amitriptyline and mirtazapine

amitriptyline has been researched along with mirtazapine in 67 studies

Research

Studies (67)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.49)18.7374
1990's13 (19.40)18.2507
2000's23 (34.33)29.6817
2010's22 (32.84)24.3611
2020's8 (11.94)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Lombardo, F; Obach, RS; Waters, NJ1
Kenny, PW; Toulmin, A; Wood, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Gilvary, E; Glaudin, V; Panagides, J; Smith, WT1
Kuitunen, T; Mattila, M; Mattila, MJ; Vrijmoed-de Vries, M1
Bremner, JD1
Gubbels, DG; Peeters, BW; van der Heijden, R; Vanderheyden, PM1
Ekdahl, P; Høyberg, OJ; Maragakis, B; Moksnes, KM; Mullin, J; Norum, D; Ose, E; Sennef, C; Stordall, E1
Montgomery, SA1
Burrows, GD; Kremer, CM1
Kasper, S; Pols, AG; Roes, KC; Zivkov, M1
Barkin, RL; Fawcett, J2
Hoff, W; Panagides, J; Reimitz, PE; Stahl, S; Zivkov, M1
Montgomery, SA; Reimitz, PE; Zivkov, M1
Coupland, NJ; Zedkova, L1
Brown, MC; Guest, JF; Nimmerrichter, AA1
Häggström, L; Nordling, S; Norinder, A1
Foster, RH; Holm, KJ; Jarvis, B1
Borghi, J; Guest, JF1
Belinskiĭ, AV; Dorovskikh, IV; Iakovlev, VA; Zhbrykunov, VL1
Bech, P1
Sennef, C; Sitsen, JM; Timmer, CJ1
Bateman, DN; Chick, J; Good, AM; Kelly, CA; Masterton, G1
Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD1
Aderjan, R; Mattern, R; Pedal, I; Skopp, G; Wenzel, S1
Herman, ZS; Huzarska, M; Zieliński, M1
Amann, B; Hegerl, U; Juckel, G; Mergl, R; Mulert, C; Padberg, F; Pogarell, O; Sterr, A1
Silver, N2
Steinmann, C1
Akdeniz, F; Altintoprak, AE; Coskunol, H; Kitapcioglu, G; Zorlu, N1
Fisar, Z; Hroudová, J; Raboch, J1
Wichniak, A; Wierzbicka, A1
Clark, MS; Jamieson, B; Smith, PO1
Agarwal, A; Bansal, M; Conner, K1
Boessen, R; Grobbee, DE; Groenwold, RH; Knol, MJ; Roes, KC1
Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ1
Martínez-Ramírez, JA; Peters, FT; Voigt, K1
Avena-Woods, C; Hilas, O1
Blum, WF; Colla, M; Daseking, E; Deuschle, M; Gilles, M; Heuser, I; Kopf, D; Krumm, B; Lederbogen, F; Schilling, C; Weber-Hamann, B; Wudy, SA1
Clarke, G; Cryan, JF; Dinan, TG; Griffin, BT; O'Brien, FE1
Martínez-Ramírez, JA; Peters, FT; Walther, G1
Alessi-Severini, S; Bolton, J; Chateau, D; Enns, MW; Leong, C; Prior, HJ; Sareen, J1
Martínez-Ramírez, JA; Peters, FT; Strien, J; Walther, G1
Cipriani, A; Coghill, D; Cohen, D; Cuijpers, P; Del Giovane, C; Hazell, P; Hetrick, SE; Leucht, S; Liu, L; Liu, Y; Michael, KD; Pu, J; Qin, B; Ravindran, AV; Whittington, C; Xie, P; Yang, L; Zhang, Y; Zhou, X1
Berenato, F; Chan, YH; Grossman, SK; Korbutov, J; Lavery, MJ; Lee, HG; Valdes-Rodriguez, R; Yosipovitch, G1
Deckert, J; Hommers, LG; Menke, A; Samanski, L; Scherf-Clavel, M; Unterecker, S1
Feng, S; Gu, J; Jiang, X; Tang, S; Wang, L; Zheng, L1
Azevedo, A; Ferreira, S; Sanches, M; Selores, M; Velho, GC1
Bakker, MH; Hugtenburg, JG; Slottje, P; van der Horst, HE; van Straten, A1
Koziorowski, M; Mytych, J; Sołek, P; Tabęcka-Łonczyńska, A1
Ipser, JC; Phillips, NJ; Stein, DJ; Williams, T1
Butler, D; Coupland, C; Hippisley-Cox, J; Hollis, C; Jack, RH; Joseph, RM; Knaggs, RD; Morriss, R1
Benz, P; Farkas, A; Ryan, K; Theobald, J; Zosel, A1
Hatano, M; Ikuta, T; Iwata, N; Kishi, T; Matsuda, Y; Okuya, M; Sakuma, K1
Alto, M; Giusto, A; Greene, MC; Johnson, RM; Kane, J; Lovero, K; McClendon, J; Nicholson, T; Stockton, M; Tol, WA; Wainberg, ML1

