amitriptyline and morphine

amitriptyline has been researched along with morphine in 96 studies

Research

Studies (96)

Timeframe	Studies, this research(%)	All Research%
pre-1990	28 (29.17)	18.7374
1990's	12 (12.50)	18.2507
2000's	29 (30.21)	29.6817
2010's	27 (28.13)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Strassburg, CP; Tukey, RH	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Chang, TK; Ensom, MH; Kiang, TK	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Goldstein, FJ; Malseed, RT	1
Cravey, RH; Garriott, JC; Lundberg, GD; Reynolds, PC; Shaw, RF	1
Fujimoto, S; Hisada, S	1
Cuparencu, B; Sandor, V	1
Gastmeier, K; Hass, M; Kuteifan, K; Schott, H	1
Blanchi, M; De Conno, F; Panerai, AE; Ripamonti, C; Sacerdote, P; Ventafridda, V; Zecca, E	1
Odar-Cederlöf, I; Säwe, J; von Bahr, C; Yue, Q	1
Benoliel, JJ; Bourgoin, S; Cesselin, F; Gozlan, H; Hamon, M; Mauborgne, A; Mico, JA; Taquet, H	1
Besson, JM; Butler, SH; Godefroy, F; Weil-Fugazza, J	1
Adithan, C; Bapna, JS; Raveendran, R; Sivagnanam, G	1
Gordon, NC; Levine, JD; McBryde, R; Smith, R	1
Yamamoto, J	1
Fabian, A; Fields, HL; Pazoles, CJ; Taiwo, YO	1
Cadden, JJ; Feigelson, EB	1
Greengard, P; Quinn, GP; Reid, MB	1
Hartmann, E	1
Kaniike, K; Kurogochi, Y	1
Cater, BR; Chapman, D; Hawes, SM; Saville, J	1
Kaneto, H; Koida, M; Tsuchie, F	1
Kaneto, H; Koida, M; Miyagawa, H; Tsuchie, F	1
Mattila, MJ; Saarnivaara, L	1
Wuttke, W	1
Senault, B	1
Charest, MP; Davis, MA; Herr, F; Thomas, RA	1
Botney, M; Fields, HL	1
Arnt, J; Larsen, JJ	1
Novack, GD; Zwolshen, JM	1
Wassermann, K	1
Liu, SJ; Wang, RI	1
Eisenach, JC; Gebhart, GF	2
Finley, GA; Gordon, KE; Ludman, MD	1
Cerda, SE; Deal, DD; Eisenach, JC; Tong, C	1
Ardid, D; Chapuy, E; Eschalier, A; Jourdan, D; Le Bars, D	1
Hashimoto, Y; Moriya, F	1
Field, MJ; Hughes, J; McCleary, S; Singh, L	1
Onal, A; Tuğlular, I	1
Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I	1
Alvarez López, JC; González De Zárate, J; Herrero Gento, E	1
ASKEW, BM	1
Dallel, R; Dégoulange, C; Gaydier, AM; Luccarini, P; Perrier, L	1
Bessis, D; Guilhou, JJ; Guillot, B; Legouffe, E	1
De Vry, J; Jentzsch, KR	1
Bonnet, U; Overlack, M; Schürks, M	1
Miki, S; Senba, E; Yasuda, T; Yoshinaga, N	1
Tai, YH; Tao, PL; Tung, CS; Wang, JJ; Wang, YH; Wong, CS	1
Liu, TM; Tai, YH; Tao, PL; Tsai, RY; Wang, JJ; Wang, YC; Wang, YH; Wong, CS	1
Fick, LG; Loram, LC; Mitchell, D; Skosana, M	1
Cheevers, CV; Donello, JE; Gil, DW	1
Avella, J; Katz, M; Lehrer, M	1
Coderre, TJ; Millecamps, M	1
Cherng, CH; Liu, TM; Tai, YH; Tao, PL; Tsai, RY; Wang, YH; Wong, CS	1
Cherng, CH; Lee, MS; Lin, JA; Lin, YT; Tsai, RY; Tzeng, JI; Wong, CS	1
Garcia-Bournissen, F; Hoshino, N; Ito, S; Kapur, B; Koren, G; Kozer, E; Leombruno, J; Levichek, Z; Taguchi, N	1
Lin, SL; Tai, YH; Tao, PL; Tsai, RY; Wang, JJ; Wong, CS; Yeh, CC	1
Pettersen, VL; Raimundo, JM; Sudo, RT; Trachez, MM; Zapata-Sudo, G	1
Furuta, S; Horie, S; Kuzumaki, N; Matsumoto, K; Narita, M; Shimizu, T; Suzuki, T	1
Baran, E; Enginar, N; Karamürsel, Y; Nurten, A; Zengin, A	1
Densmore, VS; Kalous, A; Keast, JR; Osborne, PB	1
Bhatnagar, S; Goyal, GN; Mishra, S; Rana, SP; Upadhya, SP	1
Buldum, D; Gunduz, O; Guven, R; Oltulu, C; Ulugol, A	1
Cherng, CH; Chien, CC; Huang, YN; Lin, SL; Tsai, RY; Wong, CS; Wu, CT; Yeh, CC	1
Bagcivan, I; Gursoy, S; Ozdemir, E	1
Chen, ACh; Chen, CH; Chen, YT; Fang, CP; Ho, IK; Hsiao, CF; Hsu, YT; Huang, CL; Kuo, HW; Lin, L; Liu, CT; Liu, ML; Liu, SC; Liu, YL; Shih, YH; Su, LW; Tan, HK; Tian, JN; Tsou, HH; Wu, CS; Yang, YH; Yang, YT	1
Aoki, T; Enomoto, R; Matsuoka, N; Shimoshige, Y; Tsukamoto, M	1
Bernardy, CC; Calixto-Campos, C; Cardoso, RD; Casagrande, R; Cecchini, R; Corrêa, M; Crespigio, J; Moreira, EG; Pinho-Ribeiro, FA; Verri, WA; Zarpelon, AC	1
Jagla, G; Makuch, W; Mika, J; Obara, I; Przewlocka, B; Wordliczek, J	1
Khan, N; Smith, MT; Woodruff, TM	1
Antonio, CB; da Costa, PF; Müller, LG; Noël, F; Rates, SM; Stolz, ED; von Poser, GL	1
Bidaghi, A; Ghanbarzadeh, S; Habibi-Asl, B; Najafi, M; Vaez, H	1
Aldington, D; Derry, S; Moore, RA; Wiffen, PJ	1
Cai, Z; He, GD; Lin, H; Pi, ZB; Xu, XZ	1
Dogishi, K; Kaneko, S; Kodera, M; Nakagawa, T; Oyama, S; Shirakawa, H	1
Akbari, E; Haghparast, A; Mirzaei, E; Rezaee, L; Zarrabian, S	1
Guo, D; Guo, J; Huang, S; Li, Q; Polli, JE; Shu, Y; Xiong, Z; Ye, Z; Zhang, W; Zhou, H; Zhu, P	1
Lin, Z; Ouyang, Z; Ren, Y; Zhang, W	1
Bryniarski, K; Filipczak-Bryniarska, I; Kozlowski, M; Nazimek, K; Nowak, B	1

Reviews

5 review(s) available for amitriptyline and morphine

