male; Middle Aged; Nortriptyline | 1970 |
Noveril (dibenzepin)--another new antidepressive.
Topics: Amitriptyline; Antidepressive Agents; Depression; Dibenzazepines; Humans; Imipramine; Nortriptyline | 1970 |
Antianxiety and anti-depressant drugs.
Topics: Amitriptyline; Antidepressive Agents; Anxiety; Chlordiazepoxide; Depression; Desipramine; Dibenzoxepins; Humans; Imipramine; Nortriptyline; Tranquilizing Agents | 1970 |
[Pharmacological studies of a new antidepressant nortriptyline (Noritren)].
Topics: Amitriptyline; Animals; Behavior, Animal; Body Temperature; Brain Chemistry; Cats; Chlorpromazine; Conditioning, Classical; Electroencephalography; Haloperidol; Imipramine; Mice; Norepinephrine; Nortriptyline; Perphenazine; Rats; Reserpine; Serotonin; Sleep | 1970 |
[Complications caused by anonymous preclinical medication].
Topics: Amitriptyline; Antidepressive Agents; Barbiturates; Bromides; Cannabis; Chlordiazepoxide; Delirium; Depression; Female; Hallucinogens; Haloperidol; Humans; Imipramine; Lysergic Acid Diethylamide; Male; Nortriptyline; Phenacetin; Self Medication; Substance-Related Disorders | 1970 |
[Tests on the analgetic effect of dextropropoxyphene combined with psychotropic drugs in the mouse].
Topics: Amitriptyline; Analgesia; Analgesics; Animals; Antidepressive Agents; Chlorpromazine; Chlorprothixene; Clopenthixol; Dextropropoxyphene; Drug Synergism; Methods; Mice; Nortriptyline; Reflex; Stimulation, Chemical; Tranquilizing Agents | 1970 |
[Animal experiments to study the cardiotoxic effect of thymoleptics].
Topics: Amitriptyline; Animals; Blood Pressure; Cats; Desipramine; Drug Synergism; Epinephrine; Heart; Heart Failure; Humans; Imipramine; Nortriptyline; Tranquilizing Agents | 1971 |
Tricyclic antidepressants and monoamine oxidase inhibitors.
Topics: Administration, Oral; Adolescent; Adult; Aged; Amitriptyline; Animals; Depression; Desipramine; Drug Synergism; Female; Fever; Humans; Hypertension; Hypotension; Imipramine; Isocarboxazid; Male; Middle Aged; Monoamine Oxidase Inhibitors; Nortriptyline; Phenelzine; Seizures | 1971 |
Comparative study of imipramine, amitriptyline and their desmethyl analogues in the hypothyroid rat.
Topics: Amitriptyline; Animals; Blepharoptosis; Desipramine; Exploratory Behavior; Female; Hypothyroidism; Imipramine; Motor Activity; Nortriptyline; Posture; Propylthiouracil; Psychopharmacology; Rats; Sympathomimetics; Tetrabenazine | 1967 |
Mechanism of inhibition of experimental inflammation by antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents; Carrageenan; Catecholamines; Desipramine; Dextrans; Drug Synergism; Edema; Female; Formaldehyde; Imipramine; Nortriptyline; Rats | 1967 |
[On the management of pain using antidepressive agents].
Topics: Amitriptyline; Antidepressive Agents; Desipramine; Humans; Imipramine; Nortriptyline; Pain | 1967 |
[Nortriptyline poisoning].
Topics: Adult; Amitriptyline; Desipramine; Female; Humans; Imipramine; Nortriptyline | 1967 |
The use of psychoactive drugs in the outpatient treatment of psychiatric disorders of children.
Topics: Adolescent; Amitriptyline; Child; Child Behavior Disorders; Child, Preschool; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Female; Humans; Male; Nortriptyline; Outpatient Clinics, Hospital; Parent-Child Relations; Phenothiazines; Physician-Patient Relations; Psychopharmacology; Psychotherapy | 1968 |
Tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Desipramine; Dibenzazepines; Enuresis; Humans; Imipramine; Nortriptyline; Opipramol | 1968 |
Myocardial damage in amitriptyline and nortriptyline poisoning.
Topics: Adult; Alanine Transaminase; Amitriptyline; Aspartate Aminotransferases; Cardiomyopathies; Electrocardiography; Humans; Hydroxybutyrate Dehydrogenase; Male; Middle Aged; Necrosis; Nortriptyline | 1968 |
Studies of the influence of some psychotropic substances on the grooming behaviour of white mice.
Topics: Amitriptyline; Animals; Aspirin; Charcoal; Chlordiazepoxide; Chlorpromazine; Desipramine; Dextroamphetamine; Grooming; Haloperidol; Imipramine; Iproniazid; Metronidazole; Mice; Nortriptyline; Sodium Chloride; Solvents; Tranquilizing Agents | 1968 |
Potentiation of 5-hydroxytryptamine release from platelets by desmethylation of chlorpromazine and related agents.
Topics: Amitriptyline; Animals; Blood Platelets; Chlorpromazine; Drug Synergism; Imipramine; Methylation; Nortriptyline; Rabbits; Serotonin | 1968 |
[On the analgesic affect of thymoleptics].
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Codeine; Desipramine; Dibenzazepines; Humans; Imipramine; Male; Mice; Nortriptyline; Phosphates; Quinones; Tranquilizing Agents | 1968 |
[Investigation of gastric ulcer inhibiting and secreto-inhibitory actions of thymoleptics in rats].
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Gastric Juice; Imipramine; Nortriptyline; Rats; Stomach Ulcer | 1968 |
The effect of antidepressants and "tranquilizers" on the response of mice to ethanol.
Topics: Accidents, Traffic; Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Coma; Desipramine; Diazepam; Dibenzazepines; Drug Synergism; Ethanol; Humans; Imipramine; Methylphenidate; Mice; Nortriptyline; Phenelzine; Phenobarbital; Reflex; Substance-Related Disorders; Thioridazine; Tranquilizing Agents; Trifluoperazine | 1968 |
Masked depression and the use of antidepressants in general practice.
Topics: Adult; Age Factors; Amitriptyline; Antidepressive Agents; Depression; Family Practice; Female; Humans; Imipramine; Iproniazid; Male; Middle Aged; Nortriptyline; Phenelzine; Retrospective Studies; Sex Factors; Tranylcypromine | 1969 |
Molecular features affecting the potency of tricyclic antidepressants and structurally related compounds as inhibitors of the uptake of tritiated norepinephrine by rabbit aortic strips.
Topics: Amitriptyline; Animals; Antidepressive Agents; Aorta; Benzazepines; Carbazoles; Chemical Phenomena; Chemistry; Dibenzocycloheptenes; Imipramine; In Vitro Techniques; Kinetics; Models, Chemical; Norepinephrine; Nortriptyline; Rabbits; Stereoisomerism | 1969 |
Dibenz[c,d,h]azulenes. II. "Bridged" amitriptyline analogs.
Topics: Amitriptyline; Amphetamine; Animals; Biological Assay; Body Temperature; Central Nervous System; Chemical Phenomena; Chemistry; Hexobarbital; Hypothermia, Induced; Mice; Nortriptyline; Reserpine; Sympathetic Nervous System; Sympathomimetics; Terpenes | 1969 |
Cardiac abnormalities in poisoning with tricyclic antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Desipramine; Electrocardiography; Female; Heart; Humans; Imipramine; Nortriptyline | 1969 |
Extrinsic factors influencing responses to psychotherapeutic drugs.
Topics: Adult; Amitriptyline; Analysis of Variance; Black or African American; Chlorpromazine; Depression; Diazepam; Hospitalization; Humans; Nortriptyline; Perphenazine; Phenothiazines; Prognosis; Psychiatric Status Rating Scales; Schizophrenia; Socioeconomic Factors; Sulfonamides | 1969 |
Concentrations of amitriptyline and its metabolites in urine, blood and tissue in fatal amitriptyline poisoning.
Topics: Adult; Amitriptyline; Chromatography, Thin Layer; Female; Humans; Liver; Male; Methods; Middle Aged; Nortriptyline; Spectrophotometry | 1969 |
Decreased turnover in central 5-HT nerve terminals induced by antidepressant drugs of the imipramine type.
Topics: Amitriptyline; Animals; Brain; Brain Chemistry; Dibenzazepines; Fluorescence; Male; Nerve Endings; Nortriptyline; Rats; Serotonin; Tryptophan Oxygenase | 1969 |
Desipramine.
Topics: Amitriptyline; Depression; Desipramine; Humans; Nortriptyline | 1965 |
[Clinical experiences with nortriptyline].
Topics: Adult; Aged; Amitriptyline; Bipolar Disorder; Depression; Female; Humans; Male; Middle Aged; Nortriptyline | 1965 |
A comparison of nortriptyline and amitriptyline in depression.
Topics: Amitriptyline; Antidepressive Agents; Depression; Female; Humans; Male; Nortriptyline | 1965 |
Effect of electroshock and antidepressant drugs on cerebrovascular permeability to cocaine in the rat.
Topics: Amitriptyline; Animals; Antidepressive Agents; Blood-Brain Barrier; Chlorpromazine; Cocaine; Electric Stimulation; Electroshock; Female; Imipramine; Injections, Intravenous; Nortriptyline; Rats | 1966 |
[Effects of dibenzocycloheptadienic derivatives in treatment of depressive syndromes].
Topics: Amitriptyline; Anxiety Disorders; Depression; Humans; Nortriptyline; Schizophrenia | 1966 |
Poisoning by amitriptyline, imipramine and nortriptyline.
Topics: Amitriptyline; Animals; Antidepressive Agents; Humans; Imipramine; Mice; Nortriptyline | 1966 |
[Comparative clinical experiences with Protriptyline in depressive conditions of various origins].
Topics: Amitriptyline; Antidepressive Agents; Depression; Desipramine; Dibenzazepines; Humans; Imipramine; Nortriptyline; Opipramol | 1966 |
[Restraining action of antidepressive agents of the imipramine group on the cardiovascular centers].