Reviews

19 review(s) available for amitriptyline and mirtazapine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Safety of mirtazapine: a review.
    International clinical psychopharmacology, 1995, Volume: 10 Suppl 4

    Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Overdose; Female; Humans; Male; Mianserin; Middle Aged; Mirtazapine; Randomized Controlled Trials as Topic; Risk Factors; Treatment Outcome

1995
Mirtazapine: clinical advantages in the treatment of depression.
    Journal of clinical psychopharmacology, 1997, Volume: 17 Suppl 1

    Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Clomipramine; Depressive Disorder; Feeding and Eating Disorders; Humans; Mianserin; Mirtazapine; Sleep Stages; Weight Gain

1997
Pharmacological treatment of severely depressed patients: a meta-analysis comparing efficacy of mirtazapine and amitriptyline.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1997, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Female; Humans; Male; Mianserin; Middle Aged; Mirtazapine

1997
Efficacy issues with antidepressants.
    The Journal of clinical psychiatry, 1997, Volume: 58 Suppl 6

    Topics: Absenteeism; Age Factors; Amitriptyline; Antidepressive Agents; Combined Modality Therapy; Controlled Clinical Trials as Topic; Depressive Disorder; Follow-Up Studies; Humans; Imipramine; Mianserin; Mirtazapine; Outcome Assessment, Health Care; Placebos; Psychiatric Status Rating Scales; Psychotherapy; Severity of Illness Index; Treatment Outcome; Work

1997
Meta-analysis of randomized, double-blind, placebo-controlled, efficacy and safety studies of mirtazapine versus amitriptyline in major depression.
    Acta psychiatrica Scandinavica. Supplementum, 1997, Volume: 391

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Mianserin; Middle Aged; Mirtazapine; Placebos; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome

1997
A meta-analysis of eight randomized, double-blind, controlled clinical trials of mirtazapine for the treatment of patients with major depression and symptoms of anxiety.
    The Journal of clinical psychiatry, 1998, Volume: 59, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Mianserin; Middle Aged; Mirtazapine; Placebos; Psychomotor Agitation; Randomized Controlled Trials as Topic; Somatoform Disorders

1998
Cost-effectiveness of mirtazapine compared to amitriptyline and fluoxetine in the treatment of moderate and severe depression in austria.
    European psychiatry : the journal of the Association of European Psychiatrists, 1999, Volume: 14, Issue:4

    Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Austria; Cost-Benefit Analysis; Depressive Disorder; Double-Blind Method; Drug Hypersensitivity; Fluoxetine; Humans; Mianserin; Mirtazapine; Retrospective Studies; Severity of Illness Index

1999
[Treatment of depression and cost efficiency. The cost of a tablet is a poor indicator seen from a socioeconomic perspective].
    Lakartidningen, 2000, Apr-05, Volume: 97, Issue:14

    Topics: Adrenergic alpha-Agonists; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cost of Illness; Cost-Benefit Analysis; Depression; Drug Costs; Fluoxetine; Histamine H1 Antagonists; Humans; Mianserin; Mirtazapine; Models, Economic; Socioeconomic Factors; Sweden