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Pharmacological studies of sleep and dreaming: chemical and clinical relationships. Biological psychiatry, 1969, Volume: 1, Issue:3 Topics: Amitriptyline; Amphetamine; Antidepressive Agents; Atropine; Chloralose; Chlordiazepoxide; Chlorpromazine; Desipramine; Dextroamphetamine; Diazepam; Diphenhydramine; Dreams; Glutethimide; Humans; Hypnotics and Sedatives; Imipramine; Lysergic Acid Diethylamide; Meprobamate; Methaqualone; Morphine; Nialamide; Pentobarbital; Reserpine; Sleep; Sleep, REM; Tranquilizing Agents; Tranylcypromine; Triiodothyronine; Tryptophan	1969
Nortriptyline for neuropathic pain in adults. The Cochrane database of systematic reviews, 2015, Jan-08, Volume: 1 Topics: Amines; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Clomipramine; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Middle Aged; Morphine; Neuralgia; Nortriptyline; Pregabalin; Randomized Controlled Trials as Topic	2015

Trials

3 trial(s) available for amitriptyline and morphine

Article	Year
Desipramine enhances opiate postoperative analgesia. Pain, 1986, Volume: 27, Issue:1 Topics: Amitriptyline; Analgesia; Desipramine; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Humans; Morphine; Pain Measurement; Pain, Postoperative; Postoperative Period; Preanesthetic Medication; Time Factors	1986
A comparative efficacy of amitriptyline, gabapentin, and pregabalin in neuropathic cancer pain: a prospective randomized double-blind placebo-controlled study. The American journal of hospice & palliative care, 2012, Volume: 29, Issue:3 Topics: Adult; Amines; Amitriptyline; Analgesics; Analysis of Variance; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Therapy, Combination; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Morphine; Neoplasms; Neuralgia; Pain Measurement; Pregabalin; Prospective Studies	2012
Randomized and controlled prospective trials of Ultrasound-guided spinal nerve posterior ramus pulsed radiofrequency treatment for lower back post-herpetic neuralgia. La Clinica terapeutica, 2015, Volume: 166, Issue:5 Topics: Administration, Oral; Adult; Aged; Amines; Amitriptyline; Analgesics; Celecoxib; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Low Back Pain; Male; Middle Aged; Morphine; Neuralgia, Postherpetic; Pain Measurement; Prospective Studies; Pulsed Radiofrequency Treatment; Sleep; Spinal Nerves	2015

Other Studies

88 other study(ies) available for amitriptyline and morphine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. Journal of medicinal chemistry, 2009, Oct-22, Volume: 52, Issue:20 Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Enhancement of morphine analgesia by tricyclic antidepressants. Neuropharmacology, 1979, Volume: 18, Issue:10 Topics: Amitriptyline; Analgesia; Animals; Antidepressive Agents, Tricyclic; Cats; Drug Synergism; Male; Morphine; Nortriptyline; Reaction Time; Time Factors	1979
Cocaine-related death. Journal of forensic sciences, 1977, Volume: 22, Issue:2 Topics: Adolescent; Adult; Amitriptyline; Amphetamines; Brain Edema; Cocaine; Ethanol; Female; Forensic Medicine; Humans; Intracranial Aneurysm; Lidocaine; Male; Morphine; Nortriptyline; Phenmetrazine; Substance-Related Disorders; Suicide; Tissue Distribution	1977
Effects of centrally affecting drugs on the diuretic and antidiuretic actions of intracerebroventricular prostaglandin E2. Japanese journal of pharmacology, 1978, Volume: 28, Issue:1 Topics: Amitriptyline; Animals; Central Nervous System; Diazepam; Diuresis; Drug Interactions; gamma-Aminobutyric Acid; Injections, Intraventricular; Morphine; Norepinephrine; Pentobarbital; Prostaglandins E; Rats; Reserpine; Time Factors	1978
Analysis of the mechanism of the protective activity of some sympathomimetic amines in experimental ulcers. Pharmacology, 1977, Volume: 15, Issue:3 Topics: Amitriptyline; Amphetamine; Animals; Apomorphine; Butyrophenones; Catecholamines; Chlorpromazine; Cocaine; Levodopa; Morphine; Pimozide; Rats; Receptors, Adrenergic; Reserpine; Restraint, Physical; Stomach Ulcer; Sympathomimetics; Trifluperidol	1977
[Pain therapy for urologic cancer patients at the Potsdam district hospital--initial results]. Zeitschrift fur Urologie und Nephrologie, 1990, Volume: 83, Issue:10 Topics: Aged; Amitriptyline; Analgesics; Analgesics, Opioid; Aspirin; Carbamazepine; Codeine; Dipyrone; Drug Therapy, Combination; Haloperidol; Humans; Imipramine; Indomethacin; Meperidine; Morphine; Pain; Pain Measurement; Prospective Studies; Urologic Neoplasms	1990
Studies on the effects of antidepressant drugs on the antinociceptive action of morphine and on plasma morphine in rat and man. Pain, 1990, Volume: 43, Issue:2 Topics: Amitriptyline; Analgesia; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Drug Synergism; Humans; Morphine; Nortriptyline; Rats; Rats, Inbred Strains; Trazodone	1990