Topics: Action Potentials; Amitriptyline; Amygdala; Animals; Antidepressive Agents; Blood Pressure; Carotid Arteries; Cats; Desipramine; Hypertension; Hypothalamus; Imipramine; Medulla Oblongata; Mesencephalon; Nictitating Membrane; Nortriptyline; Rats; Sciatic Nerve; Splanchnic Nerves | 1967 |
[The separation of amitriptyline and nortriptyline using thin-layer chromatography].
Topics: Amitriptyline; Antidepressive Agents; Chromatography, Thin Layer; Nortriptyline | 1967 |
Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds.
Topics: Adult; Amitriptyline; Desipramine; Female; Humans; Imipramine; Male; Nortriptyline | 1967 |
[Clinical studies of a new antidepressive agent, nortriptyline].
Topics: Adolescent; Adult; Aged; Amitriptyline; Depression; Desipramine; Humans; Imipramine; Middle Aged; Neurotic Disorders; Nortriptyline | 1967 |
[Place of nortriptyline in the group of antidepressants; clinical and electroencephalographic considerations].
Topics: Amitriptyline; Depression; Humans; Imipramine; Nortriptyline | 1967 |
The contribution of alpha 1-acid glycoprotein, lipoproteins, and albumin to the plasma binding of perazine, amitriptyline, and nortriptyline in healthy man.
Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Humans; In Vitro Techniques; Kinetics; Lipoproteins; Nortriptyline; Orosomucoid; Perazine; Protein Binding; Serum Albumin | 1980 |
Amitriptyline pharmacokinetics. Lentizol and ordinary amitriptyline tablets compared in a cross-over study of steady state plasma drug levels in depressed patients.
Topics: Adult; Aged; Amitriptyline; Delayed-Action Preparations; Depressive Disorder; Female; Humans; Intestinal Absorption; Kinetics; Male; Middle Aged; Nortriptyline; Tablets | 1982 |
The contribution of pharmacokinetics to the best use of benzodiazepines and antidepressants.
Topics: Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Benzodiazepines; Depressive Disorder; Half-Life; Humans; Imipramine; Kinetics; Metabolic Clearance Rate; Nortriptyline | 1982 |
Weight gain. A side-effect of tricyclic antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Appetite; Body Weight; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Retrospective Studies | 1984 |
Interactions of tricyclic antidepressants with a synaptic ion channel.
Topics: Acetylcholine; Amitriptyline; Amphibian Venoms; Animals; Antidepressive Agents, Tricyclic; Binding Sites; Desipramine; Electric Organ; Fishes; Imipramine; Ion Channels; Nortriptyline; Phencyclidine; Receptors, Nicotinic | 1981 |
Differentiation of the open and closed states of the ionic channels of nicotinic acetylcholine receptors by tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Ion Channels; Kinetics; Membrane Potentials; Neuromuscular Junction; Nortriptyline; Rana pipiens; Receptors, Cholinergic; Receptors, Nicotinic | 1981 |
Steady state plasma concentration profiles and therapeutic response in anxious-depressed outpatients after administration of a chlordiazepoxide-amitriptyline combination.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Depressive Disorder; Drug Combinations; Female; Humans; Male; Middle Aged; Nordazepam; Nortriptyline | 1983 |
Ethanol effects on brain concentrations of amitriptyline and the relationship to psychomotor function.
Topics: Amitriptyline; Animals; Brain; Drug Synergism; Ethanol; Male; Metabolic Clearance Rate; Motor Activity; Nortriptyline; Psychomotor Performance; Rats; Rats, Inbred Strains | 1983 |
The demethylation of amitriptyline administered by oral and intramuscular routes.
Topics: Administration, Oral; Amitriptyline; Biotransformation; Dose-Response Relationship, Drug; Erythrocytes; Humans; Injections, Intramuscular; Kinetics; Metabolic Clearance Rate; Nortriptyline | 1983 |
Evaluation of the levels of free and total amitriptyline and metabolites in the plasma and brain of the rat after long-term administration of doses used in receptor studies.
Topics: Amitriptyline; Animals; Brain; Male; Nortriptyline; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Time Factors | 1984 |
Single-dose single-point method in amitriptyline therapy.
Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales | 1984 |
Symptoms as predictors of response to amitriptyline and nortriptyline -- the plasma level variable.
Topics: Amitriptyline; Depressive Disorder; Humans; Nortriptyline; Psychiatric Status Rating Scales | 1980 |
The nonlinear kinetics of desipramine and 2-hydroxydesipramine in plasma.
Topics: Administration, Oral; Adolescent; Adult; Aged; Amitriptyline; Chromatography, High Pressure Liquid; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Male; Middle Aged; Nortriptyline; Random Allocation | 1984 |
Weak binding of 10-hydroxymetabolites of nortriptyline to rat brain muscarinic acetylcholine receptors.
Topics: Amitriptyline; Animals; Binding, Competitive; Brain; In Vitro Techniques; Male; Nortriptyline; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Stereoisomerism | 1984 |
Serum levels and response to amitriptyline in depressed out-patients.
Topics: Adult; Aged; Ambulatory Care; Amitriptyline; Depressive Disorder; Double-Blind Method; Follow-Up Studies; Humans; Middle Aged; Nortriptyline; Time Factors | 1984 |
Blood collection tubes for tricyclic antidepressant drugs: a reevaluation.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Blood Preservation; Blood Proteins; Blood Specimen Collection; Desipramine; Humans; Imipramine; Nortriptyline; Plasma | 1984 |
REM latency distribution in major depression: clinical characteristics associated with sleep onset REM periods.
Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Electroencephalography; Female; Humans; Male; Middle Aged; Nortriptyline; Reaction Time; Sleep, REM | 1984 |
Resin haemoperfusion in levomepromazine poisoning: evaluation of effect on plasma drug and metabolite levels.
Topics: Adult; Amitriptyline; Electrocardiography; Female; Hemoperfusion; Humans; Male; Methotrimeprazine; Middle Aged; Nortriptyline; Platelet Count | 1984 |
Simultaneous measurement of various antidepressants in the plasma of depressed patients by high performance liquid chromatography.
Topics: Adult; Amitriptyline; Amoxapine; Antidepressive Agents; Chromatography, High Pressure Liquid; Clomipramine; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Male; Maprotiline; Middle Aged; Nortriptyline | 1984 |
Amitriptyline metabolism: relationship to polymorphic debrisoquine hydroxylation.
Topics: Adult; Amitriptyline; Debrisoquin; Female; Humans; Kinetics; Male; Middle Aged; Nortriptyline; Smoking | 1983 |
Liquid chromatographic separation of antidepressant drugs: I. Tricyclics.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline; Promazine; Protriptyline | 1983 |
Prolonged delirium without anticholinergic signs following amitriptyline overdose.
Topics: Amitriptyline; Delirium; Depression; Female; Humans; Nortriptyline; Parasympatholytics; Physostigmine; Sympathetic Nervous System | 1983 |
Quantification of amitriptyline, nortriptyline, and 10-hydroxy metabolite isomers in plasma by capillary gas chromatography with nitrogen-sensitive detection.
Topics: Amitriptyline; Chemical Phenomena; Chemistry; Chromatography, Gas; Humans; Nortriptyline | 1983 |
Assay for amitriptyline and nortriptyline facilitated by use of "toxi-tubes" for extraction.
Topics: Amitriptyline; Chromatography; Humans; Methods; Nortriptyline | 1984 |
Amitriptyline metabolism in relation to antidepressive effect.
Topics: Adult; Amitriptyline; Chromatography, High Pressure Liquid; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; Riboflavin | 1984 |
Gas chromatographic--mass spectrometric determination of amitriptyline and its major metabolites in human serum.
Topics: Amitriptyline; Biotransformation; Gas Chromatography-Mass Spectrometry; Humans; Male; Nortriptyline | 1984 |
Lidocaine and amitriptyline interaction during experimental haemoperfusion.
Topics: Amitriptyline; Animals; Brain; Dogs; Drug Interactions; Female; Hemoperfusion; Kinetics; Lidocaine; Liver; Lung; Male; Myocardial Contraction; Myocardium; Nortriptyline | 1984 |
Amitriptyline and its basic metabolites determined in plasma by gas chromatography.
Topics: Amines; Amitriptyline; Chromatography, Gas; Drug Stability; Humans; Nortriptyline; Plasma; Spectrophotometry, Ultraviolet | 1984 |
Inhibition of 5-hydroxytryptamine and noradrenaline uptake in platelets and synaptosomes incubated in plasma from human subjects treated with amitryptyline or nortriptyline: utilization of the principle for a bioassay method.
Topics: Adult; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Biological Assay; Blood Platelets; Humans; Norepinephrine; Nortriptyline; Rats; Serotonin; Synaptosomes | 1980 |
Binding of amitriptyline and nortriptyline in plasma determined from their equilibrium distributions between red cells and plasma, and between red cells and buffer solution.
Topics: Amitriptyline; Buffers; Chromatography, Gas; Contraceptives, Oral; Erythrocytes; Hydrogen-Ion Concentration; Lipids; Mathematics; Nortriptyline; Plasma; Temperature | 1981 |
Amitriptyline and nortriptyline excretion in human breast milk.
Topics: Adult; Amitriptyline; Depressive Disorder; Female; Humans; Milk, Human; Nortriptyline; Pregnancy; Puerperal Disorders | 1982 |
Do urinary MHPG and plasma drug levels correlate with response to amitriptyline therapy?
Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Female; Glycols; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales | 1982 |
Antidepressive effect and pharmacokinetics of amitriptyline with consideration of unbound drug and 10-hydroxynortriptyline plasma levels.
Topics: Adult; Aged; Amitriptyline; Biotransformation; Blood Proteins; Depressive Disorder; Female; Humans; Kinetics; Male; Methoxyhydroxyphenylglycol; Middle Aged; Nortriptyline; Protein Binding; Psychiatric Status Rating Scales | 1982 |
A liquid chromatographic method for quantitating amitriptyline in brain tissue.