2000
Mirtazapine. A pharmacoeconomic review of its use in depression.
    PharmacoEconomics, 2000, Volume: 17, Issue:5

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Humans; Mianserin; Mirtazapine; Quality of Life; Selective Serotonin Reuptake Inhibitors

2000
Meta-analysis of placebo-controlled trials with mirtazapine using the core items of the Hamilton Depression Scale as evidence of a pure antidepressive effect in the short-term treatment of major depression.
    The international journal of neuropsychopharmacology, 2001, Volume: 4, Issue:4

    Topics: Adult; Affect; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Dose-Response Relationship, Drug; Humans; Mianserin; Mirtazapine; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Treatment Outcome

2001
Headache (chronic tension-type).
    Clinical evidence, 2005, Issue:14

    Topics: Acupuncture Therapy; Amitriptyline; Antidepressive Agents, Tricyclic; Cognitive Behavioral Therapy; Humans; Mianserin; Mirtazapine; Tension-Type Headache

2005
[Suspected depression].
    MMW Fortschritte der Medizin, 2006, Aug-17, Volume: 148, Issue:33-34

    Topics: Adult; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Depression; Diagnosis, Differential; Female; Humans; Male; Mianserin; Mirtazapine; Neurology; Psychiatry; Referral and Consultation; Suicide; Time Factors

2006
Headache (chronic tension-type).
    American family physician, 2007, Jul-01, Volume: 76, Issue:1

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents; Biofeedback, Psychology; Chronic Disease; Cognitive Behavioral Therapy; Humans; Incidence; Massage; Mianserin; Mirtazapine; Prevalence; Prognosis; Randomized Controlled Trials as Topic; Relaxation Therapy; Risk Factors; Tension-Type Headache

2007
[The effects of antidepressants on sleep in depressed patients with particular reference to trazodone in comparison to agomelatine, amitriptyline, doxepin, mianserine and mirtazapine].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2011, Volume: 31, Issue:181

    Topics: Amitriptyline; Antidepressive Agents; Depression; Doxepin; Humans; Mianserin; Mirtazapine; Sleep; Sleep Initiation and Maintenance Disorders; Sleep, REM; Trazodone

2011
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
    Lancet (London, England), 2016, Aug-27, Volume: 388, Issue:10047

    Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Confounding Factors, Epidemiologic; Depressive Disorder, Major; Desipramine; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Evidence-Based Medicine; Fluoxetine; Humans; Imipramine; Mianserin; Mirtazapine; Nortriptyline; Paroxetine; Piperazines; Randomized Controlled Trials as Topic; Research Design; Sertraline; Treatment Outcome; Triazoles; Venlafaxine Hydrochloride

2016
Pharmacotherapy for post traumatic stress disorder (PTSD).
    The Cochrane database of systematic reviews, 2022, 03-02, Volume: 3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Humans; Middle Aged; Mirtazapine; Paroxetine; Selective Serotonin Reuptake Inhibitors; Stress Disorders, Post-Traumatic; Young Adult

2022
Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase: a systematic review and network meta-analysis.
    Molecular psychiatry, 2023, Volume: 28, Issue:1

    Topics: Adult; Amitriptyline; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Desvenlafaxine Succinate; Duloxetine Hydrochloride; Female; Fluoxetine; Fluvoxamine; Humans; Mirtazapine; Network Meta-Analysis; Paroxetine; Randomized Controlled Trials as Topic; Reboxetine; Sertraline; Venlafaxine Hydrochloride; Vortioxetine

2023
Psychosocial and pharmacologic interventions to reduce harmful alcohol use in low- and middle-income countries.
    The Cochrane database of systematic reviews, 2023, 05-09, Volume: 5

    Topics: Acamprosate; Alcoholism; Amitriptyline; Developing Countries; Disulfiram; Humans; Male; Mirtazapine; Naltrexone; Ondansetron; Topiramate

2023

Trials

12 trial(s) available for amitriptyline and mirtazapine

ArticleYear
Mirtazapine vs. amitriptyline vs. placebo in the treatment of major depressive disorder.
    Psychopharmacology bulletin, 1990, Volume: 26, Issue:2

    Topics: Adult; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Mianserin; Mirtazapine; Psychiatric Status Rating Scales