Glucuronidation of codeine and morphine in human liver and kidney microsomes: effect of inhibitors. Pharmacology & toxicology, 1990, Volume: 66, Issue:3 Topics: Adult; Amitriptyline; Chloramphenicol; Codeine; Diazepam; Glucuronates; Glucuronosyltransferase; Humans; In Vitro Techniques; Kidney; Kinetics; Microsomes; Microsomes, Liver; Morphine; Oxazepam; Probenecid	1990
Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline. Neuropharmacology, 1987, Volume: 26, Issue:6 Topics: Amitriptyline; Amoxapine; Animals; Antidepressive Agents, Tricyclic; Central Nervous System; Cerebral Cortex; Drug Synergism; Hypothalamus; Male; Morphine; Neuropeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Serotonin; Spinal Cord	1987
Do acute or chronic tricyclic antidepressants modify morphine antinociception in arthritic rats? Pain, 1986, Volume: 25, Issue:2 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arthritis; Arthritis, Experimental; Drug Synergism; Drug Therapy, Combination; Imipramine; Male; Morphine; Nociceptors; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Vocalization, Animal	1986
Amitriptyline analgesia: tolerance & cross tolerance pattern. The Indian journal of medical research, 1986, Volume: 84 Topics: Amitriptyline; Analgesia; Analgesics; Animals; Clonidine; Drug Tolerance; Male; Mice; Morphine	1986
Characteristics of the cortical and hippocampal EEG power spectra of rabbits during normal behavioral states and after administration of CNS acting drugs. Japanese journal of pharmacology, 1985, Volume: 37, Issue:3 Topics: Amitriptyline; Animals; Behavior, Animal; Central Nervous System Agents; Cerebral Cortex; Chlorpromazine; Diazepam; Electroencephalography; Hippocampus; Male; Morphine; Motor Cortex; Pentobarbital; Rabbits; Time Factors	1985
Potentiation of morphine antinociception by monoamine reuptake inhibitors in the rat spinal cord. Pain, 1985, Volume: 21, Issue:4 Topics: 1-Naphthylamine; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Drug Synergism; Male; Morphine; Nociceptors; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Sertraline; Spinal Cord	1985
Changing patterns of drug abuse in New York City. The American journal of drug and alcohol abuse, 1974, Volume: 1, Issue:3 Topics: Adolescent; Adult; Amitriptyline; Amphetamines; Antipsychotic Agents; Barbiturates; Codeine; Dextropropoxyphene; Female; Glutethimide; Heroin Dependence; Humans; Male; Methadone; Morphine; New York City; Phenothiazines; Phenytoin; Quinine; Substance-Related Disorders	1974
Prevention by antidepressant drugs of reserpine effect on pyridine nucleotide metabolism. Molecular pharmacology, 1966, Volume: 2, Issue:4 Topics: Aminopyrine; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Atropine; Benactyzine; Caffeine; Chlorpheniramine; Chlorpromazine; Female; Hexobarbital; Hydralazine; Hypothalamus; Imipramine; Iproniazid; Isoniazid; Liver; Meprobamate; Methacholine Compounds; Morphine; NAD; Niacinamide; Pargyline; Pentobarbital; Phenylbutazone; Phenytoin; Quinacrine; Rats; Reserpine; Tranylcypromine; Tripelennamine; Zoxazolamine	1966
[Effect of psychotropic drugs on the K + -dependent phosphatase activity in guinea pig brain microsomes]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1972, Volume: 68, Issue:1 Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Chlordiazepoxide; Chlorpromazine; Desipramine; Diazepam; Guinea Pigs; Histamine; Hydroxyzine; Imipramine; Meprobamate; Microsomes; Morphine; Nialamide; Phenelzine; Phenobarbital; Phenoxybenzamine; Phosphoric Monoester Hydrolases; Pilocarpine; Potassium; Procaine; Reserpine; Tranquilizing Agents	1972
Lipid phase transitions and drug interactions. Biochimica et biophysica acta, 1974, Aug-21, Volume: 363, Issue:1 Topics: Amitriptyline; Binding Sites; Calorimetry; Desipramine; Electron Spin Resonance Spectroscopy; Imipramine; Kinetics; Magnetic Resonance Spectroscopy; Membranes, Artificial; Models, Biological; Molecular Conformation; Morphinans; Morphine; Nortriptyline; Palmitic Acids; Phosphatidylcholines; Structure-Activity Relationship; Temperature; Thermodynamics	1974
[Tolerance and physical dependence producing liability of doxepin]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1972, Volume: 68, Issue:6 Topics: Amitriptyline; Animals; Body Weight; Diazepam; Dibenzoxepins; Drug Resistance; Humans; Imipramine; Male; Mice; Morphine; Motor Activity; Phenobarbital; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders	1972
[Screening procedure for barbital type physical dependence liability of psychotropic drugs in mice]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1973, Volume: 69, Issue:5 Topics: Amitriptyline; Animals; Barbiturates; Behavior, Animal; Benzazepines; Benzodiazepinones; Body Weight; Carboxylic Acids; Chlordiazepoxide; Chlorpromazine; Diazepam; Doxepin; Dronabinol; Humans; Imines; Isoquinolines; Male; Mice; Morphine; Nitrazepam; Oxazoles; Substance Withdrawal Syndrome; Substance-Related Disorders; Tranquilizing Agents	1973