Topics: Amitriptyline; Animals; Brain; Chromatography, High Pressure Liquid; Nortriptyline; Rats | 1982 |
Column deactivation in analysis for underivatized tricyclic antidepressants by gas chromatography with use of a nitrogen detector.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Clomipramine; Desipramine; Humans; Imipramine; Nitrogen; Nortriptyline | 1983 |
Complex inhibition of [3H]imipramine binding by serotonin and nontricyclic serotonin uptake blockers.
Topics: Amitriptyline; Animals; Binding, Competitive; Cerebral Cortex; Clomipramine; Desipramine; Imipramine; Male; Nortriptyline; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists | 1983 |
Organ levels of amitriptyline and nortriptyline in fatal amitriptyline poisoning.
Topics: Amitriptyline; Brain; Humans; Liver; Nortriptyline | 1983 |
The methylphenidate test for differentiating desipramine-responsive from nortriptyline-responsive depression.
Topics: Adolescent; Adult; Amitriptyline; Depressive Disorder; Desipramine; Emotions; Humans; Imipramine; Methylphenidate; Middle Aged; Norepinephrine; Nortriptyline | 1983 |
Determination of desmethyl nortriptyline in plasma by gas chromatography before and after treatment with salicylaldehyde.
Topics: Aldehydes; Amitriptyline; Chromatography, Gas; False Positive Reactions; Humans; Nortriptyline | 1983 |
Peripheral serotonergic and adrenergic responses in depression.
Topics: Affective Symptoms; Amitriptyline; Blood Platelets; Blood Pressure; Depression; Female; Humans; Male; Norepinephrine; Nortriptyline; Phenylephrine; Psychiatric Status Rating Scales; Receptors, Adrenergic; Serotonin; Tyramine | 1980 |
REM sleep, naps, and depression.
Topics: Adult; Amitriptyline; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Nortriptyline; Sleep; Sleep, REM; Time Factors | 1981 |
Plasma levels, psychophysiological variables, and clinical response to amitriptyline.
Topics: Adult; Aged; Amitriptyline; Arousal; Depressive Disorder; Female; Galvanic Skin Response; Habituation, Psychophysiologic; Heart Rate; Humans; Male; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales | 1982 |
Plasma concentrations of tricyclic antidepressants in clinical practice.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biotransformation; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Humans; Imipramine; Nortriptyline | 1982 |
Monitoring of tricyclic antidepressant therapy.
Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Depression; Female; Humans; Kinetics; Male; Middle Aged; Nortriptyline; Sex Factors | 1982 |
EEG sleep and tricyclic blood levels: acute and chronic administration in depression.
Topics: Adult; Age Factors; Amitriptyline; Depression; Female; Humans; Male; Nortriptyline; Personality Assessment; Sleep, REM | 1982 |
Tricyclic antidepressant plasma levels: the state of the art and clinical prospects.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biotransformation; Bipolar Disorder; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Imipramine; Nortriptyline | 1982 |
TCA-induced mania: differences between switchers and nonswitchers.
Topics: Adult; Affective Disorders, Psychotic; Age Factors; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder; Desipramine; Doxepin; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Protriptyline | 1982 |
Importance of evaporation conditions and two internal standards for quantitation of amitriptyline and nortriptyline.
Topics: Amitriptyline; Chromatography, High Pressure Liquid; False Negative Reactions; Humans; Nortriptyline; Reference Values | 1982 |
Single dose prediction of steady state plasma levels of amitriptyline.
Topics: Adolescent; Adult; Aged; Amitriptyline; Chromatography, High Pressure Liquid; Depressive Disorder; Female; Humans; Kinetics; Male; Middle Aged; Nortriptyline | 1982 |
Early improvement as a predictor of response to amitriptyline and nortriptyline: a comparison of 2 patient samples.
Topics: Age Factors; Amitriptyline; Depressive Disorder; Drug Evaluation; Female; Humans; Male; Nortriptyline; Prognosis; Random Allocation; Time Factors | 1982 |
Nortriptyline and EEG sleep in depressed patients.
Topics: Adult; Amitriptyline; Bipolar Disorder; Depressive Disorder; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Female; Humans; Male; Nortriptyline; Sleep Stages; Sleep, REM | 1982 |
Plasma binding variations of amitriptyline and nortriptyline.
Topics: Adult; Aged; Amitriptyline; Blood Proteins; Female; Humans; Male; Middle Aged; Nortriptyline; Orosomucoid; Protein Binding | 1982 |
Simultaneous determination of amitriptyline, nortriptyline and their respective isomeric 10-hydroxy metabolites in plasma by liquid chromatography.
Topics: Amitriptyline; Chromatography, Liquid; Humans; Nortriptyline; Reference Values | 1982 |
Lack of cross-allergenicity between tricyclic antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Hypersensitivity; Erythema; Female; Humans; Male; Nortriptyline | 1982 |
Dependence of salivary drug concentration on salivary flow rate.
Topics: Amitriptyline; Humans; Iodides; Iodine; Lithium; Male; Nortriptyline; Pharmaceutical Preparations; Salicylates; Saliva; Salivation; Theophylline | 1982 |
Interaction between antidepressants and perphenazine in psychiatric inpatients.
Topics: Adult; Amitriptyline; Depressive Disorder; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Hospitalization; Humans; Male; Nortriptyline; Perphenazine; Stimulation, Chemical | 1982 |
Significance of lipoproteins in serum binding variations of amitriptyline, nortriptyline, and quinidine.
Topics: Adult; Aged; Amitriptyline; Cholesterol; Female; Humans; Lipoproteins; Male; Middle Aged; Nortriptyline; Quinidine; Triglycerides | 1982 |
Nortriptyline formation after single oral and intramuscular doses of amitriptyline.
Topics: Administration, Oral; Amitriptyline; Biotransformation; Female; Humans; Injections, Intramuscular; Male; Nortriptyline; Time Factors | 1982 |
On the relationship between free plasma and saliva amitriptyline and nortriptyline.
Topics: Amitriptyline; Depressive Disorder; Humans; Hydrogen-Ion Concentration; Nortriptyline; Saliva; Time Factors | 1982 |
Bonded-phase extraction of plasma tricyclic antidepressant drugs for gas chromatographic analysis.
Topics: Acetates; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Desipramine; Humans; Imipramine; Methods; Nortriptyline | 1982 |
Experimental studies on the effects of physostigmine and of isoproterenol on toxicity produced by tricyclic antidepressant agents.
Topics: Amitriptyline; Animals; Blood Pressure; Cats; Drug Interactions; Electrocardiography; Female; Heart Rate; Infusions, Parenteral; Isoproterenol; Male; Myocardial Contraction; Nortriptyline; Physostigmine | 1982 |
A sensitive gas chromatographic assay for amitriptyline and nortriptyline in plasma.
Topics: Amitriptyline; Chromatography, Gas; Humans; Nortriptyline | 1982 |
Role of oxidation polymorphism on blood and urine concentrations of amitriptyline and its metabolites in man.
Topics: Adult; Amitriptyline; Biotransformation; Female; Humans; Male; Nortriptyline; Oxidation-Reduction; Polymorphism, Genetic | 1982 |
Amitriptyline overdose: clinical effects on tricyclic antidepressant plasma levels.
Topics: Adolescent; Adult; Age Factors; Amitriptyline; Black or African American; Female; Humans; Male; Mental Disorders; Middle Aged; Nortriptyline; Retrospective Studies; Sex Factors | 1982 |
The relationship of therapeutic response to antidepressant plasma levels: an update.
Topics: Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents; Biological Availability; Depressive Disorder; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline; Patient Compliance; Protriptyline | 1982 |
Evidence for in vivo methylation of the secondary amino antidepressant desipramine to imipramine in humans.
Topics: Amitriptyline; Biotransformation; Depressive Disorder; Desipramine; Humans; Imipramine; Methylation; Nortriptyline | 1982 |
Quality control of amitriptyline and nortriptyline plasma level assessments: a multicenter study.
Topics: Amitriptyline; Chemistry, Clinical; Humans; Nortriptyline; Quality Control | 1982 |
Pharmacokinetics of amitriptyline in the elderly.
Topics: Aged; Amitriptyline; Electrocardiography; Hemodynamics; Humans; Kinetics; Nortriptyline | 1981 |
Simultaneous liquid chromatographic analysis of amitriptyline, nortriptyline, imipramine, desipramine, doxepin, and nordoxepin.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline | 1981 |
MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study.
Topics: Adult; Amitriptyline; Anxiety Disorders; Blood Platelets; Female; Humans; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nortriptyline; Pilot Projects | 1981 |
Liquid-chromatographic analysis for common tricyclic antidepressant drugs and their metabolites in serum or plasma with the technicon "FAST-LC" system.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Autoanalysis; Chromatography, High Pressure Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline; Protriptyline | 1981 |
Effect of alcohol consumption and cigarette smoking on antidepressant levels of depressed patients.
Topics: Adult; Alcohol Drinking; Amitriptyline; Depressive Disorder; Female; Humans; Nortriptyline; Smoking | 1981 |
Radioimmunoassay for tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Humans; Nortriptyline; Radioimmunoassay | 1980 |
Fatal nortriptyline overdose, plasma levels, and in vivo methylation of tricyclic antidepressants.
Topics: Adult; Amitriptyline; Biotransformation; Chromatography, Gas; Female; Humans; Mass Spectrometry; Methylation; Nortriptyline; Suicide | 1981 |
Amitriptyline and nortriptyline plasma levels monitoring. Perspective in clinical practice.
Topics: Amitriptyline; Depressive Disorder; Female; Humans; Nortriptyline; Psychiatric Status Rating Scales | 1980 |
Reliability of tricyclic antidepressant levels -- further questions.
Topics: Amitriptyline; Humans; Nortriptyline | 1981 |
Tricyclic antidepressants: clinical use of plasma levels.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Child; Confusion; Depressive Disorder; Electrocardiography; Hallucinations; Humans; Nortriptyline; Patient Compliance | 1981 |
Cognitive improvement associated with tricyclic antidepressant treatment of childhood major depressive illness.
Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Cognition; Depressive Disorder; Desipramine; Female; Humans; Intelligence; Male; Nortriptyline; Psychiatric Status Rating Scales | 1981 |
Reversed-phase liquid chromatography and gas chromatography/mass fragmentography compared for determination of tricyclic antidepressant drugs.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Nortriptyline | 1981 |
Tricyclic antidepressant blood levels: eight practical questions.
Topics: Age Factors; Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Dose-Response Relationship, Drug; Humans; Imipramine; Intestinal Absorption; Nortriptyline | 1981 |
Antidepressants inhibit enkephalin binding to synaptosome-enriched fractions of rat brain.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Imipramine; Male; Nortriptyline; Rats; Rats, Inbred Strains; Synaptosomes; Viloxazine | 1981 |
[Comparison of the effectiveness of tranylcypromine, nortriptyline, thioridazine and amitriptyline in two syndromological types of endogenous depression (author's transl)].
Topics: Adult; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; Thioridazine; Tranylcypromine | 1981 |
Tricyclic antidepressants: a simplified approach for the routine clinical monitoring of parent drug and metabolites in plasma using HPLC.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Humans; Imipramine; Monitoring, Physiologic; Nortriptyline | 1981 |
Slow tricyclic antidepressant metabolism, polypharmacy, and cardiac arrest.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biological Availability; Drug Combinations; Drug Interactions; Female; Heart Arrest; Humans; Middle Aged; Nortriptyline | 1980 |
Electrocardiographic and cardiovascular changes in cats and dogs caused by high doses of amitriptyline given as conventional tablets or a sustained release preparation.
Topics: Amitriptyline; Animals; Cats; Delayed-Action Preparations; Dogs; Electrocardiography; Hemodynamics; Male; Nortriptyline; Tablets | 1980 |
Plasma concentrations of amitriptyline during single nightly and thrice daily administration. Cross-over study.
Topics: Amitriptyline; Drug Administration Schedule; Female; Humans; Nortriptyline; Time Factors | 1980 |
Reliability of commercially available tricyclic antidepressant levels.
Topics: Amitriptyline; Depression; Humans; Nortriptyline | 1980 |
Amitriptyline in human breast milk and the nursing infant's serum.
Topics: Adult; Amitriptyline; Depression; Female; Humans; Infant, Newborn; Milk, Human; Nortriptyline; Pregnancy | 1980 |
Quantitative analysis for tricyclic antidepressant drugs in plasma or serum by gas chromatography-chemical-ionization mass spectrometry.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Desipramine; Female; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Male; Middle Aged; Nortriptyline | 1980 |
Some factors affecting the plasma levels of tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Clomipramine; Delayed-Action Preparations; Drug Administration Schedule; Erythrocytes; Female; Humans; Ileum; Male; Middle Aged; Nortriptyline | 1980 |
Plasma levels and clinical improvement--a comparative study of clomipramine and amitriptyline in depression.
Topics: Amitriptyline; Clomipramine; Depression; Female; Humans; Male; Nortriptyline | 1980 |
An external quality-control scheme for tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Blood Chemical Analysis; Desipramine; Humans; Imipramine; Laboratories; Nortriptyline; Quality Control; United Kingdom | 1980 |
Amitriptyline, nortriptyline plasma levels and clinical response in women with affective disorders.
Topics: Adjustment Disorders; Adult; Aged; Amitriptyline; Bipolar Disorder; Depression; Depressive Disorder, Major; Dose-Response Relationship, Drug; Female; Humans; Middle Aged; Nortriptyline | 1980 |
On the relationship of nortriptyline: amitriptyline ratio to clinical improvement of amitriptyline treated depressive patients.
Topics: Adult; Amitriptyline; Bipolar Disorder; Depression; Humans; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales | 1980 |
Neuropharmacological properties of amitriptyline, nortriptyline and their metabolites.
Topics: Amitriptyline; Animals; Blood Platelets; Guinea Pigs; Mice; Myocardium; Norepinephrine; Nortriptyline; Rabbits; Serotonin | 1980 |
Urinary MHPG and clinical response to amitriptyline in depressed patients.
Topics: Adolescent; Adult; Amitriptyline; Depressive Disorder; Female; Glycols; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales | 1980 |
Determination of amitriptyline-N-oxide, amitriptyline and nortriptyline in serum and plasma by high-performance liquid chromatography.
Topics: Amitriptyline; Animals; Chromatography, High Pressure Liquid; Diazepam; Male; Nortriptyline; Rats | 1980 |
Decreased tyramine sensitivity after discontinuation of amitriptyline therapy. An index of pharmacodynamic half-life.
Topics: Adult; Amitriptyline; Blood Pressure; Depression; Drug Interactions; Female; Half-Life; Humans; Male; Middle Aged; Nortriptyline; Substance Withdrawal Syndrome; Tyramine | 1980 |
Prediction of steady-state plasma levels of amitriptyline and nortriptyline from a single dose 24 hr. level in depressed patients.
Topics: Amitriptyline; Delayed-Action Preparations; Depressive Disorder; Female; Humans; Male; Nortriptyline | 1980 |
Drug interactions of amitriptyline and nortriptyline with warfarin in the rat.
Topics: Amitriptyline; Animals; Drug Interactions; Half-Life; Kinetics; Liver; Male; Mixed Function Oxygenases; Nortriptyline; Prothrombin Time; Rats; Warfarin | 1980 |
Clinical findings, elimination pharmacokinetics, and tissue drug concentrations following a fatal amitriptyline intoxication.
Topics: Adult; Amitriptyline; Humans; Kinetics; Male; Metabolic Clearance Rate; Nortriptyline; Suicide; Tissue Distribution | 1981 |
N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors.
Topics: 1-Naphthylamine; Amitriptyline; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Isoenzymes; Ketoconazole; Kinetics; Liver; Mixed Function Oxygenases; Nortriptyline; Quinidine; Selective Serotonin Reuptake Inhibitors; Sertraline | 1995 |
Clomipramine and clonazepam increase cholecystokinin levels in rat ventral tegmental area and limbic regions.
Topics: Amitriptyline; Animals; Cholecystokinin; Clomipramine; Clonazepam; Infusion Pumps, Implantable; Limbic System; Male; Nortriptyline; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P; Ventral Tegmental Area | 1994 |
Interindividual variations of desmethylation and hydroxylation of amitriptyline in a Japanese psychiatric population.
Topics: Adult; Aged; Amitriptyline; Biotransformation; Dose-Response Relationship, Drug; Female; Humans; Hydroxylation; Japan; Male; Mental Disorders; Methylation; Middle Aged; Nortriptyline | 1995 |
Mice plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after half-life repeated administration. Comparison with acute administration.
Topics: Amitriptyline; Animals; Brain; Dealkylation; Half-Life; Male; Mice; Nortriptyline | 1994 |
Secretion of amitriptyline and metabolites into breast milk.
Topics: Adult; Amitriptyline; Bipolar Disorder; Female; Humans; Infant, Newborn; Milk, Human; Nortriptyline; Postpartum Period; Pregnancy; Pregnancy Complications | 1995 |
Postmortem changes in blood amitriptyline concentration.
Topics: Adult; Amitriptyline; Body Fluids; Chromatography, High Pressure Liquid; Drug Overdose; Humans; Male; Nortriptyline; Postmortem Changes; Salicylates; Suicide | 1994 |
The use of therapeutic drug monitoring data to document kinetic drug interactions: an example with amitriptyline and nortriptyline.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Antipsychotic Agents; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Female; Humans; Male; Middle Aged; Models, Biological; Nortriptyline; Phenothiazines; Retrospective Studies | 1994 |
Initiation of tricyclic treatment at full dose.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Drug Administration Schedule; Humans; Hypotension, Orthostatic; Nortriptyline | 1994 |
Immunoassay reagents for psychoactive drugs. Part 4. Quantitative determination of amitriptyline and nortriptyline by fluorescence polarization immunoassay.
Topics: Amitriptyline; Animals; Chromatography, High Pressure Liquid; Cross Reactions; Fluorescence Polarization Immunoassay; Fluorescent Dyes; Humans; Indicators and Reagents; Nortriptyline; Psychotropic Drugs; Rabbits; Solvents | 1994 |
Distribution of amitriptyline and nortriptyline in blood: role of alpha-1-glycoprotein.
Topics: Aging; Amitriptyline; Chromatography, High Pressure Liquid; Erythrocytes; Fetal Blood; Humans; Nortriptyline; Orosomucoid; Protein Binding; Serum Albumin | 1993 |
Concurrent liquid chromatographic measurement of fluoxetine, amitriptyline, imipramine, and their active metabolites norfluoxetine, nortriptyline, and desipramine in plasma.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Desipramine; Fluoxetine; Humans; Imipramine; Indicators and Reagents; Nortriptyline; Spectrophotometry, Ultraviolet | 1993 |
Dual ultraviolet wavelength high-performance liquid chromatographic method for the forensic or clinical analysis of seventeen antidepressants and some selected metabolites.
Topics: Amitriptyline; Antidepressive Agents; Chromatography, High Pressure Liquid; Dothiepin; Doxepin; Forensic Medicine; Humans; Microchemistry; Nortriptyline; Postmortem Changes; Quality Control | 1993 |
The study of tricyclic antidepressants in formalin-fixed human liver and formalin solutions.
Topics: Amitriptyline; Cryopreservation; Desipramine; Drug Overdose; Drug Stability; Embalming; Evaluation Studies as Topic; Forensic Medicine; Formaldehyde; Humans; Imipramine; Liver; Methylation; Nortriptyline; Poisoning; Temperature; Time Factors | 1993 |
[Relationship between amitriptyline metabolism and polymorphic debrisoquine hydroxylation in native Chinese volunteers].
Topics: Adult; Amitriptyline; Asian People; Debrisoquin; Humans; Hydroxylation; Male; Metabolic Clearance Rate; Nortriptyline; Phenotype; Polymorphism, Genetic; Species Specificity | 1993 |
An animal model of postmortem amitriptyline redistribution.
Topics: Amitriptyline; Animals; Disease Models, Animal; Drug Overdose; Liver; Lung; Male; Nortriptyline; Postmortem Changes; Rats; Rats, Wistar; Tissue Distribution | 1993 |
Preliminary observations of the effects of amitriptyline in decomposing tissues on the development of Parasarcophaga ruficornis (Diptera: Sarcophagidae) and implications of this effect to estimation of postmortem interval.