1990
Actions and interactions of psychotropic drugs on human performance and mood: single doses of ORG 3770, amitriptyline, and diazepam.
    Pharmacology & toxicology, 1989, Volume: 65, Issue:2

    Topics: Adult; Affect; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Cognition; Diazepam; Drug Interactions; Female; Humans; Male; Mianserin; Mirtazapine; Placebos; Psychomotor Performance; Random Allocation

1989
A double-blind comparison of Org 3770, amitriptyline, and placebo in major depression.
    The Journal of clinical psychiatry, 1995, Volume: 56, Issue:11

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Constipation; Depressive Disorder; Double-Blind Method; Drug Administration Schedule; Humans; Mianserin; Mirtazapine; Personality Inventory; Placebos; Psychiatric Status Rating Scales; Severity of Illness Index; Sleep; Treatment Outcome; Xerostomia

1995
A double-blind multicentre comparison of mirtazapine and amitriptyline in elderly depressed patients.
    Acta psychiatrica Scandinavica, 1996, Volume: 93, Issue:3

    Topics: Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Mianserin; Middle Aged; Mirtazapine; Personality Inventory; Treatment Outcome

1996
Pharmacological treatment of severely depressed patients: a meta-analysis comparing efficacy of mirtazapine and amitriptyline.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1997, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Female; Humans; Male; Mianserin; Middle Aged; Mirtazapine

1997
Mirtazapine versus amitriptyline in the long-term treatment of depression: a double-blind placebo-controlled study.
    International clinical psychopharmacology, 1998, Volume: 13, Issue:2

    Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Mianserin; Middle Aged; Mirtazapine; Psychiatric Status Rating Scales; Survival Analysis

1998
Cost-effectiveness of mirtazapine compared to amitriptyline and fluoxetine in the treatment of moderate and severe depression in austria.
    European psychiatry : the journal of the Association of European Psychiatrists, 1999, Volume: 14, Issue:4

    Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Austria; Cost-Benefit Analysis; Depressive Disorder; Double-Blind Method; Drug Hypersensitivity; Fluoxetine; Humans; Mianserin; Mirtazapine; Retrospective Studies; Severity of Illness Index

1999
[Comparative efficacy of remeron (mirtazapine) and amitriptyline in treatment of patients with depression of moderate intensity].
    Voenno-meditsinskii zhurnal, 2000, Volume: 321, Issue:10

    Topics: Adrenergic alpha-Antagonists; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Histamine H1 Antagonists; Humans; Male; Mianserin; Middle Aged; Mirtazapine

2000
Mirtazapine in combination with amitriptyline: a drug-drug interaction study in healthy subjects.
    Human psychopharmacology, 2003, Volume: 18, Issue:2

    Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Attention; Cognition; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Mental Processes; Mianserin; Mirtazapine; Psychomotor Performance; Single-Blind Method

2003
Effectiveness and tolerability of mirtazapine and amitriptyline in alcoholic patients with co-morbid depressive disorder: a randomized, double-blind study.
    Human psychopharmacology, 2008, Volume: 23, Issue:4

    Topics: Adult; Alcoholism; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Double-Blind Method; Educational Status; Female; Humans; Male; Mianserin; Middle Aged; Mirtazapine; Surveys and Questionnaires

2008
Leptin plasma concentrations increase during antidepressant treatment with amitriptyline and mirtazapine, but not paroxetine and venlafaxine: leptin resistance mediated by antihistaminergic activity?
    Journal of clinical psychopharmacology, 2013, Volume: 33, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Analysis of Variance; Antidepressive Agents; Biomarkers; Body Mass Index; Cyclohexanols; Depression; Female; Humans; Leptin; Male; Mianserin; Middle Aged; Mirtazapine; Paroxetine; Time Factors; Treatment Outcome; Up-Regulation; Venlafaxine Hydrochloride; Weight Gain; Young Adult

2013
Effectiveness of low-dose amitriptyline and mirtazapine for insomnia disorder: study protocol of a randomised, double-blind, placebo-controlled trial in general practice (the DREAMING study).
    BMJ open, 2021, 09-02, Volume: 11, Issue:9