Comparison of tricyclic antidepressants in rabbits: antinociception and potentiation of the noradrenaline pressor responses. Psychopharmacologia, 1974, Feb-27, Volume: 35, Issue:3 Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Aorta; Blood Pressure; Chlorpromazine; Desipramine; Dibenzazepines; Dose-Response Relationship, Drug; Doxepin; Drug Synergism; Imipramine; In Vitro Techniques; Iprindole; Lithium; Morphine; Norepinephrine; Nortriptyline; Opipramol; Rabbits; Succinimides; Time Factors	1974
[The effect of psychotropic drugs on the spontaneous behavior of the cat]. Arzneimittel-Forschung, 1971, Volume: 21, Issue:12 Topics: Amitriptyline; Animals; Attention; Behavior, Animal; Cats; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Emotions; Female; Morphine; Motor Activity; Scopolamine; Social Behavior	1971
[Intraspecific aggressive behavior induced by apomorphine in the rat]. Psychopharmacologia, 1970, Volume: 18, Issue:3 Topics: Acepromazine; Age Factors; Aggression; Amitriptyline; Animals; Apomorphine; Atropine; Behavior, Animal; Caffeine; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Diazepam; Drug Antagonism; Electroshock; Environment; Haloperidol; Humans; Hydroxyzine; Imipramine; Male; Meprobamate; Morphine; Rats; Reserpine; Sex Factors; Sound; Species Specificity; Thiazines; Thioridazine	1970
New psychotropic agents. 8. Analogs of amitriptyline containing the normeperidine group. Journal of medicinal chemistry, 1967, Volume: 10, Issue:4 Topics: Amitriptyline; Animals; Behavior, Animal; Chemistry, Organic; Eye; Fasting; Gastrointestinal Motility; Meperidine; Mice; Morphine; Organic Chemistry Phenomena	1967
Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system. Annals of neurology, 1983, Volume: 13, Issue:2 Topics: Amitriptyline; Analgesia; Animals; Central Nervous System; Drug Synergism; Female; Fenclonine; Morphine; Rats; Rats, Inbred Strains; Reaction Time; Reflex; Tail	1983
Spinal 5-HT or NA uptake inhibition potentiates supraspinal morphine antinociception in rats. Acta pharmacologica et toxicologica, 1984, Volume: 54, Issue:1 Topics: Amitriptyline; Animals; Central Nervous System; Citalopram; Desipramine; Drug Synergism; Injections, Intraventricular; Male; Morphine; Neural Pathways; Norepinephrine; Propylamines; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord	1984
Predictive value of muscle relaxant models in rats and cats. Journal of pharmacological methods, 1983, Volume: 10, Issue:3 Topics: Amitriptyline; Animals; Benzodiazepines; Cats; Female; Male; Models, Biological; Morphine; Muscle Relaxants, Central; Rats; Rats, Inbred Strains; Reflex	1983
Pharmacological screening of the nude mouse with respect to some neuroactive drugs. Acta pharmacologica et toxicologica, 1983, Volume: 52, Issue:2 Topics: Amitriptyline; Analgesics; Animals; Anticonvulsants; Antidepressive Agents; Apomorphine; Drug Evaluation, Preclinical; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Morphine; Nervous System; Stereotyped Behavior	1983
Increased sensitivity of the central nervous system to morphine analgesia by amitriptyline in naive and morphine-tolerant rats. Biochemical pharmacology, 1981, Aug-01, Volume: 30, Issue:15 Topics: Amitriptyline; Analgesics; Animals; Brain; Central Nervous System; Drug Interactions; Drug Tolerance; Male; Morphine; Rats; Rats, Inbred Strains; Tissue Distribution	1981
Intrathecal amitriptyline. Antinociceptive interactions with intravenous morphine and intrathecal clonidine, neostigmine, and carbamylcholine in rats. Anesthesiology, 1995, Volume: 83, Issue:5 Topics: Adrenergic Agents; Amitriptyline; Analgesia; Analgesics, Opioid; Animals; Carbachol; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intravenous; Injections, Spinal; Male; Morphine; Neostigmine; Parasympathomimetics; Rats; Rats, Sprague-Dawley	1995
Intrathecal amitriptyline acts as an N-methyl-D-aspartate receptor antagonist in the presence of inflammatory hyperalgesia in rats. Anesthesiology, 1995, Volume: 83, Issue:5 Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics, Opioid; Animals; Behavior, Animal; Carrageenan; Drug Interactions; Drug Therapy, Combination; Excipients; Hyperalgesia; Injections, Intravenous; Injections, Spinal; Male; Methysergide; Morphine; Phentolamine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin Antagonists	1995