Topics: Amitriptyline; Animals; Diptera; Forensic Medicine; Larva; Liver; Nortriptyline; Postmortem Changes; Rabbits; Time Factors; Tissue Distribution | 1993 |
Immunoassay reagents for psychoactive drugs. I. The method for the development of antibodies specific to amitriptyline and nortriptyline.
Topics: Amitriptyline; Animals; Antibodies; Antibody Specificity; Chlorpromazine; Cross Reactions; Fluorescence Polarization; Immunologic Techniques; Indicators and Reagents; Models, Molecular; Nortriptyline; Rabbits; Sensitivity and Specificity | 1993 |
[Toxic tricyclic drug plasma level caused by fluoxetine].
Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depressive Disorder; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fluoxetine; Heart Block; Humans; Metabolic Clearance Rate; Middle Aged; Nortriptyline; Recurrence | 1995 |
Effects of divalproex sodium on amitriptyline and nortriptyline pharmacokinetics.
Topics: Adult; Amitriptyline; Anticonvulsants; Antidepressive Agents, Tricyclic; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Male; Middle Aged; Nortriptyline; Valproic Acid | 1996 |
Dosing of antidepressants--the unknown art.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Nortriptyline | 1995 |
Enzyme kinetic modelling as a tool to analyse the behaviour of cytochrome P450 catalysed reactions: application to amitriptyline N-demethylation.
Topics: Amitriptyline; Catalysis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Inhibitors; Humans; In Vitro Techniques; Ketoconazole; Least-Squares Analysis; Microsomes, Liver; Models, Biological; Nortriptyline; Sulfaphenazole | 1996 |
Pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites in streptozocin-induced diabetic rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brain; Diabetes Mellitus, Experimental; Hydroxylation; Injections, Intraperitoneal; Male; Nortriptyline; Rats; Rats, Sprague-Dawley | 1996 |
Distribution of venlafaxine in three postmortem cases.
Topics: Acetaminophen; Adult; Amitriptyline; Antidepressive Agents, Second-Generation; Bile; Chlordiazepoxide; Chromatography, Gas; Cyclohexanols; Diphenhydramine; Humans; Kidney; Liver; Male; Methylation; Middle Aged; Nortriptyline; Reference Standards; Selective Serotonin Reuptake Inhibitors; Suicide; Venlafaxine Hydrochloride | 1996 |
Plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after one and six half-life repeated administrations to rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brain; Half-Life; Male; Nortriptyline; Rats; Rats, Sprague-Dawley | 1996 |
Simultaneous determination of amitriptyline, nortriptyline and four hydroxylated metabolites in serum by capillary gas-liquid chromatography with nitrogen-phosphorus-selective detection.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Calibration; Chromatography, Gas; Drug Monitoring; Humans; Nitrogen; Nortriptyline; Phosphorus; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 1996 |
Quantitative analysis of amitriptyline and nortriptyline in human plasma and liver microsomal preparations by high-performance liquid chromatography.
Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Humans; Ketoconazole; Linear Models; Microsomes, Liver; Nortriptyline; Osmolar Concentration; Rats; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Time Factors | 1996 |
Possible markers for postmortem drug redistribution.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Amino Acids; Amitriptyline; Antidepressive Agents; Aspartate Aminotransferases; Bile; Bilirubin; Biomarkers; Blood Glucose; Duodenum; Female; Forensic Medicine; gamma-Glutamyltransferase; Humans; Jejunum; Liver; Lung; Methionine; Muscle, Skeletal; Nortriptyline; Postmortem Changes; Tissue Distribution; Vitreous Body | 1997 |
The Pisa syndrome (pleurothotonus) during antidepressant therapy.
Topics: Amitriptyline; Antidepressive Agents; Biperiden; Depressive Disorder; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Humans; Imipramine; Male; Maprotiline; Middle Aged; Nortriptyline; Orientation; Postural Balance; Posture | 1997 |
Regioselectivity and substrate concentration-dependency of involvement of the CYP2D subfamily in oxidative metabolism of amitriptyline and nortriptyline in rat liver microsomes.
Topics: Amitriptyline; Animals; Antidepressive Agents; Biotransformation; Cytochrome P-450 CYP2D6; Female; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nortriptyline; Oxidation-Reduction; Rats; Rats, Wistar; Sex Characteristics; Sparteine | 1996 |
Metabolism of amitriptyline with CYP2D6 expressed in a human cell line.
Topics: Acylation; Amitriptyline; Antidepressive Agents, Tricyclic; Cell Line; Chromatography, Gas; Cytochrome P-450 CYP2D6; Humans; Microsomes; Nortriptyline | 1997 |
Cytochromes P450 mediating the N-demethylation of amitriptyline.
Topics: Amitriptyline; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Methylation; Microsomes, Liver; Nortriptyline | 1997 |
Acute lung failure induced by tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Overdose; Imipramine; Lung; Maprotiline; Mianserin; Microscopy, Electron; Nortriptyline; Organ Size; Perfusion; Pulmonary Edema; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley | 1997 |
Amitriptyline accumulation and elimination in Calliphora vicina larvae.
Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents; Chromatography, High Pressure Liquid; Diptera; Dose-Response Relationship, Drug; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Larva; Nortriptyline; Pupa; Time Factors | 1997 |
Quantitative determination of tricyclic antidepressants and their metabolites in plasma by solid-phase extraction (Bond-Elut TCA) and separation by capillary gas chromatography with nitrogen-phosphorous detection.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Clomipramine; Desipramine; Drug Monitoring; Humans; Imipramine; Linear Models; Nortriptyline; Promazine; Sensitivity and Specificity | 1998 |
Isotope dilution gas chromatographic-mass spectrometric measurement of tricyclic antidepressant drugs. Utility of the 4-carbethoxyhexafluorobutyryl derivatives of secondary amines.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Deuterium; Drug Stability; Fluorocarbons; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Nortriptyline; Reference Standards; Reproducibility of Results | 1998 |
Stability of tricyclic antidepressants in formalin solutions.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Drug Stability; Forensic Medicine; Formaldehyde; Imipramine; Nortriptyline; Substance Abuse Detection; Time Factors | 1998 |
Nonaqueous capillary electrophoretic separation and thermo-optical absorbance detection of five tricyclic antidepressants and metabolism of amitriptyline by Cunninghamella elegans.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Cunninghamella; Desipramine; Electrophoresis, Capillary; Imipramine; Molecular Structure; Nortriptyline | 1998 |
Redistribution of basic drugs into cardiac blood from surrounding tissues during early-stages postmortem.
Topics: Adult; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Autopsy; Central Nervous System Stimulants; Chromatography, Gas; Coronary Circulation; Drug Overdose; Female; Gas Chromatography-Mass Spectrometry; Histamine H1 Antagonists; Humans; Illicit Drugs; Male; Methamphetamine; Middle Aged; Morphine; Narcotics; Nortriptyline; Postmortem Changes; Promethazine; Rabbits; Tissue Distribution | 1999 |
Determination of amitriptyline and nortriptyline in human liver microsomes with reversed-phase HPLC in vitro.
Topics: Amitriptyline; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Microsomes, Liver; Nortriptyline | 1998 |
Relaxant effects of antidepressants on human isolated mesenteric arteries.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Electric Stimulation; Female; Humans; In Vitro Techniques; Male; Mesenteric Arteries; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nortriptyline; Potassium Chloride; Sertraline | 1999 |
Amitriptyline-induced loss of tight junction integrity in a human endothelial--smooth muscle cell bi-layer model.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Coculture Techniques; Desipramine; Electric Impedance; Endothelium, Vascular; Fluorescent Antibody Technique, Indirect; Formazans; Humans; Imipramine; Muscle, Smooth, Vascular; Nortriptyline; Spectrometry, Fluorescence; Tetrazolium Salts; Tight Junctions; Umbilical Cord | 1999 |
Spectrophotometric determination of some antidepressant drugs using 3-methylbenzothiazolin-2-one hydrazone.
Topics: Amitriptyline; Antidepressive Agents; Benzothiazoles; Chlorides; Doxepin; Excipients; Ferric Compounds; Hydrazones; Hydrochloric Acid; Nortriptyline; Spectrophotometry; Thiazoles; Time Factors | 1999 |
Nonspecific binding of drugs to human liver microsomes.
Topics: Amitriptyline; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Models, Biological; Nortriptyline | 2000 |
Effects of antidepressants on weight and on the plasma levels of leptin, TNF-alpha and soluble TNF receptors: A longitudinal study in patients treated with amitriptyline or paroxetine.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Body Weight; Female; Humans; Leptin; Longitudinal Studies; Male; Middle Aged; Multivariate Analysis; Nortriptyline; Paroxetine; Receptors, Leptin; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2000 |
Transplacental transfer of amitriptyline and nortriptyline in isolated perfused human placenta.
Topics: Adult; Algorithms; Amitriptyline; Antidepressive Agents, Tricyclic; Blood Gas Analysis; Female; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Nortriptyline; Perfusion; Placenta; Pregnancy | 2001 |
Capillary electrochromatography of hydrophobic amines on continuous beds.
Topics: Amines; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Micellar Electrokinetic Capillary; Electrophoresis, Capillary; Molecular Structure; Nortriptyline | 2001 |
Salmon calcitonin potentiates the analgesia induced by antidepressants.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain Chemistry; Calcitonin; Depression; Dose-Response Relationship, Drug; Drug Synergism; Hydroxyindoleacetic Acid; Male; Mice; Nortriptyline; Paroxetine; Selective Serotonin Reuptake Inhibitors; Serotonin; Swimming | 2001 |
Cyclobenzaprine hydrochloride is a commonly prescribed centrally acting muscle relaxant, which is structurally similar to tricyclic antidepressants (TCAs) and differs from amitriptyline by only one double bond.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Drug Therapy, Combination; Humans; Male; Muscle Relaxants, Central; Nortriptyline; Pain | 2001 |
Sample preparation with fiber-in-tube solid-phase microextraction for capillary electrophoretic separation of tricyclic antidepressant drugs in human urine.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Imipramine; Nortriptyline; Specimen Handling | 2001 |
Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John's wort ( Hypericum perforatum ).