    Topics: Adult; Amitriptyline; Antidepressive Agents; Double-Blind Method; General Practice; Humans; Mirtazapine; Randomized Controlled Trials as Topic; Sleep Initiation and Maintenance Disorders; Treatment Outcome

2021

Other Studies

38 other study(ies) available for amitriptyline and mirtazapine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Toward prediction of alkane/water partition coefficients.
    Journal of medicinal chemistry, 2008, Jul-10, Volume: 51, Issue:13

    Topics: Alkanes; Central Nervous System; Molecular Structure; Static Electricity; Surface Properties; Water

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Effects of chronic antidepressant treatment on the hypothalamic-pituitary-adrenal axis of Wistar rats.
    Annals of the New York Academy of Sciences, 1994, Nov-30, Volume: 746

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Body Weight; Corticosterone; Hippocampus; Hypothalamo-Hypophyseal System; Imipramine; Kinetics; Male; Mianserin; Mirtazapine; Pituitary-Adrenal System; Rats; Rats, Wistar; Receptors, Glucocorticoid; Reference Values

1994
Hypertension during coprescription of mirtazapine and low-dose amitriptyline.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1998, Volume: 43, Issue:8

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Therapy, Combination; Humans; Hypertension; Male; Mianserin; Middle Aged; Mirtazapine

1998
Economic impact of using mirtazapine compared to amitriptyline and fluoxetine in the treatment of moderate and severe depression in the UK.
    European psychiatry : the journal of the Association of European Psychiatrists, 2000, Volume: 15, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Cost-Benefit Analysis; Depression; Fluoxetine; Humans; Mianserin; Middle Aged; Mirtazapine; Severity of Illness Index; United Kingdom

2000
Are selective serotonin re-uptake inhibitors associated with an increased risk of self-harm by antidepressant overdose?
    European journal of clinical pharmacology, 2004, Volume: 60, Issue:3

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Doxepin; Drug Overdose; Drug Prescriptions; Emergency Service, Hospital; Female; Fluoxetine; Humans; Imipramine; Information Services; Male; Mianserin; Mirtazapine; Paroxetine; Patient Admission; Patient Readmission; Poison Control Centers; Retrospective Studies; Risk Assessment; Scotland; Selective Serotonin Reuptake Inhibitors; Self-Injurious Behavior; Sertraline; Trazodone; Venlafaxine Hydrochloride

2004
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain.
    Neuropharmacology, 2005, Volume: 48, Issue:2

    Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopram; Disease Models, Animal; Duloxetine Hydrochloride; Male; Mianserin; Mirtazapine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes

2005
Tissue distribution of mirtazapine and desmethylmirtazapine in a case of mirtazapine poisoning.
    Forensic science international, 2006, Jan-27, Volume: 156, Issue:2-3

    Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Bile; Brain Chemistry; Forensic Pathology; Gas Chromatography-Mass Spectrometry; Gastrointestinal Contents; Humans; Kidney; Liver; Lung; Male; Mianserin; Mirtazapine; Muscle, Skeletal; Nortriptyline; Sertraline; Suicide; Tissue Distribution

2006
Repeated treatment with antidepressants enhances dopamine D1 receptor gene expression in the rat brain.
    European journal of pharmacology, 2006, Feb-27, Volume: 532, Issue:3

    Topics: Amitriptyline; Animals; Antidepressive Agents; Corpus Striatum; Gene Expression Regulation; Male; Mianserin; Mirtazapine; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Dopamine D1; RNA, Messenger; Sertraline; Time Factors; Transcriptional Activation

2006
Electroencephalographic abnormalities associated with antidepressant treatment: a comparison of mirtazapine, venlafaxine, citalopram, reboxetine, and amitriptyline.
    The Journal of clinical psychiatry, 2006, Volume: 67, Issue:2

    Topics: Adult; Amitriptyline; Antidepressive Agents; Cerebral Cortex; Citalopram; Cyclohexanols; Electroencephalography; Epilepsy; Female; Humans; Male; Mental Disorders; Mianserin; Middle Aged; Mirtazapine; Morpholines; Reboxetine; Venlafaxine Hydrochloride