Successful treatment of painful crises of Fabry disease with low dose morphine. Pediatric neurology, 1995, Volume: 12, Issue:3 Topics: Amitriptyline; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Fabry Disease; Humans; Infusions, Intravenous; Male; Morphine; Pain; Pain Measurement; Paresthesia	1995
A physiologic assessment of intrathecal amitriptyline in sheep. Anesthesiology, 1997, Volume: 86, Issue:5 Topics: Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Catecholamines; Dose-Response Relationship, Drug; Female; Hemodynamics; Injections, Spinal; Morphine; Pain Measurement; Regional Blood Flow; Sheep; Spinal Cord	1997
Drugs for pain. The Medical letter on drugs and therapeutics, 1998, Aug-14, Volume: 40, Issue:1033 Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Aspirin; Constipation; Diabetic Neuropathies; Dose-Response Relationship, Drug; Drug Tolerance; Half-Life; Humans; Injections, Intramuscular; Injections, Intravenous; Ketorolac; Levorphanol; Meperidine; Methadone; Morphine; Narcotic Antagonists; Narcotics; Pain; Tolmetin; Tramadol	1998
Effect of analgesics on audible and ultrasonic pain-induced vocalization in the rat. Life sciences, 1998, Volume: 63, Issue:20 Topics: Amitriptyline; Analgesics; Animals; Aspirin; Cricetinae; Electric Stimulation; Male; Morphine; Naloxone; Pain; Rats; Rats, Sprague-Dawley; Ultrasonics; Vocalization, Animal	1998
Redistribution of basic drugs into cardiac blood from surrounding tissues during early-stages postmortem. Journal of forensic sciences, 1999, Volume: 44, Issue:1 Topics: Adult; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Autopsy; Central Nervous System Stimulants; Chromatography, Gas; Coronary Circulation; Drug Overdose; Female; Gas Chromatography-Mass Spectrometry; Histamine H1 Antagonists; Humans; Illicit Drugs; Male; Methamphetamine; Middle Aged; Morphine; Narcotics; Nortriptyline; Postmortem Changes; Promethazine; Rabbits; Tissue Distribution	1999
Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat. Pain, 1999, Volume: 80, Issue:1-2 Topics: Acetates; Amines; Amitriptyline; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Gabapentin; gamma-Aminobutyric Acid; Hindlimb; Hyperglycemia; Injections; Injections, Spinal; Male; Morphine; Pain; Physical Stimulation; Pregabalin; Rats; Rats, Sprague-Dawley; Skin; Streptozocin; Touch	1999
The relationship between pupil diameter and pain by the administration of morphine and antidepressant drugs in mice. General pharmacology, 1999, Volume: 33, Issue:1 Topics: Amitriptyline; Analgesia; Analgesics, Opioid; Animals; Antidepressive Agents; Desipramine; Male; Mice; Morphine; Mydriasis; Pain; Pain Measurement; Pain Threshold; Pupil; Sertraline; Time Factors	1999
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. Japanese journal of pharmacology, 2000, Volume: 83, Issue:4 Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents, Tricyclic; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Female; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Herpes Simplex; Herpesvirus 1, Human; Hyperalgesia; Mice; Mice, Inbred BALB C; Morphine; Neuralgia; Neurons, Afferent; Pain	2000
[Treatment of pain in a case of osteogenesis imperfecta type III]. Anales espanoles de pediatria, 2002, Volume: 57, Issue:3 Topics: Adolescent; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Drug Therapy, Combination; Female; Humans; Morphine; Narcotics; Osteogenesis Imperfecta; Pain; Radiography; Severity of Illness Index; Tramadol	2002
A SIMPLE SCREENING PROCEDURE FOR IMIPRAMINE-LIKE ANTIDEPRESSANT AGENTS. Life sciences (1962), 1963, Volume: 10 Topics: 5-Hydroxytryptophan; Amitriptyline; Amphetamine; Amphetamines; Antidepressive Agents; Atropine; Bemegride; Chlorpromazine; Diethylpropion; Dihydroxyphenylalanine; Epinephrine; Hypothermia; Hypothermia, Induced; Imipramine; Indoles; Iproniazid; Lysergic Acid Diethylamide; Mice; Morphine; Nialamide; Pentylenetetrazole; Pharmacology; Phenelzine; Promethazine; Research; Reserpine	1963
Synergistic antinociceptive effect of amitriptyline and morphine in the rat orofacial formalin test. Anesthesiology, 2004, Volume: 100, Issue:3 Topics: Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents; Dose-Response Relationship, Drug; Drug Synergism; Facial Pain; Formaldehyde; Male; Morphine; Motor Activity; Pain Measurement; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reaction Time	2004
Gemcitabine-associated scleroderma-like changes of the lower extremities. Journal of the American Academy of Dermatology, 2004, Volume: 51, Issue:2 Suppl Topics: Acetaminophen; Amitriptyline; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Neoplasms; Carcinoma, Transitional Cell; Cisplatin; Clonazepam; Deoxycytidine; Dermis; Doxorubicin; Edema; Gemcitabine; Humans; Infusions, Intravenous; Leg; Lung Neoplasms; Male; Methotrexate; Middle Aged; Morphine; Scleroderma, Diffuse; Vinblastine	2004
Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat. European journal of pharmacology, 2004, Nov-28, Volume: 505, Issue:1-3 Topics: Alkanesulfonates; Amines; Amitriptyline; Animals; Baclofen; Behavior, Animal; Benzoxazines; Carbamazepine; Cyclohexanecarboxylic Acids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Gabapentin; gamma-Aminobutyric Acid; Indans; Male; Molecular Structure; Morphine; Morpholines; Naphthalenes; Nitriles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sulfonic Acids	2004
Naltrexone treatment of combined alcohol and opioid dependence: deterioration of co-morbid major depression. Pharmacopsychiatry, 2005, Volume: 38, Issue:2 Topics: Alcoholism; Amitriptyline; Depressive Disorder, Major; Ethanol; Humans; Male; Middle Aged; Morphine; Morphine Dependence; Naltrexone; Narcotics; Severity of Illness Index; Substance Withdrawal Syndrome	2005
Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy. Pain, 2005, Volume: 115, Issue:1-2 Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Axotomy; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mice; Morphine; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Species Specificity; Treatment Outcome	2005
Amitriptyline suppresses neuroinflammation and up-regulates glutamate transporters in morphine-tolerant rats. Pain, 2006, Volume: 124, Issue:1-2 Topics: Amino Acid Transport System X-AG; Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Blotting, Western; CD11b Antigen; Cytokines; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acids; Gene Expression Regulation; Immunohistochemistry; Inflammation; Male; Microdialysis; Morphine; Morphine Dependence; Narcotics; Rats; Rats, Wistar; Spinal Cord; Time Factors	2006
Amitriptyline preserves morphine's antinociceptive effect by regulating the glutamate transporter GLAST and GLT-1 trafficking and excitatory amino acids concentration in morphine-tolerant rats. Pain, 2007, Volume: 129, Issue:3 Topics: Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Combinations; Drug Tolerance; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Injections, Spinal; Male; Morphine; Pain Measurement; Pain Threshold; Posterior Horn Cells; Protein Transport; Rats; Rats, Wistar; Signal Transduction	2007
Tramadol is more effective than morphine and amitriptyline against ischaemic pain but not thermal pain in rats. Pharmacological research, 2007, Volume: 56, Issue:1 Topics: Amitriptyline; Analgesics; Animals; Female; Hot Temperature; Hyperalgesia; Ischemia; Male; Morphine; Motor Activity; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Tramadol	2007
Transient allodynia pain models in mice for early assessment of analgesic activity. British journal of pharmacology, 2008, Volume: 153, Issue:4 Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarboxylic Acids; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Memantine; Mice; Mice, Inbred C57BL; Morphine; N-Methylaspartate; Pain; Peripheral Nervous System; Phenylephrine; Piperazines; Prostaglandin Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, N-Methyl-D-Aspartate; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Reproducibility of Results; Spinal Cord; Spinal Nerves; Time Factors	2008
Assessing free and total morphine following heroin overdose when complicated by the presence of toxic amitriptyline levels. Journal of analytical toxicology, 2007, Volume: 31, Issue:8 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Interactions; Drug Overdose; Fatal Outcome; Female; Forensic Toxicology; Heroin; Heroin Dependence; Humans; Injections, Intravenous; Morphine; Morphine Derivatives; Nortriptyline	2007
Rats with chronic post-ischemia pain exhibit an analgesic sensitivity profile similar to human patients with complex regional pain syndrome--type I. European journal of pharmacology, 2008, Mar-31, Volume: 583, Issue:1 Topics: Amitriptyline; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hindlimb; Ischemia; Male; Morphine; Pain; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Pregabalin; Rats; Rats, Long-Evans; Reflex Sympathetic Dystrophy; Regional Blood Flow; Reperfusion Injury	2008
Amitriptyline induces nuclear transcription factor-kappaB-dependent glutamate transporter upregulation in chronic morphine-infused rats. Neuroscience, 2008, May-15, Volume: 153, Issue:3 Topics: Adrenergic Uptake Inhibitors; Amino Acid Transport System X-AG; Amitriptyline; Animals; Blotting, Western; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Excitatory Amino Acids; Fluorescent Antibody Technique; Gene Expression Regulation; Image Processing, Computer-Assisted; Injections, Spinal; Male; Microdialysis; Morphine; Narcotics; NF-kappa B; Pain Threshold; Rats; Rats, Wistar; Sulfoxides; Tetrazoles; Up-Regulation	2008