Topics: Adult; Amitriptyline; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypericum; Male; Metabolic Clearance Rate; Middle Aged; Nortriptyline; Phytotherapy; Plant Extracts | 2002 |
Inhibition of acetylcholinesterase from Electrophorus electricus (L.) by tricyclic antidepressants.
Topics: Acetylcholinesterase; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cholinesterase Inhibitors; Coloring Agents; Electrophorus; Imipramine; Molecular Structure; Nortriptyline; Propidium; Protein Binding; Spectrometry, Fluorescence | 2002 |
Charcoal enhancement of treatment for tricyclic-induced mania.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Antidotes; Bipolar Disorder; Charcoal; Depressive Disorder; Drug Overdose; Female; Humans; Nortriptyline; Treatment Outcome; Valproic Acid | 2002 |
Toxicokinetics of nortriptyline and amitriptyline: two case reports.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Drug Overdose; Female; Humans; Immunoassay; Middle Aged; Nortriptyline | 2003 |
AMITRIPTYLINE AND NORTRIPTYLINE AS ANTAGONISTS OF CENTRAL AND PERIPHERAL CHOLINERGIC ACTIVATION.
Topics: Amitriptyline; Animals; Antidepressive Agents; Central Nervous System; Cholinergic Agents; Dogs; Guinea Pigs; Ileum; Nervous System; Nortriptyline; Parasympatholytics; Peripheral Nerves; Research; Salivation | 1963 |
THE METABOLISM OF NORTRIPTYLINE-N-METHYL-14C IN RATS.
Topics: Amitriptyline; Antidepressive Agents; Carbon Isotopes; Metabolism; Nortriptyline; Rats; Research | 1963 |
A STUDY OF THE ANTIANXIETY EFFECT OF NORTRIPTYLINE IN UROLOGICAL PATIENTS.
Topics: Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Anxiety Disorders; Biomedical Research; Nortriptyline; Toxicology; Urology | 1964 |
NORTRIPTYLINE: A NEW ANTIDEPRESSANT EVALUATED IN A GENERAL MEDICAL PRACTICE.
Topics: Amitriptyline; Antidepressive Agents; Anxiety; Anxiety Disorders; Biomedical Research; Geriatrics; Nortriptyline; Pharmacology; Placebos; Toxicology | 1964 |
COMPARATIVE TRIAL OF NORTRIPTYLINE AND AMITRIPTYLINE.
Topics: Amitriptyline; Antidepressive Agents; Biomedical Research; Depression; Drug Therapy; Geriatrics; Nortriptyline; Toxicology | 1964 |
THE EFFECT OF NORTRIPTYLINE AND AMITRIPTYLINE ON THE GASTRIC SECRETION.
Topics: Amitriptyline; Biomedical Research; Digestion; Gastric Juice; Nortriptyline; Pepsin A; Pharmacology; Placebos; Tyrosine | 1965 |
[TREATMENT OF ENDOGENOUS DEPRESSIONS WITH ANTIDEPRESSIVE AGENTS AND ELECTROSHOCK AND TREATMENT BEFORE 1937].
Topics: Amitriptyline; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Electroconvulsive Therapy; Electroshock; Humans; Imipramine; Mental Disorders; Monoamine Oxidase Inhibitors; Nortriptyline; Psychotherapy | 1964 |
THE DIAGNOSIS AND MANAGEMENT OF DEPRESSION.
Topics: Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Classification; Depression; Depressive Disorder; Desipramine; Diagnosis; Drug Therapy; Humans; Imipramine; Monoamine Oxidase Inhibitors; Nortriptyline; Tyramine | 1965 |
[MEDICAL ANTIDEPRESSIVE TREATMENT. NORTRIPTYLINE EVALUATED IN COMPARISON WITH AMITRIPTYLINE AND IMIPRAMINE].
Topics: Adolescent; Amitriptyline; Antidepressive Agents; Depression; Depressive Disorder; Geriatrics; Imipramine; Nortriptyline; Toxicology | 1965 |
ATTEMPT TO DIFFERENTIATE THYMOLEPTICS AND NEUROLEPTICS BY MEANS OF THEIR INFLUENCE ON THE EFFECTS OF RESERPINE.
Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Body Temperature; Chlorpromazine; Chlorprothixene; Desipramine; Eyelids; Imipramine; Mice; Nortriptyline; Peptic Ulcer; Pharmacology; Rats; Research; Reserpine; Toxicology; Tranquilizing Agents | 1964 |
PHARMACOLOGICAL PROPERTIES OF THE DESMETHYL DERIVATIVES OF SOME ANTIDEPRESSANTS OF IMIPRAMINE TYPE.
Topics: Amitriptyline; Animals; Antidepressive Agents; Caffeine; Desipramine; Hypothermia; Hypothermia, Induced; Imipramine; Injections, Intraperitoneal; Mice; Nortriptyline; Pentylenetetrazole; Peptic Ulcer; Rats; Research; Reserpine; Selective Serotonin Reuptake Inhibitors; Serotonin; Strychnine; Toxicology; Tranquilizing Agents | 1965 |
P-glycoprotein reduces the ability of amitriptyline metabolites to cross the blood brain barrier in mice after a 10-day administration of amitriptyline.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Chromatography, High Pressure Liquid; Drug Administration Schedule; Injections, Subcutaneous; Male; Mice; Mice, Knockout; Nortriptyline; Tissue Distribution | 2004 |
Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers.
Topics: Adult; Aged; Alleles; Amitriptyline; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Depression; DNA; Female; Genotype; Humans; Male; Middle Aged; Mixed Function Oxygenases; Nortriptyline; Pharmacogenetics; Polymerase Chain Reaction; Prospective Studies; Statistics, Nonparametric | 2004 |
Excess fatality from desipramine and dosage recommendations.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Databases, Factual; Desipramine; Drug Overdose; Humans; Imipramine; Nortriptyline; United Kingdom; United States | 2004 |
High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Bromodeoxyuridine; Cell Count; Cell Proliferation; Dose-Response Relationship, Drug; Drosophila Proteins; Drug Interactions; Helplessness, Learned; Hindlimb Suspension; Hippocampus; Immunohistochemistry; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nicotinic Antagonists; Nortriptyline; Receptors, Nicotinic; Swimming | 2004 |
Interactions of cyclobenzaprine and tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Interactions; Humans; Male; Middle Aged; Nortriptyline; Pain; Sleep Initiation and Maintenance Disorders; Syncope | 2005 |
Effect of anionic additive type on ion pair formation constants of basic pharmaceuticals.
Topics: Amitriptyline; Anions; Chlorides; Electrophoresis, Capillary; Formates; Mathematics; Nortriptyline; Osmolar Concentration; Perchlorates; Perphenazine; Pharmaceutical Preparations; Trifluoroacetic Acid | 2005 |
Amitriptyline and nortriptyline inhibit interleukin-1 release by rat mixed glial and microglial cell cultures.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Astrocytes; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Dose-Response Relationship, Drug; Interleukin-1; Lipopolysaccharides; Microglia; Neuroglia; Nortriptyline; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2006 |
CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Forensic Medicine; Gene Frequency; Genotype; Humans; Mixed Function Oxygenases; Nortriptyline | 2006 |
Tissue distribution of mirtazapine and desmethylmirtazapine in a case of mirtazapine poisoning.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Bile; Brain Chemistry; Forensic Pathology; Gas Chromatography-Mass Spectrometry; Gastrointestinal Contents; Humans; Kidney; Liver; Lung; Male; Mianserin; Mirtazapine; Muscle, Skeletal; Nortriptyline; Sertraline; Suicide; Tissue Distribution | 2006 |
Separation mechanism of nortriptyline and amytriptyline in RPLC.
Topics: Adsorption; Amitriptyline; Chromatography, High Pressure Liquid; Computer Simulation; Models, Chemical; Nortriptyline | 2005 |
Excess fatality from desipramine in children and adolescents.
Topics: Adolescent; Amitriptyline; Child; Desipramine; Doxepin; Humans; Imipramine; Incidence; Mortality; Nortriptyline; Prevalence; Substance-Related Disorders | 2006 |
Study of overload for basic compounds in reversed-phase high performance liquid chromatography as a function of mobile phase pH.
Topics: Amitriptyline; Amphetamine; Chromatography, High Pressure Liquid; Diphenhydramine; Hydrogen-Ion Concentration; Nortriptyline; Quaternary Ammonium Compounds; Silanes | 2006 |
Optimization of solid-phase microextraction procedures for the determination of tricyclic antidepressants and anticonvulsants in plasma samples by liquid chromatography.
Topics: Amitriptyline; Anticonvulsants; Antidepressive Agents, Tricyclic; Carbamazepine; Chromatography, Liquid; Desipramine; Epoxy Compounds; Humans; Hydrogen-Ion Concentration; Imipramine; Lamotrigine; Nortriptyline; Phenobarbital; Phenylethylmalonamide; Polyurethanes; Primidone; Reproducibility of Results; Sensitivity and Specificity; Silanes; Time Factors; Triazines | 2006 |
Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuralgia; Nortriptyline; Receptors, Opioid, delta; Sciatica | 2008 |
The CYP2D6 polymorphism in relation to the metabolism of amitriptyline and nortriptyline in the Faroese population.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Denmark; Female; Humans; Male; Middle Aged; Nortriptyline; Polymorphism, Genetic | 2008 |
Massive intoxication involving unusual high concentration of amitriptyline.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Diazepam; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Nordazepam; Nortriptyline; Spectrometry, Mass, Electrospray Ionization; Suicide | 2007 |
Analysis of tricyclic antidepressant drugs in plasma by means of solid-phase microextraction-liquid chromatography-mass spectrometry.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Blood Chemical Analysis; Chromatography, Liquid; Clomipramine; Desipramine; Humans; Imipramine; Nortriptyline; Solid Phase Microextraction; Spectrometry, Mass, Electrospray Ionization | 2007 |
In vitro biotransformation of amitriptyline and imipramine with rat hepatic S9 fraction: evaluation of the toxicity with Spirotox and Thamnotoxkit F Tests.