2006
Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.
    Neuro endocrinology letters, 2010, Volume: 31, Issue:5

    Topics: Affect; Amitriptyline; Animals; Antidepressive Agents; Antimanic Agents; Benzodiazepines; Cerebral Cortex; Citalopram; Clorgyline; Cocaine; Cyclohexanols; Desipramine; Fluoxetine; Imipramine; In Vitro Techniques; Iproniazid; Lithium; Mianserin; Mirtazapine; Mitochondria; Moclobemide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Morpholines; Olanzapine; Pargyline; Reboxetine; Swine; Thiazepines; Valproic Acid; Venlafaxine Hydrochloride

2010
FPIN's clinical inquiries: Antidepressants for the treatment of insomnia in patients with depression.
    American family physician, 2011, Nov-01, Volume: 84, Issue:9

    Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Dose-Response Relationship, Drug; Doxepin; Evidence-Based Medicine; Humans; Mianserin; Mirtazapine; Practice Guidelines as Topic; Sleep Initiation and Maintenance Disorders; Trazodone; Trimipramine

2011
Coma blisters with hypoxemic respiratory failure.
    Dermatology online journal, 2012, Mar-15, Volume: 18, Issue:3

    Topics: Amitriptyline; Anti-Bacterial Agents; Blister; Coma; Diazepam; Drug Therapy, Combination; Female; Humans; Mianserin; Mirtazapine; Oxycodone; Oxygen; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pneumonia; Pneumonia, Aspiration; Quadriplegia; Respiratory Insufficiency; Treatment Outcome; Young Adult

2012
Classifying responders and non-responders; does it help when there is evidence of differentially responding patient groups?
    Journal of psychiatric research, 2012, Volume: 46, Issue:9

    Topics: Amitriptyline; Antidepressive Agents; Chi-Square Distribution; Clinical Trials as Topic; Computer Simulation; Depressive Disorder; Female; Humans; Male; Mianserin; Mirtazapine; Models, Statistical; Psychiatric Status Rating Scales; Sample Size; Treatment Outcome

2012
Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats.
    European journal of pharmacology, 2012, Sep-15, Volume: 691, Issue:1-3

    Topics: Amitriptyline; Animals; Anti-Ulcer Agents; Antidepressive Agents; Disease Models, Animal; Duloxetine Hydrochloride; Fluoxetine; Immersion; Indomethacin; Male; Mianserin; Mirtazapine; Rats; Rats, Sprague-Dawley; Reserpine; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Thiophenes; Water

2012
Studies on the metabolism of five model drugs by fungi colonizing cadavers using LC-ESI-MS/MS and GC-MS analysis.
    Analytical and bioanalytical chemistry, 2012, Volume: 404, Issue:5

    Topics: Absidia; Amitriptyline; Aspergillus; Biotransformation; Cadaver; Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Gliocladium; Hydroxylation; Methylation; Metoprolol; Mianserin; Mirtazapine; Mortierella; Oxidation-Reduction; Pharmaceutical Preparations; Promethazine; Pyridines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Zolpidem

2012
Antidepressant use in underweight older adults.
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2012, Volume: 27, Issue:12

    Topics: Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Appetite; Body Mass Index; Body Weight; Depressive Disorder, Major; Duloxetine Hydrochloride; Hospitals, University; Humans; Inservice Training; Mianserin; Mirtazapine; Practice Patterns, Physicians'; Retrospective Studies; Thinness; Thiophenes

2012
Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:10

    Topics: Amitriptyline; Animals; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Capillary Permeability; Dogs; Duloxetine Hydrochloride; Fluoxetine; Humans; Imipramine; Madin Darby Canine Kidney Cells; Mianserin; Mirtazapine; Thiophenes; Transfection

2013
Studies on drug metabolism by fungi colonizing decomposing human cadavers. Part II: biotransformation of five model drugs by fungi isolated from post-mortem material.
    Drug testing and analysis, 2015, Volume: 7, Issue:4

    Topics: Amitriptyline; Biotransformation; Cadaver; Fungi; Humans; Metoprolol; Mianserin; Mirtazapine; Promethazine; Pyridines; Zolpidem