Amitriptyline pretreatment preserves the antinociceptive effect of morphine in pertussis toxin-treated rats by lowering CSF excitatory amino acid concentrations and reversing the downregulation of glutamate transporters. Brain research, 2008, Sep-26, Volume: 1232 Topics: Amino Acid Transport System X-AG; Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Blotting, Western; Down-Regulation; Excitatory Amino Acids; Hot Temperature; Male; Microdialysis; Morphine; Pain; Pertussis Toxin; Rats; Rats, Wistar; Reaction Time; Spinal Cord	2008
The effect of amitriptyline, gabapentin, and carbamazepine on morphine-induced hypercarbia in rabbits. Anesthesia and analgesia, 2008, Volume: 107, Issue:4 Topics: Amines; Amitriptyline; Analgesics, Opioid; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Gabapentin; gamma-Aminobutyric Acid; Hypercapnia; Male; Morphine; Rabbits; Respiratory Insufficiency	2008
Amitriptyline suppresses neuroinflammation-dependent interleukin-10-p38 mitogen-activated protein kinase-heme oxygenase-1 signaling pathway in chronic morphine-infused rats. Anesthesiology, 2009, Volume: 110, Issue:6 Topics: Amitriptyline; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Blocking; Antidepressive Agents, Tricyclic; Drug Tolerance; Enzyme Inhibitors; Heme Oxygenase-1; Imidazoles; Interleukin-10; Male; Morphine; Myelitis; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Protoporphyrins; Pyridines; Rats; Rats, Wistar; Signal Transduction; Spinal Cord	2009
The synergistic interaction between morphine and maprotiline after intrathecal injection in rats. Anesthesia and analgesia, 2009, Volume: 109, Issue:4 Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Citalopram; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Injections, Spinal; Male; Maprotiline; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Selective Serotonin Reuptake Inhibitors; Time Factors; Yohimbine	2009
Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats. Neuroscience, 2009, Dec-15, Volume: 164, Issue:3 Topics: Amines; Amitriptyline; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Diaphragm; Disease Models, Animal; Fibromyalgia; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Morphine; Muscle, Skeletal; Neuronal Plasticity; Nociceptors; Pain Measurement; Pain Threshold; Posterior Horn Cells; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Spinal Cord; Vagotomy; Vagus Nerve; Vagus Nerve Diseases; Visceral Afferents	2009
Scopolamine-induced convulsions in fasted mice after food intake: evaluation of the sedative effect in the suppression of convulsions. Epilepsy research, 2010, Volume: 89, Issue:1 Topics: Amitriptyline; Animals; Body Weight; Chlorpromazine; Diphenhydramine; Eating; Food Deprivation; Hypnotics and Sedatives; Mice; Morphine; Scopolamine; Seizures	2010
Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin. Pain, 2010, Volume: 151, Issue:1 Topics: Amines; Amitriptyline; Analgesics; Animals; Cell Count; Cross-Over Studies; Cyclohexanecarboxylic Acids; Disease Models, Animal; Double-Blind Method; Early Growth Response Protein 1; Functional Laterality; Gabapentin; gamma-Aminobutyric Acid; Gene Expression Regulation; Hyperalgesia; Male; Morphine; Pain Threshold; Phosphopyruvate Hydratase; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries	2010
Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2011, Volume: 32, Issue:6 Topics: Amines; Amitriptyline; Analgesics; Animals; Benzoxazines; Chronic Disease; Constriction; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Ligation; Male; Morphine; Morpholines; Naphthalenes; Neuralgia; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Wistar; Time Factors	2011
Amitriptyline attenuates astrocyte activation and morphine tolerance in rats: role of the PSD-95/NR1/nNOS/PKCγ signaling pathway. Behavioural brain research, 2012, Apr-15, Volume: 229, Issue:2 Topics: Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Astrocytes; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Down-Regulation; Drug Interactions; Drug Tolerance; Injections, Spinal; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Morphine; Nitric Oxide Synthase Type I; Protein Kinase C; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; Up-Regulation	2012
The effects of serotonin/norepinephrine reuptake inhibitors and serotonin receptor agonist on morphine analgesia and tolerance in rats. The journal of physiological sciences : JPS, 2012, Volume: 62, Issue:4 Topics: Amitriptyline; Analgesia; Analgesics; Animals; Cyclohexanols; Dihydroergotamine; Drug Tolerance; Male; Morphine; Pain Measurement; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Venlafaxine Hydrochloride	2012
UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients. Pharmacogenomics, 2012, Volume: 13, Issue:8 Topics: Adult; Amitriptyline; Female; Genetic Association Studies; Glucuronosyltransferase; Haplotypes; Heroin Dependence; Humans; Linkage Disequilibrium; Male; Methadone; Middle Aged; Morphine; Polymorphism, Single Nucleotide; Pyrrolidines; Substance Withdrawal Syndrome; Taiwan	2012
New index of pain triggered by spinal activation of voltage-dependent sodium channels. Journal of anesthesia, 2013, Volume: 27, Issue:6 Topics: Amitriptyline; Animals; gamma-Aminobutyric Acid; Injections, Spinal; Lidocaine; Male; Mexiletine; Mice; Mice, Inbred ICR; Morphine; Nociceptive Pain; Pain Management; Pain Measurement; Pregabalin; Spine; Voltage-Gated Sodium Channel Agonists; Voltage-Gated Sodium Channels	2013
The Ehrlich tumor induces pain-like behavior in mice: a novel model of cancer pain for pathophysiological studies and pharmacological screening. BioMed research international, 2013, Volume: 2013 Topics: Amitriptyline; Animals; Behavior, Animal; Carcinoma, Ehrlich Tumor; Cell Proliferation; Disease Models, Animal; Drug Evaluation, Preclinical; Edema; Hyperalgesia; Indomethacin; Male; Mice; Morphine; Neoplasm Transplantation; Nociception; Pain; Subcutaneous Tissue; Temperature	2013
Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain. Pharmacological reports : PR, 2014, Volume: 66, Issue:3 Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclohexanols; Disease Models, Animal; Doxepin; Hyperalgesia; Male; Morphine; Neuralgia; Pain Measurement; Pain Threshold; Rats; Sciatic Nerve; Venlafaxine Hydrochloride	2014
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. Pharmacology, biochemistry, and behavior, 2014, Volume: 126 Topics: Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclohexanecarboxylic Acids; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Female; Gabapentin; Gait; gamma-Aminobutyric Acid; Gliosis; Hyperalgesia; Mice; Morphine; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neuralgia; Peptide Fragments; Pertussis Toxin; Quillaja Saponins	2014
Determination of pharmacological interactions of uliginosin B, a natural phloroglucinol derivative, with amitriptyline, clonidine and morphine by isobolographic analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2014, Oct-15, Volume: 21, Issue:12 Topics: Amitriptyline; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Hypericum; Male; Mice; Morphine; Pain; Phloroglucinol; Plant Components, Aerial	2014
Attenuation of morphine-induced dependence and tolerance by ceftriaxone and amitriptyline in mice. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2014, Volume: 52, Issue:4 Topics: Amitriptyline; Animals; Ceftriaxone; Drug Tolerance; Male; Mice; Morphine; Morphine Dependence	2014
Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide. Journal of pharmacological sciences, 2015, Volume: 129, Issue:4 Topics: Administration, Intravesical; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Chronic Disease; Cystitis; Disease Models, Animal; Hydrogen Peroxide; Morphine; Motor Activity; Pain; Syndrome; Time Factors	2015
The effect of amitriptyline administration on pain-related behaviors in morphine-dependent rats: Hypoalgesia or hyperalgesia? Neuroscience letters, 2018, 09-14, Volume: 683 Topics: Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Morphine; Morphine Dependence; Pain; Pain Measurement; Rats; Rats, Wistar; Treatment Outcome	2018
Irinotecan Alters the Disposition of Morphine Via Inhibition of Organic Cation Transporter 1 (OCT1) and 2 (OCT2). Pharmaceutical research, 2018, Oct-25, Volume: 35, Issue:12 Topics: Amitriptyline; Animals; Drug Interactions; Fluoxetine; HEK293 Cells; Humans; Imipramine; Irinotecan; Mice, Inbred C57BL; Morphine; Narcotics; Ondansetron; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Tissue Distribution; Verapamil	2018
High-Precision Quantitation of Biofluid Samples Using Direct Mass Spectrometry Analysis. Analytical chemistry, 2019, 06-04, Volume: 91, Issue:11 Topics: Amitriptyline; Animals; Body Fluids; Cattle; Humans; Limit of Detection; Lincomycin; Liquid Phase Microextraction; Morphine; Pharmaceutical Preparations; Spectrometry, Mass, Electrospray Ionization	2019
Analgesic adjuvants modulate morphine-induced immune effects in mice. Pharmacological reports : PR, 2019, Volume: 71, Issue:4 Topics: Adjuvants, Pharmaceutic; Amitriptyline; Analgesics, Opioid; Animals; Antigen Presentation; Cytokines; Gabapentin; Immunity, Humoral; Macrophages, Peritoneal; Male; Mice, Inbred CBA; Morphine; Phagocytosis; Venlafaxine Hydrochloride	2019