Topics: Amitriptyline; Animals; Anostraca; Biotransformation; Ciliophora; Desipramine; Imipramine; Lethal Dose 50; Liver; Male; Nortriptyline; Rats; Rats, Sprague-Dawley; Toxicity Tests; Water Pollutants, Chemical | 2008 |
Assessing free and total morphine following heroin overdose when complicated by the presence of toxic amitriptyline levels.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Interactions; Drug Overdose; Fatal Outcome; Female; Forensic Toxicology; Heroin; Heroin Dependence; Humans; Injections, Intravenous; Morphine; Morphine Derivatives; Nortriptyline | 2007 |
Correlation of inter-individual variations of amitriptyline metabolism examined in hairs with CYP2C19 and CYP2D6 polymorphisms.
Topics: Alleles; Amitriptyline; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Child; Child, Preschool; Chromatography, Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Forensic Toxicology; Genotype; Hair; Humans; Mass Spectrometry; Nortriptyline; Polymorphism, Genetic | 2008 |
Uptake of amitriptyline and nortriptyline with liposomes, proteins, and serum: implications for drug detoxification.
Topics: Amitriptyline; Dimyristoylphosphatidylcholine; Humans; Liposomes; Male; Nortriptyline; Phosphatidylglycerols; Protein Binding; Proteins; Serum; Serum Albumin; Sorption Detoxification | 2008 |
An estimate of the proportion of drug-facilitation of sexual assault in four U.S. localities.
Topics: Adolescent; Adult; Ambulatory Care Facilities; Amitriptyline; Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Doxylamine; Dronabinol; Ethanol; Female; Flunitrazepam; Forensic Toxicology; Hair; Histamine H1 Antagonists; Humans; Hydromorphone; Male; Narcotics; Nortriptyline; Oxazepam; Oxycodone; Psychotropic Drugs; Sex Offenses; Substance Abuse Detection; United States | 2007 |
Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Chronic Disease; Cyclohexanecarboxylic Acids; Denervation; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Ligation; Male; Mice; Mice, Inbred C57BL; Narcotic Antagonists; Nortriptyline; Opioid Peptides; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Receptors, Opioid; Sciatic Neuropathy | 2008 |
Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Glutathione; Humans; Microsomes, Liver; Nortriptyline; Recombinant Proteins; Tandem Mass Spectrometry | 2008 |
Separation and determination of amitriptyline and nortriptyline by dispersive liquid-liquid microextraction combined with gas chromatography flame ionization detection.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Blood Chemical Analysis; Carbon Tetrachloride; Chromatography, Gas; Hydrogen-Ion Concentration; Methanol; Nortriptyline; Osmolar Concentration; Reproducibility of Results; Sensitivity and Specificity; Solvents; Water; Water Pollutants, Chemical | 2008 |
Identifying patients at risk of complete nonresponse in the outpatient treatment of depression.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Amitriptyline; Antidepressive Agents; Combined Modality Therapy; Cyclohexanols; Data Interpretation, Statistical; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Drug Resistance; Female; Humans; Male; Middle Aged; Nortriptyline; Psychotherapy; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Severity of Illness Index; Venlafaxine Hydrochloride; Young Adult | 2008 |
Pharmacokinetics of amitriptyline and one of its metabolites, nortriptyline, in rats: little contribution of considerable hepatic first-pass effect to low bioavailability of amitriptyline due to great intestinal first-pass effect.
Topics: Administration, Oral; Amitriptyline; Animals; Biological Availability; Dose-Response Relationship, Drug; Gastric Mucosa; Injections, Intravenous; Intestine, Small; Liver; Male; Nortriptyline; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2009 |
The inhibition of human neutrophil phagocytosis and oxidative burst by tricyclic antidepressants.
Topics: Amitriptyline; Anesthetics, Local; Antidepressive Agents, Tricyclic; Fluoxetine; Humans; Neutrophils; Nortriptyline; Phagocytosis; Respiratory Burst; Selective Serotonin Reuptake Inhibitors; Staphylococcus aureus | 2008 |
Evaluation of risk factors for elevated tricyclic antidepressant plasma concentrations.
Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bupropion; Case-Control Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Middle Aged; Nortriptyline; Paroxetine; Risk Factors; Selective Serotonin Reuptake Inhibitors; Sex Factors | 2009 |
Disputed case of homicide by smothering due to severe amitriptyline intoxication of the victim.
Topics: Adult; Alcoholism; Amitriptyline; Antidepressive Agents, Tricyclic; Asphyxia; Contusions; Facial Injuries; Female; Forensic Pathology; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Homicide; Humans; Nortriptyline; Purpura | 2009 |
An in vitro approach to estimate putative inhibition of buprenorphine and norbuprenorphine glucuronidation.
Topics: Amitriptyline; Buprenorphine; Central Nervous System Agents; Chromatography, Liquid; Glucuronosyltransferase; Humans; In Vitro Techniques; Lamotrigine; Liver; Mass Spectrometry; Microsomes, Liver; Narcotics; Nortriptyline; Oxazepam; Temazepam; Triazines | 2010 |
The effectiveness of tricyclic antidepressants on lumbar spinal stenosis.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Female; Humans; Low Back Pain; Lumbar Vertebrae; Male; Middle Aged; Nortriptyline; Pain Measurement; Retrospective Studies; Spinal Stenosis; Treatment Outcome | 2010 |
Tricyclic antidepressants intoxication in Tehran, Iran: epidemiology and associated factors.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Cross-Sectional Studies; Drug Overdose; Female; Humans; Iran; Male; Nortriptyline; Poisoning; Suicide, Attempted; Young Adult | 2011 |
Validated LC-MS (ESI) assay for the simultaneous determination of amitriptyline and its metabolite nortriptyline in rat plasma: application to a pharmacokinetic comparison.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Male; Nortriptyline; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization | 2010 |
Detection of amitriptyline, nortriptyline and bromazepam in liver, CSF and hair in the homicidal poisoning of a one-month-old girl autopsied 8 months after death.
Topics: Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Bromazepam; Chromatography, Liquid; Exhumation; Female; Forensic Toxicology; Hair; Homicide; Humans; Infant, Newborn; Liver; Mass Spectrometry; Nortriptyline; Poisoning | 2011 |
IFN-gamma reduction by tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cyclohexanols; Cytokines; Depressive Disorder; Desipramine; Desvenlafaxine Succinate; Female; Humans; Imipramine; In Vitro Techniques; Interferon-gamma; Male; Nortriptyline; Venlafaxine Hydrochloride | 2010 |
The effect of tricyclic antidepressants on cutaneous melanoma cell lines and primary cell cultures.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Cell Line, Tumor; Clomipramine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Melanoma; Nortriptyline; Primary Cell Culture; Skin Neoplasms | 2012 |
Detection of amitriptyline, citalopram, and metabolites in porcine bones following extended outdoor decomposition.
Topics: Amitriptyline; Animals; Antidepressive Agents; Bone and Bones; Chromatography, Liquid; Citalopram; Environment; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Nortriptyline; Postmortem Changes; Solid Phase Extraction; Swine | 2012 |
Chronic amitriptyline overdose in a child.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Child; Drug Overdose; Electrocardiography; Female; Humans; Nortriptyline; Sleep Wake Disorders; Sodium Bicarbonate; Status Epilepticus; Treatment Outcome | 2012 |
Persistence of the tricyclic antidepressant drugs amitriptyline and nortriptyline in agriculture soils.
Topics: Agriculture; Amitriptyline; Antidepressive Agents, Tricyclic; Environmental Monitoring; Models, Chemical; Nortriptyline; Soil; Soil Pollutants | 2013 |
[Amitriptyline versus placebo for major depression].
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Humans; Nortriptyline; Placebo Effect; Review Literature as Topic | 2013 |
Interpretation of pharmaceutical drug concentrations in young children's head hair.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child of Impaired Parents; Child, Preschool; Chromatography, Liquid; Female; Forensic Toxicology; Hair; Humans; Infant; Methadone; Narcotics; Nortriptyline; Pyrrolidines; Substance Abuse Detection; Tandem Mass Spectrometry; Tramadol | 2014 |
Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing.
Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Interactions; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Pain; Retrospective Studies; Sex Factors; Young Adult | 2014 |
Painful traumatic trigeminal neuropathy: an open study on the pharmacotherapeutic response to stepped treatment.
Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Baclofen; Carbamazepine; Clinical Protocols; Cohort Studies; Cyclohexanecarboxylic Acids; Drug Combinations; Duloxetine Hydrochloride; Female; Follow-Up Studies; GABA-B Receptor Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Medical Records; Middle Aged; Nortriptyline; Pain; Pain Measurement; Pregabalin; Prognosis; Prospective Studies; Thiophenes; Treatment Outcome; Trigeminal Nerve Injuries; Trigeminal Neuralgia | 2014 |
An electronic health records study of long-term weight gain following antidepressant use.
Topics: Adult; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Body Mass Index; Bupropion; Citalopram; Electronic Health Records; Female; Humans; Male; Middle Aged; New England; Nortriptyline; Prospective Studies; Weight Gain; Young Adult | 2014 |
Use of tricyclic antidepressants as analgesic adjuvants results in nonhazardous prolongation of the QTc interval.
Topics: Aged; Aged, 80 and over; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Electrocardiography; Female; Herpes Zoster; Humans; Hypertrophy, Left Ventricular; Japan; Logistic Models; Long QT Syndrome; Male; Middle Aged; Multivariate Analysis; Neuralgia, Postherpetic; Nortriptyline; Odds Ratio; Pain Measurement; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors | 2014 |
A simple dried blood spot method for therapeutic drug monitoring of the tricyclic antidepressants amitriptyline, nortriptyline, imipramine, clomipramine, and their active metabolites using LC-MS/MS.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biotransformation; Calibration; Chromatography, Liquid; Clomipramine; Depressive Disorder, Major; Dried Blood Spot Testing; Drug Monitoring; Hematocrit; Humans; Imipramine; Limit of Detection; Nortriptyline; Reproducibility of Results; Tandem Mass Spectrometry | 2015 |
Dose equivalents of antidepressants: Evidence-based recommendations from randomized controlled trials.