2015
New antidepressant use in older adults: a Canadian population-based study (1997-2013).
    Aging & mental health, 2017, Volume: 21, Issue:7

    Topics: Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cross-Sectional Studies; Drug Prescriptions; Drug Utilization; Female; Humans; Male; Manitoba; Mianserin; Middle Aged; Mirtazapine; Retrospective Studies; Trazodone; Venlafaxine Hydrochloride

2017
Search for fungi-specific metabolites of four model drugs in postmortem blood as potential indicators of postmortem fungal metabolism.
    Forensic science international, 2016, Volume: 262

    Topics: Aged; Amitriptyline; Biotransformation; Cardiovascular Agents; Central Nervous System Agents; Chromatography, Liquid; Female; Fungi; Humans; Male; Metoprolol; Mianserin; Middle Aged; Mirtazapine; Postmortem Changes; Pyridines; Tandem Mass Spectrometry; Zolpidem

2016
Topical ketamine-amitriptyline-lidocaine for chronic pruritus: A retrospective study assessing efficacy and tolerability.
    Journal of the American Academy of Dermatology, 2017, Volume: 76, Issue:4

    Topics: Aged; Amines; Amitriptyline; Analgesics; Chronic Disease; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Ketamine; Lidocaine; Male; Mianserin; Mirtazapine; Pain Measurement; Pruritus; Retrospective Studies

2017
Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2.
    International clinical psychopharmacology, 2019, Volume: 34, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Clozapine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Desvenlafaxine Succinate; Doxepin; Drug Monitoring; Female; Glucuronosyltransferase; Humans; Male; Middle Aged; Mirtazapine; Nortriptyline; Paliperidone Palmitate; Quetiapine Fumarate; Retrospective Studies; Risperidone; Smoking; Venlafaxine Hydrochloride

2019
In-vitro and in situ assessment of the efflux of five antidepressants by breast cancer resistance protein.
    The Journal of pharmacy and pharmacology, 2019, Volume: 71, Issue:7

    Topics: Amitriptyline; Animals; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Transport; Blood-Brain Barrier; Brain; Cell Line, Tumor; Duloxetine Hydrochloride; Fluoxetine; Humans; Mirtazapine; Neoplasm Proteins; Rats; Rats, Sprague-Dawley; Sertraline

2019
Epidermolysis Bullosa Pruriginosa successfully treated with concomitant topical and systemic agents.
    The Australasian journal of dermatology, 2020, Volume: 61, Issue:4

    Topics: Administration, Topical; Amitriptyline; Analgesics; Drug Therapy, Combination; Epidermolysis Bullosa Dystrophica; Histamine H1 Antagonists; Humans; Ketamine; Male; Middle Aged; Mirtazapine; Pruritus

2020
Molecular Consequences of Depression Treatment: A Potential In Vitro Mechanism for Antidepressants-Induced Reprotoxic Side Effects.
    International journal of molecular sciences, 2021, Nov-01, Volume: 22, Issue:21

    Topics: Amitriptyline; Animals; Antidepressive Agents; Antipsychotic Agents; Cell Line; Escitalopram; Fluoxetine; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation; Imipramine; Male; Mice; Micronuclei, Chromosome-Defective; Mirtazapine; Models, Biological; Olanzapine; Organ Specificity; Reboxetine; Reproduction; Signal Transduction; Spermatogenesis; Telomeric Repeat Binding Protein 1; Telomeric Repeat Binding Protein 2; Time Factors; Venlafaxine Hydrochloride

2021
Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records.
    Evidence-based mental health, 2022, Volume: 25, Issue:4

    Topics: Amitriptyline; Antidepressive Agents; Cohort Studies; Depression; Electronic Health Records; Humans; Mirtazapine; Selective Serotonin Reuptake Inhibitors; Suicide; United Kingdom; Venlafaxine Hydrochloride

2022
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes".
    Cardiovascular toxicology, 2022, Volume: 22, Issue:9

    Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long QT Syndrome; Methadone; Mirtazapine; Poison Control Centers; Retrospective Studies; Risk Factors; Tachycardia, Ventricular; Torsades de Pointes; Trazodone; Ventricular Fibrillation

2022