Topics: Adult; Amitriptyline; Antidepressive Agents; Bupropion; Citalopram; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Evidence-Based Medicine; Female; Fluoxetine; Fluvoxamine; Humans; Male; Middle Aged; Moclobemide; Nortriptyline; Paroxetine; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Sertraline; Treatment Outcome | 2015 |
Tricyclic antidepressants for the treatment of tenesmus associated with rectal prolapse.
Topics: Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Defecation; Desipramine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nortriptyline; Rectal Diseases; Rectal Prolapse; Retrospective Studies; Treatment Outcome | 2015 |
Dynamic electromembrane extraction: Automated movement of donor and acceptor phases to improve extraction efficiency.
Topics: Amitriptyline; Electrochemical Techniques; Limit of Detection; Liquid-Liquid Extraction; Membranes, Artificial; Nortriptyline; Reproducibility of Results; Solutions; Solvents | 2015 |
Quantification of Tricyclic Antidepressants in Serum Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS).
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Humans; Imipramine; Nortriptyline; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2016 |
A novel strategy for spectrophotometric simultaneous determination of amitriptyline and nortriptyline based on derivation with a quinonoid compound in serum samples.
Topics: Acetaldehyde; Amitriptyline; Benzoquinones; Calibration; Chloranil; Humans; Hydrogen-Ion Concentration; Ionic Liquids; Limit of Detection; Nanoparticles; Nortriptyline; Reproducibility of Results; Solid Phase Extraction; Spectrophotometry, Ultraviolet; Time Factors | 2016 |
Limitations of the Anticholinergic Activity Assay and Assay-Based Anticholinergic Drug Scales.
Topics: Amitriptyline; Cholinergic Antagonists; Cognitive Dysfunction; Diphenhydramine; Dose-Response Relationship, Drug; Drug Interactions; Furosemide; Humans; Nortriptyline; Pilocarpine; Radioligand Assay; Thioridazine | 2016 |
Analysis of the Mechanism of Prolonged Persistence of Drug Interaction between Terbinafine and Amitriptyline or Nortriptyline.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Drug Interactions; Enzyme Inhibitors; Humans; Microsomes, Liver; Naphthalenes; Nortriptyline; Terbinafine | 2017 |
Photosensitized Degradation of Amitriptyline and Its Active Metabolite Nortriptyline in Aqueous Fulvic Acid Solution.
Topics: Amitriptyline; Benzopyrans; Hydrogen-Ion Concentration; Kinetics; Nortriptyline; Photolysis; Solutions; Sunlight; Water Pollutants, Chemical | 2017 |
Investigation of pH effect on cationic solute binding to keratin and partition to hair.
Topics: Amitriptyline; Cations; Hair; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Keratins; Microscopy, Electron, Transmission; Nortriptyline; Protein Binding; Spectrometry, Fluorescence; Theophylline; Thermodynamics | 2018 |
Mechanistic Physiologically Based Pharmacokinetic (PBPK) Model of the Heart Accounting for Inter-Individual Variability: Development and Performance Verification.
Topics: Amitriptyline; Biological Variation, Population; Heart; Humans; Models, Biological; Nortriptyline; Tissue Distribution | 2018 |
Suitability of 1-hexyl-3-methylimidazolium ionic liquids for the analysis of pharmaceutical formulations containing tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Borates; Chromatography, Reverse-Phase; Doxepin; Drug Compounding; Imidazoles; Ionic Liquids; Limit of Detection; Nortriptyline; Spectrophotometry, Ultraviolet | 2018 |
Short- and Long-term Effects of Neuromodulators for Unexplained Chronic Cough.
Topics: Adult; Aged; Amitriptyline; Chronic Disease; Cohort Studies; Cough; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Gabapentin; Humans; Linear Models; Male; Middle Aged; Neurotransmitter Agents; Nortriptyline; Prospective Studies; Risk Assessment; Surveys and Questionnaires; Tertiary Care Centers; Time Factors; Treatment Outcome | 2018 |
Nortriptyline safer than amitriptyline?
Topics: Amitriptyline; Canada; Consensus; Humans; Neuralgia; Nortriptyline | 2018 |
Quantitative Modeling Analysis Demonstrates the Impact of CYP2C19 and CYP2D6 Genetic Polymorphisms on the Pharmacokinetics of Amitriptyline and Its Metabolite, Nortriptyline.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Genotype; Humans; Male; Models, Biological; Nortriptyline; Polymorphism, Genetic; Tandem Mass Spectrometry; Young Adult | 2019 |
Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Clozapine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Desvenlafaxine Succinate; Doxepin; Drug Monitoring; Female; Glucuronosyltransferase; Humans; Male; Middle Aged; Mirtazapine; Nortriptyline; Paliperidone Palmitate; Quetiapine Fumarate; Retrospective Studies; Risperidone; Smoking; Venlafaxine Hydrochloride | 2019 |
A rapid and simple extraction of anti-depressant drugs by effervescent salt-assisted dispersive magnetic micro solid-phase extraction method using new adsorbent Fe
Topics: Adsorption; Amitriptyline; Azides; Humans; Limit of Detection; Magnetite Nanoparticles; Nortriptyline; Silicon Dioxide; Solid Phase Microextraction; Wastewater | 2019 |
Carbon monoxide releasing molecule 401 (CORM-401) modulates phase I metabolism of xenobiotics.
Topics: Amitriptyline; Carbon Monoxide; Cytochrome P-450 Enzyme System; Hep G2 Cells; Humans; N-substituted Glycines; Nortriptyline; Xenobiotics | 2019 |
Amitriptyline accumulation in tissues after coated activated charcoal hemoperfusion-a randomized controlled animal poisoning model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antidotes; Charcoal; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Hemoperfusion; Nortriptyline; Swine; Tandem Mass Spectrometry; Tissue Distribution | 2019 |
Experimental and Clinical Pharmacokinetics of Fluoxetine and Amitriptyline: Comparative Analysis and Possible Methods of Extrapolation.
Topics: Administration, Oral; Amitriptyline; Animals; Biological Availability; Dogs; Female; Fluoxetine; Humans; Male; Nortriptyline | 2019 |
Commutability of proficiency testing material containing amitriptyline and nortriptyline: A study within the framework of the Dutch Calibration 2.000 project.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cattle; Freeze Drying; Humans; Laboratories; Laboratory Proficiency Testing; Linear Models; Nortriptyline; Quality Control | 2019 |
Storage of urine specimens in point of care (POC) urine drug testing cups reduces concentrations of many drugs.
Topics: Amitriptyline; Chromatography, Liquid; Drug Storage; Fentanyl; Flunitrazepam; Fluoxetine; Humans; Mass Spectrometry; Nortriptyline; Paroxetine; Point-of-Care Testing; Sertraline | 2019 |
Nortriptyline serum concentration as a predictor for cardiac risk in amitriptyline-treated patients.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Atrioventricular Block; Bundle-Branch Block; Doxepin; Electrocardiography; Female; Heart; Heart Function Tests; Humans; Male; Middle Aged; Nortriptyline; Retrospective Studies; Risk Factors | 2020 |
β-Cyclodextrin encapsulation of nortriptyline HCl and amitriptyline HCl: Molecular insights from single-crystal X-ray diffraction and DFT calculation.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; beta-Cyclodextrins; Crystallography, X-Ray; Density Functional Theory; Drug Stability; Nortriptyline; X-Ray Diffraction | 2020 |
An investigation into the modulation of T cell phenotypes by amitriptyline and nortriptyline.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; CD8-Positive T-Lymphocytes; Cell Death; Cytokines; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Nortriptyline; Phenotype; T-Lymphocytes | 2020 |
Supramolecular microextraction combined with paper spray ionization mass spectrometry for sensitive determination of tricyclic antidepressants in urine.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Doxepin; Humans; Imipramine; Liquid Phase Microextraction; Macromolecular Substances; Mass Spectrometry; Molecular Structure; Nortriptyline; Paper | 2020 |
Electrochemical sensor for tricyclic antidepressants with low nanomolar detection limit: Quantitative Determination of Amitriptyline and Nortriptyline in blood.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Limit of Detection; Nortriptyline | 2022 |
The interplay between pharmacogenetics, concomitant drugs and blood levels of amitriptyline and its main metabolites.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Humans; Nortriptyline; Pharmacogenetics | 2022 |
Effects of the LC mobile phase in vacuum differential mobility spectrometry-mass spectrometry for the selective analysis of antidepressant drugs in human plasma.
Topics: Acetonitriles; Amitriptyline; Antidepressive Agents; Desipramine; Humans; Imipramine; Maprotiline; Mass Spectrometry; Methanol; Nortriptyline; Reproducibility of Results; Spectrum Analysis; Vacuum; Venlafaxine Hydrochloride | 2022 |
Effect of Information Intervention on Prescribing Practice for Neuropathic Pain in Older Patients: A Nationwide Register-Based Study.
Topics: Aged; Amitriptyline; Drug-Related Side Effects and Adverse Reactions; Humans; Inappropriate Prescribing; Neuralgia; Nortriptyline; Practice Patterns, Physicians'; Pregabalin | 2023 |
On-Chip Electromembrane Surrounded Solid Phase Microextraction for Determination of Tricyclic Antidepressants from Biological Fluids Using Poly(3,4-ethylenedioxythiophene)-Graphene Oxide Nanocomposite as a Fiber Coating.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Humans; Imipramine; Limit of Detection; Maprotiline; Nanocomposites; Nortriptyline; Reproducibility of Results; Sertraline; Solid Phase Microextraction | 2023 |
Growth of bimetallic Ni-Co MOFs on a skeleton of electrospun PAN nanofibers and coating on a thin film for SPME of amitriptyline and nortriptyline in urine and plasma samples.
Topics: Amitriptyline; Limit of Detection; Nanofibers; Nortriptyline; Reproducibility of Results; Skeleton; Solid Phase Microextraction | 2023 |